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https://www.readbyqxmd.com/read/30302777/the-role-of-the-unfolded-protein-response-in-cancer-progression-from-oncogenesis-to-chemoresistance
#1
REVIEW
Emma Madden, Susan E Logue, Sandra J Healy, Serge Manie, Afshin Samali
Tumour cells endure both oncogenic and environmental stresses during cancer progression. Transformed cells must meet increased demands for protein and lipid production needed for rapid proliferation and must adapt to exist in an oxygen and nutrient deprived environment. To overcome such challenges, cancer cells exploit intrinsic adaptive mechanisms such as the unfolded protein response (UPR). The UPR is a pro-survival mechanism triggered by accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), a condition referred to as ER stress...
October 10, 2018: Biology of the Cell
https://www.readbyqxmd.com/read/30199454/changes-in-parameters-of-oxidative-stress-immunity-and-behavior-in-endurance-athletes-during-a-preparation-period-in-winter
#2
Danica Michalickova, Rajna Minic, Jelena Kotur-Stevuljevic, Marija Andjelkovic, Nenad Dikic, Marija Kostic-Vucicevic, Ondrej Slanar, Brizita Djordjevic
Michalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, M, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res XX(X): 000-000, 2018-The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletes: V[Combining Dot Above]O2max: 68 ± 11 ml·kg·min, age: 24 ± 2.5 years, and training loads: 128 ± 21 metabolic equivalents-h·wk during a 3-month preparation period in winter (January-March)...
September 7, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/30152131/solving-donor-organ-shortage-with-insights-from-freeze-tolerance-in-nature-activating-endogenous-antioxidant-systems-with-non-coding-rna-to-precondition-donor-organs
#3
REVIEW
Bryan E Luu, Kenneth B Storey
The North American wood frog, Rana sylvatica, endures seasonal whole-body freezing during the winter and thawing during the spring without sustaining any apparent damage from ice or oxidative stress. Strategies from these frogs may solve the shortage of human donor organs, which is a multidisciplinary problem that can be alleviated by eliminating geographical boundaries. Rana sylvatica deploys an array of molecular and physiological responses, such as glucose production and microRNA regulation, to help it survive the cold...
August 27, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/30144941/epigenetic-environmental-memories-in-plants-establishment-maintenance-and-reprogramming
#4
REVIEW
Yuehui He, Zicong Li
Plants are immobile and must respond to or endure fluctuating surroundings and diverse environmental challenges. Environmental inputs often induce chromatin modifications at various responsive genes and consequent changes in their expression. Environment-induced chromatin marks at certain loci are transmittable through cell divisions after relief from the original external signals, leading to acquired 'memorization' of environmental experiences in plants, namely epigenetic environmental memories, which enable plants to adapt to environmental changes or to perform better when events recur...
August 22, 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/30124915/psychiatric-aeromedical-evacuations-of-deployed-active-duty-u-s-military-personnel-during-operations-enduring-freedom-iraqi-freedom-and-new-dawn
#5
Alan L Peterson, Willie J Hale, Monty T Baker, Jeffrey A Cigrang, Brian A Moore, Casey L Straud, Susan F Dukes, Stacey Young-McCaughan, Cubby L Gardner, Deborah Arant-Daigle, Mary Jo Pugh, Iman Williams Christians, Jim Mintz
Introduction: The primary objective of this study was to describe the demographic, clinical, and attrition characteristics of active duty U.S. military service members who were aeromedically evacuated from Iraq and Afghanistan theaters with a psychiatric condition as the primary diagnosis. The study links the U.S. Transportation Command Regulating and Command and Control Evacuation System (TRAC2ES) data with the Defense Manpower Data Center (DMDC) to conduct an examination of the long-term occupational impact of psychiatric aeromedical evacuations on military separations and discharges...
