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Diabetes Cure

M Ahmed, S Lutze, M Tembulatow, G Daeschlein, M Jünger, A Arnold
BACKGROUND: Chronic venous disease (CVD) is extremely common worldwide. The prevalence is increasing with age and is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its' endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. To our knowledge up to now no coherent study has been undertaken in patients with CVI who underwent an open venous surgery concerning complications, venous hemodynamics and perioperative symptomology in one study population...
October 11, 2018: Journal of Neuromuscular Diseases
Ramamoorthy Jayashri, Ulagamathesan Venkatesan, Menon Rohan, Kuppan Gokulakrishnan, Coimbatore Subramanian Shanthi Rani, Mohan Deepa, Ranjit Mohan Anjana, Viswanathan Mohan, Rajendra Pradeepa
AIMS: To determine the prevalence of vitamin B12 deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. METHODS: A total of 1500 individuals [900 normal glucose tolerance (NGT), 300 prediabetes and 300 type 2 diabetes (T2DM)] who were not on vitamin B12 supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study (CURES) follow-up study. Anthropometric, clinical and biochemical investigations, which included vitamin B12 , insulin, homocysteine, HbA1c and serum lipids, were measured...
October 13, 2018: Acta Diabetologica
Tom Walker
We are living through a demographic transition from a world in which there were lots of young people and very few older adults to one in which the numbers in these age groups are becoming more evenly balanced. One reason for this is that more of us are living into our seventies, eighties, nineties, and beyond. That is the good news. Unfortunately, the chance of developing chronic illnesses (including diabetes, arthritis, and dementia) is typically higher for people in these older age groups than for those who are younger...
September 2018: Hastings Center Report
Krishnamoorthy Vijayalakshmi, Chinnadurai Immanuel Selvaraj
Nature has gifted us with abundant plants possessing medicinal virtues which can cure several illnesses. Currently, diabetes mellitus is a severe threat to human well-being across the world due to the rapidly increasing incidence of diabetes. New effective bioactive drugs are in need, as plants do harbour and are proven to have potential antidiabetic activity than the present hypoglycemic medicines used in clinical therapy. In this study, in vitro cytotoxicity, glucose uptake, and anti-adipogenic activities of the plant extract (methanolic extract) of S...
October 11, 2018: Molecular Biology Reports
Chaitanya K Gavini, Angie L Bookout, Raiza Bonomo, Laurent Gautron, Syann Lee, Virginie Mansuy-Aubert
Obesity is associated with many complications, including type 2 diabetes and painful neuropathy. There is no cure or prevention for obesity-induced pain, and the neurobiology underlying the onset of the disease is still obscure. In this study, we observe that western diet (WD)-fed mice developed early allodynia with an increase of ER stress markers in the sensory neurons of the dorsal root ganglia (DRG). Using cell-specific approaches, we demonstrate that neuronal liver X receptor (LXR) activation delays ER stress and allodynia in WD-fed mice...
October 9, 2018: Cell Reports
Serap Gur, Asim B Abdel-Mageed, Suresh C Sikka, Wayne J G Hellstrom
Stem cell (SC) application is a promising area of research in regenerative medicine, with the potential to treat, prevent, and cure disease. In recent years, the number of studies focusing on SCs for the treatment of erectile dysfunction (ED) and other sexual dysfunctions has increased significantly. Areas covered: This review includes critical ED targets and preclinical studies, including the use of SCs and animal models in diabetes, aging, cavernous nerve injury, and Peyronie's disease. A literature search was performed on PubMed for English articles...
October 9, 2018: Expert Opinion on Biological Therapy
Muhammad Farrukh Nisar, Junwei He, Arsalan Ahmed, Youxin Yang, Mingxi Li, Chunpeng Wan
Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males and females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, and tumors), confectionaries, food industry, and in some pesticides...
