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https://www.readbyqxmd.com/read/29025433/the-role-of-the-glycosyl-moiety-of-myricetin-derivatives-in-anti-hiv-1-activity-in-vitro
#1
Joseph T Ortega, Alirica I Suárez, Maria L Serrano, Jani Baptista, Flor H Pujol, Hector R Rangel
BACKGROUND: Plant extracts are sources of valuable compounds with biological activity, especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants that has been described as an inhibitor of Human immunodeficiency virus type 1 (HIV-1) through its action against the HIV reverse transcriptase, but myricetin derivatives have not been fully studied. The aim of this study was to evaluate the anti-HIV-1 activity of glycosylated metabolites obtained from Marcetia taxifolia and derived from myricetin: myricetin rhamnoside and myricetin 3-(6-rhamnosylgalactoside)...
October 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28982053/phosphate-stresses-affect-ionome-and-metabolome-in-tea-plants
#2
Zhaotang Ding, Sisi Jia, Yu Wang, Jun Xiao, Yinfei Zhang
In order to study the response of tea plants to P stress, we conducted the ionomic and metabolomic analysis by ICP-OES, GC-MS and LC-MS. The results demonstrated that P was antagonistic with S, and was cooperative with Cu, Zn, Mn and Fe under P-deficiency. However, P was antagonistic with Mn, Fe and S, and was cooperative with Cu and Zn under P-excess. Moreover, P-deficiency or excess reduced the syntheses of flavonoids and phosphorylated metabolites. P-deficiency decreased the amount of glutamate and increased the content of glutamine, while P-excess decreased the content of glutamine...
September 14, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28968930/protective-potential-of-parrotiopsis-jacquemontiana-decne-rehder-on-carbon-tetrachloride-induced-hepatotoxicity-in-experimental-rats
#3
Saima Ali, Muhammad Rashid Khan, Moniba Sajid
The current study aimed at exploring hepatoprotective potential of Parrotiopsis jacquemontiana leaves methanol extract (PJM) in rat. PJM constituted of significant amount of total phenolic and total flavonoid content. PJM and ethyl acetate fraction (PJE) exhibited strong antioxidant potential (DPPH, hydroxyl ion, nitric oxide, iron chelating, β-carotene, reducing power and phosphomolybdate assay) in comparison to other extracts. CCl4 toxicity displayed significant (p<0.05) increase in level of TBARS, H2O2, nitrite while a decrease in SOD, CAT, POD and GSH in liver samples of CCl4 treated group...
September 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28952614/quercetin-and-its-analogues-optical-and-acido-basic-properties
#4
Michal Biler, David Biedermann, Kateřina Valentová, Vladimír Křen, Martin Kubala
This study is focused on eight structurally analogous natural flavonoids that exhibit a wide range of biological activities, which are of interest in pharmacy, cosmetics and the food industry. Using both experimental and theoretical approaches, we relate their fundamental physico-chemical properties to the structural motifs, with particular focus on UV/Vis absorption properties and pH dependence. We highlight the role of the C2-C3 double bond, whose presence or absence is responsible for the switch between absorption bands in the UVB and UVA regions, which is rationalized by strong modification of the involved molecular orbitals...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28940200/unravelling-the-inhibitory-effect-of-dihydromyricetin-on-heterocyclic-aromatic-amines-formation
#5
Bin Zhou, Yueliang Zhao, Xichang Wang, Kawing Cheng, Mingfu Wang
BACKGROUND: Heterocyclic aromatic amines (HAAs) are mutagens and rodent carcinogens. Flavonoids have attracted considerable attention for development into effective inhibitors against the formation of genotoxic heterocyclic aromatic amines (HAAs) in thermally processed foods. RESULTS: The inhibitory effect of dihydromyricetin (DMY) on the formation of key HAAs, including 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) was significant...
