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Diabetes Cure

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https://www.readbyqxmd.com/read/30538978/models-for-predicting-time-to-sputum-conversion-among-multi-drug-resistant-tuberculosis-patients-in-lagos-south-west-nigeria
#1
Oluwatosin J Akinsola, Oyindamola B Yusuf, Olusoji Mayowa Ige, Patrick E Okonji
Background: Multi-drug resistant tuberculosis (MDR-TB) develops due to problems such as irregular drug supply, poor drug quality, inappropriate prescription, and poor adherence to treatment. These factors allow the development and subsequent transmission of resistant strains of the pathogen. However, due to the chronic nature of MDR-TB, cure models allow us to investigate the covariates that are associated with the long-term effects of time-to-sputum conversion among multi-drug resistant (MDR-TB) tuberculosis individuals...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/30538603/care-of-patients-following-cure-of-hepatitis-c-virus-infection
#2
Norah A Terrault
The vast majority of persons with chronic hepatitis C virus (HCV) infection will achieve virologic cure with the current direct-acting antiviral therapies. Prevention of reinfection is an important aspect of postcure management and key to the elimination of HCV infection globally. Equally important aspects of postcure care are the prevention of liver disease progression and the management of complications in patients who have significant fibrosis at the time of achieving cure. Patients with advanced fibrosis need to remain under surveillance for liver complications, including hepatocellular carcinoma...
November 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30531665/-surgical-treatment-of-obesity-from-the-nutritional-point-opportunities-and-dangers
#3
EDITORIAL
Natalia Komorniak, Ewa Stachowska
Obesity is a civilization disease, which occurrence in the world population is gradually increasing. The basic causes of obesity include a sedentary lifestyle and energy-rich diet contributing to a positive energy balance. Methods of curing obesity contain the lifestyle modification, the pharmacological treatment and the surgical treatment. The bariatric surgery is a therapy that can be used among patients with BMI ≥40 or BMI ≥35 kg/m2 with comorbidities, e.g. hypertension, for whom previous treatment has been ineffective...
November 28, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/30510843/a-review-of-clinical-trials-mesenchymal-stem-cell-transplant-therapy-in-type-1-and-type-2-diabetes-mellitus
#4
REVIEW
Jang Cho, Matthew D'Antuono, Michael Glicksman, Jing Wang, Jacqueline Jonklaas
Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are widely prevalent metabolic diseases with differing pathologies. T1DM manifests due to autoimmune destruction of the pancreatic beta cells, resulting in a diminished secretion of insulin. T2DM originates from a state of insulin resistance, resulting in hyperglycemia and reduction in beta cell mass. Both diseases can cause severe health consequences. Despite the globally increasing prevalence of both T1DM and T2DM there remains to be a medically defined cure for either of these diseases...
2018: American Journal of Stem Cells
https://www.readbyqxmd.com/read/30484411/identification-of-novel-pancreatic-lipase-inhibitors-using-structure-based-virtual-screening-docking-and-simulations-studies
#5
Umesh Panwar, Sanjeev Kumar Singh
BACKGROUND: Obesity is well known multifactorial disorder towards the public health concern in front of the world. Increasing rates of obesity has characterized with liver diseases, chronic diseases, diabetes mellitus, hypertension, and stroke, hearts improper function, reproductive and gastrointestinal, gallstones. An essential enzyme pancreatic lipase recognized for the digestion and absorption of lipids, can be a pleasing drug target towards the future development of anti-obesity therapeutics in cure of obesity disorders...
November 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/30467752/endocrine-disruption-as-an-adverse-effect-of-non-endocrine-targeting-pharmaceuticals
#6
Shakila Sabir, Muhammad Furqan Akhtar, Ammara Saleem
Endocrine disruptors have gained widespread attention owing to their severe adverse health impacts. These produce enormous burden of disease and are associated with high economic cost especially in developed countries. Environmental pollutants causing endocrine disruption include pesticides, industrial wastes, packaging materials, food constituents, plastics, and cosmetic products. Likewise, pharmaceutical drugs have the endocrine disrupting potential through a wide array of mechanisms. Antipsychotic, antiepileptic, antihypertensive, antiviral, antidiabetic, and anticancer drugs are among the foremost non-hormonal endocrine disruptors...
