keyword
https://read.qxmd.com/read/38533724/atypical-co-development-of-the-thalamus-and-cortex-in-autism-evidence-from-age-related-white-gray-contrast-change
#1
JOURNAL ARTICLE
Gleb Bezgin, John D Lewis, Vladimir S Fonov, D Louis Collins, Alan C Evans
Recent studies have shown that white-gray contrast (WGC) of either cortical or subcortical gray matter provides for accurate predictions of age in typically developing (TD) children, and that, at least for the cortex, it changes differently with age in subjects with autism spectrum disorder (ASD) compared to their TD peers. Our previous study showed different patterns of contrast change between ASD and TD in sensorimotor and association cortices. While that study was confined to the cortex, we hypothesized that subcortical structures, particularly the thalamus, were involved in the observed cortical dichotomy between lower and higher processing...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38532791/global-sensitivity-of-eeg-source-analysis-to-tissue-conductivity-uncertainties
#2
JOURNAL ARTICLE
Johannes Vorwerk, Carsten H Wolters, Daniel Baumgarten
INTRODUCTION: To reliably solve the EEG inverse problem, accurate EEG forward solutions based on a detailed, individual volume conductor model of the head are essential. A crucial-but often neglected-aspect in generating a volume conductor model is the choice of the tissue conductivities, as these may vary from subject to subject. In this study, we investigate the sensitivity of EEG forward and inverse solutions to tissue conductivity uncertainties for sources distributed over the whole cortex surface...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38530121/gray-matter-volume-associations-in-youth-with-adhd-features-of-inattention-and-hyperactivity-impulsivity
#3
JOURNAL ARTICLE
Gabrielle E Reimann, Hee Jung Jeong, E Leighton Durham, Camille Archer, Tyler M Moore, Fanual Berhe, Randolph M Dupont, Antonia N Kaczkurkin
BACKGROUND: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions. METHODS: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38530116/gray-matter-atrophy-and-white-matter-lesions-burden-in-delayed-cognitive-decline-following-carbon-monoxide-poisoning
#4
JOURNAL ARTICLE
Yanli Zhang, Tianhong Wang, Shuaiwen Wang, Xin Zhuang, Jianlin Li, Shunlin Guo, Junqiang Lei
Gray matter (GM) atrophy and white matter (WM) lesions may contribute to cognitive decline in patients with delayed neurological sequelae (DNS) after carbon monoxide (CO) poisoning. However, there is currently a lack of evidence supporting this relationship. This study aimed to investigate the volume of GM, cortical thickness, and burden of WM lesions in 33 DNS patients with dementia, 24 DNS patients with mild cognitive impairment, and 51 healthy controls. Various methods, including voxel-based, deformation-based, surface-based, and atlas-based analyses, were used to examine GM structures...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38528368/where-alcohol-use-disorder-meets-interoception-a-meta-analytic-view-on-structural-and-functional-neuroimaging-data
#5
JOURNAL ARTICLE
Markus Muehlhan, Carolin Spindler, Sandra Nowaczynski, Claudius Buchner, Maximilian Fascher, Sebastian Trautmann
Alcohol use disorder (AUD) has been associated with changes in the processing of internal body signals, known as interoception. Changes in brain structure, particularly in the insula, are thought to underlie impaired interoception. As studies specifically investigating this association are largely lacking, this analysis takes an approach that compares meta-analytic results on interoception with recently published meta-analytic results on gray matter reduction in AUD. A systematic literature search identified 25 eligible interoception studies...
