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kaempferol

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https://www.readbyqxmd.com/read/27907185/antioxidant-antimicrobial-and-cytotoxic-properties-as-well-as-the-phenolic-content-of-the-extract-from-hancornia-speciosa-gomes
#1
Uilson P Santos, Jaqueline F Campos, Heron Fernandes V Torquato, Edgar Julian Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death...
2016: PloS One
https://www.readbyqxmd.com/read/27902959/kaempferol-a-phytoestrogen-suppressed-triclosan-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-mcf-7-breast-cancer-cells
#2
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
As a phytoestrogen, kaempferol is known to play a chemopreventive role inhibiting carcinogenesis and cancer progression. In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol...
November 22, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27896487/natural-compounds-as-occult-ototoxins-ginkgo-biloba-flavonoids-moderately-damage-lateral-line-hair-cells
#3
Sarah Neveux, Nicole K Smith, Anna Roche, Bruce E Blough, Wimal Pathmasiri, Allison B Coffin
Several drugs, including aminoglycosides and platinum-based chemotherapy agents, are well known for their ototoxic properties. However, FDA-approved drugs are not routinely tested for ototoxicity, so their potential to affect hearing often goes unrecognized. This issue is further compounded for natural products, where there is a lack of FDA oversight and the manufacturer is solely responsible for ensuring the safety of their products. Natural products such as herbal supplements are easily accessible and commonly used in the practice of traditional eastern and alternative medicine...
November 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27895660/ala-induced-flavonols-accumulation-in-guard-cells-is-involved-in-scavenging-h2o2-and-inhibiting-stomatal-closure-in-arabidopsis-cotyledons
#4
Yuyan An, Xinxin Feng, Longbo Liu, Lijun Xiong, Liangju Wang
5-aminolevulinic acid (ALA), a new plant growth regulator, can inhibit stomatal closure by reducing H2O2 accumulation in guard cells. Flavonols are a main kind of flavonoids and have been proposed as H2O2 scavengers in guard cells. 5-aminolevulinic acid can significantly improve flavonoids accumulation in plants. However, whether ALA increases flavonols content in guard cells and the role of flavonols in ALA-regulated stomatal movement remains unclear. In this study, we first demonstrated that ALA pretreatment inhibited ABA-induced stomatal closure by reducing H2O2 accumulation in guard cells of Arabidopsis seedlings...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27884717/activity-based-evaluation-of-a-traditional-ayurvedic-medicinal-plant-saraca-asoca-roxb-de-wilde-flowers-as-estrogenic-agents-using-ovariectomized-rat-model
#5
Gauri Swar, Sunita Shailajan, Sasikumar Menon
ETHNOPHARMACOLOGICAL RELEVANCE: Saraca asoca (Roxb.) de Wilde, Ashok, is a popular traditional plant used for gynecological disorders. In India, the juice of Ashok flowers is traditionally consumed as a tonic by women in case of uterine disorders. But despite the use, its estrogenic potency is not yet evaluated and thus lacks the scientific recognition and acclaim. AIM OF THE STUDY: This study is designed to investigate the estrogenic potential of standardized ethanolic extract of Saraca asoca flowers (SAF) using ovariectomized (OVX) female albino Wistar rat model...
November 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27867271/wound-healing-activity-and-chemical-standardization-of-eugenia-pruniformis-cambess
#6
Ricardo Diego Duarte Galhardo de Albuquerque, Jamila Alessandra Perini, Daniel Escorsim Machado, Thaís Angeli-Gamba, Ricardo Dos Santos Esteves, Marcelo Guerra Santos, Adriana Passos Oliveira, Leandro Rocha
BACKGROUND: Eugenia pruniformis is an endemic species from Brazil. Eugenia genus has flavonoids as one of the remarkable chemical classes which are related to the improvement of the healing process. AIMS: To evaluate of wound healing activity of E. pruniformis leaves and to identify and quantify its main flavonoids compounds. MATERIALS AND METHODS: Wound excision model in rats was used to verify the hydroethanolic and ethyl acetate extracts potential...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27866749/inter-population-and-inter-organ-distribution-of-the-main-polyphenolic-compounds-of-epilobium-angustifolium
#7
Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen
Rosebay willowherb (Epilobium angustifolium) contains large amounts of polyphenolic compounds, including tellimagrandin I-based oligomeric ellagitannins (ETs). The aim of this study was to assess the interpopulational and inter-organ variability of the polyphenol fingerprint of E. angustifolium. Seven ETs, 11 flavonol glycosides and neochlorogenic acid were quantified by UHPLC-DAD-ESI-QqQ-MS in the leaves, flowers and stem parts of plants from 10 populations. Total polyphenol content of leaves and flowers ranged from 150 to 200 mg/g dry wt, of which 90% was constituted by dimeric to heptameric ETs...
November 17, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27864869/anthoxanthin-polyphenols-attenuate-a%C3%AE-oligomer-induced-neuronal-responses-associated-with-alzheimer-s-disease
#8
Kayla M Pate, McCall Rogers, John Will Reed, Nicholas van der Munnik, Steven Zebulon Vance, Melissa A Moss
AIMS: Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. METHODS: Anthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action...
