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https://www.readbyqxmd.com/read/29143397/marginal-fit-comparison-of-cad-cam-crowns-milled-from-two-different-materials
#1
Atousa Azarbal, Mohsen Azarbal, Robert L Engelmeier, Thomas C Kunkel
PURPOSE: To evaluate the marginal fit of CAD/CAM copings milled from hybrid ceramic (Vita Enamic) blocks and lithium disilicate (IPS e.max CAD) blocks, and to evaluate the effect of crystallization firing on the marginal fit of lithium disilicate copings. MATERIALS AND METHODS: A standardized metal die with a 1-mm-wide shoulder finish line was imaged using the CEREC AC Bluecam. The coping was designed using CEREC 3 software. The design was used to fabricate 15 lithium disilicate and 15 hybrid ceramic copings...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29143183/micrornas-important-regulators-of-induced-pluripotent-stem-cell-generation-and-differentiation
#2
REVIEW
Zhao-Lin Zeng, Xiao-Long Lin, Li-Lan Tan, Ya-Mi Liu, Kai Qu, Zuo Wang
Induced pluripotent stem (iPS) cells can differentiate into nearly all types of cells. In contrast to embryonic stem cells, iPS cells are not subject to immune rejection because they are derived from a patient's own cells without ethical concerns. These cells can be used in regenerative medical techniques, stem cell therapy, disease modelling and drug discovery investigations. However, this application faces many challenges, such as low efficiency, slow generation time, partially reprogrammed colonies and tumourigenicity...
November 15, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29141793/information-processing-deficits-as-a-driving-force-for-memory-impairment-in-ms-a-cross-sectional-study-of-memory-functions-and-mri-in-early-and-late-stage-ms
#3
Wolfgang Köhler, Martin Fischer, Peter Bublak, Jürgen H Faiss, Frank Hoffmann, Annett Kunkel, Michael Sailer, Matthias Schwab, Erhard Stadler, Uwe K Zettl, Iris-Katharina Penner
BACKGROUND: Memory impairment (MI) is a common symptom of MS. Previous studies were conflicting in respect to the possible existence of early MI and the role of hippocampal atrophy. The objective of this study was to investigate MI and structural MRI correlates in homogenous groups of early and late MS, controlling for a potential information-processing speed (IPS) deficit, and utilizing multiple memory test paradigms. METHODS: 152 individually matched subjects were recruited: early MS (EMS, N = 25, disease duration 1...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29138539/patient-reported-benefits-from-patient-organization-magazines-and-internet-based-peer-support-in-m%C3%A3-ni%C3%A3-re-s-disease
#4
Vinaya Manchaiah, Ilmari Pyykkö, Jing Zou, Hilla Levo, Erna Kentala
Objectives: To facilitate self-help, the Finnish Ménière's Federation (FMF) provides various kinds of support to persons with Ménière's disease (MD), which includes patient magazines (PM) and Internet-based peer support (iPS). The current study aimed to evaluate the benefits reported by MD patients in terms of PM and iPS. Method: The study used a cross-sectional survey design with a mixture of structured and open-ended questions administered online. A sample of 185 patients from the FMF membership database provided complete data...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29137988/tms-eeg-reveals-hemispheric-asymmetries-in-top-down-influences-of-posterior-intraparietal-cortex-on-behavior-and-visual-event-related-potentials
#5
Mika Koivisto, Simone Grassini, Mikko Hurme, Niina Salminen-Vaparanta, Henry Railo, Victor Vorobyev, Jussi Tallus, Teemu Paavilainen, Antti Revonsuo
Clinical data and behavioral studies using transcranial magnetic stimulation (TMS) suggest right-hemisphere dominance for top-down modulation of visual processing in humans. We used concurrent TMS-EEG to directly test for hemispheric differences in causal influences of the right and left intraparietal cortex on visual event-related potentials (ERPs). We stimulated the left and right posterior part of intraparietal sulcus (IPS1) while the participants were viewing and rating the visibility of bilaterally presented Gabor patches...
November 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29136536/on-the-bright-side-of-a-forest-pest-the-metabolic-potential-of-bark-beetles-bacterial-associates
#6
Anna Fabryová, Martin Kostovčík, Alexandra Díez-Méndez, Alejandro Jiménez-Gómez, Lorena Celador-Lera, Zaki Saati-Santamaría, Hana Sechovcová, Esther Menéndez, Miroslav Kolařik, Paula García-Fraile
Bark beetles reproduce and overwinter under the bark of trees, and are associated with bacteria that may influence the fitness of their hosts. As regard the aim of this study was to test the metabolic potential of bacterial strains, isolated from the bark beetle species Cryphalus piceae, Ips typographus and Pityophthorus pityophthorus and collected in the Czech Republic from fir, spruce and pine trees, respectively, to degrade plant cell compounds. The bacterial strains were identified as belonging to the genera Curtobacterium, Erwinia, Pantoea, Pseudomonas, Rahnella, Staphylococcus, and Yersinia...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29136202/a-conceptual-framework-for-cell-identity-transitions-in-plants
#7
Idan Efroni
Multicellular organisms develop from a single cell that proliferates to form different cell types with specialized functions. Sixty years ago, Waddington's suggested the "epigenetic landscape" as a useful metaphor for the process. According to this view, cells move through a rugged identity space along genetically-encoded trajectories, until arriving at one of possible final fates. In plants in particular, these trajectories also have strong spatial correlates, as cell identity is intimately linked to its relative position within the plant...