November 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30453687/scutellariae-radix-and-coptidis-rhizoma-improve-glucose-and-lipid-metabolism-in-t2dm-rats-via-regulation-of-the-metabolic-profiling-and-mapk-pi3k-akt-signaling-pathway
#7
Xiang Cui, Da-Wei Qian, Shu Jiang, Er-Xin Shang, Zhen-Hua Zhu, Jin-Ao Duan
Aim Scutellariae Radix (SR) and Coptidis Rhizoma (CR) have often been combined to cure type 2 diabetes mellitus (T2DM) in the clinical practice for over thousands of years, but their compatibility mechanism is not clear. Mitogen-activated protein kinase (MAPK) signaling pathway has been suggested to play a critical role during the process of inflammation, insulin resistance, and T2DM. This study was designed to investigate their compatibility effects on T2DM rats and explore the underlying mechanisms by analyzing the metabolic profiling and MAPK/PI3K/Akt signaling pathway...
November 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30450940/contribution-of-oxidative-stress-and-impaired-biogenesis-of-pancreatic-%C3%AE-cells-to-type-2-diabetes
#8
Petr Jezek, Martin Jaburek, Lydie Plecita-Hlavata
SIGNIFICANCE: Type 2 diabetes development involves multiple changes inβ-cells, related to the oxidative stress and impaired redox signaling, beginning frequently by sustained overfeeding due to the resulting lipotoxicity and glucotoxicity. Uncovering relations among the dysregulated metabolism, impaired β-cell "well being", biogenesis, or crosstalk with peripheral insulin resistance is required for elucidation of type 2 diabetes etiology. Recent Advances: It has been recognized that the oxidative stress, lipotoxicity and glucotoxocity cannot be separated from numerous other cell pathology events, such as the attempted compensation ofβ-cell for the increased insulin demand and dynamics ofβ-cell biogenesis and its "reversal" at dedifferentiation, i...
November 18, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/30429785/hyperhomocysteinemia-as-a-risk-factor-for-vascular-contributions-to-cognitive-impairment-and-dementia
#9
REVIEW
Brittani R Price, Donna M Wilcock, Erica M Weekman
Behind only Alzheimer's disease, vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia, affecting roughly 10-40% of dementia patients. While there is no cure for VCID, several risk factors for VCID, such as diabetes, hypertension, and stroke, have been identified. Elevated plasma levels of homocysteine, termed hyperhomocysteinemia (HHcy), are a major, yet underrecognized, risk factor for VCID. B vitamin deficiency, which is the most common cause of HHcy, is common in the elderly...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30425764/comparison-of-comorbid-conditions-between-cancer-survivors-and-age-matched-patients-without-cancer
#10
Satyajeet Roy, Shirisha Vallepu, Cristian Barrios, Krystal Hunter
Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72...
December 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30419713/-the-analysis-of-wasting-and-thirst-disease-from-wei-jin-to-tang-dynasty
#11
F Huang, W R Li
Huangdi Neijing ()considered that "wasting-and-thirst" patients should not take mineral drugs. The period from Wei-Jin to Tang Dynasty, to meet the need for mildly strengthening Yang by tonic, people no longer considered that "wasting-and-thirst" patients can't take mineral drugs. It was popular to take mineral elixir. The rich people who consumed mineral elixir were susceptible of diabetes. The practitioners observed that taking mineral elixir and sexual behaviors were related to "wasting-and-thirst" , and therefore, they realized that taking mineral elixir was main cause of getting it...
July 28, 2018: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/30416049/patient-specific-ipsc-derived-endothelial-cells-provide-long-term-phenotypic-correction-of-hemophilia-a
#12
Cristina Olgasi, Maria Talmon, Simone Merlin, Alessia Cucci, Yvonne Richaud-Patin, Gabriella Ranaldo, Donato Colangelo, Federica Di Scipio, Giovanni N Berta, Chiara Borsotti, Federica Valeri, Francesco Faraldi, Maria Prat, Maria Messina, Piercarla Schinco, Angelo Lombardo, Angel Raya, Antonia Follenzi
We generated patient-specific disease-free induced pluripotent stem cells (iPSCs) from peripheral blood CD34+ cells and differentiated them into functional endothelial cells (ECs) secreting factor VIII (FVIII) for gene and cell therapy approaches to cure hemophilia A (HA), an X-linked bleeding disorder caused by F8 mutations. iPSCs were transduced with a lentiviral vector carrying FVIII transgene driven by an endothelial-specific promoter (VEC) and differentiated into bona fide ECs using an optimized protocol...
November 3, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/30396499/the-myth-of-autoimmunity
#13
Gilles R G Monif
Within the more than one hundred disease entities for which autoimmunity causation have been alleged, two subgroups can be identified. The first group is characterized by ability of disruption of the effector arm of the immune response to temporarily reverse the signs and symptoms of disease. The second group is characterized by the presence of antibodies directed against the target organ's cellular or subcellular components. As long as therapeutic palliation of the signs and symptoms of disease can be achieved, attributing causation to autoimmunity has tended to arrest therapeutics focus on attaining cure...
