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https://www.readbyqxmd.com/read/29791666/prevalence-of-polymorphisms-in-the-ankk1-drd2-drd3-genes-and-metabolic-syndrome-in-refractory-schizophrenia
#1
Jeizziani Aparecida Ferreira Pinto, Pedro Henrique Batista de Freitas, Fernanda Daniela Dorneles Nunes, Paulo Afonso Granjeiro, Luciana Lara Dos Santos, Richardson Miranda Machado
OBJECTIVE: to estimate the prevalence of TaqIA, -141C and rs6280 polymorphisms of the ANKK1, DRD2 and DRD3 genes and evaluate their association with the occurrence of metabolic syndrome in patients with refractory schizophrenia. METHOD: cross-sectional study conducted in the Extended Western Region of Minas Gerais, with refractory schizophrenic patients using the antipsychotic clozapine. Sociodemographic, clinical, anthropometric, biochemical and genetic data were collected...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29783976/possible-multiple-system-atrophy-with-predominant-parkinsonism-in-a-patient-with-chronic-schizophrenia-a-case-report
#2
Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono, Yoshihisa Kakuto
BACKGROUND: Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is categorized as MSA-P with predominant parkinsonism, and as MSA-C with predominant cerebellar features. The prevalence of MSA has been reported to be between 1.86 and 4.9 cases per 100,000 individuals. In contrast, approximately 1% of the population is affected by schizophrenia during their lifetime; therefore, MSA-P comorbidity is very rare in schizophrenic patients...
May 21, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29777287/decreased-plasma-levels-of-gasotransmitter-hydrogen-sulfide-in-patients-with-schizophrenia-correlation-with-psychopathology-and-cognition
#3
Jian-Wen Xiong, Bo Wei, Yan-Kun Li, Jin-Qiong Zhan, Shu-Zhen Jiang, Hai-Bo Chen, Kun Yan, Bin Yu, Yuan-Jian Yang
OBJECTIVE: Aberrant N-methyl-D-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. Hydrogen sulfide (H2 S) is an endogenous gasotransmitter that regulates NMDAR function. The current study investigated the relationship between plasma H2 S levels and both psychopathological and cognitive symptoms in schizophrenia. MATERIALS AND METHODS: Forty-one patients with schizophrenia and 40 healthy control subjects were recruited in present study...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29771703/a-fatal-outcome-of-pica-syndrome-an-unusual-case-of-delayed-mortality
#4
Milenko Bogdanovic, Djordje Alempijevic, Djordje Curcic, Tijana Durmic
We present the case of a 42-year-old man, with a medical history of schizophrenic psychosis, who was found dead on the floor of his bedroom. At the autopsy, a bottle lid with a notched edge was found in the lower pharynx, partially obstructing the larynx and thus keeping the epiglottis in an open position. Airway obstruction was caused by edema and inflammation of the surrounding tissue. After removal of the foreign body, the tissue of the larynx was left with an impression of the bottle lid. The adjacent mucosa was swollen, hyperemic, partly necrotic, and covered with fibrin deposits...
May 16, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29766281/sex-and-gender-differences-in-schizophrenic-psychoses-a-critical-review
#5
Anita Riecher-Rössler, Surina Butler, Jayashri Kulkarni
Many sex and gender differences in schizophrenic psychoses have been reported, but few have been soundly replicated. A stable finding is the later age of onset in women compared to men. Gender differences in symptomatology, comorbidity, and neurocognition seem to reflect findings in the general population. There is increasing evidence for estrogens being psychoprotective in women and for hypothalamic-pituitary-gonadal dysfunction in both sexes.More methodologically sound, longitudinal, multi-domain, interdisciplinary research investigating both sex (biological) and gender (psychosocial) factors is required to better understand the different pathogenesis and etiologies of schizophrenic psychoses in women and men, thereby leading to better tailored treatments and improved outcomes...
