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https://www.readbyqxmd.com/read/28108228/a-preliminary-study-of-endocannabinoid-system-regulation-in-psychosis-distinct-alterations-of-cnr1-promoter-dna-methylation-in-patients-with-schizophrenia
#1
Claudio D'Addario, Vincenzo Micale, Martina Di Bartolomeo, Tibor Stark, Mariangela Pucci, Alexandra Sulcova, Mariacarlotta Palazzo, Zuzana Babinska, Laura Cremaschi, Filippo Drago, A Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Osso
Compelling evidence supports the involvement of the endocannabinoid system (ECS) in psychosis vulnerability. We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subjects suffering from bipolar disorder, major depressive disorder and schizophrenia, focusing in particular on the effects of DNA methylation. We observed selective alterations of DNA methylation at the promoter of CNR1, the gene coding for the type-1 cannabinoid receptor, in schizophrenic patients (N=25) with no changes in any other disorder...
January 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28108225/female-schizophrenia-patients-and-risk-of-breast-cancer-a-population-based-cohort-study
#2
Ana Isabel Wu Chou, Yu-Chiao Wang, Cheng-Li Lin, Chia-Hung Kao
OBJECTIVE: Breast cancer is the most common type of cancer in women. This population-based cohort study aimed to examine the association between breast cancer in female schizophrenia patients and its association with the use of antipsychotics drugs. METHODS: All study subjects were selected from the Taiwan Insurance Claims Data (1998-2008). We compared the risk for breast cancer between female schizophrenia patients receiving antipsychotics (n=29,641) with female patients without any serious mental illnesses nor receiving antipsychotic drugs (n=59,282)...
January 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28104060/comparison-of-suicide-attempts-behaviors-following-smoking-cessation-treatments-among-schizophrenic-smokers
#3
I-Hsuan Wu, Hua Chen, Patrick Bordnick, Ekere James Essien, Michael Johnson, Ronald J Peters, Xin Wang, Susan M Abughosh
BACKGROUND: Smoking cessation may lead to depression in some smokers and result in increased risk of suicide. OBJECTIVE: To compare the risk of suicide attempts/behaviors associated with different smoking cessation medications among schizophrenic patients. METHODS: A retrospective cohort study was conducted using General Electric (GE) medical record database (1995-2011). The first day of being prescribed a smoking cessation medication defined as index date...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28100058/endoscopic-retrieval-of-toothbrushes-in-a-schizophrenic-patient
#4
José Luis Beristain-Hernández, Mario Eduardo Torres-Olalde, Martín Rojano-Rodríguez
Foreign bodies are a common problem in the daily endoscopic practice. Nevertheless, long objects as toothbrushes, sometimes pose a special problem when trying to remove them from the stomach, due to the difficulty of passing through the hiatus. Endoscopic retrieval of toothbrushes has seldom be reported.
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28089135/phenotypic-continuum-between-autism-and-schizophrenia-evidence-from-the-movie-for-the-assessment-of-social-cognition-masc
#5
Gilles Martinez, Charlotte Alexandre, Célia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs
Schizophrenic (SCZ) and autism (ASD) spectrum disorders share several features including social cognition impairments. In SCZ, the link between symptomatic dimensions and social cognition deficits remains unclear. The Movie for the Assessment of Social Cognition (MASC) test, available in several languages including English, investigates mental state attribution capabilities in complex interpersonal situations. After its translation into French, we used MASC to direct compare social cognition in 36 young participants with SCZ to 19 with ASD and 20 healthy controls (HC) matched for gender, age (18-25y...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28088913/a-comparative-study-of-short-term-efficacy-of-aripiprazole-and-risperidone-in-schizophrenia
#6
P B Sajeev Kumar, Ravi S Pandey, Jagadisha Thirthali, P T Siva Kumar, C Naveen Kumar
Objective To compare the short term anti-schizophrenic efficacy and side effect profile of aripiprazole with risperidone. Methodology The study was a non-randomized, naturalistic, rater blinded, prospective, 8-12 weeks, comparative trial between risperidone and aripiprazole in patients with schizophrenia. Patients already getting treatment with aripiprazole (10 to 30 mg/day) or risperidone (3 to 8mg/day) are recruited. Mini International Neuropsychiatric Interview (MINI) Plus, Positive and Negative Syndrome Scale (PANSS), Abnormal Involuntary Movement Scale (AIMS), Simpson Angus Scale (SAS), Udvalg for Klinske Undersogelser (UKU) Scale, Clinical Global Impression-severity scales were administered by principal investigator on the day of recruitment...
