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https://www.readbyqxmd.com/read/28529354/metamorphosis-a-reason-why-many-chronic-schizophrenics-get-abandoned-by-their-dear-ones
#1
EDITORIAL
James T Antony
No abstract text is available yet for this article.
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28526279/an-emerging-role-for-mitochondrial-dynamics-in-schizophrenia
#2
REVIEW
Kyle H Flippo, Stefan Strack
Abnormal brain development has long been thought to contribute to the pathophysiology of schizophrenia. Impaired dendritic arborization, synaptogenesis, and long term potentiation and memory have been demonstrated in animal models of schizophrenia. In addition to aberrant nervous system development, altered brain metabolism and mitochondrial function has long been observed in schizophrenic patients. Single nucleotide polymorphisms in the mitochondrial genome as well as impaired mitochondrial function have both been associated with increased risk for developing schizophrenia...
May 16, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28515915/superior-effects-of-quetiapine-compared-with-aripiprazole-and-iloperidone-on-mk-801-induced-olfactory-memory-impairment-in-female-mice
#3
Ahmet Mutlu, Oguz Mutlu, Guner Ulak, Furuzan Akar, Havva Kaya, Faruk Erden, Pelin Tanyeri
Cognitive dysfunction is commonly observed in schizophrenic patients and the administration of antipsychotic treatments results in different outcomes. Although the typical antipsychotic treatments, such as haloperidol, appear to be unable to improve cognition dysfunction, the atypical antipsychotic drugs (quetiapine, aripiprazole and iloperidone) exert a beneficial effect. The purpose of the current study was to investigate the effects of atypical antipsychotics on olfactory memory in mice, utilizing the social transmission of food preference (STFP) tests to evaluate the effects of drugs on MK-801-induced cognitive dysfunction...
May 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28515552/the-influence-of-psychosocial-dysfunctions-in-chronic-schizophrenia-patients-in-remission-a-hospital-based-study
#4
Sarada Prasanna Swain, Sushree Sangita Behura, Manoj Kumar Dash, Anil Kumar Nayak, Saswati Sucharita Pati
BACKGROUND: Psychosocial dysfunctions in the various psychosocial areas in chronic schizophrenic patients predict the long-term course, outcome, and quality of life of these patients, which always varies with years of treatment. OBJECTIVE: To know the influence and compare the level of psychosocial dysfunctions and severity of disability burden in chronic schizophrenic patients who are in remission with duration of 5 and 20 years. MATERIALS AND METHODS: The sample was collected from the OPD of Mental Health Institute (COE), S...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28513779/the-preventive-effects-of-ascorbic-acid-supplementation-on-locomotor-and-acetylcholinesterase-activity-in-an-animal-model-of-schizophrenia-induced-by-ketamine
#5
Louyse S Damazio, Flávia R Silveira, Lara Canever, Adalberto A DE Castro, Jadne M Estrela, Josiane Budni, Alexandra I Zugno
Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i...
May 15, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28507309/pick1-genetic-variation-and-cognitive-function-in-patients-with-schizophrenia
#6
Yi-Ting Chen, Chieh-Hsin Lin, Chiung-Hsien Huang, Wen-Miin Liang, Hsien-Yuan Lane
The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorphisms of PICK1 (rs2076369, rs3952) affected cognitive functions in schizophrenic patients. We analyzed 302 patients and tested the differences of cognitive functions, clinical symptoms between genetic groups. We also used general linear model to analyze the effect of PICK1 genetic polymorphisms on cognitive functions...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28498089/changes-in-bmi-in-hospitalized-patients-during-treatment-with-antipsychotics-depending-on-gender-and-other-factors
#7
Lenka Sušilová, Eva Češková, David Hampel, Aleš Sušil, Jan Šimůnek
OBJECTIVE: To investigate the differences in body mass index (BMI) changes between men and women during hospitalization. METHODS: The retrospective study monitored demographic and clinical data of 462 schizophrenic patients hospitalized 737 times between 2006 and 2011. BMI analysis was performed on patients on antipsychotic medication hospitalized longer than four days. RESULTS: Patients with an initial BMI < 25 gained more weight than patients with a BMI > 25 (3...
February 24, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28497736/-implication-of-human-endogenous-retroviruses-in-schizophrenia-and-bipolar-disorder
#8
Pierre Ellul, Laurent Groc, Marion Leboyer
Schizophrenia and bipolar disorder are neuropsychiatric disorders of unknown origin. It seems that these two disorders share some common etiopathogenic mechanisms including genetic, environmental and inflammatory ones. Reactivation of the human endogenous retrovirus type W (HERV-W) can be a shared element in the pathophysiology of schizophrenia and bipolar disorder, linked to immuno-genetic and environment risk factors. We will present studies that have highlighted the presence of HERV-W in schizophrenic and bipolar disorder patients...
April 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28493003/bio-shielding-in-situ-forming-gels-bsifg-loaded-with-lipospheres-for-depot-injection-of-quetiapine-fumarate-in-vitro-and-in-vivo-evaluation
#9
Mustafa M Abo Elela, Nermeen A ElKasabgy, Emad B Basalious
Quetiapine fumarate (QF), an anti-schizophrenic drug, suffers from rapid elimination and poor bioavailability due to extensive first-pass effect. Intramuscularly (IM) injected lipospheres were designed to enhance the drug's bioavailability and extend its release. A central composite design was applied to optimize the liposphere preparation by a melt dispersion technique using Compritol® 888 ATO or glyceryl tristearate as lipid component and polyvinyl alcohol as surfactant. Lipospheres were evaluated for their particle size, entrapment efficiency, and in vitro release...
May 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28489133/association-between-antipsychotics-and-cardiovascular-adverse-events-a-systematic-review
#10
Ana Amancio Santos Da Silva, Marina Viegas Moura Rezende Ribeiro, Célio Fernando de Sousa-Rodrigues, Fabiano Timbó Barbosa
Objective: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents. Method: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies, three cohort original articles were selected for quality analysis. Results: 403,083 patients with schizophrenia and 119,015 participants in the control group data were analyzed...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28487497/the-involvement-of-darpp-32-in-the-pathophysiology-of-schizophrenia
#11
REVIEW
Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
Schizophrenia is one of the most devastating heterogeneous psychiatric disorders. The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia based on neurochemical evidences of elevated brain striatal dopamine synthesis capacity and increased dopamine release in response to stress. Dopamine and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000 (DARPP-32) is a cytosolic protein highly enriched in the medium spiny neurons of the neostriatum, considered as the most important integrator between the cortical input and the basal ganglia, and associated with motor control...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28485733/maternal-immune-activation-results-in-complex-microglial-transcriptome-signature-in-the-adult-offspring-that-is-reversed-by-minocycline-treatment
#12
D Mattei, A Ivanov, C Ferrai, P Jordan, D Guneykaya, A Buonfiglioli, W Schaafsma, P Przanowski, W Deuther-Conrad, P Brust, S Hesse, M Patt, O Sabri, T L Ross, B J L Eggen, E W G M Boddeke, B Kaminska, D Beule, A Pombo, H Kettenmann, S A Wolf
Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of developing psychiatric pathologies in later life. This link may be bridged by a defective microglial phenotype in the offspring induced by MIA, as microglia have key roles in the development and maintenance of neuronal signaling in the central nervous system. The beneficial effects of the immunomodulatory treatment with minocycline on schizophrenic patients are consistent with this hypothesis. Using the MIA mouse model, we found an altered microglial transcriptome and phagocytic function in the adult offspring accompanied by behavioral abnormalities...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28483174/-impact-of-a-multimodal-intervention-on-the-psychological-profile-of-schizophrenic-and-bipolar-i-patients-a-study-of-prisma-program
#13
Ana María Díaz-Zuluaga, Cristian Vargas, Kelly Duica, Shanel Richard, Juan David Palacio, Yuli Agudelo Berruecos, Sigifredo Ospina, Carlos López-Jaramillo
BACKGROUND: Bipolar Disorder (BD) and schizophrenia are included in the group of severe mental illness and are main causes of disability and morbidity in the local population due to the bio-psycho-social implications in patients. In the last 20 years or so, adjunctive psychological interventions been studied with the purpose of decreasing recurrences, stabilising the course of the disease, and improving the functionality in these patients. OBJECTIVE: To analyse the psychological effect of a multimodal intervention (MI) vs a traditional intervention (TI) program in BD I and schizophrenic patients...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28480861/development-of-the-g-c-m-s-m-s-method-for-qualitative-and-quantitative-determination-of-clozapine-in-human-blood
