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https://www.readbyqxmd.com/read/28317253/correlation-between-the-potency-of-flavonoids-for-cytochrome-c-reduction-and-inhibition-of-cardiolipin-induced-peroxidase-activity
#1
Ricardo Lagoa, Alejandro K Samhan-Arias, Carlos Gutierrez-Merino
There are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role. In this work, we show that 7 of 13 flavonoids studied have a capacity to reduce Cyt c similar or higher than ascorbate, the flavonols quercetin, kaempferol and myricetin, flavanol epigallocatechin-gallate, anthocyanidins cyanidin and malvidin, and the flavone luteolin. In contrast, the kaempferol 3(O)- and 3,4'(O)-methylated forms, the flavanone naringenin, and also apigenin and chrysin, had a negligible reducing capacity...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28270518/myricetin-a-potent-approach-for-the-treatment-of-type-2-diabetes-as-a-natural-class-b-gpcr-agonist
#2
Ying Li, Xuemin Zheng, Xiulin Yi, Changxiao Liu, Dexin Kong, Jianning Zhang, Min Gong
The physiologic properties of glucagon-like peptide 1 (GLP-1) make it a potent candidate drug target in the treatment of type 2 diabetes mellitus (T2DM). GLP-1 is capable of regulating the blood glucose level by insulin secretion after administration of oral glucose. The advantages of GLP-1 for the avoidance of hypoglycemia and the control of body weight are attractive despite its poor stability. The clinical efficacies of long-acting GLP-1 derivatives strongly support discovery pursuits aimed at identifying and developing orally active, small-molecule GLP-1 receptor (GLP-1R) agonists...
March 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28262394/the-in-vitro-anthelmintic-properties-of-browse-plant-species-against-haemonchus-contortus-is-determined-by-the-polyphenol-content-and-composition
#3
G Mengistu, H Hoste, M Karonen, J-P Salminen, W H Hendriks, W F Pellikaan
The aims of the present study were to (a) evaluate the anthelmintic activity of 10 East African browse plant extracts, (b) examine their role in inhibition of Haemonchus contortus larval exsheathment, (c) establish relationship between inhibition of larval exsheathment and browse plant extract polyphenol composition. Acetone/water (70/30%) extracts of air dried leaves of Acacia etbaica, Cadaba farinosa, Capparis tomentosa, Dichrostachys cinerea, Dodonaea angustifolia, Euclea racemosa, Maerua angolensis, Maytenus senegalensis, Rhus natalensis and Senna singueana were used...
December 31, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/28259640/structural-basis-for-inhibition-of-17%C3%AE-hydroxysteroid-dehydrogenases-by-phytoestrogens-the-case-of-fungal-17%C3%AE-hsdcl
#4
Alberto Cassetta, Jure Stojan, Ivet Krastanova, Katja Kristan, Mojca Brunskole Švegelj, Doriano Lamba, Tea Lanišnik Rižner
Phytoestrogens are plant-derived compounds that functionally and structurally mimic mammalian estrogens. Phytoestrogens have broad inhibitory activities toward several steroidogenic enzymes, such as the 17β-hydroxysteroid dehydrogenases (17β-HSDs), which modulate the biological potency of androgens and estrogens in mammals. However, to date, no crystallographic data are available to explain phytoestrogens binding to mammalian 17β-HSDs. NADP(H)-dependent 17β-HSD from the filamentous fungus Cochliobolus lunatus (17β-HSDcl) has been the subject of extensive biochemical, kinetic and quantitative structure-activity relationship studies that have shown that the flavonols are the most potent inhibitors...
