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https://www.readbyqxmd.com/read/30479076/characteristics-of-adult-severe-refractory-asthma-in-korea-analyzed-from-the-severe-asthma-registry
#1
Min Hye Kim, Sang Heon Kim, So Young Park, Ga Young Ban, Joo Hee Kim, Jae Woo Jung, Ji Yong Moon, Woo Jung Song, Hyouk Soo Kwon, Jae Woo Kwon, Jae Hyun Lee, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, Kwang Ha Yoo, Yeon Mok Oh, Young Il Koh, An Soo Jang, Byung Jae Lee, Young Joo Cho, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon, You Sook Cho
PURPOSE: Although mild to moderate asthma is much more common, the morbidity and mortality of severe asthma are much higher. This study was performed to identify and analyze the clinical characteristics of severe asthma in Korea. METHODS: We registered patients with severe refractory asthma into the Severe Asthma Registry supported by the Severe Asthma Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology. Patients were enrolled since 2010 from the 15 university hospitals nationwide in Korea...
January 2019: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/30472801/perinatal-probiotic-intervention-prevented-allergic-disease-in-a-caesarean-delivered-subgroup-at-13-year-follow-up
#2
S Kallio, A K Kukkonen, E Savilahti, M Kuitunen
BACKGROUND: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial. OBJECTIVE: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. METHODS: Pregnant women (n=1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomised to receive a mixture of probiotics (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double-blind manner from 36 weeks of gestation until birth...
November 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30471203/assessment-of-lateral-mitral-septal-and-tricuspid-myocardial-performance-indices-by-tissue-doppler-imaging-in-asthmatic-children
#3
Magda Yehia Elseify, Asmaa Alhusseiny Alsharkawy, Marwa Moustapha Al-Fahham, Mahmoud Muhamed ElHady
INTRODUCTION: Recurrent hypoxia makes asthmatics at risk for pulmonary hypertension and ventricular dysfunction. Early stages of these cardiovascular diseases cannot be detected by conventional echocardiography. Tissue Doppler imaging has been introduced recently as a more sensitive & more accurate tool for investigating cardiovascular diseases. OBJECTIVE: investigating ventricular functions in asymptomatic asthmatic children using tissue Doppler echocardiography...
November 24, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/30468508/recent-advances-in-the-management-of-allergy-associated-diseases-in-children
#4
L Zhu, F Zhu, Z-K Zhang
The allergy symptoms could arise from variable organ systems and have fluctuating nature in severity as well as symptoms. Moreover, these symptoms could be related to multiple pathological states like common cold, chronic obstipation, diarrhea, etc. On the other hand, food allergy diagnosis that usually spread by IgE-mediated inhalant also poses a great challenge in front of the scientific fraternity. So far, many advances in the field of allergy diagnosis, as well as therapeutics, have been made. These advances include skin prick testing (SPT), serum specific IgE (sIgE) level test, component resolved diagnosis (CRD) test, etc...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30448840/evaluation-of-the-potential-risk-factors-for-drug-induced-anaphylaxis-in-adult-patients
#5
Semra Demir, Fusun Erdenen, Asli Gelincik, Derya Unal, Muge Olgac, Raif Coskun, Bahauddin Colakoglu, Suna Buyukozturk
AIM: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonanaphylaxis group. The anaphylaxis group was diagnosed according to the criteria of the World Allergy Organization. Skin testing with culprit drugs was performed...
November 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30423826/cellular-and-molecular-events-in-the-airway-epithelium-defining-the-interaction-between-house-dust-mite-group-1-allergens-and-innate-defences
#6
REVIEW
Jihui Zhang, Jie Chen, Clive Robinson
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. By increasing the detection of any allergen by dendritic antigen presenting cells, upregulating inflammatory signalling molecules, and activating cells crucial to the transition from innate to acquired immune responses, the proteolytic activity of these HDM allergens also underlies their behaviour as inhalant allergens. The significance of this property is underlined by the attenuation of allergic responses to HDMs by novel inhibitors in experimental models...
November 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30410551/first-reported-pediatric-cases-of-american-ginseng-anaphylaxis-and-allergy
#7
Stephanie C Erdle, Edmond S Chan, Hyungjun Yang, Bruce A Vallance, Christopher Mill, Tiffany Wong
Background: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30407207/strategies-to-reduce-corticosteroid-related-adverse-events-in-asthma
#8
Enrico Heffler, Diego Bagnasco, Giorgio Walter Canonica
PURPOSE OF REVIEW: Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patients are also often affected by rhinitis or chronic rhinosinusitis requiring frequent use of intranasal corticosteroids. Therefore, severe asthmatics are exposed to an overload of corticosteroids that is frequently associated with relevant and costly adverse events. This clinical problem and the strategies to overcome it are here summarized...