January 12, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28077222/prediction-of-relapse-after-cognitive-behavioral-treatment-of-gambling-disorder-in-individuals-with-chronic-schizophrenia-a-survival-analysis
#7
Enrique Echeburúa, Montserrat Gómez, Montserrat Freixa
Gambling disorder (GD) in individuals with chronic schizophrenia is relevant because there are higher rates of GD in schizophrenic populations (10%) than in the nonschizophrenic population (1%-5%). In addition, these patients have more severe alcohol use disorder (i.e., meeting at least 6 of the DSM-5 11 criteria for diagnosis of this disorder), higher depression scores, a poor adherence to treatment, and more frequent use of outpatient mental health care. One of the main problems in GD is therapeutic failure (defined as three or more lapse episodes during treatment) or relapse (three or more lapse episodes in the follow-up period)...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28076640/frontal-lobe-alterations-in-schizophrenia-a-review
#8
Ateeq Mubarik, Hassaan Tohid
Objective: To highlight the changes in the frontal lobe of the human brain in people with schizophrenia. Methods: This was a qualitative review of the literature. Results: Many schizophrenic patients exhibit functional, structural, and metabolic abnormalities in the frontal lobe. Some patients have few or no alterations, while some have more functional and structural changes than others. Magnetic resonance imaging (MRI) shows structural and functional changes in volume, gray matter, white matter, and functional activity in the frontal lobe, but the mechanisms underlying these changes are not yet fully understood...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28073465/-depression-in-relatives-of-patients-with-schizophrenia-8-month-longitudinal-outcome-of-profamille-program
#9
E Valladier, D Willard, L Romo, Y Hodé, Y Morvan
INTRODUCTION: Mental illness such as schizophrenia is a major public health concern. In France, the economic cost of schizophrenia represents 2 % of total medical expenditures. Schizophrenia has an impact on health and quality of life not only for patients but also for relatives. Family psychoeducation is a complementary therapeutic intervention to ordinary clinical care deigned to alleviate the burden of care among relatives of patients with schizophrenia. Literature suggests such programs including the patients' family members reduce the risk of relapse...
January 7, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28068943/a-case-of-gabar-antibodies-in-schizophrenia
#10
Ida S Haussleiter, Klaus-Peter Wandinger, Georg Juckel
BACKGROUND: In the last couple of years, schizophrenia was often discussed as autoimmune disease. Several antibodies were suspected, but so far there has been no proof of Gamma-aminobutyric acid (GABA) receptor antibodies in patients with schizophrenia. CASE PRESENTATION: In this case report we present a 21-year old woman with schizophrenic symptoms, who showed anti-GABAB1 antibodies when screened by a vast recombinant neurology mosaic on Human Embryonic Kidney Cells 293 (HEK293) cells...
January 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28067751/efficacy-of-clozapine-on-dopamine-supersensitivity-psychosis-in-schizophrenia
#11
Yusuke Nakata, Nobuhisa Kanahara, Hiroshi Kimura, Hiroyuki Watanabe, Masaomi Iyo
Although the effectiveness of clozapine (CLZ) for patients with treatment-resistant schizophrenia (TRS) has been well established, its active mechanism has not been completely clarified. Several clinical studies showed that neuroleptic-induced dopamine supersensitivity psychosis (DSP) could be involved in the etiology of TRS. We preliminarily explored the possible beneficial effect of CLZ for dopamine supersensitivity schizophrenia. The present study is a case series. We followed 15 patients with DSP for about 2...
January 6, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28064092/effects-of-self-and-familiarity-on-change-detection-in-patients-with-schizophrenia
#12
Anna Kochs, Stephan Köhler, Holger Merz, Philipp Sterzer
In schizophrenia, processing of self-related stimuli has been shown to be altered. It is unclear whether altered self-processing in schizophrenia is confined to cognitive functions such as self-recognition, or whether it pertains to automatic lower-level perceptual processes. Visual face processing was tested in patients with schizophrenia (n=36) and healthy controls (n=33). Using a change detection paradigm (self, famous, unknown faces), we tested whether self-related stimuli gain access to awareness preferentially...
December 24, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28063940/linking-lipid-peroxidation-and-neuropsychiatric-disorders-focus-on-4-hydroxy-2-nonenal
#13
REVIEW
Adele Romano, Gaetano Serviddio, Silvio Calcagnini, Rosanna Villani, Anna Maria Giudetti, Tommaso Cassano, Silvana Gaetani
4-hydroxy-2-nonenal (HNE) is considered to be a strong marker of oxidative stress; the interaction between HNE and cellular proteins leads to the formation of HNE-protein adducts able to alter cellular homeostasis and cause the development of a pathological state. By virtue of its high lipid concentration, oxygen utilization, and the presence of metal ions participating to redox reactions, the brain is highly susceptible to the formation of free radicals and HNE-related compounds. A variety of neuropsychiatric disorders have been associated with elevations of HNE concentration...
