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Brain metastasis lung cancer

Masato Nakaya, Shinya Ichimura, Yutaka Kurebayashi, Youichi Mochizuki, Raita Fukaya, Masahito Fukuchi, Koji Fujii
BACKGROUND:  Metastasis from one tumor into another is known as tumor-to-tumor metastasis. We report a case of a contiguous occurrence of meningioma and brain cancer metastasis. PATIENT:  A 91-year-old woman presented with a sudden onset of weakness in her right limbs and gait disturbance. Fourteen years previously, she had a tumor that was suspected to be a meningioma in the left frontal convexity with no change for several years. One year earlier to presentation she was diagnosed with lung carcinoma in the left lower lobe...
October 15, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Chae Hong Lim, Tae Ran Ahn, Seung Hwan Moon, Young Seok Cho, Joon Young Choi, Byung-Tae Kim, Kyung-Han Lee
OBJECTIVES: We investigated the capacity of fluorodeoxyglucose (FDG) PET/CT features for stratifying probability of metastasis for single-bone FDG lesions in non-small-cell lung cancer (NSCLC). METHODS: Subjects were 118 newly diagnosed NSCLC patients with a solitary bone FDG lesion and no evidence of other distant metastasis based on PET/CT, brain MRI, and contrast-enhanced chest CT. Bone lesion SUVmax and CT findings, primary tumor SUVmax , clinical T stage, and N stage were analyzed...
October 12, 2018: European Radiology
Shelvin K Vadi, Bhagwant R Mittal, Ashwani Sood, Gurpreet Singh, Amanjit Bal, Ashwin S Parihar, Anish Bhattacharya, Rajender K Basher, Rakesh Kapoor
PURPOSE: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC. PATIENTS AND METHODS: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59.3±10.9 years; range: 36-79 years) with suspected recurrence...
October 11, 2018: Nuclear Medicine Communications
Antoine Schernberg, Laura Mezquita, Angela Boros, Angela Botticella, Caroline Caramella, Benjamin Besse, Alexandre Escande, David Planchard, Cécile Le Péchoux, Eric Deutsch
OBJECTIVE: To study the prognostic value of baseline leukocytosis or neutrophiliain two retrospective cohorts of stage III Non-Small Cell Lung Cancer (NSCLC) patients. MATERIALS AND METHODS: Clinical records of consecutive previously untreated NSCLC patients in our Institution between June 2001 and September 2016 for stage III NSCLC were collected. The prognostic value of pretreatment leucocyte disorders was examined, with focus on patterns of relapse and survival...
2018: PloS One
Antonin Levy, Cécile Le Péchoux, Hitesh Mistry, Isabelle Martel-Lafay, Andrea Bezjak, Delphine Lerouge, Laetitia Padovani, Paul Taylor, Corinne Faivre-Finn
INTRODUCTION: The impact of the dose and fractionation of thoracic radiotherapy on the risk of developing brain metastasis (BM) has not been evaluated prospectively in LS-SCLC patients receiving prophylactic cerebral irradiation (PCI). METHODS: Data in patients treated with PCI from the CONVERT trial was analysed. RESULTS: 449/547 (82%) received PCI after completion of chemoradiotherapy. Baseline brain imaging consisted of CT-scan in 356/449 patients (79%) and MRI in 83/449 (18%) patients...
October 4, 2018: Journal of Thoracic Oncology
Masoom Raza, Peeyush Prasad, Pragya Gupta, Naveen Kumar, Taruna Sharma, Mandeep Rana, Aaron Goldman, Seema Sehrawat
Brain metastasis is one of the leading causes of death among cancer patients. Cancer cells migrate to various sites and harbor different niche in the body which help cancer cells in their survival. The brain is one of the safest place where cancer cells are protected from immune cells. Breast, lung, and melanoma cancer cells have high propensity to migrate towards the brain. To enter the brain, cancer cells have to cross the blood brain barrier. Survival and finding new niche in the brain are directed by several mechanisms in which different cellular players take part such as astrocytes, microglia, Schwann cells, satellite cells, oligodendrocytes, and ependymal cells...
October 4, 2018: Cancer Metastasis Reviews
Hui Chang, Yuan-Bin Liu, Wei Yi, Jia-Bin Lu, Jie-Xia Zhang
BACKGROUND: Non-small cell lung cancer (NSCLC) with different EGFR mutation types shows distinct sensitivity to tyrosine kinase inhibitors (TKIs). This study developed a patho-clinical profile-based prediction model of TKI-sensitive EGFR mutations. METHODS: The records of 1121 Chinese patients diagnosed with NSCLC from November 2008 to October 2014 (the development set) were reviewed. Multivariate logistic regression was conducted to identify any association between potential predictors and the classic sensitive EGFR mutations (exon 19 deletion and exon 21 L858R point mutation)...
