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https://www.readbyqxmd.com/read/30096384/gut-inflammation-exacerbates-hepatic-injury-in-the-high-fat-diet-induced-nafld-mouse-attention-to-the-gut-vascular-barrier-dysfunction
#1
Chunwei Cheng, Jun Tan, Wei Qian, Lei Zhang, Xiaohua Hou
AIMS: Gut inflammation has been put forward to be associated with hepatic injury in the clinical practice. The dismantled intestinal barrier was highly concerned, however, largely unknown about the role of gut-vascular barrier (GVB) in this process. This study aimed to investigate if inflamed gut directly contributes to the progression of non-alcoholic steatohepatitis (NASH), especially attention to the GVB dysfunction. MAIN METHODS: Male C57bl/6 mice were fed with a high-fat diet (HFD) and 1% DSS for 12 weeks...
August 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/30096208/macrophage-cd40-plays-a-minor-role-in-obesity-induced-metabolic-dysfunction
#2
Suzanne A B M Aarts, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Marion J J Gijbels, Norbert Gerdes, Menno P J de Winther, Esther Lutgens
Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced inflammation. Genetic deficiency of CD40L in diet-induced obesity (DIO) ameliorates adipose tissue inflammation, hepatic steatosis and increases insulin sensitivity. Unexpectedly, absence of CD40 worsened insulin resistance and caused excessive adipose tissue inflammation and hepatosteatosis. To investigate whether deficiency of macrophage CD40 is responsible for the phenotype observed in the CD40-/- mice, we generated CD40flflLysMcre and fed them a standard (SFD) and 54% high fat obesogenic diet (HFD) for 13 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/30096029/mortality-due-to-toxoplasmosis-in-suburban-eastern-fox-squirrels-sciurus-niger-in-michigan-usa
#3
Amit Kumar, Julie R Melotti, Thomas M Cooley, Scott D Fitzgerald
Three separate mortality events affecting wild eastern fox squirrels ( Sciurus niger) were investigated in suburban areas within southeastern Michigan over a 3-yr period from the summer of 2015 through the winter of 2017. A total of seven squirrels were submitted for investigation. The squirrels were generally in fair to good body condition with moderate fat deposits. The tissues that most commonly exhibited gross or histologic lesions included the lungs, liver, and heart, whereas spleen and brain exhibited lesions less frequently...
August 10, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/30095558/three-dimensional-high-resolution-black-blood-magnetic-resonance-imaging-for-detection-of-arteritic-anterior-ischemic-optic-neuropathy-in-patients-with-giant-cell-arteritis
#4
Nora N Sommer, Karla M Treitl, Eva Coppenrath, Hendrik Kooijman, Claudia Dechant, Michael Czihal, Theresa M Kolben, Sebastian E Beyer, Wieland H Sommer, Tobias Saam
OBJECTIVES: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION...
August 8, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/30095299/high-fat-diet-overfeeding-promotes-non-detrimental-liver-steatosis-in-female-mice
#5
Lino Arisqueta, Hiart Navarro-Imaz, Ibone Labiano, Yuri Rueda, Olatz Fresnedo
High fat diet (HFD) feeding or leptin deficient mice are extensively used as models resembling features of human non-alcoholic fatty liver disease (NAFLD). The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances. In this work, we characterized the hepatic lipid accumulation induced by HFD in wild type (Wt) and ob/ob mice with the purpose of differentiating adaptations to HFD from those specific of increased overfeeding due to leptin deficiency-associated hyperphagia...
August 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30095298/ground-flaxseed-reverses-protection-of-a-reduced-fat-diet-against-citrobacter-rodentium-induced-colitis
#6
Pekka Määttänen, Eberhard Lurz, Steven R Botts, Richard Y Wu, Chiu William Yeung, Bo Li, Sumayyah Abiff, Kathene C Johnson-Henry, Dion Lepp, Krista A Power, Agostino Pierro, Marc E Surette, Philip M Sherman
Flaxseed is high in omega-3 polyunsaturated fatty acids, fiber and lignans known to lower cholesterol levels. However, its use for prevention or treatment of inflammatory bowel diseases has yielded mixed results, perhaps related to dietary interactions. In this study, we evaluated the impact of ground flaxseed supplementation on the severity of Citrobacter rodentium-induced colitis in the setting of either a high fat (HF; ~36 %kcal) or reduced fat (RF; ~12 %kcal) diet. After weaning, C57BL/6 mice (n=8-15/treatment) were fed ground flaxseed (7g/100g diet) with either HF (HF Flx) or RF (RF Flx) diets for four weeks prior to infection with C...
