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https://www.readbyqxmd.com/read/28097162/antioxidant-activity-of-polyphenolic-myricetin-in-vitro-cell-free-and-cell-based-systems
#1
Abolfazl Barzegar
Myricetin (Myc) is one of the most important flavonoids in diet due to its abundance in foods with the highest antioxidant activity. The antioxidant activity of Myc was studied in cell-free and cell-based systems to evaluate the ROS protection efficiency of Myc. The studies were based on the assessment of reducing power of Myc according to ferric ion reduction and intracellular ROS level measurement by assaying the cellular fluorescence intensity using dichlorodihydrofluorescein (DCF) probe as an indicator for ROS in cells...
June 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28091822/does-the-growth-differentiation-balance-hypothesis-explain-allocation-to-secondary-metabolites-in-combretum-apiculatum-an-african-savanna-woody-species
#2
Dawood Hattas, Peter F Scogings, Riitta Julkunen-Tiitto
The growth differentiation balance hypothesis (GDBH) provides a framework that predicts a trade-off between costs of secondary metabolites (SMs) relative to the demand for photosynthate by growth. However, this hypothesis was developed using empirical evidence from plant species in northern boreal and temperate systems, leaving its applicability to species under different abiotic and biotic conditions questionable and generalizations problematic. The objective of this study was to investigate whether the GDBH explains allocation to SMs in the deciduous African savanna woody species C...
January 14, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28064632/protective-effects-of-apigenin-and-myricetin-against-cisplatin-induced-nephrotoxicity-in-mice
#3
Samar M Hassan, Marwa M Khalaf, Sawsan A Sadek, Amira M Abo-Youssef
CONTEXT: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by nephrotoxicity. OBJECTIVE: This study aims to investigate the nephroprotective role of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. MATERIALS AND METHODS: Adult female Wistar Albino mice were divided into eight groups (n = 8). Group I served as normal control. Groups II, III and IV received apigenin (3 mg/kg, i.p.), myricetin (3 mg/kg, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28064082/novel-flavonol-analogues-as-potential-inhibitors-of-jmjd3-histone-demethylase-a-study-based-on-molecular-modelling
#4
Sanchari Basu Mallik, Aravinda Pai, Rekha R Shenoy, B S Jayashree
Epigenetic modulation of gene expression has drawn enormous attention among researchers globally in the present scenario. Since their discovery, Jmj-C histone demethylases were identified as useful markers in understanding the role of epigenetics in inflammatory conditions and in cancer as well. This has created arousal of interest in search of suitable candidates. Potential inhibitors from various other scaffolds such as hydroxyquinolines, hydroxamic acids and triazolopyridines have already been identified and reported...
December 13, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28044154/biofunctional-metal-phenolic-films-from-dietary-flavonoids
#5
Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso
We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules, overcoming the poor water solubility of free flavonoids. Films formed from quercetin, myricetin, luteolin and fisetin show radical scavenging activity, a renowned feature of their parent flavonoids, and can be reused over multiple cycles. These films are expected to have potential applications in the pharmaceutical and food industries.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28040469/the-chilean-superfruit-black-berry-aristotelia-chilensis-elaeocarpaceae-maqui-as-mediator-in-inflammation-associated-disorders
#6
Carlos L Cespedes, Natalia Pavon, Mariana Dominguez, Julio Alarcon, Cristian Balbontin, Isao Kubo, Mohammed El-Hafidi, Jose G Avila
The effects of phytochemicals occurred in fractions and extracts of fruits of "Maqui-berry" (Aristotelia chilensis), on the expression of cyclooxygenase-2 (COX-2), inducible-nitric oxide synthases (iNOS) and the production of proinflammatory mediators were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW-264 cells, as well as their antioxidant activities. The MeOH extract (A), acetone/methanol extract (B), fractions F3, F4, subfractions (SF4-SF6, SF7, SF8-SF10, SF11-SF15, SF16-SF20), quercetin, gallic acid, luteolin, myricetin, mixtures M1, M2 and M3 exhibited potent anti-inflammatory and antioxidant activities...
