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https://www.readbyqxmd.com/read/28928532/effect-of-interaction-of-epigallocatechin-gallate-and-flavonols-on-color-alteration-of-simulative-green-tea-infusion-after-thermal-treatment
#1
Qianying Dai, Yuanyuan He, Chit-Tang Ho, Jing Wang, Shujuan Wang, Yue Yang, Liping Gao, Tao Xia
Epigallocatechin gallate (EGCG) and flavonols are important phenolic compounds in green tea. These compounds are sensitive to thermal condition and their structural alteration results in making browning the green tea infusion. This study aimed to research the interaction between EGCG and flavonols during thermal infusion. EGCG and flavonols model solutions were prepared based on concentration in green tea infusion, and their colors appearance and attributes were analyzed in 10 h by thermal treatment. Results showed that kaempferol, quercetin, and myricetin accelerated the oxidation of EGCG and made the model solution browning...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28924370/kaempferol-inhibits-the-invasion-and-migration-of-renal-cancer-cells-through-the-downregulation-of-akt-and-fak-pathways
#2
Tung-Wei Hung, Pei-Ni Chen, Hsu-Chen Wu, Sheng-Wen Wu, Pao-Yu Tsai, Yih-Shou Hsieh, Horng-Rong Chang
Kaempferol, which is isolated from several natural plants, is a polyphenol belonging to the subgroup of flavonoids. Kaempferol exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this study, kaempferol can significantly inhibit the invasion and migration of 786-O renal cell carcinoma (RCC) without cytotoxicity. We examined the potential mechanisms underlying its anti-invasive activities on 786-O RCC cells. Western blot was performed, and the results showed that kaempferol attenuates the manifestation of metalloproteinase-2 (MMP-2) protein and activity...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28924162/insights-into-the-functionality-of-endophytic-actinobacteria-with-a-focus-on-their-biosynthetic-potential-and-secondary-metabolites-production
#3
Ajit Kumar Passari, Vineet Kumar Mishra, Garima Singh, Pratibha Singh, Brijesh Kumar, Vijai Kumar Gupta, Rupak Kumar Sharma, Ratul Saikia, Anthonia O' Donovan, Bhim Pratap Singh
Endophytic actinobacteria play an important role in growth promotion and development of host plant by producing enormous quantities of novel bioactive natural products. In the present investigation, 169 endophytic actinobacteria were isolated from endospheric tissues of Rhynchotoechum ellipticum. Based on their antimicrobial potential, 81 strains were identified by 16rRNA gene analysis, which were taxonomically grouped into 15 genera. All identified strains were screened for their plant growth promoting attributes and, for the presence of modular polyketide synthases (PKSI, PKSII and nonribosomal peptide synthetase (NRPS) gene clusters to correlate the biosynthetic genes with their functional properties...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911675/phenolic-constituents-of-pulicaria-undulata-l-c-a-mey-sub-sp-undulata-asteraceae-antioxidant-protective-effects-and-chemosystematic-significances
#4
Sameh R Hussein, Mona M Marzouk, Maha M Soltan, Emad K Ahmed, Mahmoud M Said, Ahmed R Hamed
One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), kaempferol 3-O-β-glucoside (3), quercetin (4), quercetin 3-O-β-glucoside (5), quercetin 3-O-β-galactoside (6), quercetin 3,7-di OCH3 (7), and caffeic acid (8). Their structures were established through chemical (acid hydrolysis) and spectral analysis (UV, NMR, and ESIM)...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910861/antioxidative-and-antiaging-activities-and-component-analysis-of-lespedeza-cuneata-g-don-extracts-fermented-with-lactobacillus-pentosus
#5
Joon Seob Seong, Song Hua Xuan, So Hyun Park, Keon Soo Lee, Young Min Park, Soo Nam Park
Lespedeza cuneata G. Don is a traditional herb that has been shown to associate with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells...
