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https://www.readbyqxmd.com/read/29338548/glycine-transporter-1-inhibitors-a-patent-review-2011-2016
#1
Christopher L Cioffi
Numerous research groups have developed GlyT-1 inhibitors in the pursuit of providing a novel antipsychotic treatment for schizophrenia. Despite multiple compounds advancing into clinical trials, a GlyT-1 inhibitor has yet to emerge to treat patients. However, the approach remains heavily investigated as it presents potential therapeutic utility for several other CNS and non-CNS-related indications. Areas covered: This review discusses various GlyT-1 inhibitor chemotypes identified and provides an overview of patent applications filed and published during the period of 2011-2016...
January 17, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29317600/altered-avalanche-dynamics-in-a-developmental-nmdar-hypofunction-model-of-cognitive-impairment
#2
Saurav Seshadri, Andreas Klaus, Daniel E Winkowski, Patrick O Kanold, Dietmar Plenz
Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29314398/right-treatment-for-the-right-schizophrenic-patients-based-on-carbonyl-stress-pathophysiology
#3
EDITORIAL
Norio Ozaki
No abstract text is available yet for this article.
January 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29313261/enhancement-of-in-vivo-efficacy-and-oral-bioavailability-of-aripiprazole-with-solid-lipid-nanoparticles
#4
Silki, Vivek Ranjan Sinha
Aripiprazole (ARP), a second-generation or atypical antipsychotic, is poorly soluble and undergoes extensive hepatic metabolism and P-glycoprotein efflux which lead to reduced in vivo efficacy and increased dose-related side effects. To enhance in vivo efficacy and oral bioavailability of aripiprazole, aripiprazole-loaded solid lipid nanoparticles (SLNs) were developed using tristearin as solid lipid. Tween 80 and sodium taurocholate were used as surfactants to prepare SLNs using microemulsification method...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29310919/increased-complications-for-schizophrenia-and-bipolar-disorder-patients-undergoing-total-joint-arthroplasty
#5
Michael M Kheir, You Na P Kheir, Timothy L Tan, Colin T Ackerman, Alexander J Rondon, Antonia F Chen
BACKGROUND: Although it has been shown that anxiety and depression are associated with increased complications after total joint arthroplasty (TJA), the outcomes of TJA in patients with a history of psychosis are unknown. This study evaluated the influence of bipolar and schizophrenic disorders on complications after TJA, particularly aseptic and septic revisions. METHODS: A retrospective review of 156 TJAs (125 primaries and 31 revisions) was performed at a single institution from 2000 to 2015...
December 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29310360/achieving-stable-remission-with-maintenance-electroconvulsive-therapy-in-a-patient-with-treatment-resistant-schizophrenia-a-case-report
#6
Sebastian Moeller, Neele Kalkwarf, Caroline Lücke, Diana Ortiz, Sonja Jahn, Christiane Först, Niclas Braun, Alexandra Philipsen, Helge H O Müller
RATIONALE: Up to one third of all schizophrenic patients are classified as having treatment-resistant schizophrenia (TRS). This subgroup faces remarkable medical and psychosocial damages, and pharmacotherapy is often limited due to nonresponse and/or side effects. Maintenance electroconvulsive therapy (M-ECT) might be effective in TRS. PATIENT CONCERNS: We present a case of a 26-year-old male patient with a TRS. DIAGNOSES: He received a treatment series of ECT sessions and a course of 24 M-ECTs...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29309433/association-studies-of-wd-repeat-domain-3-and-chitobiosyldiphosphodolichol-beta-mannosyltransferase-genes-with-schizophrenia-in-a-japanese-population
#7
Momoko Kobayashi, Daisuke Jitoku, Yoshimi Iwayama, Naoki Yamamoto, Tomoko Toyota, Katsuaki Suzuki, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Akeo Kurumaji, Takeo Yoshikawa, Toru Nishikawa
Schizophrenia and schizophrenia-like symptoms induced by the dopamine agonists and N-methyl-D aspartate type glutamate receptor antagonists occur only after the adolescent period. Similarly, animal models of schizophrenia by these drugs are also induced after the critical period around postnatal week three. Based upon the development-dependent onsets of these psychotomimetic effects, by using a DNA microarray technique, we identified the WD repeat domain 3 (WDR3) and chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) genes as novel candidates for schizophrenia-related molecules, whose mRNAs were up-regulated in the adult (postnatal week seven), but not in the infant (postnatal week one) rats by an indirect dopamine agonist, and phencyclidine, an antagonist of the NMDA receptor...
