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https://www.readbyqxmd.com/read/29125018/the-glasgow-antipsychotic-side-effects-scale-for-clozapine-in-inpatients-and-outpatients-with-schizophrenia-or-schizoaffective-disorder
#1
Dragana Ignjatović Ristić, Dan Cohen, Andrea Obradović, Katarina Nikić-Đuričić, Marija Drašković, Darko Hinić
BACKGROUND: The inconsistency in clinician and patient ratings of clozapine-induced side effects underscore the need to supplement clinician-based estimates of side effects with patient-reported ones. AIMS: The main aims of the study are validation of the Glasgow antipsychotic side-effects scale for clozapine (GASS-C) in Serbian inpatients/outpatients with schizophrenia or schizo-affective disorder and recommendations for its future use, based on common and rare clozapine-associated side-effects...
November 10, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29061423/neuropsychological-profile-of-schizophrenia-with-and-without-obsessive-compulsive-disorder
#2
Firoz Kazhungil, Keshav J Kumar, Biju Viswanath, Ravi Girikematha Shankar, Thennarasu Kandavel, Suresh Bada Math, Ganesan Venkatasubramanian, Y C J Reddy
Neuropsychological profile of schizophrenia with obsessive compulsive disorder (OCD) in comparison with that of schizophrenia without OCD is understudied and the results are inconsistent. We hypothesize that patients having schizophrenia with OCD ('schizo-obsessive disorder') may have unique neuropsychological deficits in comparison with those with schizophrenia alone, particularly with respect to executive functions. Thirty patients with schizo-obsessive disorder and 30 individually matched patients with schizophrenia without any obsessive-compulsive symptoms formed the sample of the study...
October 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28877269/pf16-and-phipmw-expanding-the-realm-of-pseudomonas-putida-bacteriophages
#3
Damian J Magill, Victor N Krylov, Olga V Shaburova, John W McGrath, Christopher C R Allen, John P Quinn, Leonid A Kulakov
We present the analysis of two novel Pseudomonas putida phages, pf16 and phiPMW. Pf16 represents a peripherally related T4-like phage, and is the first of its kind infecting a Pseudomonad, with evidence suggesting cyanophage origins. Extensive divergence has resulted in pf16 occupying a newly defined clade designated as the pf16-related phages, lying at the interface of the Schizo T-Evens and Exo T-Evens. Recombination with an ancestor of the P. putida phage AF is likely responsible for the tropism of this phage...
2017: PloS One
https://www.readbyqxmd.com/read/28805246/associations-between-belief-inflexibility-and-dimensions-of-delusions-a-meta-analytic-review-of-two-approaches-to-assessing-belief-flexibility
#4
Chen Zhu, Xiaoqi Sun, Suzanne Ho-Wai So
OBJECTIVES: Belief inflexibility has been suggested to maintain delusions. Different measures of assessing belief inflexibility have been developed, and it remains unclear whether patients with delusions display belief inflexibility similarly across measures. As delusions consist of multiple dimensions, the aim of this meta-analytic review was to examine how belief inflexibility is related to different aspects of delusions (conviction, distress, and preoccupation) and to compare these associations between interview-based and task-based measures of belief inflexibility...
August 14, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28633054/men-and-women-with-psychosis-and-the-impact-of-illness-duration-on-sex-differences-the-second-australian-national-survey-of-psychosis
#5
Mary-Claire Hanlon, Linda E Campbell, Natalie Single, Clare Coleman, Vera A Morgan, Susan M Cotton, Helen J Stain, David J Castle
We aimed to examine and compare sex-differences in people receiving treatment for psychotic illnesses in community settings, based on long or short duration of illness; expecting association between longer illness-duration and worse outcomes in women and men. Clinical, demographic and service-use data from the Survey of High Impact Psychosis were analysed by sex and duration of illness (≤5 years; ≥6 years), using independent t-tests, chi-square tests, one-way ANOVA, and Cramer's V. Of the 1825 participants, 47% had schizophrenia, 17...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28498576/a-critique-of-the-ultra-high-risk-and-transition-paradigm
#6
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/27669819/schizo-obsessive-spectrum-disorders-an-update
#7
REVIEW
Estêvão Scotti-Muzzi, Osvaldo Luis Saide
The presence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorders (OCD) in schizophrenia is frequent, and a new clinical entity has been proposed for those who show the dual diagnosis: the schizo-obsessive disorder. This review scrutinizes the literature across the main academic databases, and provides an update on different aspects of schizo-obsessive spectrum disorders, which include schizophrenia, schizotypal personality disorder (SPD) with OCD, OCD with poor insight, schizophrenia with OCS, and schizophrenia with OCD (schizo-obsessive disorder)...
