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https://www.readbyqxmd.com/read/28635261/novel-protein-based-solid-biosensor-for-determining-pro-oxidant-activity-of-phenolic-compounds
#1
Esin Akyüz, Kevser Sözgen Başkan, Esma Tütem, Reşat Apak
To develop a protein‒based biosensor measuring the pro-oxidant activities of phenolic compounds, egg white proteins were precipitated with calcium chloride to obtain an insoluble calcium proteinate complex. This biosensor was used for the determination of Cu(II)‒induced pro-oxidant activity of antioxidants such as gallic acid, catechin, epicatechin, quercetin, chlorogenic acid and myricetin, and ascorbic acid. This assay involved the reduction of Cu(II) ions to Cu(I) by antioxidant compounds (simultaneously giving rise to reactive oxygen species) and binding of the formed Cu(I) to the solid biosensor...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28629861/flavonoids-determine-the-rate-of-fibrillogenesis-and-structure-of-collagen-type-i-fibrils-in-vitro
#2
Yuri A Kim, Yury S Tarahovsky, Sergei G Gaidin, Elena A Yagolnik, Eugeny N Muzafarov
Collagen fibrils are produced from collagen monomers not only in vivo, but also in vitro. The ability to have an influence on the structure and properties of fibrils may find medical application and can be useful for controlling the formation of collagen gels and sheets in tissue engineering. Here we investigated the influence of flavonoids, distinguished by the number of hydroxyl groups in the B-ring, on the formation of collagen fibrils. A correlation was found between the number of hydroxyl groups, lipophilicity of molecules and their ability to influence the fibril formation...
June 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28620169/structural-insight-for-the-recognition-of-g-quadruplex-structure-at-human-c-myc-promoter-sequence-by-flavonoid-quercetin
#3
Arpita Tawani, Subodh Kumar Mishra, Amit Kumar
Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known for their various promising effects on human health. In present study, we have performed detailed biophysical studies for the interaction of human c-myc G-quadruplex DNA with nine representative flavonoids: Luteolin, Quercetin, Rutin, Genistein, Kaempferol, Puerarin, Hesperidin, Myricetin and Daidzein...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619513/myricetin-ameliorates-scopolamine-induced-memory-impairment-in-mice-via-inhibiting-acetylcholinesterase-and-down-regulating-brain-iron
#4
Beiyun Wang, Yuan Zhong, Chengjie Gao, Jingbo Li
The aim of our study was to investigate to investigate the effect of myricetin on Alzheimer's disease (AD) and its underlying mechanisms. In our study, Myricetin effectively attenuated Fe(2+)-induced cell death in SH-SY5Y cells in vitro. In a mouse model of AD, myricetin treatment significantly reversed scopolamine-induced cognitive deficits deriving from a novel action of inhibiting acetylcholinesterase (AChE) and down-regulating brain iron. Furthermore, Myricetin treatment reduced oxidative damage and increased antioxidant enzymes activity in mice...
June 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28588737/myricetin-induces-apoptosis-and-enhances-chemosensitivity-in-ovarian-cancer-cells
#5
Ai-Wen Zheng, Ya-Qing Chen, Ling-Qin Zhao, Jian-Guo Feng
Ovarian cancer is the most lethal type of gynecological cancer and is the fifth leading cause of cancer-associated mortality in females globally. The majority of patients with ovarian cancer suffer from recurrent, progressive disease, due to the acquisition of a resistance phenotype towards various conventional chemotherapy drugs. Although paclitaxel has been demonstrated to be effective against ovarian tumors, there have been reports of the development of a resistant phenotype against Taxol(®) treatment. The multidrug resistance (MDR)-1/P-glycoprotein has previously been demonstrated to be associated with the acquisition of paclitaxel resistance in certain ovarian tumors...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588273/myricetin-protects-galleria-mellonella-against-staphylococcus-aureus-infection-and-inhibits-multiple-virulence-factors
#6
L N Silva, G C A Da Hora, T A Soares, M S Bojer, H Ingmer, A J Macedo, D S Trentin
Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. Myricetin affects both surface proteins and secreted proteins which indicate that its action is unrelated to inhibition of the agr quorum sensing system...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585244/characterization-of-phenolic-composition-in-carignan-noir-grapes-vitis-vinifera-l-from-six-wine-growing-sites-in-maule-valley-chile
#7
Ana M Martínez-Gil, Gastón Gutiérrez-Gamboa, Teresa Garde-Cerdán, Eva P Pérez-Álvarez, Yerko Moreno-Simunovic
BACKGROUND: Among Chilean varieties, Carignan noir has had a major resurgence due to its rediscovered wine quality potential. For this, the aim of this study was to characterize phenolic composition of grapes grown in six sites from the Maule Valley. RESULTS: The data showed that myricetin-3-glc and catechin were the most important flavonol and flavanol respectively. Anthocyanin and flavonol composition was correlated with biologically effective degree days, exhibiting a relationship with grape maturity...
