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Jason Watterson, B Gabbe, P Dietze, A Bowring, J V Rosenfeld
BACKGROUND: The Alcohol Use Disorders Identification Test (AUDIT) is widely used for monitoring harmful alcohol consumption among high-risk populations. A number of short versions of AUDIT have been developed for use in time-constrained settings. In military populations, a range of AUDIT variations have been used, but the optimal combination of AUDIT items has not been determined. METHODS: A total of 952 participants (80% male), recruited as part of a wider study, completed the AUDIT-10...
October 18, 2018: Journal of the Royal Army Medical Corps
Zakiya S Al-Rahbi, Dean L Cutajar, Peter Metcalfe, Anatoly B Rosenfeld
PURPOSE: To investigate the feasibility of using the brass mesh bolus as an alternative to tissue- equivalent bolus for post mastectomy chest wall cancer by characterizing the dosimetric effects of the 2-mm fine brass bolus on both the skin dose, the dose at depth and spatial distribution. MATERIALS AND METHODS: Surface dose and percent depth dose data were acquired for a 6 MV photon beam in a solid water phantom using MOSkin™, Gafchromic EBT3 film and an Advanced Markus ionization chamber...
October 2018: Physica Medica: PM
Levi Madden, James Archer, Enbang Li, Dean Wilkinson, Anatoly Rosenfeld
The irradiation of scintillator-fiber optic dosimeters by clinical LINACs results in the measurement of scintillation and Cerenkov radiation. In scintillator-fiber optic dosimetry, the scintillation and Cerenkov radiation responses are separated to determine the dose deposited in the scintillator volume. Artificial neural networks (ANNs) were trained and applied in a novel single probe method for the temporal separation of scintillation and Cerenkov radiation. Six dose profiles were measured using the ANN, with the dose profiles compared to those measured using background subtraction and an ionisation chamber...
October 2018: Physica Medica: PM
Daniel C Sukato, Daniel P Ballard, Jason M Abramowitz, Richard M Rosenfeld, Stefan Mlot
OBJECTIVE: The aim of this systematic review is to compare the perioperative outcomes of robotic versus conventional neck dissection in patients with head and neck malignancy. METHODS: An electronic search of PubMed, Web of Science, and EMBASE databases was conducted. We included studies with direct comparisons of robotic and open neck dissections and performed dual, independent data extraction for primary outcomes of nodal yield, recurrence rate, subjective cosmetic assessment, operative time, length of stay, and rates of perioperative complications...
October 16, 2018: Laryngoscope
Jason Anthony Vander Heiden, Susanna Marquez, Nishanth Marthandan, Syed Ahmad Chan Bukhari, Christian E Busse, Brian Corrie, Uri Hershberg, Steven H Kleinstein, Frederick A Matsen Iv, Duncan K Ralph, Aaron M Rosenfeld, Chaim A Schramm, Scott Christley, Uri Laserson
Increased interest in the immune system's involvement in pathophysiological phenomena coupled with decreased DNA sequencing costs have led to an explosion of antibody and T cell receptor sequencing data collectively termed "adaptive immune receptor repertoire sequencing" (AIRR-seq or Rep-Seq). The AIRR Community has been actively working to standardize protocols, metadata, formats, APIs, and other guidelines to promote open and reproducible studies of the immune repertoire. In this paper, we describe the work of the AIRR Community's Data Representation Working Group to develop standardized data representations for storing and sharing annotated antibody and T cell receptor data...
2018: Frontiers in Immunology
K Koo, A D Liddle, P S Pastides, P F Rosenfeld
BACKGROUND: Modern designs of total ankle arthroplasty (TAA) have the potential to treat symptomatic ankle OA without adversely affecting ankle biomechanics. We present the mid-term results of a modern, mobile-bearing TAA design. METHODS: TAA was performed in 50 consecutive patients (55 ankles) in an independent, prospective, single-centre series. Implant survival, patient-reported outcome measures (PROMs) and radiographic outcomes are presented at a mean of five years (range 2-10...
April 16, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, Jeffrey Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Rowe
BACKGROUND: An association between obstructive sleep apnea (OSA) and Alzheimer's disease has been suggested but little is known about amyloid-β and tau deposition in this syndrome. OBJECTIVE: To determine amyloid and tau burden and cognitive function in OSA in comparison to those without a diagnosis of OSA. METHODS: The status of OSA was determined by asking participants about history of polysomnographic diagnosis of OSA and the use of Continuous Positive Airway Pressure (CPAP)...
October 8, 2018: Journal of Alzheimer's Disease: JAD
Charles R Rosenfeld, Grant Shafer, Lisa M Scheid, L Steven Brown
OBJECTIVE: To determine the validity of screening and serial neutrophil counts in predicting the absence/presence of late-onset sepsis (LOS) in infants with central venous catheters. STUDY DESIGN: Retrospective study of infants admitted to the neonatal intensive care unit (2009-2013) at Parkland Hospital with a central venous catheter and ≥1 LOS evaluations. Infants were categorized as proven or suspect LOS or uninfected based on results of blood cultures, clinical illness, and duration of antibiotics...
