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F Scheffler, S Kilian, B Chiliza, L Asmal, L Phahladira, S du Plessis, M Kidd, R M Murray, M Di Forti, S Seedat, R Emsley
While acute cannabis use stimulates appetite, general population studies suggest that chronic use is associated with reduced risk of obesity and other cardiometabolic risk factors. In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12 months...
March 6, 2018: Schizophrenia Research
G Brun, H Verdoux, G Couhet, C Quiles
OBJECTIVES: Video games and virtual reality have recently become used by clinicians for training or information media or as therapeutic tools. The purpose is to review the use of these technologies for therapy destined for schizophrenia patients. METHODS: We conducted a review in October 2016 using Pubmed, Scopus and PsychInfo using the following Medical Subject Headings (MESH): "video games", "virtual reality" and "therapy, computer-assisted/methods", each associated with "schizophrenia"...
February 28, 2018: L'Encéphale
S Buoro, B Manenti, M Seghezzi, V Moioli, M Bagorria, A Callegaro, C Ottomano, G Lippi
INTRODUCTION: Malaria is a life-threatening infectious disease, which has been for long confined to specific endemic areas. Nevertheless, the recent increase in immigration flows from endemic regions and imported cases has reemphasized many diagnostic challenges in Western countries, thus paving the way to introduce rapid and accurate strategies for screening subjects with suspected Malaria infection. Therefore, the aim of this article was to describe our recent experience with Sysmex XN-module for rapid screening of subjects with suspected Malaria...
February 21, 2018: International Journal of Laboratory Hematology
Yong-Ming Wang, Lai-Quan Zou, Wen-Lan Xie, Zhuo-Ya Yang, Xiong-Zhao Zhu, Eric F C Cheung, Thomas Alrik Sørensen, Arne Møller, Raymond C K Chan
Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups...
January 20, 2018: Schizophrenia Bulletin
Dragana Ignjatović Ristić, Dan Cohen, Andrea Obradović, Katarina Nikić-Đuričić, Marija Drašković, Darko Hinić
BACKGROUND: The inconsistency in clinician and patient ratings of clozapine-induced side effects underscore the need to supplement clinician-based estimates of side effects with patient-reported ones. AIMS: The main aims of the study are validation of the Glasgow antipsychotic side-effects scale for clozapine (GASS-C) in Serbian inpatients/outpatients with schizophrenia or schizo-affective disorder and recommendations for its future use, based on common and rare clozapine-associated side-effects...
February 2018: Nordic Journal of Psychiatry
Firoz Kazhungil, Keshav J Kumar, Biju Viswanath, Ravi Girikematha Shankar, Thennarasu Kandavel, Suresh Bada Math, Ganesan Venkatasubramanian, Y C J Reddy
Neuropsychological profile of schizophrenia with obsessive compulsive disorder (OCD) in comparison with that of schizophrenia without OCD is understudied and the results are inconsistent. We hypothesize that patients having schizophrenia with OCD ('schizo-obsessive disorder') may have unique neuropsychological deficits in comparison with those with schizophrenia alone, particularly with respect to executive functions. Thirty patients with schizo-obsessive disorder and 30 individually matched patients with schizophrenia without any obsessive-compulsive symptoms formed the sample of the study...
October 2017: Asian Journal of Psychiatry
Damian J Magill, Victor N Krylov, Olga V Shaburova, John W McGrath, Christopher C R Allen, John P Quinn, Leonid A Kulakov
We present the analysis of two novel Pseudomonas putida phages, pf16 and phiPMW. Pf16 represents a peripherally related T4-like phage, and is the first of its kind infecting a Pseudomonad, with evidence suggesting cyanophage origins. Extensive divergence has resulted in pf16 occupying a newly defined clade designated as the pf16-related phages, lying at the interface of the Schizo T-Evens and Exo T-Evens. Recombination with an ancestor of the P. putida phage AF is likely responsible for the tropism of this phage...
2017: PloS One
Chen Zhu, Xiaoqi Sun, Suzanne Ho-Wai So
OBJECTIVES: Belief inflexibility has been suggested to maintain delusions. Different measures of assessing belief inflexibility have been developed, and it remains unclear whether patients with delusions display belief inflexibility similarly across measures. As delusions consist of multiple dimensions, the aim of this meta-analytic review was to examine how belief inflexibility is related to different aspects of delusions (conviction, distress, and preoccupation) and to compare these associations between interview-based and task-based measures of belief inflexibility...
August 14, 2017: British Journal of Clinical Psychology
Mary-Claire Hanlon, Linda E Campbell, Natalie Single, Clare Coleman, Vera A Morgan, Susan M Cotton, Helen J Stain, David J Castle
We aimed to examine and compare sex-differences in people receiving treatment for psychotic illnesses in community settings, based on long or short duration of illness; expecting association between longer illness-duration and worse outcomes in women and men. Clinical, demographic and service-use data from the Survey of High Impact Psychosis were analysed by sex and duration of illness (≤5 years; ≥6 years), using independent t-tests, chi-square tests, one-way ANOVA, and Cramer's V. Of the 1825 participants, 47% had schizophrenia, 17...
June 13, 2017: Psychiatry Research
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Estêvão Scotti-Muzzi, Osvaldo Luis Saide
The presence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorders (OCD) in schizophrenia is frequent, and a new clinical entity has been proposed for those who show the dual diagnosis: the schizo-obsessive disorder. This review scrutinizes the literature across the main academic databases, and provides an update on different aspects of schizo-obsessive spectrum disorders, which include schizophrenia, schizotypal personality disorder (SPD) with OCD, OCD with poor insight, schizophrenia with OCS, and schizophrenia with OCD (schizo-obsessive disorder)...
