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https://www.readbyqxmd.com/read/28073097/moringa-oleifera-a-species-with-potential-analgesic-and-anti-inflammatory-activities
#1
Claudia Lizbeth Martínez-González, Laura Martínez, Efraín J Martínez-Ortiz, María Eva González-Trujano, Myrna Déciga-Campos, Rosa Ventura-Martínez, Irene Díaz-Reval
Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents' nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30-300mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068633/polyphenol-rich-ethanolic-extract-from-boerhavia-diffusa-l-mitigates-angiotensin-ii-induced-cardiac-hypertrophy-and-fibrosis-in-rats
#2
Prathapan A, Mathews V Varghese, Abhilash S, Salin Raj P, Anil K Mathew, Anupama Nair, R Harikumaran Nair, Raghu K G
Boerhavia diffusa is a renowned edible medicinal plant extensively used against different ailments including heart diseases in the traditional system of medicine in several countries. The present study aims to evaluate the therapeutic efficacy of ethanolic extract of Boerhavia diffusa (BDE) on cardiac hypertrophy and fibrosis induced by angiotensin II (Ang II) in male wistar rats and to identify the active components present in it. A substantial increase of hypertrophy markers such as cardiac mass index, concentration of ANP and BNP, cardiac injury markers like CK-MB, LDH and SGOT, has been observed in hypertrophied groups whereas BDE treatment attenuated these changes when compared to hypertrophied rats...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067837/kaempferol-and-chrysin-synergies-to-improve-septic-mice-survival
#3
Omar A Harasstani, Chau Ling Tham, Daud A Israf
Previously, we reported the role of synergy between two flavonoids-namely, chrysin and kaempferol-in inhibiting the secretion of a few major proinflammatory mediators such as tumor necrosis factor-alpha (TNF-α), prostaglandin E₂ (PGE₂), and nitric oxide (NO) from lipopolysaccharide (LPS)-induced RAW 264.7 cells. The present study aims to evaluate the effects of this combination on a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Severe sepsis was induced in male ICR mice (n = 7) via the CLP procedure...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28067836/alkaloids-and-phenolic-compounds-from-sida-rhombifolia-l-malvaceae-and-vasorelaxant-activity-of-two-indoquinoline-alkaloids
#4
Otemberg Souza Chaves, Yanna Carolina Ferreira Teles, Matheus Morais de Oliveira Monteiro, Leônidas das Graças Mendes Junior, Maria de Fátima Agra, Valdir de Andrade Braga, Tânia Maria Sarmento Silva, Maria de Fátima Vanderlei de Souza
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9)...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28066105/antifertility-activity-of-thevetia-peruviana-pers-k-schum-leaf-in-female-sprague-dawley-rat
#5
Jhuma Samanta, Snehendu Bhattacharya, Avtar C Rana
OBJECTIVES: Thevetia peruviana (Pers.) K. Schum. (Apocynaceae) is known to possess cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside. Traditionally, T. peruviana leaves are used as abortifacient. The aim of the present study is to evaluate antifertility potential of T. peruviana leaves. SUBJECTS AND METHODS: Cardiac glycoside freed leaves of T. peruviana were extracted with methanol using maceration method. The dried cardiac glycoside-free methanolic extract of T...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28056421/capparis-spinosa-leaves-extract-source-of-bioantioxidants-with-nephroprotective-and-hepatoprotective-effects
#6
Nizar Tlili, Anouar Feriani, Ezzeddine Saadoui, Nizar Nasri, Abdelhamid Khaldi
Capparis spinosa, Capparidaceae, is largely distributed all over the Mediterranean Basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. The aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of Capparis spinosa leaves (MECS) associated with its phytochemical content. The levels of total phenolics, flavonoids and condensed tannins were 23.37mgGAE/g, 9.05mgQE/g and 9.35mgTAE/g, respectively. HPLC analysis revealed nine compounds, namely rutin, resveratrol, coumarin, epicatechin, luteolin, catechin, kaempferol, vanillic acid and gallic acid...
