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kaempferol

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https://www.readbyqxmd.com/read/29772774/selected-plant-metabolites-involved-in-oxidation-reduction-processes-during-bud-dormancy-and-ontogenetic-development-in-sweet-cherry-buds-prunus-avium-l
#1
Susanne Baldermann, Thomas Homann, Susanne Neugart, Frank-M Chmielewski, Klaus-Peter Götz, Kristin Gödeke, Gerd Huschek, Getrud E Morlock, Harshadrai M Rawel
Many biochemical processes are involved in regulating the consecutive transition of different phases of dormancy in sweet cherry buds. An evaluation based on a metabolic approach has, as yet, only been partly addressed. The aim of this work, therefore, was to determine which plant metabolites could serve as biomarkers for the different transitions in sweet cherry buds. The focus here was on those metabolites involved in oxidation-reduction processes during bud dormancy, as determined by targeted and untargeted mass spectrometry-based methods...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772356/assessment-of-toxicity-and-differential-antimicrobial-activity-of-methanol-extract-of-rhizome-of-simaba-ferruginea-a-st-hil-and-its-isolate-canthin-6-one
#2
Vanessa Fátima Gazoni, Sikiru Olaitan Balogun, Karuppusamy Arunacham, Darley Maria Oliveira, Valdir Cechinel Filho, Samara Rosolem Lima, Edson Moleta Colodel, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. AIM: This study aims to investigate the toxicity, antimicrobial activities of methanol extract of Simaba ferruginea (MESf) and canthin-6-one by using different experimental models...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29771951/antitumor-antioxidant-and-anti-inflammatory-activities-of-kaempferol-and-its-corresponding-glycosides-and-the-enzymatic-preparation-of-kaempferol
#3
Jingqiu Wang, Xianying Fang, Lin Ge, Fuliang Cao, Linguo Zhao, Zhenzhong Wang, Wei Xiao
Kaempferol (kae) and its glycosides are widely distributed in nature and show multiple bioactivities, yet few reports have compared them. In this paper, we report the antitumor, antioxidant and anti-inflammatory activity differences of kae, kae-7-O-glucoside (kae-7-O-glu), kae-3-O-rhamnoside (kae-3-O-rha) and kae-3-O-rutinoside (kae-3-O-rut). Kae showed the highest antiproliferation effect on the human hepatoma cell line HepG2, mouse colon cancer cell line CT26 and mouse melanoma cell line B16F1. Kae also significantly inhibited AKT phosphorylation and cleaved caspase-9, caspase-7, caspase-3 and PARP in HepG2 cells...
2018: PloS One
https://www.readbyqxmd.com/read/29758481/kaempferol-alleviates-palmitic-acid-induced-lipid-stores-endoplasmic-reticulum-stress-and-pancreatic-%C3%AE-cell-dysfunction-through-ampk-mtor-mediated-lipophagy
#4
Ritu Varshney, Rajat Varshney, Rutusmita Mishra, Sumeet Gupta, Debabrata Sircar, Partha Roy
Kaempferol, a natural flavonoid, has the beneficial effects of preserving pancreatic β-cell mass and function, but its action on β-cell lipid metabolism still remains elusive. Recently, autophagy has been reported to play a major role in lipid metabolism in various cell types, but its role in pancreatic β-cell's lipid metabolism is rarely reported. Here, we investigated the role of kaempferol-induced autophagy in inhibition of lipid stores, ER stress and β-cell dysfunction in palmitic acid-challenged RIN-5F cells and isolated pancreatic islets...
March 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29757247/enrichment-and-purification-of-total-ginkgo-flavonoid-o-glycosides-from-ginkgo-biloba-extract-with-macroporous-resin-and-evaluation-of-anti-inflammation-activities-in-vitro
#5
Lihu Zhang, Tingting Wu, Wei Xiao, Zhenzhong Wang, Gang Ding, Linguo Zhao
In the present study, the performance and separation characteristics of six macroporous resins for the enrichment and purification of total ginkgo flavonoid O -glycosides (TGFs) (quercetin (I), kaempferol (II), isorhamnetin (III)) from Ginkgo Biloba extracts (EGB) are evaluated. The adsorption and desorption properties of TGFs are studied on macroporous resins, including D101, D201, AB-8, HPD400, D301, and D311. Along with the results, AB-8 resin exhibits the best adsorption and desorption capacity for these three ginkgo flavonoid O -glycosides among the six resins...
May 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29753236/comparing-the-binding-interaction-between-%C3%AE-lactoglobulin-and-flavonoids-with-different-structure-by-multi-spectroscopy-analysis-and-molecular-docking
#6
Ti Li, Peng Hu, Taotao Dai, Panying Li, Xiaoqin Ye, Jun Chen, Chengmei Liu
Four kinds of flavonoids (apigenin, naringenin, kaempferol, genistein) were skillfully selected to investigate the interaction between flavonoids and β-lactoglobulin (β-LG) by multi-spectroscopy analysis and molecular docking. Hydrogenation on C2C3 double bond weakened the affinity of apigenin for β-LG and it's most obvious, followed by hydroxylation of C3 and position isomerism of phenyl ring B. The main interaction force for apigenin and naringenin binding to β-LG (van der Waals forces and hydrogen bonds) was different from that of genistein and kaempferol (hydrophobic interactions)...
