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Ramona Marasco, María J Mosqueira, Marco Fusi, Jean-Baptiste Ramond, Giuseppe Merlino, Jenny M Booth, Gillian Maggs-Kölling, Don A Cowan, Daniele Daffonchio
BACKGROUND: The rhizosheath-root system is an adaptive trait of sandy-desert speargrasses in response to unfavourable moisture and nutritional conditions. Under the deserts' polyextreme conditions, plants interact with edaphic microorganisms that positively affect their fitness and resistance. However, the trophic simplicity and environmental harshness of desert ecosystems have previously been shown to strongly influence soil microbial community assembly. We hypothesize that sand-driven ecological filtering constrains the microbial recruitment processes in the speargrass rhizosheath-root niche, prevailing over the plant-induced selection...
December 4, 2018: Microbiome
Giarita Ferraro, Andrea Pica, Ganna Petruk, Francesca Pane, Angela Amoresano, Agostino Cilibrizzi, Ramon Vilar, Daria Maria Monti, Antonello Merlino
AIM: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2' of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). MATERIALS & METHODS: Spectroscopic and crystallographic data of the Pt(II)-AFt nanocomposite have been collected and in vitro anticancer activity has been explored using cancer cells. RESULTS: Pt(II)-containing fragments bind His49, His114 and His132...
December 3, 2018: Nanomedicine
Julie Boudet, Marielle Merlino, Anne Plessis, Jean-Charles Gaudin, Mireille Dardevet, Sibille Perrochon, David Alvarez, Thierry Risacher, Pierre Martre, Catherine Ravel
The quality of wheat grain is mainly determined by the quantity and composition of its grain storage proteins (GSPs). GSPs consist of the low (LMW-GS) and high (HMW-GS) molecular-weight glutenins and gliadins. The synthesis of these proteins is essentially regulated at the transcriptional level and by the availability of nitrogen and sulfur. The regulation network has been extensively studied in barley where BLZ1 and BLZ2, members of the basic leucine zipper (bZIP) family, activate the synthesis of hordeins...
November 16, 2018: Plant Journal: for Cell and Molecular Biology
Pietro Casartelli, Antonio Clavenna, Massimo Cartabia, Angela Bortolotti, Ida Fortino, Luca Merlino, Andrea Biondi, Maurizio Bonati
Objectives: To evaluate the diagnostic and therapeutic approaches in a cohort of asthmatic children before and after starting drug therapy. Methods: Data were retrieved from administrative databases of the Lombardy Region. The study population was composed of 78 184 children born in the Lombardy Region in 2002 and followed until their 10th birthday.Children with at least one antiasthmatic drug prescription per year (with the exclusion of nebulised suspension/solution formulations) in 2 consecutive years and at least one antiasthmatic drug prescription after the fifth birthday were identified as potential asthmatics (PA)...
2018: BMJ Paediatrics Open
Marco Bianucci, Antonietta Capotondi, Silvia Merlino, Riccardo Mannella
El Niño Southern Oscillation (ENSO) is the leading mode of tropical Pacific variability at interannual timescales. Through atmospheric teleconnections, ENSO exerts large influences worldwide, so that improved understanding of this phenomenon can be of critical societal relevance. Extreme ENSO events, in particular, have been associated with devastating weather events in many parts of the world, so that the ability to assess their frequency and probability of occurrence is extremely important. In this study, we describe the ENSO phenomenon in terms of the Recharge Oscillator Model perturbed by multiplicative deterministic chaotic forcing, and use methodologies from the field of Statistical Mechanics to determine the average time between El Niño events of given strengths...
October 2018: Chaos
Giovanni A Chiariello, Piergiorgio Bruno, Federico Cammertoni, Natalia Pavone, Andrea Mazza, Biagio Merlino, Massimo Massetti
No abstract text is available yet for this article.
September 29, 2018: Journal of Thoracic and Cardiovascular Surgery
Federico Rea, Giovanni Corrao, Luca Merlino, Giuseppe Mancia
In many hypertensive patients, treatment is not upgraded despite lack of blood pressure control because of therapeutic inertia. Information is limited, however, on the extent of this phenomenon in real-life medicine. We studied 125 635 patients (age 40-85 years) from the Lombardy region (Italy) who started antihypertensive treatment with 1 drug (n=100 982) or a 2-drug fixed-dose or free combination (n=24 653). A log-binomial regression model was used to estimate the prevalence ratio of combination therapy in relation to the initial treatment strategy...
