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Yolande Bertin, Audrey Segura, Gregory Jubelin, Lysiane Dunière, Alexandra Durand, Evelyne Forano
The gastrointestinal tract (GIT) of healthy cattle is the main reservoir of enterohaemorrhagic Escherichia coli (EHEC). Therefore, it is crucial to better understand the physiology of EHEC in the bovine GIT. In this study, we demonstrate that aspartate present in bovine small intestine content (BSIC), was exhausted after incubation of the reference EHEC strain EDL933 but was poorly assimilated by the endogenous microbiota. Furthermore, the bovine commensal E. coli strain BG1 appeared less efficient than EDL933 in aspartate assimilation suggesting a competitive ability of EHEC to assimilate this amino acid...
August 15, 2018: Environmental Microbiology
Lianne M Reus, Everard Gb Vijverberg, Betty M Tijms, Mara Ten Kate, Flora Gossink, Welmoed A Krudop, Marta Del Campo, Charlotte E Teunissen, Frederik Barkhof, Wiesje M van der Flier, Pieter Jelle Visser, Annemiek Dols, Yolande Al Pijnenburg
Behavioural variant frontotemporal dementia (bvFTD) is characterized by behavioural and social cognitive disturbances, while various psychiatric and neurodegenerative disorders may have similar clinical symptoms. Since neurodegenerative disorders are eventually progressive, whereas primary psychiatric disorders are not, this study aimed to investigate whether the change in clinical symptoms over time differed between groups and which biomarkers predicted rate of decline. Disease trajectories (median follow-up = 3 years) of frontal and stereotyped behaviour, general and frontal cognitive functioning, and social cognition were examined in bvFTD (n = 34), other neurodegenerative (n = 28) and primary psychiatric disorders (n = 43), all presenting with late-onset frontal lobe syndrome (45-75 years), using linear mixed models...
August 1, 2018: Journal of Psychiatric Research
Yolande Appelman
No abstract text is available yet for this article.
August 3, 2018: EuroIntervention
Florian Jacques, Sonia Rippa, Yolande Perrin
L-carnitine is present in all living kingdoms where it acts in diverse physiological processes. It is involved in lipid metabolism in animals and yeasts, notably as an essential cofactor of fatty acid intracellular trafficking. Its physiological significance is poorly understood in plants, but L-carnitine may be linked to fatty acid metabolism among other roles. Indeed, carnitine transferases activities and acylcarnitines are measured in plant tissues. Current knowledge of fatty acid trafficking in plants rules out acylcarnitines as intermediates of the peroxisomal and mitochondrial fatty acid metabolism, unlike in animals and yeasts...
September 2018: Plant Science: An International Journal of Experimental Plant Biology
Flora Gossink, Yolande Pijnenburg, Philip Scheltens, Aafke Pera, Rikie Kleverwal, Nicole Korten, Max Stek, Rose-Marie Dröes, Annemiek Dols
AIM: Caregivers of dementia patients experience high levels of burden; this is especially true of caregivers of dementia patients with behavioural problems. As intervention studies for these caregivers are still lacking, we conducted an explorative pilot study into the efficacy of a support programme. METHODS: Participants were caregivers of dementia patients affected by apathy, disinhibition, and/or stereotypical behaviour. All patients had a Frontal Behavioural Inventory score of 11 or higher...
July 31, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Mareike K Thompson, Philip Poortmans, Anthony J Chalmers, Corinne Faivre-Finn, Emma Hall, Robert A Huddart, Yolande Lievens, David Sebag-Montefiore, Charlotte E Coles
As we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy (RT) research. Large-scale international RT clinical trials have been fundamental in driving evidence-based change and have served to improve cancer management and to reduce side effects. Radiation therapy trials have also improved practice by increasing quality assurance and consistency in treatment protocols across multiple centres. This review summarises some of the key RT practice-changing clinical trials over the last two decades, in four common cancer sites for which RT is a crucial component of curative treatment: breast, lung, urological and lower gastro-intestinal cancer...
July 31, 2018: British Journal of Cancer
Johannes A Langendijk, Roberto Orecchia, Karin Haustermans, Daniel Zips, Jacques Balosso, Denis Lacombe, Yolande Lievens, Damien C Weber, Cai Grau, Esther G C Troost
The overarching aim of work package 1 of the European Proton Therapy Network (EPTN) is to create a firm basis for evidence-based particle therapy at the European level. To achieve this, this work package will set up a worldwide unique prospective data registration programme for nine different tumour sites. Such programme will provide more insights into the current practice across all European particle therapy centres and into the results of particle therapy with regard to radiation-induced toxicity and efficacy in terms of local control and survival...