November 9, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29135426/integrated-supported-employment-for-people-with-schizophrenia-in-mainland-china-a-randomized-controlled-trial
#8
Guo Fu Zhang, Chi Man Tsui, Aisia Jiang Bo Lu, Li Bo Yu, Hector Wing Hong Tsang, Da Li
OBJECTIVE: In this randomized controlled trial, we investigated the effectiveness of integrated supported employment (ISE) compared with individual placement and support (IPS) and traditional vocational rehabilitation (TVR) for people with schizophrenia in mainland China. METHOD: One hundred and sixty-two participants with schizophrenia were randomly assigned to ISE (n = 54), IPS (n = 54), or TVR (n = 54). Blinded assessments of employment status, job tenure, and psychological outcomes were conducted at admission; completion of the 3-mo program; and follow-up at 7, 11, and 15 mo...
November 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29128550/neural-correlates-of-quantity-processing-of-chinese-numeral-classifiers
#9
One-Soon Her, Ying-Chun Chen, Nai-Shing Yen
Linguistic analysis suggests that numeral classifiers carry quantity information. However, previous neuroimaging studies have shown that classifiers did not elicit higher activation in the intraparietal sulcus (IPS), associated with representation of numerical magnitude, than tool nouns did. This study aimed to control the semantic attributes of classifiers and reexamine the underlying neural correlates. Participants performed a semantic distance comparison task in which they judged which one of the two items was semantically closer to the target...
November 8, 2017: Brain and Language
https://www.readbyqxmd.com/read/29125995/a-human-ips-cell-myogenic-differentiation-system-permitting-high-throughput-drug-screening
#10
Tomoya Uchimura, Jun Otomo, Masae Sato, Hidetoshi Sakurai
Muscular dystrophy is a disease characterized by progressive muscle weakness and degeneration. There are currently no available treatments for most muscular diseases, such as muscular dystrophy. Moreover, current therapeutics are focused on improving the quality of life of patients by relieving the symptoms or stress caused by the disease. Although the causative genes for many muscular diseases have been identified, the mechanisms underlying their pathogenesis remain unclear. Patient-derived induced pluripotent stem cells (iPSCs) have become a powerful tool for understanding the pathogenesis of intractable diseases, as well as for phenotype screening, which can serve as the basis for developing new drugs...
October 28, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29124794/effect-of-home-bleaching-on-the-translucency-of-cad-cam-systems
#11
Muhammet Karci, Necla Demir
PURPOSE: To evaluate the effect of a home bleaching agent (Opalescence PF) on the translucency of CAD/CAM ceramic systems. MATERIALS AND METHODS: The 28 sintered ceramic specimens (IPS Empress CAD and IPS e.max CAD; 15 mm long, 10 mm wide, 1 mm thick) were divided into two subgroups as control and bleaching groups (n = 7). Carbamide peroxide (CP), 16%, home bleaching agent was applied onto the surface of each specimen for 6 hours per day for 7 days. A spectrophotometer (VITA Easyshade Advance) was used to measure the CIE L(*) a(*) b(*) coordinates and the reflectance value (Y) of the specimens on white and black backgrounds...
November 10, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29118915/a-novel-culture-system-robustly-maintained-pluripotency-of-embryonic-stem-cells-and-accelerated-somatic-reprogramming-by-activating-wnt-signaling
#12
Shaojie Li, Xiao Lu, Haipeng He, Rong Cui, Xianxin Wang, Xiaoyun Wang, Xia Wu
Wnt signaling is intrinsic to embryonic stem cell self-renewal and mammalian development. However, the effects of wnts on ES cells self-renewal and iPS cells transduction was not clearly understood. In this study, L-Wnt3a cells that secreted activated Wnt3a protein into medium were used to produce Wnt3a condition medium (Wnt3a-CM) or feeder layer for ES cells cultivation and iPS cells transduction. The results showed that L-Wnt3a cells as feeder layer significantly promoted establishment of ES cell lines and generation of iPS cells...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29116664/unraveling-the-biology-of-bipolar-disorder-using-induced-pluripotent-stem-derived-neurons
#13
REVIEW
Nathaniel D Miller, John R Kelsoe
OBJECTIVES: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder...
