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https://www.readbyqxmd.com/read/28936037/comparison-of-resistance-to-fracture-between-three-types-of-permanent-restorations-subjected-to-shear-force-an-in-vitro-study
#1
Ramin Atash, Maiyas Arab, Hadrien Duterme, Sibel Cetik
INTRODUCTION: Our study's objective was to compare resistance to fracture between endocrown and conventional post and core restorations when subjected to shear force. MATERIALS AND METHODS: Thirty human mandibular premolars were extracted for orthodontic reasons, endodontically treated, and restored using three different methods: endocrown, glass fiber post and composite resin core, and metal post. All the crowns were made from IPS e.max ceramic. Shear forces were applied to these restorations using a test machine until breakage...
July 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28931519/beta-cell-replacement-in-mice-using-human-type-1-diabetes-nuclear-transfer-embryonic-stem-cells
#2
Lina Sui, Nichole Danzl, Sean R Campbell, Ryan Viola, Damian Williams, Yuan Xing, Yong Wang, Neil Phillips, Greg Poffenberger, Bjarki Johannesson, Jose Oberholzer, Alvin C Powers, Rudolph L Leibel, Xiaojuan Chen, Megan Sykes, Dieter Egli
Beta cells derived from stem cells hold great promise for cell replacement therapy for diabetes. Here we examine the ability of nuclear transfer embryonic stem cells (NT-ES) derived from a type 1 diabetes patient to differentiate into beta cells, and provide a source of autologous islets for cell replacement. NT-ES cells differentiate in vitro with an average efficiency of 55% into C-peptide-positive cells, expressing markers of mature beta cells, including MAFA and NKX6.1. Upon transplantation in immunodeficient mice, grafted cells form vascularized islet-like structures containing MAFA/C-peptide-positive cells...
September 20, 2017: Diabetes
https://www.readbyqxmd.com/read/28928646/cortical-activation-during-action-observation-action-execution-and-interpersonal-synchrony-in-adults-a-functional-near-infrared-spectroscopy-fnirs-study
#3
Anjana N Bhat, Michael D Hoffman, Susanna L Trost, McKenzie L Culotta, Jeffrey Eilbott, Daisuke Tsuzuki, Kevin A Pelphrey
Introduction: Humans engage in Interpersonal Synchrony (IPS) as they synchronize their own actions with that of a social partner over time. When humans engage in imitation/IPS behaviors, multiple regions in the frontal, temporal, and parietal cortices are activated including the putative Mirror Neuron Systems (Iacoboni, 2005; Buxbaum et al., 2014). In the present study, we compared fNIRS-based cortical activation patterns across three conditions of action observation ("Watch" partner), action execution ("Do" on your own), and IPS (move "Together")...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28927922/retrospective-clinical-evaluation-of-ceramic-onlays-placed-by-dental-students
#4
Jennifer J Archibald, Gildo Coelho Santos, Maria Jacinta Moraes Coelho Santos
STATEMENT OF PROBLEM: Indirect restorations with partial or complete occlusal surface coverage have been recommended to restore teeth with weakened walls in order to prevent cusp fracture. The success of these restorations when performed by dental students is unknown. PURPOSE: The purpose of this retrospective study was to evaluate the clinical performance of adhesively bonded ceramic onlay restorations placed by third- and fourth-year dental students. MATERIAL AND METHODS: Sixty-five ceramic onlays were placed in patients between 2009 and 2015...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28926971/mini-review-the-contribution-of-intermediate-phenotypes-to-gxe-effects-on-disorders-of-body-composition-in-the-new-omics-era
#5
REVIEW
Edna J Nava-Gonzalez, Esther C Gallegos-Cabriales, Irene Leal-Berumen, Raul A Bastarrachea
Studies of gene-environment (GxE) interactions describe how genetic and environmental factors influence the risk of developing disease. Intermediate (molecular or clinical) phenotypes (IPs) are traits or metabolic biomarkers that mediate the effects of gene-environment influences on risk behaviors. Functional systems genomics discovery offers mechanistic insights into how DNA variations affect IPs in order to detect genetic causality for a given disease. Disorders of body composition include obesity (OB), Type 2 diabetes (T2D), and osteoporosis (OSTP)...