October 2018: Hypertension
Federico Cammertoni, Piergiorgio Bruno, Giovanni Alfonso Chiariello, Biagio Merlino, Andrea Mazza, Natalia Pavone, Marialisa Nesta, Mauro Iafrancesco, Christian Colizzi, Massimo Massetti
No abstract text is available yet for this article.
September 2018: Circulation. Cardiovascular Imaging
C Santucci, M Franchi, L Staszewsky, C La Vecchia, R Latini, L Merlino, G Corrao, C Bosetti
BACKGROUND AND AIMS: There are concerns that incretin-based antidiabetic drugs - including dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists - increase the risk of hospitalization for heart failure (HF). To further analyse this issue, we conducted a nested case-control study within a cohort of antidiabetic users in a real world setting. METHODS AND RESULTS: Within a cohort of 133,639 subjects with a first prescription of an antidiabetic drug (new-users) between 2010 and 2016 in Lombardy, Italy, and were followed-up to 2016, we identified 4057 subjects with a first hospitalization for HF and 80,450 controls matched on sex, age, and date of cohort-entry...
October 14, 2018: Diabetes Research and Clinical Practice
Nathan B Fethke, Mark C Schall, Linda A Merlino, Howard Chen, Cassidy A Branch, Maya Ramaswamy
Exposure to whole-body vibration (WBV) is common among agricultural workers and is associated with musculoskeletal health outcomes such as low back pain. Little is known, however, about the characteristics of exposure experienced during actual production practices. We measured WBV levels during agricultural machinery use among a sample of farmers (n = 55) performing routine agricultural activities and explored machinery attributes that may explain WBV summary measures. We also measured trunk posture to provide additional information about physical exposures during machinery operation...
September 20, 2018: Annals of Work Exposures and Health
Abraham G Lin, Bo Xiang, Dante J Merlino, Trevor R Baybutt, Joya Sahu, Alexander Fridman, Adam E Snook, Vandana Miller
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens. In the case of cancer therapy, tumor cells undergoing immunogenic death promote cancer-specific immunity. Identification, characterization, and optimization of stimuli that induce immunogenic cancer cell death has tremendous potential to improve the outcomes of cancer therapy. In this study, we show that non-thermal, atmospheric pressure plasma can be operated to induce immunogenic cell death in an animal model of colorectal cancer...
2018: Oncoimmunology
Luiz Saramago, Helga Gomes, Elena Aguilera, Hugo Cerecetto, Mercedes González, Mauricio Cabrera, Maria Fernanda Alzugaray, Itabajara da Silva Vaz Junior, Rodrigo Nunes da Fonseca, Beatriz Aguirre-López, Nallely Cabrera, Ruy Pérez-Montfort, Alicia Merlino, Jorge Moraes, Guzmán Álvarez
The cattle tick Rhipicephalus microplus is one of the most important ectoparasites causing significant economic losses for the cattle industry. The major tool of control is reducing the number of ticks, applying acaricides in cattle. However, overuse has led to selection of resistant populations of R. microplus to most of these products, some even to more than one active principle. Thus, exploration for new molecules with acaricidal activity in R. microplus has become necessary. Triosephosphate isomerase (TIM) is an essential enzyme in R...
August 23, 2018: Veterinary Sciences
Alfonso Panarello, Nachiket Tapas, Giovanni Merlino, Francesco Longo, Antonio Puliafito
The Internet of Things (IoT) refers to the interconnection of smart devices to collect data and make intelligent decisions. However, a lack of intrinsic security measures makes IoT vulnerable to privacy and security threats. With its "security by design," Blockchain (BC) can help in addressing major security requirements in IoT. BC capabilities like immutability, transparency, auditability, data encryption and operational resilience can help solve most architectural shortcomings of IoT. This article presents a comprehensive survey on BC and IoT integration...
August 6, 2018: Sensors
Silvia Ciambellotti, Alessandro Pratesi, Mirko Severi, Giarita Ferraro, Enzo Alessio, Antonello Merlino, Luigi Messori
The reaction of the antimetastatic ruthenium(iii) drug NAMI A with human H-chain ferritin (HuHf) was investigated through a variety of biophysical methods. We observed that the addition of HuHf to NAMI A solutions significantly increases the rate of spontaneous NAMI A hydrolysis suggesting the occurrence of a direct metallodrug-protein interaction. The resulting hydrolyzed Ru species binds the protein mostly forming a relatively tight 1 : 1 ruthenium/ferritin (subunit) adduct that was then separated and characterized...
