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https://www.readbyqxmd.com/read/30341287/neurokinin-3-receptor-activation-selectively-prolongs-atrial-refractoriness-by-inhibition-of-a-background-k-channel
#1
Marieke W Veldkamp, Guillaume S C Geuzebroek, Antonius Baartscheer, Arie O Verkerk, Cees A Schumacher, Gedeon G Suarez, Wouter R Berger, Simona Casini, Shirley C M van Amersfoorth, Koen T Scholman, Antoine H G Driessen, Charly N W Belterman, Antoni C G van Ginneken, Joris R de Groot, Jacques M T de Bakker, Carol Ann Remme, Bas J Boukens, Ruben Coronel
The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the neurokinins, whose actions on atrial electrophysiology are largely unknown. We here demonstrate that the neurokinin substance-P (Sub-P) activates a neurokinin-3 receptor (NK-3R) in rabbit, prolonging action potential (AP) duration through inhibition of a background potassium current. In contrast, ventricular AP duration was unaffected by NK-3R activation. NK-3R stimulation lengthened atrial repolarization in intact rabbit hearts and consequently suppressed arrhythmia duration and occurrence in a rabbit isolated heart model of atrial fibrillation (AF)...
October 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/30341278/a-functional-genetic-variation-of-slc6a2-repressor-hsa-mir-579-3p-upregulates-sympathetic-noradrenergic-processes-of-fear-and-anxiety
#2
L G Hommers, J Richter, Y Yang, A Raab, C Baumann, K Lang, M A Schiele, H Weber, A Wittmann, C Wolf, G W Alpers, V Arolt, K Domschke, L Fehm, T Fydrich, A Gerlach, A T Gloster, A O Hamm, S Helbig-Lang, T Kircher, T Lang, C A Pané-Farré, P Pauli, B Pfleiderer, A Reif, M Romanos, B Straube, A Ströhle, H-U Wittchen, S Frantz, G Ertl, M J Lohse, U Lueken, J Deckert
Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of microRNAs modulating noradrenaline transporter gene (SLC6A2) expression may thus lead to altered central and peripheral processing of fear and anxiety. In silico prediction of microRNA regulation of SLC6A2 was confirmed by luciferase reporter assays and identified hsa-miR-579-3p as a regulating microRNA. The minor (T)-allele of rs2910931 (MAFcases  = 0...
October 19, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30339647/joint-contact-changes-with-undersized-prosthetic-radial-heads
#3
Daniel R Bachman, Sangeun Park, Sutee Thaveepunsan, James S Fitzsimmons, Kai-Nan An, Shawn W OʼDriscoll
OBJECTIVE: To evaluate the effect of intentional undersizing of prosthetic radial head implant diameters on joint contact pressures. METHODS: Eight fresh-frozen cadaveric elbows were aligned in neutral extension and loaded with 100 N using a custom testing apparatus. Radiocapitellar contact pressures were recorded using a Tekscan thin-film pressure sensor. Prosthetic radial head replacement was performed with 2 prostheses: the Anatomic Radial Head and the Evolve Proline Radial Head prostheses...
November 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/30339445/oxygen-electromigration-and-energy-band-reconstruction-induced-by-electrolyte-field-effect-at-oxide-interfaces
#4
S W Zeng, X M Yin, T S Herng, K Han, Z Huang, L C Zhang, C J Li, W X Zhou, D Y Wan, P Yang, J Ding, A T S Wee, J M D Coey, T Venkatesan, A Rusydi, A Ariando
Electrolyte gating is a powerful means for tuning the carrier density and exploring the resultant modulation of novel properties on solid surfaces. However, the mechanism, especially its effect on the oxygen migration and electrostatic charging at the oxide heterostructures, is still unclear. Here we explore the electrolyte gating on oxygen-deficient interfaces between SrTiO_{3} (STO) crystals and LaAlO_{3} (LAO) overlayer through the measurements of electrical transport, x-ray absorption spectroscopy, and photoluminescence spectra...
