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https://www.readbyqxmd.com/read/28444578/experimental-psychosis-research-and-schizophrenia-similarities-and-dissimilarities-in-psychopathology
#1
Leo Hermle, Rainer Kraehenmann
The aim of experimental psychopathology is to delineate overlapping functional disorders of psychoneurobiologically-defined systems where a set of common symptoms may correspond to a variety of nosological entities. According to the vulnerability model of psychosis, experimental research needs to go beyond categories such as "schizophrenia". Prospective studies of the effects of psychoactive substances in normal control subjects offer several methodological advantages over routine clinical reviews of schizophrenic patients, especially in terms of standardization...
April 26, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#2
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28436782/subverting-space-an-exploration-of-a-dance-therapy-workshop-apparatus-for-schizophrenics
#3
Silvia Lippi, Laetitia Petit
The authors created a dance workshop for schizophrenic patients designed to address their singular experience of space, in which the categories of interior and exterior do not function as limits. The space of the workshop, which, paradoxically, is thought in terms of the psychic space of schizophrenic patients by playing on its borderless quality, creates a continuity between the psychiatric hospital and the external world, and thus helps to prevent the segregation and isolation of such patients. This continuity is established on the basis of both the physical architecture of the workshop setting and the practice of dancing itself...
April 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/28429899/neurotransmitter-systems-neuroanatomical-pathology-and-cell-death-in-schizophrenia-update-and-perspectives
#4
Hazael Avila-Rojas, Hugo Sandoval-Zamora, Iván Pérez-Neri
Schizophrenia is a thought disorder characterized by delusional thinking which may be accompanied by hallucinations involving any sensory modality. Schizophrenia may be associated with several neurologic and psychiatric disorders. Also, it may be induced by drugs. In spite of the similarity in psychoses symptomatology, it is unknown if it involves the same underlying neurobiologic mechanisms in those cases. Schizophrenic patients exhibit not only neuroanatomical alterations, but also, distortion of several neurotransmitter systems...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28422427/is-motor-imagery-different-in-catatonic-schizophrenia
#5
Yuliya Zaytseva, Alexandra Morozova, Marie Bendova, Zhanna Garakh
Catatonic schizophrenia, a rare subtype in this disease group, is characterized by motor disturbances. The current study investigated the reactivity of electroencephalographic mu rhythm in a motion imagery task in two single cases of first-episode catatonic schizophrenia, assuming they would show less mu rhythm reduction compared to paranoid schizophrenic patients and healthy controls.
April 19, 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28418833/willingness-to-pay-in-caregivers-of-patients-affected-by-schizophrenia
#6
Claudiane Salles Daltio, Cecilia Attux, Marcos Bosi Ferraz
BACKGROUND: Schizophrenia is a debilitating disorder that often requires the affected individual to receive care from a caregiver. Willingness to Pay (WTP) technique allows a valuation of the health state preferences by assessing the impact of the disease and translating it into monetary terms. AIMS OF THE STUDY: The objective was to determine the WTP of schizophrenic patients' caregivers on a hypothetical recovery scenario and correlate it to socio-demographic and clinical characteristics, Knowledge of Disease, Quality of life and Burden of Disease...
March 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#7
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28403847/erratum-to-brain-structure-differences-among-male-schizophrenic-patients-with-history-of-serious-violent-acts-an-mri-voxel-based-morphometric-study
#8
Noriomi Kuroki, Hiroko Kashiwagi, Miho Ota, Masanori Ishikawa, Hiroshi Kunugi, Noriko Sato, Naotsugu Hirabayashi, Toshio Ota
No abstract text is available yet for this article.
April 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28399850/psychometric-characteristics-of-the-general-oral-health-assessment-index-gohai-%C3%A2-in-a-french-representative-sample-of-patients-with-schizophrenia
#9
Frederic Denis, Mohamad Hamad, Benoit Trojak, Stéphanie Tubert-Jeannin, Corinne Rat, Jean-François Pelletier, Nathalie Rude
BACKGROUND: The "General Oral Health Assessment Index" (GOHAI) was widely used in clinical or epidemiological studies worldwide, as it was available for use in different languages. Therefore, the aim of this study was to evaluate the psychometric characteristics of the GOHAI in a representative sample of patients with schizophrenia. METHODS: A total of 90 schizophrenic patients (in-patients and out-patients) were recruited from the participants of the "buccodor study" (NCT02167724) between March and September 2015...
