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https://www.readbyqxmd.com/read/28327672/tox-and-adipoq-gene-polymorphisms-are-associated-with-antipsychotic-induced-weight-gain-in-han-chinese
#1
Shen Li, Chengai Xu, Yuan Tian, Xueshi Wang, Rui Jiang, Miaomiao Zhang, Lili Wang, Guifu Yang, Ying Gao, Chenyu Song, Yukun He, Ying Zhang, Jie Li, Wei-Dong Li
To find the genetic markers related to the antipsychotic-induced weight gain (AIWG), we analyzed associations among candidate gene single-nucleotide polymorphisms (SNPs) and quantitative traits of weight changes and lipid profiles in a Chinese Han population. A total of 339 schizophrenic patients, including 86 first-episode patients (FEPs), meeting the entry criteria were collected. All patients received atypical antipsychotic drug monotherapy and hospitalization and were followed for 12 weeks. Forty-three SNPs in 23 candidate genes were calculated for quantitative genetic association with AIWG, performed by PLINK...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327107/brain-structure-differences-among-male-schizophrenic-patients-with-history-of-serious-violent-acts-an-mri-voxel-based-morphometric-study
#2
Noriomi Kuroki, Hiroko Kashiwagi, Miho Ota, Masanori Ishikawa, Hiroshi Kunugi, Noriko Sato, Naotsugu Hirabayashi, Toshio Ota
BACKGROUND: The biological underpinnings of serious violent behaviors in patients with schizophrenia remain unclear. The aim of this study was to identify the characteristics of brain morphometry in patients with schizophrenia and a history of serious violent acts, who were being treated under relatively new legislation for offenders with mental illness in Japan where their relevant action should be strongly associated with their mental illness. We also investigated whether morphometric changes would depend on types of serious violent actions or not...
March 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28324996/analysis-of-the-non-stationarity-of-neural-activity-during-an-auditory-oddball-task-in-schizophrenia
#3
P Nunez, J Poza, J Gomez-Pilar, A Bachiller, C Gomez, A Lubeiro, V Molina, R Hornero
The aim of this study was to characterize brain dynamics during an auditory oddball task. For this purpose, a measure of the non-stationarity of a given time-frequency representation (TFR) was applied to electroencephalographic (EEG) signals. EEG activity was acquired from 20 schizophrenic (SCH) patients and 20 healthy controls while they underwent a three-stimulus auditory oddball task. The Degree of Stationarity (DS), a measure of the non-stationarity of the TFR, was computed using the continuous wavelet transform...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28294132/5-ht2c-agonists-modulate-schizophrenia-like-behaviors-in-mice
#4
Vladimir M Pogorelov, Ramona M Rodriguiz, Jianjun Cheng, Mei Huang, Claire M Schmerberg, Herbert Y Meltzer, Bryan L Roth, Alan P Kozikowski, William C Wetsel
All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D2 or serotonin (5-HT2A) receptors, or both; however, these medications are not universally effective, they may produce undesirable side-effects, and provide only partial amelioration of negative and cognitive symptoms. The heterogeneity of pharmacological responses in schizophrenic patients suggests additional drug-targets may be effective in improving aspects of this syndrome. Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss promoting capabilities...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28291982/serum-folate-and-homocysteine-in-chronic-schizophrenic-patients
#5
Adam Wysokiński
No abstract text is available yet for this article.
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28290151/deficit-schizophrenia-is-characterized-by-defects-in-igm-mediated-responses-to-tryptophan-catabolites-trycats-a-paradigm-shift-towards-defects-in-natural-self-regulatory-immune-responses-coupled-with-mucosa-derived-trycat-pathway-activation
#6
Buranee Kanchanatawan, Sunee Sirivichayakul, Kiat Ruxrungtham, André F Carvalho, Michel Geffard, George Anderson, Michael Maes
Deficit schizophrenia is accompanied by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway, as indicated by increased IgA responses to noxious (NOX) TRYCATs, but not regulatory or protective (PRO) TRYCATs, suggesting increased neurotoxic, excitotoxic, inflammatory, and oxidative potential. No previous studies examined IgM-mediated autoimmune responses to the TRYCAT pathway in deficit versus nondeficit schizophrenia. We measured IgM responses to NOX TRYCATs, namely, quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and PRO TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA), in 40 healthy controls and 40 deficit and 40 nondeficit schizophrenic patients...
