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Diabetes Cure

Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren Huang
Indomethacin (IDMT), a non-selective inhibitor of cycloxygenase-2 (COX-2), plays important roles in anti-inflammation and analgesia and it is commonly used to treat the patients with rheumatic and rheumatoid arthritis. Besides, various literatures reported that IDMT is a synthetic ligand of peroxisome proliferator activated receptor gamma (PPARγ). Rosiglitazone (RSG), an insulin-sensitizer, is also a synthetic ligand and applied clinically to cure the patients with type 2 diabetes mellitus. However, up to date little is known about whether IDMT ameliorates endothelial insulin resistance (IR)...
July 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
George Cătălin Marinescu, Roua-Gabriela Popescu, Gheorghe Stoian, Anca Dinischiotu
Diabetes is a chronic and progressive disease with continuously increasing prevalence, rising financial pressure on the worldwide healthcare systems. Recently, the insulin resistance, hallmark of type 2 diabetes, was cured in mice treated with NAD+ precursor β-nicotinamide mononucleotide (NMN), no toxic effects being reported. However, NMN has a high price tag, more cost effective production methods are needed. This study proposes a biotechnological NMN production method in Escherichia coli. We show that bicistronic expression of recombinant nicotinamide phosphoribosyl transferase (Nampt) and phosphoribosyl pyrophosphate (PRPP) synthetase in the presence of nicotinamide (NAM) and lactose may be a successful strategy for cost effective NMN production...
August 16, 2018: Scientific Reports
Kunal Maniar, Vandana Singh, Amal Moideen, Rajasri Bhattacharyya, Amitava Chakrabarti, Dibyajyoti Banerjee
The management of chronic lung diseases such as cancer, asthma, COPD and pulmonary hypertension remains unsatisfactory till date, and several strategies are being tried to control the same. Metformin, a popular anti-diabetic drug has shown promising effects in pre-clinical studies and has been subject to several trials in patients with debilitating pulmonary diseases. However, the clinical evidence for the use of metformin in these conditions is disappointing. Recent observations suggest that metformin use in diabetic patients is associated with an increase in butyrate-producing bacteria in the gut microbiome...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Huidi Tchero, Pauline Kangambega, Lazarre Noubou, Beatrice Becsangele, Fluieraru Sergiu, Luc Teot
Diabetic foot infection is a common diabetic complication that may end in lower limb amputation if not treated properly. We performed this systematic review to assess the clinical efficacy of different antibiotic regimens, whether systemic or topical, in the treatment of moderate to severe diabetic foot infections. We searched Medline, Web of Science, SCOPUS, Cochrane CENTRAL and ScienceDirect for randomized controlled trials that evaluated the efficacy of antibiotic regimens in moderate to severe diabetic foot infections...
August 12, 2018: Wound Repair and Regeneration
Fiona H McLean, Christine Grant, Amanda C Morris, Graham W Horgan, Alex J Polanski, Kevin Allan, Fiona M Campbell, Rosamund F Langston, Lynda M Williams
Alzheimer's disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer's disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet...
August 10, 2018: Scientific Reports
Anamika Singh Gaur, Selvaraman Nagamani, Karunakar Tanneeru, Dmitry Druzhilovskiy, Anastassia Rudik, Vladimir Poroikov, G Narahari Sastry
Molecular Property Diagnostic Suite - Diabetes Mellitus (MPDSDM ) is a Galaxy-based, open source disease-specific web portal for diabetes. It consists of three modules namely i) data library ii) data processing and iii) data analysis tools. The data library (target library and literature) module provide extensive and curated information about the genes involved in type 1 and type 2 diabetes onset and progression stage (available at The database also contains information on drug targets, biomarkers, therapeutics and associated genes specific to type 1, and type 2 diabetes...
August 6, 2018: Journal of Biomedical Informatics
Lavi Rani, Naveen Kumar Gautam
Diabetic nephropathy is the pathological alterations in kidney and is one of the major causes of kidney failure accounting for ~44% of all cases. In spite of the large mortality rate of diabetic nephropathy, accurate cures are not available for the disease at present. Identification of genetic determinants and understanding their role in the progression of disease will be an imperative step for developing diagnostic tool and therapy for the disease. Drosophila melanogaster is a genetically tractable model organism and is being used for understanding the genetic basis of several human diseases...
