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https://www.readbyqxmd.com/read/30077175/structure-based-design-of-some-isonicotinic-acid-hydrazide-analogues-as-potential-antitubercular-agents
#1
Amal Atta, Salwa Fahmy, Ola Rizk, Dharmarajan Sriram, Mona A Mahran, Ibrahim M Labouta
New pyridine derivatives were designed and synthesized as Isonicotinic acid hydrazide (INH) analogues. The synthesized compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis strain H37 Rv . Ten compounds (3c, 3e-g, 5a-c, 6h, 10 and 11b) showed promising antitubercular activity with MIC range 7.30 µM-19.39 µM. Compounds 3e, 3g, 5b and 11b were the most potent analogues, with MIC 7.30-8.74 µM. They were equipotent to the standard drug Ethambutol (MIC 7.64 µM) and more active than the standard drug Pyrazinamide (MIC 50...
July 27, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29798217/-enviroment-control-and-healthy-education-the-most-important-methods-for-treatment-of-allergic-rhinitis
#2
H T Wang, Y N Wang
No abstract text is available yet for this article.
September 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29715674/experimental-studies-on-the-enhanced-performance-of-lightweight-oil-recovery-using-a-combined-electrocoagulation-and-magnetic-field-processes
#3
Yang Liu, Jie Yang, Wenming Jiang, Yimei Chen, Chaojiang Yang, Tianyu Wang, Yuxing Li
On marine oil spill, inflammable lightweight oil has characteristics of explosion risk and contamination of marine enviroment, therefore treatment of stable emulsion with micron oil droplets is urgent. This study aimed to propose a combined electrocoagulation and magnetic field processes to enhance performance of lightweight oil recovery with lower energy consumption. The effects of current density, electrolysis time, strength and direction of magnetic field on the overall treatment efficiency of the reactor were explored...
August 2018: Chemosphere
https://www.readbyqxmd.com/read/29500264/efficacy-of-a-sonicating-swab-for-removal-and-capture-of-microorganisms-from-experimental-and-natural-contaminated-surfaces
#4
Gianna P Ahnrud, Alma J Mendoza, Matthew J Hurley, Patrick J Marek
Enhancements in swabbing technology to increase sample collection efficacy would benefit the food industry. Specifically, these enhancements would assist the food industry in implementing the FDA Food Safety Modernization Act (FSMA) requirements by improving environmental monitoring effectiveness. A sonicating swab device, an example of an enhanced swabbing technology, was demonstrated previously to remove biofilm from stainless steel more efficiently than a standard cotton swab. Within this study, the performance of the sonicating swab was compared to that of the standard cotton swab for the recovery of Listeria monocytogenes from inoculated surfaces (plastic cutting board, wood cutting board, vinyl floor tile, and quarry clay floor tile)...
May 1, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29470766/haloperidol-attenuates-methylphenidate-and-modafinil-induced-behavioural-sensitization-and-cognitive-enhancement
#5
Nausheen Alam, Kulsoom Choudhary
Previous studies have demonstrated that repeated psychostimulant administration produces behavioural sensitization and cognitive tolerance. Brain dopaminergic system and the involvement of dopamine D2 -receptors are considered to be important in psychostimulant-induced sensitization. Study designed to compared the motor activity by using familiar and novel enviroments and cognitive effects by water maze and passive avoidance test after long term administration of methylphenidate(at the dose 0.6 mg/kg/day, 2...
June 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29332595/new-bis-pyrazolones-as-potential-leads-for-ros-inhibition-environment-friendly-green-synthesis-structural-characterization-and-in-vitro-studies
#6
Sahar Yousuf, Khalid M Khan, Uzma Salar, Almas Jabeen, Shakil Ahmed, Munira T Muhammad, Aisha Faheem, Shahnaz Perveen
BACKGROUND: Pyrazolones have identified as significant antioxidant agents and many marketed and clinically prescribed NSAIDs have pyrazolone ring as main scaffold. METHOD: Keeping in consideration the antioxidant potential of pyrazolone scaffold, new bispyrazolones 3-30 were synthesized by a green and enviroment friendly reaction route, in which two equivalents of 1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-ol were treated with one equivalent of benzaldehyde derivatives without any catalyst...
2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29293842/spatially-resolved-elemental-analysis-spectroscopy-and-diffraction-at-the-gsecars-sector-at-the-advanced-photon-source
#7
Stephen R Sutton, Antonio Lanzirotti, Matthew Newville, Mark L Rivers, Peter Eng, Liliana Lefticariu
X-ray microprobes (XRM) coupled with high-brightness synchrotron X-ray facilities are powerful tools for environmental biogeochemistry research. One such instrument, the XRM at the Geo Soil Enviro Center for Advanced Radiation Sources Sector 13 at the Advanced Photon Source (APS; Argonne National Laboratory, Lemont, IL) was recently improved as part of a canted undulator geometry upgrade of the insertion device port, effectively doubling the available undulator beam time and extending the operating energy of the branch supporting the XRM down to the sulfur K edge (2...
