keyword
https://read.qxmd.com/read/38403583/an-ethnobotanical-study-of-wild-edible-fruits-in-miombo-woodlands-of-tabora-region-in-western-tanzania
#21
JOURNAL ARTICLE
Michael Elias Mgalula
BACKGROUND: Wild edible fruits found in Tanzania's miombo woods are an indispensable source of food and medicine. Unfortunately, with the rapid expansion of human activities and urbanisation in the Tabora rural, Uyui and Sikonge districts of Western Tanzania, some wild fruits are disappearing due to the loss of plant diversity. The objectives of this study wereL: to document the knowledge related to wild edible fruits; to quantify the use and cultural significance, and to determine their threats...
February 25, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38401110/exploration-of-holistic-nursing-strategy-for-diabetic-patients-with-pulmonary-tuberculosis
#22
JOURNAL ARTICLE
Yamin Zhao, Wei Yuan, Fang Zhao, Jie Yang
OBJECTIVE: To explore the application effect of comprehensive nursing based on medical-care integration in diabetic patients with pulmonary tuberculosis. METHODS: 80 diabetic patients with pulmonary tuberculosis who were treated at Affiliated Hospital of Hebei University from March 2022 to March 2023 were randomly divided into the routine nursing group and the comprehensive nursing group. The routine nursing group received conventional nursing care, while the comprehensive nursing group received comprehensive nursing based on medical-care integration and routine care...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38397496/in-vitro-hypoglycemic-activities-of-lactobacilli-and-bifidobacterium-strains-from-healthy-children-s-sources-and-their-effect-on-stimulating-glp-1-secretion-in-stc-1-cells
#23
JOURNAL ARTICLE
Zhiliang Cheng, Jingru Chen, Yulong Zhang, Xinyi Li, Ning Zhang, Fei Liu, Yuehua Jiao
A long-term use of chemical drugs cannot cure type II diabetes mellitus (T2DM) and their numerous toxic side effects can be harmful to human health. In recent years, probiotics have emerged as a natural resource to replace chemical drugs in alleviating many human ailments. Healthy children's intestines have a lot of colonized Lactobacilli and Bifidobacterium , and these beneficial bacteria can help promote overall health. The objective of this study was to isolate potential antidiabetic probiotic strains from healthy children and evaluate their application prospects...
February 7, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38389974/test-of-insulin-resistance-in-nondiabetic-and-streptozotocin-induced-diabetic-rats-using-glycosylated-hemoglobin-test-and-other-interventions
#24
JOURNAL ARTICLE
Lina AlTamimi, Zainab Z Zakaraya, Mohammad Hailat, Mousa N Ahmad, Nidal A Qinna, Mohammed F Hamad, Wael Abu Dayyih
Type 2 diabetes is common globally. Pioglitazone (PGZ) is an oral TZD antidiabetic, whereas chromium-picolinate (Cr-PL) and Cr-glucose tolerance factor (Cr-GTF) are useful type 2 diabetes mellitus (T2DM) supplements. Cr-PL/GTF antioxidants cure T2DM. They may fail in diabetes with or without insulin-sensitizing medications. It examined how Cr-PL, Cr-GTF, PGZ, and their combination affected glucose, glycosylated hemoglobin, insulin, and HOMA-IR. Sixty-three adult Sprague-Dawley rats (220-300 g) were selected, and nine rats were randomly assigned to a normal nondiabetic group...
2024: Journal of Advanced Pharmaceutical Technology & Research
https://read.qxmd.com/read/38383825/bardet-biedl-syndrome-a-clinical-overview-focusing-on-diagnosis-outcomes-and-best-practice-management
#25
JOURNAL ARTICLE
Ashley Shoemaker
Bardet-Biedl syndrome (BBS) is a genetic disorder characterized by early-onset obesity, polydactyly, genital and kidney anomalies, developmental delay and vision loss due to rod-cone dystrophy. BBS is an autosomal recessive disorder with >20 implicated genes. The genotype-phenotype relationship in BBS is not clear, and there may be additional modifying factors. The underlying mechanism is dysfunction of primary cilia. In BBS, receptor trafficking in and out of the cilia is compromised, affecting multiple organ systems...
