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Brain metastasis lung cancer

Jizhao Wang, Yuchen Sun, Jingkun Qu, Huang Zuo, Xixi Zhao, Lin Liu, Jinteng Feng, Jiansheng Wang, Guangjian Zhang
AIM: We aimed to investigate risk factors and current treatment effects in male breast cancer patients. METHODS: Kaplan-Meier plot, log-rank test, COX model, nomograms and propensity score matching were used. RESULTS: Among stage I-III patients, surgery was associated with better prognosis. In subgroup analysis, performing surgery and no radiation or chemotherapy led to worse prognosis in research group. Among stage IV patients, chemotherapy correlated with better prognosis and radiation led to better breast cancer-specific survival...
August 8, 2018: Future Oncology
Ilaria Attili, Niki Karachaliou, PierFranco Conte, Laura Bonanno, Rafael Rosell
Epidermal growth factor receptor (EGFR) mutation positive non-small cell lung cancer (NSCLC) is a subset of lung cancer with demonstrated response to targeted therapies. However, resistance to the first targeted approach usually occurs within the first year, and it is associated in 50-60% of cases to the T790M resistance mutation. Areas covered: The review provides an overview on the significance of the presence of the T790M mutation, its detection, treatment options and subsequent mechanisms of resistance...
August 6, 2018: Expert Review of Anticancer Therapy
Riyadh Ali Mohammed Hammamy, Khalid Farooqui, Wisam Ghadban
Pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is very common and it accounts approximately to one-third of all primary pulmonary cancers. Although a minority of patients with lung cancer are asymptomatic, which gets usually detected in routine chest radiography, most of the patients present with some symptoms. Lung cancer metastasis may occur virtually in every organ system. Patients with non-small-cell lung cancer commonly have extrathoracic metastases to the adrenal glands, liver, brain, bones, and lymph nodes at presentation...
2018: Case Reports in Medicine
Mahdi Hatamipour, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Thomas P Johnston, Mahnaz Ramezani, Amirhosein Sahebkar
The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo- and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach...
August 4, 2018: Journal of Cellular Physiology
Naghmehossadat Eshghi, Linda Garland, Gagandeep Choudhary, Charles C Hsu, Anna Eshghi, James Han, Russell J Hamilton, Elizabeth Krupinski, Phillip Hsin Kuo
Objective: Chemotherapy followed by prophylactic cranial irradiation (PCI) is associated with increased survival in patients with small cell lung cancer (SCLC) but is associated with fatigue and cognitive impairment. This retrospective study evaluated regional differences in fluorodeoxyglucose (18 F-FDG) uptake of the brain before and after PCI. The null hypothesis was that direct toxic effects on the brain from PCI and chemotherapy are symmetric, thus asymmetric deviations may reflect functional changes due to therapy...
August 3, 2018: Journal of Nuclear Medicine Technology
Amanda Jane Williams Gibson, Haocheng Li, Adrijana D'Silva, Roxana A Tudor, Anifat A Elegbede, Shannon Mary Otsuka, D Gwyn Bebb, Winson Y Cheung
BACKGROUND: To assess the impact of location versus number of extra-pulmonary metastatic sites (EPMS) on survival in stage IV non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Retrospective analysis was conducted on patients diagnosed during 1999-2013 with stage IV, M1b (AJCC 7th edition) NSCLC using the large, institutional Glans-Look Database, which contains patient demographic, clinical, pathological, treatment, and outcome information. We assessed the impact of location and number of EPMS and identified correlates of overall survival using the Kaplan-Meier method and Cox regression...
August 2, 2018: Medical Oncology
Suneel D Kamath, Priya U Kumthekar, Tim J Kruser, Nisha A Mohindra
Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery.
August 2, 2018: Oncologist
In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Woo-Youl Jang, Jae-Young Park, Tae-Wook Song, Sa-Hoe Lim
Objective: We investigated the outcomes of repeat stereotactic radiosurgery (SRS) for metastatic brain tumors that locally recurred despite previous SRS, focusing on the tumor control. Methods: A total of 114 patients with 176 locally recurring metastatic brain tumors underwent repeat SRS after previous SRS. The mean age was 59.4 years (range, 33 to 85), and there were 68 male and 46 female patients. The primary cancer types were non-small cell lung cancer (n=67), small cell lung cancer (n=12), gastrointestinal tract cancer (n=15), breast cancer (n=10), and others (n=10)...
