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Estêvão Scotti-Muzzi, Osvaldo Luis Saide
The presence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorders (OCD) in schizophrenia is frequent, and a new clinical entity has been proposed for those who show the dual diagnosis: the schizo-obsessive disorder. This review scrutinizes the literature across the main academic databases, and provides an update on different aspects of schizo-obsessive spectrum disorders, which include schizophrenia, schizotypal personality disorder (SPD) with OCD, OCD with poor insight, schizophrenia with OCS, and schizophrenia with OCD (schizo-obsessive disorder)...
September 27, 2016: CNS Spectrums
Rebecca C Hanna, Jessica M Perez, Subroto Ghose
BACKGROUND: The use of cannabis has garnered more attention recently with ongoing efforts at marijuana legalization. The consequences of cannabis use are not clearly understood and remain a concern. OBJECTIVES: To review the acute and persistent effects of cannabis use and associations with psychiatric disorders. METHODS: Using Pubmed and PsychInfo, we conducted a narrative review of the literature on cannabis and psychiatric comorbidity using the keywords cannab*, marijuana, schizo*, psychosis, mood, depression, mania, bipolar, and anxiety...
September 9, 2016: American Journal of Drug and Alcohol Abuse
Madhavi K Ganapathiraju, Mohamed Thahir, Adam Handen, Saumendra N Sarkar, Robert A Sweet, Vishwajit L Nimgaonkar, Christine E Loscher, Eileen M Bauer, Srilakshmi Chaparala
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein interactions (PPIs) are unknown for many of the liability genes. We developed a computational model to discover PPIs, which is found to be highly accurate according to computational evaluations and experimental validations of selected PPIs...
2016: NPJ Schizophrenia
Asma Ben Houidi, Faten Ellouze, Mona Ben Djebara, Youssef Sidhom, Mohamed Fadhel Mrad, Riadh Gouider
No abstract text is available yet for this article.
December 2015: La Tunisie Médicale
Luigi Attademo, Francesco Bernardini, Roberto Quartesan
BACKGROUND: The term 'schizo-obsessive disorder' was coined to describe schizophrenia (SCZ) patients who are also affected by obsessive-compulsive symptoms (OCS) or also meet the criteria for obsessive-compulsive disorder (OCD). Several studies have investigated the clinical and epidemiological features of OCS/OCD in SCZ, but the neuroimaging literature is sparse. The aim of this brief report is to describe some of the most important neuroimaging findings regarding schizo-obsessive disorder...
2016: Psychopathology
Ismail M Youssef, Magda T Fahmy, Wafaa L Haggag, Khalid A Mohamed, Amany A Baalash
OBJECTIVE: To determine the frequency of suicidal thoughts and suicidal probability among poly-substance abusers in Saudi population, and to examine the relation between dual diagnosis and suicidal thoughts. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Al-Baha Psychiatric Hospital, Saudi Arabia, from May 2011 to June 2012. METHODOLOGY: Participants were 239 subjects, aged 18 - 45 years. We reviewed 122 individuals who fulfilled the DSM-IV-TR criteria of substance abuse for two or more substances, and their data were compared with that collected from 117 control persons...
February 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Eric Huang, Clement C Zai, Amanda Lisoway, Malgorzata Maciukiewicz, Daniel Felsky, Arun K Tiwari, Jeffrey R Bishop, Masashi Ikeda, Patricio Molero, Felipe Ortuno, Stefano Porcelli, Jerzy Samochowiec, Pawel Mierzejewski, Shugui Gao, Benedicto Crespo-Facorro, José M Pelayo-Terán, Harpreet Kaur, Ritushree Kukreti, Herbert Y Meltzer, Jeffrey A Lieberman, Steven G Potkin, Daniel J Müller, James L Kennedy
BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. Multiple studies have analyzed the COMT Val158Met variant in relation to antipsychotic response. Here, we conducted a meta-analysis examining the relationship between COMT Val158Met and antipsychotic response...
