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Brain metastasis lung cancer

Yasuhiro Chikaishi, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka
Background: The standard therapy for brain metastasis (BM) in non-small cell lung cancer (NSCLC) is radiation therapy (RT), although it is associated with complications such as leukoencephalopathy. In the current report, we retrospectively review data from eight patients who had NSCLC and harbored epidermal growth factor receptor (EGFR) mutations, and who were received erlotinib plus bevacizumab (E+B) as first-line therapy for BM. Methods: Patients were given E+B as first therapy for BM until August 2017 at our institution...
October 2018: Annals of Translational Medicine
Gloria V Echeverria, Emily Powell, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher Bristow, Michael Peoples, Frederick Robinson, Huan Qiu, Jiansu Shao, Sabrina L Jeter-Jones, Xiaomei Zhang, Vandhana Ramamoorthy, Shirong Cai, Wenhui Wu, Giulio Draetta, Stacy L Moulder, William F Symmans, Jeffrey T Chang, Timothy P Heffernan, Helen Piwnica-Worms
Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree of intra-tumoral heterogeneity (ITH), but how ITH contributes to metastasis is unclear. Here, clonal dynamics during metastasis were studied in vivo using two patient-derived xenograft (PDX) models established from the treatment-naive primary breast tumors of TNBC patients diagnosed with synchronous metastasis. Genomic sequencing and high-complexity barcode-mediated clonal tracking reveal robust alterations in clonal architecture between primary tumors and corresponding metastases...
November 29, 2018: Nature Communications
Johannes Leitner, Sebastian Pelster, Veronika Schöpf, Anna S Berghoff, Ramona Woitek, Ulrika Asenbaum, Karl-Heinz Nenning, Georg Widhalm, Barbara Kiesel, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Daniela Prayer, Matthias Preusser, Julia Furtner
OBJECTIVES: This study aimed to assess the correlation of temporal muscle thickness (TMT), measured on routine cranial magnetic resonance (MR) images, with lumbar skeletal muscles obtained on computed tomography (CT) images in brain metastasis patients to establish a new parameter estimating skeletal muscle mass on brain MR images. METHODS: We retrospectively analyzed the cross-sectional area (CSA) of skeletal muscles at the level of the third lumbar vertebra on computed tomography scans and correlated these values with TMT on MR images of the brain in two independent cohorts of 93 lung cancer and 61 melanoma patients (overall: 154 patients) with brain metastases...
2018: PloS One
Yaqi Wang, Wei Bai, Meijian Wang, Ting Yu, Wei Zhang
Long non-coding RNAs (lncRNAs) can serve as oncogenes and tumor suppressors and are involved in tumorigenesis and chemotherapy resistance. Brain cytoplasmic RNA 1 (BCYRN1), as a translational modulator, is an lncRNA comprised of 200 bases that plays an important role in multiple cancers. In this study, we explored the biological role of the lncRNA, BCYRN1, in the development of non-small cell lung cancer (NSCLC). We found that BCYRN1 was increased in NSCLC, and its downregulated expression could suppress NSCLC cell proliferation and cell cycle progression by inhibiting the Wnt/ β -catenin pathway...
April 1, 2019: Journal of Nanoscience and Nanotechnology
Chunhua She, Ruixia Wang, Changhong Lu, Zengfeng Sun, Peng Li, Qiang Yin, Qun Liu, Peng Wang, Wenliang Li
BACKGROUND: Brain metastases (BM) are a common consequence of lung cancer and surgery is effective; however, the factors affecting survival after surgery are unclear. The aim of this study was to identify the outcomes and prognoses of post-metastasectomy patients with BM from non-small cell lung cancer (NSCLC) at a single institution over a 15-year period. METHODS: NSCLC patients who had undergone BM surgery were retrospectively identified. Survival was analyzed using the Kaplan-Meier curve, and univariate and multivariate factors associated with survival were identified using the Cox proportional hazards model...
November 28, 2018: Thoracic Cancer
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Laura G Mendoza-Olivas
BACKGROUND AND PURPOSE: Cancer and stroke are the second and third causes of death worldwide; brain metastases (BM) occur in one third of patients with cancer, any neurologic deficit in these population always prompts the clinician to discard metastases for their presence carries a bad outcome. Both might share clinical presentation and differences in their outcome are not entirely known. The aim was to compare risk factors, clinical presentation, and outcome of cancer patients with BM vs stroke...
November 16, 2018: Current Problems in Cancer
Mauro Loi, Antonio Mazzella, Audrey Mansuet-Lupo, Antonio Bobbio, Emelyne Canny, Pierre Magdeleinat, Jean-François Régnard, Diane Damotte, Jean Trédaniel, Marco Alifano
BACKGROUND: Oligometastatic stage IV Non-small Lung Cancer (NSCLC) patients have a 5-years overall survival of 30% versus 4-6% . We reviewed data and patterns of care of patients affected by oligometastatic NSCLC in our centre between 2001 and 2017. METHODS: We retrospectively reviewed clinical and pathological files of all patients with lung cancer and synchronous isolated adrenal and/or brain metastases, treated by locally ablative treatments (surgery and/or, radiotherapy) of both primary cancer and distant metastasis...
