keyword
https://read.qxmd.com/read/38371166/alterations-of-gastrointestinal-microbe-composition-in-various-human-diseases-and-its-significance-in-the-early-diagnosis-of-diseases
#21
REVIEW
Aman Agrawal, Ashish Anjankar
A 100 trillion bacteria, viruses, fungi, and archaea make up the human gut microbe. It has co-evolved with its human host and carries out essential tasks that improve general health. The relationship between gastrointestinal microbes and human health has been a growing field of interest and research in recent times. The gastrointestinal microbes are connected by complex networks and connections, and the host has given birth to the gut-microbe-brain axis, which shows the crucial effect that this circumstance could have on the health and diseases of the brain and spinal cord (or the central nervous system [CNS])...
January 2024: Curēus
https://read.qxmd.com/read/38368705/cortical-volume-abnormalities-in-schizophrenia-correlations-with-symptoms-and-cognitive-impairment
#22
JOURNAL ARTICLE
María Ángeles García-León, Paola Fuentes-Claramonte, Joan Soler-Vidal, Nuria Ramiro-Sousa, Pilar Salgado-Pineda, Josep Salavert, Llanos Torres, Amalia Guerrero-Pedraza, Josep Tristany, Andriana Karuk, Lucila Barbosa, Pablo Del Olmo-Encabo, Pedro Canut-Altemir, Josep Munuera, Salvador Sarró, Raymond Salvador, Peter J McKenna, Edith Pomarol-Clotet
BACKGROUND: Schizophrenic symptoms are known to segregate into reality distortion, negative and disorganization syndromes, but the correlates of these syndromes with regional brain structural change are not well established. Cognitive impairment is a further clinical feature of schizophrenia, whose brain structural correlates are the subject of conflicting findings. METHODS: 165 patients with schizophrenia were rated for symptoms using the PANSS, and cognitive impairment was indexed by estimated premorbid-current IQ discrepancy...
February 17, 2024: Schizophrenia Research
https://read.qxmd.com/read/38362845/the-genetic-epidemiology-of-schizotypal-personality-disorder
#23
JOURNAL ARTICLE
Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: The concept of schizotypal personality disorder (SPD) emerged from observations of personality characteristics common in relatives of schizophrenic patients. While often studied in family designs, few studies and none with genetic measures, have examined SPD in epidemiological samples. METHODS: We studied individuals born in Sweden 1940-2000 with an ICD-10 diagnosis of SPD with no prior schizophrenia (SZ) diagnosis ( n = 2292). Demographic features, patterns of comorbidity, and Family Genetic Risk Scores (FGRS) were assessed from multiple Swedish registries...
February 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38345122/impairment-of-social-cognition-in-comparative-studies-of-patients-with-schizophrenia-and-their-healthy-siblings
#24
REVIEW
Rafał Łoś, Aleksandra Gajowiec
Social cognition impairment is a significant neurocognitive disturbance observed during clinical course of schizophrenia. Deficits in this field observed in first- degree unaffected relatives have been suggested as a potential endophenotype. The main purpose of this study was to review the range of published articles on this topic, mainly from the last decade (2010-2021). A search in the online databases PubMed, Medline and Polish Medical Library using following keywords: schizophrenia, healthy sibling, social cognition, theory of mind, facial emotion recognition...
October 31, 2023: Psychiatria Polska
https://read.qxmd.com/read/38339807/association-of-non-essential-metals-with-chinese-schizophrenia-a-case-control-study
#25
JOURNAL ARTICLE
Jiale Li, Jiewen Chen, Bing Shen, Rumei Lu, Wanting He, Xiaolan Huang, Dongmei Li, Li Su, Jianxiong Long
BACKGROUND: The potential link between environmental pollutants, including metals, and schizophrenia development remains debated. This study aimed to explore the association between plasma levels of three non-essential metals-barium (Ba), tungsten (W), and uranium (U)-and schizophrenia risk among Chinese individuals. METHOD: We recruited a total of 221 patients and 219 healthy controls. Plasma levels of three non-essential metals were measured using inductively coupled plasma mass spectrometry...