November 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/29291459/autochthonous-facility-specific-microbiota-dominates-washed-rind-austrian-hard-cheese-surfaces-and-its-production-environment
#8
Narciso M Quijada, Evelyne Mann, Martin Wagner, David Rodríguez-Lázaro, Marta Hernández, Stephan Schmitz-Esser
Cheese ripening involves the succession of complex microbial communities that are responsible for the organoleptic properties of the final products. The food processing environment can act as a source of natural microbial inoculation, especially in traditionally manufactured products. Austrian Vorarlberger Bergkäse (VB) is an artisanal washed-rind hard cheese produced in the western part of Austria without the addition of external ripening cultures. Here, the composition of the bacterial communities present on VB rinds and on different processing surfaces from two ripening cellars was assessed by near full length 16S rRNA gene amplification, cloning and sequencing...
February 21, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29265852/a-social-identity-model-of-pro-environmental-action-simpea
#9
Immo Fritsche, Markus Barth, Philipp Jugert, Torsten Masson, Gerhard Reese
Large-scale environmental crises are genuinely collective phenomena: they usually result from collective, rather than personal, behavior and how they are cognitively represented and appraised is determined by collectively shared interpretations (e.g., differing across ideological groups) and based on concern for collectives (e.g., humankind, future generations) rather than for individuals. Nevertheless, pro-environmental action has been primarily investigated as a personal decision-making process. We complement this research with a social identity perspective on pro-environmental action...
March 2018: Psychological Review
https://www.readbyqxmd.com/read/29216210/social-relationship-changes-in-victim-families-due-to-a-social-disaster-experiences-of-student-victims-families-in-the-south-korean-sewol-ferry-disaster
#10
Sun Mi Cho, Ansuk Jeong, Jung Hee Ha, Eun Young Kim
The Sewol ferry incident on April 16, 2014 in South Korea claimed the lives of 304 individuals, including about 250 high school students on a school trip. The majority of South Korean citizens were watching live updates on the capsized Sewol ferry, anxiously watching on TV how the vessel fully sunk over time. They were desperately hoping for the rescue of the survivors inside. However, their anxiety had become shock, anger, and helplessness, and the disaster has become a daunting, collective trauma, not just to the victims and their families, but also to the citizens who were exposed only through the media...
2017: PloS One
https://www.readbyqxmd.com/read/29150766/spinobot-an-mri-guided-needle-positioning-system-for-spinal-cellular-therapeutics
#11
Alexander Squires, John N Oshinski, Nicholas M Boulis, Zion Tsz Ho Tse
The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results in the death of motor neurons in voluntary muscles. There are no cures for ALS and few available treatments. In studies with small animal models, injection of cellular therapeutics into the anterior horn of the spinal cord has been shown to inhibit the progression of ALS. It was hypothesized that spinal injection could be made faster and less invasive with the aid of a robot. The robotic system presented-SpinoBot-uses MRI guidance to position a needle for percutaneous injection into the spinal cord...
March 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29108247/regulator-of-g-protein-signaling-4-inhibits-human-melanoma-cells-proliferation-and-invasion-through-the-pi3k-akt-signaling-pathway
#12
Xiaotong Xue, Lihua Wang, Xianguang Meng, Jing Jiao, Ningning Dang
Melanoma is a tumor produced by skin melanocytes, which has a high metastatic rate and poor prognosis. So far, plenty of work has been done on melanoma, but mechanisms underlying melanoma development have not been fully elucidated. Here we identified regulator of G protein signaling 4(RGS4) as novel therapeutic target for malignant melanoma and its regulating effect on melanoma. We found that endogenous RGS4 expression was much lower in melanoma tissues and cells. In A375 cell line with low endogenous RGS4 expression, the function of RGS4 was detected by up-regulation its expression with pcDNA3...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069137/use-of-performance-indicators-to-assess-the-solid-waste-management-of-health-services
#13
Mayara C Assis, Vanielle A P Gomes, Wagner C Balista, Rodrigo R DE Freitas
Modern society faces serious challenges, among them, the complexity of environmental problems. Thus, there are several possible sources of environmental degradation, however, the waste produced by health services have an important peculiarity due to its toxic or pathogenic characteristics, since when managed improperly provide also health risk public. The involvement of solid waste from healthcare services environmental impact integrates matters a little more complex, because in addition to environmental health, they also interfere with the healthiness of environments that generate, with the consequences of nosocomial infections, occupational health and public...
