Philine Marchetta, Konrad Dapper, Morgan Hess, Dila Calis, Wibke Singer, Jakob Wertz, Stefan Fink, Steffen R Hage, Mesbah Alam, Kerstin Schwabe, Robert Lukowski, Jerome Bourien, Jean-Luc Puel, Michele H Jacob, Matthias H J Munk, Rüdiger Land, Lukas Rüttiger, Marlies Knipper
Autism spectrum disorder is discussed in the context of altered neural oscillations and imbalanced cortical excitation-inhibition of cortical origin. We studied here whether developmental changes in peripheral auditory processing, while preserving basic hearing function, lead to altered cortical oscillations. Local field potentials (LFPs) were recorded from auditory, visual, and prefrontal cortices and the hippocampus of BdnfPax2 KO mice. These mice develop an autism-like behavioral phenotype through deletion of BDNF in Pax2+ interneuron precursors, affecting lower brainstem functions, but not frontal brain regions directly...
January 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology