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Schizophrenic

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https://www.readbyqxmd.com/read/28937620/dysbindin-1-involvement-in-the-etiology-of-schizophrenia
#1
REVIEW
Haitao Wang, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success on cognitive impairment and long-term disability and are burdened by side effects. Although new antipsychotic medications have been launched in the past decades, there has been a general lack of significant innovation. This lack of significant progress in the pharmacotherapy of schizophrenia is a reflection of the complexity and heterogeneity of the disease...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28936815/-current-clinical-variables-in-schizophrenia-cases-with-suicide-attempt-history
#2
Demet Sağlam Aykut, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Serdar Karakullukçu, Ahmet Tiryaki
OBJECTIVE: High suicide risk was shown to be related with depression and low quality of life in studies investigating clinical variables related to suicidal behavior. The aim of this study was to investigate the effects of a suicide attempt on clinical presentation by comparing sociodemographic variables, clinical signs, symptoms of depression, quality of life, social functionality, and reported adverse drug reactions in schizophrenic patients with and without suicide. METHOD: Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale (CDS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social Functioning Scale (SFS), and Udvalg for Kliniske Undersøgelser Side Effect Rating Scale (UKU) were administered to 115 patients with schizophrenia...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936154/potential-role-of-amino-acids-in-pathogenesis-of-schizophrenia
#3
REVIEW
Shamaila Saleem, Faiza Shaukat, Anjuman Gul, Mahwish Arooj, Arif Malik
Schizophrenia is a syndrome of inconclusive etiopathogenesis with a prevalence of about 1% in general population. Underlying factors include genetic predisposition and defected neurodevelopment in early stages of life. The role of amino acids has been indicated in some reports. However, very few workers have detailed the effect of each amino acid in the pathophysiology of schizophrenia. Thus, in the present review, we aimed to provide an insight into the potential role of amino acids levels during schizophrenia...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28927969/comparison-of-metabolic-syndrome-prevalence-in-patients-with-schizophrenia-and-bipolar-i-disorder
#4
Razieh Nayerifard, Majid Akbari Bureng, Alireza Zahiroddin, Massood Namjoo, Sepideh Rajezi
Research has shown that the metabolic syndrome is more prevalent among patients with schizophrenia or bipolar I disorder. Given the scarcity of research on the disorders, this paper aims to compare the prevalence of the syndrome among the two groups of patients. METHODS: A total of 120 individuals participated in this cross sectional study: 60 patients with schizophrenia (26 males and 34 females) and 60 patients with bipolar I disorder (32 males and 28 females). The psychological disorders were diagnosed by some experienced psychiatrists according to the DSM-V...
May 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28924878/differences-between-schizophrenic-and-normal-subjects-using-network-properties-from-fmri
#5
Youngoh Bae, Kunaraj Kumarasamy, Issa M Ali, Panagiotis Korfiatis, Zeynettin Akkus, Bradley J Erickson
Schizophrenia has been proposed to result from impairment of functional connectivity. We aimed to use machine learning to distinguish schizophrenic subjects from normal controls using a publicly available functional MRI (fMRI) data set. Global and local parameters of functional connectivity were extracted for classification. We found decreased global and local network connectivity in subjects with schizophrenia, particularly in the anterior right cingulate cortex, the superior right temporal region, and the inferior left parietal region as compared to healthy subjects...
September 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28919723/effect-of-caregivers-expressed-emotion-on-the-care-burden-and-rehospitalization-rate-of-schizophrenia
#6
Xia Wang, Qiongni Chen, Min Yang
BACKGROUND: This study assessed the effect of expressed emotion (EE) among caregivers of schizophrenia patients on their care burden and the illness rehospitalization rate. SUBJECTS AND METHODS: A total of 64 schizophrenia patients hospitalized for the first time and their key caregivers were recruited. The Chinese version of the Camberwell Family Interview (CFI-CV) was used to evaluate the EE of the key caregivers. A family burden questionnaire was used to evaluate the care burden...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28913970/human-neutrophils-show-decreased-survival-upon-long-term-exposure-to-clozapine
#7
Aya Goto, Akira Yoshimi, Tomoko Nagai, Mako Ukigai, Akihiro Mouri, Norio Ozaki, Yukihiro Noda
OBJECTIVE: Clozapine is an atypical antipsychotic prescribed for treatment-resistant schizophrenic patients, but treatment with clozapine is strictly limited because it can induce lethal-hematologic side effects. We investigated the effects of short- and long-term exposure of human neutrophils derived from healthy subjects to clozapine and compared them with the effects of reactive metabolite of clozapine, olanzapine, and doxorubicin. METHODS: Neutrophils were exposed to clozapine and olanzapine (1, 10, 50, or 100 μM), reactive metabolite of clozapine (50 or 100 μM), or doxorubicin (0...
