keyword
MENU ▼
Read by QxMD icon Read
search

gwas acei

keyword
https://www.readbyqxmd.com/read/29615742/systemic-and-specific-effects-of-antihypertensive-and-lipid-lowering-medication-on-plasma-protein-biomarkers-for-cardiovascular-diseases
#1
Stefan Enroth, Varun Maturi, Malin Berggrund, Sofia Bosdotter Enroth, Aristidis Moustakas, ├ůsa Johansson, Ulf Gyllensten
A large fraction of the adult population is on lifelong medication for cardiovascular disorders, but the metabolic consequences are largely unknown. This study determines the effects of common anti-hypertensive and lipid lowering drugs on circulating plasma protein biomarkers. We studied 425 proteins in plasma together with anthropometric and lifestyle variables, and the genetic profile in a cross-sectional cohort. We found 8406 covariate-protein associations, and a two-stage GWAS identified 17253 SNPs to be associated with 109 proteins...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28030426/meta-analysis-of-genome-wide-association-studies-on-the-intolerance-of-angiotensin-converting-enzyme-inhibitors
#2
Seyed H Mahmoudpour, Abirami Veluchamy, Moneeza K Siddiqui, Folkert W Asselbergs, Patrick C Souverein, Catherine E de Keyser, Albert Hofman, Chim C Lang, Alexander S F Doney, Bruno H Stricker, Anthonius de Boer, Anke H Maitland-van der Zee, Colin N A Palmer
OBJECTIVES: To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. METHODS: Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients who switched from an ACE-inhibitor to an angiotensin receptor blocker and controls were individuals who used ACE-inhibitors continuously for at least 2 years and did not switch...
March 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/26169577/a-genome-wide-association-study-identifies-variants-in-kcnip4-associated-with-ace-inhibitor-induced-cough
#3
J D Mosley, C M Shaffer, S L Van Driest, P E Weeke, Q S Wells, J H Karnes, D R Velez Edwards, W-Q Wei, P L Teixeira, L Bastarache, D C Crawford, R Li, T A Manolio, E P Bottinger, C A McCarty, J G Linneman, M H Brilliant, J A Pacheco, W Thompson, R L Chisholm, G P Jarvik, D R Crosslin, D S Carrell, E Baldwin, J Ralston, E B Larson, J Grafton, A Scrol, H Jouni, I J Kullo, G Tromp, K M Borthwick, H Kuivaniemi, D J Carey, M D Ritchie, Y Bradford, S S Verma, C G Chute, A Veluchamy, M K Siddiqui, C N A Palmer, A Doney, S H MahmoudPour, A H Maitland-van der Zee, A D Morris, J C Denny, D M Roden
The most common side effect of angiotensin-converting enzyme inhibitor (ACEi) drugs is cough. We conducted a genome-wide association study (GWAS) of ACEi-induced cough among 7080 subjects of diverse ancestries in the Electronic Medical Records and Genomics (eMERGE) network. Cases were subjects diagnosed with ACEi-induced cough. Controls were subjects with at least 6 months of ACEi use and no cough. A GWAS (1595 cases and 5485 controls) identified associations on chromosome 4 in an intron of KCNIP4. The strongest association was at rs145489027 (minor allele frequency=0...
June 2016: Pharmacogenomics Journal
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"