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/27612527/cannabis-and-development-of-dual-diagnoses-a-literature-review
#8
Rebecca C Hanna, Jessica M Perez, Subroto Ghose
BACKGROUND: The use of cannabis has garnered more attention recently with ongoing efforts at marijuana legalization. The consequences of cannabis use are not clearly understood and remain a concern. OBJECTIVES: To review the acute and persistent effects of cannabis use and associations with psychiatric disorders. METHODS: Using Pubmed and PsychInfo, we conducted a narrative review of the literature on cannabis and psychiatric comorbidity using the keywords cannab*, marijuana, schizo*, psychosis, mood, depression, mania, bipolar, and anxiety...
July 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27336055/schizophrenia-interactome-with-504-novel-protein-protein-interactions
#9
Madhavi K Ganapathiraju, Mohamed Thahir, Adam Handen, Saumendra N Sarkar, Robert A Sweet, Vishwajit L Nimgaonkar, Christine E Loscher, Eileen M Bauer, Srilakshmi Chaparala
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein interactions (PPIs) are unknown for many of the liability genes. We developed a computational model to discover PPIs, which is found to be highly accurate according to computational evaluations and experimental validations of selected PPIs...
2016: NPJ Schizophrenia
https://www.readbyqxmd.com/read/27249395/fahr-s-disease-revealed-by-psychiatric-symptoms-like-schizo-affective-disorder
#10
Asma Ben Houidi, Faten Ellouze, Mona Ben Djebara, Youssef Sidhom, Mohamed Fadhel Mrad, Riadh Gouider
No abstract text is available yet for this article.
December 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/26905419/schizo-obsessive-disorder-a-brief-report-of-neuroimaging-findings
#11
REVIEW
Luigi Attademo, Francesco Bernardini, Roberto Quartesan
BACKGROUND: The term 'schizo-obsessive disorder' was coined to describe schizophrenia (SCZ) patients who are also affected by obsessive-compulsive symptoms (OCS) or also meet the criteria for obsessive-compulsive disorder (OCD). Several studies have investigated the clinical and epidemiological features of OCS/OCD in SCZ, but the neuroimaging literature is sparse. The aim of this brief report is to describe some of the most important neuroimaging findings regarding schizo-obsessive disorder...
2016: Psychopathology
https://www.readbyqxmd.com/read/26876401/dual-diagnosis-and-suicide-probability-in-poly-drug-users
#12
Ismail M Youssef, Magda T Fahmy, Wafaa L Haggag, Khalid A Mohamed, Amany A Baalash
OBJECTIVE: To determine the frequency of suicidal thoughts and suicidal probability among poly-substance abusers in Saudi population, and to examine the relation between dual diagnosis and suicidal thoughts. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Al-Baha Psychiatric Hospital, Saudi Arabia, from May 2011 to June 2012. METHODOLOGY: Participants were 239 subjects, aged 18 - 45 years. We reviewed 122 individuals who fulfilled the DSM-IV-TR criteria of substance abuse for two or more substances, and their data were compared with that collected from 117 control persons...
February 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/26745992/catechol-o-methyltransferase-val158met-polymorphism-and-clinical-response-to-antipsychotic-treatment-in-schizophrenia-and-schizo-affective-disorder-patients-a-meta-analysis
#13
Eric Huang, Clement C Zai, Amanda Lisoway, Malgorzata Maciukiewicz, Daniel Felsky, Arun K Tiwari, Jeffrey R Bishop, Masashi Ikeda, Patricio Molero, Felipe Ortuno, Stefano Porcelli, Jerzy Samochowiec, Pawel Mierzejewski, Shugui Gao, Benedicto Crespo-Facorro, José M Pelayo-Terán, Harpreet Kaur, Ritushree Kukreti, Herbert Y Meltzer, Jeffrey A Lieberman, Steven G Potkin, Daniel J Müller, James L Kennedy
BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. Multiple studies have analyzed the COMT Val158Met variant in relation to antipsychotic response. Here, we conducted a meta-analysis examining the relationship between COMT Val158Met and antipsychotic response...
May 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26535049/epidemiology-and-treatment-guidelines-of-negative-symptoms-in-schizo-phrenia-in-central-and-eastern-europe-a-literature-review
#14
Monika Szkultecka-Dębek, Jacek Walczak, Joanna Augustyńska, Katarzyna Miernik, Jarosław Stelmachowski, Izabela Pieniążek, Grzegorz Obrzut, Angelika Pogroszewska, Gabrijela Paulić, Marić Damir, Siniša Antolić, Rok Tavčar, Andra Indrikson, Kaire Aadamsoo, Slobodan Jankovic, Attila J Pulay, József Rimay, Márton Varga, Ivana Sulkova, Petra Veržun
To gather and review data describing the epidemiology of schizophrenia and clinical guidelines for schizophrenia therapy in seven Central and Eastern European countries, with a focus on negative symptoms. Methods : A literature search was conducted which included publications from 1995 to 2012 that were indexed in key databases. Results : Reports of mean annual incidence of schizophrenia varied greatly, from 0.04 to 0.58 per 1,000 population. Lifetime prevalence varied from 0.4% to 1.4%. One study reported that at least one negative symptom was present in 57...
