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https://www.readbyqxmd.com/read/30553841/platelet-derived-growth-factor-d-enables-liver-myofibroblasts-to-promote-tumor-lymphangiogenesis-in-cholangiocarcinoma
#1
Massimiliano Cadamuro, Simone Brivio, Joachim Mertens, Marta Vismara, Anja Moncsek, Chiara Milani, Christian Fingas, Maria Cristina Malerba, Giorgia Nardo, Luigi Dall'Olmo, Eleonora Milani, Valeria Mariotti, Tommaso Stecca, Marco Massani, Carlo Spirli, Romina Fiorotto, Stefano Indraccolo, Mario Strazzabosco, Luca Fabris
BACKGROUND: /Aims. In cholangiocarcinoma, early metastatic spread via lymphatic vessels often precludes curative therapies. Cholangiocarcinoma invasiveness is fostered by an extensive stromal reaction, enriched in cancer-associated fibroblasts (CAF) and lymphatic endothelial cells (LEC). Cholangiocarcinoma cells recruit and activate CAF by secreting PDGF-D. Here we investigated the role of PDGF-D and liver myofibroblasts in promoting lymphangiogenesis in cholangiocarcinoma. METHODS: Human cholangiocarcinoma specimens were immunostained for podoplanin (LEC marker), α-SMA (CAF), VEGF-A, VEGF-C, and their cognate receptors (VEGFR2, VEGFR3)...
December 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30553700/the-oral-splicing-modifier-rg7800-increases-full-length-survival-of-motor-neuron-2-mrna-and-survival-of-motor-neuron-protein-results-from-trials-in-healthy-adults-and-patients-with-spinal-muscular-atrophy
#2
Heidemarie Kletzl, Anne Marquet, Andreas Günther, Wakana Tang, Jules Heuberger, Geert Jan Groeneveld, Willem Birkhoff, Eugenio Mercuri, Hanns Lochmüller, Claire Wood, Dirk Fischer, Irene Gerlach, Katja Heinig, Teodorica Bugawan, Sebastian Dziadek, Russell Kinch, Christian Czech, Omar Khwaja
Spinal muscular atrophy (SMA) is a rare genetic and progressively debilitating neuromuscular disease. It is the leading genetic cause of death among infants. In SMA, low levels of survival of motor neuron (SMN) protein lead to motor neuron death and muscle atrophy as the SMN protein is critical to motor neuron survival. SMA is caused by mutations in, or deletion of, the SMN1 gene. A second SMN gene, SMN2, produces only low levels of functional SMN protein due to alternative splicing which excludes exon 7 from most transcripts, generating truncated, rapidly degraded SMN protein...
October 30, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/30551262/diagnostic-leukapheresis-for-ctc-analysis-in-breast-cancer-patients-ctc-frequency-clinical-experiences-and-recommendations-for-standardized-reporting
#3
Tanja N Fehm, Franziska Meier-Stiegen, Christiane Driemel, Bernadette Jäger, Florian Reinhardt, Johanna Naskou, André Franken, Hans Neubauer, Rui P L Neves, Guus van Dalum, Eugen Ruckhäberle, Dieter Niederacher, Jutta M Rox, Johannes C Fischer, Nikolas H Stoecklein
Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. As epithelial cells have a similar density, DLA cocollects circulating tumor cell (CTCs) along with the targeted mononuclear cells. Here, we report on our single center experience applying DLA in 40 nonmetastatic and metastatic breast cancer patients and its impact on CTC detection. We found that the use of just 5% of the DLA product (corresponding to a median peripheral blood volume of around 60 ml) in the CellSearch® assay already leads to a significant increase in CTC detection frequency and yield...
December 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/30548928/double-blinded-randomized-controlled-trial-to-evaluate-a-multimedia-surgical-care-tour-in-improving-patient-satisfaction-and-knowledge-after-functional-endoscopic-sinus-surgery
#4
Yue Ma, Josh Zeiger, Sean McKee, Anthony Yang, Madeleine Schaberg, Anthony Del-Signore, Satish Govindaraj, Alfred Iloreta
BACKGROUND: Current delivery of patient education is done during the clinic visit, where physicians or clinic staff have limited time for each patient. One potential solution is to provide a multimedia surgical care tour delivered to patients throughout the perioperative period. The purpose of the study is to evaluate the effectiveness of this surgical care tour in enhancing patient knowledge and satisfaction after functional endoscopic sinus surgery (FESS). METHODS: A total of 121 patients were enrolled and a double-blinded randomized controlled trial was initiated...
December 13, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30548618/molecular-signatures-of-increased-freezing-tolerance-due-to-low-temperature-memory-in-arabidopsis
#5
Ellen Zuther, Stephanie Schaarschmidt, Axel Fischer, Alexander Erban, Majken Pagter, Umarah Mubeen, Patrick Giavalisco, Joachim Kopka, Heike Sprenger, Dirk K Hincha
Alternating temperatures require fast and coordinated adaptation responses of plants. Cold acclimation has been extensively investigated and results in increased freezing tolerance in Arabidopsis thaliana. Here we show that the two Arabidopsis accessions Col-0 and N14 that differ in their freezing tolerance, showed memory of cold acclimation, i.e. cold priming. Freezing tolerance was higher in plants exposed to cold priming at 4°C, a lag phase at 20°C and a second triggering cold stress (4°C) than in plants that were only cold primed...
December 12, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/30548353/tramadol-dispensing-patterns-and-trends-in-canada-2007-2016
#6
Benedikt Fischer, Paul Kurdyak, Wayne Jones
PURPOSE: Opioid use and associated mortality and morbidity have substantially increased in Canada, which recent interventions have aimed to reduce. Tramadol is an atypical prescription-only (but unscheduled under Canada's narcotics law) opioid analgesic and not subject to controls for other (eg, strong) opioids. Given experiences in different jurisdictions, tramadol may have been increasingly dispensed as a "substitute" drug during a period with increasingly restrictive controls for other (scheduled) opioids...