August 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30095217/programming-of-the-beige-phenotype-in-white-adipose-tissue-of-adult-mice-by-mild-resveratrol-and-nicotinamide-riboside-supplementations-in-early-postnatal-life
#7
Alba Serrano, Madhu Asnani, Ana M Rodríguez, Andreu Palou, Joan Ribot, M Luisa Bonet
SCOPE: Resveratrol (RSV) and nicotinamide riboside (NR) are food compounds with anti-obesity actions in adult rodents. Here we assessed the long-term effects of RSV and NR mild supplementation throughout lactation on adiposity-related parameters and the appearance of the beige phenotype in white adipose tissue (WAT) in adulthood. METHODS AND RESULTS: Newborn mice received orally RSV or NR from day 2 to 20 of life. Control littermates received the vehicle. All animals were weaned onto a chow diet on day 21...
August 10, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/30094970/biomarkers-of-individual-foods-and-separation-of-diets-using-untargeted-lc-ms-based-plasma-metabolomics-in-a-randomized-controlled-trial
#8
Evrim Acar, Gözde Gürdeniz, Bekzod Khakimov, Francesco Savorani, Sanne Kellebjerg Korndal, Thomas Meinert Larsen, Søren Balling Engelsen, Arne Astrup, Lars O Dragsted
SCOPE: Self-reported dietary intake does not represent an objective unbiased assessment. We investigate the effect of the New Nordic Diet (NND) versus Average Danish Diet (ADD) on plasma metabolic profiles to identify biomarkers of compliance and metabolic effects. METHODS AND RESULTS: In a 26-week controlled dietary intervention study, 146 subjects followed either NND, a predominantly organic diet high in fruit, vegetables, whole grains, and fish, or ADD, a diet higher in imported and processed foods...
August 9, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/30094778/transfer-learning-with-deep-convolutional-neural-network-for-liver-steatosis-assessment-in-ultrasound-images
#9
Michał Byra, Grzegorz Styczynski, Cezary Szmigielski, Piotr Kalinowski, Łukasz Michałowski, Rafał Paluszkiewicz, Bogna Ziarkiewicz-Wróblewska, Krzysztof Zieniewicz, Piotr Sobieraj, Andrzej Nowicki
PURPOSE: The nonalcoholic fatty liver disease is the most common liver abnormality. Up to date, liver biopsy is the reference standard for direct liver steatosis quantification in hepatic tissue samples. In this paper we propose a neural network-based approach for nonalcoholic fatty liver disease assessment in ultrasound. METHODS: We used the Inception-ResNet-v2 deep convolutional neural network pre-trained on the ImageNet dataset to extract high-level features in liver B-mode ultrasound image sequences...
August 9, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/30094646/significant-metabolic-improvement-by-a-water-extract-of-olives-animal-and-human-evidence
#10
Nikolaos Peroulis, Vasilis P Androutsopoulos, George Notas, Stella Koinaki, Elsa Giakoumaki, Apostolos Spyros, Εfstathia Manolopoulou, Sophia Kargaki, Maria Tzardi, Eleni Moustou, Euripides G Stephanou, Efstathia Bakogeorgou, Niki Malliaraki, Maria Niniraki, Christos Lionis, Elias Castanas, Marilena Kampa
PURPOSE: Dyslipidemia and impaired glucose metabolism are the main health issues of growing prevalence and significant high healthcare cost, requiring novel prevention and/or therapeutic approaches. Epidemiological and animal studies revealed that olive oil is an important dietary constituent, inducing normolipidemia. However, no studies have specifically investigated the polyphenol-rich water extract of olives (OLWPE), generated during olive oil production. METHODS: In the present work, we initially examined the effect of OLPWE on animals' metabolic parameters...