2018: PloS One
https://www.readbyqxmd.com/read/29306989/kynurenine-is-correlated-with-il-1%C3%AE-in-plasma-of-schizophrenia-patients
#8
Helena P G Joaquim, Alana C Costa, Wagner F Gattaz, Leda Leme Talib
The etiology of schizophrenia is still unclear. It is well-known that pro-inflammatory cytokines are higher in schizophrenia patients since the first episode psychosis comparing to healthy controls. Inflammatory downstream cascades influence different cellular pathways, like the displacement of the tryptophan (TRP) metabolism to the production of kynurenine (KYN) instead of serotonin, which results in the generation of several neuro and immunoactive metabolites. The aim of this study was to determine TRP, KYN and IL-1β plasma levels in first-onset schizophrenia (n = 28) and healthy controls (n = 30)...
January 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29297320/automatic-schizophrenic-discrimination-on-fnirs-by-using-complex-brain-network-analysis-and-svm
#9
Hong Song, Lei Chen, RuiQi Gao, Iordachescu Ilie Mihaita Bogdan, Jian Yang, Shuliang Wang, Wentian Dong, Wenxiang Quan, Weimin Dang, Xin Yu
BACKGROUND: Schizophrenia is a kind of serious mental illness. Due to the lack of an objective physiological data supporting and a unified data analysis method, doctors can only rely on the subjective experience of the data to distinguish normal people and patients, which easily lead to misdiagnosis. In recent years, functional Near-Infrared Spectroscopy (fNIRS) has been widely used in clinical diagnosis, it can get the hemoglobin concentration through the variation of optical intensity...
December 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29291031/increased-local-connectivity-of-brain-functional-networks-during-facial-processing-in-schizophrenia-evidence-from-eeg-data
#10
Tianyi Yan, Wenhui Wang, Tiantian Liu, Duanduan Chen, Changming Wang, Yulong Li, Xudong Ma, Xiaoying Tang, Jinglong Wu, Yiming Deng, Lun Zhao
Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individuals with and without schizophrenia. Faces and tables were presented to participants, and event-related phase synchrony, represented by the phase lag index (PLI), was calculated. In addition, cortical oscillatory dynamics may be useful for understanding the neural mechanisms underlying the disparate cognitive and functional impairments in schizophrenic patients...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284259/cold-and-hot-gelling-of-alginate-graft-pnipam-a-schizophrenic-behavior-induced-by-potassium-salts
#11
Hui Guo, Mickaël De Magalhaes Goncalves, Guylaine Ducouret, Dominique Hourdet
Recently, alginates (ALG) characterized by high mannuronic content (M blocks) have been shown to undergo a reversible sol/gel transition during cooling in the presence of potassium salts. Cold gelling takes place at low temperatures, just below 0 °C for a KCl concentration of 0.3 mol/kg, but the aggregation process can be easily shifted to higher temperatures by increasing the salt concentration. In the present paper, we take advantage of this peculiar behavior to design a copolymer with schizophrenic gelling properties...
December 29, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29283732/seroprevalence-and-manifestations-of-ocular-toxoplasmosis-in-patients-with-schizophrenia
#12
Fábio Barreto Morais, Tiago Eugênio Faria E Arantes, Cristina Muccioli
PURPOSE: Recent studies have linked infectious agents such as Toxoplasma gondii to schizophrenia. We investigated the seroprevalence of T. gondii and conducted ophthalmologic examinations in schizophrenia patients and controls to identify lesions suggestive of ocular toxoplasmosis. METHODS: During 2015 and 2016, 34 schizophrenia patients and 85 healthy controls underwent ophthalmologic examination and anti-T. gondii IgG and IgM antibody measurements by chemiluminescence...
December 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29280533/comparative-effects-of-aripiprazole-and-selected-antipsychotic-drugs-on-lipid-peroxidation-in-plasma
#13
Anna Dietrich-Muszalska, Jolanta Kolińska-Łukaszuk
AIM: The aim of the present study was to evaluate and compare the effects of a new antipsychotic aripiprazole, unique due to its mechanism of action, with the effects of selected antipsychotic drugs such as quetiapine, olanzapine, clozapine, risperidone and ziprasidone (at the final concentrations corresponding to clinically effective doses used for the treatment of acute episodes of schizophrenia) on lipid peroxidation in human plasma measured by the level of TBARS (thiobarbituric acid reactive substances), which is a marker of oxidative stress...