December 12, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/30548259/vulval-crohn-disease-a-case-series-of-26-patients
#7
Emily Forward, Nianda Reid, Gayle Fischer
Vulval Crohn disease is rare and likely under-reported, leading to difficulty in diagnosis and delay in treatment. In this case series, we report the clinical features and discuss therapy in 26 consecutive patients with vulval Crohn disease, with or without documented gastrointestinal disease, presenting between January 2016 and July 2018. We highlight the need for treatment that is in some cases more aggressive than the requirement to manage the patient's gastrointestinal involvement.
December 11, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/30547617/evidence-for-the-associated-production-of-a-single-top-quark-and-a-photon-in-proton-proton-collisions-at-sqrt-s-13-tev
#8
A M Sirunyan, A Tumasyan, W Adam, F Ambrogi, E Asilar, T Bergauer, J Brandstetter, M Dragicevic, J Erö, A Escalante Del Valle, M Flechl, R Frühwirth, V M Ghete, J Hrubec, M Jeitler, N Krammer, I Krätschmer, D Liko, T Madlener, I Mikulec, N Rad, H Rohringer, J Schieck, R Schöfbeck, M Spanring, D Spitzbart, A Taurok, W Waltenberger, J Wittmann, C-E Wulz, M Zarucki, V Chekhovsky, V Mossolov, J Suarez Gonzalez, E A De Wolf, D Di Croce, X Janssen, J Lauwers, M Pieters, H Van Haevermaet, P Van Mechelen, N Van Remortel, S Abu Zeid, F Blekman, J D'Hondt, I De Bruyn, J De Clercq, K Deroover, G Flouris, D Lontkovskyi, S Lowette, I Marchesini, S Moortgat, L Moreels, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, D Beghin, B Bilin, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, B Dorney, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, A K Kalsi, T Lenzi, J Luetic, N Postiau, E Starling, L Thomas, C Vander Velde, P Vanlaer, D Vannerom, Q Wang, T Cornelis, D Dobur, A Fagot, M Gul, I Khvastunov, D Poyraz, C Roskas, D Trocino, M Tytgat, W Verbeke, B Vermassen, M Vit, N Zaganidis, H Bakhshiansohi, O Bondu, S Brochet, G Bruno, C Caputo, P David, C Delaere, M Delcourt, B Francois, A Giammanco, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, K Piotrzkowski, A Saggio, M Vidal Marono, S Wertz, J Zobec, F L Alves, G A Alves, M Correa Martins Junior, G Correia Silva, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, E Coelho, E M Da Costa, G G Da Silveira, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, H Malbouisson, D Matos Figueiredo, M Melo De Almeida, C Mora Herrera, L Mundim, H Nogima, W L Prado Da Silva, L J Sanchez Rosas, A Santoro, A Sznajder, M Thiel, E J Tonelli Manganote, F Torres Da Silva De Araujo, A Vilela Pereira, S Ahuja, C A Bernardes, L Calligaris, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, S F Novaes, Sandra S Padula, A Aleksandrov, R Hadjiiska, P Iaydjiev, A Marinov, M Misheva, M Rodozov, M Shopova, G Sultanov, A Dimitrov, L Litov, B Pavlov, P Petkov, W Fang, X Gao, L Yuan, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, C H Jiang, D Leggat, H Liao, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, Z Wang, E Yazgan, H Zhang, S Zhang, J Zhao, Y Ban, G Chen, A Levin, J Li, L Li, Q Li, Y Mao, S J Qian, D Wang, Z Xu, Y Wang, C Avila, A Cabrera, C A Carrillo Montoya, L F Chaparro Sierra, C Florez, C F González Hernández, M A Segura Delgado, B Courbon, N Godinovic, D Lelas, I Puljak, T Sculac, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, B Mesic, A Starodumov, T Susa, M W Ather, A Attikis, M Kolosova, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Finger, M Finger, E Ayala, E Carrera Jarrin, H Abdalla, A A Abdelalim, E Salama, S Bhowmik, A Carvalho Antunes De Oliveira, R K Dewanjee, K Ehataht, M Kadastik, M Raidal, C Veelken, P Eerola, H Kirschenmann, J Pekkanen, M Voutilainen, J Havukainen, J K Heikkilä, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Laurila, S Lehti, T Lindén, P Luukka, T Mäenpää, H Siikonen, E Tuominen, J Tuominiemi, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, J L Faure, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, C Leloup, E Locci, J Malcles, G Negro, J Rander, A Rosowsky, M Ö Sahin, M Titov, A Abdulsalam, C Amendola, I Antropov, F Beaudette, P Busson, C Charlot, R Granier de Cassagnac, I Kucher, A Lobanov, J Martin Blanco, C Martin Perez, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, J Rembser, R Salerno, J B Sauvan, Y Sirois, A G Stahl Leiton, A Zabi, A Zghiche, J-L Agram, J Andrea, D Bloch, J-M Brom, E C Chabert, V Cherepanov, C Collard, E Conte, J-C Fontaine, D Gelé, U Goerlach, M Jansová, A-C Le Bihan, N Tonon, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, N Chanon, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fay, L Finco, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, H Lattaud, M Lethuillier, L Mirabito, S Perries, A Popov, V Sordini, G Touquet, M Vander Donckt, S Viret, A