February 21, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38375094/advances-in-research-related-to-microrna-for-diabetic-retinopathy
#26
REVIEW
Yahan Luo, Chunxia Li
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38371502/fenugreek-derived-diosgenin-as-an-emerging-source-for-diabetic-therapy
#27
REVIEW
Yamini Tak, Manpreet Kaur, Abhishek Chitranashi, Mahesh Kumar Samota, Preeti Verma, Manoj Bali, Chiranjeev Kumawat
Diabetes is a chronic metabolic disease that endangers the entire body's tissues and organs. Diabetes impairs glucose and insulin regulation in the human body by causing pancreatic cell damage. Diabetes modifies pathways such as serine/threonine protein kinase (Akt) and Protein kinase C (PKC)/- glucose transporter 4 (GLUT4), peroxisome proliferator-activated receptor (PPAR) glucose absorption, and inhibits α-amylase and α-glucosidase, Sodium/glucose cotransporter 1 (SGLT-1), and Na+ -K+ -ATPase activity...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38329920/intraperitoneal-vancomycin-plus-levofloxacin-for-the-treatment-of-peritoneal-dialysis-related-peritonitis-in-patients-with-no-response-to-cefazolin-plus-ceftazidime
#28
JOURNAL ARTICLE
Jiafan Zhou, Yajuan Huang, Xing Zhang, Liping Xiong, Rui Zhang, Hongrui Shi
INTRODUCTION: Peritoneal dialysis-related peritonitis (PDRP) should be treated as soon as possible by an empirical regimen without waiting for effluent bacterial culture results. We retrospectively investigated patients treated with vancomycin plus levofloxacin as a treatment regimen if there was no response to cefazolin plus ceftazidime. MATERIALS AND METHODS: We collected records of adult patients with PDRP from January 1, 2013, to November 30, 2020. The characteristics of episodes of PDRP with no response to cefazolin plus ceftazidime treated by intraperitoneal (IP) injection of vancomycin plus levofloxacin were analyzed...
February 8, 2024: Clinical Nephrology
https://read.qxmd.com/read/38318896/-application-of-double-layer-soft-tissue-suture-closure-technique-in-the-surgical-treatment-of-patients-with-mandible-medication-related-osteonecrosis-of-the-jaw-of-early-and-medium-stages
#29
JOURNAL ARTICLE
Ying Zhou, Ning Zhao, Hongyuan Huang, Qingxiang Li, Chuanbin Guo, Yuxing Guo
OBJECTIVE: To investigate the clinical application effect of double-layer soft tissue (DLST) suture closure technique in patients with mandible medication-related osteonecrosis of the jaw (MRONJ) of early and medium stages resulted in application of anti-bone-resorptive drugs. METHODS: Early to medium stage mandible MRONJ patients who underwent surgical treatment in the fourth ward of Peking University School and Hospital of Stomatology from October 2021 to September 2022 were included...
February 18, 2024: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/38318799/on-chip-sorting-of-stem-cell-derived-%C3%AE-cell-clusters-using-traveling-surface-acoustic-waves
#30
JOURNAL ARTICLE
Nikhil Sethia, Joseph Sushil Rao, Zenith Khashim, Anna Marie R Schornack, Michael L Etheridge, Quinn P Peterson, Erik B Finger, John C Bischof, Cari S Dutcher
There is a critical need for sorting complex materials, such as pancreatic islets of Langerhans, exocrine acinar tissues, and embryoid bodies. These materials are cell clusters, which have highly heterogeneous physical properties (such as size, shape, morphology, and deformability). Selecting such materials on the basis of specific properties can improve clinical outcomes and help advance biomedical research. In this work, we focused on sorting one such complex material, human stem cell-derived β cell clusters (SC-β cell clusters), by size...