December 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/30373146/the-pathophysiology-of-gestational-diabetes-mellitus
#14
REVIEW
Jasmine F Plows, Joanna L Stanley, Philip N Baker, Clare M Reynolds, Mark H Vickers
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance. Risk factors for GDM include overweight and obesity, advanced maternal age, and a family history or any form of diabetes. Consequences of GDM include increased risk of maternal cardiovascular disease and type 2 diabetes and macrosomia and birth complications in the infant...
October 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30364192/dissecting-the-physiology-and-pathophysiology-of-glucagon-like-peptide-1
#15
REVIEW
Silvano Paternoster, Marco Falasca
An aging world population exposed to a sedentary life style is currently plagued by chronic metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an unprecedented rate. One of the most promising pharmacological approaches for the management of type 2 diabetes takes advantage of the peptide hormone glucagon-like peptide-1 (GLP-1) under the form of protease resistant mimetics, and DPP-IV inhibitors. Despite the improved quality of life, long-term treatments with these new classes of drugs are riddled with serious and life-threatening side-effects, with no overall cure of the disease...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30361313/bad-medicine-a-cure-for-type-2-diabetes
#16
Des Spence
No abstract text is available yet for this article.
November 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/30351236/spontaneous-hepatic-hemorrhage-caused-by-emphysematous-cholecystitis-a-case-report-and-literature-review
#17
Zhoujia Yao, Jun Zheng, Youguang Si, Xudong Xu, Tingting Li
BACKGROUND: Emphysematous cholecystitis and spontaneous hepatic hemorrhage are uncommon and serious conditions with non-specific presentations that can lead to a poor clinical outcome. We report a case of spontaneous hepatic hemorrhage of emphysematous cholecystitis. A 49-year-old male presented to the emergency department with fever, chills, right upper quadrant pain, vomiting, and diarrhea of four days' duration. He had a history of diabetes mellitus, hypertension, and uarthritis. Computed tomography (CT) revealed an enlarged gallbladder with intra-luminal, intra-mural, and peri-cholecystic air; subcapsular high-density fluid collection; and an intra-hepatic mass with gas and liquid in the right lobe of the liver...
October 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/30347747/investigation-of-the-in-vivo-metabolism-of-sibirioside-a-and-angoroside-c-in-rats-by-hplc-esi-it-tof-ms-n
#18
Yi-Fan Zhang, Li-Jia Liu, Feng Xu, Ming-Ying Shang, Guang-Xue Liu, Shao-Qing Cai
Sibirioside A and angoroside C are two important phenylpropanoid glycosides of the traditional Chinese medicine Scrophulariae Radix. High performance liquid chromatography, coupled with an ion trap time-of-flight multistage mass spectrometry equipped with electrospray ionization source (HPLC-ESI-IT-TOF-MSn ), was applied to the profile and we identified the metabolites of sibirioside A and angoroside C in vivo in rats. A total of four metabolites of sibirioside A were identified: SM1, SM2 and SM3 which were known as new compounds...
October 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30343978/surgical-treatment-of-congenital-hyperinsulinism-results-from-500-pancreatectomies-in-neonates-and-children
#19
N Scott Adzick, Diva D De Leon, Lisa J States, Katherine Lord, Tricia R Bhatti, Susan A Becker, Charles A Stanley
BACKGROUND: Congenital Hyperinsulinism (HI) causes severe hypoglycemia in neonates and children. We reviewed our experience with pancreatectomy for the various types of HI. METHODS: From 1998 to 2018, 500 patients with HI underwent pancreatectomy: 246 for focal HI, 202 for diffuse HI, 37 for atypical HI (16 for Localized Islet Nuclear Enlargement [LINE], 21 for Beckwith-Wiedemann Syndrome), and 15 for insulinoma. Focal HI neonates were treated with partial pancreatectomy...
October 5, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30332726/isolation-and-characterization-of-pancreatic-canine-fetal-cells-at-the-final-stage-of-gestation
#20
Bruna Andrade Aguiar, Dailiany Orechio, Paula Fratini, Ana Claudia Oliveira Carreira, Patricia Castelucci, Maria Angelica Miglino
The incidence of diabetes mellitus in dogs is increasing in recent years, mainly because of genetic and/or environmental factors, including endocrine disorders (like in humans); failure of suitable control of blood sugar levels, which triggers hyperglycemia; glycosuria and weight loss, which demands the development of innovative treatments to cure or treat this complex disease in dogs. The present study established for the first time a protocol to obtain and characterize cells derived from pancreas of canine fetuses...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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