May 2016: International Journal of Neuropsychopharmacology
Monika Szkultecka-Dębek, Jacek Walczak, Joanna Augustyńska, Katarzyna Miernik, Jarosław Stelmachowski, Izabela Pieniążek, Grzegorz Obrzut, Angelika Pogroszewska, Gabrijela Paulić, Marić Damir, Siniša Antolić, Rok Tavčar, Andra Indrikson, Kaire Aadamsoo, Slobodan Jankovic, Attila J Pulay, József Rimay, Márton Varga, Ivana Sulkova, Petra Veržun
To gather and review data describing the epidemiology of schizophrenia and clinical guidelines for schizophrenia therapy in seven Central and Eastern European countries, with a focus on negative symptoms. Methods : A literature search was conducted which included publications from 1995 to 2012 that were indexed in key databases. Results : Reports of mean annual incidence of schizophrenia varied greatly, from 0.04 to 0.58 per 1,000 population. Lifetime prevalence varied from 0.4% to 1.4%. One study reported that at least one negative symptom was present in 57...
2015: Clinical Practice and Epidemiology in Mental Health: CP & EMH
Ying-Tzu Chang, Ling-Ling Lee
BACKGROUND: Schizophrenia is one of the most severe mental illnesses. Studies have found that 25% to 80% of all schizophrenic patients are non-compliant in medication-taking. Non-compliance of medication-taking is associated with higher readmission rates that result from relapses. Compliance therapy has been developed to modify negative beliefs toward medication and aims to improve drug attitude toward medication-taking. However, the effect of compliance therapy on drug attitude among schizophrenic patients is unclear...
2015: JBI Database of Systematic Reviews and Implementation Reports
Catherine Henderson, Martin Knapp, Ksenija Yeeles, Stephen Bremner, Sandra Eldridge, Anthony S David, Nicola O'Connell, Tom Burns, Stefan Priebe
BACKGROUND: Offering a modest financial incentive to people with psychosis can promote adherence to depot antipsychotic medication, but the cost-effectiveness of this approach has not been examined. METHODS: Economic evaluation within a pragmatic cluster-randomised controlled trial. 141 patients under the care of 73 teams (clusters) were randomised to intervention or control; 138 patients with diagnoses of schizophrenia, schizo-affective disorder or bipolar disorder participated...
2015: PloS One
B E Focseneanu, I Dobrescu, G Marian, V Rusanu
BACKGROUND: Given that the obsessive-compulsive disorder (OCD) occurs with a much higher frequency in schizophrenia than in the general population, and, both schizophrenia and OCD are presumed to be neurodevelopmental disorders, the hypothesis of a distinct subtype of schizophrenia, the "schizo-obsessive" one, was raised. AIM: Considering the neurological soft signs as neurobiological markers in schizophrenia, the aim of this study was to verify the hypothesis of the existence of this "schizo-obsessive" endophenotype of schizophrenia, by using the Neurological Evaluation Scale (NES) in patients with schizophrenia...
2015: Journal of Medicine and Life
A Taksal, P M Sudhir, Keshav Kumar Janakiprasad, Deepashree Viswanath, Jagadisha Thirthalli
Functional outcome is an important index of recovery in patients with Schizophrenia (SZ). Several factors impact social functioning, including neurocognition. The Integrated Psychological Therapy (IPT) has been effective in improving social-functioning in SZ patients, but needs to be evaluated for its feasibility and impact in the Indian subcontinent. The study examined the effectiveness of the IPT on neurocognition and social functioning in patients with SZ. An open label design with baseline, post-intervention and 3-month follow-up assessments was adopted...
October 2015: Asian Journal of Psychiatry
O Godin, M Leboyer, A Gaman, B Aouizerate, F Berna, L Brunel, D Capdevielle, I Chereau, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, Y Le Strat, P M Llorca, D Misdrahi, R Rey, R Richieri, C Passerieux, A Schandrin, F Schürhoff, M Urbach, P Vidalhet, N Girerd, G Fond
OBJECTIVE: Abdominal obesity was suggested to be a better predictor than Metabolic Syndrome (MetS) for cardiovascular mortality, however this is has not been extensively studied in schizophrenia. Hyperuricemia (HU) was also suggested to be both an independent risk factor for greater somatic comorbidity and a global metabolic stress marker in patients with schizophrenia. The aim of this study was to estimate the prevalence of MetS, abdominal obesity and HU, to examine the association between metabolic parameters with HU in a cohort of French patients with schizophrenia or schizo-affective disorder (SZ), and to estimate the prevalence rates of treatment of cardio-vascular risk factors...
