keyword
MENU ▼
Read by QxMD icon Read
search

food allergy colitis

keyword
https://www.readbyqxmd.com/read/30531969/pdl2-cd11b-dermal-dendritic-cells-capture-topical-antigen-through-hair-follicles-to-prime-lap-tregs
#1
Leticia Tordesillas, Daniel Lozano-Ojalvo, David Dunkin, Lucie Mondoulet, Judith Agudo, Miriam Merad, Hugh A Sampson, M Cecilia Berin
The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Topical antigen is acquired by Langerhans cells (LC) and CD11b+ cDC2s but not cDC1s, and both  LCs and CD11b+ cDC2s reaching the lymph node can prime T cells and expand LAP+ Tregs. However, LCs are neither required nor sufficient for T cell priming, and have no role in tolerance induction...
December 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/30357921/what-can-primary-immunodeficiencies-teach-us-about-th9-cell-differentiation-function
#2
Lisa Worley, Stuart G Tangye, Cindy S Ma
Interleukin-9 (IL-9) producing CD4+ Th9 cells are a unique subset of effector cells involved in both health and disease. Th9 cells have been associated with protective immunity during parasitic infections with helminths, protozoans and extracellular pathogens, but implicated in disease states such as allergic asthma, atopic dermatitis, food allergy and autoimmune conditions including multiple sclerosis and ulcerative colitis. Here, we review the cytokine signalling pathways and downstream transcription factors required for IL-9 expression and how human primary immunodeficiencies due to monogenic mutations can help elucidate the complex requirements for human Th9 cell differentiation...
October 25, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/30066901/triticum-aestivum-sprout-extract-attenuates-2-4%C3%A2-dinitrochlorobenzene%C3%A2-induced-atopic-dermatitis%C3%A2-like-skin-lesions-in-mice-and-the-expression-of-chemokines-in-human-keratinocytes
#3
Ji-Hyun Lee, Hyeon-Hui Ki, Dae-Ki Kim, Young-Mi Lee
Atopic dermatitis (AD) is a common chronic, recurring, inflammatory skin disease. A number of researchers have been seeking safe AD therapies for a long time. Triticum aestivum sprouts (TAEE), known as wheatgrass, are one of the most widely used health foods worldwide. They show numerous beneficial effects, including anticancer, anti‑inflammatory, anti‑oxidant, anti‑obesity, anti‑colitis and anti‑allergy effects; however, their effect on AD is unknown. In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells)...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29922282/cord-blood-cd8-t-cells-have-a-natural-propensity-to-express-il-4-in-a-fatty-acid-metabolism-and-caspase-activation-dependent-manner
#4
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC 2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29780153/food-specific-iggs-are-highly-increased-in-the-sera-of-patients-with-inflammatory-bowel-disease-and-are-clinically-relevant-to-the-pathogenesis
#5
Nanping Xiao, Fenghua Liu, Guangxi Zhou, Mingming Sun, Fengfu Ai, Zhanju Liu
Objective Dietary antigens are common luminal antigens in the gastrointestinal tract and have been considered to contribute to the pathogenesis of inflammatory bowel disease (IBD). We analyzed the levels of food-specific IgGs against a variety of dietary antigens, explored the clinical relevance of food allergy to the pathogenesis of IBD, and investigated whether or not infliximab (IFX) treatment could regulate the immune responses induced by dietary antigens. Methods A total of 301 IBD patients, including 201 patients with Crohn's disease (CD) and 100 patients with ulcerative colitis (UC), were recruited, and their serum food-specific IgGs against 14 food antigens were detected by a semi-quantitative enzyme linked immunosorbent assay (ELISA)...
October 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29755892/regional-control-of-regulatory-immune-cells-in-the-intestine
#6
Tina L Morhardt, Atsushi Hayashi, John Y Kao, Nobuhiko Kamada
Purpose of review: The intestine contains the largest compartment of immune regulatory cells which include T regulatory cells and IL-10 producing macrophages. These cell populations serve to restrain unnecessary immune responses of the intestine, which may lead to the pathogenesis of Crohn's disease or food allergy. Recent findings: This review discusses the recent findings pertaining to the functional regulation of these cells which may provide insight into novel therapies...
March 2018: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29533199/eosinophilic-gastroenteritis-and-other-eosinophilic-gut-diseases-distal-to-the-oesophagus
#7
REVIEW
Marjorie M Walker, Michael Potter, Nicholas J Talley
Under normal physiological conditions, eosinophils are present throughout the gastrointestinal tract distal to the squamous oesophagus. Increases in their numbers signify primary and secondary eosinophilic conditions. The rare primary eosinophilic diseases eosinophilic gastroenteritis and eosinophilic colitis affect fewer than ten in 100 000 people, and are characterised by numerous mucosal eosinophils, distributed in sheets and sometimes extending from the mucosa into the submucosa. Pathogenesis of these diseases is poorly understood, but food allergies and intestinal dysbiosis have been implicated...
