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Liming Liang

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https://www.readbyqxmd.com/read/30487518/interethnic-analyses-of-blood-pressure-loci-in-populations-of-east-asian-and-european-descent
#1
Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L Nierenberg, Ya Xing Wang, Jing He, Derrick A Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R Lee, Linda S Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F Reilly, Liang Sun, Shaofeng Huo, Todd L Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G Walters, Iona Y Millwood, Liming Li, John C Chambers, Jaspal S Kooner, Paul Elliott, Pim van der Harst, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups...
November 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/30481674/urinary-concentrations-of-phenols-and-phthalate-metabolites-reflect-extracellular-vesicle-microrna-expression-in-follicular-fluid
#2
Rosie M Martinez, Russ Hauser, Liming Liang, Abdallah Mansur, Michal Adir, Laura Dioni, Catherine Racowsky, Valentina Bollati, Andrea A Baccarelli, Ronit Machtinger
BACKGROUND: Phenols and phthalates are potential endocrine disrupting chemicals (EDCs) that are associated with adverse health outcomes. These EDCs dysregulate a number of biomolecules and pathways, including microRNAs. MicroRNAs can be carried in transport systems called extracellular vesicles (EVs) that are present in most biofluids. EVs in the follicular fluid, which fills the ovarian follicle and influences oocyte developmental competency, carry microRNAs (EV-miRNAs) that have been associated with In Vitro Fertilization (IVF) outcomes...
November 24, 2018: Environment International
https://www.readbyqxmd.com/read/30451969/extracellular-micrornas-profile-in-human-follicular-fluid-and-ivf-outcomes
#3
Rosie M Martinez, Liming Liang, Catherine Racowsky, Laura Dioni, Abdallah Mansur, Michal Adir, Valentina Bollati, Andrea A Baccarelli, Russ Hauser, Ronit Machtinger
Encapsulated microRNAs (i.e., miRNAs within the extracellular vesicles, i.e., EV-miRNAs) have been detected in follicular fluid in both animal and human studies and different profiles have been associated with IVF cycle characteristics. However, limited studies to date have investigated other IVF outcomes, including fertilization status and embryo quality on day three". In this cohort, we performed a cross-sectional analysis on 126 women who contributed follicular fluid from a single follicle during a single IVF cycle...
November 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30428039/lipid-metabolic-networks-mediterranean-diet-and-cardiovascular-disease-in-the-predimed-trial
#4
Dong D Wang, Yan Zheng, Estefanía Toledo, Cristina Razquin, Miguel Ruiz-Canela, Marta Guasch-Ferré, Edward Yu, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Lluis Serra-Majem, Clary B Clish, Jordi Salas-Salvadó, Liming Liang, Miguel A Martínez-González, Frank B Hu
Background: Perturbed lipid metabolic pathways may play important roles in the development of cardiovascular disease (CVD). However, existing epidemiological studies have focused more on discovering individual lipid metabolites for CVD risk prediction rather than assessing metabolic pathways. Methods: This study included a subcohort of 787 participants and all 230 incident CVD cases from the PREDIMED trial. Applying a network-based analytical method, we identified lipid subnetworks and clusters from a global network of 200 lipid metabolites and linked these subnetworks/clusters to CVD risk...