October 2015: Schizophrenia Research
Adrienne Cheung, Julian M Somers, Akm Moniruzzaman, Michelle Patterson, Charles J Frankish, Michael Krausz, Anita Palepu
BACKGROUND: Homelessness, substance use, and mental disorders each have been associated with higher rates of emergency department (ED) use and hospitalization. We sought to understand the correlation between ED use, hospital admission, and substance dependence among homeless individuals with concurrent mental illness who participated in a 'Housing First' (HF) intervention trial. METHODS: The Vancouver At Home study consisted of two randomized controlled trials addressing homeless individuals with mental disorders who have "high" or "moderate" levels of need...
August 5, 2015: Addiction Science & Clinical Practice
Flavie Waters, Vivian W Chiu, Aleksandar Janca, Amanda Atkinson, Melissa Ree
Symptoms of psychosis such as hallucinations and delusions can be intrusive and unwanted and often remain treatment-resistant. Due to recent progress in basic and clinical sciences, novel approaches such as sleep-based interventions are increasingly becoming offered to address the physical and mental health issues of people with severe mental illness. While the primary outcome is to improve sleep, studies have demonstrated that interventions that target symptoms of insomnia can also produce improvements in the severity of psychotic symptoms, quality of life, and functional outcomes...
2015: Frontiers in Psychology
Sonika Batra, Ravi Bhushan
Bupropion, a tricyclic aminoketone, is used primarily in the treatment of depression, the management of patients with bipolar and schizo-affective disorder, and the treatment of Parkinson's disease. Bupropion is marketed as a racemate, but the racemic mixture is known to have several disadvantages while the two isomers of bupropion and its metabolite differ significantly in their pharmacological activities. Therefore, the stereoselective determination of the drug enantiomers in pharamaceutical dosages, plasma or urine is of potential clinical and analytical importance...
May 2016: Biomedical Chromatography: BMC
F Schürhoff, G Fond, F Berna, E Bulzacka, J Vilain, D Capdevielle, D Misdrahi, M Leboyer, P-M Llorca
Schizophrenia is probably the most severe psychiatric disorder with much suffering for the patients and huge costs for the society. Efforts to provide optimal care by general practitioners and psychiatrists are undermined by the complexity of the disorder and difficulties in applying clinical practice guidelines and new research findings to the spectrum of cases seen in day-to-day practice. An innovative model of assessment aimed at improving global care of people with schizophrenia provided by the French national network of schizophrenia expert centres is being described...
September 2015: European Psychiatry: the Journal of the Association of European Psychiatrists
Craig Steel, Mark van der Gaag, Kees Korrelboom, Judit Simon, Peter Phiri, M Fazil Baksh, Til Wykes, Diana Rose, Suzanna Rose, Mark Hardcastle, Simon Enright, Gareth Evans, David Kingdon
BACKGROUND: Depression is highly prevalent within individuals diagnosed with schizophrenia, and is associated with an increased risk of suicide. There are no current evidence based treatments for low mood within this group. The specific targeting of co-morbid conditions within complex mental health problems lends itself to the development of short-term structured interventions which are relatively easy to disseminate within health services. A brief cognitive intervention based on a competitive memory theory of depression, is being evaluated in terms of its effectiveness in reducing depression within this group...
April 14, 2015: BMC Psychiatry
Luca Pingani, Sara Evans-Lacko, Valeria Del Vecchio, Mario Luciano, Sara Catellani, Arneda Hamati, Marco Rigatelli, Andrea Fiorillo
Stigma associated with mental disorders represents one main obstacle to receive appropriate care for people with mental disorders. Compared to adults, university students have higher levels of stigmatizing attitudes toward patients with schizophrenia. The primary aim of this case-control study was to assess university students' ability to identify stigma toward schizophrenia in Italian newspapers. Secondary aims were: a) to explore differences in stigmatizing attitudes among two different groups of university students (health professionals [HP] and nonhealth professionals [n-HP]) and b) to compare the attitudes of these two groups with those of a sample of expert psychiatrists...
March 2015: American Journal of Orthopsychiatry
Kirsten Catthoor, Didier Schrijvers, Joost Hutsebaut, Dineke Feenstra, Philippe Persoons, Marc De Hert, Jozef Peuskens, Bernard Sabbe
AIM: To assess presence and severity of associative stigma in family members of psychotic patients and factors for higher associative stigma. METHODS: Standardized semi-structured interview of 150 family members of psychotic patients receiving full time treatment. This study on associative stigma in family members of psychotic patients was part of a larger research program on the burden of the family, using "Interview for the Burden of the Family" and the chapters stigma, treatment and attribution from the "Family interview Schedule"...
March 22, 2015: World Journal of Psychiatry
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