January 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28051114/novel-therapeutics-identification-for-fibrosis-in-renal-allograft-using-integrative-informatics-approach
#7
Li Li, Ilana Greene, Benjamin Readhead, Madhav C Menon, Brian A Kidd, Andrew V Uzilov, Chengguo Wei, Nimrod Philippe, Bernd Schroppel, John Cijiang He, Rong Chen, Joel T Dudley, Barbara Murphy
Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF/TA. We applied a meta-analysis approach on IF/TA molecular datasets in Gene Expression Omnibus to identify a robust 85-gene signature, which was used for computational drug repurposing analysis. Among the top ranked compounds predicted to be therapeutic for IF/TA were azathioprine, a drug to prevent acute rejection in renal transplantation, and kaempferol and esculetin, two drugs not previously described to have efficacy for IF/TA...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043032/kaempferol-slows-intervertebral-disc-degeneration-by-modifying-lps-induced-osteogenesis-adipogenesis-imbalance-and-inflammation-response-in-bmscs
#8
Jun Zhu, Haoyu Tang, Zhenhua Zhang, Yong Zhang, Chengfeng Qiu, Ling Zhang, Pinge Huang, Feng Li
Intervertebral disc (IVD) degeneration is a common disease that represents a significant cause of socio-economic problems. Bone marrow-derived mesenchymal stem cells (BMSCs) are a potential autologous stem cell source for the nucleus pulposus regeneration. Kaempferol has been reported to exert protective effects against both osteoporosis and obesity. This study explored the effect of kaempferol on BMSCs differentiation and inflammation. The results demonstrated that kaempferol did not show any cytotoxicity at concentrations of 20, 60 and 100μM...
December 30, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/28040655/hierarchical-identification-of-bioactive-components-in-a-medicinal-herb-by-preparative-high-performance-liquid-chromatography-and-selective-knock-out-strategy
#9
Cheng Qu, Lin-Yan Wang, Hang Lin, Er-Xin Shang, Yu-Ping Tang, Shi-Jun Yue, Yi Jin, Wei-Wei Tao, Shao-Ping Li, Yong-Qing Hua, Pei Liu, Shu-Lan Su, Huiping Zhou, Da-Wei Qian, Jin-Ao Duan
A novel and generally applicable approach was established to hierarchically identify the bioactive components of a medicinal herb by preparative high-performance liquid chromatography (prep-HPLC) and a selective knock-out strategy. In this study, the targeted components of an herbal medicine were separated and knocked out using prep-HPLC. Subsequently, the contributions of the different target components to the overall effect of the medicinal herb were comparatively evaluated and differentiated by a heat map and a 3D score plot...
December 23, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28039815/differential-phenolic-production-in-leaves-of-vitis-vinifera-cv-alvarinho-affected-with-esca-disease
#10
Marta R M Lima, Mafalda L Felgueiras, Ana Cunha, Gisela Chicau, Federico Ferreres, Alberto C P Dias
Esca is a destructive disease of complex etiology affecting grapevines worldwide. A major constraint to the study and control of esca is that the disease is not diagnosed until external leaf and/or fruit symptoms are visible; however external symptoms usually appear several years after infection onset. We studied the phenolic content of V. vinifera cv. Alvarinho leaves using high performance liquid chromatography-diode array detection-mass spectrometry (HPLC-DAD-MS)/LC-MS. Leaves from affected cordons with and without visible symptoms (diseased and apparently healthy leaves, respectively) and leaves from asymptomatic cordons (healthy leaves) were analyzed...
December 24, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28035685/a-medicinal-herb-cassia-alata-attenuates-quorum-sensing-in-chromobacterium-violaceum-and-pseudomonas-aeruginosa
#11
P D Rekha, H S Vasavi, C Vipin, K Saptami, A B Arun
Quorum sensing (QS) has been shown to play a crucial role in the pathogenesis in many bacteria and attenuation of QS is one of the targets of antimicrobial therapy with particular interest in combating drug resistance. This study reports the QS inhibitory activity of metabolites from Cassia alata L. (Ca. alata), an important medicinal herb widely used in the treatment of microbial infections. For investigating the QS inhibition (QSI) potential of Ca. alata L., initially, metabolites of the leaves extracted using ethanol were tested against biosensor strain Chromobacterium violaceum CV026 and C...
December 30, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28035161/composition-bioactive-compounds-and-antioxidant-activity-of-common-indian-fruits-and-vegetables
#12
Jatinder Pal Singh, Amritpal Kaur, Khetan Shevkani, Narpinder Singh
The present work was undertaken to evaluate the chemical composition (proximate, minerals and dietary fibre), colour parameters, antioxidant activity and polyphenol profiles of different fruits (pomegranate, kinnow, mango, banana, jambolan, grapes and sapodilla) and vegetables (beetroot, brinjal, orange carrot, bitter gourd, mentha and spinach). The amount of insoluble dietary fibre was higher than soluble dietary fibre for all fruits and vegetables. Vegetables showed superior mineral composition (higher amounts of K, Ca and Fe) as compared to fruits...
November 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28033719/flavonol-glycosides-from-the-leaves-of-elaeagnus-pungens
#13
Ying-Ying Shang, Qin Qin, Meng-Shun Li, Hai-Yan Xu, Yue-Bin Ge
The leaves of Elaeagnus pungens were extracted and successively purified by a set chromatographic techniques. The structures of the obtained constituents were elucidated on the basis of spectroscopic methods including 1D/2D NMR and high resolution-MS. One new flavonoid glycosides, kaempferol 3-O-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 6)-[α-l-rhamnopyranosyl(1 → 2)]-β-d-galactopyranoside-7-O-β-d-glucopyranoside (1), along with five known compounds (2-6) were isolated and identified. The MTT assay in vitro showed that the isolated flavonol glycosides have no proliferating activity, suggesting no aggravating impact on the increased airway smooth muscle cells...