November 13, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30425353/publisher-correction-allele-defined-genome-of-the-autopolyploid-sugarcane-saccharum-spontaneum-l
#5
Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua, Xiaokai Ma, Fan Zhu, Tyler Jones, Xinguang Zhu, John Bowers, Ching Man Wai, Chunfang Zheng, Yan Shi, Shuai Chen, Xiuming Xu, Jingjing Yue, David R Nelson, Lixian Huang, Zhen Li, Huimin Xu, Dong Zhou, Yongjun Wang, Weichang Hu, Jishan Lin, Youjin Deng, Neha Pandey, Melina Mancini, Dessireé Zerpa, Julie K Nguyen, Liming Wang, Liang Yu, Yinghui Xin, Liangfa Ge, Jie Arro, Jennifer O Han, Setu Chakrabarty, Marija Pushko, Wenping Zhang, Yanhong Ma, Panpan Ma, Mingju Lv, Faming Chen, Guangyong Zheng, Jingsheng Xu, Zhenhui Yang, Fang Deng, Xuequn Chen, Zhenyang Liao, Xunxiao Zhang, Zhicong Lin, Hai Lin, Hansong Yan, Zheng Kuang, Weimin Zhong, Pingping Liang, Guofeng Wang, Yuan Yuan, Jiaxian Shi, Jinxiang Hou, Jingxian Lin, Jingjing Jin, Peijian Cao, Qiaochu Shen, Qing Jiang, Ping Zhou, Yaying Ma, Xiaodan Zhang, Rongrong Xu, Juan Liu, Yongmei Zhou, Haifeng Jia, Qing Ma, Rui Qi, Zhiliang Zhang, Jingping Fang, Hongkun Fang, Jinjin Song, Mengjuan Wang, Guangrui Dong, Gang Wang, Zheng Chen, Teng Ma, Hong Liu, Singha R Dhungana, Sarah E Huss, Xiping Yang, Anupma Sharma, Jhon H Trujillo, Maria C Martinez, Matthew Hudson, John J Riascos, Mary Schuler, Li-Qing Chen, David M Braun, Lei Li, Qingyi Yu, Jianping Wang, Kai Wang, Michael C Schatz, David Heckerman, Marie-Anne Van Sluys, Glaucia Mendes Souza, Paul H Moore, David Sankoff, Robert VanBuren, Andrew H Paterson, Chifumi Nagai, Ray Ming
In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should have read "The genome assembly and gene annotation have been deposited in the NCBI database under accession number QVOL00000000, BioProject number PRJNA483885 and BioSample number SAMN09753102. The data can also be downloaded from the following link: http://www.life.illinois.edu/ming/downloads/Spontaneum_genome/ ...
November 13, 2018: Nature Genetics
https://www.readbyqxmd.com/read/30423132/plasma-acylcarnitines-and-risk-of-type-2-diabetes-in-a-mediterranean-population-at-high-cardiovascular-risk
#6
Marta Guasch-Ferré, Miguel Ruiz-Canela, Jun Li, Yan Zheng, Mònica Bulló, Dong D Wang, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Liming Liang, Christopher Papandreou, Courtney Dennis, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó
Context: The potential associations between acylcarnitine profiles and incidence of T2D, and whether acylcarnitines can be used to improve diabetes prediction remains unclear. Objective: To evaluate the associations between baseline and 1-year changes in acylcarnitines, and their diabetes predictive ability beyond traditional risk factors. Design, setting and participants: We designed a case-cohort study within the PREDIMED Study including all incident cases of T2D(n=251) and 694 randomly selected participants at baseline(follow-up:3...
November 13, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30417588/estrogen-receptor-variant-er-%C3%AE-36-promotes-tamoxifen-agonist-activity-in-glioblastoma-cells
#7
Chao Qu, Jingyun Ma, Yejun Zhang, Chao Han, Liang Huang, Liming Shen, Hongyan Li, Xiaobo Wang, Jing Liu, Wei Zou
Glioblastoma (GBM) is a highly infiltrative and malignant primary brain tumor. Despite aggressive therapy, patients with GBM have a dismal prognosis with median survival of about one year. Tamoxifen (TAM), a selective estrogen receptor modulator (SERM), has been used to treat GBM for many years. ER-α36 is a novel variant of estrogen receptor-alpha66 (ER-α66) and can mediate cell proliferation through estrogen or anti-estrogen signaling in different cancer cells. Previously, we found that ER-α36 was highly expressed in GBM and was involved in the tamoxifen-sensitivity of glioblastoma cells...
November 11, 2018: Cancer Science
https://www.readbyqxmd.com/read/30390058/author-correction-a-genome-wide-cross-trait-analysis-from-uk-biobank-highlights-the-shared-genetic-architecture-of-asthma-and-allergic-diseases
#8
Zhaozhong Zhu, Phil H Lee, Mark D Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David C Christiani, Liming Liang
In the version of this article originally published, there were two errors in the text of the second paragraph of the Methods section. In the sentence "To identify genetic variants that contribute to doctor-diagnosed asthma and allergic diseases (detailed phenotype information described in the Supplementary Note) and link them with other conditions, we performed GWASs using phenotype measures in UK Biobank participants (N = 487,409)" the number of participants should have been 150,509. In the sentence "Thus, a total of 110,361 European descendants with high-quality genotyping and complete phenotype/covariate data were used for these analyses, including 25,685 allergic diseases subjects (hay fever/allergic rhinitis or eczema, without doctor-diagnosed asthma), 14,085 asthma subjects and 76,768 controls for the analysis" the phrase "without doctor-diagnosed asthma" should have read "some with doctor-diagnosed asthma...