January 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28063323/genetic-and-epigenetic-regulation-on-the-transcription-of-gabrb2-genotype-dependent-hydroxymethylation-and-methylation-alterations-in-schizophrenia
#14
Lu Zong, Lin Zhou, Yu Hou, Lulu Zhang, Wei Jiang, Wenwei Zhang, Lijuan Wang, Xia Luo, Shiqing Wang, Cong Deng, Zhizhen Peng, Shufen Li, Jiming Hu, Hu Zhao, Cunyou Zhao
To improve our understanding of the abnormalities and non-Mendelian inheritance characteristics of schizophrenia, this study examined DNA methylation (5mC) and hydroxymethylation (5hmC) in the schizophrenia-associated GABRB2 gene encoding the type A γ-aminobutyric acid receptor β2 subunit. DNAs from the peripheral white blood cells of 279 schizophrenic patients and 256 controls from the Chinese Han population were examined to reveal that the GABRB2 promoter P1-5mC level which was correlated with olanzapine administration, P2-5mC/5hmC level, and Alu-5mC level which was correlated with administration of ziprasidone or oxcarbazepine, were increased in schizophrenic patients...
December 28, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28054990/mrna-expression-and-dna-methylation-analysis-of-serotonin-receptor-2a-htr2a-in-the-human-schizophrenic-brain
#15
Sern-Yih Cheah, Bruce R Lawford, Ross McD Young, Charles P Morris, Joanne Voisey
Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have reported inconsistent results. In this study, we examine HTR2A expression and methylation and the interaction with HTR2A polymorphisms to identify their biological significance in schizophrenia. Subjects included 25 schizophrenia and 25 control post-mortem brain samples...
January 4, 2017: Genes
https://www.readbyqxmd.com/read/28054367/development-of-an-uplc-ms-ms-method-for-routine-therapeutic-drug-monitoring-of-aripiprazole-amisulpride-olanzapine-paliperidone-and-ziprasidone-with-a-discussion-of-their-therapeutic-reference-ranges-for-chinese-patients
#16
Shao-Ting Wang, Yan Li
A highly feasible and reliable ultra-high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti-schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone and ziprasidone) simultaneously. To meet the requirements of practical clinical usage (easy-handling, high-throughput and cost effective), the pretreatment process has been especially simplified (only including protein precipitation and mobile phase dilution steps) and the UPLC separation cycle was set within 6 minutes...
January 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28053130/diagnostic-and-prognostic-significance-of-brief-limited-intermittent-psychotic-symptoms-blips-in-individuals-at-ultra-high-risk
#17
Paolo Fusar-Poli, Marco Cappucciati, Andrea De Micheli, Grazia Rutigliano, Ilaria Bonoldi, Stefania Tognin, Valentina Ramella-Cravaro, Augusto Castagnini, Philip McGuire
BACKGROUND: Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. OBJECTIVES: To address the baseline diagnostic relationship between BLIPS and the ICD-10 categories and examine the longitudinal prognostic impact of clinical and sociodemographic factors. METHODS: Prospective long-term study in UHR individuals meeting BLIPS criteria...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28049076/olfactory-identification-in-patients-with-schizophrenia%C3%A2-%C3%A2-the-influence-of-%C3%AE-endorphin-and-calcitonin-gene-related-peptide-concentrations
#18
M Urban-Kowalczyk, J Śmigielski, D Strzelecki
BACKGROUND: The relationship between the olfactory system and emotional processing is an area of growing interest in schizophrenia research. Both the orbitofrontal cortex and amygdala are involved in the processing of olfactory information, and olfactory deficits may be also influenced by endogenous opioids and calcitonin gene-related peptide (CGRP), which is probably involved in dopaminergic transmission. However, the relationship between endorphins and dopaminergic transmission has not been fully explored...
December 29, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28047515/su-f-i-67-neurometabolic-effect-induced-by-repeated-exposure-to-dizocilpine-on-prefrontal-cortex-of-schizophrenic-animal-model-using-in-vivo-proton-magnetic-resonance-spectroscopy-at-9-4-t
#19
C-H Yoo, K-H Song, S-I Lim, D-C Woo, B-Y Choe
PURPOSE: Repeated exposure of dizocilpine (MK-801) can provide a pathophysiological model for progressive development of schizophrenia. In vivo proton magnetic resonance spectroscopy ((1) H MRS) was widely used for non-invasive measurement of neurometabolites, and assessment of disease-induced neurometabolic alterations. The purpose of this study was to investigate neurometabolic alteration in prefrontal cortex (PFC) with respect to progression (from first-episode to chronic stage) of schizophrenia by using in vivo (1) H MRS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038867/parkinsonian-axial-signs-in-schizophrenia
#20
Francesca Morgante, Corrado Barbui, Michele Tinazzi
INTRODUCTION: We have recently demonstrated evidence of nigro-striatal denervation, disease progression and response to levodopa in a subgroup of patients with schizophrenia who developed parkinsonism. OBJECTIVE: In the present study, we investigated whether axial parkinsonian signs might be an early manifestation of parkinsonism in schizophrenia not necessarily related to chronic administration of antipsychotic drugs (AP) drugs. METHODS: From a baseline cohort of 299 schizophrenic patients who did not satisfy the diagnostic criteria for parkinsonism (presence of at least two of the following appendicular signs: bradykinesia, tremor, rigidity), we identified a group of patients who manifested two out of three axial parkinsonian signs (abnormality of trunk posture, hypomimia and short-step gait)...
December 23, 2016: Parkinsonism & related Disorders
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