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https://www.readbyqxmd.com/read/28818505/schizophrenia-with-prominent-catatonic-features-a-selective-review
#1
Gabor S Ungvari, Jozsef Gerevich, Rozália Takács, Gábor Gazdag
A widely accepted consensus holds that a variety of motor symptoms subsumed under the term 'catatonia' have been an integral part of the symptomatology of schizophrenia since 1896, when Kraepelin proposed the concept of dementia praecox (schizophrenia). Until recently, psychiatric classifications included catatonic schizophrenia mainly through tradition, without compelling evidence of its validity as a schizophrenia subtype. This selective review briefly summarizes the history, psychopathology, demographic and epidemiological data, and treatment options for schizophrenia with prominent catatonic features...
August 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28809856/decreased-nox2-expression-in-the-brain-of-patients-with-bipolar-disorder-association-with-valproic-acid-prescription-and-substance-abuse
#2
T Seredenina, S Sorce, F R Herrmann, X-J Ma Mulone, O Plastre, A Aguzzi, V Jaquet, K-H Krause
Neuroinflammation and increased oxidative stress are believed to contribute to the development of psychiatric diseases. Animal studies have implicated NADPH oxidases (NOX) as relevant sources of reactive oxygen species in the brain. We have analyzed the expression of NOX isoforms in post-mortem brain samples from patients with psychiatric disorders (schizophrenia, bipolar disorder) and non-psychiatric subjects. Two collections from the Stanley Medical Research Institute were studied: the Array Collection (RNA, 35 individuals per group), and a neuropathology consortium collection (paraffin-embedded sections, 15 individuals per group)...
August 15, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28807542/rapid-and-simple-analysis-of-disease-associated-biomarkers-of-taiwanese-patients-with-schizophrenia-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry
#3
Tiao-Lai Huang, Li-Hua Lo, Jentaie Shiea, Hung Su
BACKGROUND: Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry (MALDI-TOF MS) is an extremely sensitive analytical tool for characterizing biological compounds in bio samples. In this study, we applied MALDI-TOF MS to assess potential protein biomarkers in the peripheral blood mononuclear cells (PBMCs) of patients with schizophrenia in the acute phase, recovery phase and healthy controls in Taiwan. METHODS: We recruited 40 participants, including 20 pairs of patients diagnosed with schizophrenia in the acute phase, after four-week treatment with drug in the recovery phase, and 20 healthy controls...
August 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28806606/imbalance-between-abstract-and-concrete-repetitive-thinking-modes-in-schizophrenia
#4
Pierre Maurage, Pierre Philippot, Delphine Grynberg, Dominique Leleux, Benoît Delatte, Camille Mangelinckx, Jan-Baptist Belge, Eric Constant
OBJECTIVE: Repetitive thoughts can be divided in two modes: abstract/analytic (decontextualized and dysfunctional) and concrete/experiential (problem-focused and adaptive). They constitute a transdiagnostic process involved in many psychopathological states but have received little attention in schizophrenia, as earlier studies only indexed increased ruminations (related to dysfunctional repetitive thoughts) without jointly exploring both modes. This study explored the two repetitive thinking modes, beyond ruminations, to determine their imbalance in schizophrenia...
July 1, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28805197/family-of-a-person-suffering-from-schizophrenia-in-the-context-of-a-qualitative-approach-to-understanding-the-family-as-a-system
#5
Andrzej Witusik
Qualitative analysis of the family system including a person suffering from schizophrenia is an underestimated research paradigm in modern psychiatry, clinical psychology and psychotherapy. This method is important both from the cognitive point of view and for evaluation of the effectiveness of therapy. AIM: The aim of the study was a qualitative analysis of the therapeutic process in a family whose member is suffering from schizophrenic psychosis. MATERIALS AND METHODS: The study of the process using qualitative research methodology in the paradigm of systemic thinking pointing to the mutual interactions in the family system inducing relapses in the identified patient, with identification of triangulation processes, transgenerational myths inheritance and coalitions formed by the family members...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28804672/necessity-of-oral-health-intervention-in-schizophrenic-patients-a-review
#6
REVIEW
Swati Gupta, Pratibha Pk, Richa Gupta
Individuals with mental illness often cannot perform day to day activities due to a psychiatric or emotional disorder. Schizophrenia is one such psychiatric disorder characterized by worsening self-care ability with progressing mental illness. This disease may potentially deteriorate oral health by affecting the subject's ability to perform oral hygiene measures. Literature on oral disease manifestations in schizophrenia is limited. Lack of desire for oral health care as well as generally poor awareness of oral health issues in these patients, compounded further by side effects of medications, may complicate dental management in schizophrenic patients...
