Seyed Danial Alizadeh, Mohammad-Rasoul Jalalifar, Zahra Ghodsi, Mohsen Sadeghi-Naini, Hamid Malekzadeh, Golnoosh Rahimi, Kurosh Mojtabavi, Sina Shool, Zahra Eskandari, Rasoul Masoomi, Sahar Kiani, James Harrop, Vafa Rahimi-Movaghar
STUDY DESIGN: A Systematic Review OBJECTIVES: To determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal cord injury (SCI). METHODS: PRISMA 2020 guidelines were utilized, and search engines Medline, Web of Science, Scopus, and Embase until June 2023 were used. Studies that examined the effects of converting astrocytes into neuron-like cells with any vector in all animal models were included, while conversion from other cells except for spinal astrocytes, chemical mechanisms to provide SCI models, brain injury population, and conversion without in-vivo experience were excluded...
March 6, 2024: Spinal Cord