November 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29116192/human-stem-cell-derived-retinal-epithelial-cells-activate-complement-via-collectin-11-in-response-to-stress
#14
Giorgia Fanelli, Anai Gonzalez-Cordero, Peter J Gardner, Qi Peng, Milan Fernando, Magdalena Kloc, Conrad A Farrar, Arifa Naeem, Peter Garred, Robin R Ali, Steven H Sacks
Age-related macular degeneration (AMD) is a major cause of blindness and is associated with complement dysregulation. The disease is a potential target for stem cell therapy but success is likely to be limited by the inflammatory response. We investigated the innate immune properties of human induced-pluripotent stem cell (iPSC)-derived RPE cells, particularly with regard to the complement pathway. We focused on collectin-11 (CL-11), a pattern recognition molecule that can trigger complement activation in renal epithelial tissue...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111375/a-novel-protocol-to-provide-a-suitable-cardiac-model-from-induced-pluripotent-stem-cells
#15
Mahsa Rasekhi, Masoud Soleimani, Behnaz Bakhshandeh, Majid Sadeghizadeh
Cumulative evidence has proven the safety, feasibility and efficacy of stem cell therapy for cardiomyocyte replacement in heart failure treatment. In contrast to embryonic stem cells, induced pluripotent stem cells (iPS cells) provide a route to the production of patient-specific stem cell lines with no ethical concerns. Recent studies have revealed that myogenic transcription factors activated the expression of conserved microRNAs (miRNAs), such as mir-1, that 'fine-tuned' the output of the transcriptional networks...
October 27, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29107134/restoration-of-severely-damaged-endodontically-treated-premolars-the-influence-of-the-endo-core-length-on-marginal-integrity-and-fatigue-resistance-of-lithium-disilicate-cad-cam-ceramic-endocrowns
#16
G T Rocca, R Daher, C M Saratti, R Sedlacek, T Suchy, A J Feilzer, I Krejci
OBJECTIVES: to explore fatigue limits of ceramic endocrowns for premolars. METHODS: Forty-eight devitalized premolars were cut at the CEJ. They were restored with standardized CAD-CAM lithium disilicate reinforced ceramic restorations (IPS e.max CAD, Ivoclar-Vivadent) and divided into four Groups (n=12): overlays (Group A, no endo-core, negative control), endocrowns with an endo-core of 2mm (Group B), 4mm (GroupC) and crowns with post and core (Group D, positive control)...
October 26, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29101088/effect-of-methylene-blue-induced-photodynamic-therapy-on-a-streptococcus-mutans-biofilm-model
#17
Mariana Alencar Nemezio, Sofia Sampaio de Souza Farias, Maria Cristina Borsatto, Carolina Patrícia Aires, Silmara Aparecida Milori Corona
BACKGROUND: Several studies have reported the use of antimicrobial photodynamic therapy (aPDT) to control biofilm but its efficacy depends on several factors, such as biofilm model used. This study aims to examine whether exposure to diode laser combined with methylene blue affects the bacterial viability and polysaccharide content in a Streptococcus mutans cariogenic biofilm model, which simulated 'feast-famine' episodes of exposure to sucrose that occur in the oral cavity. MATERIALS AND METHODS: S...
October 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29098596/interprofessional-simulation-training-to-promote-working-with-families-and-networks-in-mental-health-services
#18
Christopher Kowalski, Chris Attoe, Isabelle Ekdawi, Claire Parry, Sabrina Phillips, Sean Cross
OBJECTIVE: Working with the families and networks of patients with mental illness has significant benefits. There are, however, numerous barriers to this way of working, meaning that it is not universally privileged in mental healthcare services. This study evaluated the impact of an interprofessional simulation (IPS) course on working with families and networks on participants' confidence, attitudes, and perceived future clinical practice. METHODS: A one-day IPS course pairing high-fidelity scenarios with reflective debriefs was developed...
November 2, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/29097277/interfering-peptides-targeting-protein-protein-interactions-the-next-generation-of-drugs
#19
REVIEW
Heriberto Bruzzoni-Giovanelli, Valerie Alezra, Nicolas Wolff, Chang-Zhi Dong, Pierre Tuffery, Angelita Rebollo
Protein-protein interactions (PPIs) are well recognized as promising therapeutic targets. Consequently, interfering peptides (IPs) - natural or synthetic peptides capable of interfering with PPIs - are receiving increasing attention. Given their physicochemical characteristics, IPs seem better suited than small molecules to interfere with the large surfaces implicated in PPIs. Progress on peptide administration, stability, biodelivery and safety are also encouraging the interest in peptide drug development...
October 31, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29093090/inducible-microrna-3570-feedback-inhibits-the-rig-i-dependent-innate-immune-response-to-rhabdovirus-in-teleost-fish-by-targeting-mavs-ips-1
#20
Tianjun Xu, Qing Chu, Junxia Cui, Dekun Bi
Effectively recognizing invading viruses and subsequently inducing the innate antiviral immunity are essential for the host antiviral defense. Although these processes are closely regulated by the host to maintain the immune balance, viruses have evolved the abilities to downregulate or upregulate these processes for their survival. MicroRNAs (miRNAs) are a family of small non-coding RNAs that play vital roles in modulating host immune response. Accumulating evidence demonstrates that host miRNAs as mediators are involved in regulating viral replication and host anti-viral immunity in mammals...
November 1, 2017: Journal of Virology
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