December 2016: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/28801847/assessment-of-functioning-and-disability-in-patients-with-schizophrenia-using-the-who-disability-assessment-schedule-2-0-in-a-large-scale-database
#7
Ruey Chen, Tsan-Hon Liou, Kwang-Hwa Chang, Chia-Feng Yen, Hua-Fang Liao, Wen-Chou Chi, Kuei-Ru Chou
Schizophrenia is a common mental disorder characterized by deficits in multiple domains of functioning. This study is arguably the first of its kind in Taiwan to examine, in a multifaceted and objective manner, the disability of patients with schizophrenia and the factors affecting it. A cross-sectional design was adopted to gather data from 24,299 patients with schizophrenia who were listed in the Taiwan Databank of Persons with Disabilities. The level of disability in these patients was measured using the World Health Organization Disability Assessment Schedule 2...
August 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28798699/schizophrenia-or-atypical-lupus-erythematosus-with-predominant-psychiatric-manifestations-over-25%C3%A2-years-case-analysis-and-review
#8
Axel Mack, Christiane Pfeiffer, E Marion Schneider, Karl Bechter
We observed a case over 25 years of relapsing-remitting schizophrenic spectrum disorder, varying regarding the main symptomatology between more depressive or more schizoaffective or rather typical schizophrenic syndrome. Diseased phases were repeatedly accompanied by minor skin lesions, which were initially classified as mixed tissue disorder. Psychotic phases were waxing-waning over years. During one later relapse, skin involvement was severe, classified to likely represent an allergic reaction to psychopharmaca; this generalized exanthema remitted rapidly with cortisone treatment and azathioprine...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28783941/five-month-persistent-extrapyramidal-symptoms-following-a-single-injection-of-paliperidone-palmitate-a-case-report
#9
Seoyoung Jang, Jungmin Woo
Long-acting injectable (LAI) antipsychotics are useful in the treatments for schizophrenic patients with poor adherence due to their maintaining feature of therapeutic plasma level without daily administrations. However, their long-lasting property can cause complicated problems such as a long-lasting side effect. We report a patient who experienced LAI-induced extrapyramidal symptoms (EPSs) for 5 months after a single injection. During that period, every trial to ameliorate this condition turned out to be a failure...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28777866/-association-of-val66met-polymorphism-of-brain-derived-neurotrophic-factor-gene-with-cognitive-impairment-and-clinical-symptoms-in-first-episode-schizophrenia
#10
Chengcheng Zhang, Xiaochu Gu, Qiang Wang, Mingli Li, Wei Deng, Wanjun Guo, Liansheng Zhao, Xiaohong Ma, Tao Li
OBJECTIVE: To assess the association of cognitive impairment and clinical symptoms in first-episode schizophrenia with the Val66Met (rs6265) polymorphism of brain-derived neurotrophic factor (BDNF) gene. METHODS: For 87 patients with first-episode schizophrenia and 76 healthy controls, the Val66Met polymorphism was determined with a Taqman Assay-on-Demand method. Wechsler intelligence test was carried out for all participants. Correlation of cognitive impairment with clinical severity was also analyzed...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28766129/use-and-safety-of-antiepileptic-drugs-in-psychiatric-inpatients-data-from-the-amsp-study
#11
Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R Engel, Alexandra Kleimann, Susanne Stübner, Waldemar Greil, Sermin Toto
The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%...
August 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28764274/comparison-of-neurological-soft-signs-between-psychotic-and-non-psychotic-patients
#12
Abdollah Farhadi Nasab, Bahare Sabbagh Abrishami, Behnaz Ghavami, Seyed Mostafa Hosseini-Zijoud
INTRODUCTION: Neurological Soft Signs (NSS) are a group of non-specific signs manifested in some psychiatric patients. Till date, most studies have focused on NSS in schizophrenic patients. AIM: In the current study, the mean NSS score was compared between psychotic and non psychotic patients. MATERIALS AND METHODS: This descriptive analytical study was conducted on 96 hospitalized patients having psychotic disorders. The patients were first examined by a psychiatrist and their axis I diagnoses (according to DSM-IV-TR) were made...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761468/seroepidemiological-study-of-toxoplasma-gondii-infection-among-psychiatric-patients-in-mashhad-northeast-of-iran
#13
Ebrahim Abdollahian, Reza Shafiei, Naghmeh Mokhber, Kurosh Kalantar, Abdolmajid Fata
BACKGROUND: Psychiatric patients have an increased risk of some infections like toxoplasmosis. Investigations on Toxoplasma gondii infection among psychiatric patients have been limited in Mashhad, Northeast of Iran. In this case-control study, prevalence of T. gondii was investigated by serological method. METHODS: This case-control study was performed among psychiatric patients admitted to Avicenna Hospital in Mashhad, Northeast of Iran. Three hundred and fifty inpatients and 350 controls were examined in 2012-2013 for detection of IgG and IgM antibodies against T...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28757777/delusions-of-control-in-a-case-of-schizophrenia-coexisting-with-a-large-cerebellar-arachnoid-cyst
#14
Ying-Ying Wu, Yu-Chih Shen
Arachnoid cyst is a benign, congenital space-occupying brain lesion, which has been found in patients with schizophrenia. The association between arachnoid cyst and schizophrenia remains controversial, but the location of the arachnoid cyst may give rise to a specific symptom presentation in schizophrenia. We present a 31-year-old woman with an established diagnosis of schizophrenia coexisting with a large cerebellar arachnoid cyst who presented mainly with delusions of control. This cerebellar arachnoid cyst and schizophrenia may have been found together coincidentally or brain dysfunction due to this cerebellar arachnoid cyst may have caused or contributed to the appearance of psychotic symptoms...
