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https://www.readbyqxmd.com/read/29888220/exploring-the-structural-diversity-in-inhibitors-of-%C3%AE-synuclein-amyloidogenic-folding-aggregation-and-neurotoxicity
#1
Sukanya Das, Tara L Pukala, Scott D Smid
Aggregation of α-Synuclein (αS) protein to amyloid fibrils is a neuropathological hallmark of Parkinson's disease (PD). Growing evidence suggests that extracellular αS aggregation plays a pivotal role in neurodegeneration found in PD in addition to the intracellular αS aggregates in Lewy bodies (LB). Here, we identified and compared a diverse set of molecules capable of mitigating protein aggregation and exogenous toxicity of αSA53T, a more aggregation-prone αS mutant found in familial PD. For the first time, we investigated the αS anti-amyloid activity of semi-synthetic flavonoid 2', 3', 4' trihydroxyflavone or 2-D08, which was compared with natural flavones myricetin and transilitin, as well as such structurally diverse polyphenols as honokiol and punicalagin...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29886836/a-multi-targeted-natural-flavonoid-myricetin-impedes-abnormal-glioblastoma-cell-motility-and-invasiveness-via-suppressing-lamellipodia-and-focal-adhesions-formation
#2
Hua-Fu Zhao, Gang Wang, Chang-Peng Wu, Xiu-Ming Zhou, Jing Wang, Zhong-Ping Chen, Shing-Shun Tony To, Wei-Ping Li
BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive and malignant primary brain tumor characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma, which contribute to tumor recurrence and poor prognosis. Myricetin is a natural flavonoid with potent anti-oxidant, anti-inflammatory and anti-cancer activities, which may serve as a potential and harmless agent for GBM treatment. METHODS: To investigate the anti-glioblastoma effects of myricetin, GBM cells were treated with myricetin alone or in combination with temozolomide...
June 10, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29883721/myricetin-ameliorates-glucocorticoid-induced-osteoporosis-through-the-erk-signaling-pathway
#3
Shuli Fan, Xiang Gao, Peng Chen, Xu Li
Myricetin has been reported to promote osteogenic differentiation and inhibit osteoclastogenesis. The aim of this study was to investigate the potential effects of myricetin on glucocorticoid-induced osteoporosis (GIOP) both in vivo and in vitro. Male Sprague-Dawley (SD) rats were given dexamethasone (DEX, 0.1 mg/kg, s.c.) once daily and myricetin (1 mg/kg or 2.5 mg/kg, i.p.) once every other day for a total of five weeks. Body weight was recorded once a week. Bone mineral density (BMD), the activities or levels of bone turnover markers, and histological changes were assessed...
June 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29851162/flavonoids-inhibit-both-rice-and-sheep-serotonin-n-acetyltransferases-and-reduce-melatonin-levels-in-plants
#4
Kyungjin Lee, Ok Jin Hwang, Russel J Reiter, Kyoungwhan Back
The plant melatonin biosynthetic pathway has been well characterized, but inhibitors of melatonin synthesis have not been well studied. Here, we found that flavonoids potently inhibited plant melatonin synthesis. For example, flavonoids including morin and myricetin significantly inhibited purified, recombinant sheep serotonin N-acetyltransferase (SNAT). Flavonoids also dose-dependently and potently inhibited purified rice SNAT1 and SNAT2. Thus, myricetin (100 μmol/L) reduced rice SNAT1 and SNAT2 activity 7- and 10-fold, respectively, and also strongly inhibited the N-acetylserotonin methyltransferase activity of purified, recombinant rice caffeic acid O-methyltransferase...