October 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30339442/search-for-pair-produced-resonances-each-decaying-into-at-least-four-quarks-in-proton-proton-collisions-at-sqrt-s-13-tev
#5
A M Sirunyan, A Tumasyan, W Adam, F Ambrogi, E Asilar, T Bergauer, J Brandstetter, M Dragicevic, J Erö, A Escalante Del Valle, M Flechl, R Frühwirth, V M Ghete, J Hrubec, M Jeitler, N Krammer, I Krätschmer, D Liko, T Madlener, I Mikulec, N Rad, H Rohringer, J Schieck, R Schöfbeck, M Spanring, D Spitzbart, A Taurok, W Waltenberger, J Wittmann, C-E Wulz, M Zarucki, V Chekhovsky, V Mossolov, J Suarez Gonzalez, E A De Wolf, D Di Croce, X Janssen, J Lauwers, M Pieters, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, S Abu Zeid, F Blekman, J D'Hondt, I De Bruyn, J De Clercq, K Deroover, G Flouris, D Lontkovskyi, S Lowette, I Marchesini, S Moortgat, L Moreels, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, D Beghin, B Bilin, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, B Dorney, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, A K Kalsi, T Lenzi, J Luetic, N Postiau, E Starling, L Thomas, C Vander Velde, P Vanlaer, D Vannerom, Q Wang, T Cornelis, D Dobur, A Fagot, M Gul, I Khvastunov, D Poyraz, C Roskas, D Trocino, M Tytgat, W Verbeke, B Vermassen, M Vit, N Zaganidis, H Bakhshiansohi, O Bondu, S Brochet, G Bruno, C Caputo, P David, C Delaere, M Delcourt, B Francois, A Giammanco, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, K Piotrzkowski, A Saggio, M Vidal Marono, S Wertz, J Zobec, F L Alves, G A Alves, L Brito, M Correa Martins Junior, G Correia Silva, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, E Coelho, E M Da Costa, G G Da Silveira, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, H Malbouisson, D Matos Figueiredo, M Melo De Almeida, C Mora Herrera, L Mundim, H Nogima, W L Prado Da Silva, L J Sanchez Rosas, A Santoro, A Sznajder, M Thiel, E J Tonelli Manganote, F Torres Da Silva De Araujo, A Vilela Pereira, S Ahuja, C A Bernardes, L Calligaris, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, S F Novaes, Sandra S Padula, D Romero Abad, A Aleksandrov, R Hadjiiska, P Iaydjiev, A Marinov, M Misheva, M Rodozov, M Shopova, G Sultanov, A Dimitrov, L Litov, B Pavlov, P Petkov, W Fang, X Gao, L Yuan, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, C H Jiang, D Leggat, H Liao, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, E Yazgan, H Zhang, J Zhao, Y Ban, G Chen, A Levin, J Li, L Li, Q Li, Y Mao, S J Qian, D Wang, Z Xu, Y Wang, C Avila, A Cabrera, C A Carrillo Montoya, L F Chaparro Sierra, C Florez, C F González Hernández, M A Segura Delgado, B Courbon, N Godinovic, D Lelas, I Puljak, T Sculac, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, B Mesic, A Starodumov, T Susa, M W Ather, A Attikis, M Kolosova, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Finger, M Finger, E Ayala, E Carrera Jarrin, Y Assran, S Elgammal, Y Mohammed, S Bhowmik, A Carvalho Antunes De Oliveira, R K Dewanjee, K Ehataht, M Kadastik, M Raidal, C Veelken, P Eerola, H Kirschenmann, J Pekkanen, M Voutilainen, J Havukainen, J K Heikkilä, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Laurila, S Lehti, T Lindén, P Luukka, T Mäenpää, H Siikonen, E Tuominen, J Tuominiemi, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, J L Faure, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, C Leloup, E Locci, J Malcles, G Negro, J Rander, A Rosowsky, M Ö Sahin, M Titov, A Abdulsalam, C Amendola, I Antropov, F Beaudette, P Busson, C Charlot, R Granier de Cassagnac, I Kucher, S Lisniak, A Lobanov, J Martin Blanco, M Nguyen, C Ochando, G Ortona, P Pigard, R Salerno, J B Sauvan, Y Sirois, A G Stahl Leiton, A Zabi, A Zghiche, J-L Agram, J Andrea, D Bloch, J-M Brom, E C Chabert, V Cherepanov, C Collard, E Conte, J-C Fontaine, D Gelé, U Goerlach, M Jansová, A-C Le Bihan, N Tonon, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, N Chanon, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fay, L Finco, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, H Lattaud, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, V Sordini, M Vander Donckt, S Viret, S Zhang, T Toriashvili, Z Tsamalaidze, C Autermann, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, M P Rauch, C Schomakers, J Schulz, M Teroerde, B Wittmer, V Zhukov, A Albert, D Duchardt, M Endres, M Erdmann, T Esch, R