August 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Federico Rea, Giovanni Corrao, Luca Merlino, Giuseppe Mancia
Aims: Guidelines support use of drug combinations in most hypertensive patients, and recently treatment initiation with two drugs has been also recommended. However, limited evidence is available on whether this leads to greater cardiovascular (CV) protection compared to initial monotherapy. Methods and results: Using the healthcare utilization database of the Lombardy Region (Italy), the 44 534 residents of the region (age 40-80 years) who in 2010 started treatment with one antihypertensive drug (n = 37 078) or a two-drug fixed-dose combination (FDC, n = 7456) were followed for 1 year after treatment initiation to compare the risk of hospitalization for CV disease associated with the two treatment strategies...
October 21, 2018: European Heart Journal
Giarita Ferraro, Ahmed M Mansour, Antonello Merlino
Pd(ii) and Pt(ii) compounds bearing N,N-pyridylbenzimidazole derivatives with an alkylated sulfonate or phosphonium side chain are able to bind the model protein lysozyme both covalently and non-covalently as an entire compound or as a product of a hydrolysis reaction. The interactions with the protein and the origin of the different behaviors of these complexes were unknown hitherto. Here, we present four crystal structures of their adducts with lysozyme. Pt- and Pd-containing fragments bind the protein with different stoichiometries close to the side chains of His15, Asp87, Asp101 and Asn77...
July 31, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sarah E Tevis, Ted A James, Henry M Kuerer, Andrea L Pusic, Katharine A Yao, James Merlino, Jill Dietz
Patient-reported outcomes (PROs) provide insight into how patients perceive health and treatment effects, how treatments impact outcomes, and are helpful in determining how disease and surgical interventions impact many aspects of a patients' life. Commonly utilized metrics include survival and disease control, degree of recovery and functional status, access to treatment, treatment-related complications, health-related quality of life, and long-term consequences of therapy. The key to value-based, patient-centered health care is systematically incorporating patient input into the measures that they consider to be the most important outcomes for a particular medical condition while minimizing costs of care...
October 2018: Annals of Surgical Oncology
Shuai Li, Shengwu Liu, Jiehui Deng, Esra A Akbay, Josephine Hai, Chiara Ambrogio, Long Zhang, Fangyu Zhou, Russell W Jenkins, Dennis O Adeegbe, Peng Gao, Xiaoen Wang, Cloud P Paweletz, Grit S Herter-Sprie, Ting Chen, Laura Gutiérrez-Quiceno, Yanxi Zhang, Ashley A Merlino, Max M Quinn, Yu Zeng, Xiaoting Yu, Yuting Liu, Lichao Fan, Andrew J Aguirre, David A Barbie, Xianghua Yi, Kwok-Kin Wong
Purpose: Despite the challenge to directly target mutant KRAS due to its high GTP affinity, some agents are under development against downstream signaling pathways, such as MEK inhibitors. However, it remains controversial whether MEK inhibitors can boost current chemotherapy in KRAS -mutant lung tumors in clinic. Considering the genomic heterogeneity among patients with lung cancer, it is valuable to test potential therapeutics in KRAS mutation-driven mouse models. Experimental Design: We first compared the pERK1/2 level in lung cancer samples with different KRAS substitutions and generated a new genetically engineered mouse model whose tumor was driven by KRAS G12C , the most common KRAS mutation in lung cancer...
October 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Benedetta Riva, Antonio Clavenna, Massimo Cartabia, Angela Bortolotti, Ida Fortino, Luca Merlino, Andrea Biondi, Maurizio Bonati
Objectives: To estimate the rate of paediatric attendance at emergency departments (EDs) in the Lombardy Region, Italy, and to determine the factors contributing to different patterns of use. Methods: By analysing healthcare administrative databases, ED attendance by 1.6 million youths <18 years old during 2012 in the Lombardy Region was assessed. The pattern of use was categorised based on the number of ED visits and level of emergency, defined by triage code and outcome of the visit...
2018: BMJ Paediatrics Open
Anna Cantarutti, Matteo Franchi, Federico Rea, Luca Merlino, Giovanni Corrao
INTRODUCTION: Nimesulide is the most prescribed non-steroidal anti-inflammatory drug in Italy, and it is currently marketed in about 50 countries worldwide. The association between the use of nimesulide in early pregnancy and the risk of birth defects was investigated in a large cohort of pregnant women from Italy. METHODS: Data were from the healthcare utilization databases of the Italian region of Lombardy. The cohort of 353,081 newborns occurring in Lombardy during the period 2005-2010 was investigated...
June 19, 2018: Advances in Therapy
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