Khvedelidze, Z Tsamalaidze, C Autermann, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, M P Rauch, C Schomakers, J Schulz, M Teroerde, B Wittmer, V Zhukov, A Albert, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, S Ghosh, A Güth, T Hebbeker, C Heidemann, K Hoepfner, H Keller, L Mastrolorenzo, M Merschmeyer, A Meyer, P Millet, S Mukherjee, T Pook, M Radziej, H Reithler, M Rieger, A Schmidt, D Teyssier, S Thüer, G Flügge, O Hlushchenko, T Kress, A Künsken, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, D Roy, H Sert, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, I Babounikau, K Beernaert, O Behnke, U Behrens, A Bermúdez Martínez, D Bertsche, A A Bin Anuar, K Borras, V Botta, A Campbell, P Connor, C Contreras-Campana, V Danilov, A De Wit, M M Defranchis, C Diez Pardos, D Domínguez Damiani, G Eckerlin, T Eichhorn, A Elwood, E Eren, E Gallo, A Geiser, A Grohsjean, M Guthoff, M Haranko, A Harb, J Hauk, H Jung, M Kasemann, J Keaveney, C Kleinwort, J Knolle, D Krücker, W Lange, A Lelek, T Lenz, J Leonard, K Lipka, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, M Meyer, M Missiroli, G Mittag, J Mnich, V Myronenko, S K Pflitsch, D Pitzl, A Raspereza, M Savitskyi, P Saxena, P Schütze, C Schwanenberger, R Shevchenko, A Singh, H Tholen, O Turkot, A Vagnerini, G P Van Onsem, R Walsh, Y Wen, K Wichmann, C Wissing, O Zenaiev, R Aggleton, S Bein, L Benato, A Benecke, V Blobel, T Dreyer, E Garutti, D Gonzalez, P Gunnellini, J Haller, A Hinzmann, A Karavdina, G Kasieczka, R Klanner, R Kogler, N Kovalchuk, S Kurz, V Kutzner, J Lange, D Marconi, J Multhaup, M Niedziela, C E N Niemeyer, D Nowatschin, A Perieanu, A Reimers, O Rieger, C Scharf, P Schleper, S Schumann, J Schwandt, J Sonneveld, H Stadie, G Steinbrück, F M Stober, M Stöver, A Vanhoefer, B Vormwald, I Zoi, M Akbiyik, C Barth, M Baselga, S Baur, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, K El Morabit, N Faltermann, B Freund, M Giffels, M A Harrendorf, F Hartmann, S M Heindl, U Husemann, F Kassel, I Katkov, S Kudella, H Mildner, S Mitra, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, A Kyriakis, D Loukas, G Paspalaki, I Topsis-Giotis, G Karathanasis, S Kesisoglou, P Kontaxakis, A Panagiotou, I Papavergou, N Saoulidou, E Tziaferi, K Vellidis, K Kousouris, I Papakrivopoulos, G Tsipolitis, I Evangelou, C Foudas, P Gianneios, P Katsoulis, P Kokkas, S Mallios, N Manthos, I Papadopoulos, E Paradas, J Strologas, F A Triantis, D Tsitsonis, M Bartók, M Csanad, N Filipovic, P Major, M I Nagy, G Pasztor, O Surányi, G I Veres, G Bencze, C Hajdu, D Horvath, Á Hunyadi, F Sikler, T Á Vámi, V Veszpremi, G Vesztergombi, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, P Raics, Z L Trocsanyi, B Ujvari, S Choudhury, J R Komaragiri, P C Tiwari, S Bahinipati, C Kar, P Mal, K Mandal, A Nayak, D K Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, S Chauhan, R Chawla, N Dhingra, R Gupta, A Kaur, M Kaur, S Kaur, R Kumar, P Kumari, M Lohan, A Mehta, K Sandeep, S Sharma, J B Singh, A K Virdi, G Walia, A Bhardwaj, B C Choudhary, R B Garg, M Gola, S Keshri, Ashok Kumar, S Malhotra, M Naimuddin, P Priyanka, K Ranjan, Aashaq Shah, R Sharma, R Bhardwaj, M Bharti, R Bhattacharya, S Bhattacharya, U Bhawandeep, D Bhowmik, S Dey, S Dutt, S Dutta, S Ghosh, K Mondal, S Nandan, A Purohit, P K Rout, A Roy, S Roy Chowdhury, G Saha, S Sarkar, M Sharan, B Singh, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, P K Netrakanti, L M Pant, P Shukla, T Aziz, M A Bhat, S Dugad, G B Mohanty, N Sur, B Sutar, Ravindra Kumar Verma, S Banerjee, S Bhattacharya, S Chatterjee, P Das, M Guchait, Sa Jain, S Karmakar, S Kumar, M Maity, G Majumder, K Mazumdar, N Sahoo, T Sarkar, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, M Khakzad, M Mohammadi Najafabadi, M Naseri, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, A Di Florio, F Errico, L Fiore, A Gelmi, G Iaselli, M Ince, S Lezki, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Zito, G Abbiendi, C Battilana, D Bonacorsi, L Borgonovi, S Braibant-Giacomelli, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, C Ciocca, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, E Fontanesi, P Giacomelli, C Grandi, L Guiducci, F Iemmi, S Lo Meo, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, F Primavera, T Rovelli, G P Siroli, N Tosi, S Albergo, A Di Mattia, R Potenza, A Tricomi, C Tuve, G Barbagli, K Chatterjee, V Ciulli, C Civinini, R D'Alessandro, E Focardi, G Latino, P Lenzi, M Meschini, S Paoletti, L Russo, G Sguazzoni, D Strom, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Ferro, F Ravera, E Robutti, S Tosi, A Benaglia, A Beschi, L Brianza, F Brivio, V Ciriolo, S Di Guida, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, A Massironi, D Menasce, F Monti, L Moroni, M Paganoni, D Pedrini, S Ragazzi, T Tabarelli de Fatis, D Zuolo, S