keyword
https://read.qxmd.com/read/38493413/biotransformation-approach-to-produce-rare-ginsenosides-f1-compound-mc1-and-rd2-from-major-ginsenosides
#1
JOURNAL ARTICLE
Mengxue Diao, Yanchi Chen, Lijun Meng, Jianxiu Li, Nengzhong Xie
The stems and leaves of Panax notoginseng contain high saponins, but they are often discarded as agricultural waste. In this study, the predominant ginsenosides Rg1, Rc, and Rb2, presented in the stems and leaves of ginseng plants, were biotransformed into value-added rare ginsenosides F1, compound Mc1 (C-Mc1), and Rd2, respectively. A fungal strain YMS6 (Penicillium sp.) was screened from the soil as a biocatalyst with high selectivity for the deglycosylation of major ginsenosides. Under the optimal fermentation conditions, the yields of F1, C-Mc1, and Rd2 were 97...
March 17, 2024: Archives of Microbiology
https://read.qxmd.com/read/38492794/mechanism-interpretation-of-guhan-yangshengjing-for-protection-against-alzheimer-s-disease-by-network-pharmacology-and-molecular-docking
#2
JOURNAL ARTICLE
Suet Cheung, Yuan Zhong, Lei Wu, Xiaomeng Jia, Meng-Qi He, Yongjian Ai, Qisen Jiao, Qionglin Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's disease (AD) based on the ancient Chinese medical classics excavated from Mawangdui Han Tomb. Comprising a combination of eleven traditional Chinese herbs, the precise protective mechanism through which GHYSJ acts on AD progression remains unclear and has significant implications for the development of new drugs to treat AD. AIM OF THE STUDY: To investigate the mechanism of GHYSJ in the treatment of AD through network pharmacology and validate the results through in vitro experiments...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38490314/sirtuin-1-in-osteoarthritis-perspectives-on-regulating-glucose-metabolism
#3
REVIEW
Zhihao Liao, Xuepei Cai, Yifan Zheng, Jiayu Lin, Xia Yang, Weiyin Lin, Ying Zhang, Xin He, Chufeng Liu
Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close association exists between glucose metabolism dysregulation and OA pathogenesis. Owing to the unique environment of low oxygen and glucose concentrations, chondrocytes rely heavily on their glycolytic capacity, exhibiting distinct spatiotemporal differences. However, under pathological stimulation, chondrocytes undergo excessive glycolytic activity while mitochondrial respiration and other branches of glucose metabolism are compromised...
March 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38488514/ginsenoside-rk3-regulates-tryptophan-metabolism-along-the-brain-gut-axis-by-targeting-tryptophan-hydroxylase-and-remodeling-the-intestinal-microenvironment-to-alleviate-depressive-like-behavior-in-mice
#4
JOURNAL ARTICLE
Jingjing Shao, Linlin Qu, Yao Liu, Jingjing Zhang, Yannan Liu, Jianjun Deng, Xiaoxuan Ma, Daidi Fan
Depression is a neuropsychiatric disease that significantly impacts the physical and mental health of >300 million people worldwide and places a major burden on society. Ginsenosides are the main active ingredient in ginseng and have been proven to have various pharmacological effects on the nervous system. Herein, we investigated the antidepressant effect of ginsenoside Rk3 and its underlying mechanism in a murine model of depression. Rk3 significantly improved depression-like behavior in mice, ameliorated the disturbance of the hypothalamus-pituitary-adrenal axis, and alleviated neuronal damage in the hippocampus and prefrontal cortex of mice...
March 15, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38485818/ginsenoside-rg1-relieves-rat-intervertebral-disc-degeneration-and-inhibits-il-1%C3%AE-induced-nucleus-pulposus-cell-apoptosis-and-inflammation-via-nf-%C3%AE%C2%BAb-signaling-pathway
#5
JOURNAL ARTICLE
Lei Yu, Ying-Jie Hao, Zhi-Nan Ren, Guang-Duo Zhu, Wei-Wei Zhou, Xu Lian, Xue-Jian Wu
The study aimed to investigate the effect of ginsenoside Rg1 on intervertebral disc degeneration (IVDD) in rats and IL-1β-induced nucleus pulposus (NP) cells, and explore its underlying mechanism. Forty IVDD rat models were divided into the IVDD group, low-dose (L-Rg1) group (intraperitoneal injection of 20 mg/kg/d ginsenoside Rg1), medium-dose (M-Rg1) group (intraperitoneal injection of 40 mg/kg/d ginsenoside Rg1), and high-dose (H-Rg1) group (intraperitoneal injection of 80 mg/kg/d ginsenoside Rg1)...