August 7, 2018: Current Drug Targets
Pierpaolo Cavallo, Sergio Pagano, Mario De Santis, Enrico Capobianco
BACKGROUND: Comorbidity represents the co-occurrence of pathological conditions in the same individual, and presents with very complex patterns. In most cases, reference data for the study of various types of comorbidities linked to complex diseases are those of hospitalized patients. Such patients may likely require cure due to acute conditions. We consider the emerging role of EHR (Electronic Healthcare Records), and study comorbidity patterns in a general population, focusing on diabetic and non-diabetic patients...
July 27, 2018: Journal of Clinical Medicine
Aliye Uc, M Bridget Zimmerman, Michael Wilschanski, Steven L Werlin, David Troendle, Uzma Shah, Sarah Jane Schwarzenberg, Sue Rhee, John F Pohl, Emily R Perito, Joseph J Palermo, Chee Y Ooi, Quin Liu, Tom K Lin, Veronique D Morinville, Brian A McFerron, Sohail Z Husain, Ryan Himes, Melvin B Heyman, Tanja Gonska, Matthew J Giefer, Cheryl E Gariepy, Steven D Freedman, Douglas S Fishman, Melena D Bellin, Bradley Barth, Maisam Abu-El-Haija, Mark E Lowe
OBJECTIVE: The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). METHODS: We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations...
September 2018: Pancreas
Naihan Chen, Charles J Kroger, Roland M Tisch, Eric M Bachelder, Kristy M Ainslie
Type 1 diabetes (T1D) is a common autoimmune disease with no cure. T1D subjects are dependent on daily exogenous insulin administration, due to the loss of functional insulin-producing β cells. Needed are immunotherapies that prevent and/or treat T1D. One approach of immunotherapy is to administer an autoantigen to selectively tolerize diabetogenic effector T cells without global immunosuppression. To date, however, strategies of antigen-specific immunotherapy are largely ineffective in the clinic. Using an antigen-specific approach, a biodegradable polymeric delivery vehicle, acetalated dextran microparticles (Ace-DEX MPs), is applied and T1D development is prevented through coadministration of the immunosuppressant rapamycin and the diabetogenic peptide P31 (Rapa/P31/MPs), via alterations of both innate and adaptive immunity...
July 26, 2018: Advanced Healthcare Materials
Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei
High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications...
2018: Journal of Diabetes Research
Huashan Gao, Ziwei Song, Qian Zhao, You Wu, Shanshan Tang, Murad Alahdal, Yumeng Shen, Yun Xing, Yi Pan, Jing Li, Yanfeng Zhang, Liang Jin
BACKGROUND/AIMS: Abnormal glucose metabolism and lipid metabolism are two key issues in Type 1 diabetes mellitus (T1DM). Insulin can control carbohydrate metabolism adequately, but cannot regulate lipid metabolism well in patients with T1DM. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have cured type 2 diabetes mellitus in clinical trials and have improved T1DM glycemic control in preclinical studies. However, previous studies have not reported whether GLP-1 can lower the serum concentration of non-esterified fatty acids (NEFAs)...
July 24, 2018: Cellular Physiology and Biochemistry
Nazima Batool, Noshin Ilyas, Sumera Shabir, Maimoona Saeed, Roomina Mazhar
Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical systems form 4000 years. Components of M. indica are recurrently used as a traditional medicine system to cure numerous ailments. Active constituents are present in stem bark, leaves, heartwood, roots and fruit and have antioxidant, anti-inflammatory, radioprotective, antitumor, immune-modulatory, anti-allergic, anti-diabetic, anti-bone resorption, mono-amine oxidase inhibiting, anti-viral, anti-fungal, anti-bacterial, anti-spasmodic, antidiarrheal, anti-malarial, antiparasitic as well as lipolytic properties...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Zohra Dhouafli, Karina Cuanalo-Contreras, El Akrem Hayouni, Charles E Mays, Claudio Soto, Ines Moreno-Gonzalez
Protein misfolding and aggregation into fibrillar deposits is a common feature of a large group of degenerative diseases affecting the central nervous system or peripheral organs, termed protein misfolding disorders (PMDs). Despite their established toxic nature, clinical trials aiming to reduce misfolded aggregates have been unsuccessful in treating or curing PMDs. An interesting possibility for disease intervention is the regular intake of natural food or herbal extracts, which contain active molecules that inhibit aggregation or induce the disassembly of misfolded aggregates...
