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https://www.readbyqxmd.com/read/28229169/electrophysiological-evidence-for-enhanced-attentional-deployment-in-spatial-learners
#1
Brandi Lee Drisdelle, Kyoko Konishi, Moussa Diarra, Veronique D Bohbot, Pierre Jolicoeur, Greg L West
Visual spatial attention is important during navigation processes that rely on a cognitive map, because spatial relationships between environmental landmarks need to be selected, encoded, and learned. People who navigate using this strategy are spatial learners, and this process relies on the hippocampus. Conversely, response learners memorize a series of actions to navigate, which relies on the caudate nucleus. Response learning, which is more efficient, is thought to involve less demanding cognitive operations, and is related to reduced grey matter in the hippocampus...
February 22, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28229040/predicting-primary-progressive-aphasias-with-support-vector-machine-approaches-in-structural-mri-data
#2
Sandrine Bisenius, Karsten Mueller, Janine Diehl-Schmid, Klaus Fassbender, Timo Grimmer, Frank Jessen, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Albert Ludolph, Anja Schneider, Sarah Anderl-Straub, Katharina Stuke, Adrian Danek, Markus Otto, Matthias L Schroeter
Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging data for early individual diagnosis, we used support vector machine classification on grey matter density maps obtained by voxel-based morphometry analysis to discriminate PPA subtypes (44 patients: 16 nonfluent/agrammatic variant PPA, 17 semantic variant PPA, 11 logopenic variant PPA) from 20 healthy controls (matched for sample size, age, and gender) in the cohort of the multi-center study of the German consortium for frontotemporal lobar degeneration...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28227482/assessing-app-quality-through-expert-peer-review-a-case-study-from-the-gray-matters-study
#3
Phillip J Hartin, Ian Cleland, Chris D Nugent, Sally I McClean, JoAnn Tschanz, Christine Clark, Maria C Norton, Phillip J Hartin, Ian Cleland, Chris D Nugent, Sally I McClean, JoAnn Tschanz, Christine Clark, Maria C Norton, JoAnn Tschanz, Christine Clark, Ian Cleland, Maria C Norton, Sally I McClean, Chris D Nugent, Phillip J Hartin
Health apps focused on inciting behavior change are becoming increasingly popular. Nevertheless, many lack underlying evidence base, scientific credibility and have limited clinical effectiveness. It is therefore important that apps are well-informed, scientifically credible, peer reviewed and evidence based. This paper presents the use of the Mobile App Rating Scale (MARS) to assess the quality of the Grey Matters app, a cross platform app to deliver health education material and track behavior change across multi-domains with the aim of reducing the risk of developing Alzheimer's disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227179/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#4
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226856/evaluation-of-the-electric-field-in-the-brain-during-transcranial-direct-current-stimulation-a-sensitivity-analysis
#5
Laura Santos, Miguel Martinho, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Oscar Ripolles, Giulio Ruffini, Pedro C Miranda, Laura Santos, Miguel Martinho, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Oscar Ripolles, Giulio Ruffini, Pedro C Miranda, Laura Santos, Miguel Martinho, Cornelia Wenger, Ricardo Salvador, Oscar Ripolles, Giulio Ruffini, Sofia R Fernandes, Pedro C Miranda
The use of computational modeling studies accounts currently for the best approach to predict the electric field (E-field) distribution in transcranial direct current stimulation. As with any model, the values attributed to the physical properties, namely the electrical conductivity of the tissues, affect the predicted E-field distribution. A wide range of values for the conductivity of most tissues is reported in the literature. In this work, we used the finite element method to compute the E-field induced in a realistic human head model for two electrode montages targeting the left dorso-lateral prefrontal cortex (DLPFC)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226410/patient-specific-computational-modeling-of-cortical-spreading-depression-via-diffusion-tensor-imaging
#6
Julia M Kroos, Isabella Marinelli, Ibai Diez, Jesus M Cortes, Sebastiano Stramaglia, Luca Gerardo-Giorda
Cortical Spreading Depression (CSD), a depolarization wave originating in the visual cortex and traveling towards the frontal lobe, is commonly accepted as a correlate of migraine visual aura. As of today, little is known about the mechanisms that can trigger or stop such phenomenon. However, the complex and highly individual characteristics of the brain cortex suggest that the geometry might have a significant impact in supporting or contrasting the propagation of CSD. Accurate patient-specific computational models are fundamental to cope with the high variability in cortical geometries among individuals, but also with the conduction anisotropy induced in a given cortex by the complex neuronal organisation in the grey matter...