December 27, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29273271/clozapine-use-in-patients-with-schizophrenia-and-a-comorbid-substance-use-disorder-a-systematic-review
#14
REVIEW
Belén Arranz, Marina Garriga, Clemente García-Rizo, Luis San
Lifetime prevalence of substance use disorders (SUD) in patients with schizophrenia is nearly 50%. Nicotine, alcohol, and cannabis are the substances most frequently used, with a high percentage of poly-substance users. There are few available data about pharmacological approaches in this population. Amongst antipsychotics, clozapine shows positive evidence in the literature. The aim of the present article is to provide systematic review on the efficacy of clozapine in SUD improvement in schizophrenic patients...
December 19, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29249810/schizophrenia-and-depression-two-poles-of-endocannabinoid-system-deregulation
#15
María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Luis F Callado, J Javier Meana, Javier Garzón-Niño
The activity of certain G protein-coupled receptors (GPCRs) and of glutamate N-Methyl-D-aspartate receptors (NMDARs) is altered in both schizophrenia and depression. Using postmortem prefrontal cortex samples from subjects with schizophrenia or depression, we observed a series of opposite changes in the expression of signaling proteins that have been implicated in the cross-talk between GPCRs and NMDARs. Thus, the levels of HINT1 proteins and NMDAR NR1 subunits carrying the C1 cytosolic segment were increased in depressives and decreased in schizophrenics, respect to matched controls...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29247717/higher-order-thalamic-nuclei-resting-network-connectivity-in-early-schizophrenia-and-major-depressive-disorder
#16
Jacob Penner, Elizabeth A Osuch, Betsy Schaefer, Jean Théberge, Richard W J Neufeld, Ravi S Menon, Nagalingam Rajakumar, James A Bourne, Peter C Williamson
The pulvinar and the mediodorsal (MDN) nuclei of the thalamus are higher order nuclei which have been implicated in directed effort and corollary discharge systems. We used seed-based resting fMRI to examine functional connectivity to bilateral pulvinar and MDN in 24 schizophrenic patients (SZ), 24 major depressive disorder patients (MDD), and 24 age-matched healthy controls. SZ had less connectivity than controls between the left pulvinar and precuneus, left ventral-lateral prefrontal cortex (vlPFC), and superior and medial-frontal regions, between the right pulvinar and right frontal pole, and greater connectivity between the right MDN and left dorsolateral prefrontal cortex (dlPFC)...
December 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29247287/-the-role-of-psychopharmacotherapy-in-the-development-of-social-psychiatry-in-germany
#17
REVIEW
H Helmchen
Early experiences and indications are reported that psychopharmacotherapy, particularly as prophylactic long-term medication for prevention of relapses, has led to an increased recognition of social determinants of the course of illness, especially in schizophrenic patients. As a result, institutions combining both social and psychopharmacological treatment have developed, e. g., in Berlin beginning with "Phönix" a transition home ("Übergangsheim") in 1956 to a catamnesis for long-term outpatient treatment of schizophrenic patients in 1957, a social service in 1960, a day and night hospital in 1962 up to a university department of social psychiatry in 1972 with a rich spectrum of facilities for a step by step rehabilitation of mentally ill patients...
December 15, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29241148/obesity-exacerbates-the-acute-metabolic-side-effects-of-olanzapine
#18
Logan K Townsend, Willem T Peppler, Natasha D Bush, David C Wright
Olanzapine is a second-generation antipsychotic used in the management of schizophrenia and various off-label conditions. The acute metabolic responses of olanzapine recapitulate many of the side effects associated with obesity. Obesity rates are high in the schizophrenic population, but it is unknown whether pre-existing obesity-associated metabolic dysfunction augments the acute side effects of olanzapine. To address this question, we compared the responses to olanzapine in lean and high-fat diet-induced (HFD) obese mice...
December 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29238487/morphology-of-the-corpus-callosum-and-schizophrenia-a-case-control-study-in-kashan-iran
#19
Afshin Ahmadvand, Shahab Bagherzadeh Shahidi, Hamidreza Talari, Fatemeh Sadat Ghoreishi, Gholam Abbas Mousavi
Background: Corpus Callosum (CC) plays a significant role in hemispheric communication and in lateralized brain function and behaviors. Structural abnormalities in the corpus callosum of schizophrenic patients were reported. However, previous studies regarding the relationship between morphology of CC in patients with schizophrenia and healthy people are controversial. Objective: To evaluate the morphological differences of the CC between patients with chronic schizophrenia and healthy people and to examine the relationship between the characteristics of the CC and schizophrenia severity...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29237345/correction-to-asif-et%C3%A2-al-genderwise-clinical-response-of-antipsychotics-among-schizophrenic-patients-a-prospective-observational-study-from-lahore-pakistan
#20
(no author information available yet)
No abstract text is available yet for this article.
December 13, 2017: International Journal of Psychiatry in Clinical Practice
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