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Feudjio Ndemanou Yolande, Bhattacharyya Sayantan, Ghosh Paramita, Sarkar Deblina, Mouokeu Raymond Simplice, Tume B Christopher, Murmu Nabendu
Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer-related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Sarah L Gardiner, Aster V E Harder, Yvonne J M Campman, Stella Trompet, Jacobijn Gussekloo, Martine J van Belzen, Merel W Boogaard, Raymund A C Roos, Iris E Jansen, Yolande A L Pijnenburg, Philip Scheltens, Wiesje M van der Flier, N Ahmad Aziz
Genomewide association studies (GWASs) have contributed greatly to unraveling the genetic basis of Alzheimer's disease (AD). However, a large amount of "missing heritability" remains. In this exploratory study, we investigated the effect of cytosine-adenine-guanine (CAG) repeats in polyglutamine disease-associated genes (PDAGs) on the risk of AD and its expression. In a cohort of 959 patients diagnosed with AD (Amsterdam Dementia cohort) and 4106 cognitively healthy participants (Leiden 85-plus Study and the Prospective Study of Pravastatin in the Elderly at Risk), we determined the CAG repeat sequences in ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, HTT, ATN1, and AR...
September 15, 2018: Neurobiology of Aging
Alon Amir, Jean-Francois Paré, Yoland Smith, Denis Paré
One of the main subcortical inputs to the basolateral nucleus of the amygdala (BL) originates from a group of dorsal thalamic nuclei located at or near the midline, mainly from the central medial (CMT) and paraventricular (PVT) nuclei. Although similarities between the responsiveness of BL, CMT, and PVT neurons to emotionally arousing stimuli suggest that these thalamic inputs exert a significant influence over BL activity, little is known about the synaptic relationships that mediate these effects. Thus, the present study used Phaseolus vulgaris-leucoagglutinin (PHAL) anterograde tracing and electron microscopy to shed light on the ultrastructural properties and synaptic targets of CMT and PVT axon terminals in the rat BL...
October 12, 2018: Journal of Comparative Neurology
Frédéric E Lecouvet, Daniela E Oprea-Lager, Yan Liu, Piet Ost, Luc Bidaut, Laurence Collette, Christophe M Deroose, Karolien Goffin, Ken Herrmann, Otto S Hoekstra, Gem Kramer, Yolande Lievens, Egesta Lopci, David Pasquier, Lars J Petersen, Jean-Noël Talbot, Helle Zacho, Bertrand Tombal, Nandita M deSouza
Oligometastatic disease represents a clinical and anatomical manifestation between localised and polymetastatic disease. In prostate cancer, as with other cancers, recognition of oligometastatic disease enables focal, metastasis-directed therapies. These therapies potentially shorten or postpone the use of systemic treatment and can delay further metastatic progression, thus increasing overall survival. Metastasis-directed therapies require imaging methods that definitively recognise oligometastatic disease to validate their efficacy and reliably monitor response, particularly so that morbidity associated with inappropriately treating disease subsequently recognised as polymetastatic can be avoided...
October 2018: Lancet Oncology
Melissa Petrakis, Yolande Stirling, Kate Higgins
BACKGROUND: Individuals experiencing severe and persistent mental illness report a desire to gain and sustain work. Individual Placement and Support (IPS) is an evidence-based approach to vocational rehabilitation to support competitive employment outcomes. AIM/OBJECTIVE: This study aimed to evaluate whether a joint-governance management partnership, between a clinical adult mental health and an employment service, could deliver a sustained IPS program in Australia...
October 9, 2018: Scandinavian Journal of Occupational Therapy
Wouter den Hollander, Irina Pulyakhina, Cindy Boer, Nils Bomer, Ruud van der Breggen, Wibowo Arindrarto, Rodrigo Couthino de Almeida, Nico Lakenberg, Thom Sentner, Jeroen F J Laros, Peter A C 't Hoen, Eline P E Slagboom, Rob G H H Nelissen, Joyce van Meurs, Yolande F M Ramos, Ingrid Meulenbelt
OBJECTIVES: Multiple osteoarthritis (OA) susceptibility single nucleotide polymorphisms (SNPs) mark imbalanced expression of positional genes in articular cartilage, reflected by unequally expressed alleles among heterozygotes (allelic imbalance, AI). Here, we explored the articular cartilage transcriptome from OA patients for AI events to identify putative disease driving genetic variation. METHODS: AI was assessed in N=42 preserved and N=5 lesioned OA cartilage samples (RAAK-study) for which RNA sequencing data was available...