2015: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/26455856/the-effectiveness-of-compliance-therapy-on-drug-attitude-among-schizophrenic-patients-a-systematic-review
#15
REVIEW
Ying-Tzu Chang, Ling-Ling Lee
BACKGROUND: Schizophrenia is one of the most severe mental illnesses. Studies have found that 25% to 80% of all schizophrenic patients are non-compliant in medication-taking. Non-compliance of medication-taking is associated with higher readmission rates that result from relapses. Compliance therapy has been developed to modify negative beliefs toward medication and aims to improve drug attitude toward medication-taking. However, the effect of compliance therapy on drug attitude among schizophrenic patients is unclear...
2015: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/26448540/cost-effectiveness-of-financial-incentives-to-promote-adherence-to-depot-antipsychotic-medication-economic-evaluation-of-a-cluster-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Catherine Henderson, Martin Knapp, Ksenija Yeeles, Stephen Bremner, Sandra Eldridge, Anthony S David, Nicola O'Connell, Tom Burns, Stefan Priebe
BACKGROUND: Offering a modest financial incentive to people with psychosis can promote adherence to depot antipsychotic medication, but the cost-effectiveness of this approach has not been examined. METHODS: Economic evaluation within a pragmatic cluster-randomised controlled trial. 141 patients under the care of 73 teams (clusters) were randomised to intervention or control; 138 patients with diagnoses of schizophrenia, schizo-affective disorder or bipolar disorder participated...
2015: PloS One
https://www.readbyqxmd.com/read/26361516/neurological-soft-signs-in-early-stage-of-schizophrenia-associated-with-obsessive-compulsive-disorder
#17
B E Focseneanu, I Dobrescu, G Marian, V Rusanu
BACKGROUND: Given that the obsessive-compulsive disorder (OCD) occurs with a much higher frequency in schizophrenia than in the general population, and, both schizophrenia and OCD are presumed to be neurodevelopmental disorders, the hypothesis of a distinct subtype of schizophrenia, the "schizo-obsessive" one, was raised. AIM: Considering the neurological soft signs as neurobiological markers in schizophrenia, the aim of this study was to verify the hypothesis of the existence of this "schizo-obsessive" endophenotype of schizophrenia, by using the Neurological Evaluation Scale (NES) in patients with schizophrenia...
2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/26277224/feasibility-and-effectiveness-of-the-integrated-psychological-therapy-ipt-in-patients-with-schizophrenia-a-preliminary-investigation-from-india
#18
A Taksal, P M Sudhir, Keshav Kumar Janakiprasad, Deepashree Viswanath, Jagadisha Thirthalli
Functional outcome is an important index of recovery in patients with Schizophrenia (SZ). Several factors impact social functioning, including neurocognition. The Integrated Psychological Therapy (IPT) has been effective in improving social-functioning in SZ patients, but needs to be evaluated for its feasibility and impact in the Indian subcontinent. The study examined the effectiveness of the IPT on neurocognition and social functioning in patients with SZ. An open label design with baseline, post-intervention and 3-month follow-up assessments was adopted...
October 2015: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/26255568/metabolic-syndrome-abdominal-obesity-and-hyperuricemia-in-schizophrenia-results-from-the-face-sz-cohort
#19
MULTICENTER STUDY
O Godin, M Leboyer, A Gaman, B Aouizerate, F Berna, L Brunel, D Capdevielle, I Chereau, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, Y Le Strat, P M Llorca, D Misdrahi, R Rey, R Richieri, C Passerieux, A Schandrin, F Schürhoff, M Urbach, P Vidalhet, N Girerd, G Fond
OBJECTIVE: Abdominal obesity was suggested to be a better predictor than Metabolic Syndrome (MetS) for cardiovascular mortality, however this is has not been extensively studied in schizophrenia. Hyperuricemia (HU) was also suggested to be both an independent risk factor for greater somatic comorbidity and a global metabolic stress marker in patients with schizophrenia. The aim of this study was to estimate the prevalence of MetS, abdominal obesity and HU, to examine the association between metabolic parameters with HU in a cohort of French patients with schizophrenia or schizo-affective disorder (SZ), and to estimate the prevalence rates of treatment of cardio-vascular risk factors...
October 2015: Schizophrenia Research
https://www.readbyqxmd.com/read/26242968/emergency-department-use-and-hospitalizations-among-homeless-adults-with-substance-dependence-and-mental-disorders
#20
Adrienne Cheung, Julian M Somers, Akm Moniruzzaman, Michelle Patterson, Charles J Frankish, Michael Krausz, Anita Palepu
BACKGROUND: Homelessness, substance use, and mental disorders each have been associated with higher rates of emergency department (ED) use and hospitalization. We sought to understand the correlation between ED use, hospital admission, and substance dependence among homeless individuals with concurrent mental illness who participated in a 'Housing First' (HF) intervention trial. METHODS: The Vancouver At Home study consisted of two randomized controlled trials addressing homeless individuals with mental disorders who have "high" or "moderate" levels of need...
August 5, 2015: Addiction Science & Clinical Practice
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