Buontempo, N Cavallo, A Di Crescenzo, F Fabozzi, F Fienga, G Galati, A O M Iorio, W A Khan, L Lista, S Meola, P Paolucci, C Sciacca, E Voevodina, P Azzi, N Bacchetta, D Bisello, A Boletti, A Bragagnolo, R Carlin, P Checchia, M Dall'Osso, P De Castro Manzano, T Dorigo, U Dosselli, F Gasparini, U Gasparini, A Gozzelino, S Y Hoh, S Lacaprara, P Lujan, M Margoni, A T Meneguzzo, J Pazzini, P Ronchese, R Rossin, F Simonetto, A Tiko, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, M Ressegotti, C Riccardi, P Salvini, I Vai, P Vitulo, M Biasini, G M Bilei, C Cecchi, D Ciangottini, L Fanò, P Lariccia, R Leonardi, E Manoni, G Mantovani, V Mariani, M Menichelli, A Rossi, A Santocchia, D Spiga, K Androsov, P Azzurri, G Bagliesi, L Bianchini, T Boccali, L Borrello, R Castaldi, M A Ciocci, R Dell'Orso, G Fedi, F Fiori, L Giannini, A Giassi, M T Grippo, F Ligabue, E Manca, G Mandorli, A Messineo, F Palla, A Rizzi, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, D Del Re, E Di Marco, M Diemoz, S Gelli, E Longo, B Marzocchi, P Meridiani, G Organtini, F Pandolfi, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, F Cenna, S Cometti, M Costa, R Covarelli, N Demaria, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, D Soldi, A Staiano, S Belforte, V Candelise, M Casarsa, F Cossutti, A Da Rold, G Della Ricca, F Vazzoler, A Zanetti, D H Kim, G N Kim, M S Kim, J Lee, S Lee, S W Lee, C S Moon, Y D Oh, S I Pak, S Sekmen, D C Son, Y C Yang, H Kim, D H Moon, G Oh, J Goh, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, H S Kim, J Almond, J Kim, J S Kim, H Lee, K Lee, K Nam, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, D Jeon, H Kim, J H Kim, J S H Lee, I C Park, Y Choi, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, J F Benitez, A Castaneda Hernandez, J A Murillo Quijada, H Castilla-Valdez, E De La Cruz-Burelo, M C Duran-Osuna, I Heredia-De La Cruz, R Lopez-Fernandez, J Mejia Guisao, R I Rabadan-Trejo, M Ramirez-Garcia, G Ramirez-Sanchez, R Reyes-Almanza, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, J Eysermans, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, S Bheesette, P H Butler, A Ahmad, M Ahmad, M I Asghar, Q Hassan, H R Hoorani, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, M Szleper, P Traczyk, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, A Pyskir, M Walczak, M Araujo, P Bargassa, C Beirão Da Cruz E Silva, A Di Francesco, P Faccioli, B Galinhas, M Gallinaro, J Hollar, N Leonardo, M V Nemallapudi, J Seixas, G Strong, O Toldaiev, D Vadruccio, J Varela, S Afanasiev, P Bunin, M Gavrilenko, I Golutvin, I Gorbunov, A Kamenev, V Karjavine, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, S Shmatov, S Shulha, N Skatchkov, V Smirnov, N Voytishin, A Zarubin, V Golovtsov, Y Ivanov, V Kim, E Kuznetsova, P Levchenko, V Murzin, V Oreshkin, I Smirnov, D Sosnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, I Pozdnyakov, G Safronov, A Spiridonov, A Stepennov, V Stolin, M Toms, E Vlasov, A Zhokin, T Aushev, R Chistov, M Danilov, P Parygin, D Philippov, S Polikarpov, E Tarkovskii, V Andreev, M Azarkin, I Dremin, M Kirakosyan, S V Rusakov, A Terkulov, A Baskakov, A Belyaev, E Boos, V Bunichev, M Dubinin, L Dudko, V Klyukhin, O Kodolova, N Korneeva, I Lokhtin, I Miagkov, S Obraztsov, M Perfilov, V Savrin, P Volkov, A Barnyakov, V Blinov, T Dimova, L Kardapoltsev, Y Skovpen, I Azhgirey, I Bayshev, S Bitioukov, D Elumakhov, A Godizov, V Kachanov, A Kalinin, D Konstantinov, P Mandrik, V Petrov, R Ryutin, S Slabospitskii, A Sobol, S Troshin, N Tyurin, A Uzunian, A Volkov, A Babaev, S Baidali, V Okhotnikov, P Adzic, P Cirkovic, D Devetak, M Dordevic, J Milosevic, J Alcaraz Maestre, A Álvarez Fernández, I Bachiller, M Barrio Luna, J A Brochero Cifuentes, M Cerrada, N Colino, B De La Cruz, A Delgado Peris, C Fernandez Bedoya, J P Fernández Ramos, J Flix, M C Fouz, O Gonzalez Lopez, S Goy Lopez, J M Hernandez, M I Josa, D Moran, A Pérez-Calero Yzquierdo, J Puerta Pelayo, I Redondo, L Romero, M S Soares, A Triossi, C Albajar, J F de Trocóniz, J Cuevas, C Erice, J Fernandez Menendez, S Folgueras, I Gonzalez Caballero, J R González Fernández, E Palencia Cortezon, V Rodríguez Bouza, S Sanchez Cruz, P Vischia, J M Vizan Garcia, I J Cabrillo, A Calderon, B Chazin Quero, J Duarte Campderros, M Fernandez, P J Fernández Manteca, A García Alonso, J Garcia-Ferrero, G Gomez, A Lopez Virto, J Marco, C Martinez Rivero, P Martinez Ruiz Del Arbol, F Matorras, J Piedra Gomez, C Prieels, T Rodrigo, A Ruiz-Jimeno, L Scodellaro, N Trevisani, I Vila, R Vilar Cortabitarte, N Wickramage, D Abbaneo, B Akgun, E Auffray, G Auzinger, P Baillon, A H Ball, D Barney, J Bendavid, M Bianco, A Bocci, C Botta, E Brondolin, T Camporesi, M Cepeda, G Cerminara, E Chapon, Y Chen, G Cucciati, D d'Enterria, A Dabrowski, N Daci, V Daponte, A David, A De Roeck, N