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https://www.readbyqxmd.com/read/28329914/ginsenoside-rg3-restores-hepatitis-c-virus-induced-aberrant-mitochondrial-dynamics-and-inhibits-virus-propagation
#1
Seong-Jun Kim, Jae Young Jang, Eun-Jung Kim, Eun Kyung Cho, Dae Gyun Ahn, Chonsaeng Kim, Han Seul Park, Soung Won Jeong, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Hong Soo Kim, Boo Sung Kim, Ji-Hyung Lee, Aleem Siddiqui
Hepatitis C virus (HCV) alters mitochondrial dynamics associated with persistent viral infection and suppression of innate immunity. Mitochondrial dysfunction is also a pathologic feature of direct-acting antiviral (DAA) treatment. Despite the high efficacy of DAAs, their treatment of patients with chronic hepatitis C in interferon-sparing regimens occasionally produces undesirable side effects such as fatigue, migraine and other conditions, which may be linked to mitochondrial dysfunction. Here we show that clinically prescribed DAAs, including Sofosbuvir, affect mitochondrial dynamics...
March 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28327605/ginsenoside-rb1-protects-against-ischemia-reperfusion-induced-myocardial-injury-via-energy-metabolism-regulation-mediated-by-rhoa-signaling-pathway
#2
Yuan-Chen Cui, Chun-Shui Pan, Li Yan, Lin Li, Bai-He Hu, Xin Chang, Yu-Ying Liu, Jing-Yu Fan, Kai Sun, Quan -Li, Jing-Yan Han
Cardiac ischemia and reperfusion (I/R) injury remains a challenge for clinicians. Ginsenoside Rb1 (Rb1) has been reported to have the ability to attenuate I/R injury, but its effect on energy metabolism during cardiac I/R and the underlying mechanism remain unknown. In this study, we detected the effect of Rb1 on rat myocardial blood flow, myocardial infarct size, cardiac function, velocity of venule red blood cell, myocardial structure and apoptosis, energy metabolism and change in RhoA signaling pathway during cardiac I/R injury...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314255/anti-metastatic-efficacy-of-traditional-chinese-medicine-tcm-ginsenoside-conjugated-to-a-vefgr-3-antibody-on-human-gastric-cancer-in-an-orthotopic-mouse-model
#3
Xiaojun Dai, Dongmei Liu, Moxiang Liu, Xiaochun Zhang, Weiming Wang, Feng Jin, Yayun Qian, Xuanyi Wang, Jingjing Zhao, Yongjian Wu, Fangfang Xiong, N A Chang, Y U Sun, Zhijian Yang, Robert M Hoffman, Yanqing Liu
Background/Aim: The aim of the present study was to investigate the efficacy of a traditional Chinese medicine (TCM), VEGFR-3 antibody-conjugated ginsenoside Rg3nanoemulsion (VRIN), targeting lymphangiogenesis, on the inhibition of tumor growth and metastasis in an orthotopic mouse model of human gastric cancer. Materials and Methods: An orthotopic nude-mouse model of gastric cancer was established with the red fluorescent protein (RFP)-expressing human gastric cancer cell line NUGC-4-RFP. The tumor-bearing mice were treated with vehicle (0...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28314104/ginsenoside-re-ameliorates-brain-insulin-resistance-and-cognitive-dysfunction-in-high-fat-diet-induced-c57bl-6-mice
#4
Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae Ok Kim, Ho Jin Heo
The ameliorating effects of ginsenoside Re (G Re) on high-fat diet (HFD)-induced insulin resistance in C57BL/6 mice were investigated to assess its physiological function. In the results of behavioral tests, G Re improved cognitive dysfunction on diabetic mice using Y-maze, passive avoidance and Morris water maze tests. G Re also significantly recovered hyperglycemia and fasting blood glucose level. In the results of serum analysis, G Re decreased triglyceride (TG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDLC), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT), and increased the ratio of high density lipoprotein cholesterol (HDLC)...
March 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28301605/ocf-can-repress-tumor-metastasis-by-inhibiting-epithelial-mesenchymal-transition-involved-in-pten-pi3k-akt-pathway-in-lung-cancer-cells
#5
Ye Yang, Shuang Qiu, Lei Qian, Yuan Tian, Yingna Chen, Lei Bi, Weiping Chen
A component formula with definite compositions provides a new approach to treat various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China because of their antitumor properties. In the previous study, the optimizing component formula (OCF), prepared with salvianolic acids, ginsenosides, and ginseng polysaccharides (5, 10, and 5 mg·L-1, respectively) extracted from S. miltiorrhiza and P. ginseng on the basis of IC50 in lung cancer A549 cells and damage minimization on human bronchial epithelial cells in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28297748/bioconversion-using-lactic-acid-bacteria-ginsenosides-gaba-and-phenolic-compounds
#6
REVIEW
Na-Kyoung Lee, Hyun-Dong Paik
Lactic acid bacteria (LAB) are used as fermentation starters in vegetable and dairy products and influence the pH and flavors of foods. For many centuries, LAB have been used to manufacture fermented foods; therefore, they are generally regarded as safe. LAB produce various substances such as lactic acid, β-glucosidase, or β-galactosidase, making them useful as fermentation starters. Existing functional substances have been tried as fermentation substrates for better bioavailability or other functions. Representative materials that were bioconverted using LAB have been reported and include minor ginsenoside, γ-amino butyric acid, equol, aglycone, bioactive isoflavones, genistein, daidzein, and others...