November 6, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30372537/recent-developments-and-highlights-in-allergen-immunotherapy
#9
O Pfaar, H Lou, Y Zhang, L Klimek, L Zhang
Allergen immunotherapy (AIT) is the only disease-modifying treatment option for patients with IgE-mediated inhalant allergies. Though used in clinical practice for more than 100 years, most innovations in AIT efficacy and safety have been developed in the last two decades. This expert review aimed to highlight the recent progress in AIT for both application routes, the sublingual (SLIT) and subcutaneous (SCIT) forms. As such, it covers recent aspects regarding efficacy and safety in clinical trials and real-life data and outlines new concepts in consensus and position papers as well as in guidelines for AIT...
October 29, 2018: Allergy
https://www.readbyqxmd.com/read/30360658/swept-source-optical-coherence-tomography-analysis-in-asthmatic-children-under-inhaled-corticosteroid-therapy
#10
Murat Gunay, Mahmut Dogru, Gokhan Celik, Betul Onal Gunay
PURPOSE: To evaluate retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), subfoveal choroidal thickness (SFCT) and central retinal thickness (CRT) in asthmatic children who were under inhaled corticosteroid treatment by using Swept-Source Optical Coherence Tomography (SS-OCT). MATERIALS AND METHODS: Fifty-three children were prospectively analysed in the study. Group 1 included 31 asthmatic children and group 2 included 22 healthy children...
October 26, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/30297084/visualizing-immune-responses-of-the-airway-mucosa
#11
Tibor Z Veres
The airway mucosa is the primary tissue site exposed to inhaled particulate matter, which includes pathogens and allergens. While most inhaled particles are eliminated from the airways via mucociliary clearance, some pathogens may penetrate the mucosal epithelial barrier and an effective activation of the mucosal immune system is required to prevent further pathogen spread. Similarly, inhaled environmental allergens may induce an aberrant activation of immune cells in the airway mucosa, causing allergic airway disease...
October 3, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/30275843/asthma
#12
REVIEW
Jaclyn Quirt, Kyla J Hildebrand, Jorge Mazza, Francisco Noya, Harold Kim
Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICS) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2 -agonist inhalers are preferred for most adults who fail to achieve control with ICS therapy...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30273429/positivity-rates-of-in-vitro-inhalant-respiratory-and-food-allergy-tests-in-the-northern-midwestern-united-states
#13
Michael S Benninger, Thomas Daly, Kevin Graffmiller
Rates of allergy-test positivity vary by country and by regions within countries. Several studies have looked at allergy test results to determine the most common allergens. Many of these studies have been based on surveys or on studies of small numbers of tests. Positivity rates for allergy tests are poorly defined in the northern midwestern region of the United States. We conducted a study to identify the rates of positive allergy tests for both inhalant/respiratory allergens and food allergens in the upper Midwest...
September 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/30271964/vesicle-associated-membrane-protein-7-mediated-eosinophil-degranulation-promotes-allergic-airway-inflammation-in-mice
#14
Lian Willetts, Lindsey C Felix, Elizabeth A Jacobsen, Lakshmi Puttagunta, Rachel M Condjella, Katie R Zellner, Sergei I Ochkur, John D Kim, Huijun Luo, Nancy A Lee, James J Lee, Redwan Moqbel, Paige Lacy
Eosinophil degranulation is a determining factor in allergy-mediated airway pathology. Receptor-mediated degranulation in eosinophils requires vesicle-associated membrane protein 7 (VAMP-7), a principal component of the SNARE fusion machinery. The specific contribution of eosinophil degranulation to allergen-induced airway responses remains poorly understood. We generated mice with VAMP-7 gene deficiency exclusively in eosinophils ( eoCRE/V7 ) from a cross using eosinophil-specific Cre recombinase-expressing mice crossed with VAMP-7 f/f mice...