Deelen, M Dobson, M Dünser, N Dupont, A Elliott-Peisert, P Everaerts, F Fallavollita, D Fasanella, G Franzoni, J Fulcher, W Funk, D Gigi, A Gilbert, K Gill, F Glege, M Guilbaud, D Gulhan, J Hegeman, C Heidegger, V Innocente, A Jafari, P Janot, O Karacheban, J Kieseler, A Kornmayer, M Krammer, C Lange, P Lecoq, C Lourenço, L Malgeri, M Mannelli, F Meijers, J A Merlin, S Mersi, E Meschi, P Milenovic, F Moortgat, M Mulders, J Ngadiuba, S Nourbakhsh, S Orfanelli, L Orsini, F Pantaleo, L Pape, E Perez, M Peruzzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, F M Pitters, D Rabady, A Racz, T Reis, G Rolandi, M Rovere, H Sakulin, C Schäfer, C Schwick, M Seidel, M Selvaggi, A Sharma, P Silva, P Sphicas, A Stakia, J Steggemann, M Tosi, D Treille, A Tsirou, V Veckalns, M Verzetti, W D Zeuner, L Caminada, K Deiters, W Erdmann, R Horisberger, Q Ingram, H C Kaestli, D Kotlinski, U Langenegger, T Rohe, S A Wiederkehr, M Backhaus, L Bäni, P Berger, N Chernyavskaya, G Dissertori, M Dittmar, M Donegà, C Dorfer, T A Gómez Espinosa, C Grab, D Hits, T Klijnsma, W Lustermann, R A Manzoni, M Marionneau, M T Meinhard, F Micheli, P Musella, F Nessi-Tedaldi, J Pata, F Pauss, G Perrin, L Perrozzi, S Pigazzini, M Quittnat, C Reissel, D Ruini, D A Sanz Becerra, M Schönenberger, L Shchutska, V R Tavolaro, K Theofilatos, M L Vesterbacka Olsson, R Wallny, D H Zhu, T K Aarrestad, C Amsler, D Brzhechko, M F Canelli, A De Cosa, R Del Burgo, S Donato, C Galloni, T Hreus, B Kilminster, S Leontsinis, I Neutelings, D Pinna, G Rauco, P Robmann, D Salerno, K Schweiger, C Seitz, Y Takahashi, A Zucchetta, Y H Chang, K Y Cheng, T H Doan, R Khurana, C M Kuo, W Lin, A Pozdnyakov, S S Yu, P Chang, Y Chao, K F Chen, P H Chen, W-S Hou, Arun Kumar, Y F Liu, R-S Lu, E Paganis, A Psallidas, A Steen, B Asavapibhop, N Srimanobhas, N Suwonjandee, A Bat, F Boran, S Cerci, S Damarseckin, Z S Demiroglu, F Dolek, C Dozen, I Dumanoglu, S Girgis, G Gokbulut, Y Guler, E Gurpinar, I Hos, C Isik, E E Kangal, O Kara, A Kayis Topaksu, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, D Sunar Cerci, B Tali, U G Tok, S Turkcapar, I S Zorbakir, C Zorbilmez, B Isildak, G Karapinar, M Yalvac, M Zeyrek, I O Atakisi, E Gülmez, M Kaya, O Kaya, S Ozkorucuklu, S Tekten, E A Yetkin, M N Agaras, A Cakir, K Cankocak, Y Komurcu, S Sen, B Grynyov, L Levchuk, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, O Davignon, H Flacher, J Goldstein, G P Heath, H F Heath, L Kreczko, D M Newbold, S Paramesvaran, B Penning, T Sakuma, D Smith, V J Smith, J Taylor, A Titterton, K W Bell, A Belyaev, C Brew, R M Brown, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Linacre, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, W J Womersley, R Bainbridge, P Bloch, J Borg, S Breeze, O Buchmuller, A Bundock, D Colling, P Dauncey, G Davies, M Della Negra, R Di Maria, Y Haddad, G Hall, G Iles, T James, M Komm, C Laner, L Lyons, A-M Magnan, S Malik, A Martelli, J Nash, A Nikitenko, V Palladino, M Pesaresi, D M Raymond, A Richards, A Rose, E Scott, C Seez, A Shtipliyski, G Singh, M Stoye, T Strebler, S Summers, A Tapper, K Uchida, T Virdee, N Wardle, D Winterbottom, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, C K Mackay, A Morton, I D Reid, L Teodorescu, S Zahid, K Call, J Dittmann, K Hatakeyama, H Liu, C Madrid, B Mcmaster, N Pastika, C Smith, R Bartek, A Dominguez, A Buccilli, S I Cooper, C Henderson, P Rumerio, C West, D Arcaro, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, X Coubez, D Cutts, M Hadley, J Hakala, U Heintz, J M Hogan, K H M Kwok, E Laird, G Landsberg, J Lee, Z Mao, M Narain, S Sagir, R Syarif, E Usai, D Yu, R Band, C Brainerd, R Breedon, D Burns, M Calderon De La Barca Sanchez, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, W Ko, O Kukral, R Lander, M Mulhearn, D Pellett, J Pilot, S Shalhout, M Shi, D Stolp, D Taylor, K Tos, M Tripathi, Z Wang, F Zhang, M Bachtis, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, S Regnard, D Saltzberg, C Schnaible, V Valuev, E Bouvier, K Burt, R Clare, J W Gary, S M A Ghiasi Shirazi, G Hanson, G Karapostoli, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, W Si, L Wang, H Wei, S Wimpenny, B R Yates, J G Branson, P Chang, S Cittolin, M Derdzinski, R Gerosa, D Gilbert, B Hashemi, A Holzner, D Klein, G Kole, V Krutelyov, J Letts, M Masciovecchio, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, M Citron, A Dishaw, V Dutta, M Franco Sevilla, L Gouskos, R Heller, J Incandela, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, S Wang, J Yoo, D Anderson, A Bornheim, J M Lawhorn, H B Newman, T Q Nguyen, M Spiropulu, J R Vlimant, R Wilkinson, S Xie, Z Zhang, R Y Zhu, M B Andrews, T Ferguson, T Mudholkar, M Paulini, M Sun, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, E MacDonald, T Mulholland, R Patel, K Stenson, K A Ulmer, S R Wagner, J Alexander, J