October 9, 2018: Arthritis & Rheumatology
Tizza P Zomer, Jos N M Barendregt, Barend van Kooten, Thomas van Bemmel, Gijs W Landman, Babette C van Hees, Yolande M Vermeeren
OBJECTIVES: There is controversy whether non-specific symptoms can be related to previous Lyme borreliosis (LB). Positive serology can be considered a proxy for a previous or persistent infection with LB. We assessed non-specific symptoms and serology in patients suspected of LB referred to a Lyme centre. METHODS: Included were adult patients who visited a Lyme centre between 2008 and 2014. Before medical consultation, serum samples were taken and questionnaires on non-specific symptoms completed...
October 1, 2018: Clinical Microbiology and Infection
David Bergeron, Maria L Gorno-Tempini, Gil D Rabinovici, Miguel A Santos-Santos, William Seeley, Bruce L Miller, Yolande Pijnenburg, M Antoinette Keulen, Colin Groot, Bart N M van Berckel, Wiesje M van der Flier, Philip Scheltens, Jonathan D Rohrer, Jason D Warren, Jonathan M Schott, Nick C Fox, Raquel Sanchez-Valle, Oriol Grau-Rivera, Ellen Gelpi, Harro Seelaar, Janne M Papma, John C van Swieten, John R Hodges, Cristian E Leyton, Olivier Piguet, Emily J Rogalsky, Marsel M Mesulam, Lejla Koric, Kristensen Nora, Jérémie Pariente, Bradford Dickerson, Ian R Mackenzie, Ging-Yuek R Hsiung, Serge Belliard, David J Irwin, David A Wolk, Murray Grossman, Matthew Jones, Jennifer Harris, David Mann, Julie S Snowden, Patricio Chrem-Mendez, Ismael L Calandri, Alejandra A Amengual, Carole Miguet-Alfonsi, Eloi Magnin, Giuseppe Magnani, Roberto Santangelo, Vincent Deramecourt, Florence Pasquier, Niklas Mattsson, Christer Nilsson, Oskar Hansson, Julia Keith, Mario Masellis, Sandra E Black, Jordi A Matías-Guiu, María-Nieves Cabrera-Martin, Claire Paquet, Julien Dumuirger, Marc Teichmann, Marie Sarazin, Michel Bottlaender, Bruno Dubois, Christopher C Rowe, Victor L Villemagne, Rik Vandenberghe, Elias Granadillo, Edmond Teng, Mario Mendez, Philipp T Meyer, Lars Frings, Alberto Lleó, Rafael Blesa, Juan Fortea, Sang Won Seo, Janine Diehl-Schmid, Timo Grimmer, Kristian Steen Frederiksen, Pascual Sánchez-Juan, Gaël Chételat, Willemijn Jansen, Rémi W Bouchard, Laforce Robert, Pieter Jelle Visser, Rik Ossenkoppele
OBJECTIVE: To estimate the prevalence of amyloid-positivity, defined by PET/CSF biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n=443], non-fluent [nfvPPA, n=333], semantic [svPPA, n=401] and mixed/unclassifiable [PPA-M/U, n=74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n=600]), PET [n=366] and/or autopsy [n=378]) available...