September 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28925367/generation-of-integration-free-induced-pluripotent-stem-cells-gzhmui001-a-by-reprogramming-peripheral-blood-mononuclear-cells-from-a-47-xxx-syndrome-patient
#6
Yuchang Chen, Zhanhui Ou, Bing Song, Yexing Xian, Shuming Ouyang, Yuhuan Xie, Yanting Xue, Xiaofang Sun
47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease...
August 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28924250/command-electro-optical-switching-of-photoaligned-liquid-crystal-on-photopatterned-graphene
#7
Andrii Varanytsia, Liang-Chy Chien
We report command electro-optical switching on photolithographically-patterned graphene into a high-density electrode pattern for a high-transmission in-plane-switching (IPS) liquid crystal device. A highly-effective liquid crystal photoalignment method is used to maximize the field-driven optical contrast of a prototyped device. A non-contact and low-temperature photoalignment allows delicate surface treatment required for successful processing of graphene layer into an IPS electrode structure. Electro-optic performance of the graphene-based single pixel laboratory IPS prototype demonstrates the application potential of graphene for liquid crystal electro-optic devices with complex and high-definition electrode patterns...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923894/h-ipse-is-a-pathogen-secreted-host-nucleus-infiltrating-protein-infiltrin-expressed-exclusively-by-the-schistosoma-haematobium-egg-stage
#8
Luke F Pennington, Abdulaziz Alouffi, Evaristus C Mbanefo, Debalina Ray, David M Heery, Theodore S Jardetzky, Michael H Hsieh, Franco H Falcone
Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with S. mansoni infections, the pathology in urogenital schistosomiasis is mainly related to the egg stage, which induces granulomatous inflammation of affected tissues. Schistosoma eggs and their secretions have been studied extensively for the related S. mansoni organism which is more amenable to laboratory studies. Indeed, we have shown that IPSE/alpha-1 (M-IPSE herein), a major protein secreted from S ...
September 18, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28923549/color-stability-of-lithium-disilicate-ceramics-after-aging-and-immersion-in-common-beverages
#9
Eleni-Sotiria Palla, Eleana Kontonasaki, Nikolaos Kantiranis, Lambrini Papadopoulou, Triantafyllia Zorba, Konstantinos M Paraskevopoulos, Petros Koidis
STATEMENT OF PROBLEM: The color of an esthetic restoration and its color stability are important for long-term success. However, the impact of common beverages on lithium disilicate ceramic is not well known. PURPOSE: The purpose of this in vitro study was to investigate color variations of lithium disilicate ceramics after thermal cycling (TC) and immersion in commonly consumed beverages. MATERIAL AND METHODS: A total of 288 specimens (1×10×10 mm) were fabricated from IPS e-max computer-aided design (CAD) (n=72), IPS e-max CERAM ([CER] n=72), IPS e-max Press with glazing ([PG] n=72), and IPS e-max Press without glazing ([PNG] n=72) according to the manufacturer's instructions...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28923546/influence-of-implant-abutment-material-and-ceramic-thickness-on-optical-properties
#10
Bundhit Jirajariyavej, Peeraphorn Wanapirom, Chuchai Anunmana
STATEMENT OF PROBLEM: Anterior shade matching is an essential factor influencing the esthetics of a ceramic restoration. Dentists face a challenge when the color of an implant abutment creates an unsatisfactory match with the ceramic restoration or neighboring teeth. PURPOSE: The purpose of this in vitro study was to evaluate the influence of abutment material and ceramic thickness on the final color of different ceramic systems. MATERIAL AND METHODS: Four experimental and control ceramic specimens in shade A3 were cut from IPS e...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28922739/o-glcnac-transferase-regulates-transcriptional-activity-of-human-oct4
#11
Sandii Constable, Jae-Min Lim, Krithika Vaidyanathan, Lance Wells
O-linked β-N-acetylglucosamine (O-GlcNAc) is a single sugar modification found on many different classes of nuclear and cytoplasmic proteins. Addition of this modification, by the enzyme O-linked N-acetylglucosamine transferase (OGT), is dynamic and inducible. One major class of proteins modified by O-GlcNAc is transcription factors. O-GlcNAc regulates transcription factor properties through a variety of different mechanisms including localization, stability and transcriptional activation. Maintenance of embryonic stem (ES) cell pluripotency requires tight regulation of several key transcription factors, many of which are modified by O-GlcNAc...