October 11, 2018: Journal of Pediatrics
Ming Lui, Kelvin F H Lui, Alan C-N Wong, J Peter Rosenfeld
Criminal investigation often involves finding out what a suspect knows about people, such as victims and confederates, who are involved in the crime. This study explored the possibility of determining a person's recognition of other individuals by analyzing the steady-state visually evoked potentials (SSVEP) triggered by visual oscillations of familiar and unfamiliar faces. In our study, 23 adult (10 men) participants gave subjective familiarity ratings (in a 7-point Likert scale) of >300 celebrities' and strangers' faces...
November 2018: International Journal of Psychophysiology
Elizabeth M Webber, Jessica Ezzell Hunter, Leslie G Biesecker, Adam H Buchanan, Elizabeth V Clarke, Erin Currey, Orit Dagan-Rosenfeld, Kristy Lee, Noralane M Lindor, Christa Lese Martin, Aleksandar Milosavljevic, Kathleen F Mittendorf, Kristin R Muessig, Julianne M O'Daniel, Ronak Y Patel, Erin M Ramos, Shannon Rego, Anne M Slavotinek, Nara Lygia M Sobriera, Meredith A Weaver, Marc S Williams, James P Evans, Katrina A B Goddard
The use of genome-scale sequencing allows for identification of genetic findings beyond the original indication for testing (secondary findings). The ClinGen Actionability Working Group's (AWG) protocol for evidence synthesis and semi-quantitative metric scoring evaluates four domains of clinical actionability for potential secondary findings: severity and likelihood of the outcome, and effectiveness and nature of the intervention. As of February 2018, the AWG has scored 127 genes associated with 78 disorders (up-to-date topics/scores are available at www...
November 2018: Human Mutation
Joseph Olson, J Peter Rosenfeld, Taewoo Kim, Ella Perrault
Behavioral reaction time (RT) to key (probe) stimuli in a concealed information test (CIT) is usually greater than RT to irrelevant stimuli, and this difference has been utilized as a sign of recognition of concealed information. The ability to voluntarily increase irrelevant RT would appear to be an obvious countermeasure to the RT-based CIT. This study examined the effect of such countermeasure use on the simultaneously recorded P300 event related potentials. There were two blocks of trials in the present study, based on the 3-stimulus protocol...
October 7, 2018: International Journal of Psychophysiology
Daniel P Ballard, Daniel C Sukato, Alisa Timashpolsky, Seilesh C Babu, Richard M Rosenfeld, Matthew Hanson
Objective Several surgical interventions are offered to patients with Ménière's disease (MD) who fail medical management. Although outcomes have historically been reported according to American Academy of Otolaryngology-Head and Neck Surgery guidelines, patient-reported outcome measures (PROMs) are increasingly used to evaluate treatments. This study reviews PROMs used to assess surgical treatments for MD and compares the effect of each intervention based on PROM scores. Data Sources PubMed, EMBASE, CINAHL, and Web of Science...
October 9, 2018: Otolaryngology—Head and Neck Surgery
Aaron M Rosenfeld, Wenzhao Meng, Eline T Luning Prak, Uri Hershberg
ImmuneDB is a system for storing and analyzing high-throughput immune receptor sequencing data. Unlike most existing tools, which utilize flat-files, ImmuneDB stores data in a well-structured MySQL database, enabling efficient data queries. It can take raw sequencing data as input and annotate receptor gene usage, infer clonotypes, aggregate results, and run common downstream analyses such as calculating selection pressure and constructing clonal lineages. Alternatively, pre-annotated data can be imported and analyzed data can be exported in a variety of common Adaptive Immune Receptor Repertoire (AIRR) file formats...
2018: Frontiers in Immunology
Daniel C Sukato, Alisa Timashpolsky, George Ferzli, Richard M Rosenfeld, Eli A Gordin
Objective The aim of this systematic review is to compare the surgical outcomes of supraclavicular artery island flap (SCAIF) and free tissue transfer (FTT) in head and neck reconstruction. Data Sources PubMed, Web of Science, and EMBASE databases. Review Methods Independent screening and data extraction were performed by 2 authors. Only studies that directly compared SCAIF and FTT were included. Data were pooled with random-effects meta-analysis to determine the standardized mean differences (SMDs), risk differences, and 95% confidence intervals (CIs)...
