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C Santucci, M Franchi, L I Staszewsky, C La Vecchia, R Latini, L Merlino, G Corrao, C Bosetti
BACKGROUND AND AIMS: There are concerns that incretin-based antidiabetic drugs - including dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists - increase the risk of hospitalization for heart failure (HF). To further analyse this issue, we conducted a nested case-control study within a cohort of antidiabetic users in a real world setting. METHODS AND RESULTS: Within a cohort of 133,639 subjects with a first prescription of an antidiabetic drug (new-users) between 2010 and 2016 in Lombardy, Italy, and were followed-up to 2016, we identified 4057 subjects with a first hospitalization for HF and 80,450 controls matched on sex, age, and date of cohort-entry...
October 14, 2018: Diabetes Research and Clinical Practice
Nathan B Fethke, Mark C Schall, Linda A Merlino, Howard Chen, Cassidy A Branch, Maya Ramaswamy
Exposure to whole-body vibration (WBV) is common among agricultural workers and is associated with musculoskeletal health outcomes such as low back pain. Little is known, however, about the characteristics of exposure experienced during actual production practices. We measured WBV levels during agricultural machinery use among a sample of farmers (n = 55) performing routine agricultural activities and explored machinery attributes that may explain WBV summary measures. We also measured trunk posture to provide additional information about physical exposures during machinery operation...
September 20, 2018: Annals of Work Exposures and Health
Abraham G Lin, Bo Xiang, Dante J Merlino, Trevor R Baybutt, Joya Sahu, Alexander Fridman, Adam E Snook, Vandana Miller
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens. In the case of cancer therapy, tumor cells undergoing immunogenic death promote cancer-specific immunity. Identification, characterization, and optimization of stimuli that induce immunogenic cancer cell death has tremendous potential to improve the outcomes of cancer therapy. In this study, we show that non-thermal, atmospheric pressure plasma can be operated to induce immunogenic cell death in an animal model of colorectal cancer...
2018: Oncoimmunology
Luiz Saramago, Helga Gomes, Elena Aguilera, Hugo Cerecetto, Mercedes González, Mauricio Cabrera, Maria Fernanda Alzugaray, Itabajara da Silva Vaz Junior, Rodrigo Nunes da Fonseca, Beatriz Aguirre-López, Nallely Cabrera, Ruy Pérez-Montfort, Alicia Merlino, Jorge Moraes, Guzmán Álvarez
The cattle tick Rhipicephalus microplus is one of the most important ectoparasites causing significant economic losses for the cattle industry. The major tool of control is reducing the number of ticks, applying acaricides in cattle. However, overuse has led to selection of resistant populations of R. microplus to most of these products, some even to more than one active principle. Thus, exploration for new molecules with acaricidal activity in R. microplus has become necessary. Triosephosphate isomerase (TIM) is an essential enzyme in R...
August 23, 2018: Veterinary Sciences
Alfonso Panarello, Nachiket Tapas, Giovanni Merlino, Francesco Longo, Antonio Puliafito
The Internet of Things (IoT) refers to the interconnection of smart devices to collect data and make intelligent decisions. However, a lack of intrinsic security measures makes IoT vulnerable to privacy and security threats. With its "security by design," Blockchain (BC) can help in addressing major security requirements in IoT. BC capabilities like immutability, transparency, auditability, data encryption and operational resilience can help solve most architectural shortcomings of IoT. This article presents a comprehensive survey on BC and IoT integration...
August 6, 2018: Sensors
Silvia Ciambellotti, Alessandro Pratesi, Mirko Severi, Giarita Ferraro, Enzo Alessio, Antonello Merlino, Luigi Messori
The reaction of the antimetastatic ruthenium(iii) drug NAMI A with human H-chain ferritin (HuHf) was investigated through a variety of biophysical methods. We observed that the addition of HuHf to NAMI A solutions significantly increases the rate of spontaneous NAMI A hydrolysis suggesting the occurrence of a direct metallodrug-protein interaction. The resulting hydrolyzed Ru species binds the protein mostly forming a relatively tight 1 : 1 ruthenium/ferritin (subunit) adduct that was then separated and characterized...
August 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Federico Rea, Giovanni Corrao, Luca Merlino, Giuseppe Mancia
Aims: Guidelines support use of drug combinations in most hypertensive patients, and recently treatment initiation with two drugs has been also recommended. However, limited evidence is available on whether this leads to greater cardiovascular (CV) protection compared to initial monotherapy. Methods and results: Using the healthcare utilization database of the Lombardy Region (Italy), the 44 534 residents of the region (age 40-80 years) who in 2010 started treatment with one antihypertensive drug (n = 37 078) or a two-drug fixed-dose combination (FDC, n = 7456) were followed for 1 year after treatment initiation to compare the risk of hospitalization for CV disease associated with the two treatment strategies...