March 14, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38477401/a-novel-approach-combining-network-pharmacology-and-experimental-validation-to-study-the-protective-effect-of-ginsenoside-rb1-against-cantharidin-induced-hepatotoxicity-in-mice
#6
JOURNAL ARTICLE
Lijuan Xiong, Kexin Lin, Tianmu He, Xingyan Liu, Rui Yuan, Xiaofei Li, Jianyong Zhang
Cantharidin (CTD) is a widely used anticancer compound, but its clinical use is mainly limited due to hepatotoxicity. Ginsenoside Rb1 (GRb1) shows potential hepatoprotective effects. Nonetheless, the protective effect and underlying mechanism of GRb1 against CTD-induced hepatotoxicity in mice have not been investigated. This study aims to elucidate the effect and mechanism of GRb1 on CTD-induced hepatotoxicity using network pharmacology and in vivo experiments. Network pharmacology studies have shown that 263 targets were the main mechanisms by which GRb1 alleviates CTD-induced hepatotoxicity...
March 13, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38476921/therapeutic-effect-of-notoginseng-saponins-before-and-after-fermentation-on-blood-deficiency-rats
#7
JOURNAL ARTICLE
Wenjie Su, Zuguo Liang, Daian Pan, Lancao Zhang, Yuyao Zhang, Tongyi Yuan, Xiang Gao, Hang Su, He Zhang
Notoginseng saponins (NS) are the active ingredients in Panax notoginseng (Burk.) F.H. Chen (PN). NS can be transformed depending on how the extract is processed. Fermentation has been shown to produce secondary ginsenosides with increased bioavailability. However, the therapeutic effect of fermented NS (FNS) requires further study. The present study compared the compositions and activities of FNS and NS in blood deficiency rats, which resembles the symptoms of anemia in modern medicine, induced by acetylphenylhydrazine and cyclophosphamide...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476209/unveiling-the-experimental-proof-of-the-anticancer-potential-of-ginsenoside-rg3-review
#8
REVIEW
Yongmin Liu, Guanchu Li, Jinyue Ning, Yi Zhao
Ginsenoside Rg3 (GS-Rg3), a sterol molecule isolated from ginseng, has demonstrated various immunological properties, including inhibition of cancer cell proliferation and metastasis, reversal of drug resistance and enhancement of chemotherapy sensitivity. The recent surge in attention towards GS-Rg3 can be attributed to its potential as an antitumor angiogenesis agent and as a therapeutic candidate for immunotherapy. The development of GS-Rg3 as an agent for these purposes has accelerated research on its mechanisms of action...
April 2024: Oncology Letters
https://read.qxmd.com/read/38475452/transcriptome-wide-identification-and-integrated-analysis-of-a-ugt-gene-involved-in-ginsenoside-ro-biosynthesis-in-panax-ginseng
#9
JOURNAL ARTICLE
Xiaochen Yu, Jinghui Yu, Sizhang Liu, Mingming Liu, Kangyu Wang, Mingzhu Zhao, Yanfang Wang, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang
Panax ginseng as a traditional medicinal plant with a long history of medicinal use. Ginsenoside Ro is the only oleanane-type ginsenoside in ginseng, and has various pharmacological activities, including anti-inflammatory, detoxification, and antithrombotic activities. UDP-dependent glycosyltransferase (UGT) plays a key role in the synthesis of ginsenoside, and the excavation of UGT genes involved in the biosynthesis of ginsenoside Ro has great significance in enriching ginsenoside genetic resources and further revealing the synthesis mechanism of ginsenoside...
February 23, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38474620/ginsenoside-rb1-compound-k-and-20-s-protopanaxadiol-attenuate-high-fat-diet-induced-hyperlipidemia-in-rats-via-modulation-of-gut-microbiota-and-bile-acid-metabolism
#10
JOURNAL ARTICLE
Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao
Hyperlipidemia, characterized by elevated serum lipid concentrations resulting from lipid metabolism dysfunction, represents a prevalent global health concern. Ginsenoside Rb1, compound K (CK), and 20(S)-protopanaxadiol (PPD), bioactive constituents derived from Panax ginseng, have shown promise in mitigating lipid metabolism disorders. However, the comparative efficacy and underlying mechanisms of these compounds in hyperlipidemia prevention remain inadequately explored. This study investigates the impact of ginsenoside Rb1, CK, and PPD supplementation on hyperlipidemia in rats induced by a high-fat diet...