Fischer, S Ghosh, A Güth, T Hebbeker, C Heidemann, K Hoepfner, H Keller, S Knutzen, L Mastrolorenzo, M Merschmeyer, A Meyer, P Millet, S Mukherjee, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, A Schmidt, D Teyssier, G Flügge, O Hlushchenko, B Kargoll, T Kress, A Künsken, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, H Sert, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, I Babounikau, K Beernaert, O Behnke, U Behrens, A Bermúdez Martínez, D Bertsche, A A Bin Anuar, K Borras, V Botta, A Campbell, P Connor, C Contreras-Campana, F Costanza, V Danilov, A De Wit, M M Defranchis, C Diez Pardos, D Domínguez Damiani, G Eckerlin, T Eichhorn, A Elwood, E Eren, E Gallo, A Geiser, J M Grados Luyando, A Grohsjean, P Gunnellini, M Guthoff, M Haranko, A Harb, J Hauk, H Jung, M Kasemann, J Keaveney, C Kleinwort, J Knolle, D Krücker, W Lange, A Lelek, T Lenz, K Lipka, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, M Meyer, M Missiroli, G Mittag, J Mnich, V Myronenko, S K Pflitsch, D Pitzl, A Raspereza, M Savitskyi, P Saxena, P Schütze, C Schwanenberger, R Shevchenko, A Singh, N Stefaniuk, H Tholen, O Turkot, A Vagnerini, G P Van Onsem, R Walsh, Y Wen, K Wichmann, C Wissing, O Zenaiev, R Aggleton, S Bein, L Benato, A Benecke, V Blobel, M Centis Vignali, T Dreyer, E Garutti, D Gonzalez, J Haller, A Hinzmann, A Karavdina, G Kasieczka, R Klanner, R Kogler, N Kovalchuk, S Kurz, V Kutzner, J Lange, D Marconi, J Multhaup, M Niedziela, D Nowatschin, A Perieanu, A Reimers, O Rieger, C Scharf, P Schleper, S Schumann, J Schwandt, J Sonneveld, H Stadie, G Steinbrück, F M Stober, M Stöver, D Troendle, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, M Baselga, S Baur, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, N Faltermann, B Freund, M Giffels, M A Harrendorf, F Hartmann, S M Heindl, U Husemann, F Kassel, I Katkov, S Kudella, H Mildner, S Mitra, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, A Kyriakis, D Loukas, G Paspalaki, I Topsis-Giotis, G Karathanasis, S Kesisoglou, P Kontaxakis, A Panagiotou, N Saoulidou, E Tziaferi, K Vellidis, K Kousouris, I Papakrivopoulos, G Tsipolitis, I Evangelou, C Foudas, P Gianneios, P Katsoulis, P Kokkas, S Mallios, N Manthos, I Papadopoulos, E Paradas, J Strologas, F A Triantis, D Tsitsonis, M Bartók, M Csanad, N Filipovic, P Major, M I Nagy, G Pasztor, O Surányi, G I Veres, G Bencze, C Hajdu, D Horvath, Á Hunyadi, F Sikler, T Á Vámi, V Veszpremi, G Vesztergombi, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, P Raics, Z L Trocsanyi, B Ujvari, S Choudhury, J R Komaragiri, P C Tiwari, S Bahinipati, C Kar, P Mal, K Mandal, A Nayak, D K Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, S Chauhan, R Chawla, N Dhingra, R Gupta, A Kaur, A Kaur, M Kaur, S Kaur, R Kumar, P Kumari, M Lohan, A Mehta, K Sandeep, S Sharma, J B Singh, G Walia, A Bhardwaj, B C Choudhary, R B Garg, M Gola, S Keshri, Ashok Kumar, S Malhotra, M Naimuddin, P Priyanka, K Ranjan, Aashaq Shah, R Sharma, R Bhardwaj, M Bharti, R Bhattacharya, S Bhattacharya, U Bhawandeep, D Bhowmik, S Dey, S Dutt, S Dutta, S Ghosh, K Mondal, S Nandan, A Purohit, P K Rout, A Roy, S Roy Chowdhury, S Sarkar, M Sharan, B Singh, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, P K Netrakanti, L M Pant, P Shukla, T Aziz, M A Bhat, S Dugad, G B Mohanty, N Sur, B Sutar, R Kumar Verma, S Banerjee, S Bhattacharya, S Chatterjee, P Das, M Guchait, Sa Jain, S Karmakar, S Kumar, M Maity, G Majumder, K Mazumdar, N Sahoo, T Sarkar, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, M Khakzad, M Mohammadi Najafabadi, M Naseri, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, A Di Florio, F Errico, L Fiore, A Gelmi, G Iaselli, M Ince, S Lezki, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Zito, G Abbiendi, C Battilana, D Bonacorsi, L Borgonovi, S Braibant-Giacomelli, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, C Ciocca, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, P Giacomelli, C Grandi, L Guiducci, F Iemmi, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, F Primavera, A M Rossi, T Rovelli, G P Siroli, N Tosi, S Albergo, A Di Mattia, R Potenza, A Tricomi, C Tuve, G Barbagli, K Chatterjee, V Ciulli, C Civinini, R D'Alessandro, E Focardi, G Latino, P Lenzi, M Meschini, S Paoletti, L Russo, G Sguazzoni, D Strom, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Ferro, F