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https://www.readbyqxmd.com/read/28721659/antimicrobial-activity-of-selected-polyphenols-and-capsaicinoids-identified-in-pepper-capsicum-annuum-l-and-their-possible-mode-of-interaction
#1
Meriem Mokhtar, Giovanna Ginestra, Fatma Youcefi, Angela Filocamo, Carlo Bisignano, Ali Riazi
Antimicrobial activity of pepper polyphenols and capsaicinoids (Coumarin, caffeic acid, narangin, kaempferol, rutin, quercetin, capsaicin, and dihydrocapsaicin) against 13 pathogen bacteria and three beneficial strains was studied using the disk diffusion and microdilution methods. In general, phenolic compounds had the most important activity with the highest inhibition zones obtained with caffeic acid (3.5-20.5 mm), quercetin (4.75-3.5 mm), and kaempferol (7-14 mm). In the determination of the minimal inhibitory concentrations, the effects of both quercetin and kaempferol were more important than caffeic acid...
July 18, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28721446/rhamnolipids-enhance-in-vivo-oral-bioavailability-of-poorly-absorbed-molecules
#2
El-Sayed Khafagy, Mona F El-Azab, Mohamed E H ElSayed
PURPOSE: This report describes the effect of rhamnolipids (RLs) on the tight junctions (TJ) of the intestinal epithelium using the rat in-situ closed loop model. METHODS: We investigated the transport of 5 (6)-carboxyfluorescein (CF) and fluorescein isothiocyanate-labeled dextrans with average molecular weights of 4.4 and 10 kDa (FD-4 and FD-10) when co-administered with different concentrations of RLs. Lactate dehydrogenase (LDH) leakage assay and histopathological examination of treated intestinal loops were used to assess potential toxicity of RLs...
July 18, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28720971/determination-of-anthocyanins-and-non-anthocyanin-polyphenols-by-ultra-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry-uplc-esi-ms-in-jussara-euterpe-edulis-extracts
#3
Gláucia S Vieira, Anna S F Marques, Mariana T C Machado, Vanessa M Silva, Miriam D Hubinger
This work aimed to propose two analytical methods for the quantitative and qualitative analysis of major anthocyanins and non-anthocyanin phenolic compounds in jussara (Euterpe edulis) extracts, using ultra performance liquid chromatography-mass spectrometry. These methods were evaluated for selectivity, precision, linearity, detection and quantification limits. The complete separation of 5 anthocyanins and 22 non-anthocyanins polyphenols was achieved in 4.5 and 7 min, respectively. Limits of detection ranged from 0...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720959/fortification-of-the-whey-protein-isolate-antioxidant-and-antidiabetic-activity-with-fraction-rich-in-phenolic-compounds-obtained-from-stevia-rebaudiana-bert-bertoni-leaves
#4
Paula Gimenez Milani, Maysa Formigoni, Yago Carvalho Lima, Silvano Piovan, Giuliana Maria Ledesma Peixoto, Daiane Montoia Camparsi, Willian do Nascimento da Silva Rodrigues, Jordana Quaglia Pereira da Silva, Alexandre da Silva Avincola, Eduardo Jorge Pilau, Cecília Edna Mareze da Costa, Silvio Cláudio da Costa
A stevia fraction (ASF) free of steviol glycosides was extracted from Stevia rebaudiana leaves (Stevia UEM-13). ASF essentially constitutes phenolic compounds (52.42%), which were identified by liquid chromatography tandem mass spectrometry (LC-MS/MS) as caffeic acid, quercetin-3-o-glycoside, cyanidin-3-glucoside, kaempferol, quercetin, apigenin, rozmarinic acid, chlorogenic acid and dicaffeoylquinic acid. ASF was used as a multi-functional source of phenolic compounds to fortify the whey protein isolate (WPI) obtained by membrane separation...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28715245/enhanced-rutin-accumulation-in-tobacco-leaves-by-overexpressing-the-ntfls2-gene
#5
Junli Shi, Wenzheng Li, Yulong Gao, Bingwu Wang, Yong Li, Zhongbang Song
Rutin, one of the metabolites of the flavonoid pathway, shows great potential in industrial applications as a key component in pharmaceutical medicines and biological pesticides. Although the genetic manipulation of transcription factors (TFs) could increase rutin levels in plants, the accompanying accumulation of structurally similar chemicals complicates industrial rutin extraction. In this study, we demonstrated remarkably elevated rutin content (3.5-4.4-fold relative to controls) in transgenic tobacco plants by overexpressing NtFLS2...
