keyword
https://read.qxmd.com/read/38465221/ginsenoside-rg1-promotes-neurite-growth-of-retinal-ganglion-cells-through-camp-pka-creb-pathways
#21
JOURNAL ARTICLE
Ye-Ying Jiang, Rong-Yun Wei, Kai Tang, Zhen Wang, Ning-Hua Tan
BACKGROUND: Mechanisms of synaptic plasticity in retinal ganglion cells (RGCs) are complex and the current knowledge cannot explain. Growth and regeneration of dendrites together with synaptic formation are the most important parameters for evaluating the cellular protective effects of various molecules. The effect of ginsenoside Rg1 (Rg1) on the growth of retinal ganglion cell processes has been poorly understood. Therefore, we investigated the effect of ginsenoside Rg1 on the neurite growth of RGCs...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465219/the-pharmacological-role-of-ginsenoside-rg3-in-liver-diseases-a-review-on-molecular-mechanisms
#22
REVIEW
Wenhong Wang, Ke Li, Weihua Xiao
Liver diseases are a significant global health burden and are among the most common diseases. Ginssennoside Rg3 (Rg3), which is one of the most abundant ginsenosides, has been found to have significant preventive and therapeutic effects against various types of diseases with minimal side effects. Numerous studies have demonstrated the significant preventive and therapeutic effects of Rg3 on various liver diseases such as viral hepatitis, acute liver injury, nonalcoholic liver diseases (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC)...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465218/pharmacological-potential-of-ginseng-and-ginsenosides-in-nonalcoholic-fatty-liver-disease-and-nonalcoholic-steatohepatitis
#23
REVIEW
Young-Su Yi
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic fat accumulation, while nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD characterized by hepatic inflammation, fibrosis, and liver injury, resulting in liver cirrhosis and hepatocellular carcinoma (HCC). Given the evidence that ginseng and its major bioactive components, ginsenosides, have potent anti-adipogenic, anti-inflammatory, anti-oxidative, and anti-fibrogenic effects, the pharmacological effect of ginseng and ginsenosides on NAFLD and NASH is noteworthy...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465216/ginseng-root-derived-exosome-like-nanoparticles-protect-skin-from-uv-irradiation-and-oxidative-stress-by-suppressing-activator-protein-1-signaling-and-limiting-the-generation-of-reactive-oxygen-species
#24
JOURNAL ARTICLE
Wooram Choi, Jeong Hun Cho, Sang Hee Park, Dong Seon Kim, Hwa Pyoung Lee, Donghyun Kim, Hyun Soo Kim, Ji Hye Kim, Jae Youl Cho
BACKGROUND: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. METHODS: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 109 particles/mL), and followed by UVB irradiation or H2 O2 exposure...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465215/reciprocal-regulation-of-sirt1-and-ampk-by-ginsenoside-compound-k-impedes-the-conversion-from-plasma-cells-to-mitigate-for-podocyte-injury-in-mrl-lpr-mice-in-a-b-cell-specific-manner
#25
JOURNAL ARTICLE
Ziyu Song, Meng Jin, Shenglong Wang, Yanzuo Wu, Qi Huang, Wangda Xu, Yongsheng Fan, Fengyuan Tian
BACKGROUND: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. METHODS: Female MRL/ lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465214/ginseng-and-ginsenosides-on-cardiovascular-and-pulmonary-diseases-pharmacological-potentials-for-the-coronavirus-covid-19
#26
REVIEW
Ajay Vijayakumar, Jong-Hoon Kim
Since its outbreak in late 2019, the Coronavirus disease 2019 (COVID-19) pandemic has profoundly caused global morbidity and deaths. The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has major complications in cardiovascular and pulmonary system. The increased rate of mortality is due to delayed detection of certain biomarkers that are crucial in the development of disease. Furthermore, certain proteins and enzymes in cellular signaling pathways play an important role in replication of SARS-CoV-2...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465212/sustainable-production-of-natural-products-using-synthetic-biology-ginsenosides
#27
REVIEW
So-Hee Son, Jin Kang, YuJin Shin, ChaeYoung Lee, Bong Hyun Sung, Ju Young Lee, Wonsik Lee
Synthetic biology approaches offer potential for large-scale and sustainable production of natural products with bioactive potency, including ginsenosides, providing a means to produce novel compounds with enhanced therapeutic properties. Ginseng, known for its non-toxic and potent qualities in traditional medicine, has been used for various medical needs. Ginseng has shown promise for its antioxidant and neuroprotective properties, and it has been used as a potential agent to boost immunity against various infections when used together with other drugs and vaccines...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38464791/ginsenoside-rk3-modulates-gut-microbiota-and-regulates-immune-response-of-group-3-innate-lymphoid-cells-to-against-colorectal-tumorigenesis
#28
JOURNAL ARTICLE
Xue Bai, Rongzhan Fu, Yannan Liu, Jianjun Deng, Qiang Fei, Zhiguang Duan, Chenhui Zhu, Daidi Fan
The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer (CRC). However, the effect of ginsenoside Rk3 (Rk3) on CRC and gut microbiota remains unclear. Therefore, the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune regulation. Our results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors, repairs intestinal barrier damage, and regulates the gut microbiota imbalance caused by CRC, including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis , and clearance of pathogenic Desulfovibrio ...