March 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474179/the-optimization-design-of-macrophage-membrane-camouflaging-liposomes-for-alleviating-ischemic-stroke-injury-through-intranasal-delivery
#11
JOURNAL ARTICLE
Tianshu Liu, Yan Wang, Mengfan Zhang, Jin Zhang, Naijin Kang, Linlin Zheng, Zhiying Ding
Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are currently lacking. In this study, we aimed to develop a novel nano delivery system to treat ischemic stroke via intranasal administration. A three-factor Box-Behnken experimental design was used to optimize the formulation of liposomes co-loaded with Panax notoginseng saponins (PNSs) and Ginsenoside Rg3 (Rg3) (Lip-Rg3/PNS). Macrophage membranes were coated onto the surface of the optimized liposomes to target the ischemic site of the brain...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471369/ginsenosides-from-panax-ginseng-as-potential-therapeutic-candidates-for-the-treatment-of-inflammatory-bowel-disease
#12
REVIEW
Zhiqiang Niu, Yanan Liu, Ruyi Shen, Xiaojian Jiang, Yanting Wang, Ziliang He, Junyao Li, Yeye Hu, Ji Zhang, Yunyao Jiang, Weicheng Hu, Chuanling Si, Shuai Wei, Ting Shen
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestine, which significantly affects patients' quality of life. As a perennial plant with the homology of medicine and food, Panax ginseng is known for its substantial anti-inflammatory effects in various inflammatory disorders. Ginsenosides, the main bioactive compounds of P. ginseng, are recognized for their efficacy in ameliorating inflammation. PURPOSE: Over the past decade, approximately 150 studies have investigated the effects of P...
February 23, 2024: Phytomedicine
https://read.qxmd.com/read/38471318/jiangu-formula-a-novel-osteoclast-osteoblast-coupling-agent-for-effective-osteoporosis-treatment
#13
JOURNAL ARTICLE
Huazhen Xu, Xiuli Lu, Mei Li, Xiaodan Huang, Nan Yao, Haining Gan, Xuejun Huang, Ziming Zhao, Zixuan Hu, Xinxin Zhao, Yijing Lai, Minyi Li, Shilong Chen, Yuxing Chen, Dane Huang
BACKGROUND: The discovering of an osteoclast (OC) coupling active agent, capable of suppressing OC-mediated bone resorption while concurrently stimulating osteoblast (OB)-mediated bone formation, presents a promising strategy to overcome limitations associated with existing antiresorptive agents. However, there is a lack of research on active OC coupling agents. PURPOSE: This study aims to investigate the potential of Jiangu Formula (JGF) in inhibiting OCs while maintaining the OCOB coupling function...
February 28, 2024: Phytomedicine
https://read.qxmd.com/read/38471317/ginseng-fermentation-solution-affects-the-gut-microbiota-in-zebrafish-with-alcoholic-liver-disease-via-pi3k-akt-pathway
#14
JOURNAL ARTICLE
Yongxi Wu, Shuhan Liu, Tao Ren, Liting Ma, Jing Luo, Meiyu Zhang, Fangtong Li, Yulin Dai, Fei Zheng, Zifeng Pi, Hao Yue
BACKGROUND: Ginsenosides have received increased amounts of attention due to their ability to modulate the intestinal flora, which may subsequently alleviate alcoholic liver disease (ALD). The effects of ginseng fermentation solution (GFS) on the gut microbiota and metabolism in ALD patients have not been explored. PURPOSE: This research aimed to explore the regulatory effect of GFS on ALD both in vitro and in vivo. METHOD: This study assessed the anti-ALD efficacy of GFS using an LO2 cell model and a zebrafish model...