February 9, 2024: Early Intervention in Psychiatry
https://read.qxmd.com/read/38326654/immediate-and-delayed-effects-of-environmental-temperature-on-schizophrenia-admissions-in-liuzhou-china-2013-2020-a-time-series-analysis
#26
JOURNAL ARTICLE
Qian Zhou, Xiaolan Huang, Li Su, Xianyan Tang, Yanli Qin, Yuting Huo, Chun Zhou, Jun Lan, Yue Zhao, Zaifei Huang, Guoguang Huang, Yuhua Wei
This study aimed to investigate the associations between environmental temperature and schizophrenia admissions in Liuzhou, China. A Poisson generalized linear model combined with a distributed lag nonlinear model was used to analyze the effects of daily mean temperature on schizophrenia admissions from 2013 to 2020 in Liuzhou. Additionally, subgroup analyses were conducted to investigate possible modifications stratified by gender, marital status, and age. In this study, 10,420 schizophrenia admissions were included...
February 7, 2024: International Journal of Biometeorology
https://read.qxmd.com/read/38308143/hair-cortisol-concentrations-in-pregnant-women-with-bipolar-depressive-or-schizophrenic-spectrum-disorders
#27
JOURNAL ARTICLE
Maja Nyström-Hansen, Marianne Skovsager Andersen, Kirstine Agnete Davidsen, Katrine Roehder, Christopher Trier, Emilie Nayberg, Karlen Lyons-Ruth, Susanne Harder
PURPOSE: Maternal cortisol levels in pregnancy may support the growth of or adversely affect fetal organs, including the brain. While moderate cortisol levels are essential for fetal development, excessive or prolonged elevations may have negative health consequences for both the mother and the offspring. Little is known about predictors of altered hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy. This study examined maternal hair cortisol concentration (HCC) in the 3rd trimester of pregnancy in relation to severe psychopathology...
February 3, 2024: Archives of Women's Mental Health
https://read.qxmd.com/read/38288683/de-novo-variants-in-sp9-cause-a-novel-form-of-interneuronopathy-characterized-by-intellectual-disability-autism-spectrum-disorder-and-epilepsy-with-variable-expressivity
#28
JOURNAL ARTICLE
Marine Tessarech, Gaëlle Friocourt, Florent Marguet, Maryline Lecointre, Morgane Le Mao, Rodrigo Muñoz Díaz, Cyril Mignot, Boris Keren, Bénédicte Héron, Charlotte De Bie, Koen Van Gassen, Didier Loisel, Benoit Delorme, Steffen Syrbe, Annick Klabunde-Cherwon, Rami Abou Jamra, Meret Wegler, Bert Callewaert, Annelies Dheedene, Merzouka Zidannes-Marinnes, Agnès Guichet, Céline Bris, Patrick Van Bogaert, Florence Biquard, Guy Lenaers, Pascale Marcorelles, Claude Ferec, Bruno Gonzalez, Vincent Procaccio, Antonio Vitobello, Dominique Bonneau, Annie Laquerriere, Salim Khiati, Estelle Colin
PURPOSE: Interneuronopathies are a group of neurodevelopmental disorders characterized by deficient migration and differentiation of GABAergic interneurons resulting in a broad clinical spectrum, including autism spectrum disorders, early-onset epileptic encephalopathy, intellectual disability, and schizophrenic disorders. SP9 is a transcription factor belonging to the Krüppel-like factor and specificity protein family, the members of which harbor highly conserved DNA binding domains...
January 27, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38246250/sensory-attenuation-deficit-and-auditory-hallucinations-in-schizophrenia-a-causal-mechanism-or-a-risk-factor-evidence-from-meta-analyses-on-n1-erp-eeg-component
#29
JOURNAL ARTICLE
Marika Mariano, Ileana Rossetti, Angelo Maravita, Eraldo Paulesu, Laura Zapparoli
BACKGROUND: Sensory attenuation (SA), the dampened perception of self-generated sensory information, is typically associated with reduced ERP signals, like for the N1 component of auditory ERPs. SA, together with efficient monitoring of intentions and actions, should facilitate the distinction between self-generated and externally-generated sensory events, optimizing the interaction with the world. According to many, SA is deficient in schizophrenia. The question arises whether altered SA reflects a sufficient mechanism to explain positive symptoms like auditory hallucinations...
January 19, 2024: Biological Psychiatry
https://read.qxmd.com/read/38196922/does-cannabis-affect-cognitive-functioning-in-patients-with-schizophrenia
#30
JOURNAL ARTICLE
Hajar Rachid, Zineb Saif, Salma Raoui, Zineb Serhier, Mohamed Agoub
INTRODUCTION: Cannabis use impairs cognitive performance in healthy subjects; several studies have shown improved cognitive outcomes in schizophrenic patients using cannabis. The aim of this study was to evaluate the effects of cannabis use on cognitive function in Moroccan patients with schizophrenia who were cannabis users. METHOD: Two groups were recruited in a Moroccan University Psychiatric Centre. Fifty patients diagnosed with schizophrenia according to the DSM-V who were cannabis users (SZ CANN +) and forty-nine patients diagnosed with schizophrenia according to DSM-V who do not use cannabis (SZ CANN-)...