October 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Y Y Hong, G B Lin, C Lin, S N Ye
Objective: To identify the clinical risk factors related to the increased likelihood of surgical drainage and medical therapy failure in parapharyngeal and retropharyngeal abscess. Method: The charts of 93 consecutive patients from January 2006 to April 2017 with parapharyngeal and retropharyngeal abscess were reviewed retrospectively. Logistic regression analysis was used to study the clinical risk factors. Result: A total of 97 adult patients, there were 34 cases in the immediate surgical drainage group and 32 cases in the delayed surgical drainage group and 31 cases treated with medical therapy alone...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Lun Wang, Tao Jiang, Jinfa Wang
With the development of social economy and the change of lifestyle and working environment, the number of obese and diabetic population has increased significantly. Obesity is closely related to diabetes mellitus with interaction. Among the patients with type 1 diabetes mellitus (T1DM), the cardiovascular risk of T1DM with obesity is significantly higher than those of lean T1DM. The mortality of T1DM with obesity is significantly higher than that of the general population, which poses a great threat to human health, making it become one of the serious public health problems we have to face at present...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Mani Panagal, M Biruntha, R M Vidhyavathi, P Sivagurunathan, S R Senthilkumar, Durairaj Sekar
Stroke is an important neurological disease in which blood flow to the brain is interrupted and it is becoming an increasing non-communicable disease in developing countries. Current treatment options for stroke is modifying lifestyle practice, diabetes treatment, drugs, and other factors management, but yet no cure is available in sight for the disease, despite it requires new insight into the molecular and therapeutic targets. In general, MicroRNAs (miRNAs) are small noncoding RNAs considered as of greater biological importance and controls molecular signaling pathways in diabetic pathogenesis...
September 26, 2018: Gene
Masaki Miura, Takeshi Miyatsuka, Takehiro Katahira, Shugo Sasaki, Luka Suzuki, Miwa Himuro, Yuya Nishida, Yoshio Fujitani, Taka-Aki Matsuoka, Hirotaka Watada
BACKGROUND: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. METHODS: The role of STAT3 in β-cell neogenesis, induced by the exogenous expression of Pdx1, Neurog3, and Mafa, was analyzed in vitro and in vivo. FINDINGS: The expression of phosphorylated STAT3 (pSTAT3) was induced in both Pdx1-expressing and Mafa-expressing cells, but most of the induced β cells were negative for pSTAT3...
September 25, 2018: EBioMedicine
Htay Htay, Jun Jie B Seng, Mei Hui A Yong, Suh Chien Pang, Sin Yan Wu, Choong M Chan, Mui Hian Sim, David W Johnson, Marjorie Wai Yin Foo
BACKGROUND: The incidence of elderly patients receiving peritoneal dialysis (PD) has increased. This study aimed to examine the clinical presentation and outcomes of peritonitis in elderly PD patients compared with younger PD patients. METHODS: This single-center, retrospective, observational cohort study included all adult PD patients who developed peritonitis between January 2011 and December 2014. Elderly was defined as ≥ 65 years old at PD initiation. The primary outcome was medical cure, defined as a peritonitis episode cured by antibiotics without being complicated by catheter removal, transfer to hemodialysis (HD), relapsing peritonitis,or death...
September 25, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Georgia E Fouli, Luigi Gnudi
Diabetic nephropathy is the commonest cause of end-stage renal disease and affects between 30 and 45% of patients with diabetes mellitus. There is no cure for diabetic nephropathy and the current management of this condition includes glycaemic control, blockade of the renin-angiotensin aldosterone system and lifestyle changes. However, many patients eventually progress to end-stage renal disease. The exact pathogenesis of diabetic nephropathy is still being researched, and recent advances have led to the development of several novel potential therapeutic targets...
September 26, 2018: Nephron
Shengxue Hu, Xianqun Cai, Xin Qu, Bangrui Yu, Chenyan Yan, Jianmin Yang, Feng Li, Yunquan Zheng, Xianai Shi
Wound dressings with long-term antimicrobial activity are highly desired for treatment of chronic wound infections. Herein, the sustained antimicrobial wound dressings were developed by using antibiotic agents, ciprofloxacin HCL (CIP) and gentamicin sulfate (GS), covalent bonding to natural polymer matrix composites, carboxymethyl chitosan (CMC) and collagen (COL). By amide bond formation between antibiotic agents and polymer chains, two antimicrobial wound dressings CMC-COL-CIP and CMC-COL-GS were prepared...