February 6, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38318626/semi-synthesis-%C3%AE-amylase-inhibition-and-kinetic-and-molecular-docking-studies-of-arylidene-based-sesquiterpene-coumarins-isolated-from-ferula-tunetana-pomel-ex-batt
#31
JOURNAL ARTICLE
Wiem Baccari, Ilyes Saidi, Insaf Filali, Mansour Znati, Houda Lazrag, Moncef Tounsi, Axel Marchal, Pierre Waffo-Teguo, Hichem Ben Jannet
Despite all the significant progresses made to enhance the efficacy of the existing bank of drugs used to manage and cure type II diabetes mellitus, there is still a need to search and develop novel bioactive compounds with superior efficacy and minimal adverse effects. This study describes the valorization of the natural bioactive sesquiterpene coumarin via the semi-synthesis of new analogs and the study of their α-amylase inhibition activity. The sesquiterpene coumarin named coladonin (1) was quantitatively isolated from the chloroform extract of endemic Ferula tunetana roots...
January 31, 2024: RSC Advances
https://read.qxmd.com/read/38313855/clinical-study-of-different-prediction-models-in-predicting-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus
#32
JOURNAL ARTICLE
Sha-Sha Cai, Teng-Ye Zheng, Kang-Yao Wang, Hui-Ping Zhu
BACKGROUND: Among older adults, type 2 diabetes mellitus (T2DM) is widely recognized as one of the most prevalent diseases. Diabetic nephropathy (DN) is a frequent complication of DM, mainly characterized by renal microvascular damage. Early detection, aggressive prevention, and cure of DN are key to improving prognosis. Establishing a diagnostic and predictive model for DN is crucial in auxiliary diagnosis. AIM: To investigate the factors that impact T2DM complicated with DN and utilize this information to develop a predictive model...
January 15, 2024: World Journal of Diabetes
https://read.qxmd.com/read/38310457/therapeutic-potential-of-crispr-cas-in-hashimoto-s-thyroiditis-a-comprehensive-review
#33
JOURNAL ARTICLE
Apoorva Upreeti, Sayali Mukherjee
Hashimoto's thyroiditis (HT) is a commonly occurring illness of autoimmune endocrine origin. It is usually present in the pediatric age group along with other well-known diseases, such as type 1 insulin-dependent diabetes. The defining feature of this disease is the immune-- mediated attack on the thyroid gland resulting in the destruction of thyroid tissues and cells. Given that HT frequently affects family members, it is well-recognized that individuals are genetically predisposed to this disease. Patients with HT also display a significantly increased risk for several different cancers, justifying the eminent need for the development of therapies for managing and treating HT...
January 2, 2024: Current Gene Therapy
https://read.qxmd.com/read/38308979/treatment-of-recalcitrant-esophagocutaneous-fistula-by-platelet-rich-plasma-fibrin-glue-a-case-study
#34
Alireza Rezapanah, Elaheh Emadi, Daryoush Hamidi Alamdari
INTRODUCTION: Recalcitrant esophagocutaneous fistula is a very uncommon complication after neck surgery. Management of this non-healing fistula has long been a topic of debate. This report provides an approach for treating it. PRESENTATION OF CASE: A 65-year-old woman presented nineteen years after branchial cleft cyst surgery with cyst recurrence associated with swelling. Sonography displayed a collection in the front of the left carotid artery in the suprasternal notch...
February 2, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38303706/ultrasound-targeted-microbubble-technology-facilitates-sahh-gene-delivery-to-treat-diabetic-cardiomyopathy-by-activating-ampk-pathway
#35
JOURNAL ARTICLE
Xiaohui Guo, Kegong Chen, Lin Ji, Shanjie Wang, Xiangmei Ye, Liang Xu, Leiguang Feng
Diabetic cardiomyopathy (DCM) is a cardiovascular complication with no known cure. In this study, we evaluated the combination of ultrasound-targeted microbubble destruction (UTMD) and cationic microbubbles (CMBs) for cardiac S-adenosyl homocysteine hydrolase (SAHH) gene transfection as potential DCM therapy. Models of high glucose/fat (HG/HF)-induced H9C2 cells and streptozotocin-induced DCM rats were established. Ultrasound-mediated SAHH delivery using CMBs was a safe and noninvasive approach for spatially localized drug administration both in vitro and in vivo ...