2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29023009/myogenic-satellite-cells-biological-milieu-and-possible-clinical-applications
#14
REVIEW
Raed S Said, Ayman G Mustafa, Hasan A Asfour, Emad I Shaqoura
Adult skeletal muscle is a post-mitotic terminally differentiated tissue that possesses an immense potential for regeneration after injury. This regeneration can be achieved by adult stem cells named satellite cells that inhabit the muscular tissue. These cells were first identified in 1961 and were described as being wedged between the plasma membrane of the muscle fiber and the surrounding basement membrane. Since their discovery, many researchers investigated their embryological origin and the exact role they play in muscle regeneration and repair...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28967383/graphene-functionalized-melamine-sponges-for-microextraction-of-sulfonamides-from-food-and-environmental-samples
#15
Theodoros Chatzimitakos, Victoria Samanidou, Constantine D Stalikas
The study describes the functionalization of melamine sponges with graphene and its use as an adsorbent for the microextraction of sulfonamides from food and environmental samples. The graphene-functionalized melamine sponge (GMeS) was prepared by an easy, one-step procedure, which complies with the principles of green chemistry and is proved advantageous over previously described methods. The applicability of the GMeS in extraction procedures was studied and an analytical method for the determination of sulfonamides in milk, eggs and lake water was developed and validated according to SANCO/12571/2013 guideline...
November 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28967296/development-of-expertise-in-elite-and-sub-elite-british-rugby-league-players-a-comparison-of-practice-experiences
#16
COMPARATIVE STUDY
Martyn Rothwell, Joseph A Stone, Keith Davids, Craig Wright
Previous studies have investigated how individuals reach an expert level by counting the number of hours engaged in specific practice types. Here we sought to understand and compare the microstructure (e.g. practice tasks undertaken) of these practice hours experienced by elite and sub-elite British rugby league players. Semi-structured interviews explored the practice experiences of eight international and eight domestic level players. A two-staged thematic analysis was used to interpret the data. The analysis revealed that both player groups experienced a rich and narrow landscape of affordances and were exposed to early diversification of sports experiences during childhood...
November 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28961163/object-classification-in-semi-structured-enviroment-using-forward-looking-sonar
#17
Matheus Dos Santos, Pedro Otávio Ribeiro, Pedro Núñez, Paulo Drews, Silvia Botelho
The submarine exploration using robots has been increasing in recent years. The automation of tasks such as monitoring, inspection, and underwater maintenance requires the understanding of the robot's environment. The object recognition in the scene is becoming a critical issue for these systems. On this work, an underwater object classification pipeline applied in acoustic images acquired by Forward-Looking Sonar (FLS) are studied. The object segmentation combines thresholding, connected pixels searching and peak of intensity analyzing techniques...
September 29, 2017: Sensors
https://www.readbyqxmd.com/read/28960875/experiences-and-lessons-learned-for-planning-and-supply-of-micronutrient-powders-interventions
#18
Claudia Schauer, Nigel Sunley, Carrie Hubbell Melgarejo, Christina Nyhus Dhillon, Claudia Roca, Gustavo Tapia, Pragya Mathema, Shelley Walton, Ruth Situma, Stanley Zlotkin, Rolf Dw Klemm
Realistic planning for a nutrition intervention is a critical component of implementation, yet effective approaches have been poorly documented. Under the auspices of "The Micronutrient Powders Consultation: Lessons Learned for Operational Guidance," 3 working groups were formed to summarize experiences and lessons across countries regarding micronutrient powders (MNP) interventions for young children. This paper focuses on programmatic experiences in the planning stages of an MNP intervention, encompassing assessment, enabling environment and adaptation, as well as considerations for supply...
September 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28944269/sports-and-environmental-temperature-from-warming-up-to-heating-up
#19
REVIEW
Sébastien Racinais, Scott Cocking, Julien D Périard
Most professional and recreational athletes perform pre-conditioning exercises, often collectively termed a 'warm-up' to prepare for a competitive task. The main objective of warming-up is to induce both temperature and non-temperature related responses to optimize performance. These responses include increasing muscle temperature, initiating metabolic and circulatory adjustments, and preparing psychologically for the upcoming task. However, warming-up in hot and/or humid ambient conditions increases thermal and circulatory strain...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28917808/single-drop-gold-nanoparticles-for-headspace-microextraction-and-colorimetric-assay-of-mercury-ii-in-environmental-waters
#20
Tesfaye Tolessa, Zhi-Qiang Tan, Yong-Guang Yin, Jing-Fu Liu
A novel headspace colorimetric nanosensor strategy for specific detection of Hg(II) was developed based upon analyte induced etching and amalgamation of gold nanoparticles (AuNPs). The Hg(II) was first selectively reduced to its volatile form, Hg(0), by stannous chloride (SnCl2 ) through chemical cold vapor generation (CVG) reaction. Then, the Hg(0) was headspace extracted into 37μL thioglycolic acid functionalized AuNP aqueous suspension containing 10% methanol as extractant and simultaneously reacted with AuNPs through the strong metallophilic Hg-Au interaction, resulting in a red-to-blue color change...
January 1, 2018: Talanta
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