July 17, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28714345/chemical-composition-and-antioxidant-activity-of-aerial-parts-of-ferula-longipes-coss-ex-bonnier-and-maury
#6
Aicha Bouratoua, Assia Khalfallah, Chawki Bensouici, Zahia Kabouche, Abdulmagid Alabdul Magid, Dominique Harakat, Laurence Voutquenne-Nazabadioko, Ahmed Kabouche
This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-[2-O-caffeoyl]-glucopyranoside (1), along with 10 known compounds kaempferol-3-O-α-L-rhamnopyranoside (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaempferol-3-O-ß-D-glucopyranoside-7-O-α-L-rhamnopyranoside (4), isorhamnetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (5), quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (6), isorhamnetin-3,7-di-O-β-D-glucopyranoside (7), apigenin (8), apigenin-7-O-ß-D-glucopyranoside (9), 3,5-dicaffeoylquinic acid (10), deltoin (11) were isolated from the aerial parts of Ferula longipes Coss...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28713417/foliar-phenolic-compounds-in-norway-spruce-with-varying-susceptibility-to-chrysomyxa-rhododendri-analyses-of-seasonal-and-infection-induced-accumulation-patterns
#7
Andrea Ganthaler, Wolfgang Stöggl, Ilse Kranner, Stefan Mayr
Secondary phenolic metabolites are involved in plant responses to various biotic stress factors, and are apparently important for the defense against fungal pathogens. In this study, we investigated their role in defense against the rust Chrysomyxa rhododendri in Norway spruce. The fungal pathogen undergoes a seasonal lifecycle with host shift; after overwintering in rhododendron shrubs, it attacks the sprouting current-year spruce needles and causes needle fall in autumn. Repeated infections lead to reduced timber yield and severe problems with rejuvenation in subalpine Norway spruce forests...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712963/anti-quorum-sensing-activity-of-pistacia-atlantica-against-pseudomonas-aeruginosa-pao1-and-identification-of-its-bioactive-compounds
#8
H Kordbacheh, F Eftekhar, S N Ebrahimi
Pseudomonas aeruginosa is a multidrug resistant opportunistic pathogen and an important cause of nosocomial infections. Quorum-sensing (QS) is a process in which bacterial cell-cell communication can regulates production of many virulence factors including pigment formation and the ability to form biofilm which is essential for establishment of chronic infections. We examined the inhibitory effect of Pistacia atlantica (Anacardiaceae) methanolic leaf extract and its bioactive components on biofilm formation and pigment production by P...
July 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28711657/kaempferol-impedes-il-32-induced-monocyte-macrophage-differentiation
#9
Sun-Young Nam, Hyun-Ja Jeong, Hyung-Min Kim
Kaempferol possesses a wide range of therapeutic properties, including antioxidant, anti-inflammatory, and anticancer properties. The present study sought to evaluate the effects and possible pharmacological mechanisms of kaempferol on interleukin (IL)-32-induced monocyte-macrophage differentiation. In this study, we performed flow cytometry assay, immunocytochemical staining, quantitative real-time PCR, enzyme-linked immuno sorbent assay, caspase-1 assay, and Western blotting to observe the effects and underlying mechanisms of kaempferol using the human monocyte cell line THP-1...
July 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28707708/identification-and-quantification-of-phenolic-compounds-in-edible-wild-leafy-vegetables-by-uhplc-orbitrap-ms
#10
Elisa Giambanelli, L Filippo D'Antuono, Roberto Romero-González, Antonia Garrido Frenich
BACKGROUND: A recent interest in edible wild leafy vegetables has been documented. Consumers often associate these species to health promotion. In this study several wild species of the Asteraceae family and Knautia integrifolia (Dipsacaceae) were locally documented for their use in traditional cuisine and sampled from the wild. RESULTS: Phenolic compounds were identified and quantified by ultra-high-performance liquid chromatography coupled to Orbitrap high resolution mass spectrometry...