September 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28895216/metabolic-alterations-in-two-cirsium-species-identified-at-distinct-phenological-stages-using-uplc-qtof-ms
#6
Min-Sun Kim, Miso Nam, Geum-Sook Hwang
INTRODUCTION: Cirsium chanroenicum and C. setidens are commonly used both in traditional folk medicine and as a food source. The quality of different species of Cirsium at different harvest times is a function of their metabolite composition, which is determined by the phenological stage. OBJECTIVE: We sought to determine the differences in the metabolite composition of two species of Cirsium during different phenological stages using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight (QTOF) mass spectrometry (MS)...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28894456/effects-of-combined-low-glutathione-with-mild-oxidative-and-low-phosphorus-stress-on-the-metabolism-of-arabidopsis-thaliana
#7
Atsushi Fukushima, Mami Iwasa, Ryo Nakabayashi, Makoto Kobayashi, Tomoko Nishizawa, Yozo Okazaki, Kazuki Saito, Miyako Kusano
Plants possess highly sensitive mechanisms that monitor environmental stress levels for a dose-dependent fine-tuning of their growth and development. Differences in plant responses to severe and mild abiotic stresses have been recognized. Although many studies have revealed that glutathione can contribute to plant tolerance to various environmental stresses, little is known about the relationship between glutathione and mild abiotic stress, especially the effect of stress-induced altered glutathione levels on the metabolism...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28892660/phytotoxic-triterpene-saponins-from-bellis-longifolia-an-endemic-plant-of-crete
#8
Maria I Stavropoulou, Apostolis Angelis, Nektarios Aligiannis, Eleftherios Kalpoutzakis, Sofia Mitakou, Stephen O Duke, Nikolas Fokialakis
In a study of 62 plant species of the Cretan flora for their phytotoxic activity, plants were extracted successively with CH2Cl2, MeOH and H2O. Phytotoxicity evaluation of the 240 extracts was performed against Lactuca sativa L. and Agrostis stolonifera L.. The MeOH extract of Bellis longifolia was the most phytotoxic. Bioassay-guided fractionation revealed that a fraction consisting mainly of saponins was the most effective. Separation of the saponins was performed using initially a step-gradient Centrifugal Partition Chromatography (CPC)...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28886220/anti-inflammatory-effects-of-polyphenols-in-arthritis
#9
REVIEW
Francesca Oliviero, Anna Scanu, Yessica Zamudio-Cuevas, Leonardo Punzi, Paolo Spinella
Polyphenols have been extensively investigated with regard to their anti-oxidant, anti-inflammatory, and immunomodulant properties in many inflammatory chronic conditions. The aim of this review is to summarize how these compounds can modulate the inflammatory pathways which characterize the most prevalent arthropathies including osteoarthritis, rheumatoid arthritis and crystal-induced arthritis. Among polyphenols, epigallocatechin gallate, carnosol, hydroxytyrosol, curcumin, resveratrol, kaempferol and genistein have been the most widely investigated in arthritis...
September 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28884178/screening-of-potential-anti-adipogenic-effects-of-phenolic-compounds-showing-different-chemical-structure-in-3t3-l1-preadipocytes
#10
Andrea Mosqueda-Solís, Arrate Lasa, Saioa Gómez-Zorita, Itziar Eseberri, Catalina Picó, María P Portillo
This study was designed to analyze the anti-adipogenic effect of fifteen phenolic compounds from various chemical groups in 3T3-L1 pre-adipocytes. Cells were treated with 25 μM, 10 μM or 1 μM of apigenin, luteolin, catechin, epicatechin, epigallocatechin, genistein, daizein, naringenin, hesperidin, quercetin, kaempferol, resveratrol, vanillic acid, piceatannol and pterostilbene for 8 days. At 25 μM lipid accumulation was reduced by all the compounds, with the exception of catechin, epicatechin and epigallocatechin...
September 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28880226/quantitative-analysis-extraction-optimization-and-biological-evaluation-of-cudrania-tricuspidata-leaf-and-fruit-extracts
#11
Seung-Hui Song, Sung Hwan Ki, Dae-Hun Park, Hong-Seop Moon, Chang-Dai Lee, In-Soo Yoon, Seung-Sik Cho
Cudrania tricuspidata Bureau (Moraceae) shows numerous pharmacological effects and has been used in traditional herbal remedies for inflammation, gastritis, tumors, and liver diseases. However, no validated analytical method for the standardization and optimization of the biological properties of C. tricuspidata preparations has been reported. We developed and validated a reverse-phase high-performance liquid chromatography (HPLC) method for the separation and quantification of active markers. Ethanolic extracts of C...
September 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28876381/assessment-of-the-antiproliferative-and-antigenotoxic-activity-and-phytochemical-screening-of-aqueous-extracts-of-sambucus-australis-cham-schltdl-adoxaceae
#12
Marília Tedesco, Andrielle W Kuhn, Viviane Dal-Souto Frescura, Aline A Boligon, Margareth L Athayde, Solange B Tedesco, Antonio C F DA Silva
The purpose of this study was to evaluate the antiproliferative and antigenotoxic activity of Sambucus australis Cham. & Schltdl. aqueous extracts on the cell cycle of Allium cepa L. as well as determine the phenolic compounds in such extracts. S. australis inflorescences and leaves of two accessions were used for aqueous extract preparation at concentrations: 0.003 g/ml and 0.012 g/ml. A. cepa bulbs were rooted in distilled water and, subsequently, placed in treatments for 24 hours. Rootlets were collected and fixed in modified Carnoy's solution for 24 hours and kept...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28873690/nutritional-compound-analysis-and-morphological-characterization-of-spider-plant-cleome-gynandra-an-african-indigenous-leafy-vegetable
#13