September 15, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28882471/arginine-vasopressin-improves-the-memory-deficits-in-han-chinese-patients-with-first-episode-schizophrenia
#8
Cai-Hong Geng, Chao Wang, Jun Yang, Hua Wang, Rui-Qing Ma, Xu Liu, Chang-Hong Wang
The memory impairment is a core deficit in the first-episode schizophrenia patients. Arginine vasopressin (AVP) in the brain can improve learning and memory. We performed multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial to study the cognitive functioning in Han Chinese first-episode schizophrenic patients in a 12-week treatment regime with the intranasal administration of AVP (128 cases) or placebo (131 cases) in addition to the conventional treatment. The methods of positive and negative syndrome scale (PANSS), Wechsler memory scale-4th edition (WMS-IV) and event-related potential (ERP) were used to study the effects of AVP on the cognitive function...
September 4, 2017: Peptides
https://www.readbyqxmd.com/read/28882081/assessment-of-time-management-skills-psychometric-properties-of-the-swedish-version
#9
Gunnel Kristina Janeslätt, Kajsa Lidström Holmqvist, Suzanne White, Marie Holmefur
BACKGROUND: Persons with impaired time management skills are often in need of occupational therapy. Valid and reliable instruments to assess time management and organizational skills are needed for the evaluation of intervention. The purpose of this study was to evaluate the psychometric properties of a Swedish version of the Assessment of Time Management Skills (ATMS-S) for persons with and without impaired time management skills. METHOD: A total of 238 persons participated in the study, of whom 94 had self-reported impaired time management skills due to mental disorders such as schizophrenic spectrum or neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and mild intellectual disabilities, and 144 persons had no reported impaired time management skills...
September 7, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28881851/the-involvement-of-darpp-32-in-the-pathophysiology-of-schizophrenia
#10
REVIEW
Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
Schizophrenia is one of the most devastating heterogeneous psychiatric disorders. The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia based on neurochemical evidences of elevated brain striatal dopamine synthesis capacity and increased dopamine release in response to stress. Dopamine and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000 (DARPP-32) is a cytosolic protein highly enriched in the medium spiny neurons of the neostriatum, considered as the most important integrator between the cortical input and the basal ganglia, and associated with motor control...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881360/-is-the-theoretical-support-for-the-improvement-of-brain-plasiticity-in-schizophrenic-psychoses-adequate
#11
Peter Falkai
No abstract text is available yet for this article.
September 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28876084/trifluoperazine-activates-foxo1-related-signals-to-inhibit-tumor-growth-in-hepatocellular-carcinoma
#12
Jingwen Jiang, Zhongxi Huang, Xuewu Chen, Rongcheng Luo, Hongbin Cai, Hairu Wang, Hui Zhang, Tao Sun, Yunfang Zhang
Schizophrenic patients tend to have reduced incidence of some cancers due to the treatment of antipsychotic drugs with antitumor effects, such as chlorpromazine and trifluoperazine (TFP). Forkhead Box O1 (FOXO1) as tumor suppressor in many malignancies is often inactivated by nuclear export, which could be inhibited by TFP. However, the antitumor efficiency of TFP and related role of FOXO1 in hepatocellular carcinoma (HCC) are unclear. Thus, two HCC cell lines SMMC-7721 and Bel-7402 were treated with different concentrations of TFP and the IC50 was determined...
September 6, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28875514/cancer-screening-participation-in-schizophrenic-outpatients-and-the-influence-of-their-functional-disability-on-the-screening-rate-a-cross-sectional-study-in-japan
#13
Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada
AIM: The influence of schizophrenic patients' functional disability on cancer screening participation worldwide is unclear. There are few findings on the disparities in schizophrenic patients' participation in cancer screening programs in Asia. The aim of this study was to investigate the screening rate and the associations between screening and symptom severity/functional disability in patients with schizophrenia. METHODS: This cross-sectional study was conducted in a psychiatric hospital outpatient clinic in Japan...
September 5, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28872562/gpx1-pro198leu-polymorphism-and-gstp1-ile105val-polymorphisms-are-not-associated-with-the-risk-of-schizophrenia-in-the-chinese-han-population
#14
Huijie Gao, Chao Liu, Sijia Song, Chuanqiang Zhang, Qun Ma, Xiao Li, Luo Xu
Increasing lines of evidence show that oxidative stress plays a role in the pathophysiological mechanisms of schizophrenia (SCZ). Polymorphic variants of oxidative stress-related candidate genes GPX1 and GST1 can affect the antioxidant activities of their encoded enzymes. Therefore, this study aimed to explore the association between the single nucleotide polymorphisms (SNPs) of GPX1 and GSTP1 and susceptibility to schizophrenia in the Chinese Han population. DNA from 323 healthy controls and 210 schizophrenic patients was genotyped for SNPs rs1050450 in GPX1 and rs1695 in GSTP1 using a predesigned TaqMan SNP genotyping assay...
