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https://www.readbyqxmd.com/read/27916965/pathway-analysis-and-metabolites-identification-by-metabolomics-of-etiolation-substrate-from-fresh-cut-chinese-water-chestnut-eleocharis-tuberosa
#1
Yi-Xiao Li, Yong-Gui Pan, Feng-Ping He, Meng-Qi Yuan, Shang-Bin Li
Fresh-cut Chinese water chestnuts (CWC) turn yellow after being peeled, reducing their shelf life and commercial value. Metabolomics, the systematic study of the full complement of small molecular metabolites, was useful for clarifying the mechanism of fresh-cut CWC etiolation and developing methods to inhibit yellowing. In this study, metabolic alterations associated with etiolation at different growth stages (0 day, 2 days, 3 days, 4 days, 5 days) from fresh-cut CWC were investigated using LC-MS and analyzed by pattern recognition methods (principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal projection to latent structures-discriminant analysis (OPLS-DA))...
December 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27896020/identification-of-phenolic-secondary-metabolites-from-schotia-brachypetala-sond-fabaceae-and-demonstration-of-their-antioxidant-activities-in-caenorhabditis-elegans
#2
Mansour Sobeh, Esraa ElHawary, Herbenya Peixoto, Rola M Labib, Heba Handoussa, Noha Swilam, Ahmed H El-Khatib, Farukh Sharapov, Tamer Mohamed, Sonja Krstin, Michael W Linscheid, Abdel Nasser Singab, Michael Wink, Nahla Ayoub
BACKGROUND: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alcohol extract from S. brachypetala leaves (SBE) using LC/HRESI/MS/MS and NMR and prove their antioxidant capabilities using novel methods. METHODS: In vitro assays; DPPH, TEAC persulfate decolorizing kinetic and FRAP assays, and in vivo assays: Caenorhabditis elegans strains maintenance, Intracellular ROS in C...
2016: PeerJ
https://www.readbyqxmd.com/read/27885509/inhibitory-effect-of-flavonoids-against-ns2b-ns3-protease-of-zika-virus-and-their-structure-activity-relationship
#3
Hee-Jung Lim, Thi Thanh Hanh Nguyen, Nahyun M Kim, Jun-Seong Park, Tae-Su Jang, Doman Kim
OBJECTIVES: To determine the inhibitory activities of flavonoids against NS2B-NS3 protease of ZIKA virus (ZIKV NS2B-NS3(pro)) expressed in Escherichia coli BL21 (DE3) and their structure activity relationship. RESULTS: ZIKV NS2B-NS3(pro) was expressed in E. coli BL21(DE3) as a 35 kDa protein. It had a K m of 26 µM with the fluorogenic peptide Dabcyl-KTSAVLQSGFRKME-Edan. The purified ZIKV NS2B-NS3(pro) was used for inhibition and kinetic assays to determine the activities of 22 polyphenol compounds...
November 24, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27877156/a-chitosan-coating-containing-essential-oil-from-origanum-vulgare-l-to-control-postharvest-mold-infections-and-keep-the-quality-of-cherry-tomato-fruit
#4
Tainá A Barreto, Sonalle C A Andrade, Janeeyre F Maciel, Narciza M O Arcanjo, Marta S Madruga, Bruno Meireles, Ângela M T Cordeiro, Evandro L Souza, Marciane Magnani
The efficacy of an edible chitosan coating (CHI; 4 mg/mL) and Origanum vulgare L. essential oil (OVEO; 1.25 μL/mL) for maintaining the quality of cherry tomato fruit during storage at room (25°C; 12 days) and cold (12°C; 24 days) temperatures was assessed. CHI and OVEO in combination showed in vitro fungicidal effects against R. stolonifer and Aspergillus niger. CHI-OVEO coating reduced the incidence of black mold and soft rot caused by these fungi in artificially contaminated cherry tomato fruit during storage at both temperatures...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27866749/inter-population-and-inter-organ-distribution-of-the-main-polyphenolic-compounds-of-epilobium-angustifolium
#5
Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen
Rosebay willowherb (Epilobium angustifolium) contains large amounts of polyphenolic compounds, including tellimagrandin I-based oligomeric ellagitannins (ETs). The aim of this study was to assess the interpopulational and inter-organ variability of the polyphenol fingerprint of E. angustifolium. Seven ETs, 11 flavonol glycosides and neochlorogenic acid were quantified by UHPLC-DAD-ESI-QqQ-MS in the leaves, flowers and stem parts of plants from 10 populations. Total polyphenol content of leaves and flowers ranged from 150 to 200 mg/g dry wt, of which 90% was constituted by dimeric to heptameric ETs...
November 17, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27856006/insights-into-the-aggregation-mechanism-of-a%C3%AE-25-40
#6
Jian Xiong, Renee D JiJi
The hydrophobic fragment of the Alzheimer's related β-amyloid (Aβ) peptide, Aβ(25-40), aggregates and forms insoluble amyloid fibrils at a rate similar to the full-length peptide. In order to gain insight into the fibrillization of Aβ(25-40) and the ability of the flavonoid myricetin to inhibit its aggregation, the isoleucine at position 32 (I32A) and the glycine at position 37 (G37A) in the full-length peptide were replaced with alanine. Thioflavin T assays indicate that substitution of isoleucine for alanine significantly reduces the rate and extent of fibrillization compared to the Aβ(25-40) and G37A peptides...