April 11, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28393745/correlation-of-reduced-social-communicational-and-interactional-skills-with-regional-grey-matter-volumes-in-schizophrenia-patients
#10
Miho Ota, Junko Matsuo, Noriko Sato, Toshiya Teraishi, Hiroaki Hori, Kotaro Hattori, Yoko Kamio, Hiroshi Kunugi
OBJECTIVE: Recent studies have detected similarities between autism spectrum disorder and schizophrenia. We investigated structural abnormalities associated with autistic-like traits in patients with schizophrenia by voxel-based morphometry. METHODS: Patients with schizophrenia and healthy subjects were evaluated by the adult version of the social responsiveness scale (SRS-A), which is sensitive to autistic traits and symptoms even under subthreshold conditions, and magnetic resonance imaging...
April 10, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28393621/a-review-on-the-relationship-between-gluten-and-schizophrenia-is-gluten-the-cause
#11
Can Ergün, Murat Urhan, Ahmet Ayer
INTRODUCTION: Schizophrenia is a chronic disease that possesses various clinical manifestations. It presents rather heterogeneous characteristics with respect to onset type, symptoms, and the course of the disease. Although the lifetime prevalence is as low as 1%, it can cause serious disability. Thus, it is very important to develop efficient treatment methods. In some studies, it is hypothesized that removing gluten from the diet leads to a significant improvement in disease symptoms...
April 9, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28392697/comparing-the-ability-of-cognitive-and-affective-theory-of-mind-in-adolescent-onset-schizophrenia
#12
Dandan Li, Xiaosi Li, Fengqiong Yu, Xingui Chen, Long Zhang, Dan Li, Qiang Wei, Qing Zhang, Chunyan Zhu, Kai Wang
BACKGROUND: Evidence in the literature suggests that there is an impairment of social cognition in schizophrenia. Theory of Mind (ToM) is defined as one's ability to understand others' wishes, beliefs, intentions, and other psychological states and thereby to judge others' behavior, as an essential component of social cognition. However, there have been limited studies on social cognition, especially ToM in adolescent onset schizophrenia (AOS). The current study aims to investigate ToM abilities in adolescent schizophrenia according to various ToM subcomponents (cognitive ToM and affective ToM) and various ToM orders (first order and second order)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28392209/verbal-working-memory-in-schizophrenia-the-role-of-syntax-in-facilitating-serial-recall
#13
Adrienne W Y Li, Nestor Viñas-Guasch, Christy L M Hui, Wing-Chung Chang, Sherry K W Chan, Edwin H M Lee, Eric Y H Chen
BACKGROUND: Deficits in verbal working memory (VWM) have consistently been observed in schizophrenia, ranging from impairments in capacity, encoding, to irregular semantic organisation. However, syntactic deficits are less well-characterised, despite its crucial role in language construction. This study examines the role of simple syntactic structure (basis of the "sentence superiority effect") in VWM of patients with psychotic disorders. METHODS: Patients with schizophrenia-spectrum disorders (n=40) and healthy controls matched on age, sex and education (n=40) were administered an auditory serial recall task containing word lists with low semantic coherence and either syntactically familiar structure (noun-verb-noun sequence) or syntactically unfamiliar structure...
April 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28385625/alpha-oscillations-underlie-working-memory-abnormalities-in-the-psychosis-high-risk-state
#14
Avinash Ramyead, Michael Kometer, Erich Studerus, Denise Baumeler, Robin von Rotz, Anita Riecher-Rössler
Working memory (WM) functioning, known to be modulated by neural oscillations, is impaired in schizophrenic psychoses. It remains unclear whether in the psychosis high-risk state, WM encoding is altered or whether patients are impaired at shielding their WM against distractors. We employed single-trial analyses of neurophysiological and behavioral data recorded during a WM paradigm, designed to include predictable distractors, on 18 patients with an at-risk mental state for psychosis (ARMS, 26.1±5.45 years) and 21 healthy controls (HCs, 25...