September 21, 2018: International Journal of Biological Macromolecules
Wenqiang He, Linling Yan, Meng Wang, Qin Li, Min He, Zengyi Ma, Zhao Ye, Qilin Zhang, Yichao Zhang, Nidan Qiao, Yun Lu, Hongying Ye, Bin Lu, Xuefei Shou, Yao Zhao, Yiming Li, Shiqi Li, Zhaoyun Zhang, Ming Shen, Yongfei Wang
PURPOSE: The surgical outcome on glucose metabolism in acromegaly patients is not fully understood. We aimed to investigate the impact of surgery on glucose metabolism and identify key factors that influence alterations of glucose metabolic status in acromegaly patients. METHODS: Oral glucose tolerance test was performed in 151 newly diagnosed acromegaly patients before and 3-12 months after surgery. Insulin resistance and insulin secretion was assessed. Patients were grouped as cured, discordant, and having active disease according to postoperative growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels...
September 20, 2018: Endocrine
Andrea Peloso, Antonio Citro, Tamara Zoro, Lorenzo Cobianchi, Arianna Kahler-Quesada, Carlo M Bianchi, Axel Andres, Ekaterine Berishvili, Lorenzo Piemonti, Thierry Berney, Christian Toso, Graziano Oldani
According to the Juvenile Diabetes Research Foundation (JDRF), almost 1. 25 million people in the United States (US) have type 1 diabetes, which makes them dependent on insulin injections. Nationwide, type 2 diabetes rates have nearly doubled in the past 20 years resulting in more than 29 million American adults with diabetes and another 86 million in a pre-diabetic state. The International Diabetes Ferderation (IDF) has estimated that there will be almost 650 million adult diabetic patients worldwide at the end of the next 20 years (excluding patients over the age of 80)...
2018: Frontiers in Endocrinology
A Hussain, S El-Hasani
BACKGROUND: One anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) is considered an alternative option in metabolic and bariatric surgery. The aim of this study was to evaluate the safety, efficacy and postoperative challenges of OAGB/MGB as a new procedure. METHODS: We performed 519 primary MGBs and 8 additional second-stage MGBs during 2014-2018. The data were collected from patients' notes as well as the surgeons' prospective data sheets. Two senior surgeons performed the operations...
September 19, 2018: Obesity Surgery
Zhe Jiang, Zekuan Yu, Shouxin Feng, Zhiyu Huang, Yahui Peng, Jianxin Guo, Qiushi Ren, Yanye Lu
BACKGROUND: Fundus fluorescein angiography (FFA) imaging is a standard diagnostic tool for many retinal diseases such as age-related macular degeneration and diabetic retinopathy. High-resolution FFA images facilitate the detection of small lesions such as microaneurysms, and other landmark changes, in the early stages; this can help an ophthalmologist improve a patient's cure rate. However, only low-resolution images are available in most clinical cases. Super-resolution (SR), which is a method to improve the resolution of an image, has been successfully employed for natural and remote sensing images...
September 19, 2018: Biomedical Engineering Online
Ruiyi Yang, Lu Wang, Jie Xie, Xiang Li, Shan Liu, Shengxiang Qiu, Yingjie Hu, Xiaoling Shen
The present study investigated the effects of cajanonic acid A (CAA), extracted from the leaves of Cajanus cajan (L.) Millsp with a purity of 98.22%, on the regulatory mechanisms of glucose and lipid metabolism. HepG2 cells transfected with a protein‑tyrosine phosphatase 1B (PTP1B) overexpression plasmid were established. The cells, induced with insulin resistance by dexamethasone (Dex) treatment, together with type 2 diabetes mellitus (T2DM) model rats and ob/ob mice, were used in the present study. The effects of CAA treatment on the differentiation of 3T3‑L1 adipocytes were determined using Oil Red O...
November 2018: International Journal of Molecular Medicine
T Wu, H Zhou, H T Gu, J Y Zhou
Objective: To analyze high risk factors, therapeutic regimen and prognosis of patients with pulmonary mucormycosis. Methods: A retrospective analysis was performed on the clinical data of 25 patients who were diagnosed as pulmonary mucormycosis in the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2009 and December 2017. Results: Univariate analysis revealed that no risk factor had significant effect on prognosis of these 25 cases, while multivariate logistic regression analysis confirmed that the exposure to antifungal drugs was correlated to worse prognosis( P =0...
August 28, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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