September 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28935551/anti-trypanosoma-anti-leishmania-and-cytotoxic-activities-of-natural-products-from-psidium-brownianum-mart-ex-dc-and-psidium-guajava-var-pomifera-analysed-by-lc-ms
#6
Celestina Elba Sobral de Souza, Ana Raquel Pereira da Silva, Maria Celeste Vega Gomez, Míriam Rolóm, Cathia Coronel, José Galberto Martins da Costa, Amanda K Sousa, Larissa A Rolim, Francisco Hugo Sobral de Souza, Henrique Douglas Melo Coutinho
Neglected diseases are those that are prevalent in developing countries, even with a rich biodiversity. These diseases still persist because of the lack of scientific studies, government negligence or failures of the public health system. This study aims to identify the composition of extracts and fractions from Psidium brownianum and Psidium guajava through LC-MS, to evaluate its in vitro anti-parasitic and cytotoxic activity against Trypanosoma cruzi, Leishmania brasiliensis and L. infantum epismastigote and promastigote forms, as well as mammalian cells...
December 2017: Acta Tropica
https://www.readbyqxmd.com/read/28929656/-analysis-and-utilization-value-discussion-of-multiple-chemical-composition-in-different-tissues-of-abelmoschus-manihot
#7
Jie Liu, Sheng Guo, Jin-Ao Duan, Hui Yan, Da-Wei Qian, Hai-Tao Tang, Ren-Mao Tang
This research is to analyze the resourceful chemical composition in different tissues (root, stem, leaf and flower) of Abelmoschus manihot and evaluate their utilizing value. The flavonoids, soluble polysaccharides, cellulose, nucleosides and amino acids in the different tissues of A. manihot were determined by HPLC coupled with UV-Vis spectrophotpmetry, and UPLC-TQ/MS. The flowers are rich in the resourceful chemical compositions of flavonoids which mainly consist of hyperoside, isoquercitrin, cotton-8-O-glucuronide, myricetin, quercetin-3'-O-glucoside, rutin and quercetin...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928532/effect-of-interaction-of-epigallocatechin-gallate-and-flavonols-on-color-alteration-of-simulative-green-tea-infusion-after-thermal-treatment
#8
Qianying Dai, Yuanyuan He, Chit-Tang Ho, Jing Wang, Shujuan Wang, Yue Yang, Liping Gao, Tao Xia
Epigallocatechin gallate (EGCG) and flavonols are important phenolic compounds in green tea. These compounds are sensitive to thermal condition and their structural alteration results in making browning the green tea infusion. This study aimed to research the interaction between EGCG and flavonols during thermal infusion. EGCG and flavonols model solutions were prepared based on concentration in green tea infusion, and their colors appearance and attributes were analyzed in 10 h by thermal treatment. Results showed that kaempferol, quercetin, and myricetin accelerated the oxidation of EGCG and made the model solution browning...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28924148/investigation-of-the-inhibition-effect-and-mechanism-of-myricetin-to-suilysin-by-molecular-modeling
#9
Xiaodi Niu, Lin Sun, Guizhen Wang, Yawen Gao, Yanan Yang, Xiyan Wang, Hongsu Wang
In the present study, the inhibitory effect and mechanism of myricetin, a natural flavonoid compound, in relation to Suilysin (SLY) were investigated through molecular dynamics simulations, mutational analysis and fluorescence-quenching assays. Myricetin is a potential inhibitor that does not exhibit antimicrobial activity but has been shown to inhibit SLY cytotoxicity. Molecular dynamics simulations and mutational analysis revealed that myricetin binds directly to SLY in the gap between domains 2 and 3, an important region for oligomerization and pore formation...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28917148/self-nanoemulsifying-drug-delivery-systems-of-myricetin-formulation-development-characterization-and-in-vitro-and-in-vivo-evaluation
#10
Jin Qian, Houjun Meng, Lei Xin, Mengxin Xia, Hongyi Shen, Guowen Li, Yan Xie