March 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28250661/antifungal-activity-of-hydroalcoholic-extract-of-chrysobalanus-icaco-against-oral-clinical-isolates-of-candida-species
#5
João Paulo Bastos Silva, Ana Regina Maués Noronha Peres, Thiago Portal Paixão, Andressa Santa Brígida Silva, Ana Cristina Baetas, Wagner Luiz Ramos Barbosa, Marta Chagas Monteiro, Marcieni Ataíde Andrade
BACKGROUND: Chrysobalanus icaco is a medicinal plant commonly used to treat fungal infections in Brazilian Amazonian region. OBJECTIVE: This work aimed to evaluate the antifungal activity of the hydroalcoholic extract of C. icaco (HECi) against oral clinical isolates of Candida spp. and to determine the pharmacognostic parameters of the herbal drug and the phytochemical characteristics of HECi. MATERIALS AND METHODS: The pharmacognostic characterization was performed using pharmacopoeial techniques...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28243615/dataset-on-absorption-spectra-and-bulb-concentration-of-phenolic-compounds-that-may-interfere-with-onion-pyruvate-determinations
#6
Vanesa H Beretta, Florencia Bannoud, Marina Insani, Claudio R Galmarini, Pablo F Cavagnaro
We present data on absorption spectra (400-540 nm) and concentration of phenolic compounds quercetin, myricetin, kaempferol, rutin, catechin, epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), in yellow, red and white onions. These data are related to the article entitled "Variability in spectrophotometric pyruvate analyses for predicting onion pungency and nutraceutical value" (Beretta et al., 2017) [1]. Given the relevance of pyruvate determinations for estimating onion pungency and functional value, it is important to identify compounds that can interfere with pyruvate determinations when using two previously published analytical procedures, namely Schwimmer and Weston (1961) (SW) [2] and Anthon and Barret (2002) (AB) [3], which are based on spectrophotometry and light-absorbance at 420 nm and 515 nm, respectively...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28220704/functional-characterization-of-a-new-tea-camellia-sinensis-flavonoid-glycosyltransferase
#7
Xianqian Zhao, Peiqiang Wang, Mingzhuo Li, Yeru Wang, Xiaolan Jiang, Lilan Cui, Yumei Qian, Juhua Zhuang, Liping Gao, Tao Xia
Tea (Camellia sinensis) is an important commercial crop, in which the high content of flavonoids provides health benefits. A flavonoid glycosyltransferase (CsUGT73A20), belonging to cluster IIIa, was isolated from tea plant. The recombinant CsUGT73A20 in Escherichia coli exhibited a broad substrate tolerance toward multiple flavonoids. Among them, kaempferol was the optimal substrate compared to quercetin, myricetin, naringenin, apigenin, and kaempferide. However, no product was detected when UDP-galactose was used as the sugar donor...
March 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28218702/phytochemical-study-of-tapirira-guianensis-leaves-guided-by-vasodilatory-and-antioxidant-activities
#8
Amélia M G Rodrigues, Denise O Guimarães, Tatiana U P Konno, Luzineide W Tinoco, Thiago Barth, Fernando A Aguiar, Norberto P Lopes, Ivana C R Leal, Juliana M Raimundo, Michelle F Muzitano
The aim of this research was to perform a phytochemical study of the methanol leaves extract of T. guianensis (MET) guided by vasodilatory and antioxidant activities. The chemical profile of MET and the ethyl acetate fraction (EA fraction) was determined by HPLC-UV-MS and EA fraction guided fractionation by reverse-phase chromatography. The vasorelaxant effects of MET, fractions, sub-fractions and constituents were assessed on rat aorta pre-contracted with phenylephrine. Antioxidant activity was evaluated by using a DPPH assay...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28197195/myricetin-protects-hippocampal-ca3-pyramidal-neurons-and-improves-learning-and-memory-impairments-in-rats-with-alzheimer-s-disease
#9
Matin Ramezani, Niloufar Darbandi, Fariba Khodagholi, Azam Hashemi
There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28185989/enhanced-oral-bioavailability-of-docetaxel-in-rats-combined-with-myricetin-in-situ-and-in-vivo-evidences
#10
Tianyun Hao, Yunni Ling, Meijuan Wu, Yajing Shen, Yu Gao, Shujun Liang, Yuan Gao, Shuai Qian
The purpose of this study was to investigate the effect of myricetin on the pharmacokinetics of docetaxel in rats. In comparison to oral docetaxel alone (40mg/kg), the bioavailability of docetaxel could be significantly enhanced by 1.6-2.4-fold via oral co-administration with various flavonoids (apigenin, naringenin, baicalein, quercetin and myricetin) at a dosage of 10mg/kg, and myricetin showed the highest bioavailability improvement. Further pharmacokinetic studies demonstrated that the presence of myricetin (5-20mg/kg) enhanced both Cmax and AUC of docetaxel with the highest Cmax (162ng/mL, 2...