November 23, 2018: Annals of Thoracic Surgery
Weikai Xiao, Shaoquan Zheng, Anli Yang, Xingcai Zhang, Yutian Zou, Hailin Tang, Xiaoming Xie
Background: It was unclear whether breast cancer subtypes are associated with the risk of site-specific metastases. This study aimed to evaluate the relationship between molecular subtypes and distant metastatic sites and their prognostic significance. Methods: We identified 295,213 patients with invasive breast cancer from 2010 to 2014 using the Surveillance, Epidemiology and End Results database. Subtypes were classified into four categories: hormone receptor (HR+ )/human epidermal growth factor receptor 2 (HER2- ), HR+ /HER2+ , HR- /HER2+ , and triple-negative (HR- /HER2- )...
2018: Cancer Management and Research
Bina Kakusa, Summer Han, Sonya Aggarwal, Boxiang Liu, Gordon Li, Scott Soltys, Melanie Hayden Gephart
PURPOSE: Routine brain MRI surveillance frequently diagnoses small, asymptomatic brain metastases from non-small cell lung cancer (NSCLC) that are effectively treated with stereotactic radiosurgery (SRS). A subset of patients, however, may die prior to the onset of symptoms. This study identifies clinical features that distinguish neurologically-asymptomatic NSCLC brain metastases patients that die prior to routine 3 month follow-up after SRS. METHODS: Retrospective chart review from 2007 to 2017 identified 18 patients with neurologically-asymptomatic NSCLC brain metastases who died < 3 months after SRS...
November 20, 2018: Journal of Neuro-oncology
Lijuan Chen, Xiufeng Hu, Huijuan Wu, Yongxu Jia, Jie Liu, Xiaoqian Mu, Hongbo Wu, Yanqiu Zhao
Validated serum biomarkers for patients suffering from non-small cell lung cancer (NSCLC) brain metastasis are urgently needed for early diagnosis, treatment monitoring, and prognostic classification in daily clinical practice. Serum S100B was reported to be a marker of leaky blood-brain barrier (BBB), which was often caused by brain tumors. This study aimed to investigate the role of S100B in NSCLC brain metastasis. The results showed that serum S100B correlated significantly with NSCLC brain metastasis (P < 0...
November 12, 2018: Pathology, Research and Practice
Shingo Miyamoto, Ryutaro Nomura, Kengo Sato, Nobuyasu Awano, Naoyuki Kuse, Minoru Inomata, Takehiro Izumo, Yuriko Terada, Yoshiaki Furuhata, Yuan Bae, Hideo Kunitoh
Background: Radiation therapy might modify the cancer immune environment to enhance the antitumor effect of immune checkpoint inhibitors. We performed a feasibility study of nivolumab following stereotactic radiation therapy for chemotherapy pretreated advanced non-small-cell lung cancer. Patients and methods: Pretreated advanced/recurrent non-small-cell lung cancer patients received stereotactic radiation therapy to one of the disease sites. Nivolumab at a dose of 3 mg/kg was given within 2 weeks after the completion of stereotactic radiation therapy and continued every 2 weeks thereafter until disease progression or unacceptable toxicities...
November 17, 2018: Japanese Journal of Clinical Oncology
Ryohei Ono, Ryoji Ito, Keiko Nakagawa, Shinichi Teshima, Izumi Kitagawa, Hideyasu Sugimoto
BACKGROUND: Metastasis to the pituitary gland is an infrequent clinical problem, and the symptoms caused by metastases have been reported in only 2.5-18.2% of the cases. However, metastasis to the suprasellar lesion has rarely been reported in the literature. To the best of our knowledge, only nine cases of hypothalamic hypopituitarism due to metastases of solid tumors have been reported in English-language journals. CASE PRESENTATION: A 67-year-old Japanese man presented to our hospital with generalized weakness, lethargy, and weight loss...
November 18, 2018: Journal of Medical Case Reports
Kota Takemoto, Nobuyuki Miyahara, Nobuyuki Chikuie, Takao Hamamoto, Takashi Ishino, Tsutomu Ueda, Sachio Takeno
CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Computed tomography and magnetic resonance imaging performed 10 weeks after the primary treatment revealed a residual tumor and brain and lung metastases...