Despite various pharmacological effects, myricetin (Myr) shows low oral bioavailability (<10%) due to its poor solubility, which limits its applications. To address this problem, self-nanoemulsifying drug delivery systems (SNEDDS) were developed by investigating the solubility of Myr in various excipients, constructing pseudo-ternary phase diagrams, and optimizing based on droplet size and emulsification efficacy after drug loading. The obtained Myr-SNEDDS were F04 (Capryol 90/Cremophor RH 40/PEG 400 4:3:3), F08 (Capryol 90/CremophorRH40/1,2-propanediol 4:3:3), F13 (Capryol 90/Cremophor EL/Transcutol HP 4:3:3) and F15 (Capryol 90/Cremephor RH 40/Transcutol HP 2:7:1), with droplet sizes less than 200nm...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28895264/phenolic-compound-diversity-explored-in-the-context-of-photo-oxidative-stress-protection
#11
Kristóf Csepregi, Éva Hideg
INTRODUCTION: Phenolic compounds are a chemically diverse group of plant secondary metabolites with important roles both in plant stress defence and human nutrition. OBJECTIVE: To explore structure-function relations potentiating phenolic compounds to promote leaf acclimation to light stress by excess photosynthetically active radiation (photoinhibition) and by solar ultraviolet (UV) radiation. METHODOLOGY: We report singlet oxygen and hydrogen peroxide antioxidant capacities and UV-absorbing properties of 27 flavonoids and 11 phenolic acids...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28885580/wound-healing-potential-of-chlorogenic-acid-and-myricetin-3-o-%C3%AE-rhamnoside-isolated-from-parrotia-persica
#12
Sara E Moghadam, Samad N Ebrahimi, Peyman Salehi, Mahdi Moridi Farimani, Matthias Hamburger, Ehsan Jabbarzadeh
Wound healing is a complex physiological process that is controlled by a well-orchestrated cascade of interdependent biochemical and cellular events, which has spurred the development of therapeutics that simultaneously target these active cellular constituents. We assessed the potential of Parrotia persica (Hamamelidaceae) in wound repair by analyzing the regenerative effects of its two main phenolic compounds, myricetin-3-O-β-rhamnoside and chlorogenic acid. To accomplish this, we performed phytochemical profiling and characterized the chemical structure of pure compounds isolated from P...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28872626/anti-melanogenic-effects-of-flavonoid-glycosides-from-limonium-tetragonum-thunb-bullock-via-inhibition-of-tyrosinase-and-tyrosinase-related-proteins
#13
Seul-Gi Lee, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong
Overproduction and stimulation of tyrosinase result in increased melanogenesis of which several skin disorders such as freckles, spots, and hyperpigmentation appear as complications. Limonium tetragonum is a halophyte well-known for its antioxidative properties. This study investigated the anti-melanogenic effects of solvent-partitioned L. tetragonum extracts (LTEs) and its bioactive constituents, two isolated flavonoid glycosides. Current study followed a set of experiments on B16-F10 mouse melanoma cell model with a focus on tyrosinase activity and production...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28845147/polyphenols-of-carm%C3%A3-n%C3%A3-re-grapes
#14
Nils Leander Huamán-Castilla, María Salomé Mariotti-Celis, José Ricardo Pérez-Correa
Carménère is the emblematic grape of Chile. Recent studies indicate that it has a different polyphenolic profile than other commercial varieties of grape among other factors, due to its long maturation period. The grape and wine of Carménère stand out for having high concentrations of anthocyanins (malvidin), flavonols (quercetin and myricetin) and flavanols (catechin, epicatechin and epigallocatechin). These compounds are related to the distinctive characteristic of Carménère wine regarding astringency and color...