May 31, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29784329/health-and-taste-related-compounds-in-strawberries-under-various-irrigation-regimes-and-bio-stimulant-application
#5
Burcak Kapur, Mehmet Ali Sarıdaş, Eser Çeliktopuz, Ebru Kafkas, Sevgi Paydaş Kargı
Strawberry has a unique status within the fruit species in terms of health and taste related compounds. This experimental study concerned the application of a bio-stimulant at various drip irrigation levels (IR125, IR100, IR75 and IR50). The effects of the bio-stimulant (seaweed extract) on the eating quality, i.e., the taste-related (TSS, fructose, glucose, sucrose and citric, malic, l-ascorbic acid), and health-related (antioxidant activity, total phenol, myricetin and quercetin) compounds were studied in two strawberry cultivars...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29772521/myricetin-attenuates-neurodegeneration-and-cognitive-impairment-in-parkinsonism
#6
Vijayraja Dhanraj, Jeyaprakash Karuppaiah, Rengasamy Balakrishnan, Namasivayam Elangovan
Parkinson's disease (PD) is a progressive neurodegenerative disease due to dopaminergic neuron degeneration. It mostly affects the aged population, leads to memory decline and loss of motor coordination. The present study investigates the neuroprotective role of myricetin a flavonol isolated from the brown seaweed Turbinaria ornata in rotenone induced Drosophila model of PD. Rotenone administration led to dopaminergic neuronal degeneration, dopamine depletion, impaired muscular coordination, gait disturbances, memory decline oxidative stress and apoptosis...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29757351/m10-a-novel-derivative-of-myricetin-prevents-ulcerative-colitis-and-colorectal-tumor-through-attenuating-robust-endoplasmic-reticulum-stress
#7
Feng Wang, Zhi-Yu Song, Xian-Jun Qu, Feng Li, Liang Zhang, Wen-Bao Li, Shu-Xiang Cui
Chronic gut inflammation disposes to an increased risk of colitis-associated cancer (CAC). Chemoprevention is an attractive complementary strategy. We aimed to evaluate the chemopreventive effects of M10, a novel derivative of Myricetin, in the murine azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Oral administration of M10 at 50-100 mg/kg once a day for consecutive 12 weeks significantly prevented ulcerative colitis and colorectal tumor. Pathological analysis of intestines showed that M10 reduced the degree of chronic inflammation and prevented the progression of colorectal tumorigenesis...
May 11, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29753067/drug-interaction-study-of-flavonoids-toward-cyp3a4-and-their-quantitative-structure-activity-relationship-qsar-analysis-for-predicting-potential-effects
#8
Yannan Li, Jing Ning, Yan Wang, Chao Wang, Chengpeng Sun, Xiaokui Huo, Zhenlong Yu, Lei Feng, Baojing Zhang, Xiangge Tian, Xiaochi Ma
The high risk of herb-drug interactions (HDIs) mediated by the herbal medicines and dietary supplements which containing abundant flavonoids had become more and more frequent in our daily life. In our study, the inhibition activities of 44 different structures of flavonoids toward human CYPs were systemically evaluated for the first time. According to our results, a remarkable structure-dependent inhibition behavior toward CYP3A4 was observed in vitro. Some flavonoids such as licoflavone (12) and irilone (30) exhibited the selective inhibition toward CYP3 A4 rather than other major human CYPs...
May 9, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29752542/a-computational-investigation-on-the-antioxidant-potential-of-myricetin-3-4-di-o-%C3%AE-l-rhamnopyranoside
#9
Rodrigo A Mendes, Shawan K C Almeida, Iuri N Soares, Cristina A Barboza, Renato G Freitas, Alex Brown, Gabriel L C de Souza
In this work, we present a computational study on the antioxidant potential of myricetin 3,4[Formula: see text]-di-O-α-L-rhamnopyranoside (Compound M). A density functional theory (DFT) approach with the B3LYP and LC-ωPBE functionals and with both the 6-311G(d,p) and 6-311+G(d,p) basis sets was used. The focus of the investigation was on the structural and energetic parameters including both bond dissociation enthalpies (BDEs) and ionization potentials (IPs), which provide information on the potential antioxidant activity...
May 11, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29745443/myricetin-induced-oxidative-stress-suppresses-murine-t-lymphocyte-activation
#10
Javad Ghassemi-Rad, Mahdis Maleki, Allison F Knickle, David W Hoskin
A number of polyphenolic compounds present in fruits and vegetables have the capacity to modulate immune responses; however, the impact of the common plant-derived flavonoid myricetin on T lymphocyte function has not been investigated. We show that myricetin inhibited mouse T lymphocyte activation by bead-immobilized anti-CD3 and anti-CD28 monoclonal antibodies, as indicated by a dose-dependent reduction in cell proliferation and decreased synthesis of interferon-γ, interleukin (IL)-2, IL-4, and IL-17 associated with different T helper cell subsets...