December 28, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28039815/differential-phenolic-production-in-leaves-of-vitis-vinifera-cv-alvarinho-affected-with-esca-disease
#7
Marta R M Lima, Mafalda L Felgueiras, Ana Cunha, Gisela Chicau, Federico Ferreres, Alberto C P Dias
Esca is a destructive disease of complex etiology affecting grapevines worldwide. A major constraint to the study and control of esca is that the disease is not diagnosed until external leaf and/or fruit symptoms are visible; however external symptoms usually appear several years after infection onset. We studied the phenolic content of V. vinifera cv. Alvarinho leaves using high performance liquid chromatography-diode array detection-mass spectrometry (HPLC-DAD-MS)/LC-MS. Leaves from affected cordons with and without visible symptoms (diseased and apparently healthy leaves, respectively) and leaves from asymptomatic cordons (healthy leaves) were analyzed...
December 24, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28018403/comparative-analysis-of-phenolic-compound-characterization-and-their-biosynthesis-genes-between-two-diverse-bread-wheat-triticum-aestivum-varieties-differing-for-chapatti-unleavened-flat-bread-quality
#8
Monica Sharma, Rajat Sandhir, Anuradha Singh, Pankaj Kumar, Ankita Mishra, Sanjay Jachak, Sukhvinder P Singh, Jagdeep Singh, Joy Roy
Phenolic compounds (PCs) affect the bread quality and can also affect the other types of end-use food products such as chapatti (unleavened flat bread), now globally recognized wheat-based food product. The detailed analysis of PCs and their biosynthesis genes in diverse bread wheat (Triticum aestivum) varieties differing for chapatti quality have not been studied. In this study, the identification and quantification of PCs using UPLC-QTOF-MS and/or MS/MS and functional genomics techniques such as microarrays and qRT-PCR of their biosynthesis genes have been studied in a good chapatti variety, "C 306" and a poor chapatti variety, "Sonalika...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27983763/the-common-dietary-flavonoid-myricetin-attenuates-liver-fibrosis-in-carbon-tetrachloride-treated-mice
#9
Yan Geng, Qing Sun, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Jin-Song Shi, Zheng-Hong Xu
SCOPE: Myricetin is found in most berries, vegetables, and various medicinal herbs, which has been reported to possess various bio-activities. However, the role of myricetin on liver fibrosis remains to be elucidated. METHODS AND RESULTS: Hepatic stellate cell (HSC) line CFSC-8B was stimulated by transforming growth factor-β1 (TGF-β1) or Platelet-derived growth factor-BB (PDGF-BB) to induce liver fibrosis in vitro. The results showed that myricetin significantly ameliorated TGF-β1 or PDGF-BB induced HSCs activation, cell migration, and extracellular matrix (ECM) production, blocked TGF-β1 induced phosphorylation of Smad2, P38, extracellular signal-regulated kinase (ERK) and Protein kinase B (AKT), and down-regulated PDGF-BB stimulated phosphorylation of ERK and AKT in HSCs in a dose-dependent manner...