Chaves, Y Cheng, J Chu, A Datta, K Mcdermott, N Mirman, J R Patterson, D Quach, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, S Abdullin, M Albrow, M Alyari, G Apollinari, A Apresyan, A Apyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, A Canepa, G B Cerati, H W K Cheung, F Chlebana, M Cremonesi, J Duarte, V D Elvira, J Freeman, Z Gecse, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, M J Kortelainen, B Kreis, S Lammel, D Lincoln, R Lipton, M Liu, T Liu, J Lykken, K Maeshima, J M Marraffino, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, C Pena, O Prokofyev, G Rakness, L Ristori, A Savoy-Navarro, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, L Cadamuro, A Carnes, M Carver, D Curry, R D Field, S V Gleyzer, B M Joshi, J Konigsberg, A Korytov, K H Lo, P Ma, K Matchev, H Mei, G Mitselmakher, D Rosenzweig, K Shi, D Sperka, J Wang, S Wang, X Zuo, Y R Joshi, S Linn, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, C Schiber, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, M Rahmani, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, S Dittmer, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, C Mills, I D Sandoval Gonzalez, M B Tonjes, H Trauger, N Varelas, H Wang, X Wang, Z Wu, J Zhang, M Alhusseini, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, W T Hung, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, A Bylinkin, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Rogan, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, S Duric, A Ivanov, K Kaadze, D Kim, Y Maravin, D R Mendis, T Mitchell, A Modak, A Mohammadi, L K Saini, N Skhirtladze, F Rebassoo, D Wright, A Baden, O Baron, A Belloni, S C Eno, Y Feng, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, S Nabili, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, K Wong, D Abercrombie, B Allen, V Azzolini, A Baty, G Bauer, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, P Harris, D Hsu, M Hu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y-J Lee, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, G S F Stephans, K Sumorok, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, S Zhaozhong, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, Sh Jain, S Kalafut, Y Kubota, Z Lesko, J Mans, N Ruckstuhl, R Rusack, J Turkewitz, M A Wadud, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, F Golf, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, A Godshalk, C Harrington, I Iashvili, A Kharchilava, C Mclean, D Nguyen, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, C Freer, A Hortiangtham, D M Morse, T Orimoto, R Teixeira De Lima, T Wamorkar, B Wang, A Wisecarver, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, M H Schmitt, K Sung, M Trovato, M Velasco, R Bucci, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, W Li, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, P Siddireddy, G Smith, S Taroni, M Wayne, A Wightman, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, T Y Ling, W Luo, B L Winer, S Cooperstein, P Elmer, J Hardenbrook, S Higginbotham, A Kalogeropoulos, D Lange, M T Lucchini, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, J Salfeld-Nebgen, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, S Das, L Gutay, M Jones, A W Jung, A Khatiwada, B Mahakud, D H Miller, N Neumeister, C C Peng, S Piperov, H Qiu, J F Schulte, J Sun, F Wang, R Xiao, W Xie, T Cheng, J Dolen, N Parashar, Z Chen, K M Ecklund, S Freed, F J M Geurts, M Kilpatrick, W Li, B P Padley, R Redjimi, J Roberts, J Rorie, W Shi, Z Tu, J Zabel, A Zhang, A Bodek, P de Barbaro, R Demina, Y T Duh, J L Dulemba, C Fallon, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, P Tan, R Taus, A Agapitos, J P Chou, Y Gershtein, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, J Heideman, G Riley, S Spanier, O Bouhali, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, S Luo, R Mueller, A Perloff, L Perniè, D Rathjens, A Safonov, N Akchurin, J Damgov, F De Guio, P R Dudero, S Kunori, K Lamichhane, S W Lee, T Mengke, S Muthumuni, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, J D Ruiz Alvarez, P Sheldon, S Tuo, J Velkovska, M Verweij, Q Xu, M W Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, K Long, R Loveless, T Ruggles, A Savin, V Sharma, N Smith, W H Smith, N Woods
The first evidence of events consistent with the production of a single top quark in association with a photon is reported. The analysis is based on proton-proton collisions at sqrt[s]=13  TeV and recorded by the CMS experiment in 2016, corresponding to an integrated luminosity of 35.9  fb^{-1}. Events are selected by requiring the presence of a muon (μ), a photon (γ), an imbalance in transverse momentum from an undetected neutrino (ν), and at least two jets (j) of which exactly one is identified as associated with the hadronization of a b quark...