June 2024: Schizophrenia Research. Cognition
https://read.qxmd.com/read/38185075/relationship-between-c-reactive-protein-and-antipsychotics-levels-in-schizophrenic-patients-infected-with-covid-19
#31
JOURNAL ARTICLE
Shujuan Pan, Wei Li, Li Shi, Yanli Li, Xiaoyu Wang, Yangfang Zhou, Yaxue Wu, Jingxu Chen, Menghan Lv, Yonggang Li, Xingjie Yang, Xiaoyu Zhu, Yong Zhang, Ting Yu, Junchao Huang, Kebing Yang, Yunlong Tan
In the context of the COVID-19, inflammation emerges as a prominent characteristic. C-reactive protein (CRP) serves as a commonly employed marker for the evaluation of inflammation. This study aimed to examine the correlation between CRP levels and antipsychotic drug concentrations in patients diagnosed with SCZ during the COVID-19 pandemic. A total of 186 SCZ patients were included in this study, which utilized electronic medical records. The collected data encompassed SCZ diagnoses based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, respiratory symptoms, and treatments...
February 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38174682/working-memory-deficit-in-schizophrenia-a-systematic-review-and-meta-analysis-of-fmri-studies-examining-frontal-and-parietal-brain-activity
#32
JOURNAL ARTICLE
Xueying Ding, Hongyang Fu, Liyuan Luo, Jun Wu
INTRODUCTION: The role of functional magnetic resonance imaging (fMRI) findings in investigation of working memory (WM) deficit in schizophrenia patients is still debatable. The aim of the study was to investigate the role of fMRI findings of the frontal and parietal brain activity in investigation of WM deficit in schizophrenia patients. MATERIAL AND METHODS: We used Medline, Embase, and the Cochrane Database to conduct a comprehensive search up to January 2023...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38172146/establishing-associated-risk-factors-including-fungal-and-parasitic-infections-among-malaysians-living-with-schizophrenia
#33
JOURNAL ARTICLE
Freddy Franklin, Arutchelvan Rajamanikam, Wei Kit Phang, Chandramathi Samudi Raju, Jesjeet Singh Gill, Benedict Francis, Luke Sy-Cherng Woon, Suresh Kumar Govind
The aetiology of schizophrenia is multifactorial, and the identification of its risk factors are scarce and highly variable. A cross-sectional study was conducted to investigate the risk factors associated with schizophrenia among Malaysian sub-population. A total of 120 individuals diagnosed with schizophrenia (SZ) and 180 non-schizophrenic (NS) individuals participated in a questionnaire-based survey. Data of complete questionnaire responses obtained from 91 SZ and 120 NS participants were used in statistical analyses...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38139760/biopsychosocial-variables-in-male-schizophrenic-patients-a-comprehensive-comparison-with-healthy-controls
#34
JOURNAL ARTICLE
Krzysztof Krysta, Beata Trędzbor, Ewa Martyniak, Aleksandra Cieślik, Agnieszka Koźmin-Burzyńska, Katarzyna Piekarska-Bugiel, Katarzyna Skałacka, Rafał Bieś, Marek Krzystanek
OBJECTIVE: this study aims to comprehensively compare neuropsychological, psychopathological, anthropometric, biochemical, pharmacological, and lifestyle variables between 27 male schizophrenic patients (SZ group) and 30 age- and sex-matched healthy male controls (HC group). METHODS: participants underwent a battery of neuropsychological tests including the Trail Making Test (TMT), Stroop Color-Word Interference Test, and Verbal Fluency Test. Psychopathological symptoms in the SZ group were evaluated using the Positive and Negative Syndrome Scale (PANSS)...
November 21, 2023: Pharmaceuticals
https://read.qxmd.com/read/38137335/cognition-in-patients-with-schizophrenia-interplay-between-working-memory-disorganized-symptoms-dissociation-and-the-onset-and-duration-of-psychosis-as-well-as-resistance-to-treatment
#35
JOURNAL ARTICLE
Georgi Panov, Silvana Dyulgerova, Presyana Panova
UNLABELLED: Schizophrenia is traditionally associated with the presence of psychotic symptoms. In addition to these, cognitive symptoms precede them and are present during the entire course of the schizophrenia process. The present study aims to establish the relationship between working memory (short-term memory and attention), the features of the clinical picture, and the course of the schizophrenic process, gender distribution and resistance to treatment. METHODS: In total, 105 patients with schizophrenia were observed...