December 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27979208/prediction-of-chinese-green-tea-ranking-by-metabolite-profiling-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-q-tof-ms
#10
Jin Jing, Yuanzhi Shi, Qunfeng Zhang, Jie Wang, Jianyun Ruan
Metabolomics profiling provides comprehensive picture of the chemical composition in teas therefore may be used to assess tea quality objectively and reliably. In the present experiment, water and methanol extracts of green teas from China were analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) with the objectives to establish a model for quality prediction and to identify potential marker metabolites. The blindly evaluated sensory score of green teas was predicted with excellent power (R(2)=0...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27979130/myricetin-inhibits-the-generation-of-superoxide-anion-by-reduced-form-of-xanthine-oxidase
#11
Cen Zhang, Guowen Zhang, Yijing Liao, Deming Gong
Myricetin, a plant-derived flavonol, was found to inhibit the formation of uric acid in a mixed-type manner with IC50 value of (8.66±0.03)×10(-6)molL(-1) and more potently inhibit the generation of superoxide anion (O2(-)) catalysed by xanthine oxidase (XOD) with IC50 value of (4.55±0.02)×10(-6)molL(-1). Inhibiting O2(-) generation by myricetin may be attributed to the reduced form of XOD with a substantially higher reduction potential for FADH/FADH2 couple. Moreover, molecular docking verified that myricetin bound to the site around isoalloxazine ring in the flavin adenine dinucleotide (FAD) domain to block the diffusion of O2(-) out of the FAD site, resulting in the transfer of another electron from FADH2 to O2(-) to form hydrogen peroxide...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973423/regressive-effect-of-myricetin-on-hepatic-steatosis-in-mice-fed-a-high-fat-diet
#12
Shu-Fang Xia, Guo-Wei Le, Peng Wang, Yu-Yu Qiu, Yu-Yu Jiang, Xue Tang
Myricetin is an effective antioxidant in the treatment of obesity and obesity-related metabolic disorders. The objective of this study was to explore the regressive effect of myricetin on pre-existing hepatic steatosis induced by high-fat diet (HFD). C57BL/6 mice were fed either a standard diet or a HFD for 12 weeks and then half of the mice were treated with myricetin (0.12% in the diet, w/w) while on their respective diets for further 12 weeks. Myricetin treatment significantly alleviated HFD-induced steatosis, decreased hepatic lipid accumulation and thiobarbituric acid reactive substance (TBARS) levels, and increased antioxidative enzyme activities, including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities...
December 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27960275/phenolics-of-selected-cranberry-genotypes-vaccinium-macrocarpon-ait-and-their-antioxidant-efficacy
#13
Gihan Abeywickrama, Samir C Debnath, Priyatharini Ambigaipalan, Fereidoon Shahidi
Free, esterified, and bound phenolic fractions of berries from five different cranberry genotypes and two market samples were evaluated for their total phenolic, flavonoid, and monomeric anthocyanin contents as well as their antioxidant efficacy using TEAC, ORAC, DPPH radical, reducing power, and ferrous ion chelation capacity assays. HPLC-MS/MS analysis was performed for two of the rich sources (Pilgrim and wild clone NL2) of phenolics and high antioxidant activity. Among the genotypes, Pilgrim showed the highest phenolic and flavonoid contents and wild clones NL3 and NL2 showed the highest monomeric anthocyanin and proanthocyanidin content, respectively...
December 14, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27941619/black-crowberry-empetrum-nigrum-l-flavonoids-and-their-health-promoting-activity
#14
REVIEW
Tunde Jurikova, Jiri Mlcek, Sona Skrovankova, Stefan Balla, Jiri Sochor, Mojmir Baron, Daniela Sumczynski
Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (Empetrum nigrum L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27937124/antioxidant-anti-inflammatory-and-anti-septic-potential-of-phenolic-acids-and-flavonoid-fractions-isolated-from-lolium-multiflorum
#15
Ki-Choon Choi, Young-Ok Son, Jung-Min Hwang, Beom-Tae Kim, Minseon Chae, Jeong-Chae Lee
CONTEXT: Interest has recently renewed in using Lolium multiflorum Lam. (Poaceae) (called Italian ryegrass; IRG) silage as an antioxidant and anti-inflammatory diet. OBJECTIVE: This study investigated the antioxidant, anti-inflammatory and anti-septic potential of IRG silage and identified the primary components in IRG active fractions. MATERIALS AND METHODS: Total 16 fractions were separated from the chloroform-soluble extract of IRG aerial part using Sephadex LH-20 column before HPLC analysis...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27916965/pathway-analysis-and-metabolites-identification-by-metabolomics-of-etiolation-substrate-from-fresh-cut-chinese-water-chestnut-eleocharis-tuberosa
#16
Yi-Xiao Li, Yong-Gui Pan, Feng-Ping He, Meng-Qi Yuan, Shang-Bin Li
Fresh-cut Chinese water chestnuts (CWC) turn yellow after being peeled, reducing their shelf life and commercial value. Metabolomics, the systematic study of the full complement of small molecular metabolites, was useful for clarifying the mechanism of fresh-cut CWC etiolation and developing methods to inhibit yellowing. In this study, metabolic alterations associated with etiolation at different growth stages (0 day, 2 days, 3 days, 4 days, 5 days) from fresh-cut CWC were investigated using LC-MS and analyzed by pattern recognition methods (principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal projection to latent structures-discriminant analysis (OPLS-DA))...
