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Victor Zislin, Moshe Rosenfeld
Impedance pumping is a mechanism that generates flow in a compliant vessel by repeatedly actuating the vessel asymmetrically, without employing any internal valves, blades, or other mechanisms. The net flow is obtained by establishing a constructive wave pattern. Elaborate studies of impedance pumping in a single vessel have shown that the flow rate strongly depends on the actuation frequency, as well as on other parameters, such as actuator location and amplitude, and that it operates best in the resonance mode...
August 9, 2018: Bioengineering
Eric J Berkowitz, Brent E Pleimann, Lynda E Rosenfeld
We report the case of a patient who received both appropriate and inappropriate shocks from an entirely subcutaneous implantable defibrillator (S-ICD). The inappropriate shocks were due to oversensing of chest compressions in the setting of profound post shock bradycardia. It is important to recognize that therapy from the S-ICD can not only be withheld, as previously described, but can also be inappropriately delivered during chest compressions. This article is protected by copyright. All rights reserved.
August 7, 2018: Pacing and Clinical Electrophysiology: PACE
Eric H Rosenfeld, Adam Vogel, Robert T Russell, Ilan Maizlin, Denise B Klinkner, Stephanie Polites, Barbara Gaines, Christine Leeper, Stallion Anthony, Megan Waddell, Shawn St Peter, David Juang, Rajan Thakkar, Joseph Drews, Brandon Behrens, Mubeen Jafri, Randall S Burd, Marianne Beaudin, Laurence Carmant, Richard A Falcone, Suzanne Moody, Bindi J Naik-Mathuria
PURPOSE: Determining the integrity of the pancreatic duct is important in high-grade pancreatic trauma to guide decision making for operative vs non-operative management. Computed tomography (CT) is generally an inadequate study for this purpose, and magnetic resonance cholangiopancreatography (MRCP) is sometimes obtained to gain additional information regarding the duct. The purpose of this multi-institutional study was to directly compare the results from CT and MRCP for evaluating pancreatic duct disruption in children with these rare injuries...
August 3, 2018: Pediatric Surgery International
Myrna R Rosenfeld, Josep Dalmau
Paraneoplastic neurologic syndromes (PNS) are mostly immune-mediated disorders that occur in patients with cancer. Because the same neurologic syndromes may occur without a cancer association it is important to know the likelihood of PNS, which is based in part on the syndrome and the patient's demographics and risk factors for cancer. The presence of specific antineuronal antibodies can facilitate the diagnosis and suggest treatment strategies. Although some PNS are rarely responsive to therapies, other disorders are highly treatment responsive...
August 2018: Neurologic Clinics
Stephanie D Davis, Margaret Rosenfeld, Hye-Seung Lee, Thomas W Ferkol, Scott D Sagel, Sharon D Dell, Carlos Milla, Jessica E Pittman, Adam J Shapiro, Kelli M Sullivan, Keith R Nykamp, Jeffrey P Krischer, Maimoona A Zariwala, Michael R Knowles, Margaret W Leigh
RATIONALE: In primary ciliary dyskinesia (PCD), factors leading to disease heterogeneity are poorly understood. OBJECTIVES: To describe early lung disease progression in PCD and identify associations between ultrastructural defects and genotypes with clinical phenotype. METHODS: Prospective, longitudinal (5 years), multicenter, observational study. INCLUSION CRITERIA: < 19 years at enrollment; > 2 annual study visits...
August 1, 2018: American Journal of Respiratory and Critical Care Medicine
Tiarnan D Keenan, Elvira Agrón, Amitha Domalpally, Traci E Clemons, Freekje van Asten, Wai T Wong, Ronald G Danis, SriniVas Sadda, Philip J Rosenfeld, Michael L Klein, Rinki Ratnapriya, Anand Swaroop, Frederick L Ferris, Emily Y Chew
PURPOSE: To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN: Prospective cohort study within a controlled clinical trial. PARTICIPANTS: Age-Related Eye Disease Study 2 (AREDS2) participants, aged 50-85 years. METHODS: Baseline and annual stereoscopic color fundus photographs were evaluated for GA presence and area...
July 27, 2018: Ophthalmology
Eric H Rosenfeld, Monica E Lopez, Yangyang R Yu, Caitlin A Justus, Matthew M Borges, Rincy C Mathai, Aleena Karediya, Wei Zhang, Mary L Brandt
BACKGROUND: Obtaining informed consent for surgical procedures is often compromised by patient and family educational background, complexity of the forms, and language barriers. We developed and tested a visual aid in order to improve the informed consent process for families of children with appendicitis. METHODS: Families were randomized to receive either a standard surgical consent or a standard consent plus visual aid. Univariate and multivariate analyses were performed to assess the effectiveness of adding the visual aid to the consent procedure...