July 27, 2018: European Heart Journal
Giarita Ferraro, Ahmed M Mansour, Antonello Merlino
Pd(ii) and Pt(ii) compounds bearing N,N-pyridylbenzimidazole derivatives with an alkylated sulfonate or phosphonium side chain are able to bind the model protein lysozyme both covalently and non-covalently as an entire compound or as a product of a hydrolysis reaction. The interactions with the protein and the origin of the different behaviors of these complexes were unknown hitherto. Here, we present four crystal structures of their adducts with lysozyme. Pt- and Pd-containing fragments bind the protein with different stoichiometries close to the side chains of His15, Asp87, Asp101 and Asn77...
July 31, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sarah E Tevis, Ted A James, Henry M Kuerer, Andrea L Pusic, Katharine A Yao, James Merlino, Jill Dietz
Patient-reported outcomes (PROs) provide insight into how patients perceive health and treatment effects, how treatments impact outcomes, and are helpful in determining how disease and surgical interventions impact many aspects of a patients' life. Commonly utilized metrics include survival and disease control, degree of recovery and functional status, access to treatment, treatment-related complications, health-related quality of life, and long-term consequences of therapy. The key to value-based, patient-centered health care is systematically incorporating patient input into the measures that they consider to be the most important outcomes for a particular medical condition while minimizing costs of care...
October 2018: Annals of Surgical Oncology
Shuai Li, Shengwu Liu, Jiehui Deng, Esra A Akbay, Josephine Hai, Chiara Ambrogio, Long Zhang, Fangyu Zhou, Russell W Jenkins, Dennis O Adeegbe, Peng Gao, Xiaoen Wang, Cloud P Paweletz, Grit S Herter-Sprie, Ting Chen, Laura Gutiérrez-Quiceno, Yanxi Zhang, Ashley A Merlino, Max M Quinn, Yu Zeng, Xiaoting Yu, Yuting Liu, Lichao Fan, Andrew J Aguirre, David A Barbie, Xianghua Yi, Kwok-Kin Wong
Purpose: Despite the challenge to directly target mutant KRAS due to its high GTP affinity, some agents are under development against downstream signaling pathways, such as MEK inhibitors. However, it remains controversial whether MEK inhibitors can boost current chemotherapy in KRAS -mutant lung tumors in clinic. Considering the genomic heterogeneity among patients with lung cancer, it is valuable to test potential therapeutics in KRAS mutation-driven mouse models. Experimental Design: We first compared the pERK1/2 level in lung cancer samples with different KRAS substitutions and generated a new genetically engineered mouse model whose tumor was driven by KRAS G12C , the most common KRAS mutation in lung cancer...
October 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Benedetta Riva, Antonio Clavenna, Massimo Cartabia, Angela Bortolotti, Ida Fortino, Luca Merlino, Andrea Biondi, Maurizio Bonati
Objectives: To estimate the rate of paediatric attendance at emergency departments (EDs) in the Lombardy Region, Italy, and to determine the factors contributing to different patterns of use. Methods: By analysing healthcare administrative databases, ED attendance by 1.6 million youths <18 years old during 2012 in the Lombardy Region was assessed. The pattern of use was categorised based on the number of ED visits and level of emergency, defined by triage code and outcome of the visit...
2018: BMJ Paediatrics Open
Anna Cantarutti, Matteo Franchi, Federico Rea, Luca Merlino, Giovanni Corrao
INTRODUCTION: Nimesulide is the most prescribed non-steroidal anti-inflammatory drug in Italy, and it is currently marketed in about 50 countries worldwide. The association between the use of nimesulide in early pregnancy and the risk of birth defects was investigated in a large cohort of pregnant women from Italy. METHODS: Data were from the healthcare utilization databases of the Italian region of Lombardy. The cohort of 353,081 newborns occurring in Lombardy during the period 2005-2010 was investigated...
June 19, 2018: Advances in Therapy
Giuliana Banche, Alessandro Bistolfi, Valeria Allizond, Claudia Galletta, Maria Rita Iannantuoni, Elisa Simona Marra, Chiara Merlino, Alessandro Massè, Anna Maria Cuffini
Prosthetic joint infection diagnosis is often difficult since biofilm-embedded microorganisms attach well to the prosthetic surfaces and resist their detection by conventional methods. DL-dithiothreitol has been described as a valid method for biofilm detachment on orthopedic devices. We report the case of an occasional detection of Listeria monocytogenes in a non immuno-compromised patient with a preoperative diagnosis of aseptic loosening. The infection diagnosis due to such rare bacteria was made postoperatively, thanks to a DL-dithiothreitol-based device...