April 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28178217/flavonoid-composition-and-antitumor-activity-of-bee-bread-collected-in-northeast-portugal
#11
Filipa Sobral, Ricardo C Calhelha, Lillian Barros, Montserrat Dueñas, Andreia Tomás, Celestino Santos-Buelga, Miguel Vilas-Boas, Isabel C F R Ferreira
Bee bread (BB) is a fermented mixture of plant pollen, honey, and bee saliva that worker bees use as food for larvae, and for young bees to produce royal jelly. In the present study, five BB samples, collected from Apis mellifera iberiensis hives located in different apiaries near Bragança, in the northeast region of Portugal, and one BB commercial sample were characterized by high-performance liquid chromatography coupled to a diode array detector and electrospray mass spectrometry (HPLC-DAD-ESI/MS) in terms of phenolic compounds, such as flavonoid glycoside derivatives...
February 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28165408/response-surface-methodology-optimization-of-ultrasonic-assisted-extraction-of-acer-truncatum-leaves-for-maximal-phenolic-yield-and-antioxidant-activity
#12
Lingguang Yang, Peipei Yin, Hang Fan, Qiang Xue, Ke Li, Xiang Li, Liwei Sun, Yujun Liu
This study is the first to report the use of response surface methodology to improve phenolic yield and antioxidant activity of Acer truncatum leaves extracts (ATLs) obtained by ultrasonic-assisted extraction. The phenolic composition in ATLs extracted under the optimized conditions were characterized by UPLC-QTOF-MS/MS. Solvent and extraction time were selected based on preliminary experiments, and a four-factors-three-levels central composite design was conducted to optimize solvent concentration (X₁), material-to-liquid ratio (X₂), ultrasonic temperature (X₃) and power (X₄) for an optimal total phenol yield (Y₁) and DPPH• antioxidant activity (Y₂)...
February 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28152668/evaluation-of-the-antioxidant-activity-of-betula-pendula-leaves-extract-and-its-effects-on-model-foods
#13
Nurul Aini Mohd Azman, Monika Skowyra, Kwestan Muhammad, María Gabriela Gallego, Maria Pilar Almajano
CONTEXT: Betula pendula Roth (Betulaceae) exhibits many pharmacological activities in humans including anticancer, antibacterial, and antiviral effects. However, the antioxidant activity of BP towards lipid degradation has not been fully determined. OBJECTIVE: The BP ethanol and methanol extracts were evaluated to determine antioxidant activity by an in vitro method and lyophilized extract of BP was added to beef patties to study oxidative stability. MATERIALS AND METHODS: Antioxidant activities of extracts of BP were determined by measuring scavenging radical activity against methoxy radical generated by Fenton reaction 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (TEAC) radical cation, the oxygen radical absorbance capacity (ORAC) and the ferric reducing antioxidant power (FRAP) assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28125218/identification-of-a-ligand-binding-site-on-the-staphylococcus-aureus-dnag-primase-c-terminal-domain
#14
Jonathan Catazaro, Jessica Periago, Matthew D Shortridge, Bradley Worley, Andrew Kirchner, Robert Powers, Mark A Griep
The interface between the DnaG primase C-terminal domain (CTD) and the N-terminal domain of DnaB helicase is essential for bacterial DNA replication because it allows coordinated priming of DNA synthesis at the replication fork while the DNA is being unwound. Because these two proteins are conserved in all bacteria and distinct from those in eukaryotes, their interface is an attractive antibiotic target. To learn more about this interface, we determined the solution structure and dynamics of the DnaG primase CTD from Staphylococcus aureus, a medically important bacterial species...