Ravera, E Robutti, S Tosi, A Benaglia, A Beschi, L Brianza, F Brivio, V Ciriolo, S Di Guida, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, A Massironi, D Menasce, L Moroni, M Paganoni, D Pedrini, S Ragazzi, T Tabarelli de Fatis, S Buontempo, N Cavallo, A Di Crescenzo, F Fabozzi, F Fienga, G Galati, A O M Iorio, W A Khan, L Lista, S Meola, P Paolucci, C Sciacca, E Voevodina, P Azzi, N Bacchetta, D Bisello, A Boletti, A Bragagnolo, R Carlin, P Checchia, M Dall'Osso, P De Castro Manzano, T Dorigo, U Dosselli, F Gasparini, F Gonella, A Gozzelino, S Lacaprara, P Lujan, M Margoni, A T Meneguzzo, J Pazzini, N Pozzobon, P Ronchese, R Rossin, A Tiko, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, M Ressegotti, C Riccardi, P Salvini, I Vai, P Vitulo, L Alunni Solestizi, M Biasini, G M Bilei, C Cecchi, D Ciangottini, L Fanò, P Lariccia, R Leonardi, E Manoni, G Mantovani, V Mariani, M Menichelli, A Rossi, A Santocchia, D Spiga, K Androsov, P Azzurri, G Bagliesi, L Bianchini, T Boccali, L Borrello, R Castaldi, M A Ciocci, R Dell'Orso, G Fedi, F Fiori, L Giannini, A Giassi, M T Grippo, F Ligabue, E Manca, G Mandorli, A Messineo, F Palla, A Rizzi, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, N Daci, D Del Re, E Di Marco, M Diemoz, S Gelli, E Longo, B Marzocchi, P Meridiani, G Organtini, F Pandolfi, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, F Cenna, S Cometti, M Costa, R Covarelli, N Demaria, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, D Soldi, A Staiano, S Belforte, V Candelise, M Casarsa, F Cossutti, G Della Ricca, F Vazzoler, A Zanetti, D H Kim, G N Kim, M S Kim, J Lee, S Lee, S W Lee, C S Moon, Y D Oh, S Sekmen, D C Son, Y C Yang, H Kim, D H Moon, G Oh, J Goh, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, H S Kim, J Almond, J Kim, J S Kim, H Lee, K Lee, K Nam, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, D Jeon, H Kim, J H Kim, J S H Lee, I C Park, Y Choi, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, A Castaneda Hernandez, J A Murillo Quijada, M C Duran-Osuna, H Castilla-Valdez, E De La Cruz-Burelo, G Ramirez-Sanchez, I Heredia-De La Cruz, R I Rabadan-Trejo, R Lopez-Fernandez, J Mejia Guisao, R Reyes-Almanza, M Ramirez-Garcia, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, J Eysermans, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, S Bheesette, P H Butler, A Ahmad, M Ahmad, M I Asghar, Q Hassan, H R Hoorani, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, M Szleper, P Traczyk, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, A Pyskir, M Walczak, P Bargassa, C Beirão Da Cruz E Silva, A Di Francesco, P Faccioli, B Galinhas, M Gallinaro, J Hollar, N Leonardo, L Lloret Iglesias, M V Nemallapudi, J Seixas, G Strong, O Toldaiev, D Vadruccio, J Varela, V Alexakhin, A Golunov, I Golutvin, N Gorbounov, I Gorbunov, A Kamenev, V Karjavin, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, M Savina, S Shmatov, S Shulha, N Skatchkov, V Smirnov, A Zarubin, V Golovtsov, Y Ivanov, V Kim, E Kuznetsova, P Levchenko, V Murzin, V Oreshkin, I Smirnov, D Sosnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, I Pozdnyakov, G Safronov, A Spiridonov, A Stepennov, V Stolin, M Toms, E Vlasov, A Zhokin, T Aushev, R Chistov, M Danilov, P Parygin, D Philippov, S Polikarpov, E Tarkovskii, V Andreev, M Azarkin, I Dremin, M Kirakosyan, S V Rusakov, A Terkulov, A Baskakov, A Belyaev, E Boos, V Bunichev, M Dubinin, L Dudko, A Ershov, A Gribushin, V Klyukhin, O Kodolova, I Lokhtin, I Miagkov, S Obraztsov, S Petrushanko, V Savrin, V Blinov, T Dimova, L Kardapoltsev, D Shtol, Y Skovpen, I Azhgirey, I Bayshev, S Bitioukov, D Elumakhov, A Godizov, V Kachanov, A Kalinin, D Konstantinov, P Mandrik, V Petrov, R Ryutin, S Slabospitskii, A Sobol, S Troshin, N Tyurin, A Uzunian, A Volkov, A Babaev, S Baidali, P Adzic, P Cirkovic, D 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Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, T Ruggles, A Savin, N Smith, W H Smith, N Woods
This Letter presents the results of a search for pair-produced particles of masses above 100 GeV that each decay into at least four quarks. Using data collected by the CMS experiment at the LHC in 2015-2016, corresponding to an integrated luminosity of 38.2  fb^{-1}, reconstructed particles are clustered into two large jets of similar mass, each consistent with four-parton substructure. No statistically significant excess of data over the background prediction is observed in the distribution of average jet mass...