August 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/30056413/muscle-dysfunction-is-associated-with-poorer-health-related-quality-of-life-in-adults-with-sickle-cell-anaemia
#6
Carlos Eduardo Amaral Gonçalves, Priscila Oliveira Silva, Mauricio Santos Soares, Priscila Santos Bunn, Carla Martins Araujo Lima, Agnaldo José Lopes
BACKGROUND: It is known that episodes of microvascular obstruction and oxidative stress in sickle cell anaemia (SCA) can damage muscle tissue. As a consequence, deterioration in muscle function may potentially contribute to poor health-related quality of life (HRQoL) in subjects with SCA, particularly those who do not use long-term treatment. OBJECTIVES: To evaluate muscle function in adults with SCA, to study the correlations between muscle function and HRQoL and to analyse the impact of hydroxyurea treatment...
July 18, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/30028332/a-partition-type-tubular-scaffold-loaded-with-pdgf-releasing-microspheres-for-spinal-cord-repair-facilitates-the-directional-migration-and-growth-of-cells
#7
Xue Chen, Mei-Ling Xu, Cheng-Niu Wang, Lu-Zhong Zhang, Ya-Hong Zhao, Chang-Lai Zhu, Ying Chen, Jian Wu, Yu-Min Yang, Xiao-Dong Wang
The best tissue-engineered spinal cord grafts not only match the structural characteristics of the spinal cord but also allow the seed cells to grow and function in situ. Platelet-derived growth factor (PDGF) has been shown to promote the migration of bone marrow stromal cells; however, cytokines need to be released at a steady rate to maintain a stable concentration in vivo. Therefore, new methods are needed to maintain an optimal concentration of cytokines over an extended period of time to effectively promote seed cell localization, proliferation and differentiation...
July 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29990872/plumbagin-ameliorates-hepatic-ischemia-reperfusion-injury-in-rats-role-of-high-mobility-group-box-1-in-inflammation-oxidative-stress-and-apoptosis
#8
Aya M Zaki, Dalia M El-Tanbouly, Rania M Abdelsalam, Hala F Zaki
Ischemia-reperfusion (I/R) injury is a pathological process which magnifies with the ensuing inflammatory response and endures with the increase of oxidants especially during reperfusion. The present study was conducted to assess the possible modulatory effects of plumbagin, the active constituent extracted from the roots of traditional medicinal plant Plumbago zeylanica L., on the dire role of high mobility group box 1 (HMGB1) as well as the associated inflammation, oxidative stress and apoptotic cell death following hepatic I/R...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29971916/highly-stable-battery-pack-via-insulated-reinforced-buckling-enabled-interconnect-array
#9
Lu Yin, Joon Kyo Seo, Jonas Kurniawan, Rajan Kumar, Jian Lv, Lingye Xie, Xinyu Liu, Sheng Xu, Ying S Meng, Joseph Wang
This work describes a flexible and stretchable battery pack configuration that exhibits highly stable performance under large deformation up to 100% biaxial stretching. Using stress-enduring printable inks and serpentine interconnects, the new screen-printing route offers an attractive solution for converting rigid battery units into a flexible, stretchable energy storage device. Coin-cell lithium ion batteries are thus assembled onto the island regions of a screen-printed, buckling-enabled, polymer-reinforced interconnect "island-bridge" array...
July 3, 2018: Small
https://www.readbyqxmd.com/read/29951989/stress-induced-antioxidant-defense-and-protein-chaperone-response-in-the-freeze-tolerant-wood-frog-rana-sylvatica
#10
Cheng-Wei Wu, Shannon N Tessier, Kenneth B Storey
Freeze tolerance is an adaptive response utilized by the wood frog Rana sylvatica to endure the sub-zero temperatures of winter. Survival of whole body freezing requires wood frogs to trigger cryoprotective mechanisms to deal with potential injuries associated with conversion of 65-70% of total body water into ice, including multiple consequences of ice formation such as cessation of blood flow and cell dehydration caused by water loss into ice masses. To understand how wood frogs defend against these stressors, we measured the expression of proteins known to be involved in the antioxidant defense and protein chaperone stress responses in brain and heart of wood frogs comparing freezing, anoxia, and dehydration stress...