February 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/28115379/differential-gene-expression-on-lactobacillus-plantarum-wcfs1-in-response-to-phenolic-compounds-unravels-new-genes-involved-in-tannin-degradation
#15
Inés Reverón, Natalia Jiménez, José Antonio Curiel, Elena Peñas, Félix López de Felipe, Blanca de Las Rivas, Rosario Muñoz
Lactobacillus plantarum is a lactic acid bacterium able to degrade food tannins by the subsequent action of tannase and gallate decarboxylase enzymes. In the L. plantarum genome the gene encoding the catalytic subunit of gallate decarboxylase (lpdC or lp_2945) is only 6.5 kb distant relative to the gene encoding inducible tannase (tanBLp or lp_2956). This genomic context suggests a concomitant activity and regulation of both enzymatic activities. Reverse transcription analysis revealed that B (lpdB or lp_0271) and D (lpdD or lp_0272) subunits of gallate decarboxylase are cotranscribed, whereas C subunit (lpdC or lp_2945) is cotranscribed with a transport protein (gacP or lp_2943)...
January 23, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28114854/gastrointestinal-stability-of-dihydromyricetin-myricetin-and-myricitrin-an-in-vitro-investigation
#16
Dong Xiang, Chen-Guang Wang, Wen-Qing Wang, Chun-Yang Shi, Wei Xiong, Meng-Die Wang, Jian-Guo Fang
The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin (MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors that may influence the degradation rate of theses flavonoids were evaluated, including pH and the presence of pepsin and pancreatin enzymes. We found that GI stability followed the order of MYT > DMY > MYR. These flavonoids were stable in simulated gastric fluids and buffer solutions (pH 1.2), but encountered a pseudo-first-order kinetic degradation in simulated intestinal fluids and buffer solutions (pH 6...
January 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28107794/a-study-on-the-gc-ms-analysis-of-bioactive-components-and-pancreato-protective-effect-of-methanolic-extract-of-brassica-oleracea-l-var-botrytis
#17
Sadanandan Rajapriya, Arumugam Geetha, Kavasseri Ganesan Kripa
The ever-increasing problem of pancreatitis due to alcohol abuse demands evaluation of novel drugs of plant origin. This study explores the therapeutic effects of the methanolic extract of Brassica oleraceae (MEBO) on ethanol and cerulein induced pancreatitis in rats. The MEBO was subjected to GC-MS and HPLC analysis. Male albino Wistar rats were divided into various groups, fed with alcohol (36% of total calories for 5 weeks) and cerulein (20 μg/kg b.wt i.p, weekly thrice for last three weeks) with or without MEBO (40 mg/kg b...
January 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28097162/antioxidant-activity-of-polyphenolic-myricetin-in-vitro-cell-free-and-cell-based-systems
#18
Abolfazl Barzegar
Myricetin (Myc) is one of the most important flavonoids in diet due to its abundance in foods with the highest antioxidant activity. The antioxidant activity of Myc was studied in cell-free and cell-based systems to evaluate the ROS protection efficiency of Myc. The studies were based on the assessment of reducing power of Myc according to ferric ion reduction and intracellular ROS level measurement by assaying the cellular fluorescence intensity using dichlorodihydrofluorescein (DCF) probe as an indicator for ROS in cells...
June 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28091822/does-the-growth-differentiation-balance-hypothesis-explain-allocation-to-secondary-metabolites-in-combretum-apiculatum-an-african-savanna-woody-species
#19
Dawood Hattas, Peter F Scogings, Riitta Julkunen-Tiitto
The growth differentiation balance hypothesis (GDBH) provides a framework that predicts a trade-off between costs of secondary metabolites (SMs) relative to the demand for photosynthate by growth. However, this hypothesis was developed using empirical evidence from plant species in northern boreal and temperate systems, leaving its applicability to species under different abiotic and biotic conditions questionable and generalizations problematic. The objective of this study was to investigate whether the GDBH explains allocation to SMs in the deciduous African savanna woody species C...
January 14, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28064632/protective-effects-of-apigenin-and-myricetin-against-cisplatin-induced-nephrotoxicity-in-mice
#20
Samar M Hassan, Marwa M Khalaf, Sawsan A Sadek, Amira M Abo-Youssef
CONTEXT: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by nephrotoxicity. OBJECTIVE: This study aims to investigate the nephroprotective role of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. MATERIALS AND METHODS: Adult female Wistar Albino mice were divided into eight groups (n = 8). Group I served as normal control. Groups II, III and IV received apigenin (3 mg/kg, i.p.), myricetin (3 mg/kg, i...
December 2017: Pharmaceutical Biology
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