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Schizophrenic

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https://www.readbyqxmd.com/read/29137928/camkii%C3%AE-expression-in-a-mouse-model-of-nmdar-hypofunction-schizophrenia-putative-roles-for-igf-1r-and-tlr4
#1
O M Ogundele, C C Lee
Schizophrenia (SCZ) is a neuropsychiatric disorder that is linked to social behavioral deficits and other negative symptoms associated with hippocampal synaptic dysfunction. Synaptic mechanism of schizophrenia is characterized by loss of hippocampal N-Methyl-d-Aspartate Receptor (NMDAR) activity (NMDAR hypofunction) and dendritic spines. Previous studies show that genetic deletion of hippocampal synaptic regulatory calcium-calmodulin dependent kinase II alpha (CaMKIIα) cause synaptic and behavioral defects associated with schizophrenia in mice...
November 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29134233/-genuine-motor-phenomena-in-schizophrenia-neuronal-correlates-and-pathomechanisms
#2
REVIEW
D Hirjak, G Northoff, P A Thomann, K M Kubera, R C Wolf
Despite a growing body of evidence on motor dysfunction in schizophrenia spectrum disorders, the neuronal correlates of genuine motor abnormalities (GMA) are not fully elucidated at present. Moreover, the clinical relevance of a potential "motor intermediate phenotype" remains controversial. This systematic review aims at characterizing a "motor intermediate phenotype" in schizophrenia spectrum disorders. The second goal of this systematic review is to discuss GMA-associated brain alterations as potential biomarkers of psychosis risk syndrome and manifest motor symptoms against the background of current neuroimaging evidence...
November 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29120669/schizophrenia-as-a-psychosomatic-illness-an-interdisciplinary-approach-between-lacanian-psychoanalysis-and-the-neurosciences
#3
Yorgos Dimitriadis
According to Lacan's theory of schizophrenia (as well as other delirious forms of psychosis), under certain conditions the signifying function breaks down, thus turning the schizophrenic individual's world into one in which a number of events become enigmatic and signal him or her. The schizophrenic individual tries to deal with these signs that besiege him or her either by means of an interpretative attitude (a stable delusional mood) or by apathy. These two types of responses correspond with the stereotypical (and mood) processes by which the schizophrenic individual attempts to avoid the distress provoked by the enigmatic desire of the Other, while simultaneously corresponding with psychosomatic processes of the brain organ...
November 9, 2017: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/29119704/pharmacokinetics-of-rp5063-following-single-doses-to-normal-healthy-volunteers-and-multiple-doses-over-10-days-to-stable-schizophrenic-patients
#4
Marc Cantillon, Robert Ings, Laxminarayan Bhat
RP5063, a multimodal dopamine (D)-serotonin (5-HT) stabilizer, possesses high affinity for D2/3/4 and 5-HT1A/2A/2B/2C/6/7 receptors and moderate affinity for the serotonin transporter. Two phase I studies characterized the pharmacokinetics of a single dose (10 and 15 mg fasting, 15 mg fed/fasting) in healthy volunteers and multiple doses (10, 20, 50, and 100 mg fed) over 10 days in patients with stable schizophrenia. RP5063 displayed a dose-dependent Cmax at 4 to 6 h, linear dose proportionality for both Cmax and AUC, and a half-life between 40 and 71 h...
November 8, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29112096/genetic-analysis-of-common-variants-in-the-znf804a-gene-with-schizophrenia-and-major-depressive-disorder
#5
Qingzhong Wang, Weidong Ji, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Qiang Yu, Guoyin Feng, Jue Ji, Yujiong Wang, Yongyong Shi
AIM/OBJECTIVES/BACKGROUND: ZNF804A has been investigated widely as a candidate susceptibility gene for mental disorders in individuals of different ethnicities. However, in the Han Chinese population, most studies of this gene have focused on associations of the common single nucleotide polymorphism (SNP) rs1344706. METHODS: To investigate additional common variants within ZNF804A, we carried out a case-control study of 13 SNPs distributed across the whole gene, in 1330 schizophrenic patients, 1045 major depressive disorder patients, and 1235 normal controls...
November 3, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29110776/psychiatric-syndromes-other-than-dementia
#6
Karl Bechter, Florian Deisenhammer
There is wide variability in how psychiatry guidelines and textbooks address the question of cerebrospinal fluid (CSF) diagnostics in the screening of psychiatric disorders. A United States-based textbook confirms that there is no consensus about which laboratory investigation should be routinely performed in psychiatric patients, but with respect to CSF diagnostics, the differences are even more striking. A survey among European experts showed a wide variety of opinions regarding clinical use and criteria in various countries of Europe and worldwide: some psychiatrists, mostly university hospital-based, recommended performing CSF diagnostics in every patient first experiencing severe mental illness (SMI), but especially in patients from the schizophrenia spectrum, whereas others almost never perform CSF examinations themselves and usually refer patients to neurology departments if necessary...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29110334/frontotemporal-dementia-with-trans-activation-response-dna-binding-protein-43-presenting-with-catatonic-syndrome
#7
Ryohei Watanabe, Ito Kawakami, Mitsumoto Onaya, Shinji Higashi, Nobutaka Arai, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Arai
Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder...