July 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Gilles Vergnaud, Yolande Hauck, David Christiany, Brendan Daoud, Christine Pourcel, Isabelle Jacques, Axel Cloeckaert, Michel S Zygmunt
Previous studies have shown the usefulness of MLVA16 as a rapid molecular identification and classification method for Brucella species and biovars including recently described novel Brucella species from wildlife. Most studies were conducted on a limited number of strains from limited geographic/host origins. The objective of this study was to assess genetic diversity of Brucella spp. by MLVA16 on a larger scale. Thus, 1404 animal or human isolates collected from all parts of the world over a period of 32 years (1974-2006) were investigated...
2018: Frontiers in Microbiology
Jan Philipp Ramspott, Fériel Bekkat, Lloyd Bod, Maryline Favier, Benoit Terris, Anne Salomon, Lounes Djerroudi, Kurt S Zaenker, Yolande Richard, Valérie Molinier-Frenkel, Flavia Castellano, Marie-Françoise Avril, Armelle Prévost-Blondel
Several studies have emphasized the importance of immune composition of the melanoma microenvironment for the clinical outcome. The contribution of IL4-induced gene 1 (IL4I1), a phenylalanine oxidase with immunoregulatory functions, has not been yet explored. Here we studied a primary cutaneous melanoma series from stage I-III patients in order to investigate the association between in situ IL4I1 expression and clinical parameters or tumor infiltrating T-cell subsets. IL4I1 was detected in 87% of tumors and was mainly expressed by tumor-associated macrophages and very rare FoxP3+ regulatory T cells (Tregs)...
July 23, 2018: Journal of Investigative Dermatology
Hanneke Frederica Maria Rhodius-Meester, Betty M Tijms, Afina W Lemstra, Niels D Prins, Yolande A L Pijnenburg, Femke Bouwman, Philip Scheltens, Wiesje M van der Flier
No abstract text is available yet for this article.
July 25, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Jolien Schaeverbeke, Silvy Gabel, Karen Meersmans, Rose Bruffaerts, Antonietta Gabriella Liuzzi, Charlotte Evenepoel, Eva Dries, Karen Van Bouwel, Anne Sieben, Yolande Pijnenburg, Ronald Peeters, Guy Bormans, Koen Van Laere, Michel Koole, Patrick Dupont, Rik Vandenberghe
BACKGROUND: A subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a 'mixed variant' phenotype. This phenotype is rare and currently not fully characterized. The aim of this study was twofold: to assess the prevalence and nature of single-word comprehension problems in the nonfluent variant and to study multimodal imaging characteristics of atrophy, tau, and amyloid burden associated with this mixed phenotype...
July 18, 2018: Alzheimer's Research & Therapy
Gul Yalcin-Cakmakli, Samuel J Rose, Rosa M Villalba, Lagena Williams, Hyder A Jinnah, Ellen J Hess, Yoland Smith
Striatal cholinergic dysfunction is a common phenotype associated with various forms of dystonia in which anti-cholinergic drugs have some therapeutic benefits. However, the underlying substrate of striatal cholinergic defects in dystonia remain poorly understood. In this study, we used a recently developed knock-in mouse model of dopamine-responsive dystonia (DRD) with strong symptomatic responses to anti-cholinergic drugs, to assess changes in the prevalence and morphology of striatal cholinergic interneurons (ChIs) in a model of generalized dystonia...
2018: Frontiers in Systems Neuroscience
Nienke M E Scheltens, Kars van der Weijden, Sofie M Adriaanse, Danielle van Assema, Priscilla P Oomen, Welmoed A Krudop, Adriaan A Lammertsma, Frederik Barkhof, Teddy Koene, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Yolande A L Pijnenburg, Maqsood Yaqub, Rik Ossenkoppele, Bart N M van Berckel
When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the behavioural variant of frontotemporal dementia (bvFTD), distribution of cerebral glucose metabolism as measured using [18 F]‑2‑fluoro‑2‑deoxy‑d‑glucose positron emission tomography ([18 F]FDG-PET) may be helpful. One important clue for differentiation is the presence of hypometabolism in the posterior cingulate cortex (PCC), usually associated with AD. PCC hypometabolism however, could also be present in bvFTD...