February 2024: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/38461953/ginsenoside-rk1-induces-autophagy-dependent-apoptosis-in-hepatocellular-carcinoma-by-ampk-mtor-signaling-pathway
#29
JOURNAL ARTICLE
Huanyan Wu, Linlin Qu, Xue Bai, Chenhui Zhu, Yuan Liu, Zhiguang Duan, Hongyan Liu, Rongzhan Fu, Daidi Fan
Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Recent studies have shown that suppression of autophagy plays an important role in the development of HCC. Ginsenoside Rk1 is a protopanaxadiol saponin isolated from ginseng and has a significant anti-tumor effect, but its role and mechanism in HCC are still unclear. In this study, a mouse liver cancer model induced by diethylnitrosamine and carbon tetrachloride (DEN + CCl4 ) was employed to investigate the inhibitory effect of Rk1 on HCC...
March 8, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38455405/ginsenoside-rg3-decreases-breast-cancer-stem-like-phenotypes-through-impairing-myc-mrna-stability
#30
JOURNAL ARTICLE
Jin-Yue Ning, Zi-Han Zhang, Jia Zhang, Yong-Min Liu, Guan-Chu Li, A-Man Wang, Ying Li, Xiu Shan, Ju-Hong Wang, Xu Zhang, Yi Zhao
Breast cancer stem cells (BCSCs) are responsible for breast cancer metastasis, recurrence and treatment resistance, all of which make BCSCs potential drivers of breast cancer aggression. Ginsenoside Rg3, a traditional Chinese herbal medicine, was reported to have multiple antitumor functions. Here, we revealed a novel effect of Rg3 on BCSCs. Rg3 inhibits breast cancer cell viability in a dose- and time-dependent manner. Importantly, Rg3 suppressed mammosphere formation, reduced the expression of stemness-related transcription factors, including c-Myc, Oct4, Sox2 and Lin28, and diminished ALDH(+) populations...
2024: American Journal of Cancer Research
https://read.qxmd.com/read/38455159/ginseng-in-white-and-red-processed-forms-ginsenosides-and-cardiac-side-effects
#31
JOURNAL ARTICLE
Jiexin Zhou, Jiarui Zhang, Pu Jing, Yu Lan, Xiaonian Cao, Huafang Feng, Xiaogang Liu, Qingqing Liu
Ginseng ( Panax ginseng Meyer) has long been consumed as a medicinal or functional food in East Asia. It is available as dried white ginseng (WG) and steamed red ginseng (RG), which might differ in ginsenoside profiles. We compared ginsenoside types of RG and WG using UPLC-MS/MS and evaluated how they biologically affected heart of healthy rats by recording electrocardiography, measuring biochemical indicators, analyzing cardiac tissue slides, and Ca2+ signaling pathways. About 25 and 29 ginsenosides were detected in WG and RG, respectively, and the total ginsenoside content of RG contained was nearly 1...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38449105/progress-in-identification-of-udp-glycosyltransferases-for-ginsenoside-biosynthesis
#32
REVIEW
Xiaoxuan Yuan, Ruiqiong Li, Weishen He, Wei Xu, Wen Xu, Guohong Yan, Shaohua Xu, Lixia Chen, Yaqian Feng, Hua Li
Ginsenosides, the primary pharmacologically active constituents of the Panax genus, have demonstrated a variety of medicinal properties, including anticardiovascular disease, cytotoxic, antiaging, and antidiabetes effects. However, the low concentration of ginsenosides in plants and the challenges associated with their extraction impede the advancement and application of ginsenosides. Heterologous biosynthesis represents a promising strategy for the targeted production of these natural active compounds. As representative triterpenoids, the biosynthetic pathway of the aglycone skeletons of ginsenosides has been successfully decoded...