November 12, 2018: Auris, Nasus, Larynx
Tejaswi Worlikar, Eli Vlaisavljevich, Tyler Gerhardson, Joan Greve, Shanshan Wan, Sibu Kuruvilla, Jonathan Lundt, Kimberly Ives, Timothy Hall, Theodore H Welling, Fred Lee, Zhen Xu
Histotripsy fractionates tissue through a mechanical, non-invasive ultrasonic ablation process that precisely controls acoustic cavitation while utilizing real-time ultrasound (US) imaging guidance. This study investigates the potential, feasibility and tumor volume reduction effects of histotripsy for liver cancer ablation in a subcutaneous in vivo murine Hepatocellular Carcinoma (HCC) model. Hep3B tumors were generated in the right flanks of 14 NSG and 7 NOD-SCID mice. The mice were grouped as follows: A (acute, NSG with n=9 treatment and n=1 control), B (chronic, NSG with n=2 treatment and n=2 control) and C (chronic NODSCID, with n=6 treatment and n=1 control)...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yen-Yu Chen, Yuh-Ming Chang, Kuan-Yi Wang, Pei-Ni Chen, You-Cheng Hseu, Ke-Min Chen, Kun-Tu Yeh, Chih-Jung Chen, Li-Sung Hsu
Glioblastoma (GBM) is the most mortality brain cancer in the world. Due to high invasion and drug resistance cause the poor prognosis of GBM. Naringenin, an ingredient of citrus, exhibits many cellular functions such as antioxidant, anti-inflammation, and anticancer. Naringenin inhibits the migration of bladder and lung cancer via modulation of MMP-2 and/or MMP-9 activities, Naringenin inhibits migration and trigger apoptosis in gastric cancer cells through downregulation of AKT pathway. However, the effects of naringenin in GBM still remain to be elucidated...
November 15, 2018: Environmental Toxicology
Jie Zeng, Shuanshuan Xie, Yang Liu, Changxing Shen, Xiaolian Song, Guo-Lei Zhou, Changhui Wang
Cyclin-dependent kinase 5 (CDK5), an atypical member of the cyclin-dependent kinase family, plays an important role in the nervous system. Recent studies have shown that CDK5 is also associated with tumors. However, few studies have been done to investigate the mechanism underlying the connection between CDK5 and cancers. To explore the role of CDK5 in cancers by using an extensive bioinformatics data mining process. We mined the transcriptional, survival, functions and structure of CDK5 gene through databases and in vitro experiments...
2018: Journal of Cancer
Liang Zeng, Yizhi Li, Lili Xiao, Yi Xiong, Li Liu, Wenjuan Jiang, Jianfu Heng, Jingjing Qu, Nong Yang, Yongchang Zhang
Introduction: Data of standard tyrosine kinase inhibitor (TKI) treatment outcome in next-generation sequencing (NGS)-identified ROS1-rearranged non-small-cell lung cancer (NSCLC) were rare. Thus, it is practical and necessary to evaluate the efficacy and influential factors of crizotinib in real-world practice. Patients and methods: A total of 1,466 NSCLC patients with positive targeted NGS test results from September 2015 to January 2018 were enrolled in this real-world retrospective study...
2018: OncoTargets and Therapy
Xiaorong Zhou, Mahesh S Padanad, Bret M Evers, Bethany Smith, Nicole Novaresi, Shruthy Suresh, James A Richardson, Emily Stein, JIngfei Zhu, Robert E Hammer, Kathryn A O'Donnell
PROTOCADHERIN 7 (PCDH7), a transmembrane receptor and member of the Cadherin superfamily, is frequently overexpressed in lung adenocarcinoma and is associated with poor clinical outcome. While PCDH7 was recently shown to promote transformation and facilitate brain metastasis in lung and breast cancers, decreased PCDH7 expression has also been documented in colorectal, gastric, and invasive bladder cancers. These data suggest context-dependent functions for PCDH7 in distinct tumor types. Given that PCDH7 is a potentially targetable molecule on the surface of cancer cells, further investigation of its role in tumorigenesis in vivo is needed to evaluate the therapeutic potential of its inhibition...
November 8, 2018: Molecular Cancer Research: MCR
Maho Ogawa, Tsutomu Namikawa, Toyokazu Oki, Jun Iwabu, Masaya Munekage, Hiromichi Maeda, Takahiko Tamura, Tomoaki Yatabe, Hiroyuki Kitagawa, Ken Dabanaka, Takeki Sugimoto, Michiya Kobayashi, Kazuhiro Hanazaki
The most common sites of breast cancer metastasis are the bone, liver, lung and brain, while gastrointestinal metastasis from breast cancer is rare. We herein present the case of a 68-year-old woman who was admitted to our department with nausea and appetite loss. The patient's medical history included right mastectomy with sentinel lymph node biopsy 5 years earlier for invasive lobular carcinoma, measuring 6.2 cm in greatest diameter, without lymphovascular invasion. Two years after the surgery, the patient developed brain metastasis and underwent metastasectomy to control the neurological symptoms, including unsteadiness and asthenia...
November 2018: Molecular and Clinical Oncology
Sven Hausner, Richard J Bold, Lina Y Cheuy, Helen K Chew, Megan E Daly, Ryan A Davis, Cameron C Foster, Edward J Kim, Julie L Sutcliffe
PURPOSE: The study was undertaken to develop and evaluate the potential of an integrin αv β6 -binding peptide (αv β6 -BP) for noninvasive imaging of a diverse range of malignancies with positron emission tomography (PET). EXPERIMENTAL DESIGN: The peptide αv β6 -BP was prepared on solid phase and radiolabeled with 4-[18 F]fluorobenzoic acid. In vitro testing included ELISA, serum stability, and cell binding studies using a paired αv β6 -expressing and αv β6 -null cell lines...
November 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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