September 1, 2017: Neuroreport
https://www.readbyqxmd.com/read/28870686/-risk-factors-related-to-homicide-in-moroccan-patients-with-schizophrenia
#15
A Kachouchi, M Sebbani, S Salim, I Adali, F Manoudi, M Amine, F Asri
BACKGROUND: Persons with schizophrenia are thought to be at increased risk of committing violent crime - 4 to 6 times the level of general population individuals without this disorder. The relationship between schizophrenia and homicide is complex and cannot be reduced to a simple causal link. OBJECTIVES: The objectives of this study were to describe the characteristics of homicide in Moroccan patients suffering from schizophrenia and to determine the correlated sociodemographic, clinical and toxic variables...
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28867829/ph-responsive-schizophrenic-diblock-copolymers-prepared-by-polymerization-induced-self-assembly
#16
Sarah L Canning, Thomas J Neal, Steven P Armes
Polymerization-induced self-assembly (PISA) is used for the highly convenient and efficient preparation of ampholytic diblock copolymer nanoparticles directly in acidic aqueous solution. Cationic nanoparticles comprising a protonated polyamine stabilizer block and a hydrophobic polyacid core-forming block are formed at pH 2. Micelle inversion occurs at pH 10 to produce anionic nanoparticles with an ionized polyacid stabilizer block and a hydrophobic polyamine core-forming block. Macroscopic precipitation occurs at around pH 6-7, which lies close to the isoelectric point of this ampholytic diblock copolymer...
August 22, 2017: Macromolecules
https://www.readbyqxmd.com/read/28867194/identification-of-an-argpyrimidine-modified-protein-in-human-red-blood-cells-from-schizophrenic-patients-a-possible-biomarker-for-diseases-involving-carbonyl-stress
#17
Y I Ishida, T Kayama, Y Kibune, S Nishimoto, S Koike, T Suzuki, Y Horiuchi, M Miyashita, M Itokawa, M Arai, Y Ogasawara
Argpyrimidine (ARP) is an advanced glycation end product thought to be generated from a reaction between methylglyoxal and arginine residues in proteins. In this study, we observed marked accumulation of an approximately 56 kD protein, reactive to anti-ARP antibodies, in the red blood cells (RBCs) of some patients with refractory schizophrenia. This ARP-modified protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS. This is the first report of ARP-modified proteins accumulating in RBCs of patients with diseases involving carbonyl stress...
August 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28863391/a-precision-medicine-approach-for-psychiatric-disease-based-on-repeated-symptom-scores
#18
Anthony T Fojo, Katherine L Musliner, Peter P Zandi, Scott L Zeger
For psychiatric diseases, rich information exists in the serial measurement of mental health symptom scores. We present a precision medicine framework for using the trajectories of multiple symptoms to make personalized predictions about future symptoms and related psychiatric events. Our approach fits a Bayesian hierarchical model that estimates a population-average trajectory for all symptoms and individual deviations from the average trajectory, then fits a second model that uses individual symptom trajectories to estimate the risk of experiencing an event...
August 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28844295/concentrations-in-plasma-clozapine-levels-in-schizophrenic-and-schizoaffective-patients
#19
Celso Iglesias García, Ana Iglesias Alonso, Julio Bobes
INTRODUCTION: There is great variability in plasma levels of clozapine. The objective of this study is to know the characteristics of patients treated with clozapine and the relationship between them and the variability of plasma levels. MATERIAL AND METHODS: Descriptive, cross-sectional study of all patients currently treated with clozapine in a Psychiatric Service with a diagnosis of schizophrenic psychosis or schizoaffective disorder. The present study assessed physical situation, psychopathology and functionality of the patients and explored the associations and correlations between clinical variables and plasma levels...
August 22, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28843131/left-hemispheric-breakdown-of-ltp-like-cortico-cortical-plasticity-in-schizophrenic-patients
#20
Michele Ribolsi, Giulia Lisi, Viviana Ponzo, Alberto Siracusano, Carlo Caltagirone, Cinzia Niolu, Giacomo Koch
OBJECTIVE: Altered cortical connectivity and plasticity seems to be asymmetrical between the hemispheres in patients with schizophrenia (SCZ). We evaluated long-term potentiation (LTP) in parietal-frontal circuits of both hemispheres using a cortico-cortical Paired Associative Stimulation (cc-PAS) protocol testing the rules of Hebbian-like spike timing dependent plasticity (SPTD). METHODS: 12 SCZ and 12 healthy subjects (HS) underwent a cc-PAS protocol to activate, by means of paired pulses of transcranial magnetic stimulation (TMS), the short-latency connection between posterior parietal cortex (PPC) and primary motor cortex (M1) of both hemispheres...
July 14, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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