2018: NeuroImage: Clinical
Anthony M Brade, Frederik Wenz, Friederike Koppe, Yolande Lievens, Belen San Antonio, Neill A Iscoe, Anwar Hossain, Nadia Chouaki, Suresh Senan
PURPOSE: Chemoradiation therapy trials of different tumors, including lung cancer, have shown a correlation between protocol deviations and adverse outcomes. Radiation therapy quality assurance (RTQA) was mandated for all patients treated in the PROCLAIM trial evaluating 2 different chemoradiation therapy regimens. The RTQA results were evaluated from the PROCLAIM study, and the impact of irradiation deviations on efficacy outcomes was investigated. METHODS AND MATERIALS: The study was conducted from 2008 to 2014...
July 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Ajay Aggarwal, Grant Lewison, Danielle Rodin, Anthony Zietman, Richard Sullivan, Yolande Lievens
Radiation therapy is a core modality of cancer treatment; however, concerns have been expressed regarding its underutilization and its lack of prioritization as a research domain relative to other cancer treatment modalities, despite its rapid technical evolution. It is therefore important to understand, from a public policy perspective, the evolution of global radiation therapy research, to identify strengths, weaknesses, and opportunities. This study used a bibliometric approach to undertake a quantitative analysis of global radiation therapy research published between 2001 and 2015 and available in the Web of Science (Wos) database, with particular focus on the 25 leading research-active countries...
July 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Jolien Schaeverbeke, Charlotte Evenepoel, Lieven Declercq, Silvy Gabel, Karen Meersmans, Rose Bruffaerts, Kate Adamczuk, Eva Dries, Karen Van Bouwel, Anne Sieben, Yolande Pijnenburg, Ronald Peeters, Guy Bormans, Koen Van Laere, Michel Koole, Patrick Dupont, Rik Vandenberghe
PURPOSE: To assess the binding of the PET tracer [18 F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology. METHODS: The study included 20 PPA patients consecutively recruited through a memory clinic (12 NFV, 5 SV, 3 LV), and 20 healthy controls...
June 26, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Benjamin Gollasch, Oskar Wischnewski, Birgit Rudolph, Yoland-Marie Anistan, Friedrich C Luft, Maik Gollasch
We present a 42-year-old man with a BMI of 32, who was referred because of proteinuria and decreased renal function. We were impressed by his markedly muscular physique. A renal biopsy was performed, which showed focal segmental glomerular sclerosis (FSGS). Is this patient merely an obese person with FSGS or is something else going on here? We performed extensive clinical and laboratory examinations, genetic testing, and anthropometric data monitoring over time. We transferred our methodology for routine FSGS mutation screening (Sanger sequencing) to the Ion Torrent PGM platform with a new custom-targeted NGS gene panel (Ion Ampliseq FSGS panel) and tested the performance of the system in two cohorts of patients with FSGS...
May 2018: Case Reports in Nephrology and Dialysis
David A Pistenmaa, Manjit Dosanjh, Ugo Amaldi, David Jaffray, Eduardo Zubizarreta, Katherine Holt, Yolande Lievens, Yakov Pipman, C Norman Coleman
No abstract text is available yet for this article.
June 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Chris Monten, Liv Veldeman, Katrien Vandecasteele, Luiza Oltéanu, Werner De Gersem, Tom Vercauteren, Thomas Mulliez, Rudy Van Den Broecke, Herman Depypere, Wilfried De Neve, Yolande Lievens
INTRODUCTION: In view of the limited incremental benefit between whole breast irradiation (WBI), accelerated partial breast irradiation (APBI) and omission of radiotherapy in favorable early-stage breast cancer (ESBC), APBI can only be justified if it combines adequate target coverage with the lowest achievable toxicity. Interobserver exercises demonstrated the difficulty of precise target delineation, especially in prone position; information on accuracy is even scarcer. We tested the impact of inserting an additional indicator clip, marking the depth of the tumor in the breast, and the added value of a preoperative CT in treatment position on precision and accuracy...
June 6, 2018: Acta Oncologica
Dorien M Kimenai, Emma B N J Janssen, Kai M Eggers, Bertil Lindahl, Hester M den Ruijter, Otto Bekers, Yolande Appelman, Steven J R Meex
BACKGROUND: The overall clinical decision limits of high-sensitivity cardiac troponin I (hs-cTnI; 26 ng/L) and T (hs-cTnT; 14 ng/L) may contribute to underdiagnosis of acute myocardial infarction in women. We performed a systematic review to investigate sex-specific and overall 99th percentiles of hs-cTnI and hs-cTnT derived from healthy reference populations. CONTENT: We searched in PubMed and EMBASE for original studies, and by screening reference lists. Reference populations designed to establish 99th percentiles of hs-cTnI (Abbott) and/or hs-cTnT (Roche), published between January 2009 and October 2017, were included...
July 2018: Clinical Chemistry
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