November 7, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29104802/a-rasch-analysis-between-schizophrenic-patients-and-the-general-population
#8
Frederic Denis, Pablo Bizien, Stéphanie Tubert-Jeannin, Mohamad Hamad, Benoit Trojak, Nathalie Rude, Jean-Benoit Hardouin
Background: The aim of this study was to test the General Oral Health Assessment Index Questionnaire (GOHAI) items for differential item functioning (DIF) according to demographic characteristics (gender, age) and mental health status (schizophrenic disorders versus general population) using Rasch analysis. Methods: This is a cross-sectional study using aggregated baseline data from a validation study of the GOHAI in the French general population (GP) and similar validation study in persons with schizophrenia (PWS)...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/29094060/representation-mediated-aversion-as-a-model-to-study-psychotic-like-states-in-mice
#9
Arnau Busquets-Garcia, Edgar Soria-Gómez, Guillaume Ferreira, Giovanni Marsicano
Several paradigms for rodent models of the cognitive and negative endophenotypes found in schizophrenic patients have been proposed. However, significant efforts are needed in order to study the pathophysiology of schizophrenia-related positive symptoms. Recently, it has been shown that these positive symptoms can be studied in rats by using representation-mediated learning. This learning measure the accuracy of mental representations of reality, also called 'reality testing'. Alterations in 'reality testing' performance can be an indication of an impairment in perception which is a clear hallmark of positive psychotic-like states...
June 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29082784/genderwise-clinical-response-of-antipsychotics-among-schizophrenic-patients-a-prospective-observational-study-from-lahore-pakistan
#10
Usama Asif, Zikria Saleem, Mahrukh Yousaf, Hamid Saeed, Furqan Khurshid Hashmi, Muhammad Islam, Mohamed Azmi Hassali, Fahad Saleem
OBJECTIVE: The study was aimed to evaluate the gender specific response to adherence and occurrence of side effects among schizophrenic patients in Lahore, Pakistan. METHODS: A prospective study was performed for a period of 1 year among 180 newly diagnosed schizophrenics, aged 20-60 years to observe the symptoms, medication adherence and side effects. MMAS-4 was used to evaluate medication adherence, LUNSER for side effects and PANSS to measure positive and negative symptoms...
October 30, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29081418/neurobiological-parameters-in-quantitative-prediction-of-treatment-outcome-in-schizophrenic-patients
#11
Andrey F Iznak, Ekaterina V Iznak, Tatiana P Klyushnik, Georgy M Kobel'kov, Elena V Damjanovich, Igor V Oleichik, Lilia I Abramova
The aim of the study was to reveal the set of neurobiological parameters informative for individual quantitative prediction of therapeutic response in schizophrenic patients. Correlation and regression analyses of quantitative clinical scores (by Positive And Negative Syndromes Scale - PANSS), together with background EEG spectral power values and four immunological parameters: enzymatic activity of leukocyte elastase and of alpha-1 proteinase inhibitor, as well as serum levels of autoantibodies to common myelin protein and to nerve growth factor, were performed in 50 patients (all females, aged 32...
October 24, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29079989/osteopenia-and-the-physical-function-in-japanese-patients-with-schizophrenia
#12
Satoru Uchida, Tsuyoshi Ichinose, Yoichi Iizuka, Koichi Okamura, Hitoshi Shitara, Manabu Yamazaki, Kenji Takagishi, Haku Iizuka
We evaluated the state of osteopenia and the physical function in 121 schizophrenic patients. These factors were worse in the inpatient group than in the outpatient group. The age, sex, body mass index (BMI), and physical function were correlated to the state of osteopenia. Physicians should consider the risk of osteopenia in elderly female psychiatric patients with low BMI. PURPOSE: Information about the actual state of osteopenia in patients with schizophrenia is limited. In the present study, we evaluated the factors related to osteopenia and patient's physical function and compared these factors between inpatients and outpatients...
October 27, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29078744/assessment-of-the-relationship-between-food-addiction-and-nutritional-status-in-schizophrenic-patients
#13
Özge Küçükerdönmez, Murat Urhan, Merve Altın, Özge Hacıraifoğlu, Burak Yıldız
OBJECTIVE: Obesity is one of today's most important public health problems. It is suggested that overeating and substance addiction show similarities, and addiction to food may be an important factor in the obesity epidemic. This study aimed to determine the prevalence of food addiction among schizophrenic patients and to examine the relationship between food addiction and anthropometric measurements and dietary nutrient intake. METHODS: Study participants included a total of 104 schizophrenic outpatients, 62 females and 42 males...