July 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28707613/metabolic-profile-of-and-antimicrobial-activity-in-the-aerial-part-of-leonurus-turkestanicus-v-i-krecz-et-kuprian-from-kazakhstan
#11
Olga Sermukhamedova, Krzysztof Kamil Wojtanowski, Jarosław Widelski, Izabela Korona-Głowniak, Hosam O Elansary, Zuriyadda Sakipova, Anna Malm, Kazimierz Głowniak, Krystyna Skalicka-Woźniak
An HPLC quadrupole time-of-flight (Q-TOF) MS method was developed for the identification of secondary metabolites in Leonurus turkestanicus V.I. Krecz. et Kuprian. Ethanolic and chloroform extracts from the plant’s aerial parts were tested. A total of 16 compounds (iridoid glycosides, phenylpropanoids, flavonoids, and nitrogen-containing compounds, as well as diterpene acetate derivatives) were identified and tentatively characterized based on (or using) their retention times and UV and Q-TOF-MS data...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28701046/a-review-of-the-antioxidant-activity-of-celery-apium-graveolens-l
#12
Wesam Kooti, Nahid Daraei
Plants are an important source of natural active products that are different, based on mechanism and biological properties. Celery ( Apium graveolens L) is a plant from the apiaceae family and phenolic and antioxidant compounds of this plant have been studied by several scientists. The aim of this study was to review systematically the antioxidant activity of celery. Required articles were searched from databases such as Science Direct, PubMed, Scopus, and Springer. Keywords used in this study were Apium graveolens L, celery, antioxidant, free radical, leaf, and seed...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28698002/the-flavonol-enriched-cistus-albidus-chloroform-extract-possesses-in-vivo-anti-inflammatory-and-anti-nociceptive-activity
#13
Ouahiba Tahiri, Dina Atmani-Kilani, Susana Sanchez-Fidalgo, Marina Aparicio-Soto, Catalina Alarcón-de-la-Lastra, Enrique Barrajón-Catalán, Vicente Micol, Djebbar Atmani
ETHNOPHARMACOLOGICAL RELEVANCE: Cistus albidus L. (Cistaceae) has been traditionally used to treat various inflammatory diseases, but no systematic studies on the anti-inflammatory and anti-nociceptive actions of C. albidus and its putative mechanism have been reported. We aimed to explore the anti-inflammatory and anti-nociceptive effects of this plant and to characterize its polyphenolic composition by liquid chromatography coupled to mass spectrometry (MS). MATERIALS AND METHODS: A chloroform extract derived from C...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28694758/safety-assessment-and-antioxidant-activity-of-lantana-montevidensis-leaves-contribution-to-its-phytochemical-and-pharmacological-activity
#14
Luiz Marivando Barros, Antonia Eliene Duarte, Emily Pansera Waczuk, Katiane Roversi, Francisco Assis Bezerra da Cunha, Mirian Rolon, Cathia Coronel, Maria Celeste Vega Gomez, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Aline Augusti Boligon, Waseem Hassan, Diogo Onofre Souza, João Batista Teixeira da Rocha, Jean Paul Kamdem
Lantana camara, the widely studied species, and L. montevidensis, the less studied species of the genus Lantana are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of L. montevidensis and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of Lantana montevidensis in human leukocytes, as well as their possible interaction with human erythrocyte membranes in vitro...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28694749/variability-of-antioxidant-and-biological-activities-of-rhus-tripartitum-related-to-phenolic-compounds
#15
Hanène Ben Miled, Mariem Saada, Ines Jallali, Zaineb Ben Barka, Mounira Tlili, Hichem Alimi, Mohsen Sakly, Khémais Ben Rhouma, Manef Abderrabba, Hafedh Abdelmelek, Olfa Tebourbi, Riadh Ksouri
Rhus species are known in traditional medicine for their therapeutic virtue and their extracts showed numerous important properties including antimalarial, antimicrobial, antiviral, and hypoglycemic and anticonvulsant activities. Rhus tripartitum (Ucria) is a medicinal plant widely used in Tunisia folk medicine against chronic diarrhea and gastric ulcer. This study was designed to examine in vitro and ex vivo antioxidant, anti-inflammatory and anticancer activities of four extracts of Rhus tripartitum root cortex with increasing solvent polarity (hexane, dichloromethane, methanol and water)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28683180/multiconstituent-identification-in-root-branch-and-leaf-extracts-of-juglans-mandshurica-using-ultra-high-performance-liquid-chromatography-with-quadrupole-time-of-flight-mass-spectrometry
#16
Tian-Min Wang, Jing Liu, Tao Yi, Yan-Jun Zhai, Hui Zhang, Hu-Biao Chen, Shao-Qing Cai, Ting-Guo Kang, Zhong-Zhen Zhao
As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer. Different organs of this plant showed anti-tumor activity in clinic and laboratory. Comparative identification of constituents in different plant organs is essential for investigation of the relationship between chemical constituents and pharmacological activities. For this aim, the roots, branches, and leaves of J. mandshurica were extracted with 50% v/v methanol and then subjected to ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry analysis conducted under low and high energy...