March 6, 2024: Journal of Natural Products
https://read.qxmd.com/read/38448665/reprogramming-of-astrocytes-to-neuronal-like-cells-in-spinal-cord-injury-a-systematic-review
#33
REVIEW
Seyed Danial Alizadeh, Mohammad-Rasoul Jalalifar, Zahra Ghodsi, Mohsen Sadeghi-Naini, Hamid Malekzadeh, Golnoosh Rahimi, Kurosh Mojtabavi, Sina Shool, Zahra Eskandari, Rasoul Masoomi, Sahar Kiani, James Harrop, Vafa Rahimi-Movaghar
STUDY DESIGN: A Systematic Review OBJECTIVES: To determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal cord injury (SCI). METHODS: PRISMA 2020 guidelines were utilized, and search engines Medline, Web of Science, Scopus, and Embase until June 2023 were used. Studies that examined the effects of converting astrocytes into neuron-like cells with any vector in all animal models were included, while conversion from other cells except for spinal astrocytes, chemical mechanisms to provide SCI models, brain injury population, and conversion without in-vivo experience were excluded...
March 6, 2024: Spinal Cord
https://read.qxmd.com/read/38445528/changes-in-chemical-components-and-hepatoprotective-effect-of-red-panax-notoginseng-processed-by-aspartic-acid-impregnation-treatment
#34
JOURNAL ARTICLE
Ying Cui, Jianfa Wu, Danli Zhang, Dan Li, Jing Zhang, Wei Li, Chongzhi Wang, Chunsu Yuan, Zhi Liu
BACKGROUND: Red Panax notoginseng (RPN) is one of the major processed products of Panax notoginseng (PN), with more effective biological activities. However, the traditional processing method of RPN has some disadvantages such as low conversion rate of ginsenosides and long processing time. RESULTS: In this work, we developed a green, safe and efficient approach for RPN processing by aspartic acid impregnation pretreatment. Our results showed that the optimized temperature, steaming time, and concentration of aspartic acid were 120°C, 1 h and 3%, respectively...
March 6, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38443173/-ginsenoside-f1-inhibits-cholesterol-overload-in-oxidative-damaged-cells-through-srebp2-hmgcr-pathway
#35
JOURNAL ARTICLE
Di Liu, Zhe Zhang, Tong Peng, Zixiang Yu, Jie Sun, Fanli Kong, Xianmin Feng
OBJECTIVE: To investigate the inhibitory mechanisms of ginsenoside F1 on hydrogen peroxide induced cholesterol metabolism disorder and oxidative stress in HepG2 cells. METHODS: 1, 1-diphenyl-2-picrylhydrazyl(DPPH) and oxygen radical absorbance capacity(ORAC) tests were used to detect the scavenging effect of ginsenoside F1 on nitrogen and oxygen free radicals. HepG2 cells were treated with 400 μmol/L hydrogen peroxide and pretreated with 10, 20 and 40 μmol/L ginsenoside F1...
January 2024: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://read.qxmd.com/read/38442431/intranasal-delivery-of-herbal-medicine-for-disease-treatment-a-systematic-review
#36
REVIEW
Khoa Nguyen Tran, Ji-Hye Kwon, Min-Kyung Kim, Nhi Phuc Khanh Nguyen, In-Jun Yang
BACKGROUND: Intranasal administration has been adopted in traditional medicine to facilitate access to the bloodstream and central nervous system (CNS). In modern medicine, nasal drug delivery systems are valuable for disease treatment because of their noninvasiveness, good absorption, and fast-acting effects. OBJECTIVE: This study aimed to systematically organize preclinical and clinical studies on intranasal herbal medicines to highlight their potential in drug development...