June 5, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28573229/analysis-of-phenolic-and-flavonoids-of-wild-ephedra-alata-plant-extracts-by-lc-pda-and-lc-ms-and-their-antioxidant-activity
#8
Fuad Al-Rimawi, Saleh Abu-Lafi, Jehad Abbadi, Ayman A A Alamarneh, Raneen A Sawahreh, Imad Odeh
BACKGROUND: Ephedra is among Palestinian medicinal plants that are traditionally used in folkloric medicine for treating many diseases. Ephedra is known to have antibacterial and antioxidant effects. The goal of this study is to evaluate the antioxidant activity of different extracts from the Ephedra alata plant growing wild in Palestine, and to analyze their phenolic and flavonoid constituents by HPLC/PDA and HPLC/MS. MATERIALS AND METHODS: Samples of the Ephedra alata plant grown wild in Palestine were extracted with three different solvents namely, 100% water, 80% ethanol, and 100% ethanol...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28558340/dynamic-changes-of-flavonoids-in-abelmoschus-manihot-different-organs-at-different-growth-periods-by-uplc-ms-ms
#9
Xinxin Pan, Leyue Du, Jinhua Tao, Shu Jiang, Dawei Qian, Jinao Duan
Abelmoschus manihot (Linn.) Medicus has been clinically used to treat chronic kidney disease, oral ulcers, burns, and dysmenorrhea in China for many centuries. The major pharmacologically-active components of A. manihot are flavonoids. In this study, a rapid and highly sensitive UPLC-MS/MS analysis method was established and successfully applied to the simultaneous determination of five major flavonoids (rutin, hyperoside, isoquercitrin, quercetin, and myricetin) in different parts of A. manihot harvested at ten growth periods...
August 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28550653/phytochemical-profile-and-angiotensin-i-converting-enzyme-ace-inhibitory-activity-of-limonium-michelsonii-lincz
#10
Janar Jenis, Jeong Yoon Kim, Zia Uddin, Yeong Hun Song, Hyeong-Hwan Lee, Ki Hun Park
Members of the genus Limonium are widely used as medicinal herbs due to their health-promoting effects, such as an ability to improve blood circulation by inhibiting angiotensin I converting enzyme (ACE). While the potential of L. michelsonii Lincz. (a medicinal plant endemic to Kazakhstan) to inhibit ACE has been demonstrated, the inhibitory activities of its secondary metabolites have not been explored. In this work, the principal phenolic compounds (1-20) among these metabolites were isolated to determine the components responsible for ACE inhibition...
May 26, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28539711/flavonoids-isolated-from-the-flowers-of-limonium-bicolor-and-their-in-vitro-antitumor-evaluation
#11
Jian Chen, Jiehui Teng, Li Ma, Haiying Tong, Bingru Ren, Linshan Wang, Weilin Li
BACKGROUND: Limonium bicolor, a halophytic species, can grow in saline or saline-alkali soil, is well known as a traditional Chinese medicine. Recently it attracted much attention for its treatment for cancer. OBJECTIVE: The present study was performed to evaluate this species from the phytochemical standpoint and the possible relationship between the antitumor activity and its natural products. MATERIALS AND METHODS: The chemical constituents from the flowers of L...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28528091/antiproliferative-activity-of-ontario-grown-onions-against-colorectal-adenocarcinoma-cells
#12
Abdulmonem I Murayyan, Cynthya M Manohar, Gordon Hayward, Suresh Neethirajan
Cancer is the leading cause of mortality in Canada and other industrialized nations; the development of new/improved cancer therapies is desperately needed and continues to be a major focus of cancer research. Flavonoids, which are found in high levels in onions, have been shown to exert antiproliferative and potentially anti-cancer activities. To test their therapeutic potential, we assessed the antiproliferative, cytotoxic, apoptosis-inducing, and anti-migratory activities of five onion varieties grown in Ontario against human adenocarcinoma (Caco-2) cells...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28508699/antimicrobial-anticancer-and-antioxidant-compounds-from-premna-resinosa-growing-in-saudi-arabia
#13
Dina A Albadawi, Ramzi A Mothana, Jamal M Khaled, Abdelkhader E Ashour, Ashok Kumar, Sheikh F Ahmad, Mansour S Al-Said, Adnan J Al-Rehaily, Nawal M Almusayeib
CONTEXT: Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage. OBJECTIVE: This study evaluates the anticancer, antimicrobial and antioxidant activities of P. resinosa, and isolates some responsible constituents. MATERIALS AND METHODS: The methanol extract of P. resinosa aerial parts and its fractions (n-hexane, dichloromethane, ethyl acetate and n-butanol) were tested...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28492713/flavonoids-and-anti-oxidant-activity-mediated-gastroprotective-action-of-leathery-murdah-terminalia-coriacea-roxb-wight-arn-leaf-methanolic-extract-in-rats
#14
Mohammed Safwan Ali Khan, Shaaz Nazan, Abdul Manan Mat Jais
BACKGROUND: Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. from family Combretaceae is used in Ayurveda and Siddha traditional systems of medicine to heal ulcers. OBJECTIVE: The present study was conducted to assess the gastroprotective effect and understand the fundamental mechanism of action of Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. Leaf Methanolic Extract. METHODS: The test extract was screened for anti-ulcer activity by Aspirin induced ulcerogenesis in pyloric ligation and ethanol induced gastric ulcers at three doses - 125, 250, and 500 mg/kg, p...