May 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29763843/mutation-analysis-of-the-wnt7a-gene-in-patients-with-schizophrenia
#6
Tsung-Ming Hu, Lieh-Yung Ping, Shih-Hsin Hsu, Hsin-Yao Tsai, Min-Chih Cheng
Aberrant WNT signaling has been implicated in the pathophysiology of schizophrenia. WNT7A, a member of the WNT gene family, is considered a potential candidate of schizophrenia. All exons of WNT7A in 570 schizophrenic patients and 563 controls were sequenced, and protein functional analysis was conducted. Five common variants were identified, but none were noted to be associated with schizophrenia. Nevertheless, nine rare mutations, including one schizophrenia-specific missense mutation (c.305G > A), were discovered...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29754115/delusional-misidentifications-in-a-procrustean-bed
#7
EDITORIAL
G N Christodoulou, M Margariti, N Christodoulou
The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally fused functions of perception and recognition. The classical sub-types are: the syndromes of Capgras, Fregoli,Intermetamorphosis (mentioned in 3) and Subjective doubles. These syndromes occur in a clear sensorium and shouldbe differentiated from the banal transient misidentifications occurring in confusional states and in mania and from thenon-delusional misidentifications (e...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29736883/abnormalities-of-regional-homogeneity-and-its-correlation-with-clinical-symptoms-in-na%C3%A3-ve-patients-with-first-episode-schizophrenia
#8
Xiaoxin Zhao, Jingjing Yao, Yiding Lv, Xinyue Zhang, Chongyang Han, Lijun Chen, Fangfang Ren, Zhuma Jin, Yuan Li, Yuxiu Sui
Several resting-state neuroimaging studies have indicated abnormal regional homogeneity (ReHo) in chronic schizophrenia; however, little work has been conducted to investigate naïve patients with first-episode schizophrenia (FES). Even less investigated is the association between ReHo measures and clinical symptom severity in naïve patients with FES. The current study evaluated ReHo alterations in whole brain, and assessed the correlations between ReHo measures and clinical variables in naïve patients with FES...
May 7, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29734128/obstetric-and-perinatal-health-outcomes-related-to-schizophrenia-a-national-register-based-follow-up-study-among-finnish-women-born-between-1965-and-1980-and-their-offspring
#9
Laura Simoila, Erkki Isometsä, Mika Gissler, Jaana Suvisaari, Erja Halmesmäki, Nina Lindberg
BACKGROUND: This national register-based study assesses obstetric and perinatal health outcomes in women with schizophrenia and their offspring. METHODS: Using the Care Register for Health Care, we identified Finnish women who were born in 1965- 1980 and diagnosed with schizophrenia. For each case, five age- and place-of-birth- matched controls were obtained from the Central Population Register of Finland. They were followed from the day when the disorder was diagnosed in specialized health-care (the index day) until 31...
