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https://www.readbyqxmd.com/read/28604372/adaptive-region-growing-with-maximum-curvature-strategy-for-tumor-segmentation-in-18-f-fdg-pet
#1
Shan Tan, Laquan Li, Wookjin Choi, Min Kyu Kang, Warren D D'Souza, Wei Lu
Accurate tumor segmentation in PET is crucial in many oncology applications. We developed an adaptive region-growing (ARG) algorithm with a maximum curvature strategy (ARG_MC) for tumor segmentation in PET. The ARG_MC repeatedly applied a confidence connected region-growing algorithm with increasing relaxing factor f. The optimal relaxing factor (ORF) was then determined at the transition point on the f-volume curve, where the volume just grew from the tumor into the surrounding normal tissues. The ARG_MC along with five widely used algorithms were tested on a phantom with 6 spheres at different signal to background ratios and on two clinic datasets including 20 patients with esophageal cancer and 11 patients with non-Hodgkin lymphoma (NHL)...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28603997/inhibition-of-human-ugt1a1-mediated-bilirubin-glucuronidation-by-polyphenolic-acids-impact-safety-of-popular-salvianolic-acid-a-b-containing-drugs-and-herbal-products
#2
Guo Ma, Ying Zhang, Wenyan Chen, Zhifang Tang, Xiaoming Xin, Ping Yang, Xiaoqin Liu, Weimin Cai, Ming Hu
Bilirubin-related adverse reactions (ADR, e.g., jaundice and hyperbilirubinemia) induced by herbs rich in certain polyphenolic acids are widely reported. However, the causes and the mechanisms underlying these ADR are not well understood. The purpose of this article is to determine the mechanism by which certain polyphenolic acids inhibit UGT1A1-mediated bilirubin glucuronidation, leading to jaundice or hyperbilirubinemia. We investigated in vitro inhibitory effects on bilirubin glucuronidation of salvianolic acid A (SAA), salvianolic acid B (SAB), danshensu (DSS), protocatechuic aldehyde (PA), and rosmarinic acid (RA), as well as two Salvia miltiorrhiza injections (DSI and CDI) rich in polyphenolic acids...
June 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28594880/application-of-the-3d-slicer-chest-imaging-platform-segmentation-algorithm-for-large-lung-nodule-delineation
#3
Stephen S F Yip, Chintan Parmar, Daniel Blezek, Raul San Jose Estepar, Steve Pieper, John Kim, Hugo J W L Aerts
PURPOSE: Accurate segmentation of lung nodules is crucial in the development of imaging biomarkers for predicting malignancy of the nodules. Manual segmentation is time consuming and affected by inter-observer variability. We evaluated the robustness and accuracy of a publically available semiautomatic segmentation algorithm that is implemented in the 3D Slicer Chest Imaging Platform (CIP) and compared it with the performance of manual segmentation. METHODS: CT images of 354 manually segmented nodules were downloaded from the LIDC database...
2017: PloS One
https://www.readbyqxmd.com/read/28589958/astronomical-pacing-of-the-global-silica-cycle-recorded-in-mesozoic-bedded-cherts
#4
Masayuki Ikeda, Ryuji Tada, Kazumi Ozaki
The global silica cycle is an important component of the long-term climate system, yet its controlling factors are largely uncertain due to poorly constrained proxy records. Here we present a ∼70 Myr-long record of early Mesozoic biogenic silica (BSi) flux from radiolarian chert in Japan. Average low-mid-latitude BSi burial flux in the superocean Panthalassa is ∼90% of that of the modern global ocean and relative amplitude varied by ∼20-50% over the 100 kyr to 30 Myr orbital cycles during the early Mesozoic...