February 16, 2024: IScience
https://read.qxmd.com/read/38292619/honeymoon-phase-in-type-1-diabetes-mellitus-a-window-of-opportunity-for-diabetes-reversal
#36
REVIEW
Madhukar Mittal, Pradakshna Porchezhian, Nitin Kapoor
The knowledge of the pathogenesis of type 1 diabetes mellitus (T1DM) continues to rapidly evolve. The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status. Not all individuals of T1DM progress in that specific sequence. We hereby present a case of T1DM with a classical third phase (honeymoon phase) and discuss the intricacies of this interesting phase along with a possible future promise of "cure" with the use of immunotherapies. We now know that the course of T1DM may not be in only one direction towards further progression; rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed...
January 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38289942/traditional-utilization-of-bamboo-in-the-central-siwalik-region-nepal
#37
JOURNAL ARTICLE
Bishnu Maya K C, Janardan Lamichhane, Sanjay Nath Khanal, Dhurva Prasad Gauchan
Bamboo are the fastest growing perennial woody grasses that have versatile applications. Most of the local people inhabiting the riverine area of the Siwalik region of Nepal rely on bamboo products for economic benefits and medicinal uses. Our objective was to identify the diversity of bamboo species, their ethnomedicinal practices, and economic and ecological importance. Data were collected by direct observation, key informant interviews, participatory rural appraisal, inventory technique, focus group discussions, and a household survey using semi-structured and structured questionnaires...
2024: PloS One
https://read.qxmd.com/read/38282343/effects-of-berberis-vulgaris-fruit-extract-on-oxidative-stress-status-in-the-kidney-and-liver-of-diabetic-rats
#38
JOURNAL ARTICLE
Marzieh Ahmadi, Mousa-Al-Reza Hadjzadeh, Ziba Rajaei
OBJECTIVES: Oxidative stress has a key role in the diabetes pathogenesis and complications. Berberis vulgaris is known in folk medicine for curing several diseases. The current research aimed to assess the influences of Berberis vulgaris fruit extract against oxidative stress in streptozotocin-induced diabetic rats. METHODS: Streptozotocin (60 mg/kg, ip) was injected to male rats. After diabetes confirmation, animals received the Berberis vulgaris fruit extract daily at amounts of 3...
January 29, 2024: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/38279502/chronic-diseases-origin-and-cell-mechanisms-involved
#39
JOURNAL ARTICLE
David Hernán Martínez-Puente, Carlos Saúl Rodríguez-Roque, Laura Mireya Flores-Zavala, José Juan Pérez-Trujillo, Arnulfo Villanueva-Olivo, Humberto Rodríguez-Rocha, Aracely García-García, Odila Saucedo-Cárdenas, Roberto Montes De Oca-Luna, María de Jesús Loera-Arias
Chronic diseases are a worldwide health problem directly related to society, lifestyle, and the development of unhealthy habits over time. Cardiovascular disease, cancer, chronic respiratory disease, and diabetes are the main causes of death. Environmental factors, such as air pollutants, poor diet, genetic predisposition, or a combination of these, are related to the development of these diseases. These factors activate cell mechanisms, such as DNA damage, oxidative stress, endoplasmic reticulum stress, autophagy, inflammation, and cell death...
December 31, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38275040/traditional-herbal-medications-utilized-in-the-indian-medical-system-for-the-management-of-diabetes-an-updated-review-and-clinical-implications
#40
JOURNAL ARTICLE
Kapil Sachan, Suryakant Verma, Kunal Arora, Ujjwal Bharti, Pranjal Kumar Singh, Smita Singh
Phytomedicine, also called botanical medicine, is the practice of using plants to treat disease. Diabetes, for example, has been treated and prevented with herbal medication for a lot longer than Western medicine. Worldwide, diabetes has become a major health concern. The management of diabetes and hyperglycemia, two of the most common public health threats, is far from ideal. When hyperglycemia persists or is not under control, diabetes-related complications, like blindness, lower limb amputations, renal disease, and cardiovascular disease, play a significant role in the morbidity and mortality of the disease...
January 23, 2024: Current Diabetes Reviews
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