November 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30547287/measurement-of-il-17aa-and-il-17ff-as-pharmacodynamic-biomarkers-to-demonstrate-target-engagement-in-the-phase-i-study-of-mcaf5352a
#9
Kun Peng, Yehong Wang, Ketevan Siradze, Rich Erickson, Saloumeh K Fischer, Tracy L Staton
The interleukin (IL)-17 pathway has been implicated in the pathophysiology of many autoimmune diseases. MCAF5352A is a humanized monoclonal antibody which targets both IL-17A and IL-17F, thereby inhibiting the activity of IL-17 dimers (IL-17AA, IL-17AF, and IL-17FF). The pharmacokinetic profile of MCAF5352A has been characterized in both a Phase Ia single ascending dose study and a Phase Ib multiple ascending dose study. Two qualified enzyme-linked immunosorbent assays were used to measure total IL-17AA and IL-17FF levels in serum as pharmacodynamic biomarkers in the Phase I studies...
December 13, 2018: AAPS Journal
https://www.readbyqxmd.com/read/30547087/multicomponent-new-particle-formation-from-sulfuric-acid-ammonia-and-biogenic-vapors
#10
Katrianne Lehtipalo, Chao Yan, Lubna Dada, Federico Bianchi, Mao Xiao, Robert Wagner, Dominik Stolzenburg, Lauri R Ahonen, Antonio Amorim, Andrea Baccarini, Paulus S Bauer, Bernhard Baumgartner, Anton Bergen, Anne-Kathrin Bernhammer, Martin Breitenlechner, Sophia Brilke, Angela Buchholz, Stephany Buenrostro Mazon, Dexian Chen, Xuemeng Chen, Antonio Dias, Josef Dommen, Danielle C Draper, Jonathan Duplissy, Mikael Ehn, Henning Finkenzeller, Lukas Fischer, Carla Frege, Claudia Fuchs, Olga Garmash, Hamish Gordon, Jani Hakala, Xucheng He, Liine Heikkinen, Martin Heinritzi, Johanna C Helm, Victoria Hofbauer, Christopher R Hoyle, Tuija Jokinen, Juha Kangasluoma, Veli-Matti Kerminen, Changhyuk Kim, Jasper Kirkby, Jenni Kontkanen, Andreas Kürten, Michael J Lawler, Huajun Mai, Serge Mathot, Roy L Mauldin, Ugo Molteni, Leonid Nichman, Wei Nie, Tuomo Nieminen, Andrea Ojdanic, Antti Onnela, Monica Passananti, Tuukka Petäjä, Felix Piel, Veronika Pospisilova, Lauriane L J Quéléver, Matti P Rissanen, Clémence Rose, Nina Sarnela, Simon Schallhart, Simone Schuchmann, Kamalika Sengupta, Mario Simon, Mikko Sipilä, Christian Tauber, António Tomé, Jasmin Tröstl, Olli Väisänen, Alexander L Vogel, Rainer Volkamer, Andrea C Wagner, Mingyi Wang, Lena Weitz, Daniela Wimmer, Penglin Ye, Arttu Ylisirniö, Qiaozhi Zha, Kenneth S Carslaw, Joachim Curtius, Neil M Donahue, Richard C Flagan, Armin Hansel, Ilona Riipinen, Annele Virtanen, Paul M Winkler, Urs Baltensperger, Markku Kulmala, Douglas R Worsnop
A major fraction of atmospheric aerosol particles, which affect both air quality and climate, form from gaseous precursors in the atmosphere. Highly oxygenated organic molecules (HOMs), formed by oxidation of biogenic volatile organic compounds, are known to participate in particle formation and growth. However, it is not well understood how they interact with atmospheric pollutants, such as nitrogen oxides (NO x ) and sulfur oxides (SO x ) from fossil fuel combustion, as well as ammonia (NH3 ) from livestock and fertilizers...
December 2018: Science Advances
https://www.readbyqxmd.com/read/30546492/rate-of-avascular-necrosis-after-fracture-dislocations-of-the-proximal-humerus-timing-of-surgery
#11
Marc Schnetzke, Julia Bockmeyer, Markus Loew, Stefan Studier-Fischer, Paul-Alfred Grützner, Thorsten Guehring
Background: Avascular necrosis (AVN) of the humeral head is a severe complication after proximal humerus fracture dislocations, and leads to a poorer clinical outcome and subsequent revision surgeries. The aim of the current study was to analyze the influence of time to surgery on the AVN rate after locked plating of dislocation fractures of the proximal humerus. Patients and methods: This retrospective study included 30 patients with a mean age of 63 ± 14 years with dislocation fractures of the proximal humerus type B3 or C3 according the AO/OTA classification...
2018: Obere Extremität
https://www.readbyqxmd.com/read/30545844/synaptotagmin-3-drives-ampa-receptor-endocytosis-depression-of-synapse-strength-and-forgetting
#12
Ankit Awasthi, Binu Ramachandran, Saheeb Ahmed, Eva Benito, Yo Shinoda, Noam Nitzan, Alina Heukamp, Sabine Rannio, Henrik Martens, Jonas Barth, Katja Burk, Yu Tian Wang, Andre Fischer, Camin Dean
Forgetting is important. Without it, the relative importance of acquired memories in a changing environment is lost. We discovered that Synaptotagmin-3 (Syt3) localizes to post-synaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation. AMPA receptor internalization, long-term-depression (LTD), and decay of long-term-potentiation (LTP) of synaptic strength required calcium-sensing by Syt3, and were abolished by Syt3 knockout. In spatial memory tasks Syt3 knockout mice learned normally, but exhibited a lack of forgetting...
December 13, 2018: Science
https://www.readbyqxmd.com/read/30545835/bruton-s-tyrosine-kinase-degradation-as-a-therapeutic-strategy-for-cancer
#13
Dennis Dobrovolsky, Eric S Wang, Sara Morrow, Catharine Leahy, Tyler Faust, Radosław P Nowak, Katherine A Donovan, Guang Yang, Zhengnian Li, Eric S Fischer, Steven P Treon, David M Weinstock, Nathanael S Gray
The covalent Bruton's Tyrosine Kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it is not selective for BTK and multiple mechanisms of resistance, including the C481S-BTK mutation, can compromise its efficacy. We hypothesized that small molecule-induced BTK degradation may overcome some of the limitations of traditional enzymatic inhibitors. Here, we demonstrate that BTK degradation results in potent suppression of signaling and proliferation in cancer cells, and that BTK degraders efficiently degrade C481S-BTK...