#14
K Sivsivadze, M Jokhadze, P Tushurashvili, T Murtazashvili, N Imnadze
A simple, rapid, selective, sensitive gas chromatography-mass spectrometry (GC-MS/MS) method was developed and validated for the determination of clozapine in human blood. For isolation was used solid phase extraction. The calibration standards range was 5-1500ng/mL. Analysis was carried out on a gas chromatograph Agilent 7000A Quadrupole GC-MS/MS. GC run conditions - capillary column HP-5MS, 30m × 0.25mm, coated with a 0.25μm film, column temperature from 50°C to 305°C with an increase of 10°C/min; the injection port and the transfer line temperature were 310°C; carrier gas - helium at flow rate of 1...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28461252/cortisol-in-schizophrenia-no-association-with-tobacco-smoking-clinical-symptoms-or-antipsychotic-medication
#15
Gordana Nedic Erjavec, Suzana Uzun, Matea Nikolac Perkovic, Oliver Kozumplik, Dubravka Svob Strac, Ninoslav Mimica, Mika Hirasawa-Fujita, Edward F Domino, Nela Pivac
Cigarette smoking is associated with higher cortisol levels in healthy subjects. In schizophrenia this relationship is not clear. There are divergent results on the association between cortisol with smoking, clinical symptoms and medication in schizophrenia. This study evaluated this association in 196 Caucasian inpatients with schizophrenia (51.30±26.68years old), subdivided into 123 smokers and 73 non-smokers. Basal salivary cortisol levels were measured twice, at 08.00 and 09.00AM, 90-120min after awakening...
April 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28444578/experimental-psychosis-research-and-schizophrenia-similarities-and-dissimilarities-in-psychopathology
#16
Leo Hermle, Rainer Kraehenmann
The aim of experimental psychopathology is to delineate overlapping functional disorders of psychoneurobiologically-defined systems where a set of common symptoms may correspond to a variety of nosological entities. According to the vulnerability model of psychosis, experimental research needs to go beyond categories such as "schizophrenia". Prospective studies of the effects of psychoactive substances in normal control subjects offer several methodological advantages over routine clinical reviews of schizophrenic patients, especially in terms of standardization...
April 26, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#17
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28436782/subverting-space-an-exploration-of-a-dance-therapy-workshop-apparatus-for-schizophrenics
#18
Silvia Lippi, Laetitia Petit
The authors created a dance workshop for schizophrenic patients designed to address their singular experience of space, in which the categories of interior and exterior do not function as limits. The space of the workshop, which, paradoxically, is thought in terms of the psychic space of schizophrenic patients by playing on its borderless quality, creates a continuity between the psychiatric hospital and the external world, and thus helps to prevent the segregation and isolation of such patients. This continuity is established on the basis of both the physical architecture of the workshop setting and the practice of dancing itself...
April 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/28429899/neurotransmitter-systems-neuroanatomical-pathology-and-cell-death-in-schizophrenia-update-and-perspectives
#19
Hazael Avila-Rojas, Hugo Sandoval-Zamora, Iván Pérez-Neri
Schizophrenia is a thought disorder characterized by delusional thinking which may be accompanied by hallucinations involving any sensory modality. Schizophrenia may be associated with several neurologic and psychiatric disorders. Also, it may be induced by drugs. In spite of the similarity in psychoses symptomatology, it is unknown if it involves the same underlying neurobiologic mechanisms in those cases. Schizophrenic patients exhibit not only neuroanatomical alterations, but also, distortion of several neurotransmitter systems...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28422427/is-motor-imagery-different-in-catatonic-schizophrenia
#20
Yuliya Zaytseva, Alexandra Morozova, Marie Bendova, Zhanna Garakh
Catatonic schizophrenia, a rare subtype in this disease group, is characterized by motor disturbances. The current study investigated the reactivity of electroencephalographic mu rhythm in a motion imagery task in two single cases of first-episode catatonic schizophrenia, assuming they would show less mu rhythm reduction compared to paranoid schizophrenic patients and healthy controls.
April 19, 2017: PsyCh Journal
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