October 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30339440/observation-of-the-z%C3%A2-%C3%AF-%C3%A2-%C3%A2-decay-in-pp-collisions-at-sqrt-s-13-tev
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Pena, O Prokofyev, G Rakness, L Ristori, A Savoy-Navarro, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, L Cadamuro, A Carnes, M Carver, D Curry, R D Field, S V Gleyzer, B M Joshi, J Konigsberg, A Korytov, P Ma, K Matchev, H Mei, G Mitselmakher, K Shi, D Sperka, J Wang, S Wang, Y R Joshi, S Linn, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, A Santra, V Sharma, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, M Rahmani, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, S Dittmer, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, C Mills, I D Sandoval Gonzalez, M B Tonjes, N Varelas, H Wang, X Wang, Z Wu, J Zhang, M Alhusseini, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, W T Hung, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, A Bylinkin, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Rogan, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, D Kim, Y Maravin, D R Mendis, T Mitchell, A Modak, A Mohammadi, L K Saini, N Skhirtladze, F Rebassoo, D Wright, A Baden, O Baron, A Belloni, S C Eno, Y Feng, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, K Wong, D Abercrombie, B Allen, V Azzolini, A Baty, G Bauer, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, P Harris, D Hsu, M Hu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y-J Lee, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, G S F Stephans, K Sumorok, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, S Zhaozhong, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, S Kalafut, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, J Turkewitz, M A Wadud, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, F Golf, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, A Godshalk, C Harrington, I Iashvili, A Kharchilava, D Nguyen, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, C Freer, A Hortiangtham, D M Morse, T Orimoto, R Teixeira De Lima, T Wamorkar, B Wang, A Wisecarver, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, M H Schmitt, K Sung, M Trovato, M Velasco, R Bucci, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, W Li, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, P Siddireddy, G Smith, S Taroni, M Wayne, A Wightman, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, T Y Ling, W Luo, B L Winer, H W Wulsin, S Cooperstein, P Elmer, J Hardenbrook, P Hebda, S Higginbotham, A Kalogeropoulos, D Lange, M T Lucchini, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, J Salfeld-Nebgen, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, S Das, L Gutay, M Jones, A W Jung, A Khatiwada, B Mahakud, D H Miller, N Neumeister, C C Peng, H Qiu, J F Schulte, J Sun, F Wang, R Xiao, W Xie, T Cheng, J Dolen, N Parashar, Z Chen, K M Ecklund, S Freed, F J M Geurts, M Kilpatrick, W Li, B Michlin, B P Padley, J Roberts, J Rorie, W Shi, Z Tu, J Zabel, A Zhang, A Bodek, P de Barbaro, R Demina, Y T Duh, J L Dulemba, C Fallon, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, R Taus, M Verzetti, A Agapitos, J P Chou, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Castaneda Hernandez, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, S Luo, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Safonov, A Tatarinov, N Akchurin, J Damgov, F De Guio, P R Dudero, S Kunori, K Lamichhane, S W Lee, T Mengke, S Muthumuni, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, J D Ruiz Alvarez, P Sheldon, S Tuo, J Velkovska, M Verweij, Q Xu, M W Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, T Ruggles, A Savin, N Smith, W H Smith, N Woods
This Letter presents the observation of the rare Z boson decay Z→ψℓ^{+}ℓ^{-}. Here, ψ represents contributions from direct J/ψ and ψ(2S)→J/ψX, ℓ^{+}ℓ^{-} is a pair of electrons or muons, and the J/ψ meson is detected via its decay to μ^{+}μ^{-}. The sample of proton-proton collision data, collected by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, corresponds to an integrated luminosity of 35.9  fb^{-1}. The signal is observed with a significance in excess of 5 standard deviations...