December 13, 2018: Blood
https://www.readbyqxmd.com/read/30545091/the-n-terminus-of-the-hiv-1-p6-gag-protein-regulates-susceptibility-to-degradation-by-ide
#14
Adrian Schmalen, Julia Karius-Fischer, Pia Rauch, Christian Setz, Klaus Korn, Petra Henklein, Torgils Fossen, Ulrich Schubert
As part of the Pr55Gag polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature HIV-1 p6 protein. Recently, we showed that p6 is a bona fide substrate of the insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease. This phenomenon appears to be specific for HIV-1, since p6 homologs of HIV-2, SIV and EIAV were IDE-insensitive. Furthermore, abrogation of the IDE-mediated degradation of p6 reduces the replication capacity of HIV-1 in an Env-dependent manner...
December 12, 2018: Viruses
https://www.readbyqxmd.com/read/30544510/matrix-metalloproteinase-response-of-dendritic-cell-gingival-epithelial-keratinocyte-and-t-cell-transwell-co-cultures-treated-with-porphyromonas-gingivalis-hemagglutinin-b
#15
Amber M Bates, Carol L Fischer, Vrushali P Abhyankar, Georgia K Johnson, Janet M Guthmiller, Ann Progulske-Fox, Kim A Brogden
Matrix metalloproteinases (MMPs) are enzymes involved in periodontal tissue destruction. Hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis induces an elevated MMP response in dendritic cells, but responses from cultures of single-cell types do not reflect the local tissue environment. The objective of this study was to measure HagB-induced MMP responses in a transwell co-culture system containing dendritic cells, gingival epithelial (GE) keratinocytes, and CD4+ T-cells. Transwell co-cultures were assembled and treated with or without HagB...
December 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30543151/changes-in-attachment-representation-in-psychotherapy-is-reflective-functioning-the-crucial-factor
#16
Anna Tmej, Melitta Fischer-Kern, Stephan Doering, Johanna Alexopoulos, Anna Buchheim
OBJECTIVES: The study analyzed the interdependence of change in attachment representation and reflective functioning (RF) in psychotherapy. METHODS: RF data from 63 female borderline personality disorder (BPD) patients were analyzed with respect to change of attachment representation (from insecure to secure and from unresolved to resolved) fromthree angles: (1) RF as a moderator variable, (2) RF as an outcome variable, and (3) RF changes over one year of treatment...
September 2018: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/30542544/high-electrical-conductivity-and-high-porosity-in-a-guest-mof-material-evidence-of-tcnq-ordering-within-cu-3-btc-2-micropores
#17
Christian Schneider, Dardan Ukaj, Raimund Koerver, A Alec Talin, Gregor Kieslich, Sidharam P Pujari, Han Zuilhof, Jürgen Janek, Mark D Allendorf, Roland A Fischer
The host-guest system TCNQ@Cu3 BTC2 (TCNQ = 7,7,8,8-tetracyanoquinodimethane, BTC = 1,3,5-benzenetricarboxylate) is a striking example of how semiconductivity can be introduced by guest incorporation in an otherwise insulating parent material. Exhibiting both microporosity and semiconducting behavior such materials offer exciting opportunities as next-generation sensor materials. Here, we apply a solvent-free vapor phase loading under rigorous exclusion of moisture, obtaining a series of the general formula x TCNQ@Cu3 BTC2 (0 ≤ x ≤ 1...
October 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/30542272/is-empathy-for-pain-unique-in-its-neural-correlates-a-meta-analysis-of-neuroimaging-studies-of-empathy
#18
Inge Timmers, Anna L Park, Molly D Fischer, Corey A Kronman, Lauren C Heathcote, J Maya Hernandez, Laura E Simons
Empathy is an essential component of our social lives, allowing us to understand and share other people's affective and sensory states, including pain. Evidence suggests a core neural network-including anterior insula (AI) and mid-cingulate cortex (MCC)-is involved in empathy for pain. However, a similar network is associated to empathy for non-pain affective states, raising the question whether empathy for pain is unique in its neural correlates. Furthermore, it is yet unclear whether neural correlates converge across different stimuli and paradigms that evoke pain-empathy...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30542210/microrna-29b-mediates-fibrotic-induction-of-human-xylosyltransferase-i-in-human-dermal-fibroblasts-via-the-sp1-pathway
#19
Lara Riedel, Bastian Fischer, Thanh-Diep Ly, Doris Hendig, Joachim Kuhn, Cornelius Knabbe, Isabel Faust
Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expression. XT-I has been characterized previously as a fibrosis biomarker catalyzing the key step of proteoglycan biosynthesis. While we demonstrate that XYLT1 is neither a target of microRNA-29b identified in silico nor a direct 3' untranslated region binding partner of microRNA-29b, transfection of normal human dermal fibroblasts with microRNA-29b inhibitor strongly increased XYLT1 mRNA expression and XT activity...
December 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30541879/extent-of-mhc-clustering-regulates-selectivity-and-effectiveness-of-t-cell-responses
#20
Nadia Anikeeva, Nicholas O Fischer, Craig D Blanchette, Yuri Sykulev
MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR engagement and TCR-mediated signaling has not been systematically studied. To evaluate the role of MHC clustering, we exploited nanoscale discoidal membrane mimetics (nanolipoprotein particles) to capture and present peptide-MHC (pMHC) ligands at various densities. We examined the binding of these model membrane clusters to the surface of live human CD8+ T cells and the subsequent triggering of intracellular signaling...
December 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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