June 2017: Mini-reviews in Organic Chemistry
https://www.readbyqxmd.com/read/28836477/antithrombocytopenic-and-immunomodulatory-potential-of-metabolically-characterized-aqueous-extract-of-carica-papaya-leaves
#15
Varisha Anjum, Poonam Arora, Shahid Husain Ansari, Abul Kalam Najmi, Sayeed Ahmad
CONTEXT: Carica papaya Linn. (Caricaceae) leaf (CPL) juice has long been traditionally used in ethnomedicine for dengue fever. OBJECTIVE: The study examines the effects of standardized CPL aqueous extract (SCPLE) on platelet count, extramedullary haematopoiesis (EMH), and immunomodulation in cyclophosphamide (CP)-induced animal model of thrombocytopenia. MATERIALS AND METHODS: The extract was analyzed for myricetin, caffeic acid, trans-ferulic acid, and kaempferol using HPTLC for standardization followed by UPLC-qTOF/MS fingerprinting for metabolite signature...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28834706/flavonoids-induced-redox-cycling-of-copper-ions-leads-to-generation-of-reactive-oxygen-species-a-potential-role-in-cancer-chemoprevention
#16
Hussain Arif, Aamir Sohail, Mohd Farhan, Ahmed Abdur Rehman, Aamir Ahmad, S M Hadi
Flavonoids, a class of polyphenols are known to be effective inducers of apoptosis and cytotoxicity in cancer cells. It is believed that antioxidant activity of polyphenols cannot fully account for induction of apoptosis and chemotherapeutic prevention in various cancers. In this article, by employing single cell alkaline gel electrophoresis (comet assay), we established that antioxidants, flavonoids such as (myricetin=MN, fisetin=FN, quercetin=QN, kaempferol=KL and galangin=GN) can cause cellular DNA breakage, also act as pro-oxidant in presence of transition metal ion such as copper...
August 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28834104/myricetin-protects-keratinocyte-damage-induced-by-uv-through-i%C3%AE%C2%BAb-nf%C3%AE%C2%BAb-signaling-pathway
#17
Jing Xie, Yanyan Zheng
OBJECTIVE: The aim of this study was to evaluate the potential molecular mechanism of myricetin that protecting cells from photodamage. METHODS: Myricetin had broadly chemopreventive effects and anti-inflammatory properties. The effect of myricetin was assessed on HaCaT cells. Cell viability assay was carried out. Reactive oxygen species (ROS) level was measured. The expression of pro-inflammatory factor COX2 was determined by real-time PCR and Western blot. The protein levels of p-IκBa and IκBa were determined by Western blot...
August 17, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28818532/myricetin-solid-lipid-nanoparticles-stability-assurance-from-system-preparation-to-site-of-action
#18
Dina M Gaber, Noha Nafee, Osama Y Abdallah
Myricetin - a natural flavonoid - has attracted a great interest due to its antioxidant and free-radical scavenging potential. However, its physicochemical instability critically impairs its dosage form design, evaluation and administration. In an attempt to protect from degradation, MYR was encapsulated into Gelucire-based solid lipid nanoparticles (SLNs). The impact of medium pH, processing temperature and different additives on the drug degradation either in free or nanoencapsulated form was assessed. MYR stability was further monitored in essential biorelevant fluids...
August 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28808377/anti-inflammatory-potential-of-petiveria-alliacea-on-activated-raw264-7-murine-macrophages
#19
Rosa Martha Perez Gutierrez, Carlos Hoyo-Vadillo
BACKGROUND: Defense and protection to multiple harmful stimuli are the inflammation, when is self-amplified and uncontrolled is the basis of the pathogenesis of a wide variety of inflammatory illness. The aim of this study was to evaluate if Petiveria alliacea could attenuate inflammation in a murine model of RAW264 macrophages the involved model and its involved mechanism. MATERIALS AND METHODS: The ethanol extract from P. alliacea was precipitated with water and supernatant was used for this study (PW)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28802134/investigating-the-features-in-differential-absorbance-spectra-of-nom-associated-with-metal-ion-binding-a-comparison-of-experimental-data-and-td-dft-calculations-for-model-compounds
#20
Mingquan Yan, Xuze Han, Chenyang Zhang
In this study, seven model compounds containing typical functional groups (phenolic and carboxylic groups) present in nature organic matter (NOM) were used to ascertain the nature of the characteristic bands in differential absorbance spectra (DAS) of NOM that are induced by metal ion binding. Some similarities were found between the DAS of the examined model compounds, caffeic acid, ferulic acid, sinapic acid, terephthalic acid, isophthalic acid, esculetin and myricetin and those of NOM. The binding of Cu(II) with carboxylic group might produce two peaks, A1 and A2, while the binding of Cu(II) with phenolic group might produce all four Gaussian peaks, from A1 to A4 displayed in the DAS of NOM...
November 1, 2017: Water Research
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