February 27, 2024: Phytomedicine
https://read.qxmd.com/read/38469409/the-protective-role-of-ginsenoside-rg3-in-heart-diseases-and-mental-disorders
#15
REVIEW
Lili Shi, Jinlan Luo, Xiupan Wei, Xizhen Xu, Ling Tu
Ginsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a novel approach to therapy. Mental illnesses are significant contributors to global disease mortality, and there is a well-established correlation between cardiac and psychiatric conditions. This connection is primarily due to dysfunctions in the sympathetic-adrenomedullary system (SAM), the hypothalamic-pituitary-adrenal axis, inflammation, oxidative stress, and brain-derived neurotrophic factor impairment...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38469323/suspension-cell-cultures-of-panax-vietnamensis-as-a-biotechnological-source-of-ginsenosides-growth-cytology-and-ginsenoside-profile-assessment
#16
JOURNAL ARTICLE
Maria V Titova, Maria K Lunkova, Tatiana M Tyurina, Olga N Prudnikova, Elena V Popova, Oleg I Klychnikov, Pavel S Metalnikov, Yuri A Ikhalaynen, Elizaveta N Vasileva, Igor A Rodin, Alexander M Nosov
INTRODUCTION: Panax vietnamensis is a valuable medicinal plant and a source of a broad spectrum of biologically active ginsenosides of different structural groups. Overexploitation and low adaptability to planation cultivation have made this species vulnerable to human pressure and prompted the development of cell cultivation in vitro as a sustainable alternative to harvesting wild plants for their bioactive components. Despite high interest in biotechnological production, little is known about the main factors affecting cell growth and ginsenoside biosynthesis of this species under in vitro conditions...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38465430/ginsenoside-rb1-inhibits-the-proliferation-of-lung-cancer-cells-by-inducing-the-mitochondrial-mediated-apoptosis-pathway
#17
JOURNAL ARTICLE
Lin Feng, Xinze Liu, Kaijing Sun, Ying Sun, Wei Wu, Changbao Chen, Xin Jin, Xilin Wan
BACKGROUND: Lung cancer is one of the more common malignant tumors posing a great threat to human life, and it is very urgent to find safe and effective therapeutic drugs. The antitumor effect of ginsenosides has been reported to be a treatment with a strong effect and a high safety profile. OBJECTIVE: This paper aimed to investigate the inhibitory effect of ginsenoside Rb1 on 95D and NCI-H460 lung cancer cells and its pathway to promote apoptosis. METHODS: We performed the CCK-8 assay, fluorescence staining assay, flow cytometry, scratch healing assay, and Transwell assay to detect the effects of different concentrations of ginsenoside Rb1 on the antitumor activity of 95D and NCI-H460 cells and Western Blot detected the mechanism of antitumor effect...
March 7, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38465223/mass-spectrometry-based-ginsenoside-profiling-recent-applications-limitations-and-perspectives
#18
REVIEW
Hyun Woo Kim, Dae Hyun Kim, Byeol Ryu, You Jin Chung, Kyungha Lee, Young Chang Kim, Jung Woo Lee, Dong Hwi Kim, Woojong Jang, Woohyeon Cho, Hyeonah Shim, Sang Hyun Sung, Tae-Jin Yang, Kyo Bin Kang
Ginseng, the roots of Panax species, is an important medicinal herb used as a tonic. As ginsenosides are key bioactive components of ginseng, holistic chemical profiling of them has provided many insights into understanding ginseng. Mass spectrometry has been a major methodology for profiling, which has been applied to realize numerous goals in ginseng research, such as the discrimination of different species, geographical origins, and ages, and the monitoring of processing and biotransformation. This review summarizes the various applications of ginsenoside profiling in ginseng research over the last three decades that have contributed to expanding our understanding of ginseng...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465222/differential-antiangiogenic-and-anticancer-activities-of-the-active-metabolites-of-ginsenoside-rg3
#19
JOURNAL ARTICLE
Maryam Nakhjavani, Eric Smith, Kenny Yeo, Yoko Tomita, Timothy J Price, Andrea Yool, Amanda R Townsend, Jennifer E Hardingham
BACKGROUND: Epimers of ginsenoside Rg3 (Rg3) have a low bioavailability and are prone to deglycosylation, which produces epimers of ginsenoside Rh2 (S-Rh2 and R-Rh2) and protopanaxadiol (S-PPD and R-PPD). The aim of this study was to compare the efficacy and potency of these molecules as anti-cancer agents. METHODS: Crystal violet staining was used to study the anti-proliferatory action of the molecules on a human epithelial breast cancer cell line, MDA-MB-231, and human umbilical vein endothelial cells (HUVEC) and compare their potency...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38465221/ginsenoside-rg1-promotes-neurite-growth-of-retinal-ganglion-cells-through-camp-pka-creb-pathways
#20
JOURNAL ARTICLE
Ye-Ying Jiang, Rong-Yun Wei, Kai Tang, Zhen Wang, Ning-Hua Tan
BACKGROUND: Mechanisms of synaptic plasticity in retinal ganglion cells (RGCs) are complex and the current knowledge cannot explain. Growth and regeneration of dendrites together with synaptic formation are the most important parameters for evaluating the cellular protective effects of various molecules. The effect of ginsenoside Rg1 (Rg1) on the growth of retinal ganglion cell processes has been poorly understood. Therefore, we investigated the effect of ginsenoside Rg1 on the neurite growth of RGCs...
March 2024: Journal of Ginseng Research
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