Bronagh Blackwood, Lyvonne N Tume, Kevin P Morris, Mike Clarke, Clíona McDowell, Karla Hemming, Mark J Peters, Lisa McIlmurray, Joanne Jordan, Ashley Agus, Margaret Murray, Roger Parslow, Timothy S Walsh, Duncan Macrae, Christina Easter, Richard G Feltbower, Daniel F McAuley
IMPORTANCE: There is limited evidence on the optimal strategy for liberating infants and children from invasive mechanical ventilation in the pediatric intensive care unit. OBJECTIVE: To determine if a sedation and ventilator liberation protocol intervention reduces the duration of invasive mechanical ventilation in infants and children anticipated to require prolonged mechanical ventilation. DESIGN, SETTING, AND PARTICIPANTS: A pragmatic multicenter, stepped-wedge, cluster randomized clinical trial was conducted that included 17 hospital sites (18 pediatric intensive care units) in the UK sequentially randomized from usual care to the protocol intervention...
August 3, 2021: JAMA