May 4, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29732230/strangulation-of-the-penis-by-a-metallic-ring-prevention-is-better-than-cure
#10
Hamza Ichaoui, Sataa Sallami, Ahmed Samet, Zied Bokal, Hassan Touinsi
Strangulation of the penis is a rare condition that requires emergency management. Several objects, metallic or not, can be placed on the penis to increase sexual performance or for self-erotic intentions especially in psychotic patients with unusual sexual impulses. The problem of removing the foreign body and repairing the damage is a real challenge for the practitioner and a great stress for the patient. We report a case of a 42-year-old schizophrenic patient who presented to the emergency department for a strangulation of the penis secondary to a metal ring placed at the base of the penis 10 days before the consultation without urinary disorder...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29731930/the-comparison-of-olanzapine-and-risperidone-treatment-in-male-schizophrenic-patients-using-positive-and-negative-syndromes-scale-panss
#11
Endah Tri Lestari, Elmeida Effendy, Mustafa Mahmud Amin, Bahagia Loebis
INTRODUCTION: The most common method to compare olanzapine and risperidone is by calculating the score of positive and negative syndromes scale (PANSS). However, there were some conflicting results mentioned from previous studies. AIM: This study aimed to compare the treatment of olanzapine and risperidone using PANSS, limited to only male patients receiving inpatient treatment to obtain more significant results. METHODS: The subjects of this study were male schizophrenic patients in the acute phase of treatment (N = 68) who were hospitalised at the Mental Hospital Prof...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29730045/improving-cognitive-training-for-schizophrenia-using-neuroplasticity-enhancers-lessons-from-decades-of-basic-and-clinical-research
#12
G D Guercio, M E Thomas, J M Cisneros-Franco, P Voss, R Panizzutti, E de Villers-Sidani
Mounting evidence indicates that schizophrenia is a disorder that stems from maladaptive plasticity within neural circuits and produces broad cognitive deficits leading to loss of autonomy. A large number of studies have identified abnormalities spanning many neurotransmitter systems in schizophrenia, and as a result, a variety of drugs have been developed to attempt to treat these abnormalities and enhance cognition. Unfortunately, positive results have been limited so far. This may be in part because the scope of abnormalities in the schizophrenic brain requires a treatment capable of engaging many different neurotransmitter systems...
May 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29729395/contribution-of-induced-pluripotent-stem-cell-technologies-to-the-understanding-of-cellular-phenotypes-in-schizophrenia
#13
REVIEW
Shabeesh Balan, Manabu Toyoshima, Takeo Yoshikawa
Schizophrenia is one of the leading causes of disability among mental disorders, contributing to a substantial socioeconomic burden. Our understanding of the mechanisms of the pathogenesis of the disease has largely been limited by its inherent complexity imparted by the polygenicity and interactions with environmental factors. Since pathobiological events are initiated in the schizophrenic brain long before the onset of the psychotic manifestations, characterizing these processes is limited, mainly due to a lack of access to neuronal tissues...
May 2, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29728866/pregnancy-in-women-with-psychotic-disorders-risk-factors-associated-with-mother-baby-separation
#14
Agathe Cès, Bruno Falissard, Nine M C Glangeaud-Freudenthal, Anne-Laure Sutter-Dallay, Florence Gressier
Pregnancy in women suffering from psychotic disorders is becoming more common. However, this psychiatric disorder is linked to the highest risk of early mother and child separation. The aim of this study was to evaluate risk factors associated with these separations. In an observational, naturalist, and multicentric study, 320 women suffering from a psychotic disorder and jointly hospitalized with their child in one of the sixteen mother-baby units (MBUs) in France and Belgium between 2001 and 2010 were assessed for risk factors associated with mother-child separation...
May 4, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29723454/-aripiprazole-for-drug-induced-sexual-dysfunction-in-schizophrenic-males
#15
Li-Juan Gao, Hua-Gui Guo, Zhen-Tao Liang, Xiao-Xiao Zhong, Jin-Cai Zhu, Yu Yang
Objective: To investigate the clinical effects of aripiprazole on sexual dysfunction induced by amisulpride or risperidone in male patients with schizophrenia. METHODS: This study included 75 male patients with drug-induced secondary sexual dysfunction after treated with amisulpride or risperidone for first-episode schizophrenia between October 2014 and October 2016. We substituted aripiprazole for amisulpride or risperidone, gradually increased the dose from 10 to 30 mg/d within 2 weeks, and maintained 30 mg/d from the 3rd week...
July 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29719356/defects-of-gamma-oscillations-in-auditory-steady-state-evoked-potential-of-schizophrenia
#16
Chenhui Sun, Ping Zhou, Changming Wang, Yu Fan, Qing Tian, Fang Dong, Fuchun Zhou, Chuanyue Wang
Background: Patients with schizophrenia have many cognitive deficits. Gamma oscillations exist in the human brain and are closely related to neurocognition. Auditory Steady-State Responses (ASSRs) is an electroneurophysiological index that could reflect gamma oscillations. It was found that the energy evoked by 40 Hz ASSRs in schizophrenic patients was significantly lower than that in healthy subjects. However, the correlation between ASSRs phase index and clinical symptoms and neurocognitive deficits has yet to be systematically studied...