June 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28573598/ecological-dissimilarity-among-land-use-land-cover-types-improves-a-heterogeneity-index-for-predicting-biodiversity-in-agricultural-landscapes
#5
Akira Yoshioka, Keita Fukasawa, Yoshio Mishima, Keiko Sasaki, Taku Kadoya
Land-use/land-cover heterogeneity is among the most important factors influencing biodiversity in agricultural landscapes and is the key to the conservation of multi-habitat dwellers that use both terrestrial and aquatic habitats. Heterogeneity indices based on land-use/land-cover maps typically do not integrate ecological dissimilarity between land-use/land-cover types. Here, we applied the concept of functional diversity to an existing land-use/land-cover diversity index (Satoyama index) to incorporate ecological dissimilarity and proposed a new index called the dissimilarity-based Satoyama index (DSI)...
June 1, 2017: Ambio
https://www.readbyqxmd.com/read/28557301/factors-influencing-the-quality-of-life-of-hemodialysis-patients-according-to-symptom-cluster
#6
Hye Yeung Shim, Mi-Kyoung Cho
AIM AND OBJECTIVES: To identify the characteristics in each symptom cluster and factors influencing the quality of life of hemodialysis patients in Korea according to cluster. BACKGROUND: Despite developments in renal replacement therapy, hemodialysis still restricts the activities of daily living due to pain and impairs physical functioning induced by the disease and its complications. DESIGN: Descriptive survey. 230 dialysis patients aged >18 years...
May 30, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28551986/the-fate-and-effect-of-dissolved-silicon-within-wastewater-treatment-effluent
#7
Timothy J Maguire, Robinson W Fulweiler
In large rivers the ratios of silicon (Si):nitrogen (N):phosphorous (P) have changed dramatically as anthropogenic additions of N or P are not matched by Si. Wastewater effluent is a recognized source of N and P to coastal environments, however few previous studies have examined the Si load of a large wastewater plant's effluent or the molar ratios of Si:N and Si:P in effluent. We examine annual flux of dissolved silicon (DSi) carried by effluent from the second largest treatment plant by flow in the United States (Deer Island Treatment Plant, DITP, Boston, MA)...
May 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28539180/visual-and-hearing-impairment-and-retirement-in-older-adults-a-population-based-cohort-study
#8
Bamini Gopinath, Gerald Liew, George Burlutsky, Catherine M McMahon, Paul Mitchell
OBJECTIVE: Impaired vision and hearing are common among older adults and have been shown to reduce functional independence and to reduce quality of life. This cohort study investigated the cross-sectional and temporal associations between objectively measured dual sensory impairment (DSI) and retirement from employment. STUDY DESIGN: 2409 Blue Mountains Eye Study participants aged 55+ years at baseline were included for analyses. MAIN OUTCOME MEASURES: Visual impairment was defined as visual acuity less than 20/40 (better eye), and hearing impairment as average pure-tone air conduction threshold >25dB HL (500-4000Hz, better ear)...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28537462/symptom-prevalence-and-the-negative-emotional-states-in-end-stage-renal-disease-patients-with-or-without-renal-replacement-therapy-a-cross-sectional-analysis
#9
Wan Zul Haikal Wan Zukiman, Hayati Yaakup, Nor Fadhlina Zakaria, Shamsul Azhar Bin Shah
BACKGROUND: Limited comparative data are available on the symptom severity and burden of dialyzed versus nondialyzed end-stage renal disease (ESRD) patients and their association with negative emotional states. OBJECTIVE: To investigate the prevalence of symptom burden and severity of ESRD patients and correlate the findings with their psychological status. METHODS: This was a cross-sectional study of dialyzed (N = 87) and nondialyzed (N = 100) patients...
May 24, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28516296/substrate-coated-illumination-droplet-spray-ionization-real-time-monitoring-of-photocatalytic-reactions
#10
Hong Zhang, Na Li, Dandan Zhao, Jie Jiang, Hong You
Real-time monitoring of photocatalytic reactions facilitates the elucidation of the mechanisms of the reactions. However, suitable tools for real-time monitoring are lacking. Herein, a novel method based on droplet spray ionization named substrate-coated illumination droplet spray ionization (SCI-DSI) for direct analysis of photocatalytic reaction solution is reported. SCI-DSI addresses many of the analytical limitations of electrospray ionization (ESI) for analysis of photocatalytic-reaction intermediates, and has potential for both in situ analysis and real-time monitoring of photocatalytic reactions...