October 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30338834/-fourth-universal-definition-of-myocardial-infarction-2018
#7
Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Bernard R Chaitman, Jeroen J Bax, David A Morrow, Harvey D White, Hans Mickley, Filippo Crea, Frans Van de Werf, Chiara Bucciarelli-Ducci, Hugo A Katus, Fausto J Pinto, Elliott M Antman, Christian W Hamm, Rafelle De Caterina, James L Januzzi, Fred S Apple, Maria Angeles Alonso Garcia, S Richard Underwood, John M Canty, Alexander R Lyon, P J Devereaux, Jose Lusi Zamorano, Bertil Lindahl, William S Weintraub, L Kristin Newby, Renu Virmani, Pascal Vranckx, Don Cutlip, Raymond J Gibbons, Sidney C Smith, Dan Atar, Russell V Luepker, Rose Marie Robertson, Robert O Bonow, P Gabriel Steg, Patrick T O'Gara, Keith A A Fox
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/30338798/mir-425-involves-in-the-development-and-progression-of-renal-cell-carcinoma-by-inhibiting-e2f6
#8
Q Cai, A Zhao, L-G Ren, J Chen, K-S Liao, Z-S Wang, W Zhang
OBJECTIVE: To investigate the effect of miR-425 on the proliferation and apoptosis of clear cell renal carcinoma (ccRCA) cells, and to explore the underlying mechanism. PATIENTS AND METHODS: A total of 80 pairs of human clear cell renal carcinoma (ccRCA) and cancer-adjacent normal tissue samples were collected in this study. Human ccRCA cell line (786-O) and normal human kidney cell line (HK-2) were used in cellular research. The expression level of miR-425 was detected in ccRCA tissues and cells, respectively...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30338705/lactoferrin-tagged-quantum-dots-based-theranostic-nanocapsules-for-combined-cox-2-inhibitor-herbal-therapy-of-breast-cancer
#9
Ahmed S AbdElhamid, Dina G Zayed, Maged W Helmy, Shaker M Ebrahim, Mohammed Bahey-El-Din, Esmat A Zein-El-Dein, Sanaa A El-Gizawy, Ahmed O Elzoghby
AIM: Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate and cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) were sequentially assembled onto the surface of the positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs were coupled to LF. RESULTS: In vitro, fluorescence of QDs was quenched (OFF state) due to combined electron/energy transfer-mediated processes involving LF...
October 19, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30338337/epidural-needle-insertion-a-large-registry-analysis
#10
H Bomberg, N Paquet, A Huth, S Wagenpfeil, P Kessler, H Wulf, T Wiesmann, T Standl, A Gottschalk, J Döffert, W Hering, J Birnbaum, B Kutter, J Winckelmann, S Liebl-Biereige, W Meissner, O Vicent, T Koch, H Bürkle, D I Sessler, A Raddatz, T Volk
BACKGROUND: Dural puncture, paraesthesia and vascular puncture are the most common complications of epidural catheter insertion. Their association with variation in midline needle insertion depth is unknown. OBJECTIVE: This study evaluated the risk of dural and vascular punctures and the unwanted events paraesthesia and multiple skin punctures related to midline needle insertion depth. MATERIAL AND METHODS: A total of 14,503 epidural catheter insertions including lumbar (L1-L5; n = 5367), low thoracic (T7-T12, n = 8234) and upper thoracic (T1-T6, n = 902) insertions, were extracted from the German Network for Regional Anaesthesia registry between 2007 and 2015...