February 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29710513/alterations-in-oxidative-stress-markers-and-its-correlation-with-clinical-findings-in-schizophrenic-patients-consuming-perphenazine-clozapine-and-risperidone
#17
Narjes Hendouei, Samaneh Farnia, Farhad Mohseni, Azadeh Salehi, Maedeh Bagheri, Faezeh Shadfar, Fatemeh Barzegar, Seyed Davood Hoseini, Jamshid Yazdani Charati, Fatemeh Shaki
BACKGROUND AND OBJECTIVE: Today, the role of oxidative stress in development of schizophrenia has gained attention. Also, some atypical antipsychotic agents showed antioxidant properties. Therefore, in this study, we evaluated the level of oxidative stress parameters between patients treated with perphenazine, clozapine and risperidone and their relationship with schizophrenia symptoms' severity. MATERIALS AND METHODS: This was a descriptive study on 100 patients with chronic schizophrenia...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29701937/mediation-analyses-of-insight-quality-of-life-depression-and-suicidality-results-from-the-face-sz-cohort
#18
Paul Roux, David Misdrahi, Delphine Capdevielle, Bruno Aouizerate, Fabrice Berna, Lore Brunel, Isabelle Chereau, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget-Agius, Sandrine Fonteneau, Franck Gabayet, Pierre Michel Llorca, Jasmina Mallet, Romain Rey, Raphaëlle Richieri, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Pierre Vidailhet, Christine Passerieux, Mathieu Urbach
OBJECTIVE: The relationship between greater insight and increased risk of suicide in patients with schizophrenia is debated. The purpose of this study was to assess whether quality of life (QoL) and depression mediated the association between insight and suicidality. METHODS: Between March 2010 and December 2015, 527 community-dwelling adults with stable schizophrenia according to DSM-IV criteria were included in a multicenter cross-sectional study, the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29691943/distinguishable-brain-networks-relate-disease-susceptibility-to-symptom-expression-in-schizophrenia
#19
Zhaowen Liu, Jie Zhang, Kai Zhang, Junying Zhang, Xiaojing Li, Wei Cheng, Mingli Li, Liansheng Zhao, Wei Deng, Wanjun Guo, Xiaohong Ma, Qiang Wang, Paul M Matthews, Jianfeng Feng, Tao Li
Disease association studies have characterized altered resting-state functional connectivities describing schizophrenia, but failed to model symptom expression well. We developed a model that could account for symptom severity and meanwhile relate this to disease-related functional pathology. We correlated BOLD signal across brain regions and tested separately for associations with disease (disease edges) and with symptom severity (symptom edges) in a prediction-based scheme. We then integrated them in an "edge bi-color" graph, and adopted mediation analysis to test for causality between the disease and symptom networks and symptom scores...
April 24, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29686254/the-relationship-between-dopamine-receptor-blockade-and-cognitive-performance-in-schizophrenia-a-11-c-raclopride-pet-study-with-aripiprazole
#20
Sangho Shin, Seoyoung Kim, Seongho Seo, Jae Sung Lee, Oliver D Howes, Euitae Kim, Jun Soo Kwon
Aripiprazole's effects on cognitive function in patients with schizophrenia are unclear because of the difficulty in disentangling specific effects on cognitive function from secondary effects due to the improvement in other schizophrenic symptoms. One approach to address this is to use an intermediate biomarker to investigate the relationship between the drug's effect on the brain and change in cognitive function. This study aims to investigate aripiprazole's effect on working memory by determining the correlation between dopamine D2/3 (D2/3) receptor occupancy and working memory of patients with schizophrenia...
April 24, 2018: Translational Psychiatry
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