October 27, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29073600/new-insight-into-affectivity-in-schizophrenia-from-the-phenomenology-of-marc-richir
#14
Tudi Gozé, Till Grohmann, Jean Naudin, Michel Cermolacce
BACKGROUND: According to Karl Jaspers, psychopathology requires a comprehensive method, understood as a systematic exploration of the first-person perspective of the patient's experience. At the same time, however, schizophrenia for Jaspers is characterized by its radical incomprehensibility. In addition, Rümke's so-called "praecox feeling" paradoxically combines the incomprehensibility of schizophrenic experience and the evidence of its pathological manifestation in the encounter. AIM: Through a re-examination of the notions of affectivity and interaffective contact we propose a coherent theoretical model to explain the clinician's paradoxical understanding of schizophrenia...
October 27, 2017: Psychopathology
https://www.readbyqxmd.com/read/29072157/the-study-of-the-antisaccade-performance-and-contingent-negative-variation-characteristics-in-first-episode-and-chronic-schizophrenia-patients
#15
Anna V Kirenskaya, Andrej A Tkachenco, Vladimir Yu Novototsky-Vlasov
The study tested whether the antisaccade (AS) performance and Contingent Negative Variation (CNV) measures differed between the first-episode and chronic patients to provide the evidence of PFC progressive functional deterioration. Subjects included 15 first-episode and 20 chronic schizophrenic patients (with the duration of illness more than 5 years), and 21 control subjects. The first-episode and chronic patients had significantly elevated error percent (p < .05, effect size 1.10 and p < .001, effect size 1...
October 26, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/29069946/paternal-and-maternal-age-as-risk-factors-for-schizophrenia-a-case-control-study
#16
Konstantinos N Fountoulakis, Xenia Gonda, Melina Siamouli, Panagiotis Panagiotidis, Katerina Moutou, Ioannis Nimatoudis, Siegfried Kasper
OBJECTIVE: Advanced parental age might constitute a generic risk factor for mental and somatic disorders. The current study tested whether this concerns also patients with schizophrenia. METHODS: A total of 231 schizophrenic, 56 other severe mental disorders patients and 204 controls were diagnosed according to DSM-IV-TR. Data were tested with ANOVA models including relative risk and odds ratios. RESULTS: Patients with schizophrenia manifested higher paternal (32...
October 25, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29065847/long-term-administration-of-antipsychotic-drugs-in-schizophrenia-and-influence-of-substance-and-drug-abuse-on-the-disease-outcome
#17
F-M Werner, Rafael Coveñas
BACKGROUND: Many schizophrenic patients with a long-term administration of antipsychotic drugs do not regularly adhere to the prescribed pharmacotherapy. Antipsychotic drugs constitute a palliative, but not a curative treatment, and the long-term effect of these drugs is not secure. Patients tend to consume nicotine and alcohol, as well as some patients consume drugs such as cannabis and amphetamines. OBJECTIVE: The objective of this mini-review is to examine the reasons for the high tendency of schizophrenic patients to consume alcohol, nicotine and drugs and in addition to suggest measures to reduce the abuse of substances and drugs...
October 20, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29064910/a-molecular-pathway-analysis-informs-the-genetic-risk-for-arrhythmias-during-antipsychotic-treatment
#18
Ellen Kure Fischer, Antonio Drago
Arrhythmias are a frequent and potentially fatal side effect of antipsychotic treatment. Strict ECG monitoring and clinical interviews are the standards used to prevent arrhythmias. A biologic predictive tool is missing. The identification of a genetic makeup at risk of antipsychotic-induced arrhythmias is the aim of the present investigation. The aim of this study was to identify a molecular pathway enriched in single nucleotide polymorphisms associated with antipsychotic-induced QTc modifications. In total, 661 schizophrenic individuals from the CATIE study, M=486 (73...
October 23, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29064711/schizophrenic-diblock-copolymer-functionalized-nanoparticles-as-temperature-responsive-pickering-emulsifiers
#19
Mikhil Ranka, Hari Katepalli, Daniel Blankschtein, T Alan Hatton
Stimuli-responsive pickering emulsions have received considerable attention in recent years, and the utilization of temperature as a stimulus has been of particular interest. Previous efforts have led to responsive systems that enable the formation of stable emulsions at room temperature, which can subsequently be triggered to destabilize with an increase in temperature. The development of a thermoresponsive system that exhibits the opposite response, however, i.e., one that can be triggered to form stable emulsions at elevated temperatures and subsequently be induced to phase separate at lower temperatures, has so far been lacking...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29060345/neuronal-desynchronization-as-marker-of-an-impaired-brain-network
#20
S Schulz, B Legorburu Cladera, B Giraldo, M Bolz, K J Bar, A Voss
Synchronization is a central key feature of neural information processing and communication between different brain areas. Disturbance of oscillatory brain rhythms and decreased synchronization have been associated with different disorders including schizophrenia. The aim of this study was to investigate whether synchronization (in relaxed conditions with no stimuli) between different brain areas within the delta, theta, alpha (alpha1, alpha2), beta (beta1, beta2), and gamma bands is altered in patients with a neurological disorder in order to generate significant cortical enhancements...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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