October 3, 2018: Thoracic Cancer
Xuan Wang, Guang-Yang Yu, Mo Chen, Ran Wei, Jinhong Chen, Zheng Wang
Extrahepatic bile duct cancer (EBDC) is a combined type of malignancy mainly consisting of extrahepatic cholangiocarcinoma and gallbladder cancer. Clinically, it is featured with latent symptoms and early metastasis, leading to a poor prognosis. Therefore, this cohort study aimed to depict the possible metastatic patterns of EBDC of diverse sub-types and evaluate the prognostic significance of diverse metastatic destinations with data from the clinical database. Relevant data of total 4061 confirmed EBDC patients diagnosed between 2010 and 2013 from the Surveillance, Epidemiology and End Results (SEER) database was obtained...
September 12, 2018: Cancer Medicine
Marcos Melian, David Lorente, Fernando Aparici, Oscar Juan
Immunotherapy has revolutionized the treatment of non-small cell lung cancer; however, its role in the treatment response of lung brain metastasis is unknown. Understanding immunotherapy activity in the central nervous system is important in order to avoid additional toxicity, such as that associated with the use of cerebral radiotherapy. We present two cases with clinical and radiological progression with increases in size and perilesional edema of brain lesions after treatment with a combination of ipilimumab and nivolumab...
October 1, 2018: Thoracic Cancer
Anna-Maria Barciszewska
Brain metastases are the most common intracranial tumors in adults. They usually origin from: lung, breast, renal cell, and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with molecular approaches. However, their successful application depends on a deep understanding of not only genetic, but also epigenetic background of the disease. That will result in earlier and more precise diagnosis, successful treatment, as well as individualized estimation of clinical outcomes and prognosis...
September 25, 2018: Bioscience Reports
Jamie R Kutasovic, Amy E McCart Reed, Renique Males, Sarah Sim, Jodi M Saunus, Andrew Dalley, Christopher McEvoy, Liana Dedina, Gregory Miller, Stephen Peyton, Lynne Reid, Samir Lal, Colleen Niland, Kaltin Ferguson, Andrew Fellowes, Fares Al-Ejeh, Sunil R Lakhani, Margaret C Cummings, Peter T Simpson
Breast cancer metastasis to gynaecological organs is an understudied pattern of tumour spread. We explored clinico-pathologic and molecular features of these metastases to better understand whether this pattern of dissemination is organotropic or a consequence of wider metastatic dissemination. Primary and metastatic tumours from 54 breast cancer patients with gynaecological metastases were analysed using immunohistochemistry, DNA copy number profiling and targeted sequencing of 386 cancer-related genes. The median age of primary tumour diagnosis amongst patients with gynaecological metastases was significantly younger compared to a general breast cancer population (46...
September 24, 2018: Journal of Pathology. Clinical Research
Rui Zhang, Ping Li, Qin Li, Yunfeng Qiao, Tangpeng Xu, Peng Ruan, Qibin Song, Zhenming Fu
OBJECTIVES: The survival advantage of radiotherapy (RT) for patients with stage IV non-small cell lung cancer (NSCLC) has not been adequately evaluated. METHODS: We analyzed stage IV NSCLC patients enrolled from the Surveillance, Epidemiology, and End Results (SEER) registry through January 2010 to December 2012. Propensity score (PS) analysis with 1:1 nearest neighbor matching method was used to ensure well-balanced characteristics of all comparison groups by histological types and metastatic sites...
September 21, 2018: Cancer Medicine
Tadashi Yamamuro, Kana Inoue, Yasuki Nagai, Daisuke Azuma, Aya Yamamoto, Kantaro Hara, Masaharu Kohara, Takashi Iwata, Shinichi Nakatsuka, Eiichi Morii, Tsunehiko Yamamoto
Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical examination. In addition, laboratory examination showed elevated plasma ACTH and serum cortisol levels...