August 9, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/30094601/high-fat-diet-abolishes-the-cardioprotective-effects-of-ischemic-postconditioning-in-murine-models-despite-increased-thioredoxin-1-levels
#11
Tamara Mazo, Verónica D Annunzio, Tamara Zaobornyj, Virginia Perez, Anabella Gomez, Gabriela Berg, Magali Barchuk, Georgina Ossani, Manuela Martinefski, Valeria Tripodi, Néstor Lago, Ricardo J Gelpi
Ischemic postconditioning (PostC) reduces infarct size in healthy experimental models. However, if protective effects of PostC are abolished during early stages of atherosclerotic and if this is related with a disbalance in mitochondrial energetics and alterations in thioredoxin-1 (Trx1) is still unknown. The objectives were to generate a murine high-fat diet (HFD)-fed model that developed in a phenotype consistent with early stages of atherosclerosis to then evaluate whether HFD exposure increased oxidative stress and consequently abolished the cardioprotection conferred by PostC...
August 9, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/30094122/effects-of-bifidobacterium-breve-b-3-on-body-fat-reductions-in-pre-obese-adults-a-randomized-double-blind-placebo-controlled-trial
#12
Junichi Minami, Noriyuki Iwabuchi, Miyuki Tanaka, Koji Yamauchi, Jin-Zhong Xiao, Fumiaki Abe, Naoki Sakane
Accumulating evidence suggests a relationship between the gut microbiota and the development of obesity, indicating the potential of probiotics as a therapeutic approach. Bifidobacterium breve B-3 has been shown to exert anti-obesity effects in high-fat diet-induced obese mice. In the present study, the anti-obesity effects of the consumption of B. breve B-3 by healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a randomized, double-blind, placebo-controlled trial (trial registration: UMIN-CTR No...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/30093912/switching-from-a-high-fat-cellulose-diet-to-a-high-fat-pectin-diet-reverses-certain-obesity-related-morbidities
#13
Julie K Bray, Gabriel S Chiu, Leslie K McNeil, Morgan L Moon, Robyn Wall, Albert E Towers, Gregory G Freund
Background: Reducing caloric intake is a proven intervention for mitigating and modulating morbidities associated with overnutrition. Caloric restriction is difficult to affect clinically, therefore, dietary interventions that ameliorate the adverse consequences of overnutrition in the presence of a high-calorie diet would be of value. Methods: Mice were fed an obesogenic diet containing 60% fat + 10% cellulose (HFC), or a control diet containing 10% fat + 10% cellulose (LFC) for 12 wks...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/30093356/chronic-d-serine-supplementation-impairs-insulin-secretion
#14
Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S Heinzmann, Eric J C Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H Tschöp, Guy A Rutter, Till Strowig, Martin Elsner, Siegfried Ussar
OBJECTIVE: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to modulate insulin secretion. Thus, we aim to study the impact of chronic and acute d-serine supplementation on insulin secretion and other parameters of glucose homeostasis. METHODS: We apply MALDI FT-ICR mass spectrometry imaging, NMR based metabolomics, 16s rRNA gene sequencing of gut microbiota in combination with a detailed physiological characterization to unravel the metabolic action of d-serine in mice acutely and chronically treated with 1% d-serine in drinking water in combination with either chow or high fat diet feeding...
July 25, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/30093310/a-comparison-of-rodent-models-of-vertical-sleeve-gastrectomy
#15
Rafael Alvarez, Alfor G Lewis, Mouhamadoul H Toure, Randy J Seeley
BACKGROUND: Although vertical sleeve gastrectomy (VSG) is fashioned in humans by applying multiple staple loads, rodent VSG is generally created through a single-staple load application. OBJECTIVES: To investigate the impact of a 2-staple load VSG rat model more closely resembling the multistaple load operation done in humans on weight, metabolic outcomes, and the microbiome and how these compare with those obtained with the standard one-staple load model. SETTING: University research facility, United States...