March 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28289782/neuro-psychopharmacological-perspective-of-orphan-receptors-of-rhodopsin-class-a-family-of-g-protein-coupled-receptors
#7
REVIEW
Muhammad Zahid Khan, Ling He
BACKGROUND: In the central nervous system (CNS), G protein-coupled receptors (GPCRs) are the most fruitful targets for neuropsychopharmacological drug development. Rhodopsin (class A) is the most studied class of GPCR and includes orphan receptors for which the endogenous ligand is not known or is unclear. Characterization of orphan GPCRs has proven to be challenging, and the production pace of GPCR-based drugs has been incredibly slow. OBJECTIVE: Determination of the functions of these receptors may provide unexpected insight into physiological and neuropathological processes...
March 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28279926/determination-of-drugs-in-plasma-samples-by-disposable-pipette-extraction-with-c18-bsa-phase-and-liquid-chromatography-tandem-mass-spectrometry
#8
Mônia Ap Lemos Pinto, Israel D de Souza, Maria Eugênia C Queiroz
This work describes restricted access material (RAM) constituted of porous octadecylsilane particles with the outer surface covered with bovine serum albumin (C18-BSA) as a stationary phase to extract drugs from plasma samples by disposable pipette extraction (DPX) for further analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The C18-BSA phase simultaneously excluded macromolecules by chemical diffusion barrier (BSA network) and enrichment of the interior phase (C18) with drug traces by sorption...
March 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28277401/zotepine-associated-hypothermia-in-a-schizophrenic-inpatient
#9
Ting-Ren Chen, Ying-Chang Chen, Wen-Chen Ouyang
No abstract text is available yet for this article.
March 9, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28273660/other-persons-on-the-phenomenology-of-interpersonal-experience-in-schizophrenia-ancillary-article-to-eawe-domain-3
#10
Giovanni Stanghellini, Massimo Ballerini, Milena Mancini
In this paper, we discuss the philosophical and psychopathological background of Domain 3, Other persons, of the Examination of Anomalous World Experiences (EAWE). The EAWE interview aims to describe the manifold phenomena of the schizophrenic lifeworld in all of their concrete and distinctive features, thus complementing a more abstract, symptom-focused approach. Domain 3, Other persons, focuses specifically on subjectively experienced interpersonal disturbances that may be especially common in schizophrenia...
March 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/28273278/catechol-o-methyltransferase-comt-polymorphisms-modulate-working-memory-in-individuals-with-schizophrenia-and-healthy-controls
#11
Camila T Matsuzaka, Denise Christofolini, Vanessa K Ota, Ary Gadelha, Arthur A Berberian, Cristiano Noto, Diego R Mazzotti, Leticia M Spindola, Patricia N Moretti, Marilia A C Smith, Maria I Melaragno, Sintia I Belangero, Rodrigo A Bressan
Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks...
March 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28272261/abnormal-parietal-encephalomalacia-associated-with-schizophrenia-a-case-report
#12
Fen Pan, Jun-Yuan Wang, Yi Xu, Man-Li Huang
RATIONALE: It is widely believed that structural abnormalities of the brain contribute to the pathophysiology of schizophrenia. The parietal lobe is a central hub of multisensory integration, and abnormities in this region might account for the clinical features of schizophrenia. However, few cases of parietal encephalomalacia associated with schizophrenia have been described. PATIENT CONCERNS AND DIAGNOSES: In this paper, we present a case of a 25-year-old schizophrenia patient with abnormal parietal encephalomalacia...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28269178/structural-brain-network-analysis-in-schizophrenia-using-minimum-spanning-tree
#13
Ali Anjomshoa, Mahsa Dolatshahi, Fatemeh Amirkhani, Farzaneh Rahmani, Mehdi M Mirbagheri, Mohammad Hadi Aarabi
Schizophrenia is a mental disorder in which functional and structural brain networks are disrupted. Classical network analysis has been used by many researchers to quantify brain networks and to study the network changes in schizophrenia, but unfortunately metrics used in this classical method highly depend on the networks' density and weight; the comparisons made by this method are biased. The minimum spanning tree (MST) is an alternative method to solve this problem, but its usefulness in studying the schizophrenic brain network has not been examined yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259879/basic-self-disturbances-beyond-schizophrenia-discrepancies-and-affinities-in-panic-disorder-an-empirical-clinical-study
#14
Luís Madeira, Sergio Carmenates, Cristina Costa, Ludgero Linhares, Giovanni Stanghellini, Maria Luísa Figueira, Louis Sass
BACKGROUND: Anomalous self-experiences (ASEs), presumably involving alterations in "core" or "minimal self," have been studied as manifest in schizophrenia and its spectrum, in contrast with mood disorder and personality disorder samples. This is the first study to examine ASEs in panic disorder (PD), beginning the exploration of these disturbances of subjectivity in anxiety disorders. We aimed to clarify what might, or might not, be specific to the schizophrenia spectrum domain - which, in turn, could be useful for developing pathogenetic models for various disorders...