Emmanuel O Omondi, Christof Engels, Godfrey Nambafu, Monika Schreiner, Susanne Neugart, Mary Abukutsa-Onyango, Traud Winkelmann
Spider plant is among the important indigenous African leafy vegetables having the potential to contribute to food and nutritional security in sub-Saharan Africa. The main objective of this study was to quantify the mineral concentration, to identify and quantify glucosinolates and flavonoids in spider plant and further to characterize spider plant entries using important morphological traits. Thirty spider plant entries from different African countries, comprising of farmers' cultivars, gene bank accessions and advanced lines were grown in a field experiment and harvested for leaves, stems, flowers and siliques at different developmental stages...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28870197/polarity-based-characterization-of-biologically-active-extracts-of-ajuga-bracteosa-wall-ex-benth-and-rp-hplc-analysis
#14
Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza, Ihsan-Ul Haq
BACKGROUND: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied. METHODS: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Specific polyphenols were quantified by RP-HPLC analysis. Preliminary cytotoxicity was tested using brine shrimp lethality assay while antiproliferative activity against THP-1 and Hep-G2 cell lines was determined by MTT and SRB protocols respectively...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28868116/bio-effectiveness-of-the-main-flavonoids-of-achillea-millefolium-in-the-pathophysiology-of-neurodegenerative-disorders-a-review
#15
REVIEW
Fatemeh Ayoobi, Ali Shamsizadeh, Iman Fatemi, Alireza Vakilian, Mohammad Allahtavakoli, Gholamhossein Hassanshahi, Amir Moghadam-Ahmadi
The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28867739/inhibitory-effects-of-juices-prepared-from-individual-vegetables-on-cyp3a4-activity-in-recombinant-cyp3a4-and-ls180-cells
#16
Masayuki Tsujimoto, Chie Agawa, Shinya Ueda, Takayoshi Yamane, Haruna Kitayama, Aya Terao, Tomoya Fukuda, Tetsuya Minegaki, Kohshi Nishiguchi
Human intestinal absorption and drug metabolism vary to a large extent among individuals. For example, CYP3A4 activity has large individual variation that cannot be attributed to only genetic differences. Various flavonoids in vegetables, such as kaempferol and quercetin, possess inhibitory effects, and some vegetable and fruit juices have also been found to inhibit CYP3A4 activity. Therefore, differences in daily intake of flavonoid-containing vegetables may induce individual variation in intestinal bioavailability...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28865123/kaempferol-increases-apoptosis-in-human-acute-promyelocytic-leukemia-cells-and-inhibits-multidrug-resistance-genes
#17
Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebkar
Acute promyelocytic leukemia (APL) is one of the most life-threatening hematological malignancies. Defects in the cell growth and apoptotic pathways are responsible for both disease pathogenesis and treatment resistance. Therefore, pro-apoptotic agents are potential candidates for APL treatment. Kaempferol is a flavonoid with antioxidant and anti-tumor properties. This study was designed to investigate the cytotoxic, pro-apoptotic and differentiation-inducing effects of kaempferol on HL-60 and NB4 leukemia cells...
September 2, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28861922/site-specific-accumulation-and-dynamic-change-of-flavonoids-in-apocyni-veneti-folium
#18
Cui-Hua Chen, Hu Xu, Xun-Hong Liu, Li-Si Zou, Mei Wang, Zi-Xiu Liu, Xing-Sheng Fu, Hui Zhao, Ying Yan
Site-specific accumulation of flavonoids in Apocyni Veneti Folium was determined by laser scanning confocal microscope (LSCM) and the localization of catechins also was observed via vanillin-HCl staining under the conventional optical microscope. The contents of five flavonoids in Apocyni Veneti Folium from different harvest times and growth parts were measured using HPLC method. LSCM observation showed that flavonoids are accumulated in cuticle of epidermal cells and vessel walls, especially in protoplasts and nucleolus of the collenchyma cells and the epidermal cells...
September 1, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28857481/fingerprint-profiles-of-flavonoid-compounds-from-different-psidium-guajava-leaves-and-their-antioxidant-activities
#19
Lu Wang, Yanan Wu, Qi Bei, Kan Shi, Zhenqiang Wu
Flavonoids are the main active components in Psidium guajava leaves and have many multi-physiological functions. In this study, the flavonoid compositions were identified in the Psidium guajava leaves samples using a high-performance liquid chromatography with time-of-flight electrospray ionization mass spectrometry method. A high-performance liquid chromatography fingerprint method, combined with chemometrics, was used to perform a quality assessment of the Psidium guajava leaves samples. The eight identified flavonoid compounds including rutin, isoquercitrin, quercetin-3-O-β-d-xylopyranoside, quercetin-3-O-α-l-arabinopyranoside, avicularin, quercitrin, quercetin, and kaempferol were used as the chemical markers...
August 31, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28854336/in-vitro-anti-inflammatory-activity-of-ilex-cornuta-extract-mediated-by-inhibition-of-extracellular-signal-regulated-kinase-phosphorylation
#20
Jisu Kim, Wonku Kang, Hyeyoung Min
Ilex cornuta, commonly known as Chinese holly, is an evergreen shrub from the family Aquifoliaceae, and it is widely distributed in Korea and China. In folk medicine, the leaves of I. cornuta are used for treatment of several disorders, including weakness of the waist and knees, arthrodynia, headache, acute conjunctivitis, toothache, urticaria, rheumatic arthralgia, and cardiovascular diseases. In this study, we investigated the anti-inflammatory effects of an I. cornuta leaf ethanol extract (ILE) and its underlying mechanisms of action...
August 30, 2017: Journal of Medicinal Food
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