August 1, 2018: Journal of Korean Neurosurgical Society
Emma C Martin, Leon Aarons, James W T Yates
PURPOSE: Epidermal growth factor receptor (EGFR) is thought to play a role in the regulation of cell proliferation; with its activation stimulating tumour growth. EGFR inhibitors have shown promise in the treatment of cancer, particularly in non-small cell lung cancer, however, resistance is observed in the majority of patients. A tumour growth model was developed aiming to explain this resistance. METHODS: The model incorporating populations of both sensitive and resistant cells were fitted to data from a study of EGFR inhibitor AZD3759 in brain metastasis mouse models...
July 27, 2018: Cancer Chemotherapy and Pharmacology
Giovanna Catania, Paola Malaguti, Simona Gasparro, Francesco Cognetti, Antonello Vidiri, Alessandra Fabi
BACKGROUND: Brain metastases develop in approximately 10-25% of patients with metastatic breast cancer (MBC) and are associated with a very poor prognosis. CASE REPORT: We report the case of a 40-year-old woman with MBC and associated lung, bone, liver, and brain metastases, who experienced a time to progression of several months with eribulin after whole-brain radiotherapy (WBRT), 2 lines of chemotherapy, and 1 line of hormonal therapy, maintaining a good toxicity profile...
2018: Oncology
Thiru Prasanna, Christos S Karapetis, David Roder, Jeanne Tie, Robert Padbury, Timothy Price, Rachel Wong, Jeremy Shapiro, Louise Nott, Margaret Lee, Yu Jo Chua, Paul Craft, Cynthia Piantadosi, Michael Sorich, Peter Gibbs, Desmond Yip
BACKGROUND: Pattern of spread in patients with metastatic colorectal cancer (mCRC) is variable and may reflect different biology in subsets of patients. This is a retrospective study to explore the outcome of patients with mCRC based on their site of metastasis at diagnosis and to explore the association between tumor characteristics [KRAS/RAS, BRAF, mismatch repair (MMR) status, site of primary] and the site of metastasis. METHODS: Patients from two Australian databases were divided into six groups based on site of metastasis at time of diagnosis of metastatic disease; lung-only, liver-only, lymph node-only or any patients with brain, bone or peritoneal metastases...
July 23, 2018: Acta Oncologica
Tomasz Matys, Rosalyn Drury, Sarojini David, Doris M Rassl, Wendi Qian, Robert C Rintoul, Nicholas J Screaton
OBJECTIVES: Although detection of brain metastasis can change treatment intent in non-small cell lung carcinoma (NSCLC), head imaging is not routinely performed during initial staging. In our previous study, 4.8% of patients considered for surgical treatment had asymptomatic synchronous brain metastases, encouraging us to include contrast-enhanced head CT (CE-CT) in our routine staging protocol. We present results from a large cohort of potentially resectable NSCLC patients imaged irrespective of the presence of neurological symptoms...
August 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Xueyan Wang, Ye Xu, Weiqing Tang, Lingxiang Liu
BACKGROUND: The role of radiotherapy (RT) combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) remains controversial. Therefore, we conducted a meta-analysis to comprehensively evaluate the efficacy and safety of RT plus EGFR-TKIs in those patients. MATERIALS AND METHODS: Relevant literatures published between 2012 and 2017 were searched. Objective response rate(ORR), disease control rate (DCR), overall survival (OS), intracranial progression-free survival (I-PFS) and adverse events (AEs) were extracted...
July 19, 2018: Translational Oncology
Majid Akrami, Afrooz Sepahdar, Peyman Arasteh, Sedigheh Tahmasebi, Vahid Zangouri, Azam Askari, Babak Pezeshki, Abdolrasoul Talei
BACKGROUND: In here, we evaluated pattern of metastasis and cross-compared clinicopathological features between different age groups with breast cancer (BC). METHODS: This study was conducted in the Shiraz Breast Cancer Registry (largest BC registry in Iran). Patients were classified as < 30 years old (group 1), 30-60 years old (group 2), and > 60 years old (group 3). The three age groups were compared regarding clinical and baseline characteristics...