December 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27896020/identification-of-phenolic-secondary-metabolites-from-schotia-brachypetala-sond-fabaceae-and-demonstration-of-their-antioxidant-activities-in-caenorhabditis-elegans
#17
Mansour Sobeh, Esraa ElHawary, Herbenya Peixoto, Rola M Labib, Heba Handoussa, Noha Swilam, Ahmed H El-Khatib, Farukh Sharapov, Tamer Mohamed, Sonja Krstin, Michael W Linscheid, Abdel Nasser Singab, Michael Wink, Nahla Ayoub
BACKGROUND: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alcohol extract from S. brachypetala leaves (SBE) using LC/HRESI/MS/MS and NMR and prove their antioxidant capabilities using novel methods. METHODS: In vitro assays; DPPH, TEAC persulfate decolorizing kinetic and FRAP assays, and in vivo assays: Caenorhabditis elegans strains maintenance, Intracellular ROS in C...
2016: PeerJ
https://www.readbyqxmd.com/read/27885509/inhibitory-effect-of-flavonoids-against-ns2b-ns3-protease-of-zika-virus-and-their-structure-activity-relationship
#18
Hee-Jung Lim, Thi Thanh Hanh Nguyen, Nahyun M Kim, Jun-Seong Park, Tae-Su Jang, Doman Kim
OBJECTIVES: To determine the inhibitory activities of flavonoids against NS2B-NS3 protease of ZIKA virus (ZIKV NS2B-NS3(pro)) expressed in Escherichia coli BL21 (DE3) and their structure activity relationship. RESULTS: ZIKV NS2B-NS3(pro) was expressed in E. coli BL21(DE3) as a 35 kDa protein. It had a K m of 26 µM with the fluorogenic peptide Dabcyl-KTSAVLQSGFRKME-Edan. The purified ZIKV NS2B-NS3(pro) was used for inhibition and kinetic assays to determine the activities of 22 polyphenol compounds...
November 24, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27877156/a-chitosan-coating-containing-essential-oil-from-origanum-vulgare-l-to-control-postharvest-mold-infections-and-keep-the-quality-of-cherry-tomato-fruit
#19
Tainá A Barreto, Sonalle C A Andrade, Janeeyre F Maciel, Narciza M O Arcanjo, Marta S Madruga, Bruno Meireles, Ângela M T Cordeiro, Evandro L Souza, Marciane Magnani
The efficacy of an edible chitosan coating (CHI; 4 mg/mL) and Origanum vulgare L. essential oil (OVEO; 1.25 μL/mL) for maintaining the quality of cherry tomato fruit during storage at room (25°C; 12 days) and cold (12°C; 24 days) temperatures was assessed. CHI and OVEO in combination showed in vitro fungicidal effects against R. stolonifer and Aspergillus niger. CHI-OVEO coating reduced the incidence of black mold and soft rot caused by these fungi in artificially contaminated cherry tomato fruit during storage at both temperatures...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27866749/inter-population-and-inter-organ-distribution-of-the-main-polyphenolic-compounds-of-epilobium-angustifolium
#20
Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen
Rosebay willowherb (Epilobium angustifolium) contains large amounts of polyphenolic compounds, including tellimagrandin I-based oligomeric ellagitannins (ETs). The aim of this study was to assess the interpopulational and inter-organ variability of the polyphenol fingerprint of E. angustifolium. Seven ETs, 11 flavonol glycosides and neochlorogenic acid were quantified by UHPLC-DAD-ESI-QqQ-MS in the leaves, flowers and stem parts of plants from 10 populations. Total polyphenol content of leaves and flowers ranged from 150 to 200 mg/g dry wt, of which 90% was constituted by dimeric to heptameric ETs...
February 2017: Phytochemistry
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