June 27, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29934212/the-impact-of-sport-related-stressors-on-immunity-and-illness-risk-in-team-sport-athletes
#11
REVIEW
Lauren C Keaney, Andrew E Kilding, Fabrice Merien, Deborah K Dulson
OBJECTIVES: Elite team-sport athletes are frequently exposed to stressors that have the potential to depress immunity and increase infection risk. Therefore, the purpose of this review is to describe how team-sport stressors impact upon immune responses, along with exploring whether alterations in these markers have the potential to predict upper respiratory tract illness symptoms. DESIGN: Narrative review. METHODS: Salivary secretory immunoglobulin A (SIgA) and T-cell markers have been shown to predict infection risk in individual endurance athletes...
June 19, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29907081/genome-wide-surveys-reveal-polarity-and-cytoskeletal-regulators-mediate-lkb1-associated-germline-stem-cell-quiescence
#12
Pratik Kadekar, Rita Chaouni, Emily Clark, Anna Kazanets, Richard Roy
BACKGROUND: Caenorhabditis elegans can endure long periods of environmental stress by altering their development to execute a quiescent state called "dauer". Previous work has implicated LKB1 - the causative gene in the autosomal dominant, cancer pre-disposing disease called Peutz-Jeghers Syndrome (PJS), and its downstream target AMPK, in the establishment of germline stem cell (GSC) quiescence during the dauer stage. Loss of function mutations in both LKB1/par-4 and AMPK/aak(0) result in untimely GSC proliferation during the onset of the dauer stage, although the molecular mechanism through which these factors regulate quiescence remains unclear...
June 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29726683/deciphering-the-mechanical-properties-of-type-iii-secretion-system-espa-protein-by-single-molecule-force-spectroscopy
#13
Hila Nadler, Lihi Shaulov, Yossi Blitsman, Moran Mordechai, Jürgen Jopp, Neta Sal-Man, Ronen Berkovich
Bacterial pathogens inject virulence factors into host cells during bacterial infections using type III secretion systems. In enteropathogenic Escherichia coli, this system contains an external filament, formed by a self-oligomerizing protein called E. coli secreted protein A (EspA). The EspA filament penetrates the thick viscous mucus layer to facilitate the attachment of the bacteria to the gut-epithelium. To do that, the EspA filament requires noteworthy mechanical endurance considering the mechanical shear stresses found within the intestinal tract...
May 29, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29721206/stress-and-stem-cells-adult-muse-cells-tolerate-extensive-genotoxic-stimuli-better-than-mesenchymal-stromal-cells
#14
Nicola Alessio, Tiziana Squillaro, Servet Özcan, Giovanni Di Bernardo, Massimo Venditti, Mariarosa Melone, Gianfranco Peluso, Umberto Galderisi
Mesenchymal stromal cells (MSCs) are not a homogenous population but comprehend several cell types, such as stem cells, progenitor cells, fibroblasts, and other types of cells. Among these is a population of pluripotent stem cells, which represent around 1-3% of MSCs. These cells, named multilineage-differentiating stress enduring (Muse) cells, are stress-tolerant cells. Stem cells may undergo several rounds of intrinsic and extrinsic stresses due to their long life and must have a robust and effective DNA damage checkpoint and DNA repair mechanism, which, following a genotoxic episode, promote the complete recovery of cells rather than triggering senescence and/or apoptosis...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29707971/human-multilineage-differentiating-stress-enduring-cells-exert-pleiotropic-effects-to-ameliorate-acute-lung-ischemia-reperfusion-injury-in-a-rat-model
#15
Hiroshi Yabuki, Shohei Wakao, Yoshihiro Kushida, Mari Dezawa, Yoshinori Okada
Posttransplantation lung ischemia-reperfusion (IR) injuries affect both patient survival and graft function. In this study, we evaluated the protective effects of infused human multilineage-differentiating stress-enduring (Muse) cells, a novel, easily harvested type of nontumorigenic endogenous reparative stem cell, against acute IR lung injury in a rat model. After a 2-h warm IR injury induction in a left rat lung, human Muse cells, human mesenchymal stem cells (MSCs), and vehicle were injected via the left pulmonary artery after reperfusion...