March 25, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38528027/progressive-increase-of-brain-gray-matter-volume-in-individuals-with-regular-soccer-training
#6
JOURNAL ARTICLE
Ju Li, Yaping Cao, Minghao Huang, Zhe Qin, Jian Lang
The study aimed to investigate alterations in gray matter volume in individuals undergoing regular soccer training, using high-resolution structural data, while also examining the temporal precedence of such structural alterations. Both voxel-based morphometry and source-based morphometry (SBM) methods were employed to analyze volumetric changes in gray matter between the soccer and control groups. Additionally, a causal network of structural covariance (CaSCN) was built using granger causality analysis on brain structural data ordering by training duration...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527450/cerebral-tau-deposition-in-co-morbid-progressive-supranuclear-palsy-and-amyotrophic-lateral-sclerosis-an-18f-flortaucipir-and-7t-mri-study
#7
JOURNAL ARTICLE
Ian Cheong, Yong Du, Gwenn Smith, Jun Hua, Xu Li, Alexander Pantelyat
Introduction Progressive supranuclear palsy (PSP) is a four-repeat tauopathy characterized by multiple clinicopathologic subtypes. Advanced neuroimaging techniques have shown an early ability to distinguish PSP subtypes non-invasively for improved diagnosis. This study utilized tau-PET imaging and MRI techniques at 7 Tesla (7T) to determine the neuroimaging profile of a participant with comorbid PSP and amyotrophic lateral sclerosis (ALS). Method [18F]-flortaucipir PET imaging was performed on one participant with PSP-ALS, one participant with typical PSP (Richardson's syndrome; PSP-RS), and 15 healthy control volunteers...
March 25, 2024: Neuro-degenerative Diseases
https://read.qxmd.com/read/38526835/biomarkers-of-preschool-children-with-autism-spectrum-disorder-quantitative-analysis-of-whole-brain-tissue-component-volumes-intelligence-scores-ados-css-and-ages-of-first-word-production-and-walking-onset
#8
JOURNAL ARTICLE
Xiang Zhou, Wu-Sheng Lin, Feng-Yun Zou, Shuang-Shuang Zhong, Ya-Yin Deng, Xiao-Wen Luo, Li-Shan Shen, Shi-Huan Wang, Ruo-Mi Guo
BACKGROUND: Preschooling is a critical time for intervention in children with autism spectrum disorder (ASD); thus, we analyzed brain tissue component volumes (BTCVs) and clinical indicators in preschool children with ASD to identify new biomarkers for early screening. METHODS: Eighty preschool children (3-6 years) with ASD were retrospectively included. The whole-brain myelin content (MyC), white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and non-WM/GM/MyC/CSF brain component volumes were obtained using synthetic magnetic resonance imaging (SyMRI)...
March 25, 2024: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/38526486/trends-in-intracranial-and-cerebral-volumes-of-framingham-heart-study-participants-born-1930-to-1970
#9
JOURNAL ARTICLE
Charles DeCarli, Pauline Maillard, Matthew P Pase, Alexa S Beiser, Daniel Kojis, Claudia L Satizabal, Jayandra J Himali, Hugo J Aparicio, Evan Fletcher, Sudha Seshadri
IMPORTANCE: Human brain development and maintenance is under both genetic and environmental influences that likely affect later-life dementia risk. OBJECTIVE: To examine environmental influences by testing whether time-dependent secular differences occurred in cranial and brain volumes and cortical thickness over birth decades spanning 1930 to 1970. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the community-based Framingham Heart Study cohort for participants born in the decades 1930 to 1970...
March 25, 2024: JAMA Neurology
https://read.qxmd.com/read/38525561/structural-mri-measures-are-associated-with-fatigue-severity-and-persistence-in-a-large-real-world-cohort-of-people-with-multiple-sclerosis
#10
JOURNAL ARTICLE
Alexandra C Simpson, Chen Hu, Ellen M Mowry, Robert T Naismith, Kathryn C Fitzgerald, Bardia Nourbakhsh
BACKGROUND: Results of research on radiological hallmarks of multiple sclerosis (MS) fatigue have been conflicting. OBJECTIVE: To investigate the associations of lesion and brain compartment volumes with fatigue severity and persistence in people with multiple sclerosis (PwMS). METHODS: The Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network collects standardized data during routine care of PwMS from 10 healthcare institutions...