September 2018: Future Microbiology
Manuel Cappellari, Gianni Turcato, Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Bruno Bonetti, Giovanni Merlino, Roberto Eleopra, Monia Russo, Roberto L'Erario, Alessandro Adami, Carolina Gentile, Anna Gaudenzi, Sandro Bruno, Paolo Bovi
In clinical practice, direct oral anticoagulants (DOACs) are often started earlier (≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the probability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1-7 days after atrial fibrillation-related stroke onset...
October 2018: Journal of Thrombosis and Thrombolysis
Giuseppe Merlino, Alan Barozzi, Grégoire Michoud, David Kamanda Ngugi, Daniele Daffonchio
Deep hypersaline anoxic basins (DHABs) are unique water bodies occurring within fractures at the bottom of the sea, where the dissolution of anciently buried evaporites created dense anoxic brines that are separated by a chemocline/pycnocline from the overlying oxygenated deep-seawater column. DHABs have been described in the Gulf of Mexico, the Mediterranean Sea, the Black Sea and the Red Sea. They are characterized by prolonged historical separation of the brines from the upper water column due to lack of mixing and by extreme conditions of salinity, anoxia, and relatively high hydrostatic pressure and temperatures...
July 1, 2018: FEMS Microbiology Ecology
Giarita Ferraro, Tiziano Marzo, Teresa Infrasca, Agostino Cilibrizzi, Ramon Vilar, Luigi Messori, Antonello Merlino
An antiproliferative platinum(ii)-terpyridine complex bearing two piperidine substituents at positions 2 and 2' (compound 1, hereafter) interacts non-covalently with DNA and induces cell death through necrosis, i.e. a mode of action that is distinct from that exhibited by cisplatin (Suntharalingam, et al., Metallomics, 2013, 5, 514). Here, the interaction between this Pt compound and the model protein hen egg white lysozyme (HEWL) was studied by both electrospray ionization mass spectrometry (ESI MS) and X-ray crystallography...
July 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Alice Giovacchini, Silvia Merlino, Marina Locritani, Mascha Stroobant
Our paper will show data on quantity, typology, distribution of beach litter (Anthropogenic Marine Debris - AMD) within a coastal macroarea surrounding the Pelagos Sanctuary, an International Protected Area in the NW Mediterranean Sea. AMD Monitoring and characterisation have been performed by using SEACleaner Protocol: an adapted version of UNEP/IOC, OSPAR and EU guidelines. 11 beaches located in 5 different areas, have been monitored with a total amount of thirty three surveys, from January 2014 to December 2015, during different seasons...
May 2018: Marine Pollution Bulletin
Grazia Rutigliano, Sergio Merlino, Amedeo Minichino, Rashmi Patel, Cathy Davies, Dominic Oliver, Andrea De Micheli, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Acute and transient psychotic disorders (ATPD) are characterized by an acute onset and a remitting course, and overlap with subgroups of the clinical high-risk state for psychosis. The long-term course and outcomes of ATPD are not completely clear. METHODS: Electronic health record-based retrospective cohort study, including all patients who received a first index diagnosis of ATPD (F23, ICD-10) within the South London and Maudsley (SLaM) National Health Service Trust, between 1 st April 2006 and 15th June 2017...
August 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Francesco Merlino, Simona Daniele, Valeria La Pietra, Salvatore Di Maro, Francesco Saverio Di Leva, Diego Brancaccio, Stefano Tomassi, Stefano Giuntini, Linda Cerofolini, Marco Fragai, Claudio Luchinat, Florian Reichart, Chiara Cavallini, Barbara Costa, Rebecca Piccarducci, Sabrina Taliani, Federico Da Settimo, Claudia Martini, Horst Kessler, Ettore Novellino, Luciana Marinelli
In the fight against Glioblastoma Multiforme, recent literature data have highlighted that integrin α5β1 and p53 are part of convergent pathways in the control of glioma apoptosis. This observation prompted us to seek a molecule able to simultaneously modulate both target families. Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4. Herein, we present the discovery of compound 7, which inhibits both MDM2/4 and α5β1/αvβ3 integrins...
June 14, 2018: Journal of Medicinal Chemistry
Sara Grassi, Mario Merlino, Renato Rosso, Giovanni Borroni
No abstract text is available yet for this article.
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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