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https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#1
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28427103/saffron-flower-extract-promotes-scratch-wound-closure-of-keratinocytes-and-enhances-vegf-production
#2
Sheela Verjee, Eliane Garo, Sarah Pelaez, Orlando Fertig, Matthias Hamburger, Veronika Butterweck
During saffron (Crocus sativus) spice production, large amounts of floral biowaste are generated. It was the aim of this study to develop a value-added product from saffron floral biowaste to be used as a natural cosmetic ingredient. HPLC-PDA-MS analysis of saffron flower extracts revealed the presence of flavonols with the highest amounts in the acetone extract. Kaempferol-3-O-sophoroside was identified as the main flavonoid in the acetone extract (saffron flower acetone extract). Saffron flower acetone extract and kaempferol-3-O-sophoroside were tested in HaCaT cells for potential effects on cell migration, proliferation, and for anti-inflammatory properties...
April 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28420096/a-network-based-pharmacology-study-of-the-herb-induced-liver-injury-potential-of-traditional-hepatoprotective-chinese-herbal-medicines
#3
Ming Hong, Sha Li, Hor Yue Tan, Fan Cheung, Ning Wang, Jihan Huang, Yibin Feng
Herbal medicines are widely used for treating liver diseases and generally regarded as safe due to their extensive use in Traditional Chinese Medicine practice for thousands of years. However, in recent years, there have been increased concerns regarding the long-term risk of Herb-Induced Liver Injury (HILI) in patients with liver dysfunction. Herein, two representative Chinese herbal medicines: one-Xiao-Chai-Hu-Tang (XCHT)-a composite formula, and the other-Radix Polygoni Multiflori (Heshouwu)-a single herb, were analyzed by network pharmacology study...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419331/an-apoplastic-%C3%AE-glucosidase-is-essential-for-the-degradation-of-flavonol-3-o-%C3%AE-glucoside-7-o-%C3%AE-rhamnosides-in-arabidopsis
#4
Jonathon Roepke, Harley O W Gordon, Kevin J A Neil, Satinder Gidda, Robert T Mullen, José A Freixas Coutin, Delaney Bray-Stone, Gale G Bozzo
Flavonol bisglycosides accumulate in plant vegetative tissues in response to abiotic stress, including simultaneous environmental perturbations (i.e., nitrogen deficiency and low temperature, NDLT), but disappear with recovery from NDLT. Previously, we determined that a recombinant Arabidopsis β-glucosidase (BGLU), BGLU15, hydrolyzes flavonol 3-O-β-glucoside-7-O-α-rhamnosides and flavonol 3-O-β-glucosides, forming flavonol 7-O-α-rhamnosides and flavonol aglycones, respectively. In this study, the transient expression of a BGLU15-Cherry fusion protein in onion epidermal cells demonstrated that BGLU15 was localized to the apoplast...
April 13, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28416882/chemical-composition-antiproliferative-and-antioxidant-activity-of-differently-processed-ganoderma-lucidum-ethanol-extracts
#5
Sonja Veljović, Mile Veljović, Ninoslav Nikićević, Saša Despotović, Siniša Radulović, Miomir Nikšić, Lana Filipović
The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, α- and β-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28411511/elevated-co2-and-salinity-are-responsible-for-phenolics-enrichment-in-two-differently-pigmented-lettuces
#6
Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci
Both salt stress and high CO2 level, besides influencing secondary metabolism, can affect oxidative status of plants mainly acting in an opposite way with salinity provoking oxidative stress and elevated CO2 alleviating it. The aim of the present work was to study the changes in the composition of phenolic acids and flavonoids as well as in the antioxidant activity in two differently pigmented lettuce cvs (green or red leaf) when submitted to salinity (200 mM NaCl) or elevated CO2 (700 ppm) or to their combination in order to evaluate how a future global change can affect lettuce quality...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28407916/protective-property-of-mulberry-digest-against-oxidative-stress-a-potential-approach-to-ameliorate-dietary-acrylamide-induced-cytotoxicity
#7
Linxia Zhang, Yang Xu, Yuting Li, Tao Bao, Vemana Gowd, Wei Chen
The aim of this study was investigating the protective effect of mulberry digest (MBD) on acrylamide-induced oxidative stress. Composition analysis of MBD revealed that it contained six major phenolic compounds (quercetin-3-O-rutinoside, quercetin hexoside, quercetin rhamnosylhexoside hexoside, kaempferol rhamnosylhexoside, cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside). After in vitro digestion, the contents of two anthocyanins were both decreased significantly, while the contents of four flavonoid glycosides were all increased...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407912/chemical-composition-of-edible-aerial-parts-of-meadow-bistort-persicaria-bistorta-l-samp