May 17, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28500597/blood-pressure-monitoring-using-radio-telemetry-method-in-mice
#11
Yu Wang, Sean E Thatcher, Lisa A Cassis
The TA11PA-C10 implantable transmitter (Data Sciences International, DSI) is designed to measure blood pressure (BP) and activity in freely moving laboratory mice. The fluid filled catheter is placed in the free flowing blood of the systemic artery (inserted into the left carotid artery and extended into the aorta), and the transmitter body is placed in a benign location for long-term biocompatibility. The transmitter can be used to monitor BP in mice (as small as 17 g) under normal physiological and unrestricted conditions 24 h a day while remaining free from stress associated with human interaction...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28494786/compositionally-and-functionally-distinct-sinus-microbiota-in-chronic-rhinosinusitis-patients-have-immunological-and-clinically-divergent-consequences
#12
Emily K Cope, Andrew N Goldberg, Steven D Pletcher, Susan V Lynch
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this heterogeneity is poorly understood. We sought to address the hypothesis that a limited number of compositionally distinct pathogenic bacterial microbiota exist in CRS patients and invoke discrete immune responses and clinical phenotypes in CRS patients. RESULTS: Sinus brushings from patients with CRS (n = 59) and healthy individuals (n = 10) collected during endoscopic sinus surgery were analyzed using 16S rRNA gene sequencing, predicted metagenomics, and RNA profiling of the mucosal immune response...
May 12, 2017: Microbiome
https://www.readbyqxmd.com/read/28478912/quality-assurance-of-radiotherapy-in-the-ongoing-eortc-1219-dahanca-29-trial-for-hpv-p16-negative-squamous-cell-carcinoma-of-the-head-and-neck-results-of-the-benchmark-case-procedure
#13
Melissa Christiaens, Sandra Collette, Jens Overgaard, Vincent Gregoire, Joanna Kazmierska, Pierre Castadot, Jordi Giralt, Warren Grant, Milan Tomsej, Raquel Bar-Deroma, Angelo F Monti, Coen Wilhelm Hurkmans, Damien Charles Weber
BACKGROUND AND PURPOSE: The phase III EORTC 1219-DAHANCA 29 intergroup trial evaluates the influence of nimorazole in patients with locally advanced head and neck cancer when treated with accelerated radiotherapy (RT) in combination with chemotherapy. This article describes the results of the RT Benchmark Case (BC) performed before patient inclusion. MATERIALS AND METHODS: The participating centers were asked to perform a 2-step BC, consisting of (1) a delineation and (2) a planning exercise according to the protocol guidelines...
May 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28471526/preterm-infants-at-discharge-nap-polysomnography-versus-24-hour-oximetry
#14
Tamsin Roberts, Angela Campbell, Peter Larsen, Dawn Elder
AIM: This study aimed to determine whether measures of intermittent hypoxia derived from 24-hour oximetry correlate with measures of apnoea derived from modified nap polysomnography undertaken for preterm infants before discharge. METHODS: Infants born ≤32 weeks gestation were recruited from the Neonatal Intensive Care Unit, and had a modified polysomnography to assess their respiratory stability once they were ≥35 weeks postmenstrual age. Infants were defined as unstable if they had more than 10 obstructive events per hour or any apnoea of > 20 seconds in length...
May 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28465251/danshen-injection-prevents-heart-failure-by-attenuating-post-infarct-remodeling
#15
Lingyan Wang, Jiahui Yu, Patrick Asare Fordjour, Xiaoxue Xing, Hui Gao, Yanyan Li, Lingyan Li, Yan Zhu, Xiumei Gao, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood circulation and dispel blood stasis. Danshen decoction or liquor-fried Danshen (with grain-based liquor) which is cool in nature is traditionally used to 'cool the blood' and reduce the swelling of sores and abscesses...