May 8, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28487704/a-combined-comparative-transcriptomic-metabolomic-and-anatomical-analyses-of-two-key-domestication-traits-pod-dehiscence-and-seed-dormancy-in-pea-pisum-sp
#15
Iveta Hradilová, Oldřich Trněný, Markéta Válková, Monika Cechová, Anna Janská, Lenka Prokešová, Khan Aamir, Nicolas Krezdorn, Björn Rotter, Peter Winter, Rajeev K Varshney, Aleš Soukup, Petr Bednář, Pavel Hanáček, Petr Smýkal
The origin of the agriculture was one of the turning points in human history, and a central part of this was the evolution of new plant forms, domesticated crops. Seed dispersal and germination are two key traits which have been selected to facilitate cultivation and harvesting of crops. The objective of this study was to analyze anatomical structure of seed coat and pod, identify metabolic compounds associated with water-impermeable seed coat and differentially expressed genes involved in pea seed dormancy and pod dehiscence...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28475126/phenolic-compositions-and-antioxidant-properties-in-bark-flower-inner-skin-kernel-and-leaf-extracts-of-castanea-crenata-sieb-et-zucc
#16
Phung Thi Tuyen, Tran Dang Xuan, Do Tan Khang, Ateeque Ahmad, Nguyen Van Quan, Truong Thi Tu Anh, La Hoang Anh, Truong Ngoc Minh
In this study, different plant parts (barks, flowers, inner skins, kernels and leaves) of Castanea crenata (Japanese chestnut) were analyzed for total phenolic, flavonoid, and tannin contents. Antioxidant properties were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), reducing power, and β-carotene bleaching methods. The highest total phenolic and tannin contents were found in the inner skins (1034 ± 7.21 mg gallic acid equivalent/g extract and 253...
May 5, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28463801/anti-cancer-activity-of-myricetin-against-human-papillary-thyroid-cancer-cells-involves-mitochondrial-dysfunction-mediated-apoptosis
#17
Tae Kwun Ha, Inae Jung, Mi Eun Kim, Sung Kwon Bae, Jun Sik Lee
Thyroid cancer is the most common endocrine malignancy and can range in severity from relatively slow-growing occult differentiated thyroid cancer to uniformly aggressive and fatal anaplastic thyroid cancer. A subset of patients with papillary thyroid cancer present with aggressive disease that is refractory to conventional treatment. Myricetin is a flavonol compound found in a variety of berries as well as walnuts and herbs. Previous studies have demonstrated that myricetin exhibits anti-cancer activity against several tumor types...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28456117/correlation-of-binding-efficacies-of-dna-to-flavonoids-and-their-induced-cellular-damage
#18
Asmita Das, Debashis Majumder, Chabita Saha
Flavonoids are dietary intakes which are bestowed with several health benefits. The most studied property of flavonoids is their antioxidant efficacy. Among the chosen flavonoids Quercetin, Kaempferol and Myricetin is catagorized as flavonols whereas Apigenin and Luteolin belong to the flavone group. In the present study anti-cancer properties of flavonoids are investigated on the basis of their binding efficacy to ct-DNA and their ability to induce cytotoxicity in K562 leukaemic cells. The binding affinities of the flavonoids with calf thymus DNA (ct-DNA) are in the order Quercetin>Myricetin>Luteolin>Kaempferol>Apigenin...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28447255/phenolic-compounds-volatiles-and-antioxidant-capacity-of-white-myrtle-berry-liqueurs
#19
Gabriele Serreli, Igor Jerković, Katarzyna Angelika Gil, Zvonimir Marijanović, Viviana Pacini, Carlo Ignazio Giovanni Tuberoso
The aim of this research was to evaluate the antioxidant capacity and physical-chemical characteristics of commercial white myrtle berry (Myrtus communis L. var. leucocarpa DC) liqueur (WMBL). The total phenolic (TP) content was measured spectrophotometrically, applying a modified Folin-Ciocalteu's method, and phenolic compounds were identified by high-performance liquid chromatography (HPLC) coupled with electrospray mass spectrometry, and quantified by HPLC coupled with ultraviolet/visible detection. The antioxidant capacities were evaluated by FRAP, CUPRAC, DPPH(•), and ABTS(•+) assays...
June 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28439667/myricetin-induced-brown-adipose-tissue-activation-prevents-obesity-and-insulin-resistance-in-db-db-mice
#20
Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
PURPOSE: Myricetin, a dietary flavonoid, is effective in the treatment of obesity and insulin resistance by increasing glucose transport and lipogenesis in adipocyte and diminishing systemic inflammation in obesity. However, it has not been revealed yet whether myricetin is associated with brown adipose tissue (BAT) activation that tightly mediates systemic energy metabolism. Therefore, this study assessed whether myricetin activated brown adipose tissue in db/db mouse. METHODS: Myricetin (400 mg/kg) in distilled water was fed daily by oral gavage to leptin receptor-deficient db/db male mice at 4 weeks of age for 14 weeks...
April 24, 2017: European Journal of Nutrition
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