May 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29752123/synthesis-and-characterization-of-kaempferol-based-ruthenium-ii-complex-a-facile-approach-for-superior-anticancer-application
#7
Prakash Thangavel, Buddolla Viswanath, Sanghyo Kim
In this study, we synthesized a novel metal flavonoid complex and investigated its effects on the non-small cell lung cancer cell lines, A549 and toxicity on the human dermal fibroblast cell lines, HDFa. 1 H, 13 C NMR, single crystal X-ray diffraction and elemental micro analysis (C,H,N,S/O) were used to characterize the synthesized kaempferol-based Ru (II) complex. Cell toxicity was studied using MTT assay and electric cell substrate impedance sensing (ECIS). It was evident from the MTT results that no significant cytotoxicity in HDFa cells occurs with the synthesized complex, but in case of A549 cells, significant cytotoxicity was observed even at low concentrations (10-20 μm)...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29751521/chromatogram-bioactivity-correlation-based-discovery-and-identification-of-three-bioactive-compounds-affecting-endothelial-function-in-ginkgo-biloba-extract
#8
Hong Liu, Li-Ping Tan, Xin Huang, Yi-Qiu Liao, Wei-Jian Zhang, Pei-Bo Li, Yong-Gang Wang, Wei Peng, Zhong Wu, Wei-Wei Su, Hong-Liang Yao
Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3- O -α-l-glucoside, 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29748497/profiling-of-phenolic-compounds-and-antioxidant-activity-of-12-cruciferous-vegetables
#9
Zhifeng Li, Hui Wen Lee, Xu Liang, Dong Liang, Qi Wang, Dejian Huang, Choon Nam Ong
The phenolic profiles of 12 cruciferous vegetables (pakchoi, choysum, Chinese cabbage, kailan, Brussels sprout, cabbage, cauliflower, broccoli, rocket salad, red cherry radish, daikon radish, and watercress) were studied with UHPLC-MS/MS. Antioxidant activity and total phenolic content (TPC) were also evaluated. A total of 74 phenolic compounds were identified, including 16 hydroxycinnamic acids and derivatives, and 58 flavonoids and derivatives. The main flavonoids identified were glycosylated quercetin, kaempferol and isorhamnetin, and the main hydroxycinnamic acids were ferulic, sinapic, caffeic and p -coumaric acids...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29747747/tiger-nut-and-walnut-extracts-modulate-extracellular-metabolism-of-atp-and-adenosine-through-the-nos-cgmp-pkg-signalling-pathway-in-kidney-slices
#10
Ayodeji A Olabiyi, Fabiano B Carvalho, Nathieli B Bottari, Vera M Morsch, Ademir F Morel, Ganiyu Oboh, Maria Rosa Schetinger
BACKGROUND: Tiger nut (Cyperus esculentus L.) and walnut (Tetracarpidium conophorum Müll. Arg.) have been reportedly used in the treatment of inflammatory diseases such as atherosclerosis, prevent heart attack and improve blood circulation, reduce serum cholesterol level as well as inhibit oxidation reactions. PURPOSE: This study investigated the effect of tiger nut and walnut hydro-alcoholic extracts on extracellular metabolism of ATP through the NOS/cGMP/PKG signaling pathway induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) in kidney slices...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29745345/protective-effect-of-kaempferol-on-the-transgenic-drosophila-model-of-alzheimer-s-disease
#11
Yasir Hasan Siddique, Tanveer Beg, Smita Jyoti, Falaq Naz, X Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad
BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human Aβ-42...
May 8, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29739490/kaempferol-suppresses-proliferation-and-induces-cell-cycle-arrest-apoptosis-and-dna-damage-in-breast-cancer-cells
#12
Li Zhu, Lijun Xue
Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus, we investigated how kaempferol suppresses the growth of BC cells. The cells were treated with kaempferol and the effects on multiple cancer-associated pathways were evaluated. The MTS assay was used to study the cell growth inhibition induced by kaempferol. The cell cycle (CC) was analyzed by flow cytometry...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29734760/kaempferol-induces-g2-m-cell-cycle-arrest-via-checkpoint-kinase-2-and-promotes-apoptosis-via-death-receptors-in-human-ovarian-carcinoma-a2780-cp70-cells
#13
Ying Gao, Junfeng Yin, Gary O Rankin, Yi Charlie Chen
Kaempferol is a widely distributed dietary flavonoid. Epidemiological studies have demonstrated kaempferol consumption lowers the risk of ovarian cancer. Our previous research proved that kaempferol suppresses human ovarian cancer cells by inhibiting tumor angiogenesis. However, the effects of kaempferol on the cell cycle and extrinsic apoptosis of ovarian cancer cells have not yet been studied. In the present study, we demonstrated that kaempferol induced G2/M cell cycle arrest via the Chk2/Cdc25C/Cdc2 pathway and Chk2/p21/Cdc2 pathway in human ovarian cancer A2780/CP70 cells...