April 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29742465/myricetin-induced-apoptosis-of-triple-negative-breast-cancer-cells-is-mediated-by-the-iron-dependent-generation-of-reactive-oxygen-species-from-hydrogen-peroxide
#11
Allison Knickle, Wasundara Fernando, Anna L Greenshields, H P Vasantha Rupasinghe, David W Hoskin
Myricetin is a dietary phytochemical with anticancer activity; however, the effect of myricetin on breast cancer cells remains unclear. Here, we show that myricetin inhibited the growth of triple-negative breast cancer (TNBC) cells but was less inhibitory for normal cells. The effect of myricetin was comparable to epigallocatechin gallate and doxorubicin, and greater than resveratrol and cisplatin. Myricetin-treated TNBC cells showed evidence of early and late apoptosis/necrosis, which was associated with intracellular reactive oxygen species (ROS) accumulation, extracellular regulated kinase 1/2 and p38 mitogen-activated protein kinase activation, mitochondrial membrane destabilization and cytochrome c release, and double-strand DNA breaks...
May 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29698783/potential-role-of-nucleoside-diphosphate-kinase-in-myricetin-induced-selective-apoptosis-in-colon-cancer-hct-15-cells
#12
Jeong Hyun Lee, Yong Jun Choi, See-Hyoung Park, Myeong Jin Nam
The flavonoid myricetin (MYR) is derived from vegetables and fruits. It has been shown to exert anti-cancer effects in various cell lines; however, the exact mechanism underlying these effects is yet to be elucidated. In this study, we evaluated the anti-cancer effects induced by MYR treatment in colon cancer HCT-15 cells. To detect cell proliferation, we conducted MTT assay and real time-cell electronic sensing (RT-CES). We next performed comet assay and Annexin V and PI staining to detect cellular apoptotic features...
June 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29695037/antioxidative-antiproliferative-and-antimicrobial-activities-of-phenolic-compounds-from-three-myrcia-species
#13
Catarina Dos Santos, Renan S Galaverna, Celio F F Angolini, Vania V A Nunes, Luiz F R de Almeida, Ana L T G Ruiz, João E de Carvalho, Regina M T Duarte, Marta C T Duarte, Marcos N Eberlin
Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid ( M...
April 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29687897/in-vivo-bioavailability-of-polyphenols-from-grape-by-product-extracts-and-effect-on-lipemia-of-normocholesterolemic-wistar-rats
#14
Raul Olivero-David, Maria Belen Ruiz-Roso, Nicola Caporaso, Lourdes Perez-Olleros, Natalia De Las Heras, Vicente Lahera, Baltasar Ruiz-Roso
BACKGROUND: The direct use of phenolic extracts from grape by-products can be useful to formulate functional food to improve consumers' health. The use of phenolic extracts instead of pure polyphenols as an ingredient is relevant in this context. The current work studied the bioavailability and absorption of polyphenols from grape by-product extracts and their health effect on cholesterolemia, by adding the extract (GE) to Wistar rats diet (50 g/kg) in vivo. RESULTS: GE caused the appearance of (+)-catechin, myricetin and quercetic acid in plasma and liver...
April 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29663365/myricetin-treatment-induces-apoptosis-in-canine-osteosarcoma-cells-by-inducing-dna-fragmentation-disrupting-redox-homeostasis-and-mediating-loss-of-mitochondrial-membrane-potential
#15
Hahyun Park, Sunwoo Park, Fuller W Bazer, Whasun Lim, Gwonhwa Song
Canine osteosarcoma is an aggressive primary bone tumor that shows metastasis to distal regions and is associated with a high mortality rate. However, the pathophysiological mechanisms of canine osteosarcoma are not well characterized. In addition, development of prognostic factors and novel therapeutic agents is necessary to efficiently treat osteosarcoma. Therefore, we studied the effects of myricetin, an antioxidant found in berries, nuts, teas, wine, and vegetables, on apoptosis and signal transduction in the canine osteosarcoma cell lines, D-17 and DSN...