November 2, 2018: Nature Genetics
https://www.readbyqxmd.com/read/30364240/dietary-protein-intake-meat-consumption-and-dairy-consumption-in-the-year-preceding-pregnancy-and-during-pregnancy-and-their-associations-with-the-risk-of-gestational-diabetes-mellitus-a-prospective-cohort-study-in-southwest-china
#9
Yi Liang, Yunhui Gong, Xiao Zhang, Dagang Yang, Danqing Zhao, Liming Quan, Rong Zhou, Wei Bao, Guo Cheng
Background: Gestational diabetes mellitus (GDM) has become a public health problem in China. Objective: To examine the association of dietary protein intake before and during pregnancy with the risk of GDM. Design: Dietary intake before pregnancy and during the first and second trimesters of pregnancy was assessed using food frequency questionnaires in a prospective cohort of pregnant women. To screen GDM, participants underwent an OGTT test during 24-28 weeks of gestation. Cox proportional hazards were used to estimate RRs and 95% CIs for the associations between tertiles of dietary protein and the source of protein intake in different time windows with GDM status...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30350625/chemoenzymatic-approach-for-the-proteomics-analysis-of-mucin-type-core-1-o-glycosylation-in-human-serum
#10
Xin You, Yating Yao, Jiawei Mao, Hongqiang Qin, Xinmiao Liang, Liming Wang, Mingliang Ye
Human serum is a complex body fluid that contains various N-linked and O-linked glycoproteins. Compared with N-linked glycoproteins, the serum O-linked glycoproteins are not well-studied due to their high heterogeneity and their low abundance. Herein, we presented a novel chemoenzymatic method to analyze core-1 type of O-GalNAcylation in human serum. In this approach, the tryptic digest of serum was first subjected to PNGase F treatment to release the N-glycan and was then treated with strong acid to release sialic acid residues from mucin-type O-glycans...
November 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30349277/one-type-of-duplex-appendix-horseshoe-appendix
#11
Jin Liu, Chengyong Dong, Haibo Wang, Deguang Sun, Rui Liang, Zhenming Gao, Liming Wang
A horseshoe appendix is a subtype of duplex appendix, in which the appendix is shaped like a circle that may lead to an internal hernia and result in intestinal necrosis. This subtype is extremely rare, with only 13 cases reported worldwide to date, and easily triggers a series of medico-legal consequences due to the neglect of another infection base of the appendix. We describe a 22-year-old man who presented with a 3-day history of fever and was diagnosed with pneumonia. After receiving antibiotics for 3 days in the Department of Pneumology, he was found to have a periappendiceal abscess...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30327364/plasma-lipidomic-profiling-and-risk-of-type-2-diabetes-in-the-predimed-trial
#12
Cristina Razquin, Estefanía Toledo, Clary B Clish, Miguel Ruiz-Canela, Courtney Dennis, Dolores Corella, Christopher Papandreou, Emilio Ros, Ramon Estruch, Marta Guasch-Ferré, Enrique Gómez-Gracia, Montserrat Fitó, Edward Yu, José Lapetra, Dong Wang, Dora Romaguera, Liming Liang, Angel Alonso-Gómez, Amy Deik, Mónica Bullo, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
OBJECTIVE: Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30297971/allele-defined-genome-of-the-autopolyploid-sugarcane-saccharum-spontaneum-l
#13
Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua, Xiaokai Ma, Fan Zhu, Tyler Jones, Xinguang Zhu, John Bowers, Ching Man Wai, Chunfang Zheng, Yan Shi, Shuai Chen, Xiuming Xu, Jingjing Yue, David R Nelson, Lixian Huang, Zhen Li, Huimin Xu, Dong Zhou, Yongjun Wang, Weichang Hu, Jishan Lin, Youjin Deng, Neha Pandey, Melina Mancini, Dessireé Zerpa, Julie K Nguyen, Liming Wang, Liang Yu, Yinghui Xin, Liangfa Ge, Jie Arro, Jennifer O Han, Setu Chakrabarty, Marija Pushko, Wenping Zhang, Yanhong Ma, Panpan Ma, Mingju Lv, Faming Chen, Guangyong Zheng, Jingsheng Xu, Zhenhui Yang, Fang Deng, Xuequn Chen, Zhenyang Liao, Xunxiao Zhang, Zhicong Lin, Hai Lin, Hansong Yan, Zheng Kuang, Weimin Zhong, Pingping Liang, Guofeng Wang, Yuan Yuan, Jiaxian Shi, Jinxiang Hou, Jingxian Lin, Jingjing Jin, Peijian Cao, Qiaochu Shen, Qing Jiang, Ping Zhou, Yaying Ma, Xiaodan Zhang, Rongrong Xu, Juan Liu, Yongmei Zhou, Haifeng Jia, Qing Ma, Rui Qi, Zhiliang Zhang, Jingping Fang, Hongkun Fang, Jinjin Song, Mengjuan Wang, Guangrui Dong, Gang Wang, Zheng Chen, Teng Ma, Hong Liu, Singha R Dhungana, Sarah E Huss, Xiping Yang, Anupma Sharma, Jhon H Trujillo, Maria C Martinez, Matthew Hudson, John J Riascos, Mary Schuler, Li-Qing Chen, David M Braun, Lei Li, Qingyi Yu, Jianping Wang, Kai Wang, Michael C Schatz, David Heckerman, Marie-Anne Van Sluys, Glaucia Mendes Souza, Paul H Moore, David Sankoff, Robert VanBuren, Andrew H Paterson, Chifumi Nagai, Ray Ming
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated the assembly of 32 pseudo-chromosomes comprising 8 homologous groups of 4 members each, bearing 35,525 genes with alleles defined. The reduction of basic chromosome number from 10 to 8 in S. spontaneum was caused by fissions of 2 ancestral chromosomes followed by translocations to 4 chromosomes...