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38523567/alzheimer-s-disease-progression-detection-based-on-optical-fluence-rate-measurements-using-alternative-laser-wavelengths
#11
JOURNAL ARTICLE
Shimaa Mahdy, Hala S Abuelmakarem
Alzheimer's disease (AD) levels have increased globally, which is considered the sixth reason for deaths. So, a requirement exists for economic and quantitative methods to follow up the gradual progression of AD. The current study presents a simulation for a non-irradiated, safe, wearable, and noninvasive mobile approach for detecting the progression of Alzheimer's brain atrophy using the optical diffusion technique and for investigating the difference between the normal and the diseased brain. The virtual study was accomplished using COMSOL Multiphysics...
March 25, 2024: International Journal for Numerical Methods in Biomedical Engineering
https://read.qxmd.com/read/38523436/evolution-of-staining-methods-in-neuroanatomy-impetus-for-emanation-of-neuron-doctrine-during-the-turn-of-20th-century
#12
REVIEW
Sanjib Kumar Ghosh, Jerzy A Walocha
The nervous system is distinctive as compared to other tissue systems in human body owing to intricate structural organization. Histological studies played a key role in unveiling complex details of nervous tissue. However, the process of developing suitable staining method for nerve cells was arduous and spanned across almost half a century. The present study explored details of the journey involving quest for propitious staining method in neuroanatomy culminating in promulgation of neuron doctrine at the onset of 20th century...
March 24, 2024: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://read.qxmd.com/read/38522767/pain-relief-related-structural-brain-alterations-in-trigeminal-neuralgia-induced-by-non-invasive-stereotactic-radiosurgery-a-pilot-study
#13
JOURNAL ARTICLE
Jonas Kolodziej, Bogdan Pintea, Jan Patrick Boström, Burkhard Pleger
PURPOSE: Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. MATERIALS/METHODS: Combining T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) and multiple-regression analyses, we assessed gray matter maps of TN patients to investigate changes in gray matter volume (GMV) from before to half a year after stereotactic radiosurgery (SRS)...
March 22, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38521789/the-genetic-architecture-of-multimodal-human-brain-age
#14
JOURNAL ARTICLE
Junhao Wen, Bingxin Zhao, Zhijian Yang, Guray Erus, Ioanna Skampardoni, Elizabeth Mamourian, Yuhan Cui, Gyujoon Hwang, Jingxuan Bao, Aleix Boquet-Pujadas, Zhen Zhou, Yogasudha Veturi, Marylyn D Ritchie, Haochang Shou, Paul M Thompson, Li Shen, Arthur W Toga, Christos Davatzikos
The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10-8 ). A gene-drug-disease network highlighted genes linked to GM-BAG for treating neurodegenerative and neuropsychiatric disorders and WM-BAG genes for cancer therapy...
March 23, 2024: Nature Communications
https://read.qxmd.com/read/38521776/a-multi-site-study-on-sex-differences-in-cortical-thickness-in-non-demented-parkinson-s-disease
#15
JOURNAL ARTICLE
Javier Oltra, Barbara Segura, Antonio P Strafella, Thilo van Eimeren, Naroa Ibarretxe-Bilbao, Maria Diez-Cirarda, Carsten Eggers, Olaia Lucas-Jiménez, Gemma C Monté-Rubio, Natalia Ojeda, Javier Peña, Marina C Ruppert, Roser Sala-Llonch, Hendrik Theis, Carme Uribe, Carme Junque
Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson's disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65...