July 20, 2018: Cellular and Molecular Life Sciences: CMLS
Valerio Carelli, Chiara La Morgia
The landmark year 1988 can be considered as the birthdate of mitochondrial medicine, when the first pathogenic mutations affecting mtDNA were associated with human diseases. Three decades later, the field still expands and we are not 'scraping the bottom of the barrel' yet. Despite the tremendous progress in terms of molecular characterization and genotype/phenotype correlations, for the vast majority of cases we still lack a deep understanding of the pathogenesis, good models to study, and effective therapeutic options...
July 20, 2018: Essays in Biochemistry
Kosh Agarwal, Sarah E Brown
Introduction of curative direct-acting antiviral (DAA) agents has transformed the treatment for HCV both pre- and post-liver transplantation (LT).12 Post-LT cure rates with DAAs are now >95%. However, LT recipients are burdened with renal and metabolic comorbidities, and little is known about the benefits of HCV cure on extrahepatic complications of HCV, particularly diabetes mellitus (DM) and renal impairment after LT. This article is protected by copyright. All rights reserved.
July 20, 2018: Liver Transplantation
Waseem Majeed, Hood Thabit
Type 1 diabetes is characterised by destruction of pancreatic beta cells, leading to insulin deficiency and hyperglycaemia. The mainstay of treatment remains lifelong insulin therapy as a sustainable cure has as yet proven elusive. The burden of daily management of type 1 diabetes has contributed to suboptimal outcomes for people living with the condition. Innovative technological approaches have been shown to improve glycaemic and patient-related outcomes. Areas covered: We discuss recent advances in technologies in type 1 diabetes including closed-loop systems, also known as the 'artificial pancreas...
July 30, 2018: Expert Review of Medical Devices
Jessicca D Abron, Narendra P Singh, Robert L Price, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh
Mucosal changes in Crohn's disease (CD) and ulcerative colitis (UC), two major forms of inflammatory bowel disease (IBD), are characterized by a prominent infiltration of inflammatory cells including lymphocytes, macrophages, T cells and neutrophils. The precise etiology of IBD is unknown but it involves a complex interplay of factors associated with the immune system, environment, host genotype and enteric commensal bacteria. As there is no known safe cure for IBD, natural alternative therapeutic options without side effects are urgently needed...
2018: PloS One
Jack Williams, Nicholas Jacus, Kevin Kavalackal, Kirstie K Danielson, Rebecca S Monson, Yong Wang, Jose Oberholzer
Islet cell transplantation is a promising functional cure for type 1 diabetes; however, maintaining long-term islet graft function and insulin independence is difficult to achieve. In this short report we present a patient with situs inversus, who at the time of islet transplantation had a 26-year history of type 1 diabetes, complicated by hypoglycemic unawareness and severe hypoglycemic events. After a single allogeneic islet transplant of a low islet mass, and despite developing de novo anti-insulin and anti-GAD65 autoantibodies, the patient has remarkably maintained insulin independence with tight glycemic control and normal metabolic profiles for 10 years, after receiving prolonged non-T-cell depleting immunosuppression...
July 19, 2018: Islets
Liping Zhang, Lingyu Zhang, Lin Li, Christian Hölscher
Parkinson's disease (PD) is the second most common neurodegenerative disease, and there is no recognised therapy to cure it. Recently, it has been shown that treatments to improve insulin resistance in type 2 diabetes (T2DM) may be useful for PD patients. In previous studies, the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide showed good neuroprotective effects in animal models of PD. In addition, the GLP-1 mimetic exendin-4 has shown good protective effects in PD patients in a phase II clinical trial...
July 11, 2018: Neuropeptides
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