October 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28918520/derivation-of-human-induced-pluripotent-stem-cell-ipsc-lines-and-mechanism-of-pluripotency-historical-perspective-and-recent-advances
#12
REVIEW
Arvind Chhabra
Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major technological breakthrough in the field of regenerative medicine; it also triggered a passionate debate about the ethical issues associated with the utilization of human embryos for derivation of hESC lines. Successful derivation of induced pluripotent stem cell (iPS) lines from human somatic cells with defined reprogramming factors by Shinya Yamanaka`s group in 2007 was another breakthrough that generated enormous excitement and hope for the development of donor-specific personalized cell replacement therapies (CRT) without the ethical dilemma associated with it...
September 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28918302/a-practical-guide-to-systematic-literature-reviews-and-meta-analyses-in-infection-prevention-planning-challenges-and-execution
#13
Marin L Schweizer, Rajeshwari Nair
Systematic literature reviews and meta-analyses are important research designs used to summarize and derive conclusions about the collective evidence on a focused research question in a structured, reproducible manner. The goal of this Methodology Minute is to describe how to conduct a systematic literature review and meta-analysis using a step-by-step approach to help infection preventionists (IPs) and others in the field perform their own systematic literature review and meta-analysis, and to critically evaluate published systematic literature reviews and meta-analyses...
September 13, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28917865/physicochemical-and-structural-properties-of-pregelatinized-starch-prepared-by-improved-extrusion-cooking-technology
#14
Yunfei Liu, Jun Chen, Shunjing Luo, Cheng Li, Jiangping Ye, Chengmei Liu, Robert G Gilbert
Pregelatinized starch was made from indica rice starch using a so-called "improved extrusion cooking technology" (IECT) under 30%-70% moisture content. IECT-pregelatinized starch (IPS) had higher water solubility and water absorbability compared to native starch at low temperature. For pasting properties, the breakdown and setback viscosities of IPS were significantly (p<0.05) lower than native starch, suggesting improved gel stability and reduced short-term retrogradation. The rice starch granules lost their integrity in IPS, and formed a honeycomb-like structure with increased moisture content in the raw material...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28914820/indoor-positioning-system-based-on-a-psd-detector-precise-positioning-of-agents-in-motion-using-aoa-techniques
#15
David Rodríguez-Navarro, José Luis Lázaro-Galilea, Álvaro De-La-Llana-Calvo, Ignacio Bravo-Muñoz, Alfredo Gardel-Vicente, Georgios Tsirigotis, Juan Iglesias-Miguel
Here, we present an indoor positioning system (IPS) for detecting mobile agents based on a single Position Sensitive Device sensor (PSD) sited in the environment and InfraRed Emitter Diode (IRED) located on mobile agents. The main goal of the work is to develop an alternative IPS to other sensing technologies, cheaper, easier to install and with a low computational load to obtain a high rate of measurements per second. The proposed IPS has the capacity to accurately determine 3D position from the angle of arrival (AoA) of the signal received at the PSD sensor...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28913890/interfacial-fracture-toughness-of-adhesive-resin-cement-lithium-disilicate-resin-composite-blocks
#16
Samer Mesmar, N Dorin Ruse
PURPOSE: Resin composite blocks (RCB) are advocated as alternative to ceramic blocks (CB). Prior to use, adherence to these materials should characterized. This study aimed to test the null hypothesis (H0 ) that material and surface treatment combinations do not influence interfacial fracture toughness (KIC ) of a self-cured adhesive resin cement [RelyX Ultimate (RXU)] to RCB or CB, under nonaged and aged conditions. MATERIALS AND METHODS: Two RCB, Lava Ultimate (LU) and Enamic (EN), and one CB, IPS e...