#8
Urszula Klimczak, Marta Woźniak, Michał Tomczyk, Sebastian Granica
Persicaria bistorta (syn. Polygonum bistorta) is a herbaceous plant native to Europe and Asia. The leaves, young shoots or aerial parts of bistort are one of the main ingredients in a savoury pudding common to parts of the North of England. The aim of the present study was to investigate the chemical composition of extracts from aerial parts of common bistort. The UHPLC method allowed the detection of thirty-five major and minor compounds in the analysed plant material. Major constituents were isolated and identified...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407891/antioxidants-and-%C3%AE-glucosidase-inhibitors-from-liucha-young-leaves-and-shoots-of-sibiraea-laevigata
#9
Jian-Qiang Zhao, Yan-Ming Wang, Yan-Long Yang, Ying Zeng, Li-Juan Mei, Yan-Ping Shi, Yan-Duo Tao
The young leaves and shoots of Sibiraea laevigata, known as "Liucha", are used as tea by Tibetans to improve digestion after meals. Long-term consumption of "Liucha" will cause weight loss. In present work, we reported on the isolation and NMR and chemical analysis-based elucidation of seven new sorbitol O-caffeic acid ester derivatives named sorbitol esters A-G (1-7) and eighteen known phenolic compounds from S. laevigata. All of the isolates were evaluated for their antioxidant and α-glucosidase inhibitory activities...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407532/rational-approach-to-solvent-system-selection-for-liquid-liquid-extraction-assisted-sample-pretreatment-in-counter-current-chromatography
#10
Jiajia Wang, Dongyu Gu, Miao Wang, Xinfeng Guo, Haoquan Li, Yue Dong, Hong Guo, Yi Wang, Mengqi Fan, Yi Yang
A rational liquid-liquid extraction approach was established to pre-treat samples for high-speed counter-current chromatography (HSCCC). n-Hexane-ethyl acetate-methanol-water (4:5:4:5, v/v) and (1:5:1:5, v/v) were selected as solvent systems for liquid-liquid extraction by systematically screening K of target compounds to remove low- and high-polarity impurities in the sample, respectively. After liquid-liquid extraction was performed, 1.4g of crude sample II was obtained from 18.5g of crude sample I which was extracted from the flowers of Robinia pseudoacacia L...
April 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28403640/a-kaempferol-triglycoside-from-tephrosia-preussii-taub-fabaceae
#11
Yves Martial Mba Nguekeu, Maurice Ducret Awouafack, Pierre Tane, Marius Roch Nguedia Lando, Takeshi Kodama, Hiroyuki Morita
A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitosterol (6). The structure of the new compound was characterised by analyses of NMR (1D and 2D) and MS data, and chemical conversion. Tephrokaempferoside (1) had weak antibacterial activity against Klebsiella pneumoniae with an MIC value of 150 μg/mL...
April 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28392458/anti-inflammatory-antimycobacterial-and-genotoxic-evaluation-of-doliocarpus-dentatus
#12
Raissa Borges Ishikawa, Maicon Matos Leitão, Roberto Mikio Kassuya, Luis Fernando Macorini, Flora Martinez Figueira Moreira, Claudia Andrea Lima Cardoso, Roberta Gomes Coelho, Arnildo Pott, Guilherme Martins Gelfuso, Julio Croda, Rodrigo Juliano Oliveira, Candida Aparecida Leite Kassuya
ETHNOPHARMACOLOGICAL RELEVANCE: Doliocarpus dentatus is a medicinal plant widely used in Mato Grosso do Sul State for removing the swelling pain caused by the inflammation process and for treating urine retention. AIM OF THE STUDY: The genotoxic aspects and the anti-inflammatory and antimycobacterial activity of the ethanolic extract obtained from the leaves of D. dentatus (EEDd) were investigated. MATERIALS AND METHODS: The EEDd was evaluated against Mycobacterium tuberculosis, and the compound composition was evaluated and identified by nuclear magnetic resonance (NMR)...
April 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28388787/antidiabetic-activities-of-an-lc-ms-fingerprinted-aqueous-extract-of-fagonia-cretica-l-in-preclinical-models
#13
Imran Nazir, Nisar Ur Rahman, Zunaira Alvi, M Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan
Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. Fagonia cretica is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study, the traditional medicine was prepared as a tea, and the profile of the main metabolites present in the traditional medicine was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glycoside, kaempferol-3(6'-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6″-malonylglucoside) in addition to two unidentified sulphonated saponins...