2018: Communications biology
https://www.readbyqxmd.com/read/30245286/molecular-diagnostics-improves-diagnosis-and-treatment-of-respiratory-allergy-and-food-allergy-with-economic-optimization-and-cost-saving
#15
S Peveri, S Pattini, M T Costantino, C Incorvaia, M Montagni, C Roncallo, D Villalta, E Savi
BACKGROUND: Component resolved diagnosis (CRD) allows to precisely identify the sensitization to specific molecules of a given allergenic source, resulting in an important improvement in clinical management, particularly of polysensitized subjects. This will end in the correct prescription of allergen immunotherapy (AIT) for respiratory allergy and in adequate avoidance diets or prescription of self-injectable adrenaline in food allergy. OBJECTIVE: The aim of this multicenter, real life study is to evaluate the percentage change of the diagnostic-therapeutic choice in polysensitized patients with respiratory allergy and in patients with food allergy, after using CRD compared to a first level diagnosis, along with an economic analysis of the patient's overall management according to the two different approaches...
September 20, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/30228058/allergic-reactions-in-oral-and-perioral-diseases-what-do-allergy-skin-test-results-show
#16
J Budimir, M Mravak-Stipetić, V Bulat, I Ferček, I Japundžić, L Lugović-Mihić
OBJECTIVE: The aim of this study was to examine potential allergic reactions to different materials in oral and perioral diseases. STUDY DESIGN: The study included 230 consenting subjects in total-180 patients with oral and perioral diseases (30 patients each in the following groups: angioedema, oral lichenoid reactions [OLRs], burning mouth syndrome [BMS], gingivostomatitis, cheilitis, and perioral dermatitis) and 50 healthy controls. Comprehensive diagnostic workups were performed prior to patch testing with standard series allergens and with specific dental materials and skin prick testing (SPT) for food, preservatives and additives, and inhalants...
August 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30215951/allergy-testing-common-questions-and-answers
#17
Ku-Lang Chang, Juan Carlos Guarderas
An estimated 10% to 30% of the global population has an allergic disease. Clinical presentations of allergic diseases, respiratory infections, and autoimmune conditions have similar features. Allergy and immunologic testing can help clarify the diagnosis and guide treatment. Immediate immunoglobulin E (IgE) and delayed T cell-mediated reactions are the main types of allergic responses. The allergens suspected in an immediate IgE-mediated response are identified through serum IgE-specific antibody or skin testing...
July 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30194887/improved-lung-function-at-age-6-in-children-born-very-preterm-and-fed-extra-protein-post-discharge
#18
Line Hedegaard Toftlund, Lone Agertoft, Susanne Halken, Gitte Zachariassen
BACKGROUND: In very preterm-born children alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm. METHODS: This study is a six years follow-up of 281 very preterm-born infants (VPI) with a gestational age (GA) < 32+0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF)...
September 8, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30190445/fungal-sinusitis-among-patients-with-chronic-rhinosinusitis-who-underwent-endoscopic-sinus-surgery
#19
Joanna Leszczyńska, Grażyna Stryjewska-Makuch, Grażyna Lisowska, Bogdan Kolebacz, Marta Michalak-Kolarz
INTRODUCTION: Fungal paranasal sinusitis can be either invasive or non-invasive. Saprophytic infections, fungus balls (FB) and allergic fungal rhinosinusitis are non-invasive (AFR). MATERIALS AND METHODS: The present study examined 521 patients who underwent endoscopic sinus surgery between January 2016 and April 2017 due to chronic paranasal sinusitis at the Department of Laryngology and Laryngological Oncology of the Upper Silesian Medical Centre in Katowice. The aim of the study was to analyse the histopathological and microbiological material collected intraoperatively and to determine the incidence and type of fungal infections among patients treated for chronic sinusitis...
June 20, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/30172018/cross-reactive-aeroallergens-which-need-to-cross-our-mind-in-food-allergy-diagnosis
#20
Margaretha A Faber, Athina L Van Gasse, Ine I Decuyper, Vito Sabato, Margo M Hagendorens, Christel Mertens, Chris H Bridts, Luc S De Clerck, Didier G Ebo
Secondary food allergies due to cross-reactivity between inhalant and food allergens are a significant and increasing global health issue. Cross-reactive food allergies predominantly involve plant-derived foods resulting from a prior sensitization to cross-reactive components present in pollen (grass, tree, weeds) and natural rubber latex. Also, primary sensitization to allergens present in fungi, insects, and both nonmammalian and mammalian meat might induce cross-reactive food allergic syndromes. Correct diagnosis of these associated food allergies is not always straightforward and can pose a difficult challenge...
November 2018: Journal of Allergy and Clinical Immunology in Practice
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