November 18, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27864542/involvement-of-three-putative-glucosyltransferases-from-the-ugt72-family-in-flavonol-glucoside-rhamnoside-biosynthesis-in-lotus-japonicus-seeds
#9
Qinggang Yin, Guoan Shen, Zhenzhan Chang, Yuhong Tang, Hongwen Gao, Yongzhen Pang
Flavonols are one of the largest groups of flavonoids that confer benefits for the health of plants and animals. Flavonol glycosides are the predominant flavonoids present in the model legume Lotus japonicus The molecular mechanisms underlying the biosynthesis of flavonol glycosides as yet remain unknown in L. japonicus. In the present study, we identified a total of 188 UDP-glycosyltransferases (UGTs) in L. japonicus by genome-wide searching. Notably, 12 UGTs from the UGT72 family were distributed widely among L...
November 17, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27862112/qualitative-and-quantitative-analysis-of-major-constituents-from-dazhu-hongjingtian-capsule-by-uplc-q-tof-ms-ms-combined-with-uplc-qqq-ms-ms
#10
Guang-Da Liu, Yi-Wu Zhao, Yan-Jing Li, Xue-Jing Wang, Hai-Hong Si, Wen-Zhe Huang, Zhen-Zhong Wang, Shi-Ping Ma, Wei Xiao
In this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major bioactive constituents in Dazhu Hongjingtian capsule by liquid chromatography tandem mass spectrometry (LC-MS). A total of 32 compounds were tentatively identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS/MS). Furthermore, twelve constituents, namely gallic acid, 3,4-dihydroxybenzoic acid, salidroside, p-coumaric acid-4-O-β-D-glucopyranoside, bergeninum, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, syringate, 6''-O-galloylsalidroside, rhodiosin, rhodionin and kaempferol-7-O-α-L-rhamnoside, were simultaneously quantified by the developed ultra-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QQQ-MS/MS) method in 9 min...
November 9, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27862041/screening-of-tyrosinase-inhibitors-by-capillary-electrophoresis-with-immobilized-enzyme-microreactor-and-molecular-docking
#11
Mengxia Cheng, Zilin Chen
A new method for screening tyrosinase inhibitors from traditional Chinese medicines (TCM) was successfully developed by capillary electrophoresis with reliable online immobilized enzyme microreactor (IMER). In addition, molecular docking study has been used for supporting inhabitation interaction between enzyme and inhibitors. The IMER of tyrosinase was constructed at the outlet of the capillary by using glutaraldehyde as cross-linker. The parameters including enzyme reaction, separation of the substrate and product, and the performance of immobilized tyrosinase were investigated systematically...
November 10, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27854350/cyclic-glucans-enhance-solubility-of-bioavailable-flavonoids
#12
REVIEW
Seyeon Park
Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water. As an important approach to enhance aqueous solubility, inclusion of hydrophobic guest molecules in hydrophilic hosts such as cyclic glucans has been used. This review summarizes applications of β-cyclodextrin, synthetic β-cyclodextrin derivatives, and newly synthesized derivatives of cyclosophoraoses as complexing agents to enhance the bioavailability of flavonoids such as baicalein, kaempferol, and naphthoflavones...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27853354/development-of-novel-her2-inhibitors-against-gastric-cancer-derived-from-flavonoid-source-of-syzygium-alternifolium-through-molecular-dynamics-and-pharmacophore-based-screening
#13
Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Vijaya Bhaskar Baki, Savita Devi, Duvvuru Gunasekar, Wudayagiri Rajendra
Continuous usage of synthetic chemotherapeutic drugs causes adverse effects, which prompted for the development of alternative therapeutics for gastric cancer from natural source. This study was carried out with a specific aim to screen gastroprotective compounds from the fruits of Syzygium alternifolium (Myrtaceae). Three flavonoids, namely, 1) 5-hydroxy-7,4'-dimethoxy-6,8-di-C-methylflavone, 2) kaempferol-3-O-β-d-glucopyranoside, and 3) kaempferol-3-O-α-l-rhamnopyranoside were isolated from the above medicinal plant by employing silica gel column chromatography and are characterized by NMR techniques...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27836511/deep-sequencing-of-the-transcriptome-reveals-distinct-flavonoid-metabolism-features-of-black-tartary-buckwheat-fagopyrum-tataricum-garetn
#14
REVIEW
Huipeng Yao, Chenglei Li, Haixia Zhao, Jianlan Zhao, Hui Chen, Tongliang Bu, Wang Anhu, Qi Wu
Black tartary buckwheat is recognized as 'black pearl' because of containg more rutin and other flavonoids as compared to yellow tartary buckwheat (traditional tartary buckwheat). Here, we show a genome-wide comparison of their transcriptomes by using an RNA-seq approach to elucidate the different molecular metabolism on the flowers from Black tartary buckwheat (HEIFENG No1) and yellow tartary buckwheat (XIQIAO No2). Over 48.4 million paired-end reads were assembled into 57,800 unigenes, of which about 57.9% (33, 472 unigenes) were annotated by BLAST searches in the NCBI non-redundant protein database...