October 18, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/30337735/-chloroquine-inhibits-viability-of-renal-carcinoma-cells-and-enhances-sunitinib-induced-caspase-dependent-apoptosis
#11
J Sun, W D Song, S Y Yan, Z J Xi
OBJECTIVE: To determine whether chloroquine (CQ), an often used inhibitor of late autophagy and autophagosome/lyosome fusion, can inhibit proliferation of renal carcinoma cells and investigate its effect on sunitinib (ST)-induced apoptosis. METHODS: Renal carcinoma cell line 786 O and ACHN had been used as cellular model and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay was carried out to detect the cell viability in response to CQ or ST treatment...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/30337435/outcomes-of-stent-retriever-versus-aspiration-first-thrombectomy-in-ischemic-stroke-a-systematic-review-and-meta-analysis
#12
C O A Tsang, I H W Cheung, K K Lau, W Brinjikji, D F Kallmes, T Krings
BACKGROUND: There is ongoing debate regarding the optimal first-line thrombectomy technique for large-vessel occlusion. PURPOSE: We performed a systematic review and meta-analysis of comparative studies on stent retriever-first and aspiration-first thrombectomy. DATA SOURCES: We searched Ovid MEDLINE, PubMed, and EMBASE from 2009 to February 2018. STUDY SELECTION: Two reviewers independently selected the studies. The primary end point was successful reperfusion (TICI 2b/3)...
October 18, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/30336769/efficacy-of-combined-regional-inductive-moderate-hyperthermia-and-chemotherapy-in-patients-with-multiple-liver-metastases-from-breast-cancer
#13
Mykhailo Yu Klimanov, Liubov A Syvak, Valerii E Orel, G V Lavryk, Tetiana Ye Tarasenko, Valerii B Orel, Alex Yu Rykhalskyi, Viadysiav V Stegnii, Andrii O Nesterenko
PURPOSE: Regional inductive moderate hyperthermia in combination with chemotherapy can improve the therapeutic efficacy in patients with breast cancer with multiple liver metastases. METHODS: The study included 103 patients with breast cancer with multiple liver metastases: 53 patients (main group) who received a combined chemotherapy (TC drug combination) and regional inductive moderate hyperthermia treatment and 50 patients (control group) who received chemotherapy (TC drug combination) alone...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/30336593/physicochemical-characterization-of-fret-labelled-chitosan-nanocapsules-and-model-degradation-studies
#14
Stefan Hoffmann, Christian Gorzelanny, Bruno Moerschbacher, Francisco M Goycoolea
Sub-micron o/w emulsions coated with chitosan have been used for drug delivery, quorum sensing inhibition, and vaccine development. To study interactions with biological systems, nanocapsules have been fluorescently labelled in previous works, but it is often difficult to distinguish the released label from intact nanocapsules. In this study, we present advanced-labelling strategies based on Förster Resonance Energy Transfer (FRET) measurements for chitosan-coated nanocapsules and investigate their dissolution and degradation...
October 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30336238/microencapsulation-of-microbial-canthaxanthin-with-alginate-and-high-methoxyl-pectin-and-evaluation-the-release-properties-in-neutral-and-acidic-condition
#15
Masoumeh Arab, Seyede Marzieh Hosseini, Kooshan Nayebzadeh, Nasim Khorshidian, Mojtaba Yousefi, Seyed Hadi Razavi, Amir Mohammad Mortazavian
Canthaxanthin (CX) is an orange-red keto-carotenoid with high antioxidant activity. This functional pigment is sensitive to oxygen, light, pH and heat. In this study, CX was produced by the Dietzia natronolimnaea HS-1 and was encapsulated in Alginate (Alg) and Alg-high methoxyl pectin (HMP) through O/W/O multiple emulsion/external gelation method to developed resistant microparticles among acidic and neutral pHs. Results showed that initial CX concentration had a significant influence on total CX (TCX), surface CX (SCX), microencapsulation efficiency (EE) and particles size...
October 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30335993/leaving-groups-as-traceless-topological-modifiers-for-the-synthesis-of-topologically-isomeric-polymer-networks
#16
Yuwei Gu, Dominik Schauenburg, Jeffrey W Bode, Jeremiah A Johnson
The chemical and topological structure of polymer networks can seldom be orthogonally controlled. For example, novel network topologies are often accessed via the direct incorporation of supramolecular assemblies into the network structure, introducing potentially undesirable chemical components. Here, we address this deficiency by programming topology into network precursors through the incorporation of self-assembly motifs in leaving groups, which become "traceless topological modifiers." Our method enables us to control polymer network topology using self-assembled structures as templates that are not themselves incorporated into the network...