November 22, 2023: Biomedicines
https://read.qxmd.com/read/38127696/-experience-of-clinical-use-of-fluvoxamine-for-the-treatment-of-comorbid-depression-in-childhood-and-adolescence
#36
JOURNAL ARTICLE
A V Goryunov, N I Golubeva, O V Shushpanova
OBJECTIVE: To identify the frequency of administration of fluvoxamine, to determine the main targets of the drug and the expediency of its use in depression of various genesis in children and adolescents. MATERIAL AND METHODS: To assess the frequency of prescribing fluvoxamine, 195 medical histories of patients who were inpatients in the children's department of the Mental Health Research Center in 2023 were analyzed. To assess the dynamics of depression during treatment with fluvoxamine, a clinical group was formed of 12 patients aged 10 to 15 years (age 13...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38106620/a-37-year-old-schizophrenic-woman-with-abdominal-pain
#37
Yiqun Liao, Yue Ma, Fei Chao, Yong Wang, Ziming Zhao, Jun Ren
INTRODUCTION: Internal fistula across the posterior wall of stomach and the transverse colon caused by foreign bodies in the alimentary tract presents an extremely rare medical entity. PRESENTATION OF CASE: We report an aschizophrenia female patient with onset of internal fistula across the posterior wall of stomach and the transverse colon triggered by swallowed magnetic metal beads. The patient was admitted to the emergency room of Northern Jiangsu People's Hospital because of acute right lower abdominal pain...
2023: Clinical Medicine Insights. Case Reports
https://read.qxmd.com/read/38098922/recurrent-transient-hypoxemia-in-a-schizophrenic-patient-caused-by-upper-airway-foreign-body-obstruction-by-watermelon
#38
Kaori Amari, Risa Hirata, Masaki Tago
A woman in her 70s with schizophrenia experienced repeated episodes of limb tremors and hypoxemia. Even after admission, the same symptoms continued while in a supine position. However, her condition rapidly improved with bag valve mask ventilation. Although computed tomography suggested aspiration pneumonia, she had a strong cough reflex while performing bronchoscopy, and no residues were observed in the trachea. Following the bronchoscopy examination, the patient was prompted by a nurse and subsequently expelled a mass of watermelon from her oral cavity, which was identified as a watermelon eaten during breakfast on the day...
November 2023: Curēus
https://read.qxmd.com/read/38083832/psychiatric-disorders-and-management-of-sexual-offenders-in-the-prison-psychiatric-consultation-unit-of-marseille
#39
JOURNAL ARTICLE
Noémie Bernardi, Clémence Delteil, Éric Kania, Pascale Giravalli, Lucile Tuchtan, Jean-Pierre Guay, Marie-Dominique Piercecchi, Christophe Bartoli, Jokthan Guivarch
Since 2017, complaints of sexual violence have increased in France. At the same time, the management of sexual offenders has been at the center of international public health policies. The prevalence of mental disorders among sexual offenders is an essential field of research. There are some published studies on the prevalence of psychiatric disorders in sexual offenders in detention, but there are few recent published studies among French individuals who were detained. Our objectives were to determine the prevalence of psychiatric disorders among persons detained for sexual offenses and the level of care received according to their diagnosis...
December 11, 2023: Journal of Forensic Sciences
https://read.qxmd.com/read/38079053/hfd-exacerbated-metabolic-side-effects-of-olanzapine-are-suppressed-by-er-stress-inhibitor
#40
JOURNAL ARTICLE
Yu-Feng Zuo, Bao-Hua Zhang, Ming-Rui Guo, Ben-Ben Li, Bao-Cui Wang, Deng Duan, Yu-Xin Wang, Jing Xi, Meng He, Tao-Lei Sun
OBJECTIVE: Numerous schizophrenic patients are suffering from obesity primarily attributed to antipsychotic medication and poor dietary habits. This study investigated the progressive deterioration of olanzapine-induced metabolic disorders in the presence of a high-fat diet (HFD) and explored the involvement of endoplasmic reticulum (ER) stress. METHODS: Female Sprague-Dawley rats fed on a standard chow diet or HFD were treated with olanzapine (3 mg/kg/day) and the ER stress inhibitor 4-phenylbutyric acid (4-PBA, 1 and 0...
December 11, 2023: Current Medical Science
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