November 8, 2016: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/27833438/the-inhibitory-effect-of-flavonoids-on-interleukin-8-release-by-human-gastric-adenocarcinoma-ags-cells-infected-with-cag-pai-helicobacter-pylori
#15
Mariusz A Skiba, Kornelia Szendzielorz, Bogdan Mazur, Wojciech Król
INTRODUCTION: It is well known that the presence of Helicobacter pylori in the stomach induces gastritis and causes an immune response. Exposure of gastric epithelial cell lines to this germ induces the secretion of interleukin-8 (IL-8), which is a potent PMN-activating chemotactic cytokine. Interleukin-8 is usually elevated in gastric biopsy samples of patients with H. pylori-associated gastritis and significantly increases in the supernatant of in vitro cultivated biopsy samples of gastric mucosa with active H...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27829862/assessment-of-antioxidant-activity-and-neuroprotective-capacity-on-pc12-cell-line-of-frankenia-thymifolia-and-related-phenolic-lc-ms-ms-identification
#16
Rim Ben Mansour, Wided Megdiche Ksouri, Stéphanie Cluzet, Stéphanie Krisa, Tristan Richard, Riadh Ksouri
This work aimed to investigate the richness of a Tunisian xerohalophyte Frankenia thymifolia aerial and root parts on phenolics and to evaluate the antioxidant and neuroprotective properties of this medicinal species. After fractionation using increasing and different solvent polarities, results displayed five fractions, where ethyl acetate (EtOAc) shoot and root fractions possess considerable total phenolic contents (221 and 308 mg of GAE/g of E, resp.) related to their important antioxidant activities such as ORAC (918 and 713 mg of TE/g of E), DPPH (282 and 821 mg of TE/g), and ABTS (778 and 1320 mg of TE/g) tests...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27826811/inducible-de-novo-biosynthesis-of-isoflavonoids-in-soybean-leaves-by-spodoptera-litura-derived-elicitors-tracer-techniques-aided-by-high-resolution-lcms
#17
Ryu Nakata, Yuki Kimura, Kenta Aoki, Naoko Yoshinaga, Masayoshi Teraishi, Yutaka Okumoto, Alisa Huffaker, Eric A Schmelz, Naoki Mori
Isoflavonoids are a characteristic family of natural products in legumes known to mediate a range of plant-biotic interactions. For example, in soybean (Glycine max: Fabaceae) multiple isoflavones are induced and accumulate in leaves following attack by Spodoptera litura (Lepidoptera: Noctuidae) larvae. To quantitatively examine patterns of activated de novo biosynthesis, soybean (Var. Enrei) leaves were treated with a combination of plant defense elicitors present in S. litura gut content extracts and L-α-[(13)C9, (15)N]phenylalanine as a traceable isoflavonoid precursor...
November 8, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27810677/effects-of-ambient-solar-uv-radiation-on-grapevine-leaf-physiology-and-berry-phenolic-composition-along-one-entire-season-under-mediterranean-field-conditions
#18
María-Ángeles Del-Castillo-Alonso, María P Diago, Rafael Tomás-Las-Heras, Laura Monforte, Gonzalo Soriano, Javier Martínez-Abaigar, Encarnación Núñez-Olivera
In the present study we assessed the effects of ambient solar UV exclusion on leaf physiology, and leaf and berry skin phenolic composition, of a major grapevine cultivar (Tempranillo) grown under typically Mediterranean field conditions over an entire season. In general, the effects of time were stronger than those of UV radiation. Ambient UV caused a little stressing effect (eustress) on leaf physiology, with decreasing net photosynthesis rates and stomatal conductances. However, it was not accompanied by alterations in Fv/Fm or photosynthetic pigments, and was partially counterbalanced by the UV-induced accumulation of protective flavonols...
October 22, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27810397/pharmacokinetics-of-dietary-kaempferol-and-its-metabolite-4-hydroxyphenylacetic-acid-in-rats
#19
Volha Zabela, Chethan Sampath, Mouhssin Oufir, Fahimeh Moradi-Afrapoli, Veronika Butterweck, Matthias Hamburger
SCOPE: Kaempferol is a major flavonoid in the human diet and in medicinal plants. The compound exerts anxiolytic activity when administered orally in mice, while no behavioural changes were observed upon intraperitoneal administration, or upon oral administration in gut sterilized animals. 4-Hydroxyphenylacetic acid (4-HPAA), which possesses anxiolytic effects when administered intraperitoneally, is a major intestinal metabolite of kaempferol. Pharmacokinetic properties of the compounds are currently not clear...
November 1, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27803764/the-chemical-profile-of-senna-velutina-leaves-and-their-antioxidant-and-cytotoxic-effects
#20
Jaqueline Ferreira Campos, David Tsuyoshi Hiramatsu de Castro, Marcio José Damião, Heron F Vieira Torquato, Edgar J Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells. The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract's inhibition of AAPH-induced lipid peroxidation in human erythrocytes...
2016: Oxidative Medicine and Cellular Longevity
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