July 24, 2018: American Journal of Surgery
Paul C Marcogliese, Vandana Shashi, Rebecca C Spillmann, Nicholas Stong, Jill A Rosenfeld, Mary Kay Koenig, Julián A Martínez-Agosto, Matthew Herzog, Agnes H Chen, Patricia I Dickson, Henry J Lin, Moin U Vera, Noriko Salamon, Damara Ortiz, Elena Infante, Wouter Steyaert, Bart Dermaut, Bruce Poppe, Hyung-Lok Chung, Zhongyuan Zuo, Pei-Tseng Lee, Oguz Kanca, Fan Xia, Yaping Yang, Edward C Smith, Joan Jasien, Sujay Kansagra, Gail Spiridigliozzi, Mays El-Dairi, Robert Lark, Kacie Riley, Dwight D Koeberl, Katie Golden-Grant, Shinya Yamamoto, Michael F Wangler, Ghayda Mirzaa, Dimitri Hemelsoet, Brendan Lee, Stanley F Nelson, David B Goldstein, Hugo J Bellen, Loren D M Pena
Interferon regulatory factor 2 binding protein-like (IRF2BPL) encodes a member of the IRF2BP family of transcriptional regulators. Currently the biological function of this gene is obscure, and the gene has not been associated with a Mendelian disease. Here we describe seven individuals who carry damaging heterozygous variants in IRF2BPL and are affected with neurological symptoms. Five individuals who carry IRF2BPL nonsense variants resulting in a premature stop codon display severe neurodevelopmental regression, hypotonia, progressive ataxia, seizures, and a lack of coordination...
August 2, 2018: American Journal of Human Genetics
Thaís Armangue, Marianna Spatola, Alexandru Vlagea, Simone Mattozzi, Marc Cárceles-Cordon, Eloy Martinez-Heras, Sara Llufriu, Jordi Muchart, María Elena Erro, Laura Abraira, German Moris, Luis Monros-Giménez, Íñigo Corral-Corral, Carmen Montejo, Manuel Toledo, Luis Bataller, Gabriela Secondi, Helena Ariño, Eugenia Martínez-Hernández, Manel Juan, Maria Angeles Marcos, Laia Alsina, Albert Saiz, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
BACKGROUND: Herpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to assess the frequency, symptoms, risk factors, and outcomes of this complication. METHODS: We did a prospective observational study and retrospective analysis. In the prospective observational part of this study, we included patients with herpes simplex encephalitis diagnosed by neurologists, paediatricians, or infectious disease specialists in 19 secondary and tertiary Spanish centres (Cohort A)...
July 23, 2018: Lancet Neurology
Keren Machol, Joseph Jankovic, Dhanya Vijayakumar, Lindsay C Burrage, Mahim Jain, Richard A Lewis, Gregory N Fuller, Mingchu Xu, Marta Penas-Prado, Maria K Gule-Monroe, Jill A Rosenfeld, Rui Chen, Christine M Eng, Yaping Yang, Brendan H Lee, Paolo M Moretti, Shweta U Dhar
No abstract text is available yet for this article.
August 2018: Neurology. Genetics
Tom Goren, Daniel Rosenfeld, Odran Sourdeval, Johannes Quaas
This study examines the relationships between marine stratocumulus clouds (MSC) coupling state with the ocean surface, their precipitation rate and fractional cloud cover (CF). This was possible by developing a novel methodology for satellite retrieval of the clouds coupling state. Decks of overcast MSC were reported in previous studies to break up often as their precipitation rate increases significantly, thus reducing CF and cloud radiative effect substantially. Here we show that decks of precipitating decoupled MSC have larger CF compared to similarly precipitating coupled MSC...
May 28, 2018: Geophysical Research Letters
Lindsey Rosman, Lynda E Rosenfeld, Mary L Johnston, Matthew M Burg
No abstract text is available yet for this article.
July 18, 2018: Pacing and Clinical Electrophysiology: PACE
N Hu, R Uchida, L T Tran, A Rosenfeld, Y Sakurai
This paper presents the feasibility study of a novel 3D mesa bridge microdosimeter and its use for BNCT dosimetry. The performance of the microdosimeter was studied using Monte Carlo simulation. The clinical BNCT field at Kyoto University Reactor (KUR) using both thermal and epithermal irradiation modes were used in this study. Results show that this microdosimeter can be utilised as an effective tool to measure microdosimetric spectrum in the BNCT field and experimental validation will follow once KUR is operational...