January 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/27820960/isolation-of-a-new-compound-2-butanone-4-glucopyranoside-6-o-gallate-and-other-8-compounds-from-the-anti-inflammatory-leave-extracts-of-memecylon-edule-roxb
#7
Somsak Nualkaew, Suchitra Thongpraditchote, Yuwadee Wongkrajang, Kaoru Umehara, Hiroshi Noguchi
This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6'-O-gallate (1) with eight known compounds, namely, 3,3'-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)-dihydromyricetin-4'-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9)...
November 7, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27818668/an-approach-based-on-hplc-fingerprint-and-chemometrics-to-quality-consistency-evaluation-of-matricaria-chamomilla-l-commercial-samples
#8
Agnieszka Viapiana, Wiktoria Struck-Lewicka, Pawel Konieczynski, Marek Wesolowski, Roman Kaliszan
Chamomile has been used as an herbal medication since ancient times and is still popular because it contains various bioactive phytochemicals that could provide therapeutic effects. In this study, a simple and reliable HPLC method was developed to evaluate the quality consistency of nineteen chamomile samples through establishing a chromatographic fingerprint, quantification of phenolic compounds and determination of antioxidant activity. For fingerprint analysis, 12 peaks were selected as the common peaks to evaluate the similarities of commercial samples of chamomile obtained from different manufacturers...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27794509/effects-of-crude-hydroalcoholic-extract-of-syzygium-cumini-l-skeels-leaves-and-continuous-aerobic-training-in-rats-with-diabetes-induced-by-a-high-fat-diet-and-low-doses-of-streptozotocin
#9
G Baldissera, N D M Sperotto, H T Rosa, J G Henn, V F Peres, D J Moura, R Roehrs, E L G Denardin, P Dal Lago, R B Nunes, J Saffi
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Syzygium cumini (L.) or Skeels (Myrtaceae) are widely used in Brazilian folk medicine to treat diabetes. AIM OF THE STUDY: The present study evaluated the functional capacity, biochemical parameters, oxidative stress and DNA damage from eight weeks of intervention with a crude hydroalcoholic extract of S. cumini leaves (EBH) and continuous aerobic training (TAC) in diabetic (D) rats. MATERIALS AND METHODS: A hydroalcoholic (50%) extract was prepared by ultrasound and phytochemical parameters (total phenols, total tannins and myricetin content) were analyzed...
October 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27788158/genetics-and-biochemistry-of-zero-tannin-lentils
#10
Mahla Mirali, Randy W Purves, Rob Stonehouse, Rui Song, Kirstin Bett, Albert Vandenberg
The zero-tannin trait in lentil is controlled by a single recessive gene (tan) that results in a phenotype characterized by green stems, white flowers, and thin, transparent, or translucent seed coats. Genes that result in zero-tannin characteristics are useful for studies of seed coat pigmentation and biochemical characters because they have altered pigmentation. In this study, one of the major groups of plant pigments, phenolic compounds, was compared among zero-tannin and normal phenotypes and genotypes of lentil...
2016: PloS One
https://www.readbyqxmd.com/read/27787697/evaluation-of-total-flavonoids-myricetin-and-quercetin-from-hovenia-dulcis-thunb-as-inhibitors-of-%C3%AE-amylase-and-%C3%AE-glucosidase
#11
Yonghong Meng, Anping Su, Shuang Yuan, Huaguo Zhao, Siyuan Tan, Chingyuan Hu, Hong Deng, Yurong Guo
This study was designed to investigate the inhibition effect and mechanism of total flavonoids, myricetin and quercetin extracted from Hovenia dulcis Thunb. on α-amylase and α-glucosidase in order to explore the potential use of Hovenia flavonoids in alleviating postprandial hyperglycemia. The results demonstrate that total flavonoids, myricetin, and quercetin were effective inhibitors of α-amylase with IC50 values of 32.8, 662 and 770 μg ml(-1), respectively. And all three were effective inhibitors of α-glucosidase with IC50 values of 8, 3 and 32 μg ml(-1), respectively...