June 2017: CNS Spectrums
Rebecca C Hanna, Jessica M Perez, Subroto Ghose
BACKGROUND: The use of cannabis has garnered more attention recently with ongoing efforts at marijuana legalization. The consequences of cannabis use are not clearly understood and remain a concern. OBJECTIVES: To review the acute and persistent effects of cannabis use and associations with psychiatric disorders. METHODS: Using Pubmed and PsychInfo, we conducted a narrative review of the literature on cannabis and psychiatric comorbidity using the keywords cannab*, marijuana, schizo*, psychosis, mood, depression, mania, bipolar, and anxiety...
July 2017: American Journal of Drug and Alcohol Abuse
Madhavi K Ganapathiraju, Mohamed Thahir, Adam Handen, Saumendra N Sarkar, Robert A Sweet, Vishwajit L Nimgaonkar, Christine E Loscher, Eileen M Bauer, Srilakshmi Chaparala
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein interactions (PPIs) are unknown for many of the liability genes. We developed a computational model to discover PPIs, which is found to be highly accurate according to computational evaluations and experimental validations of selected PPIs...
2016: NPJ Schizophrenia
Asma Ben Houidi, Faten Ellouze, Mona Ben Djebara, Youssef Sidhom, Mohamed Fadhel Mrad, Riadh Gouider
No abstract text is available yet for this article.
December 2015: La Tunisie Médicale
Luigi Attademo, Francesco Bernardini, Roberto Quartesan
BACKGROUND: The term 'schizo-obsessive disorder' was coined to describe schizophrenia (SCZ) patients who are also affected by obsessive-compulsive symptoms (OCS) or also meet the criteria for obsessive-compulsive disorder (OCD). Several studies have investigated the clinical and epidemiological features of OCS/OCD in SCZ, but the neuroimaging literature is sparse. The aim of this brief report is to describe some of the most important neuroimaging findings regarding schizo-obsessive disorder...
2016: Psychopathology
Ismail M Youssef, Magda T Fahmy, Wafaa L Haggag, Khalid A Mohamed, Amany A Baalash
OBJECTIVE: To determine the frequency of suicidal thoughts and suicidal probability among poly-substance abusers in Saudi population, and to examine the relation between dual diagnosis and suicidal thoughts. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Al-Baha Psychiatric Hospital, Saudi Arabia, from May 2011 to June 2012. METHODOLOGY: Participants were 239 subjects, aged 18 - 45 years. We reviewed 122 individuals who fulfilled the DSM-IV-TR criteria of substance abuse for two or more substances, and their data were compared with that collected from 117 control persons...
February 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Eric Huang, Clement C Zai, Amanda Lisoway, Malgorzata Maciukiewicz, Daniel Felsky, Arun K Tiwari, Jeffrey R Bishop, Masashi Ikeda, Patricio Molero, Felipe Ortuno, Stefano Porcelli, Jerzy Samochowiec, Pawel Mierzejewski, Shugui Gao, Benedicto Crespo-Facorro, José M Pelayo-Terán, Harpreet Kaur, Ritushree Kukreti, Herbert Y Meltzer, Jeffrey A Lieberman, Steven G Potkin, Daniel J Müller, James L Kennedy
BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. Multiple studies have analyzed the COMT Val158Met variant in relation to antipsychotic response. Here, we conducted a meta-analysis examining the relationship between COMT Val158Met and antipsychotic response...
May 2016: International Journal of Neuropsychopharmacology
Monika Szkultecka-Dębek, Jacek Walczak, Joanna Augustyńska, Katarzyna Miernik, Jarosław Stelmachowski, Izabela Pieniążek, Grzegorz Obrzut, Angelika Pogroszewska, Gabrijela Paulić, Marić Damir, Siniša Antolić, Rok Tavčar, Andra Indrikson, Kaire Aadamsoo, Slobodan Jankovic, Attila J Pulay, József Rimay, Márton Varga, Ivana Sulkova, Petra Veržun
To gather and review data describing the epidemiology of schizophrenia and clinical guidelines for schizophrenia therapy in seven Central and Eastern European countries, with a focus on negative symptoms. Methods : A literature search was conducted which included publications from 1995 to 2012 that were indexed in key databases. Results : Reports of mean annual incidence of schizophrenia varied greatly, from 0.04 to 0.58 per 1,000 population. Lifetime prevalence varied from 0.4% to 1.4%. One study reported that at least one negative symptom was present in 57...
2015: Clinical Practice and Epidemiology in Mental Health: CP & EMH
Ying-Tzu Chang, Ling-Ling Lee
BACKGROUND: Schizophrenia is one of the most severe mental illnesses. Studies have found that 25% to 80% of all schizophrenic patients are non-compliant in medication-taking. Non-compliance of medication-taking is associated with higher readmission rates that result from relapses. Compliance therapy has been developed to modify negative beliefs toward medication and aims to improve drug attitude toward medication-taking. However, the effect of compliance therapy on drug attitude among schizophrenic patients is unclear...
2015: JBI Database of Systematic Reviews and Implementation Reports
Catherine Henderson, Martin Knapp, Ksenija Yeeles, Stephen Bremner, Sandra Eldridge, Anthony S David, Nicola O'Connell, Tom Burns, Stefan Priebe
BACKGROUND: Offering a modest financial incentive to people with psychosis can promote adherence to depot antipsychotic medication, but the cost-effectiveness of this approach has not been examined. METHODS: Economic evaluation within a pragmatic cluster-randomised controlled trial. 141 patients under the care of 73 teams (clusters) were randomised to intervention or control; 138 patients with diagnoses of schizophrenia, schizo-affective disorder or bipolar disorder participated...
2015: PloS One
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