June 30, 2018: Applied Radiation and Isotopes
Aaron M Rosenfeld, Wenzhao Meng, Dora Y Chen, Bochao Zhang, Tomer Granot, Donna L Farber, Uri Hershberg, Eline T Luning Prak
B cell clones expand and contract during adaptive immune responses and can persist or grow uncontrollably in lymphoproliferative disorders. One way to monitor and track B cell clones is to perform large-scale sampling of bulk cell populations, amplifying, and sequencing antibody gene rearrangements by next-generation sequencing (NGS). Here, we describe a series of computational approaches for estimating B cell clone size in NGS immune repertoire profiling data of antibody heavy chain gene rearrangements. We define three different measures of B cell clone size-copy numbers, instances, and unique sequences-and show how these measures can be used to rank clones, analyze their diversity, and study their distribution within and between individuals...
2018: Frontiers in Immunology
M G Gorobets, L A Wasserman, A V Bychkova, M L Konstantinova, I G Plaschina, M A Rosenfeld
For the first time, with the aid of differential scanning calorimetry, the thermal denaturation of fibrinogen under induced oxidation was studied. All fibrinogen structural elements detected by DSC (D region, αC-domain, and E region) are subjected to oxidation. Structural changes in fibrinogen molecule were characterized by the denaturation temperature, denaturation enthalpy, and van't Hoff enthalpy.
May 2018: Doklady. Biochemistry and Biophysics
Donald L Chi, Margaret Rosenfeld, Lloyd Mancl, Whasun O Chung, Richard B Presland, Elise Sarvas, Marilynn Rothen, Alaa Alkhateeb, Sharon McNamara, Alan Genatossio, Isabel Virella-Lowell, Carlos Milla, JoAnna Scott
BACKGROUND: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. METHODS: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF...
July 10, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Sarah A Johnson, Mark R Ellersieck, Cheryl S Rosenfeld
Bisphenol A (BPA) is a pervasive industrial chemical used in many common household items. To examine how early exposure to BPA and ethinyl estradiol (EE, estrogen in birth control pill) might affect biparental care, effects of these chemicals in male and female California mice ( Peromyscus californicus ), who are monogamous and biparental, were examined. California mice exposed during pre- and peri-natal life to BPA at an environmentally relevant concentration or EE show later disrupted biparental behaviors...
June 2018: Heliyon
Ana Cheong, Sarah A Johnson, Emily C Howald, Mark R Ellersieck, Luísa Camacho, Sherry M Lewis, Michelle M Vanlandingham, Jun Ying, Shuk-Mei Ho, Cheryl S Rosenfeld
Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is a ubiquitous pollutant. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether exposure of Sprague-Dawley rats to 2,500 μg/kg/day BPA (BPA) or 0.5 μg/kg/day ethinyl estradiol (EE) from gestational day 6 through postnatal day 21 induces behavior-relevant gene expression and DNA methylation changes in hippocampus and hypothalamus at adulthood. RNA and DNA were isolated from both regions...
July 12, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Giordano Biasi, Marco Petasecca, Susanna Guatelli, Ebert A Martin, Garry Grogan, Benjamin Hug, Jonathan Lane, Vladimir Perevertaylo, Tomas Kron, Anatoly B Rosenfeld
PURPOSE: The challenges of accurate dosimetry for stereotactic radiotherapy (SRT) with small unflattened radiation fields have been widely reported in the literature. In this case, suitable dosimeters would have to offer a submillimeter spatial resolution. The CyberKnife® (Accuray Inc., Sunnyvale, CA, USA) is an SRT-dedicated linear accelerator (linac), which can deliver treatments with submillimeter positional accuracy using circular fields. Beams are delivered with the desired field size using fixed cones, the InCise™ multileaf collimator or a dynamic variable-aperture Iris™ collimator...
July 12, 2018: Journal of Applied Clinical Medical Physics
Daniel P Ballard, Jason Abramowitz, Daniel C Sukato, Boris Bentsianov, Richard Rosenfeld
Objective To assist otolaryngologists in counseling patients with hoarseness who would benefit from injection laryngoplasty on whether or not to perform the procedure in the office vs the operating room. Data Sources Cochrane library, CINAHL, PubMed, and EMBASE. Review Methods Systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting standards of English-language articles that compared voice outcomes for in-office and in the operating room injection laryngoplasty...
July 1, 2018: Otolaryngology—Head and Neck Surgery
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