February 28, 2024: Phytomedicine
https://read.qxmd.com/read/38441023/ginsenoside-rg3-a-review-of-its-anticancer-mechanisms-and-potential-therapeutic-applications
#37
JOURNAL ARTICLE
Lei Wu, Lin Bai, Wenshu Dai, Yaping Wu, Pengjun Xi, Lily Zheng, Jie Zhang
BACKGROUND: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as a complementary therapy for cancer. A promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors and has proven to be effective in suppressing cancer. OBJECTIVE: This work covers various aspects of the role of ginsenoside Rg3 in cancer treatment, including its biological functions, key pathways, epigenetics, and potential for combination therapies, all of which have been extensively researched and elucidated...
March 4, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38441012/integrated-serum-pharmacochemistry-and-network-pharmacological-analysis-used-to-explore-possible-anti-aging-mechanisms-of-the-ginsenosides
#38
JOURNAL ARTICLE
Jing Li, Ruigang Li, Qing Yang, Xiaoran Liu, Xiaobo Qu, Na Li
BACKGROUND: Although constitutive ginsenosides are credited with ginseng's remarkable anti-aging efficacy, the mechanism of action and bioactive components of ginsenosides are unclear. OBJECTIVE: The goal of the study was to examine the effect of ginsenosides on D-galactose (Dgal)- induced aging in rats and to figure out the underlying molecular mechanism using serum pharmacochemistry and network pharmacology. METHODS: Using behavioral, biochemical indexes, and histological analysis, ginsenosides were evaluated for their anti-aging effects in rats induced by D-gal, and effective ingredients absorbed in the blood were examined by ultra-performance liquid chromatography quadrupole time of flight coupled with mass spectrometry (UPLC-Q/TOF-MS) before being subjected to network pharmacology analysis...
March 4, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38440685/ginsenosides-rh1-rg2-and-rg3-ameliorate-dexamethasone-induced-muscle-atrophy-in-c2c12-myotubes
#39
JOURNAL ARTICLE
Xiao Men, Xionggao Han, Se-Jeong Lee, Geon Oh, Ji-Hyun Im, Kwi Sik Bae, Geum-Su Seong, Im-Joung La, Do-Sang Lee, Sun-Il Choi, Ok-Hwan Lee
High doses or prolonged use of the exogenous synthetic glucocorticoid dexamethasone (Dex) can lead to muscle atrophy. In this study, the anti-atrophic effects of ginsenosides Rh1, Rg2, and Rg3 on Dex-induced C2C12 myotube atrophy were assessed by XTT, myotube diameter, fusion index, and western blot analysis. The XTT assay results showed that treatment with Rh1, Rg2, and Rg3 enhanced cell viability in Dex-injured C2C12 myotubes. Compared with the control group, the myotube diameter and fusion index were both reduced in Dex-treated cells, but treatment with Rh1, Rg2, and Rg3 increased these parameters...
April 2024: Food Science and Biotechnology
https://read.qxmd.com/read/38439883/creating-a-new-yellow-and-blue-combination-transparent-film-for-panax-ginseng-c-a-meyer-growth-based-on-orthogonal-designs
#40
JOURNAL ARTICLE
Zhenghai Zhang, Huixia Lei, Peihe Zheng, Yayu Zhang, Hai Sun, Cai Shao, Jingjing Zhao
Panax ginseng C.A. Meyer originates from old-growth forest environments, where the light intensity and spectrum reaching the forest bed are influenced by the canopy and humidity. In farmlands, suitable light intensity for cultivation is achieved by controlling the light transmission rate using shading nets, while light quality is regulated by a cover of yellow or blue transparent film. Such films have a light quality distinct from that produced by old-growth forests. Herein, a large composite film was developed by alternating small pieces of yellow and blue transparent film...
March 15, 2024: Heliyon
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