September 26, 2018: Annals of Neurology
Ming Zhang, Raffaele Ferrari, Maria Carmela Tartaglia, Julia Keith, Ezequiel I Surace, Uri Wolf, Christine Sato, Mark Grinberg, Yan Liang, Zhengrui Xi, Kyle Dupont, Philip McGoldrick, Anna Weichert, Paul M McKeever, Raphael Schneider, Michael D McCorkindale, Claudia Manzoni, Rosa Rademakers, Neill R Graff-Radford, Dennis W Dickson, Joseph E Parisi, Bradley F Boeve, Ronald C Petersen, Bruce L Miller, William W Seeley, John C van Swieten, Jeroen van Rooij, Yolande Pijnenburg, Julie van der Zee, Christine Van Broeckhoven, Isabelle Le Ber, Vivianna Van Deerlin, EunRan Suh, Jonathan D Rohrer, Simon Mead, Caroline Graff, Linn Öijerstedt, Stuart Pickering-Brown, Sara Rollinson, Giacomina Rossi, Fabrizio Tagliavini, William S Brooks, Carol Dobson-Stone, Glenda M Halliday, John R Hodges, Olivier Piguet, Giuliano Binetti, Luisa Benussi, Roberta Ghidoni, Benedetta Nacmias, Sandro Sorbi, Amalia C Bruni, Daniela Galimberti, Elio Scarpini, Innocenzo Rainero, Elisa Rubino, Jordi Clarimon, Alberto Lleó, Agustin Ruiz, Isabel Hernández, Pau Pastor, Monica Diez-Fairen, Barbara Borroni, Florence Pasquier, Vincent Deramecourt, Thibaud Lebouvier, Robert Perneczky, Janine Diehl-Schmid, Jordan Grafman, Edward D Huey, Richard Mayeux, Michael A Nalls, Dena Hernandez, Andrew Singleton, Parastoo Momeni, Zhen Zeng, John Hardy, Janice Robertson, Lorne Zinman, Ekaterina Rogaeva
The G4C2-repeat expansion in C9orf72 is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. The high phenotypic heterogeneity of C9orf72 patients includes a wide range in age of onset, modifiers of which are largely unknown. Age of onset could be influenced by environmental and genetic factors both of which may trigger DNA methylation changes at CpG sites. We tested the hypothesis that age of onset in C9orf72 patients is associated with some common single nucleotide polymorphisms causing a gain or loss of CpG sites and thus resulting in DNA methylation alterations...
October 1, 2018: Brain: a Journal of Neurology
Lize C Jiskoot, Martina Bocchetta, Jennifer M Nicholas, David M Cash, David Thomas, Marc Modat, Sebastien Ourselin, Serge A R B Rombouts, Elise G P Dopper, Lieke H Meeter, Jessica L Panman, Rick van Minkelen, Emma L van der Ende, Laura Donker Kaat, Yolande A L Pijnenburg, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Janne M Papma, John C van Swieten, Jonathan D Rohrer
Objective: We aimed to investigate mutation-specific white matter (WM) integrity changes in presymptomatic and symptomatic mutation carriers of the C9orf72 , MAPT , and GRN mutations by use of diffusion-weighted imaging within the Genetic Frontotemporal dementia Initiative (GENFI) study. Methods: One hundred and forty mutation carriers (54 C9orf72 , 30 MAPT , 56 GRN ), 104 presymptomatic and 36 symptomatic, and 115 noncarriers underwent 3T diffusion tensor imaging...
September 2018: Annals of Clinical and Translational Neurology
Samuel Wanji, Winston Patrick Chounna Ndongmo, Fanny Fri Fombad, Jonas Arnaud Kengne-Ouafo, Abdel Jelil Njouendou, Yolande Flore Longang Tchounkeu, Benjamin Koudou, Moses Bockarie, Grace Fobi, Jean Baptiste Roungou, Peter A Enyong
BACKGROUND: Loiasis is a filarial infection endemic in the rainforest zone of west and central Africa particularly in Cameroon, Gabon, Republic of Congo, and Democratic Republic of the Congo. Repeated treatments with ivermectin have been delivered using the annual community directed treatment with ivermectin (CDTI) approach for several years to control onchocerciasis in some Loa loa-Onchocerca volvulus co-endemic areas. The impact of CDTI on loiasis parasitological indicators is not known...
September 2018: PLoS Neglected Tropical Diseases
Barbara Vanderstraeten, Bruno Goddeeris, Katrien Vandecasteele, Marc van Eijkeren, Carlos De Wagter, Yolande Lievens
PURPOSE: Automated planning aims to speed up treatment planning and improve plan quality. We compared manual planning with automated planning for lung stereotactic body radiation therapy based on dose-volume histogram statistics and clinical preference. METHODS AND MATERIALS: Manual and automated intensity modulated radiation therapy plans were generated for 56 patients by use of software developed in-house and Pinnacle 9.10 Auto-Planning, respectively. Optimization times were measured in 10 patients, and the impact of the automated plan (AP) on the total treatment cost was estimated...
October 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Valérie Fonteyne, Elke Rammant, Piet Ost, Yolande Lievens, Bart De Troyer, Sylvie Rottey, Gert De Meerleer, Daan De Maeseneer, Dirk De Ridder, Karel Decaestecker
INTRODUCTION: There is a gap between optimal and actual use of radiotherapy (RT) in muscle-invasive bladder cancer (MIBC). We investigated the opinions of radiation-oncologists, urologists, and medical oncologists on use of RT in different cases. Barriers and facilitators for applying guidelines were examined. MATERIAL AND METHODS: A web-based survey was developed at Ghent University Hospital and conducted from November 18, 2016 to July 17, 2017. The place of primary, adjuvant, and palliative RT was evaluated...