February 22, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28223098/cannabis-and-alcohol-use-and-the-developing-brain
#7
REVIEW
A D Meruelo, N Castro, C I Cota, S F Tapert
Sex hormones and white (and grey) matter in the limbic system, cortex and other brain regions undergo changes during adolescence. Some of these changes include ongoing white matter myelination and sexually dimorphic features in grey and white matter. Adolescence is also a period of vulnerability when many are first exposed to alcohol and cannabis, which appear to influence the developing brain. Neuropsychological studies have provided considerable understanding of the effects of alcohol and cannabis on the brain...
February 18, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28222766/increased-cortical-lesion-load-and-intrathecal-inflammation-is-associated-with-oligoclonal-bands-in-multiple-sclerosis-patients-a-combined-csf-and-mri-study
#8
Gabriele Farina, Roberta Magliozzi, Marco Pitteri, Richard Reynolds, Stefania Rossi, Alberto Gajofatto, Maria Donata Benedetti, Francesco Facchiano, Salvatore Monaco, Massimiliano Calabrese
BACKGROUND: Although IgG oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) are a frequent phenomenon in multiple sclerosis (MS) patients, their relationship with grey matter lesions, intrathecal/meningeal inflammation and clinical evolution has not been clarified yet. The aim of our study was to assess the relationship between the OCBs, the inflammatory/neurodegenerative CSF profile at diagnosis, the cortical lesion load and the clinical evolution after 10 years. METHODS: This is a 10-year observational, cross-sectional study based on a combined MRI, cognitive and CSF profiling of the examined patients...
February 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28221364/neuroprotection-after-a-first-episode-of-mania-a-randomized-controlled-maintenance-trial-comparing-the-effects-of-lithium-and-quetiapine-on-grey-and-white-matter-volume
#9
M Berk, O Dandash, R Daglas, S M Cotton, K Allott, A Fornito, C Suo, P Klauser, B Liberg, L Henry, C Macneil, M Hasty, P McGorry, Cs Pantelis, M Yücel
No abstract text is available yet for this article.
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28220654/longitudinal-study-examining-abnormal-white-matter-integrity-using-a-tract-specific-analysis-in-individuals-with-a-high-risk-for-psychosis
#10
Junichi Saito, Masaaki Hori, Takahiro Nemoto, Naoyuki Katagiri, Keigo Shimoji, Shinya Ito, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
AIM: Although volume reductions in the grey matter have been previously observed in individuals with an at-risk mental state (ARMS) for psychosis, the features of white matter integrity and their correlation with psychiatric symptoms remain unclear. METHODS: Forty-six ARMS subjects were examined using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images; the subjects were also evaluated using the Scale of Prodromal Symptoms at baseline and at 52 weeks...
February 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28220062/anatomical-and-molecular-properties-of-long-descending-propriospinal-neurons-in-mice
#11
Jamie R Flynn, Victoria L Conn, Kieran A Boyle, David I Hughes, Masahiko Watanabe, Tomoko Velasquez, Martyn D Goulding, Robert J Callister, Brett A Graham
Long descending propriospinal neurons (LDPNs) are interneurons that form direct connections between cervical and lumbar spinal circuits. LDPNs are involved in interlimb coordination and are important mediators of functional recovery after spinal cord injury (SCI). Much of what we know about LDPNs comes from a range of species, however, the increased use of transgenic mouse lines to better define neuronal populations calls for a more complete characterisation of LDPNs in mice. In this study, we examined the cell body location, inhibitory neurotransmitter phenotype, developmental provenance, morphology and synaptic inputs of mouse LDPNs throughout the cervical and upper thoracic spinal cord...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28220041/butyrate-restores-hfd-induced-adaptations-in-brain-function-and-metabolism-in-mid-adult-obese-mice
#12
I A C Arnoldussen, M Wiesmann, C E Pelgrim, E M Wielemaker, W van Duyvenvoorde, P A Santos, L Verschuren, B J F Keijser, A Heerschap, R Kleemann, P Y Wielinga, A J Kiliaan
OBJECTIVE: Midlife obesity affects cognition and increases risk of developing dementia. Recent data suggest that intake of the short chain fatty acid butyrate could improve memory function, and may protect against diet-induced obesity by reducing bodyweight and adiposity. SUBJECTS: We examined the impact of a high fat diet (HFD) followed by intervention with 5% (w/w) dietary butyrate, on metabolism, microbiota, brain function and structure in the low-density-lipoprotein receptor knockout (LDLr-/-) mouse model in mid- and late life...
February 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28219764/gabaa-receptor-expression-and-white-matter-disruption-in-intrauterine-growth-restricted-piglets
#13
Viskasari P Kalanjati, Julie A Wixey, Stephanie M Miller, Paul B Colditz, Stella T Bjorkman
Intrauterine growth restriction (IUGR) is one of the most common causes of perinatal mortality and morbidity. White matter and neuronal injury are major pathophysiological features of the IUGR neonatal brain. GABAA (γ-aminobutyric acid type A) receptors have been shown to play a role in oligodendrocyte differentiation and proliferation in the neonatal brain and may be a key factor in white matter injury and myelination in IUGR neonates. Whether there are impairments to the GABAergic system and neuronal cytoskeleton in IUGR brain has yet to be elucidated...