April 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29247205/prostaglandin-d-2-metabolite-in-urine-is-an-index-of-food-allergy
#8
Shingo Maeda, Tatsuro Nakamura, Hiroaki Harada, Yuri Tachibana, Kosuke Aritake, Tatsuo Shimosawa, Yutaka Yatomi, Takahisa Murata
Food allergy is immediate hypersensitive reactions to ingested foods. Since early diagnosis is effective for disease control, development of an objective diagnostic index is required. Using mediator-lipidomics, we found that levels of the urinary prostaglandin D2 (PGD2 ) metabolite, tetranor-PGDM, reflected the severity of the allergic symptoms and intestinal mast cell hyperplasia in mice. Repeated oral challenges with ovalbumin promoted allergic symptoms in sensitized mice. Particularly, the allergic mice presented with increased numbers of intestinal mast cells, which strongly expressed hematopoietic PGD synthase (H-PGDS)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141406/rutinosylated-ferulic-acid-attenuates-food-allergic-response-and-colitis-by-upregulating-regulatory-t-cells-in-mouse-models
#9
Shigeru Katayama, Fumiaki Ohno, Takakazu Mitani, Hiroshi Akiyama, Soichiro Nakamura
The purpose of this study was to screen phytochemicals capable of inducing immune tolerance via enhanced transforming growth factor-β1 (TGF-β1) secretion and investigate their effects in a mouse model of food allergy and colitis. In a screening test using THP-1-derived dendritic cells, a significant increase in TGF-β1 levels was observed upon treatment with ferulic acid and its glycosides, among which ferulic acid rutinoside (FAR) induced the highest level of TGF-β1 secretion. Oral administration of FAR suppressed serum levels of immunoglobulin E and histamine in ovalbumin-sensitized mice and triggered the differentiation of regulatory T (Treg) cells...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29058101/dock8-deficiency-presenting-as-an-ipex-like-disorder
#10
Fayhan J Alroqi, Louis-Marie Charbonnier, Sevgi Keles, Fatima Ghandour, Pierre Mouawad, Rami Sabouneh, Reem Mohammed, Abduarahman Almutairi, Janet Chou, Michel J Massaad, Raif S Geha, Zeina Baz, Talal A Chatila
PURPOSE: The dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive-combined immunodeficiency whose clinical spectra include recurrent infections, autoimmunity, malignancies, elevated serum IgE, eczema, and food allergies. Here, we report on patients with loss of function DOCK8 mutations with profound immune dysregulation suggestive of an immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)-like disorder. METHODS: Immunophenotyping of lymphocyte subpopulations and analysis of DOCK8 protein expression were evaluated by flow cytometry...
November 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28626380/clinical-and-pathologic-remission-of-pediatric-ulcerative-colitis-with-serum-derived-bovine-immunoglobulin-added-to-the-standard-treatment-regimen
#11
Rachelle A Soriano, Asuncion G Ramos-Soriano
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is particularly troublesome for pediatric patients, as current therapeutic options consist of biologic agents and steroids which alter the immune response and have the harmful side effect of leaving the patient more susceptible to opportunistic infections and eventual surgery. Another option for therapy exists in the form of serum-derived bovine immunoglobulin/protein isolate (SBI), the key ingredient in a medical food, EnteraGam®. The FDA has reviewed the safety of SBI and issued a no challenge letter to the generally recognized as safe (GRAS) findings for this medical food...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28477201/isolation-and-purification-of-th9-cells-for-the-study-of-inflammatory-diseases-in-research-and-clinical-settings
#12
Patricia Keating, James X Hartmann
Th9 cells are associated with atopic and inflammatory diseases, and their increased levels and function correlate with the severity of symptoms in various inflammatory disorders including asthma, food allergy, atopic dermatitis, ulcerative colitis, and psoriatic arthritis. Thus, clinical trials are warranted to evaluate the role of Th9 cells in allergic diseases with the goal of controlling these ailments.Circulating T cells (naïve or memory CD4+ T cells) purified from human blood and expanded using anti-CD3 and anti-CD28 antibodies can be treated with appropriate cytokines in order to polarize them to the Th9 phenotype as evidenced by their production of IL-9...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28370715/l-fermentum-cect-5716-prevents-stress-induced-intestinal-barrier-dysfunction-in-newborn-rats
#13
T Vanhaecke, P Aubert, P-A Grohard, T Durand, P Hulin, P Paul-Gilloteaux, A Fournier, F Docagne, A Ligneul, C Fressange-Mazda, P Naveilhan, H Boudin, P Le Ruyet, M Neunlist
BACKGROUND: Intestinal epithelial barrier (IEB) dysfunction plays a critical role in various intestinal disorders affecting infants and children, including the development of food allergies and colitis. Recent studies highlighted the role of probiotics in regulating IEB functions and behavior in adults, but their effects in the newborn remain largely unknown. We therefore characterized in rat pups, the impact of Lactobacillus fermentum CECT 5716 (L. fermentum) on stress-induced IEB dysfunction, systemic immune response and exploratory behavior...