September 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29658045/potential-of-borojoa-patinoi-cuatrecasas-water-extract-to-inhibit-nosocomial-antibiotic-resistant-bacteria-and-cancer-cell-proliferation-in-vitro
#16
Clemencia Chaves-López, Donatella Usai, Matthew Gavino Donadu, Annalisa Serio, Robert Tulio González-Mina, Maria Chiara Simeoni, Paola Molicotti, Stefania Zanetti, Antonio Pinna, Antonello Paparella
Borojó (Borojoa patinoi Cuatrec.) is a fruit used in Colombian traditional medicine with supposed antihypertensive, antitumoral, diuretic, healing, immunological, anti-inflammatory and aphrodisiac effects. To explore the relative merits in terms of biological activities of borojó aqueous extract (BAE), we investigated in vitro its antimicrobial activity on nosocomial pathogenic and multidrug resistant (MDR) strains of Pseudomonas aeruginosa (6), Staphylococcus aureus (1) and Candida species (6), as well as its cytotoxicity on human conjunctive Wong-Kilbourne derivative (WKD) cells and Caco-2 cells from heterogeneous human epithelial colorectal adenocarcinoma...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29655718/quantitative-analyses-of-the-bitterness-and-astringency-of-catechins-from-green-tea
#17
Yong-Quan Xu, Ying-Na Zhang, Jian-Xin Chen, Fang Wang, Qi-Zhen Du, Jun-Feng Yin
Bitterness and astringency are two important quality attributes of green tea infusion, and catechins are the main contributor to the bitterness and astringency. The aim of this work was to quantitatively analyse the bitterness and astringency of green tea infusion according to the concentrations of catechins. The concentration-taste curves of catechins showed a pattern that fit the cubic functions, and their R2 values were higher than 0.956. The bitterness of green tea was highly correlated with the concentrations of (-)-epigallocatechin gallate and (-)-epicatechin gallate (ECG) (R2  = 0...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29653427/potential-of-portuguese-vine-shoot-wastes-as-natural-resources-of-bioactive-compounds
#18
Manuela M Moreira, M Fátima Barroso, João Vasconcellos Porto, M J Ramalhosa, Jaroslava Švarc-Gajić, Letícia Estevinho, Simone Morais, Cristina Delerue-Matos
Since annually a high amount of wastes is produced in vine pruning, the aim of this study was to evaluate the potential of vine shoots from two Portuguese grape varieties (Touriga Nacional - TN and Tinta Roriz - TR) to be used as a natural source of phenolic compounds. To reach this goal, three techniques were explored, namely microwave-assisted extraction (MAE), subcritical water extraction (SWE) and conventional extraction (CE). The phenolic composition of the extracts, antioxidant and biological activities were evaluated by spectrophotometry and chromatography...
September 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29620451/flavonoids-from-plinia-cauliflora-mart-kausel-myrtaceae-with-antifungal-activity
#19
Tatiana M Souza-Moreira, Juliana A Severi, Edvânio Ramos Rodrigues, Mayara Ivani de Paula, Jolindo A Freitas, Wagner Vilegas, Rosemeire C L R Pietro
Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi...
April 5, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29602643/lc-ms-analysis-and-cytoprotective-effect-against-the-mercurium-and-aluminium-toxicity-by-bioactive-products-of-psidium-brownianum-mart-ex-dc
#20
Celestina E Sobral-Souza, Ana R P Silva, Nadghia F Leite, José G M Costa, Irwin R A Menezes, Francisco A B Cunha, Larissa A Rolim, Henrique D M Coutinho
This study aimed to verify the chelating, antioxidant and cytoprotective activities of Psidium brownianum Mart. Ex DC against mercury and aluminum. The ethanolic extract, as well as the tannic and flavonoid fractions, were prepared and subjected to liquid chromatography-mass spectrometry analysis. Ferric ion reduction and antioxidant activity measurement using the FRAP method were performed with P. brownianum. After determining the sub-allelopathic doses, germination tests using Lactuca sativa (lettuce) seeds were performed...
March 21, 2018: Journal of Hazardous Materials
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