February 17, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#14
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28214986/astrocyte-sodium-signalling-and-panglial-spread-of-sodium-signals-in-brain-white-matter
#15
Behrouz Moshrefi-Ravasdjani, Evelyn L Hammel, Karl W Kafitz, Christine R Rose
In brain grey matter, excitatory synaptic transmission activates glutamate uptake into astrocytes, inducing sodium signals which propagate into neighboring astrocytes through gap junctions. These sodium signals have been suggested to serve an important role in neuro-metabolic coupling. So far, it is unknown if astrocytes in white matter-that is in brain regions devoid of synapses-are also able to undergo such intra- and intercellular sodium signalling. In the present study, we have addressed this question by performing quantitative sodium imaging in acute tissue slices of mouse corpus callosum...
February 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28212663/isolation-of-primary-microglia-from-the-human-post-mortem-brain-effects-of-ante-and-post-mortem-variables
#16
Mark R Mizee, Suzanne S M Miedema, Marlijn van der Poel, Adelia, Karianne G Schuurman, Miriam E van Strien, Jeroen Melief, Joost Smolders, Debbie A Hendrickx, Kirstin M Heutinck, Jörg Hamann, Inge Huitinga
Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to fully understand the role of microglia in neurological and psychiatric disorders, it is crucial to study primary human microglia from brain donors. We have developed a rapid procedure for the isolation of pure human microglia from autopsy tissue using density gradient centrifugation followed by CD11b-specific cell selection...
February 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28207873/classification-of-brain-disease-in-magnetic-resonance-images-using-two-stage-local-feature-fusion
#17
Tao Li, Wu Li, Yehui Yang, Wensheng Zhang
BACKGROUND: Many classification methods have been proposed based on magnetic resonance images. Most methods rely on measures such as volume, the cerebral cortical thickness and grey matter density. These measures are susceptible to the performance of registration and limited in representation of anatomical structure. This paper proposes a two-stage local feature fusion method, in which deformable registration is not desired and anatomical information is represented from moderate scale...
2017: PloS One
https://www.readbyqxmd.com/read/28207659/evaluation-of-dti-parameter-ratios-and-diffusion-tensor-tractography-grading-in-the-diagnosis-and-prognosis-prediction-of-cervical-spondylotic-myelopathy
#18
Kun Wang, Zhi Chen, Fan Zhang, Qingxin Song, Canglong Hou, Yixing Tang, Jun Wang, Shiyue Chen, Yun Bian, Qiang Hao, Hongxing Shen
STUDY DESIGN: Prospective cohort. OBJECTIVE: To explore the correlations between diffusion tensor imaging (DTI) ratios and diffusion tensor tractography (DTT) grading with clinical symptoms and outcomes of cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: In addition to magnetic resonance imaging (MRI) and computed tomography, DTI may be useful in understanding pathophysiology of spinal cord in earlier stages of the CSM but it may be confounded by age and cervical level, and previous studies had small sample sizes...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28205364/altered-neural-mechanisms-of-cognitive-control-in-patients-with-primary-progressive-multiple-sclerosis-an-effective-connectivity-study
#19
Ekaterina Dobryakova, Maria Assunta Rocca, Paola Valsasina, John DeLuca, Massimo Filippi
Primary progressive multiple sclerosis (PPMS) leads to physical and cognitive disability. Specifically, cognitive deficits in PPMS have been explained by both grey matter atrophy and white matter lesions. However, existing research still lacks in the understanding of how the brain of a patient with PPMS functions under cognitive control demands. Thus, the aim of the current study was to examine information integration in patients with PPMS using a search-based effective connectivity method. Fourteen patients with PPMS and 22 age- and gender-matched healthy controls (HC) performed the Stroop task, a cognitively demanding interference task that taxes neural resources required for cognitive control and response inhibition...
February 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28192828/mr-spectroscopy-findings-in-retired-professional-rugby-league-players
#20
Andrew J Gardner, Grant L Iverson, Magdalena Wojtowicz, Christopher R Levi, Frances Kay-Lambkin, Peter W Schofield, Ross Zafonte, Sandy R Shultz, Alexander P Lin, Peter Stanwell
The aim of this study was to examine brain neurometabolite concentrations in retired rugby league players who had a history of numerous self-reported concussions. Participants were 16 retired professional rugby league players (ages 30-45 years) with an extensive history of concussion and participation in contact sports, and 16 age- and education-matched controls who had no history of neurotrauma or participation in contact sports. All completed a clinical interview, psychological and cognitive testing, and magnetic resonance spectroscopy (MRS) investigation...
February 13, 2017: International Journal of Sports Medicine
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