March 23, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38520368/brain-reserve-affects-the-expression-of-cognitive-reserve-networks
#16
JOURNAL ARTICLE
Annabell Coors, Seonjoo Lee, Yunglin Gazes, Margaret Gacheru, Christian Habeck, Yaakov Stern
Cognitive reserve (CR) explains differential susceptibility of cognitive performance to neuropathology. However, as brain pathologies progress, cognitive decline occurs even in individuals with initially high CR. The interplay between the structural brain health (= level of brain reserve) and CR-related brain networks therefore requires further research. Our sample included 142 individuals aged 60-70 years. National Adult Reading Test intelligence quotient (NART-IQ) was our CR proxy. On an in-scanner Letter Sternberg task, we used ordinal trend (OrT) analysis to extract a task-related brain activation pattern (OrT slope) for each participant that captures increased expression with task load (one, three, and six letters)...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38519138/evaluation-of-ivim-in-the-spinal-cord-of-multiple-sclerosis-patients
#17
JOURNAL ARTICLE
Brian Johnson, Christine Heales
PURPOSE: To evaluate the ability of intravoxel incoherent motion (IVIM), a perfusion-weighted imaging technique, to differentiate microcirculation changes in the spinal cord of patients with multiple sclerosis (MS) compared with healthy individuals. METHODS: Fifteen healthy individuals and 15 individuals with MS underwent IVIM magnetic resonance (MR) imaging using a 3 T scanner with 2-D axial gradient recalled echo and 2-D axial diffusion-weighted imaging (DWI) sequences...
March 2024: Radiologic Technology
https://read.qxmd.com/read/38517788/longitudinal-relationship-between-brain-atrophy-patterns-cognitive-decline-and-cerebrospinal-fluid-biomarkers-in-alzheimer-s-disease-explored-by-orthonormal-projective-non-negative-matrix-factorization
#18
JOURNAL ARTICLE
Lan Shui, Dean Shibata, Kwun Chuen Gary Chan, Wenbo Zhang, Junhyoun Sung, David R Haynor
BACKGROUND: Longitudinal magnetic resonance imaging (MRI) has been proposed for tracking the progression of Alzheimer's disease (AD) through the assessment of brain atrophy. OBJECTIVE: Detection of brain atrophy patterns in patients with AD as the longitudinal disease tracker. METHODS: We used a refined version of orthonormal projective non-negative matrix factorization (OPNMF) to identify six distinct spatial components of voxel-wise volume loss in the brains of 83 subjects with AD from the ADNI3 cohort relative to healthy young controls from the ABIDE study...
March 20, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38517785/brain-age-is-associated-with-cognitive-outcomes-of-cholinesterase-inhibitor-treatment-in-patients-with-mild-cognitive-impairment
#19
JOURNAL ARTICLE
Wen-Yih Isaac Tseng, Yung-Chin Hsu, Li-Kai Huang, Chien-Tai Hong, Yueh-Hsun Lu, Jia-Hung Chen, Chin-Kun Fu, Lung Chan
BACKGROUND: The effect of cholinesterase inhibitor (ChEI) on mild cognitive impairment (MCI) is controversial. Brain age has been shown to predict Alzheimer's disease conversion from MCI. OBJECTIVE: The study aimed to show that brain age is related to cognitive outcomes of ChEI treatment in MCI. METHODS: Brain MRI, the Clinical Dementia Rating (CDR) and Mini-Mental State Exam (MMSE) scores were retrospectively retrieved from a ChEI treatment database...
March 21, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38517173/plasma-homocysteine-level-estradiol-level-and-brain-atrophy-a-mendelian-randomization-study
#20
JOURNAL ARTICLE
Wen Gao, Wei-Wen Zhu, Ya-Huan Yu, Juan Wang
OBJECTIVES: Observational studies link elevated plasma homocysteine (Hcy) with vascular disease. Our aim was to assess the gender difference in the association between the plasma tHcy level and brain atrophy and identify the possible influencer. We employed Mendelian randomization (MR) to explore the causal relationship between plasma tHcy level, estradiol level, and brain atrophy. METHODS: A total of 687 patients with brain atrophy were included, and gender-specific subgroup analyses in association between tHcy and brain atrophy are conducted...
March 1, 2024: Cerebral Cortex
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