December 29, 2016: Natural Product Research
https://www.readbyqxmd.com/read/28029062/the-main-constituents-of-tulipa-systola-stapf-roots-and-flowers-their-antioxidant-activities
#14
Mohammed Farhad Ibrahim, Faiq Hama Saeed Hussain, Giuseppe Zanoni, Giovanni Vidari
People living on the mountains of the Kurdistan Region, Iraq make a large use of herbs in the local traditional medicine. Among them, Tulipa systola, which grows under and between rocks, is very popular as an anti-inflammatory remedy and pain-relief. The phytochemical study of an ethanolic extract obtained from flowers and roots of Tulip (T systola Stapf.) afforded three compounds, identified as (+)-1-O-E-feruloyl-3-O-E-p-coumaroylglycerol (1), (+)-6-tuliposide A (2), and (-)-kaempferol-3-O-rutinoside (3). The significant radical scavenging and antioxidant activity of the isolated compounds were evaluated on three tests, by determining the DPPH free radical scavenging activity, the total antioxidant activity and the hydrogen peroxide scavenging activity...
December 28, 2016: Natural Product Research
https://www.readbyqxmd.com/read/28025554/antioxidant-activities-and-chemical-constituents-of-flavonoids-from-the-flower-of-paeonia-ostii
#15
Huifang Zhang, Xiaofang Li, Ke Wu, Mengke Wang, Pu Liu, Xinsheng Wang, Ruixue Deng
Paeonia ostii is a traditional medicinal plant popularly used in China. This study intended to evaluate the antioxidant properties and the chemical components of the flavonoid-rich extracts from the flowers of P. ostii. The results showed that the flavonoid-rich extracts from the flowers of P. ostii had strong scavenging capacities on 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS), hydroxyls, superoxide anions, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent manner. Five flavonoids, dihydrokaempferol (1), apigenin-7-O-β-d-glucoside (2), apigenin-7-O-β-d-neohesperidoside (3), kaempferol-7-O-β-d-glucopyranoside (4), and kaempferol-3-O-β-d-glucopyranosyl-7-O-β-d-glucopyranoside (5), were isolated from the flavonoid-rich extracts of the flowers of P...
December 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27986590/phytosteroids-beyond-estrogens-regulators-of-reproductive-and-endocrine-function-in-natural-products
#16
REVIEW
Matthew Dean, Brian T Murphy, Joanna E Burdette
Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids - chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations...
December 13, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27984819/characterization-and-quantitation-of-the-polyphenolic-compounds-detected-in-methanol-extracts-of-pistacia-atlantica-desf-fruits-from-the-guelmim-region-of-morocco
#17
Farid Khallouki, Andrea Breuer, Elzemzoumi Merieme, Cornelia M Ulrich, Robert W Owen
High performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) was used for the identification of the major phenolic compounds in mature P. atlantica fruits from the Guelmim region (southeast of Morocco). In this study twenty seven polyphenolic compounds are identified and quantitated. To date, this is the most comprehensive report on the polyphenolic content of Pistacia fruits. The profiles comprise, three major polyphenolic classes, namely gallates (18.76g/kg; 63...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27982513/a-new-iridoid-dimer-and-other-constituents-from-the-traditional-kurdish-plant-pterocephalus-nestorianus-nab
#18
Fuad O Abdullah, Faiq H S Hussain, Marco Clericuzio, Alessio Porta, Giovanni Vidari
Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside (1), showing an unprecedented secologanol stereochemistry, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus, which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D and 2D NMR spectroscopic data. Kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl) β-D-glucopyranoside (7) showed a remarkable antiproliferative activity against several human tumor cell lines...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27979305/comparative-assessment-of-phytochemical-profiles-antioxidant-and-antiproliferative-activities-of-sea-buckthorn-hippopha%C3%A3-rhamnoides-l-berries
#19
Ruixue Guo, Xinbo Guo, Tong Li, Xiong Fu, Rui Hai Liu
Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27979208/prediction-of-chinese-green-tea-ranking-by-metabolite-profiling-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-q-tof-ms
#20
Jin Jing, Yuanzhi Shi, Qunfeng Zhang, Jie Wang, Jianyun Ruan
Metabolomics profiling provides comprehensive picture of the chemical composition in teas therefore may be used to assess tea quality objectively and reliably. In the present experiment, water and methanol extracts of green teas from China were analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) with the objectives to establish a model for quality prediction and to identify potential marker metabolites. The blindly evaluated sensory score of green teas was predicted with excellent power (R(2)=0...
April 15, 2017: Food Chemistry
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