November 2018: Nature Genetics
https://www.readbyqxmd.com/read/30290618/sex-hormone-therapy-s-effect-on-dry-eye-syndrome-in-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Chao Liu, Kun Liang, Zhengxuan Jiang, Liming Tao
THE PURPOSE OF THE STUDY T: o assess the efficacy of sex hormone therapy in the treatment of dry eye syndrome in postmenopausal women.The following electronic databases were searched without language restrictions: PubMed, Embase, Cochrane, and the Chinese Biomedical Database. Two reviewers collected all the literature, which was searched for relevance in English and Chinese from January 1990 to July 2017. Both of the reviewers screened documents independently, identifying the studies that met the inclusion criteria...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30280434/application-of-six-sigma-for-evaluating-the-analytical-quality-of-tumor-marker-assays
#15
Qian Liu, Mei Fu, Fumeng Yang, Wei Liang, Chuanxi Yang, Wenjun Zhu, Liming Ma, Changxin Zhao
CONTEXT: The results of detection assays for the same specimen are usually quite different in different laboratories or when tested with different detection systems. OBJECTIVE: This study was designed to investigate the value of applying sigma metrics derived from different standards for allowable total error (TEa) in evaluating the analytical quality of tumor marker assays. METHODS: Assays were evaluated for these six tumor markers: total prostate-specific antigen (tPSA), carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), and carbohydrate antigen 153 (CA153)...
October 2, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/30244686/enteral-nutrition-feeding-in-chinese-intensive-care-units-a-cross-sectional-study-involving-116-hospitals
#16
Juan Xing, Zhongheng Zhang, Lu Ke, Jing Zhou, Bingyu Qin, Hongkai Liang, Xiaomei Chen, Wenming Liu, Zhongmin Liu, Yuhang Ai, Difeng Wang, Qiuhui Wang, Qingshan Zhou, Fusen Zhang, Kejian Qian, Dongpo Jiang, Bin Zang, Yimin Li, Xiaobo Huang, Yan Qu, Yinguang Xie, Donglin Xu, Zhiqiang Zou, Xiangde Zheng, Jianbo Liu, Feng Guo, Yafeng Liang, Qiang Sun, Hongmei Gao, Yang Liu, Ping Chang, Aibin Ceng, Rongli Yang, Gaiqi Yao, Yun Sun, Xiaorong Wang, Yi Zhang, Yichao Wen, Jian Yu, Rongqing Sun, Zhiwei Li, Shiying Yuan, Yunlin Song, Peiyang Gao, Haiyan Liu, Zhaohui Zhang, Yunfu Wu, Biao Ma, Qiang Guo, Feng Shan, Mingshi Yang, Hailing Li, Yuanfei Li, Weihua Lu, Lei Wang, Chuangyun Qian, Zhiyong Wang, Jiandong Lin, Rumin Zhang, Peng Wan, Zhiyong Peng, Yuqiang Gong, Linxi Huang, Guobao Wu, Jie Sun, Yijun Deng, Dongwu Shi, Lixin Zhou, Fachun Zhou, Qindong Shi, Xiaodong Guo, Xueyan Liu, Weidong Wu, Xiangzhong Meng, Liandi Li, Weiwei Chen, Shusheng Li, Xianyao Wan, Zhixin Chao, An Zhang, Liming Gu, Wei Chen, Jinglan Wu, Lihua Zhou, Zhenhuan Zhang, Yibing Weng, Yongshun Feng, Chunli Yang, Yongjian Feng, Sumin Zhao, Fei Tong, Dong Hao, Hui Han, Baocai Fu, Chuanyong Gong, Zhiping Li, Kunlin Hu, Qiuye Kou, Han Zhang, Jie Liu, Chuming Fan, Xin Zhou, Xiumei Chen, Junli Sun, Xuejun Zhou, Bin Song, Cheng Sun, Liyun Zhao, Xinglu Dong, Linlin Zhang, Dafei Tong, Zhiguo Pan, Chuangjie Cai, Donghao Wang, Yingjun Dong, Yuanqi Gong, Zhisong Wu, Xinke Meng, Ping Wang, Weiqin Li
BACKGROUND: There is a lack of large-scale epidemiological data on the clinical practice of enteral nutrition (EN) feeding in China. This study aimed to provide such data on Chinese hospitals and to investigate factors associated with EN delivery. METHODS: This cross-sectional study was launched in 118 intensive care units (ICUs) of 116 mainland hospitals and conducted on April 26, 2017. At 00:00 on April 26, all patients in these ICUs were included. Demographic and clinical variables of patients on April 25 were obtained...