July 19, 2018: World Journal of Surgical Oncology
Alexander Drilon, Jessica J Lin, Thomas Filleron, Ai Ni, Julie Milia, Isabella Bergagnini, Vaios Hatzoglou, Vamsidhar Velcheti, Michael Offin, Bob Li, David P Carbone, Benjamin Besse, Tony Mok, Mark M Awad, Jurgen Wolf, Dwight Owen, D Ross Camidge, Gregory J Riely, Nir Peled, Mark G Kris, Julien Mazieres, Justin F Gainor, Oliver Gautschi
BACKGROUND: In RET-rearranged lung cancers, data on the frequency of brain metastases and, in particular, the outcomes of multikinase inhibitor therapy in patients with intracranial disease are not well characterized. METHODS: A global, multi-institutional registry (cohort A, n=114) and a bi-institutional data set (cohort B, n=71) of RET-rearranged lung cancer patients were analyzed. Patients were eligible if they had stage IV lung cancers harboring a RET rearrangement by local testing...
July 11, 2018: Journal of Thoracic Oncology
Xiu Hu, Lin-Wen Wu, Xu Weng, Neng-Ming Lin, Chong Zhang
High-dose erlotinib is effective for non-small cell lung cancer patients with brain metastases. The aim of the present study was to investigate whether aspirin could increase the anti-proliferative and anti-metastatic effects of regular erlotinib treatment. The data demonstrated that combining aspirin with erlotinib significantly induced apoptosis and inhibited tumor cell proliferation in several human cancer types. Furthermore, aspirin plus erlotinib significantly induced the activation of E-cadherin and suppression of p38...
August 2018: Oncology Letters
Jin Liu, Zhong Lu, Wenhao Wang, Xiumei Sun
The present study aimed to investigate the expression of programmed death-ligand 1 (PD-L1) in resectable small cell lung cancer (SCLC) and investigate its predictive value for survival and brain metastasis (BM). Postoperative SCLC specimens were immunostained with the SP142 antibody against PD-L1. Positive PD-L1 expression was defined as PD-L1 expression in ≥5% of tumor cells. A total of 80 patients were recruited between January 2010 and December 2012. PD-L1 was expressed in 65.0% (52/80) of all patients and 59...
August 2018: Oncology Letters
Ranmali Ranasinghe, Rajaraman Eri
C-C chemoattractant cytokine (chemokine) receptor 6 (CCR6) and its exclusive binding molecule CCL20 is an extremely important chemokine receptor-ligand pair which controls cell migration and immune induction during inflammatory disease. Not many scientific studies have been undertaken to study its immune mechanisms in detail, but its unique contribution to steady state cell chemotaxis in upholding immune tolerance and regulating immune homeostasis during inflammation is evident in multiple systems in the human body, including skin, liver, lung, kidney, brain, eye, joints, gonads and the gut...
July 2, 2018: Medicines (Basel, Switzerland)
Jie Yang, Yuan Zhang, Xiaoting Sun, Aaron M Gusdon, Nan Song, Linsong Chen, Gening Jiang, Yueye Huang
PURPOSE: This study aimed to investigate the prognostic value of different organs metastases in patients with non-small cell lung cancer (NSCLC) and its most common subtypes. METHODS: We identified 45,423 NSCLC cases (25,129 men and 20,294 women) between 2010 and 2013 with distant metastases, with complete clinical information obtained from the surveillance, epidemiology, and end results (SEER) database. RESULTS: Bone and liver were the most and the least common metastatic sites with rates of 37...
July 12, 2018: Journal of Cancer Research and Clinical Oncology
Wenting Ni, Wenxing Chen, Yin Lu
Brain metastasis is an important cause of morbidity and mortality in cancer patients. Hence, the need to develop improved therapies to prevent and treat metastasis to the brain is becoming urgent. Recent studies in this area are bringing about some advanced progress on brain metastasis. It was concluded that the occurrence and poor prognosis of brain metastasis have been mostly attributed to the exclusion of anticancer drugs from the brain by the blood-brain barrier. And several highly potent new generation targeted drugs with enhanced CNS distribution have been developed constantly...
July 10, 2018: Cancer Medicine
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