July 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28680327/different-effects-of-feeding-pregnant-and-lactating-mice-rhodiola-kirilowii-aqueous-and-hydro-alcoholic-extracts-on-their-serum-angiogenic-activity-and-content-of-selected-polyphenols
#17
Robert Zdanowski, Ewa Skopińska-Różewska, Jacek Wilczak, Anna Borecka, Aneta Lewicka, Sławomir Lewicki
Angiogenesis plays an important role in many physiological processes, among them the formation of tissues and organs during embryogenesis. A lot of medicinal plants exhibit angiomodulatory properties. This creates the need for a thorough check of whether the plant extracts that we would like to give to pregnant women in order to increase their resistance to bacterial or viral infection will have negative effects on angiogenesis, and consequently on fetal development. This paper seeks to investigate the effect of serum of pregnant and nursing Balb/c mice that received aqueous (RKW) or hydro-alcoholic (RKW-A) R...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28677650/phytochemical-analysis-and-antimicrobial-activity-of-myrcia-tomentosa-aubl-dc-leaves
#18
Fabyola Amaral da Silva Sá, Joelma Abadia Marciano de Paula, Pierre Alexandre Dos Santos, Leandra de Almeida Ribeiro Oliveira, Gerlon de Almeida Ribeiro Oliveira, Luciano Morais Lião, José Realino de Paula, Maria do Rosário Rodrigues Silva
This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. The antibacterial and antifungal activities were assessed using the broth microdilution method...
July 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28667870/anti-radical-flavonol-glycosides-from-the-aerial-parts-of-cleome-chelidonii-l-f
#19
Phuc-Dam Nguyen, Charlotte Sayagh, Nicolas Borie, Catherine Lavaud
Eleven previously undescribed flavonoid glycosides, named cleomesides C-M, along with five known compounds, were isolated from the aerial parts of Cleome chelidonii L.f. (Cleomaceae). All flavonol glycosides were esterified derivatives of 3,7-O-diglycosides of quercetin or kaempferol. Their structures were elucidated by analysis of the 1D and 2D NMR spectra, HR-ESI-MS data, UV spectra, optical rotation and by comparison with literature data. The DPPH radical scavenging properties of the flavonoid glycosides were studied in order to appreciate the effect of the glycoside parts and of the ester groups on this activity compared with the quercetin and kaempferol aglycones...
June 28, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28663152/catalase-inhibition-an-anti-cancer-property-of-flavonoids-a-kinetic-and-structural-evaluation
#20
Debashis Majumder, Asmita Das, Chabita Saha
Flavonoids are dietary polyphenols that present abundantly in fruits and vegetables. Flavonoids have inhibitory effects on enzymes and catalase is one among them. Catalase is a common enzyme ubiquitously found in all living organisms exposed to oxygen. It catalyzes the decomposition of hydrogen peroxide to water and oxygen (2H2O2→2H2O+O2). Inhibition of pure and cellular catalase from K562 cells by flavonoids was similar and exhibited the following efficacy; Myrecetin>Quercetin>Kaempferol and Quercetin>Luteolin>Apigenin demonstrating structure activity relationship...
June 27, 2017: International Journal of Biological Macromolecules
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