March 3, 2017: Psychopathology
https://www.readbyqxmd.com/read/28257447/exploratory-analysis-of-the-french-version-of-the-beliefs-about-medicines-questionnaire-in-patients-with-severe-mental-disorders-factorial-structure-and-reliability-in-specific-populations-of-schizophrenic-bipolar-and-depressive-patients
#15
Ludovic Samalin, Ingrid de Chazeron, Raoul Belzeaux, Pierre-Michel Llorca
OBJECTIVES: The aims of our study were to explore the factor structure and psychometric properties of the French version of the Beliefs about Medicines Questionnaire (BMQ) in patients with severe mental illness and in specific populations of patients with schizophrenia, bipolar disorder and major depressive disorder. METHODS: A cross-sectional study including patients with schizophrenia, bipolar disorder and major depressive disorder was conducted (n = 150). Principal component analysis (PCA), reliability and validity of the French version of the BMQ were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28252601/-specificity-of-spatial-organization-of-evoked-eeg-rhythms-in-patients-with-paranoid-schizophrenia
#16
V K Bochkarev, A V Kirenskaya, S V Solnceva, A A Tkachenko
AIM: The study aimed at analyzing the spatial patterns of evoked event-related oscillations in patients with paranoid schizophrenia and their relationship with clinical symptoms of disease. MATERIAL AND METHODS: Evoked delta, theta, alpha, beta, and gamma rhythms in response to target auditory stimulus in an oddball paradigm were studied in 21 schizophrenic patients and 22 healthy subjects. The independent spatial patterns were revealed within each of the frequency range using the principal component analysis...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28243470/efficacy-of-memantine-in-schizophrenic-patients-a-systematic-review
#17
REVIEW
Giuseppe Di Iorio, Gaia Baroni, Marco Lorusso, Chiara Montemitro, Maria Chiara Spano, Massimo di Giannantonio
Several evidences support the hypothesis that glutamatergic dysfunction may be implicated in the pathogenesis of schizophrenia and in the last few years great interest has been focused on the role of the N-methyl-D-aspartate receptor (NMDAR). Glutamate is the main excitatory neurotransmitter in human CNS and it plays a prominent role in synaptic plasticity, learning, and memory and other cognitive functions. Increasing interest in memantine add-on therapy in schizophrenic patients with negative and cognitive symptoms may suggest that memantine could be a new promising treatment in schizophrenia...
2017: Journal of Amino Acids
https://www.readbyqxmd.com/read/28242149/-hallucinations-etiological-analysis-of-children-admitted-to-a-pediatric-emergency-department
#18
D Vareilles, C Bréhin, C Cortey, A-L Chevrin, T Hamon, M Vignes, Y Chaix, I Claudet
Children's hallucinations pose the dual challenge of diagnosing a possible medical emergency and a possible psychiatric disorder. PURPOSE: The main objective was to analyze the causes of such hallucinations in children presenting to a pediatric emergency department. MATERIAL AND METHODS: We conducted a single-center, observational, retrospective study including all children aged less than 15 years experiencing hallucinations and admitted to our tertiary level pediatric emergency department between 1 January 2007 and 31 December 2015...
February 24, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28241130/nardostachys-jatamansi-targets-bdnf-trkb-to-alleviate-ketamine-induced-schizophrenia-like-symptoms-in-rats
#19
Anjali Janardhanan, Anjana Sadanand, Arambakkam Janardhanam Vanisree
OBJECTIVE: Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of dopamine and glutamate transmission at NMDA receptors. De-regulated brain-derived neurotrophic factor (BDNF), i.e., its signalling through the tropomyosin receptor kinase B (TrkB) receptor, is a major feature of schizophrenia...
February 28, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28239361/deictic-and-propositional-meaning-new-perspectives-on-language-in-schizophrenia
#20
Vitor C Zimmerer, Stuart Watson, Douglas Turkington, I Nicol Ferrier, Wolfram Hinzen
Emerging linguistic evidence points at disordered language behavior as a defining characteristic of schizophrenia. In this article, we review this literature and demonstrate how a framework focusing on two core functions of language-reference and propositional meaning-can conceptualize schizophrenic symptoms, identify important variables for risk assessment, diagnosis, and treatment, and inform cognitive behavioral therapy and other remedial approaches. We introduce the linguistic phenomena of deictic anchoring and propositional complexity, explain how they relate to schizophrenic symptoms, and show how they can be tracked in language behavior...
2017: Frontiers in Psychiatry
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