July 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/30093307/berberine-reduces-pyruvate-driven-hepatic-glucose-production-by-limiting-mitochondrial-import-of-pyruvate-through-mitochondrial-pyruvate-carrier-1
#16
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang
BACKGROUND: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood. This study aims to investigate whether berberine could reduce excessive hepatic glucose production (HGP) by limiting mitochondrial import of pyruvate through MPC1. METHODS: High-fat diet (HFD) feeding augmented HGP. The effects of berberine on hepatic fatty acid oxidation, sirtuin3 (SIRT3) induction and mitochondrial pyruvate carrier 1 (MPC1) function were examined...
August 6, 2018: EBioMedicine
https://www.readbyqxmd.com/read/30093114/anti-obesity-potential-of-glycyrrhiza-uralensis-and-licochalcone-a-through-induction-of-adipocyte-browning
#17
Hye Eun Lee, Gabsik Yang, Sin-Hee Han, Jeong-Hoon Lee, Tae-Jin An, Jae-Ki Jang, Joo Young Lee
The main function of brown adipose tissue is to dissipate surplus caloric intake into heat energy by thermogenesis, increasing energy expenditure. Inducible brown adipocytes can develop within white adipose tissue (WAT) through a process referred to as browning. Browning of white fat represents a promising strategy for treatment of obesity and the related complications. We investigated whether Glycyrrhiza uralensis and its ingredients modulated adipogenesis through adipocyte browning using 3T3-L1 adipocytes and a high-fat diet (HFD)-induced obesity mice model...
August 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30092591/bioactive-peptide-improves-diet-induced-hepatic-fat-deposition-and-hepatocyte-proinflammatory-response-in-samp8-ageing-mice
#18
Stanley Dumeus, Marthandam Asokan Shibu, Wan-Teng Lin, Ming-Fu Wang, Chao-Hung Lai, Chia-Yao Shen, Yueh-Min Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
BACKGROUND/AIMS: High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) poses therapeutic challenges in elderly subjects. Due to lack of efficient drug therapy, plant-based bioactive peptides have been studied as alternative strategy in NAFLD and for less toxicity in elderly. To mimic fatty liver in aging conditions, researchers highly commended the genetically engineered strains SAMP8 (senescence-accelerated mice prone 8). However, there is a paucity of reports about the anti-steatosis effects of bioactive peptides against fatty liver development under a combined action of high-fat diet exposure and aging process...
August 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30092566/aldehyde-dehydrogenase-2-attenuates-myocardial-remodeling-and-contractile-dysfunction-induced-by-a-high-fat-diet
#19
Chuanbao Li, Xiaoxing Li, Ying Chang, Lang Zhao, Baoshan Liu, Shujian Wei, Feng Xu, Yun Zhang, Yuguo Chen
BACKGROUND/AIMS: Consumption of a high-fat (HF) diet exacerbates metabolic cardiomyopathy through lipotoxic mechanisms. In this study, we explored the role of aldehyde dehydrogenase-2 (ALDH2) in myocardial damage induced by a HF diet. METHODS: Wild-type C57 BL/6J mice were fed a HF diet or control diet for 16 weeks. ALDH2 overexpression was achieved by injecting a lentiviral ALDH2 expression vector into the left ventricle. RESULTS: Consumption of a HF diet induced metabolic syndrome and myocardial remodeling, and these deleterious effects were attenuated by ALDH2 overexpression...
August 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30091925/ron-receptor-signaling-ameliorates-hepatic-fibrosis-in-a-diet-induced-non-alcoholic-steatohepatitis-mouse-model
#20
Joselyn Allen, Jingtao Zhang, Michael D Quickel, Mary Kennett, Andrew D Patterson, Pamela A Hankey-Giblin
Liver fibrosis is commonly observed in the terminal stages of non-alcoholic steatohepatitis (NASH) and with no specific and effective anti-fibrotic therapies available, this disease is a major global health burden. The MSP/Ron receptor axis has been shown to have anti-inflammatory properties in a number of mouse models, due at least in part, to its ability to limit pro-inflammatory responses in tissue-resident macrophages and hepatocytes. In this study, we established the role of the Ron receptor in steatohepatitis-induced hepatic fibrosis using Ron ligand domain knockout mice on an apolipoprotein E knockout background (DKO)...
August 9, 2018: Journal of Proteome Research
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