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Inhalant allergy

Tibor Z Veres
The airway mucosa is the primary tissue site exposed to inhaled particulate matter, which includes pathogens and allergens. While most inhaled particles are eliminated from the airways via mucociliary clearance, some pathogens may penetrate the mucosal epithelial barrier and an effective activation of the mucosal immune system is required to prevent further pathogen spread. Similarly, inhaled environmental allergens may induce an aberrant activation of immune cells in the airway mucosa, causing allergic airway disease...
October 3, 2018: Cellular Immunology
Jaclyn Quirt, Kyla J Hildebrand, Jorge Mazza, Francisco Noya, Harold Kim
Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICS) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2 -agonist inhalers are preferred for most adults who fail to achieve control with ICS therapy...
2018: Allergy, Asthma, and Clinical Immunology
Michael S Benninger, Thomas Daly, Kevin Graffmiller
Rates of allergy-test positivity vary by country and by regions within countries. Several studies have looked at allergy test results to determine the most common allergens. Many of these studies have been based on surveys or on studies of small numbers of tests. Positivity rates for allergy tests are poorly defined in the northern midwestern region of the United States. We conducted a study to identify the rates of positive allergy tests for both inhalant/respiratory allergens and food allergens in the upper Midwest...
September 2018: Ear, Nose, & Throat Journal
Lian Willetts, Lindsey C Felix, Elizabeth A Jacobsen, Lakshmi Puttagunta, Rachel M Condjella, Katie R Zellner, Sergei I Ochkur, John D Kim, Huijun Luo, Nancy A Lee, James J Lee, Redwan Moqbel, Paige Lacy
Eosinophil degranulation is a determining factor in allergy-mediated airway pathology. Receptor-mediated degranulation in eosinophils requires vesicle-associated membrane protein 7 (VAMP-7), a principal component of the SNARE fusion machinery. The specific contribution of eosinophil degranulation to allergen-induced airway responses remains poorly understood. We generated mice with VAMP-7 gene deficiency exclusively in eosinophils ( eoCRE/V7 ) from a cross using eosinophil-specific Cre recombinase-expressing mice crossed with VAMP-7 f/f mice...
2018: Communications biology
S Peveri, S Pattini, M T Costantino, C Incorvaia, M Montagni, C Roncallo, D Villalta, E Savi
BACKGROUND: Component resolved diagnosis (CRD) allows to precisely identify the sensitization to specific molecules of a given allergenic source, resulting in an important improvement in clinical management, particularly of polysensitized subjects. This will end in the correct prescription of allergen immunotherapy (AIT) for respiratory allergy and in adequate avoidance diets or prescription of self-injectable adrenaline in food allergy. OBJECTIVE: The aim of this multicenter, real life study is to evaluate the percentage change of the diagnostic-therapeutic choice in polysensitized patients with respiratory allergy and in patients with food allergy, after using CRD compared to a first level diagnosis, along with an economic analysis of the patient's overall management according to the two different approaches...
September 20, 2018: Allergologia et Immunopathologia
J Budimir, M Mravak-Stipetić, V Bulat, I Ferček, I Japundžić, L Lugović-Mihić
OBJECTIVE: The aim of this study was to examine potential allergic reactions to different materials in oral and perioral diseases. STUDY DESIGN: The study included 230 consenting subjects in total-180 patients with oral and perioral diseases (30 patients each in the following groups: angioedema, oral lichenoid reactions [OLRs], burning mouth syndrome [BMS], gingivostomatitis, cheilitis, and perioral dermatitis) and 50 healthy controls. Comprehensive diagnostic workups were performed prior to patch testing with standard series allergens and with specific dental materials and skin prick testing (SPT) for food, preservatives and additives, and inhalants...
August 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Ku-Lang Chang, Juan Carlos Guarderas
An estimated 10% to 30% of the global population has an allergic disease. Clinical presentations of allergic diseases, respiratory infections, and autoimmune conditions have similar features. Allergy and immunologic testing can help clarify the diagnosis and guide treatment. Immediate immunoglobulin E (IgE) and delayed T cell-mediated reactions are the main types of allergic responses. The allergens suspected in an immediate IgE-mediated response are identified through serum IgE-specific antibody or skin testing...
July 1, 2018: American Family Physician
Line Hedegaard Toftlund, Lone Agertoft, Susanne Halken, Gitte Zachariassen
BACKGROUND: In very preterm-born children alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm. METHODS: This study is a six years follow-up of 281 very preterm-born infants (VPI) with a gestational age (GA) < 32+0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF)...