September 15, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28911317/generation-of-ips-derived-model-cells-for-analyses-of-hair-shaft-differentiation
#17
Takumi Kido, Tomoatsu Horigome, Minori Uda, Naoki Adachi, Yohei Hirai
Biological evaluation of hair growth/differentiation activity in vitro has been a formidable challenge, primarily due to the lack of relevant model cell systems. To solve this problem, we generated a stable model cell line in which successive differentiation via epidermal progenitors to hair components is easily inducible and traceable. Mouse induced pluripotent stem (iPS) cell-derived cells were selected to stably express a tetracycline (Tet)-inducible bone morphogenic protein-4 (BMP4) expression cassette and a luciferase reporter driven by a hair-specific keratin 31 gene (krt31) promoter (Tet-BMP4-KRT31-Luc iPS)...
September 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28910748/local-functional-connectivity-density-is-closely-associated-with-the-response-of-electroconvulsive-therapy-in-major-depressive-disorder
#18
Jiaojian Wang, Qiang Wei, Xinru Yuan, Xiaoyan Jiang, Jinping Xu, Xiaoqin Zhou, Yanghua Tian, Kai Wang
BACKGROUND: Electroconvulsive therapy (ECT) has been demonstrated to be an effective treatment of major depressive disorder (MDD). However, the neuroanatomical basis of response to ECT is still largely unknown. METHODS: In present study, we used functional connectivity density (FCD) and resting-state functional connectivity (RSFC) to identify the relationship between the changes of resting-state activities and ECT responses in 23 MDD patients before and after ECT...
September 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28901676/neural-mechanisms-of-motion-perceptual-learning-in-noise
#19
Nihong Chen, Junshi Lu, Hanyu Shao, Xuchu Weng, Fang Fang
Practice improves our perceptual ability. However, the neural mechanisms underlying this experience-dependent plasticity in adult brain remain unclear. Here, we studied the long-term neural correlates of motion perceptual learning. Subjects' behavioral performance and BOLD signals were tracked before, immediately after, and 2 weeks after practicing a motion direction discrimination task in noise over six daily sessions. Parallel to the specificity and persistency of the behavioral learning effect, we found that training sharpened the cortical tuning in MT, and enhanced the connectivity strength from MT to the intraparietal sulcus (IPS, a motion decision-making area)...
September 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28895148/critical-roles-of-hmagea2-in-induced-pluripotent-stem-cell-pluripotency-proliferation-and-differentiation
#20
Song Park, Yonghun Sung, Jain Jeong, Minjee Choi, Jinhee Lee, Wookbong Kwon, Soyoung Jang, Si Jun Park, Jae Young Kim, Sung Hyun Kim, Duhak Yoon, Zae Young Ryoo, Myoung Ok Kim
Induced pluripotent stem (iPS) cells are important for clinical application and stem cell research. Although human melanoma-associated antigen A2 (hMAGEA2) expression is known to affect differentiation in embryonic stem cells, its specific role in iPS cells remains unclear. To evaluate the function of hMAGEA2 and its characteristics in iPS cells, we produced hMAGEA2-overexpressing iPS cells from hMAGEA2-overexpressing transgenic mice. Although the iPS cells with overexpressed hMAGEA2 did not differ in morphology, their pluripotency, and self-renewal related genes (Nanog, Oct3/4, Sox2, and Stat3), expression level was significantly upregulated...
September 11, 2017: Cell Biochemistry and Function
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