October 9, 2018: Otolaryngology—Head and Neck Surgery
Kyle A Metz, Xinchen Teng, Isabelle Coppens, Heather M Lamb, Bart E Wagner, Jill A Rosenfeld, Xianghui Chen, Yu Zhang, Hee Jong Kim, Michael E Meadow, Tim Sen Wang, Edda D Haberlandt, Glenn W Anderson, Esther Leshinsky-Silver, Weimin Bi, Thomas C Markello, Marsha Pratt, Nawal Makhseed, Adolfo Garnica, Noelle R Danylchuk, Thomas A Burrow, Parul Jayakar, Dianalee McKnight, Satish Agadi, Hatha Gbedawo, Christine Stanley, Michael Alber, Isabelle Prehl, Katrina Peariso, Min Tsui Ong, Santosh R Mordekar, Michael J Parker, Daniel Crooks, Pankaj B Agrawal, Gerard T Berry, Tobias Loddenkemper, Yaping Yang, Gustavo H B Maegawa, Abdel Aouacheria, Janet G Markle, James A Wohlschlegel, Adam L Hartman, J Marie Hardwick
OBJECTIVE: Several small case series identified KCTD7 mutations in patients with a rare autosomal recessive disorder designated progressive myoclonic epilepsy (EPM3) and neuronal ceroid lipofuscinosis (CLN14). Despite the name KCTD (potassium channel tetramerization domain), KCTD protein family members lack predicted channel domains. We sought to translate insight gained from yeast studies to uncover disease mechanisms associated with deficiencies in KCTD7 of unknown function. METHODS: Novel KCTD7 variants in new and published patients were assessed for disease causality using genetic analyses, cell-based functional assays of patient fibroblasts and knockout yeast, and electron microscopy of patient samples...
October 8, 2018: Annals of Neurology
Emily Y Chew, Traci E Clemons, Glenn J Jaffe, Charles A Johnson, Sina Farsiu, Eleonora M Lad, Robyn Guymer, Philip Rosenfeld, Jean-Pierre Hubschman, Ian Constable, Henry Wiley, Lawrence J Singerman, Mark Gillies, Grant Comer, Barbara Blodi, Dean Eliott, Jiong Yan, Alan Bird, Martin Friedlander
PURPOSE: To test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF) on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy. DESIGN: Randomized sham-controlled clinical trial PARTICIPANTS: 99 study eyes of 67 eligible participants were enrolled. METHODS: Single-masked randomized clinical trial of 24 months duration conducted May 2014 to April 2017 in eleven clinical centers of retinal specialists in United States and Australia...
October 4, 2018: Ophthalmology
K Bogusz, M Tehei, D Cardillo, M Lerch, A Rosenfeld, S X Dou, H K Liu, K Konstantinov
Here we report the extreme toxicity in vitro of Bi(OH)3 and α-Bi2 O3 nanoparticles (NPs), obtained through a facile synthesis with an average single particle size of 6-10 nm, tested on malignant gliosarcoma 9L and MCF-7 human breast cancer cells. For both nanomaterials, clonogenic assays reveal a mortality of over 90% in 9L and MCF-7 cells for a concentration of 50 μg/mL after incubation for 24 h. Moreover, the NPs show a significant mortality of up to 60% in the malignant cells at the very low concentration of 6...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Thi Tuyet Mai Nguyen, Yoshiko Murakami, Kristen M Wigby, Nissan V Baratang, Justine Rousseau, Anik St-Denis, Jill A Rosenfeld, Stephanie C Laniewski, Julie Jones, Alejandro D Iglesias, Marilyn C Jones, Diane Masser-Frye, Angela E Scheuerle, Denise L Perry, Ryan J Taft, Françoise Le Deist, Miles Thompson, Taroh Kinoshita, Philippe M Campeau
Inherited GPI deficiencies (IGDs) are a subset of congenital disorders of glycosylation that are increasingly recognized as a result of advances in whole-exome sequencing (WES) and whole-genome sequencing (WGS). IGDs cause a series of overlapping phenotypes consisting of seizures, dysmorphic features, multiple congenital malformations, and severe intellectual disability. We present a study of six individuals from three unrelated families in which WES or WGS identified bi-allelic phosphatidylinositol glycan class S (PIGS) biosynthesis mutations...
October 4, 2018: American Journal of Human Genetics
Lara Pavageau, Charles R Rosenfeld, Roy Heyne, L Steven Brown, Jenna Whitham, Cheryl Lair, Luc P Brion
BACKGROUND: The lack of a valid and safe method for measuring length in critically ill preterm neonates has led to a primary focus on weight gain. LOCAL PROBLEM: Paucity of valid length measurements, precluding the accurate analysis of growth patterns. METHODS: Quality improvement project among infants < 29 weeks or small for gestational age < 35 weeks with embedded validation of (1) a caliper (infantometer) for length measurements and (2) length measurements during the first week to estimate birth length...
September 28, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Werner F Blum, Jürgen Klammt, Serge Amselem, Heike M Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J Child, Christine Jones, Alan G Zimmermann, Charmian A Quigley, Gordon B Cutler, Cheri L Deal, Jan Lebl, Ron G Rosenfeld, John S Parks, Roland W Pfäffle
No abstract text is available yet for this article.
September 25, 2018: EBioMedicine
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