September 8, 2018: Pediatric Allergy and Immunology
Joanna Leszczyńska, Grażyna Stryjewska-Makuch, Grażyna Lisowska, Bogdan Kolebacz, Marta Michalak-Kolarz
INTRODUCTION: Fungal paranasal sinusitis can be either invasive or non-invasive. Saprophytic infections, fungus balls (FB) and allergic fungal rhinosinusitis are non-invasive (AFR). MATERIALS AND METHODS: The present study examined 521 patients who underwent endoscopic sinus surgery between January 2016 and April 2017 due to chronic paranasal sinusitis at the Department of Laryngology and Laryngological Oncology of the Upper Silesian Medical Centre in Katowice. The aim of the study was to analyse the histopathological and microbiological material collected intraoperatively and to determine the incidence and type of fungal infections among patients treated for chronic sinusitis...
June 20, 2018: Otolaryngologia Polska
Margaretha A Faber, Athina L Van Gasse, Ine I Decuyper, Vito Sabato, Margo M Hagendorens, Christel Mertens, Chris H Bridts, Luc S De Clerck, Didier G Ebo
Secondary food allergies due to cross-reactivity between inhalant- and food allergens are a significant and increasing global health issue. Cross-reactive food allergies predominantly involve plant-derived foods resulting from a prior sensitization to cross-reactive components present in pollen (grass, tree, weeds) and natural rubber latex (NRL). But also primary sensitisation to allergens present in fungi, insects and both non-mammalian and mammalian meat might induce cross-reactive food allergic syndromes...
August 29, 2018: Journal of Allergy and Clinical Immunology in Practice
Nathan Falk
Asthma is a heterogeneous condition involving various levels of chronic airway inflammation, bronchoconstriction, airway hyperresponsiveness, and mucus production. Although inhaled corticosteroids and long-acting bronchodilators have improved patient outcomes, asthma remains uncontrolled for at least 10% of patients, even when use of these therapies is maximized. Improved understanding of the biology, genetics, and role of immune cell signaling in asthma has led to the development of immunobiologic therapies...
September 2018: FP Essentials
Sofie Ravall, Susanna Simberg
OBJECTIVES: Singers have reported higher prevalence of vocally harmful behaviors, vocal symptoms, and voice disorders than nonsingers have. The purpose of this study was to investigate the prevalence of voice disorders among choir singers and to discover the risk factors associated with voice disorders. Another purpose was to explore the choir singers' knowledge about the anatomy and physiology of the voice, and voice ergonomics. METHODS: Three hundred and fifteen adult choir singers, 65% women, and 35% men, completed a web-questionnaire...
August 10, 2018: Journal of Voice: Official Journal of the Voice Foundation
Jung-Hyun Kim, Sae-Hoon Kim, Heung-Woo Park, Sang-Heon Cho, Yoon-Seok Chang
Background: Oral allergy syndrome (OAS) is a type of allergic reaction that mainly occurs on oral contact with raw fruit, vegetables, or nuts. The most common type of OAS is birch pollen-related food allergy. Although OAS is a common food allergy in adults, only few epidemiologic studies have been reported in Korea. Here we investigate the prevalence and triggers of birch pollen-related food allergy. Methods: We conducted a retrospective chart review of 1,427 patients who underwent a skin prick test for inhalant allergens at the Asthma and Allergy Clinic in Seoul National University Bundang Hospital from January 2011 to December 2016...
August 13, 2018: Journal of Korean Medical Science
Cecilia Gretchen Navarro-Locsin, Margaret Lim-Jurado
Background: There is a large global variation in sensitization patterns to aeroallergens due to differences in climate, urbanization, and lifestyle. Knowledge of the most common inhalant allergens is important for appropriate prevention and management of allergic rhinitis (AR). Objective: This study aims to provide data on aeroallergen sensitization patterns and associated comorbid diseases of adult Filipinos with AR. Methods: Medical records of adult Filipinos seen in an Otolaryngology-Allergy Clinic from January 2011 to 2016 were reviewed...
July 2018: Asia Pacific Allergy
Jarmila Čelakovská, Josef Bukač, Karel Ettler, Jaroslava Vaneckova, Kvetuse Ettlerova
Background: In adult patients suffering from atopic dermatitis (AD), studies investigating the co-prevalence of AD and food allergy are still scarce, and exact data are not available. Aims and Objectives: To evaluate the occurrence of food allergy to peanuts in significant relation to food hypersensitivity, inhalant allergy and to asthma bronchial and rhinitis. Materials and Methods: Altogether 332 patients of AD 14 year or older were included in the study...