September 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30233865/predictors-and-prognosis-of-left-ventricular-thrombus-in-post-myocardial-infarction-patients-with-left-ventricular-dysfunction-after-percutaneous-coronary-intervention
#17
Jieyun You, Xingxu Wang, Jian Wu, Liming Gao, Xiaoyan Wang, Peizhao Du, Haibo Liu, Jiming Li, Yunkai Wang, Yulu Liang, Wei Guo, Qi Zhang
Background: We aimed to investigate the predictors and prognosis of left ventricular thrombus (LVT) in patients admitted for post-myocardial infarction (MI) and left ventricular dysfunction after contemporary percutaneous coronary intervention (PCI). Methods: We prospectively enrolled 267 consecutive post-MI patients with left ventricular ejection fraction (LVEF) <0.45 based on the Shanghai East Hospital PCI database since 2012. Altogether 25 (9.36%) patients were selected as the LVT group...
August 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30191323/engineered-3d-tumour-model-for-study-of-glioblastoma-aggressiveness-and-drug-evaluation-on-a-detachably-assembled-microfluidic-device
#18
Jingyun Ma, Na Li, Yachen Wang, Liang Wang, Wenjuan Wei, Liming Shen, Yu Sun, Yang Jiao, Weigong Chen, Jing Liu
3D models of tumours have emerged as an advanced technique in pharmacology and tumour cell biology, in particular for studying malignant tumours such as glioblastoma multiforme (GBM). Herein, we developed a 3D GBM model on a detachably assembled microfluidic device, which could be used to study GBM aggressiveness and for anti-GBM drug testing. Fundamental characteristics of the GBM microenvironment in terms of 3D tissue organisation, extracellular matrices and blood flow were reproduced in vitro by serial manipulations in the integrated microfluidic device, including GBM spheroid self-assembly, embedding in a collagen matrix, and continuous perfusion culture, respectively...
September 6, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/30146690/changes-in-arginine-are-inversely-associated-with-type-2-diabetes-a-case-cohort-study-in-the-predimed-trial
#19
Edward Yu, Miguel Ruiz-Canela, Cristina Razquin, Marta Guasch-Ferré, Estefania Toledo, Dong D Wang, Christopher Papandreou, Courtney Dennis, Clary Clish, Liming Liang, Monica Bullo, Dolores Corella, Montserrat Fitó, Mario Gutiérrez-Bedmar, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V Sorlí, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0...
August 26, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30136473/-determination-of-deltamethrin-and-its-toxicity-biomarkers-in-rabbit-urine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#20
Wenqing Cao, Zhenxing Wu, Chengzhu Liang, Ping Jing, Shuhua Cui, Guipeng Yang, Liming Lin
A method was developed for the determination of biomarkers related to toxicity of deltamethrin in rabbit urine by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The target analytes in this method are as follows:deltamethrin and its two metabolites (1 R - cis )-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid (dibromochrysanthemic acid) and 3-phenoxybenzoic acid (3-PBA), and five toxic biomarkers, viz. serotonin hydrochloride (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA), 3-nitropropionic acid (3-NPA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 6-methoxyguanine...
June 8, 2018: Se Pu, Chinese Journal of Chromatography
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