June 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29669110/chronic-occupational-exposure-endured-by-tobacco-farmers-from-brazil-and-association-with-dna-damage
#16
Vívian F Silva Kahl, Varinderpal Singh Dhillon, Daniel Simon, Fernanda Rabaioli da Silva, Mirian Salvador, Cátia Dos Santos Branco, Mónica Cappetta, Wilner Martínez-López, Flávia V Thiesen, Johnny F Dias, Claudia Telles de Souza, Michael Fenech, Juliana da Silva
Tobacco farming is an important economic income in Brazil, although it has been challenged as regard the occupational exposure to both pesticides and nicotine endured by farmers. Chronic occupational exposure to complex mixtures can lead to health hazardous. We examined genomic instability and epigenetic changes in tobacco farmers occupationally exposed to pesticide mixtures and nicotine at tobacco fields. DNA damage was assessed by alkaline comet assay in blood cells. Genomic DNA was isolated, and telomere length was measured using quantitative polymerase chain reaction assay...
April 13, 2018: Mutagenesis
https://www.readbyqxmd.com/read/29559260/intravenously-injected-human-multilineage-differentiating-stress-enduring-cells-selectively-engraft-into-mouse-aortic-aneurysms-and-attenuate-dilatation-by-differentiating-into-multiple-cell-types
#17
Katsuhiro Hosoyama, Shohei Wakao, Yoshihiro Kushida, Fumitaka Ogura, Kay Maeda, Osamu Adachi, Shunsuke Kawamoto, Mari Dezawa, Yoshikatsu Saiki
OBJECTIVES: Aortic aneurysms result from the degradation of multiple components represented by endothelial cells, vascular smooth muscle cells, and elastic fibers. Cells that can replenish these components are desirable for cell-based therapy. Intravenously injected multilineage-differentiating stress-enduring (Muse) cells, endogenous nontumorigenic pluripotent-like stem cells, reportedly integrate into the damaged site and repair the tissue through spontaneous differentiation into tissue-compatible cells...
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29557519/protein-availability-and-satellite-cell-dynamics-in-skeletal-muscle
#18
REVIEW
Baubak Shamim, John A Hawley, Donny M Camera
Human skeletal muscle satellite cells are activated in response to both resistance and endurance exercise. It was initially proposed that satellite cell proliferation and differentiation were only required to support resistance exercise-induced hypertrophy. However, satellite cells may also play a role in muscle fibre remodelling after endurance-based exercise and extracellular matrix regulation. Given the importance of dietary protein, particularly branched chain amino acids, in supporting myofibrillar and mitochondrial adaptations to both resistance and endurance-based training, a greater understanding of how protein intake impacts satellite cell activity would provide further insight into the mechanisms governing skeletal muscle remodelling with exercise...
June 2018: Sports Medicine
https://www.readbyqxmd.com/read/29528394/calpain-3-and-camkii%C3%AE-signaling-are-required-to-induce-hsp70-necessary-for-adaptive-muscle-growth-after-atrophy
#19
Irina Kramerova, Jorge A Torres, Ascia Eskin, Stanley F Nelson, Melissa J Spencer
Mutations in CAPN3 cause autosomal recessive limb girdle muscular dystrophy 2A. Calpain 3 (CAPN3) is a calcium dependent protease residing in the myofibrillar, cytosolic and triad fractions of skeletal muscle. At the triad, it colocalizes with calcium calmodulin kinase IIβ (CaMKIIβ). CAPN3 knock out mice (C3KO) show reduced triad integrity and blunted CaMKIIβ signaling, which correlates with impaired transcriptional activation of myofibrillar and oxidative metabolism genes in response to running exercise...
May 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29487509/enduring-effects-of-paternal-deprivation-in-california-mice-peromyscus-californicus-behavioral-dysfunction-and-sex-dependent-alterations-in-hippocampal-new-cell-survival
#20
Erica R Glasper, Molly M Hyer, Terrence J Hunter
Early-life experiences with caregivers can significantly affect offspring development in human and non-human animals. While much of our knowledge of parent-offspring relationships stem from mother-offspring interactions, increasing evidence suggests interactions with the father are equally as important and can prevent social, behavioral, and neurological impairments that may appear early in life and have enduring consequences in adulthood. In the present study, we utilized the monogamous and biparental California mouse ( Peromyscus californicus )...
2018: Frontiers in Behavioral Neuroscience
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