August 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28337229/allergic-enteritis-in-children
#14
REVIEW
Mieczysława Czerwionka-Szaflarska, Ewa Łoś-Rycharska, Julia Gawryjołek
The gastrointestinal form of food allergy is very common in children. The most frequently observed types are allergic proctitis and proctocolitis. In most cases the symptoms subside within the first 2 months of life. The babies seem healthy, and the only abnormality is a small amount of blood in stool. Symptoms can also include small intestine inflammation and colitis. Patients may present with irritability, abdominal pain, flatulence, colic, postprandial vomiting, chronic diarrhoea, and hindered physical development...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28261032/eosinophilic-colitis-in-children
#15
Urszula Grzybowska-Chlebowczyk, Sabina Horowska-Ziaja, Maciej Kajor, Sabina Więcek, Wojciech Chlebowczyk, Halina Woś
INTRODUCTION: Eosinophilic colitis, which is a rare form of eosinophilic gastrointestinal diseases, occurs as primary and secondary allergic eosinophilic colitis of the gastrointestinal tract infection, inflammatory bowel disease, celiac disease, and vasculitis. The diagnosis is based on a significant amount of eosinophils in the inflammatory infiltrate of the colon wall. AIM: To analyze the clinical picture taking into account comorbidities and endoscopic picture in children with eosinophilic colitis...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28226319/oral-and-sublingual-immunotherapy-potential-causes-for-eosinophilic-gastrointestinal-disorders
#16
REVIEW
Delara Babaie, Mehrnaz Mesdaghi, Makoto Nishino, Mahboubeh Mansouri, Motohiro Ebisawa
Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27733383/intestinal-inflammation-without-weight-loss-decreases-bone-density-and-growth
#17
Regina Irwin, Sandi Raehtz, Narayanan Parameswaran, Laura R McCabe
Increasing evidence indicates a strong link between intestinal health and bone health. For example, inflammatory bowel disease can cause systemic inflammation, weight loss, and extra-intestinal manifestations, such as decreased bone growth and density. However, the effects of moderate intestinal inflammation without weight loss on bone health have never been directly examined; yet this condition is relevant not only to IBD but to conditions of increased intestinal permeability and inflammation, as seen with ingestion of high-fat diets, intestinal dysbiosis, irritable bowel syndrome, metabolic syndrome, and food allergies...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27604348/induction-of-colitis-in-mice-with-food-allergen-specific-immune-response
#18
Lin-Jing Li, Lu Zeng, Xiao-Xi Li, Li-Hua Mo, Xiao-Rui Geng, Peng-Yuan Zheng, Zhi-Gang Liu, Bai-Sui Feng, Ping-Chang Yang
The pathogenesis of intestinal chronic inflammation is unclear. Food allergy plays an important role in the induction of intestinal inflammation. This study aims to test a hypothesis that food allergy initiates colitis. In this study, BALB/c mice were sensitized to a common food allergen, ovalbumin (OVA) with cholera toxin (CT) as an adjuvant. The colon epithelial barrier function was assessed with Ussing chamber technique. Expression of T cell immunoglobulin mucin domain molecule-4 (TIM4) in dendritic cells was evaluated by flow cytometry, RT-PCR and Western blotting...
September 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27499766/specific-immunotherapy-ameliorates-ulcerative-colitis
#19
Min Cai, Lu Zeng, Lin-Jing Li, Li-Hua Mo, Rui-Di Xie, Bai-Sui Feng, Peng-Yuan Zheng, Zhi-Gang Liu, Zhan-Ju Liu, Ping-Chang Yang
BACKGROUND: Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients. METHODS: Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum specific IgE. The patients were treated with specific immunotherapy (SIT) and Clostridium butyricum (CB) capsules...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27432247/anaerobes-as-sources-of-bioactive-compounds-and-health-promoting-tools
#20
REVIEW
Gashaw Mamo
Aerobic microorganisms have been sources of medicinal agents for several decades and an impressive variety of drugs have been isolated from their cultures, studied and formulated to treat or prevent diseases. On the other hand, anaerobes, which are believed to be the oldest life forms on earth and evolved remarkably diverse physiological functions, have largely been neglected as sources of bioactive compounds. However, results obtained from the limited research done so far show that anaerobes are capable of producing a range of interesting bioactive compounds that can promote human health...
2016: Advances in Biochemical Engineering/biotechnology
keyword
keyword
171736
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"