April 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28456905/versatile-robust-and-efficient-tractography-with-constrained-higher-order-tensor-fodfs
#16
Michael Ankele, Lek-Heng Lim, Samuel Groeschel, Thomas Schultz
PURPOSE: Develop a multi-fiber tractography method that produces fast and robust results based on input data from a wide range of diffusion MRI protocols, including high angular resolution diffusion imaging, multi-shell imaging, and clinical diffusion spectrum imaging (DSI) METHODS: In a unified deconvolution framework for different types of diffusion MRI protocols, we represent fiber orientation distribution functions as higher-order tensors, which permits use of a novel positive definiteness constraint (H-psd) that makes estimation from noisy input more robust...
April 29, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28437343/spinopelvic-alignment-by-different-surgical-methods-in-the-treatment-of-degenerative-sagittal-imbalance-of-the-lumbar-spine
#17
Dong-Gune Chang, Kee-Yong Ha, Young-Hoon Kim, Eun-Whan Lee
STUDY DESIGN: A retrospective comparative study. OBJECTIVE: To compare pedicle subtraction osteotomy (PSO) and iliac fixation (ILF) without osteotomy as methods of correcting lumbar spine deformities due to degenerative sagittal imbalance (DSI) through the evaluation of the changes in spinopelvic alignment. SUMMARY OF BACKGROUND DATA: Many papers have reported the surgical results after PSO and ILF for patients with fixed adult deformities...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28428703/comparative-study-of-two-elisa-kits-for-estimation-of-antibodies-to-hepatitis-b-virus-in-human-normal-immunoglobulin-and-specific-immunoglobulin-intended-for-intravenous-or-intramuscular-use
#18
J P Prasad, Y Madhu, Arushi Mandhan, Payal Garg, Anu Prakash, Varsha Singh, Daud Ali, Prdeep Kumar, Surinder Singh, G R Soni, Varun Singh
Current study is conducted to evaluate method verification of two locally available kits manufactured by DSI & BIORAD for quantitative estimation of Hepatitis B virus antibodies in human normal immunoglobulin by using International standard of National Institute of Biological Standards and Control. Four analyst perform five sets of test in duplicate analysing accuracy, precision, and limit of detection, sensitivity and specificity. Our results suggest that both DSI and BIORAD kits fulfil the validation criteria and are sensitive to detect up to 10 mIU concentration precisely and accurately...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28425172/the-homeostatic-and-circadian-sleep-recovery-responses-after-total-sleep-deprivation-in-mice
#19
Garance Dispersyn, Fabien Sauvet, Danielle Gomez-Merino, Sylvain Ciret, Catherine Drogou, Damien Leger, Thierry Gallopin, Mounir Chennaoui
Many studies on sleep deprivation effects lack data regarding the recovery period. We investigated the 2-day homeostatic and circadian sleep recovery response to 24 h of total sleep deprivation (TSD) induced by brief rotation of an activity wheel. Eight mice were implanted with telemetry transmitters (DSI F40-EET) that recorded simultaneously their electroencephalography (EEG), locomotor activity and temperature during 24 h of baseline (BSL), TSD and 2 days of recovery (D1 and D2). In a second experiment, two groups of five non-implanted mice underwent TSD or ad libitum sleep, after which they were killed, adrenal glands were weighed and blood was collected for analysis of corticosterone concentration...
April 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28411159/in-vivo-visualization-of-connections-among-revised-papez-circuit-hubs-using-full-q-space-diffusion-spectrum-imaging-tractography
#20
Peng-Hu Wei, Zhi-Qi Mao, Fei Cong, Fang-Cheng Yeh, Bo Wang, Zhi-Pei Ling, Shu-Li Liang, Lin Chen, Xin-Guang Yu
Structural connections among the hubs of the revised Papez circuit remain to be elucidated in the human brain. As the original Papez circuit failed to explain functional imaging findings, a more detailed investigation is needed to delineate connections among the circuit's key hubs. Here we acquired diffusion spectrum imaging (DSI) from eight normal subjects and used data from the Human Connectome Project (HCP) to elucidate connections among hubs in the retrosplenial gyrus, hippocampus, mammillary bodies, and anterior thalamic nuclei...
April 12, 2017: Neuroscience
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