July 2018: Indian Journal of Dermatology
Hevertton Luiz Bozzo Silva Santos, Silvia de Souza E Silva, Estela de Paula, Lilian Pereira-Ferrari, Liya Mikami, Carlos Antônio Riedi, Herberto José Chong-Neto, Nelson Augusto Rosário
OBJECTIVE: To verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics. METHODS: A cross sectional study of 77 children aged 7 to 14 years old, who were attended at a specialized clinic. The children were divided into 3 groups: asthmatics who had been using inhaled corticosteroids (ICS) for more than one year; asthmatics who had not been using ICS; non-asthmatics, and children without allergies (according to the International Study of Asthma and Allergies in Childhood -- ISAAC)...
July 26, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Shaista Khan, Muhammad Hassan Khaskheli, Ghulam Nabi, Bikha Ram Deverajani, Naima Memon, Ghulam Abbas Shar
Wheat allergy specifically refers to the adverse reaction involving IgE antibody to one or more protein fraction of wheat such as albumin, globulin, gliadin and glutenin (gluten). The majority of IgE-mediated reactions to wheat involve albumin and globulin fraction while gluten (gliadin & glutenin) also cause allergy (Celiac disease). Allergic reactions to wheat may be caused by ingestion of wheat containing foods or inhalation of flour (Bakers asthma). The present study was an effort to explore the antibody response of different proteins present in wheat...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Vijaya Knight, Molly L Wolf, Anita Trikha, Douglas Curran-Everett, Melissa Hiserote, Ronald J Harbeck
Although skin-prick testing (SPT) is commonly used by allergists in the evaluation of allergy, in-vitro testing for specific IgE (sIgE) is an attractive alternate because it can be performed remotely and is of utility when SPT is contraindicated, as in patients on anti-histamines, or with dermatitis or severe eczema. It is, however, necessary to determine the extent of correlation between the in-vitro and in-vivo methods. In this study, we examined the qualitative concordance between SPT and sIgE as measured on the HYTEC™288 platform for 10 commonly encountered inhalant allergens in 232 subjects, and analysed the performance characteristics for the HYTEC™288...
November 2018: Journal of Immunological Methods
S Hashimoto, L H Rijssenbeek-Nouwens, K B Fieten, E J Weersink, E H Bel
BACKGROUND: High-altitude climate therapy has been shown to benefit patients with severe asthma but it is not known which patients benefit most from this treatment. In the current study we aimed to identify clinical, functional and inflammatory predictors of favourable outcome of high-altitude climate therapy. METHODS: This is a secondary analysis of a prospective cohort including 136 adult patients with a diagnosis of severe refractory asthma, referred to the Dutch Asthma Centre in Davos (1600 metres above sea level), Switzerland...
July 2018: Netherlands Journal of Medicine
Johannes Waage, Marie Standl, John A Curtin, Leon E Jessen, Jonathan Thorsen, Chao Tian, Nathan Schoettler, Carlos Flores, Abdel Abdellaoui, Tarunveer S Ahluwalia, Alexessander C Alves, Andre F S Amaral, Josep M Antó, Andreas Arnold, Amalia Barreto-Luis, Hansjörg Baurecht, Catharina E M van Beijsterveldt, Eugene R Bleecker, Sílvia Bonàs-Guarch, Dorret I Boomsma, Susanne Brix, Supinda Bunyavanich, Esteban G Burchard, Zhanghua Chen, Ivan Curjuric, Adnan Custovic, Herman T den Dekker, Shyamali C Dharmage, Julia Dmitrieva, Liesbeth Duijts, Markus J Ege, W James Gauderman, Michel Georges, Christian Gieger, Frank Gilliland, Raquel Granell, Hongsheng Gui, Torben Hansen, Joachim Heinrich, John Henderson, Natalia Hernandez-Pacheco, Patrick Holt, Medea Imboden, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Deborah L Jarvis, Kamilla K Jensen, Ingileif Jónsdóttir, Michael Kabesch, Jaakko Kaprio, Ashish Kumar, Young-Ae Lee, Albert M Levin, Xingnan Li, Fabian Lorenzo-Diaz, Erik Melén, Josep M Mercader, Deborah A Meyers, Rachel Myers, Dan L Nicolae, Ellen A Nohr, Teemu Palviainen, Lavinia Paternoster, Craig E Pennell, Göran Pershagen, Maria Pino-Yanes, Nicole M Probst-Hensch, Franz Rüschendorf, Angela Simpson, Kari Stefansson, Jordi Sunyer, Gardar Sveinbjornsson, Elisabeth Thiering, Philip J Thompson, Maties Torrent, David Torrents, Joyce Y Tung, Carol A Wang, Stephan Weidinger, Scott Weiss, Gonneke Willemsen, L Keoki Williams, Carole Ober, David A Hinds, Manuel A Ferreira, Hans Bisgaard, David P Strachan, Klaus Bønnelykke
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2 . To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls...
August 2018: Nature Genetics
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