May 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29734686/-buchanania-obovata-functionality-and-phytochemical-profiling-of-the-australian-native-green-plum
#14
Selina A Fyfe, Gabriele Netzel, Michael E Netzel, Yasmina Sultanbawa
The green plum is the fruit of Buchanania obovata Engl. and is an Australian Indigenous bush food. Very little study has been done on the green plum, so this is an initial screening study of the functional properties and phytochemical profile found in the flesh and seed. The flesh was shown to have antimicrobial properties effective against gram negative ( Escherichia coli 9001—NCTC) and gram positive ( Staphylococcus aureus 6571—NCTC) bacteria. Scanning electron microscopy analysis shows that the antimicrobial activity causes cell wall disintegration and cytoplasmic leakage in both bacteria...
May 4, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29729701/molecular-cloning-and-biotic-elicitation-response-of-phenylalanine-ammonia-lyase-gene-of-astragalus-chrysochlorus
#15
Neslihan Turgut Kara, Özgür Çakır, Burcu Arıkan, Şule Arı
Phenylalanine ammonia lyase (PAL) is the first enzyme of the phenylpropanoid pathway, and it is necessary to upregulate flavonoid biosynthesis in most of the plant species. In this study, we have cloned PAL gene from endemic Astragalus chrysochlorus which is a producer of phenolic nicotiflorin (kaempferol-3-O-rutinoside). The cDNA encoding PAL was cloned from A. chrysochlorus using RT-PCR (reverse transcription-polymerase chain reaction) with conserved primer pairs. Amino acid sequence alignments showed that AcPAL (2160 bp, Accession number: KM189182) has more than 95% amino acid identity with their homologues in other Astragalus species...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29725354/src-is-a-prime-target-inhibited-by-celtis-choseniana-methanol-extract-in-its-anti-inflammatory-action
#16
Han Gyung Kim, Subin Choi, Jongsung Lee, Yo Han Hong, Deok Jeong, Keejung Yoon, Deok Hyo Yoon, Gi-Ho Sung, Seungihm Lee, Suntaek Hong, Young-Su Yi, Jong-Hoon Kim, Jae Youl Cho
Celtis choseniana is the traditional plant used at Korea as a herbal medicine to ameliorate inflammatory responses. Although Celtis choseniana has been traditionally used as a herbal medicine at Korea, no systemic research has been conducted on its anti-inflammatory activity. Therefore, the present study explored an anti-inflammatory effect and its underlying molecular mechanism using Celtis choseniana methanol extract (Cc-ME) in macrophage-mediated inflammatory responses. In vitro anti-inflammatory activity of Cc-ME was evaluated using RAW264...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29720160/brazilian-propolis-ethanol-extract-and-its-component-kaempferol-induce-myeloid-derived-suppressor-cells-from-macrophages-of-mice-in-vivo-and-in-vitro
#17
Hiroshi Kitamura, Natsuko Saito, Junpei Fujimoto, Ken-Ichi Nakashima, Daisuke Fujikura
BACKGROUND: Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid derivatives, and it has been widely used in folk medicine owing to its anti-inflammatory, anti-viral, tumoricidal, and analgesic effects. Moreover, it is applied to prevent metabolic disorders, such as type 2 diabetes and arteriosclerosis. Previously, we demonstrated that propolis ethanol extract ameliorated type 2 diabetes in a mouse model through the resolution of adipose tissue inflammation...
May 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29719159/cuscuta-arvensis-beyr-dodder-in-vivo-hepatoprotective-effects-against-acetaminophen-induced-hepatotoxicity-in-rats
#18
Ufuk Koca-Caliskan, Ismet Yilmaz, Asli Taslidere, Funda N Yalcin, Ceylan Aka, Nazim Sekeroglu
Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as "dodder" in Europe, in the United States, and "tu si zi shu" in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C...
May 2, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29715320/deciphering-the-binding-behavior-of-flavonoids-to-the-cyclin-dependent-kinase-6-cyclin-d-complex
#19
Jingxiao Zhang, Lilei Zhang, Yangcheng Xu, Shanshan Jiang, Yueyue Shao
Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6. To understand the binding behavior of flavonoids that inhibit the active CDK6, molecular dynamics (MD) simulations were performed on six inhibitors, chrysin (M01), fisetin (M03), galangin (M04), genistein (M05), quercetin (M06) and kaempferol (M07), complexed with CDK6/cyclin D. For all six flavonoids, the 3'-OH and 4'-OH of B-ring were found to be favorable for hydrogen bond formation, but the 3-OH on the C-ring and 5-OH on the A-ring were unfavorable, which were confirmed by the MD simulation results of the test molecule, 3', 4', 7-trihydroxyflavone (M15)...
2018: PloS One
https://www.readbyqxmd.com/read/29713363/hypoglycaemic-and-antioxidant-effects-of-propolis-of-chihuahua-in-a-model-of-experimental-diabetes
#20
Nelly Rivera-Yañez, Mario Rodriguez-Canales, Oscar Nieto-Yañez, Manuel Jimenez-Estrada, Maximiliano Ibarra-Barajas, M M Canales-Martinez, M A Rodriguez-Monroy
Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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