August 11, 2018: Clinical Genitourinary Cancer
Everard G B Vijverberg, Flora Gossink, Welmoed Krudop, Annemiek Dols, Yolande A L Pijnenburg
Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disease, the symptoms of which are changes in character, behavioural changes and socio-cognitive changes occurring predominantly at an age between 40 and 70 years. Frontotemporal atrophy is apparent on diagnostic imaging in 70% of patients with bvFTD; a diagnostic dilemma arises if this is not clearly obvious. Validated questionnaires for stereotypical behaviour, depressive symptoms and apathy, and neuropsychological examination can be very helpful in differentiating between bvFTD and psychiatric and other neurological conditions...
August 3, 2018: Nederlands Tijdschrift Voor Geneeskunde
Charlotte Schutz, Angharad G Davis, Bianca Sossen, Rachel P-J Lai, Mpiko Ntsekhe, Yolande Xr Harley, Robert J Wilkinson
Inflammation, or the prolonged resolution of inflammation, contributes to death from tuberculosis. Interest in inflammatory mechanisms and the prospect of beneficial immune modulation as an adjunct to antibacterial therapy has revived and the concept of host directed therapies has been advanced. Such renewed attention has however, overlooked the experience of such therapy with corticosteroids. Areas covered: The authors conducted literature searches and evaluated randomized clinical trials, systematic reviews and current guidelines and summarize these findings...
October 2018: Expert Review of Respiratory Medicine
Linda Gore Martin, Yolande Hanssens, Vibhu Paudyal
No abstract text is available yet for this article.
August 2018: International Journal of Clinical Pharmacy
Yolande Bertin, Audrey Segura, Gregory Jubelin, Lysiane Dunière, Alexandra Durand, Evelyne Forano
The gastrointestinal tract (GIT) of healthy cattle is the main reservoir of enterohaemorrhagic Escherichia coli (EHEC). Therefore, it is crucial to better understand the physiology of EHEC in the bovine GIT. In this study, we demonstrate that aspartate present in bovine small intestine content (BSIC), was exhausted after incubation of the reference EHEC strain EDL933 but was poorly assimilated by the endogenous microbiota. Furthermore, the bovine commensal E. coli strain BG1 appeared less efficient than EDL933 in aspartate assimilation suggesting a competitive ability of EHEC to assimilate this amino acid...
August 15, 2018: Environmental Microbiology
Lianne M Reus, Everard Gb Vijverberg, Betty M Tijms, Mara Ten Kate, Flora Gossink, Welmoed A Krudop, Marta Del Campo, Charlotte E Teunissen, Frederik Barkhof, Wiesje M van der Flier, Pieter Jelle Visser, Annemiek Dols, Yolande Al Pijnenburg
Behavioural variant frontotemporal dementia (bvFTD) is characterized by behavioural and social cognitive disturbances, while various psychiatric and neurodegenerative disorders may have similar clinical symptoms. Since neurodegenerative disorders are eventually progressive, whereas primary psychiatric disorders are not, this study aimed to investigate whether the change in clinical symptoms over time differed between groups and which biomarkers predicted rate of decline. Disease trajectories (median follow-up = 3 years) of frontal and stereotyped behaviour, general and frontal cognitive functioning, and social cognition were examined in bvFTD (n = 34), other neurodegenerative (n = 28) and primary psychiatric disorders (n = 43), all presenting with late-onset frontal lobe syndrome (45-75 years), using linear mixed models...
September 2018: Journal of Psychiatric Research
Yolande Appelman
No abstract text is available yet for this article.
August 3, 2018: EuroIntervention
Florian Jacques, Sonia Rippa, Yolande Perrin
L-carnitine is present in all living kingdoms where it acts in diverse physiological processes. It is involved in lipid metabolism in animals and yeasts, notably as an essential cofactor of fatty acid intracellular trafficking. Its physiological significance is poorly understood in plants, but L-carnitine may be linked to fatty acid metabolism among other roles. Indeed, carnitine transferases activities and acylcarnitines are measured in plant tissues. Current knowledge of fatty acid trafficking in plants rules out acylcarnitines as intermediates of the peroxisomal and mitochondrial fatty acid metabolism, unlike in animals and yeasts...
September 2018: Plant Science: An International Journal of Experimental Plant Biology
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