April 3, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28385492/reduced-white-matter-integrity-and-facial-emotion-perception-in-never-medicated-patients-with-first-episode-schizophrenia-a-diffusion-tensor-imaging-study
#15
Xiaoxin Zhao, Yuxiu Sui, Jingjing Yao, Yiding Lv, Xinyue Zhang, Zhuma Jin, Lijun Chen, Xiangrong Zhang
BACKGROUND: Facial emotion perception is impaired in schizophrenia. Although the pathology of schizophrenia is thought to involve abnormality in white matter (WM), few studies have examined the correlation between facial emotion perception and WM abnormalities in never-medicated patients with first-episode schizophrenia. The present study tested associations between facial emotion perception and WM integrity in order to investigate the neural basis of impaired facial emotion perception in schizophrenia...
April 4, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28382934/connecting-myelin-related-and-synaptic-dysfunction-in-schizophrenia-with-snp-rich-gene-expression-hubs
#16
Hedi Hegyi
Combining genome-wide mapping of SNP-rich regions in schizophrenics and gene expression data in all brain compartments across the human life span revealed that genes with promoters most frequently mutated in schizophrenia are expression hubs interacting with far more genes than the rest of the genome. We summed up the differentially methylated "expression neighbors" of genes that fall into one of 108 distinct schizophrenia-associated loci with high number of SNPs. Surprisingly, the number of expression neighbors of the genes in these loci were 35 times higher for the positively correlating genes (32 times higher for the negatively correlating ones) than for the rest of the ~16000 genes...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378228/inflammatory-processes-and-schizophrenia-two-independent-lines-of-evidence-from-a-study-of-twins-discordant-and-concordant-for-schizophrenic-disorders
#17
Silke Braun, René Bridler, Norbert Müller, Markus J Schwarz, Erich Seifritz, Matthias Weisbrod, Alexandra Zgraggen, Hans H Stassen
The concept of twin concordance involves quantifying the resemblance between co-twins in an "objective" and reproducible way. Yet, quantifying resemblance in the case of complex psychiatric traits like schizophrenic disorders leads to methodological problems, as the yes-no dichotomy of diagnostic schemata does not allow one to assess between-subject differences in psychopathology patterns sufficiently accurately. Therefore, we relied on a multidimensional, quantitative concordance measure that provided a high resolution and differentiation when assessing the resemblance of psychopathology patterns...
April 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28374697/-a-differential-approach-to-the-improvement-of-prevention-and-correction-of-neuroleptic-side-extrapyramidal-disorders-with-pantogam-activ-in-patients-with-schizophrenia
#18
A S Tiganov, G P Panteleeva, L I Abramova, P V Bologov, P S Kananovich, M A Omel'chenko, I Yu Nikiforova
AIM: To assess the efficacy and safety of pantogam active (PA) in prevention and correction of neurological side-effects during the course neuroleptic treatment of acute endogenous psychoses. MATERIAL AND METHODS: Eighty schizophrenic patients (mean age 33 years) with acute psychosis were examined. All patients received 28-day course treatment with typical and atypical neuroleptics. Two equal groups were studied: patients of the first group were treated with trihexyphenidyl (THP) in dose of 0,002-0,012 mg and patients of the second group received in addition PA in dose 0,9 mg/day...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28374670/the-effect-of-ibuprofen-on-cytokine-production-by-mononuclear-cells-from-schizophrenic-patients
#19
H Bessler, D Cohen-Terica, M Djaldetti, P Sirota
The existence of a restrained inflammatory state in schizophrenic individuals posed the question whether anti-inflammatory drugs may exert antipsychotic effects. Therefore, the effect of ibuprofen (IB) on cytokine production by human peripheral blood mononuclear cells (PBMC) from schizophrenic patients was examined and compared to that of healthy subjects. PBMC from 25 schizophrenic patients and 24 healthy volunteers were incubated for 24 h with lipopolysaccharide (LPS) in the absence or presence of various concentrations of IB...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28371955/-illness-concepts-of-patients-with-schizophrenia-a-triangulation-study
#20
Moritz E Wigand, Lea Reichhardt, Fabian U Lang, Silvia Krumm, Markus Jäger
Objective Therapists' and patients' concepts of illness often show severe discrepancies. This study explores the illness concepts of patients with schizophrenic disorders (n = 40). Methods Two German scales were used, the "Causal Belief Questionnaire" and the "Illness Concept Scale for Schizophrenic Patients". We compared our data with data published previously. A semi structured interview was performed in a convenience sample (n = 7). Results The domains "trust in medication" and "trust in the treating physician" yielded high scores, yet in comparison with data published 30 years ago, trust in medication is unaltered, while trust in psychiatrists is even slightly lower...
April 3, 2017: Psychiatrische Praxis
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