April 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28753464/mortality-and-the-relationship-of-somatic-comorbidities-to-mortality-in-schizophrenia-a-nationwide-matched-cohort-study
#15
I Bitter, P Czobor, A Borsi, L Fehér, B Z Nagy, M Bacskai, P Rakonczai, R Hegyi, T Németh, P Varga, J Gimesi-Országh, P Fadgyas-Freyler, J Sermon, P Takács
AIM: We conducted a matched-cohort study to assess mortality in schizophrenia and the relationship of mortality with comorbid somatic conditions and suicide attempts. METHOD: A full-population register-based prospective matched-cohort study was performed including all eligible patients with schizophrenia in Hungary between 01/01/2005 and 31/12/2013. Control subjects were individually matched to patients with schizophrenia at a 5:1 ratio. The principal outcome measure was death due to any reason...
June 12, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28740825/nmdar-hypofunction-and-somatostatin-expressing-gabaergic-interneurons-and-receptors-a-newly-identified-correlation-and-its-effects-in-schizophrenia
#16
REVIEW
Fatemah Alherz, Mohammad Alherz, Hashemiah Almusawi
This review investigates the association between N-methyl-d-Aspartate receptor (NMDAR) hypofunction and somatostatin-expressing GABAergic interneurons (SST +) and how it contributes to the cognitive deficits observed in schizophrenia (SZ). This is based on evidence that NMDAR antagonists caused symptoms resembling SZ in healthy individuals. NMDAR hypofunction in GABAergic interneurons results in the modulation of the cortical network oscillation, particularly in the gamma range (30-80 Hz). These gamma-band oscillation (GBO) abnormalities were found to lead to the cognitive deficits observed in the disorder...
June 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28730225/purkinje-cells-pathology-in-schizophrenia-a-morphometric-approach
#17
Ioannis Asterios Mavroudis, Foivos Petrides, Marina Manani, Fotios Chatzinikolaou, Alin Stelian Ciobică, Manuela Pădurariu, Dimitrios Kazis, Samuel Ndugu Njau, Vasiliki George Costa, Stavros John Baloyannis
OBJECTIVES: Schizophrenia is a brain disorder that affects more than 21 million people worldwide. Ventricle enlargement and reduction in the volume of the temporal lobe overall and in medial temporal structures constitutes the main macroscopic findings, whilst synaptic and spinal changes as well as gliosis in the hippocampal formation, the prefrontal and the entorhinal cortex stand among cardinal microscopic findings in the schizophrenic brains. In recent years, accumulated evidence comes to light about the role of cerebellum in the pathophysiology of schizophrenia...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28725951/new-aspects-of-the-vulnerability-stress-model-in-general-its-relevance-in-schizophrenic-psychoses-and-the-place-of-antipsychotics
#18
EDITORIAL
Hans-Jürgen Möller
No abstract text is available yet for this article.
July 19, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28718988/hydrogels-with-dual-thermoresponsive-mechanical-performance
#19
Hui Guo, Cécile Mussault, Alba Marcellan, Dominique Hourdet, Nicolas Sanson
Dual thermoresponsive chemical hydrogels, combining poly(N-isopropylacrylamide) side-chains within a poly(N-acryloylglycinamide) network, are designed following a simple and versatile procedure. These hydrogels exhibit two phase transitions both at low (upper critical solution temperature) and high (lower critical solution temperature) temperatures, thereby modifying their swelling, rheological, and mechanical properties. These novel thermo-schizophrenic hydrogels pave the way for the development of thermotoughening wet materials in a broad range of temperatures...
July 18, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28713691/cognitive-correlates-of-neuroimaging-abnormalities-in-the-onset-of-schizophrenia-a-case-report
#20
Silvia Grassi, Giulia Orsenigo, Marta Serati, Elisabetta Caletti, Alfredo Carlo Altamura, Massimiliano Buoli
Increasing evidence shows that cognitive impairment and brain abnormalities can appear early in the first episodes of schizophrenia, but it is currently debated how brain changes can correlate with clinical presentation of schizophrenic patients. Of note, this report describes the case of a young schizophrenic male presenting parietal magnetic resonance/positron emission tomography abnormalities and cognitive impairment, documented by specific neuropsychological tests. In our knowledge only few studies have investigated if neuropsychological abnormalities could be concomitant with both structural and functional neuroimaging...
June 22, 2017: World Journal of Psychiatry
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