October 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30335984/resonance-raman-epr-and-mcd-spectroscopic-investigation-of-diheme-cytochrome-c-peroxidases-from-nitrosomonas-europaea-and-shewanella-oneidensis
#17
Matthew W Wolf, Kimberly Rizzolo, Sean J Elliott, Nicolai Lehnert
Cytochrome c peroxidases (bCcPs) are diheme enzymes required for the reduction of H2O2 to water in bacteria. There are two classes of bCcPs: one class of enzymes is active in the diferric form (constitutively active), and the other class of enzymes requires the reduction of the high-potential heme (H-heme) before catalysis commences (reductively activated) at the lowpotential heme (L-heme). In order to better understand the mechanisms and heme electronic structures of these different bCcPs, a constitutively active bCcP from Nitrosomonas europaea (NeCcP) and a reductively activated bCcP from Shewanella oneidensis (SoCcP) were characterized in both the diferric and semi-reduced states by electron paramagnetic resonance (EPR), resonance Raman (rRaman), and magnetic circular dichroism (MCD) spectroscopy...
October 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/30335677/greater-odds-for-angina-in-uranium-miners-than-non-uranium-miners-in-new-mexico
#18
Vanessa J M Al Rashida, Xin Wang, Orrin B Myers, Tawny W Boyce, Elizabeth Kocher, Megan Moreno, Roger Karr, Nour Assad, Linda S Cook, Akshay Sood
OBJECTIVE: To test the hypothesis that uranium miners in New Mexico (NM) have a greater prevalence of cardiovascular disease than miners who extracted non-uranium ore. METHODS: NM-based current and former uranium miners were compared to non-uranium miners by using cross-sectional standardized questionnaire data from the Mining Dust in the United States (MiDUS) study from 1989 to 2016. RESULTS: Of the 7,215 eligible miners, most were men (96...
October 17, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/30335145/genome-sequence-of-the-wheat-stem-sawfly-cephus-cinctus-representing-an-early-branching-lineage-of-the-hymenoptera-illuminates-evolution-of-hymenopteran-chemoreceptors
#19
Hugh M Robertson, Robert M Waterhouse, Kimberly K O Walden, Livio Ruzzante, Maarten J M F Reijnders, Brad S Coates, Fabrice Legeai, Joanna C Gress, Sezgi Biyiklioglu, David K Weaver, Kevin W Wanner, Hikmet Budak
The wheat stem sawfly, Cephus cinctus, is a major pest of wheat and key ecological player in the grasslands of western North America. It also represents the distinctive Cephoidea superfamily of sawflies (Symphyta) that appeared early during the hymenopteran radiation, but after three early-branching eusymphytan superfamilies that form the base of the order Hymenoptera. We present a high-quality draft genome assembly of 162 Mbp in 1,976 scaffolds with a scaffold N50 of 622 kbp. Automated gene annotation identified 11,210 protein-coding gene models and 1,307 non-coding RNA models...
October 18, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/30334632/identification-of-acute-kidney-injury-sub-phenotypes-with-differing-molecular-signatures-and-response-to-vasopressin-therapy
#20
Pavan K Bhatraju, Leila R Zelnick, Jerald Herting, Ronit Katz, Carmen Mikacenic, Susanna Kosamo, Eric D Morrell, Cassianne Robinson-Cohen, Carolyn S Calfee, Jason D Christie, Kathleen D Liu, Michael A Matthay, William O Hahn, Victoria Dmyterko, Natalie S J Slivinski, Jim A Russell, Keith R Walley, David C Christiani, W Conrad Liles, Jonathan Himmelfarb, Mark M Wurfel
OBJECTIVE: The aim of this study was to identify and test whether AKI sub-phenotypes have prognostic and therapeutic implications. METHODS: First, latent class analysis methodology was applied independently in two critically ill populations (Discovery: n=794 and Replication: n=425) with AKI. Second, a parsimonious classification model was developed to identify AKI sub-phenotypes. Third, the classification model was applied to patients with AKI in the Vasopressin in Septic Shock (VASST: n=271) clinical trial and differences in treatment response were determined...
October 18, 2018: American Journal of Respiratory and Critical Care Medicine
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