April 7, 2017: Planta Medica
https://www.readbyqxmd.com/read/28385048/a-new-alkaloid-and-flavonoids-isolated-from-solanum-cernuum-leaves-by-high-performance-countercurrent-chromatography
#14
Amaro Chaves Ramos, Rodrigo Rodrigues de Oliveira
Solanum cernuum is a medicinal plant widely distributed in south-east regions of Brazil and popularly used to treat several disorders. Despite their utilisation as a medicine, few studies on its chemical composition are reported. An efficient separation method for the ethyl acetate fraction was developed by high-performance countercurrent chromatography using n-butanol/chloroform/methanol/water (3:7:3:4, v/v/v/v) as the solvent system, affording five compounds (1-5) in one-step separation. A new cyclic guanidine alkaloid named cernidine (5) was obtained, besides four glycosylated flavonoids: afzelin (1), astragalin (2), kaempferol 3-O-α[apiofuranosyl-(1 → 2)]-α-rhamnopyranoside (3) and kaempferol 3-O-α[apiofuranosyl-(1→2)]-β-galactopyranoside (4)...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28362873/chitosan-propolis-nanoparticle-formulation-demonstrates-anti-bacterial-activity-against-enterococcus-faecalis-biofilms
#15
Teik Hwa Ong, Ebenezer Chitra, Srinivasan Ramamurthy, Rajinikanth Paruvathanahalli Siddalingam, Kah Hay Yuen, Stephen Periathamby Ambu, Fabian Davamani
Propolis obtained from bee hives is a natural substance with antimicrobial properties. It is limited by its insolubility in aqueous solutions; hence ethanol and ethyl acetate extracts of Malaysian propolis were prepared. Both the extracts displayed antimicrobial and anti-biofilm properties against Enterococcus faecalis, a common bacterium associated with hospital-acquired infections. High performance liquid chromatography (HPLC) analysis of propolis revealed the presence of flavonoids like kaempferol and pinocembrin...
2017: PloS One
https://www.readbyqxmd.com/read/28357634/bioactive-flavonoids-from-flos-sophorae
#16
Wenzhong Shi, Lili Liu, Jian Li, Lu Qu, Xu Pang, Haiyang Yu, Yi Zhang, Tao Wang
Three new flavonoid glycosides-soyaflavonosides A (1), B (2), and C (3)-together with 23 known ones were obtained from the 70% EtOH extract of Flos Sophorae (Sophora japonica, Leguminosae). Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14, 18, 20, 22, and 26 were isolated from the Sophora genus for the first time; 12, 19, 24, and 25 were obtained from the species firstly. Moreover, NMR data for compounds 18 and 26 are reported for the first time here. Meanwhile, compounds 4, 8-13, 15, 16, 19, 21, and 22 presented obvious inhibitory effects on TG accumulation in HepG2 cells...
March 29, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28348624/antioxidative-and-anti-inflammatory-activities-of-galloyl-derivatives-and-antidiabetic-activities-of-acer-ginnala
#17
Kwan Hee Park, Kyu Hyeong Yoon, Jun Yin, Thi Tam Le, Hye Sin Ahn, Seong Hye Yoon, Min Won Lee
Chromatographic isolation of the 80% MeOH extract of Acer ginnala (AG) yielded seven galloyl derivatives: gallic acid (1), ginnalin B (2), acertannin (3), maplexin D (4), maplexin E (5), quercetin-3-O-(2''-galloyl)-α-L-rhamnopyranoside (6), and kaempferol-3-O-(2''-galloyl)-α-L-rhamnopyranoside (7). This is the first study to report the isolation of compounds 4 and 5 from AG. Galloyl derivatives 3-7 exhibited potent radical scavenging activities, with 5 and 7 showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28347593/development-and-validation-of-a-fast-sfc-method-for-the-analysis-of-flavonoids-in-plant-extracts
#18
Yang Huang, Ying Feng, Guangyun Tang, Minyi Li, Tingting Zhang, Marianne Fillet, Jacques Crommen, Zhengjin Jiang
Flavonoids from plants always show a wide range of biological activities. In the present study, a rapid and highly efficient supercritical fluid chromatography (SFC) method was developed for the separation of 12 flavonoids. After careful optimization, the 12 flavonoids were baseline separated on a ZORBAX RX-SIL column using gradient elution. A 0.1% phosphoric acid solution in methanol was found to be the most suitable polar mobile phase component for the separation of flavonoids. From the viewpoint of retention and resolution, a backpressure of 200bar and a temperature of 40°C were shown to give the best results...
March 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28347185/chemical-composition-and-biological-activities-of-helicteres-vegae-and-heliopsis-sinaloensis
#19
Sandra Olivas-Quintero, Gabriela López-Angulo, Julio Montes-Avila, Sylvia Páz Díaz-Camacho, Rito Vega-Aviña, José Ángel López-Valenzuela, Nancy Yareli Salazar-Salas, Francisco Delgado-Vargas
CONTEXT: Helicteres vegae Cristóbal (Sterculiaceae) (Hv) and Heliopsis sinaloensis B.L. Turner (Asteraceae) (Hs) are endangered and poorly studied plant species; related plants have been used against chronic-degenerative and infectious diseases. Therefore, Hv and Hs could be sources of bioactive compounds against these illnesses. OBJECTIVE: To determine the chemical composition and biological activities (antioxidant, antimutagenic and antimicrobial) of Hv and Hs leaves (L) and stems (S)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28342004/modulatory-effects-of-terminalia-arjuna-against-domoic-acid-induced-toxicity-in-caco-2-cell-line
#20
E M Ramya, G Phani Kumar, T Anand, K R Anilakumar
Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress. The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis...
March 24, 2017: Cytotechnology
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