October 27, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27780135/structural-characterization-of-a-novel-derivative-of-myricetin-from-mimosa-pudica-as-an-anti-proliferative-agent-for-the-treatment-of-cancer
#12
Joby Jose, A T Dhanya, Karickal R Haridas, T M Sumesh Kumar, Sony Jayaraman, E Jayadevi Variyar, Sudheesh Sudhakaran
The study was initiated to determine the anticancer activity of a novel compound isolated from the plant Mimosa pudica. The structure of the compound was identified as a derivative of myricetin having alkyl, hydroxy alkyl and methyl substitutions on the basis of spectral evidences (UV-vis, FT-IR, (1)H NMR and Mass spectra). The isolated compound was interpreted as 2-(2',6'-dimethyl-3',4',5'-alkyl or hydroxy alkyl substituted phenyl)-3-oxy-(alkyl or hydoxy alkyl)- 5,7-dihydroxy-chromen-4-one. In vitro evaluation of anticancer activity against human lung adenocarcinoma cell line (A549) and human erythroleukemic cell line (K562) were conducted using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27769938/a-bioactivity-guided-study-on-the-antibacterial-activity-of-hertia-cheirifolia-l-extracts
#13
Kaouther Majouli, Assia Hamdi, Kamel Msaada, Abderraouf Kenani
This study was carried out with the objective to investigate the antibacterial activity of Hertia cheirifolia L. extracts against Gram-positive and Gram-negative strains including Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Bacillus licheniformis, Esherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Salmonella enterica (CIP 8039) and Salmonella typhimirium. The results of this antibacterial screening showed that the ethyl acetate (EtOAc) extracts had the best activity against the tested microorganisms...
October 18, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27765936/myricetin-a-potent-natural-agent-for-treatment-of-diabetic-skin-damage-by-modulating-timp-mmps-balance-and-oxidative-stress
#14
Zijian Wu, Xuemin Zheng, Min Gong, Ying Li
Foot ulceration is a major cause of morbidity in patients with diabetes, and abnormal peripheral neuropathy often results in hospitalization. Up-regulation of matrix metalloproteinases and down-regulation of tissue inhibitor of metalloproteinase 1 are noted to be distinctive biological functions of diabetic dermal fibroblasts. The aim of this study was to evaluate the biological effects of modified retinoids on diabetic fibroblasts. Myricetin, a natural compound, balances the TIMP1/MMP ratio and oxidative stress in diabetic fibroblasts...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27757032/pluronic-based-micelle-encapsulation-potentiates-myricetin-induced-cytotoxicity-in-human-glioblastoma-cells
#15
Xiang-Jun Tang, Kuan-Ming Huang, Hui Gui, Jun-Jie Wang, Jun-Ti Lu, Long-Jun Dai, Li Zhang, Gang Wang
As one of the natural herbal flavonoids, myricetin has attracted much research interest, mainly owing to its remarkable anticancer properties and negligible side effects. It holds great potential to be developed as an ideal anticancer drug through improving its bioavailability. This study was performed to investigate the effects of Pluronic-based micelle encapsulation on myricetin-induced cytotoxicity and the mechanisms underlying its anticancer properties in human glioblastoma cells. Cell viability was assessed using a methylthiazol tetrazolium assay and a real-time cell analyzer...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27755647/effect-of-oak-chips-on-evolution-of-phenolic-compounds-and-color-attributes-of-bog-bilberry-syrup-wine-during-bottle-aging
#16
Shuxun Liu, Shaoyang Wang, Guanshen Yuan, Xiaoyu Ouyang, Yaran Liu, Baoqing Zhu, Bolin Zhang
This study investigated the evolution of phenolic compounds of bog bilberry syrup wine during a bottle-aging process, and further estimated the oak chip treatment on the wine color alteration. The wine was macerated with oak chips (2 or 5 g/L under light or medium toasting level) for 20 d and then bottle-aged for 6 mo. Results showed that the oak chip treatment significantly increased the content of phenolic compounds and enhanced the copigmented anthocyanin level before aging. It also resulted in an increase on a(*) and C(*) but a decrease on L(*) , b(*) , and H(*) of the wine...
October 18, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27713953/myricetin-alleviates-cuprizone-induced-behavioral-dysfunction-and-demyelination-in-mice-by-nrf2-pathway
#17
Qianying Zhang, Zhike Li, Shuangchan Wu, Xiaofei Li, Ying Sang, Jian Li, Yunhui Niu, Hong Ding
Multiple sclerosis (MS) is a demyelinating disease occurring in the central nervous system. In the present study, we evaluated the function of myricetin on the alleviation of behavioral dysfunction and myelin protection in the cuprizone-induced demyelination model. Mice were daily fed with fodder including 0.2% cuprizone and were administrated myricetin (100 mg kg(-1)) by gavage administration for 5 weeks. The treatment of myricetin ameliorated hyper-locomotion and behavior impairment induced by cuprizone toxicity...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27711848/metabolism-and-growth-inhibitory-activity-of-cranberry-derived-flavonoids-in-bladder-cancer-cells
#18
Jeevan K Prasain, Rajani Rajbhandari, Adam B Keeton, Gary A Piazza, Stephen Barnes
In the present study, anti-proliferative activities of cranberry derived flavonoids and some of their in vivo metabolites were evaluated using a panel of human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC). Among the compounds tested, quercetin 3-O-glucoside, isorhamnetin (3'-O-methylquercetin), myricetin and quercetin showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27690414/urinary-clearance-of-cranberry-flavonol-glycosides-in-humans
#19
Yifei Wang, Ajay P Singh, Heather N Nelson, Amanda J Kaiser, Nicolette C Reker, Tisha L Hooks, Ted Wilson, Nicholi Vorsa
Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225 and 360 minutes post-ingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified...
October 3, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#20
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
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