September 20, 2018: Endocrine Journal
Xi He, Si-Yuan Chen, Zhao Yang, Jie Zhang, Wei Wang, Mei-Yue Liu, Yi Niu, Xiao-Mei Wei, Hong-Min Li, Wan-Ning Hu, Guo-Gui Sun
BACKGROUND: Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. MicroRNAs (miRNAs) have been indicated as crucial actors in cancer biology. Accumulating evidence suggests that miRNAs can be used as diagnostic and prognostic markers for NSCLC. METHODS: The purpose of this study was to characterize and identify the novel biomarker miR-4317 and its targets in NSCLC. The expression of miR-4317 was analyzed by in situ hybridization (ISH) and quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
September 18, 2018: Journal of Experimental & Clinical Cancer Research: CR
Guogui Sun, Xiao Ding, Nan Bi, Lihong Wu, Jingbo Wang, WenJue Zhang, Xin Dong, Ning Lv, Yongmei Song, Qimin Zhan, LuHua Wang
During the last several years, a growing number of studies have shown that microRNAs (miRNAs) participate in cancer metastasis. Brain metastasis (BM) is a frequent complication of lung adenocarcinoma (LAD), and the incidence of locally advanced LAD with BM can be as high as 30-50%. This study was performed to identify the miRNA expression patterns of LAD with BM and to determine the biological role that miRNAs play in tumorigenesis. To this end, we conducted microarray and quantitative PCR analyses to evaluate BM-related miRNAs independently validated from a total of 155 patients with LAD...
September 17, 2018: Cell Death & Disease
Ahmad Walid Ayas, Stefan Grau, Karolina Jablonska, Daniel Ruess, Maximilian Ruge, Simone Marnitz, Roland Goldbrunner, Martin Kocher
PURPOSE: Evaluation of postoperative fractionated local 3D-conformal radiotherapy (3DRT) of the resection cavity in brain metastases. PATIENTS AND METHODS: Between 2011 and 2016, 57 patients underwent resection of a single, previously untreated (37/57, 65%) or recurrent (20/57, 35%) brain metastasis (median maximal diameter 3.5 cm [1.1-6.5 cm]) followed by 3DRT. For definition of the gross tumor volume (GTV), the resection cavity was used and for the clinical target volume (CTV), margins of 1...
September 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Yawen Zheng, Linlin Wang, Weichong Zhao, Yan Dou, Wei Lv, Hongyan Yang, Yuping Sun, Ligang Xing
BACKGROUND: This study aimed to determine the risk factors for brain metastasis (BM) and the prognostic factors for overall survival (OS) in patients with small cell lung cancer without prophylactic cranial irradiation (PCI). PATIENTS AND METHODS: Limited stage small cell lung cancer (LS-SCLC) patients achieving a complete response (CR) or partial response (PR) were enrolled into this study between January 2010 and December 2016. We retrospectively evaluated the influencing factors for time to BM and overall survival (OS)...
September 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Qi Guo, Chao Zhang, Xu Guo, Fang Tao, Yao Xu, Guowei Feng, Xiuxin Han, Zhiwu Ren, Hui Zhang, Pingfang Zhang, Xin Wang, Guowen Wang
Purpose: The purpose of this study was to assess the incidence of and the risk factors and prognostic factors for bone metastasis (BM) in initial metastatic renal cell carcinoma (RCC) based on a large population analysis. Patients and methods: Data were obtained for a total of 45,824 RCC patients recorded in the database of the Surveillance, Epidemiology, and End Results program of the National Cancer Institute between 2010 and 2014. Multivariate logistic and Cox regression analyses were used to identify the risk factors and prognostic factors associated with BM in RCC patients...
2018: Cancer Management and Research
Paweł Krawczyk, Renata Duchnowska, Marcin Nicoś, Dariusz Kowalski, Kamila Wojas-Krawczyk
There are no effective central nervous system (CNS) metastases prevention methods in lung cancer patients. Prophylactic cranial irradiation has a limited effectiveness and relatively high toxicity. Systemic chemotherapy is not relevant in reducing the risk of CNS in lung cancer patients. The understanding of molecular background of brain metastases in non-small cell lung cancer (NSCLC) patients could contribute to the development of personalized treatments for such patients. Areas covered: This article summarizes the latest clinical trials concerning the use of radiotherapy, chemotherapy, molecularly targeted therapies, and immunotherapy in lung cancer patients, with particular consideration of brain lung cancer metastasis prevention...
November 2018: Expert Review of Anticancer Therapy
Kenta Kuramoto, Masahiro Yamamoto, Shuhei Suzuki, Tomomi Sanomachi, Keita Togashi, Shizuka Seino, Chifumi Kitanaka, Masashi Okada
BACKGROUND/AIM: Cancer stem cells (CSCs) are associated with tumorigenesis, recurrence, and metastasis. Cell-cell communication via gap junctions (GJs) between metastatic cancer cells and astrocytes is necessary for brain metastasis. Agents targeting communication between CSCs and astrocytes are expected to suppress brain metastasis. MATERIALS AND METHODS: Using the A549 CSC, a cancer stem-like cell derived from A549, we examined the effect of AS602801, an anti-cancer stem cell agent whose safety has been confirmed in a phase 2 clinical trial, on GJ communication and connexin expression using a dye-transfer assay and immunoblot analysis, respectively...
September 2018: Anticancer Research
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