March 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28294969/a-metabolomic-approach-for-the-discrimination-of-red-ginseng-root-parts-and-targeted-validation
#7
Gyo In, Hyun Kyu Seo, Hee-Won Park, Kyoung Hwa Jang
Ginsenosides are used as existing markers of red ginseng (RG) quality, and ginsenoside ratios are also indicative of the different components of red ginseng. For the analysis and classification of ginsenoside content, red ginseng was separated into three parts, namely, main roots, lateral roots, and fine roots, and each extract was subjected to ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed a clear discrimination between the extracts of main roots and fine roots and suggested discrimination markers (four for the main roots and five for the fine roots)...
March 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28289387/analyses-of-mrna-profiling-through-rna-sequencing-on-a-samp8-mouse-model-in-response-to-ginsenoside-rg1-and-rb1-treatment
#8
Shuai Zhang, Dina Zhu, Hong Li, Haijing Zhang, Chengqiang Feng, Wensheng Zhang
Ginsenoside Rg1 and Rb1 are the major ingredients in two medicines called QiShengLi (Z20027165) and QiShengJing (Z20027164) approved by China. These ingredients are believed to mitigate forgetfulness. Numerous studies have confirmed that GRg1 and GRb1 offer protection against Alzheimer's disease (AD), and our morris water maze (MWM) experiment also indicated that GRg1 and GRb1 may attenuate memory deficits in the 7-month-old SAMP8 mice; however, comprehensive understanding of their roles in AD remains limited...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28287442/a-strategy-for-simultaneous-isolation-of-less-polar-ginsenosides-including-a-pair-of-new-20-methoxyl-isomers-from-flower-buds-of-panax-ginseng
#9
Sha-Sha Li, Ke-Ke Li, Fei Xu, Li Tao, Li Yang, Shu-Xiao Chen, Xiao-Jie Gong
The present study was designed to simultaneously isolate the less polar ginsenosides from the flower buds of Panax ginseng (FBPG). Five ginsenosides, including a pair of new 20-methoxyl isomers, were extracted from FBPG and purified through a five-step integrated strategy, by combining ultrasonic extraction, Diaion Hp-20 macroporous resin column enrichment, solid phase extraction (SPE), reversed-phase high-performance liquid chromatography (RP-HPLC) analysis and preparation, and nuclear magnetic resonance (NMR) analysis...
March 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28287423/chondroprotective%C3%A2-effects%C3%A2-of%C3%A2-ginsenoside%C3%A2-rg1%C3%A2-in%C3%A2-human%C3%A2-osteoarthritis%C3%A2-chondrocytes%C3%A2-and%C3%A2-a%C3%A2-rat%C3%A2-model%C3%A2-of%C3%A2-anterior%C3%A2-cruciate%C3%A2-ligament%C3%A2-transection
#10
Wendan Cheng, Juehua Jing, Zhen Wang, Dongying Wu, Yumin Huang
This study aimed to assess whether Ginsenoside Rg1 (Rg1) inhibits inflammatory responses in human chondrocytes and reduces articular cartilage damage in a rat model of osteoarthritis (OA). Gene expression and protein levels of type II collagen, aggrecan, matrix metalloproteinase (MMP)-13 and cyclooxygenase-2 (COX-2) were determined in vitro by quantitative real-time-polymerase chain reaction and Western blotting. Prostaglandin E2 (PGE2) amounts in the culture medium were determined by enzyme-linked immunosorbent assay (ELISA)...
March 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28285072/purity-assessment-of-ginsenoside-rg1-using-quantitative-1-h-nuclear-magnetic-resonance
#11
Bao-Ming Huang, Sheng-Yuan Xiao, Ting-Bo Chen, Ying Xie, Pei Luo, Liang Liu, Hua Zhou
Ginseng herbs comprise a group of the most popular herbs, including Panax ginseng, P. notoginseng and P. quinquefolius (Family Araliaceae), which are used as traditional Chinese medicine (TCM) and are some of the best-selling natural products in the world. The accurate quantification of ginsenoside Rg1 is one of the major aspects of its quality control. However, the purity of the commercial Rg1 chemical reference substance (CRS) is often measured with high-performance chromatography coupled with an ultraviolet detector (HPLC-UV), which is a selective detector with unequal responses to different compounds; thus, this detector introduces probable error to purity assessments...
March 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28280902/ginsenoside-rg5-attenuates-hepatic-glucagon-response-via-suppression-of-succinate-associated-hif-1%C3%AE-induction-in-hfd-fed-mice
#12
Na Xiao, Meng-Die Lou, Yi-Tong Lu, Le-Le Yang, Qun Liu, Baolin Liu, Lian-Wen Qi, Ping Li
AIMS/HYPOTHESIS: Ginsenosides regulate glucose homeostasis. This study investigated the effect of ginsenoside Rg5 (Rg5) on the hepatic glucagon response, focusing on the regulation of metabolism. METHODS: Mice fed a high-fat diet (HFD) showed increased hepatic glucose production (HGP). We observed the effects of Rg5 on hepatic fatty acid oxidation and glucagon response. The regulation of phosphodiesterase (PDE) 4B by succinate was also investigated in hepatocytes...
March 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/28278662/antimicrobial-activity-of-saponins-produced-by-two-novel-endophytic-fungi-from-panax-notoginseng
#13
Zhaoxia Jin, Lin Gao, Lin Zhang, Tianyi Liu, Fang Yu, Zongshen Zhang, Qiong Guo, Biying Wang
Endophytes in plants may be co-producer of the bioactive compounds of their hosts. We conducted a study to bioprospect for saponin-producing endophytic fungi from Panax notoginseng and evaluate the antimicrobial activity of saponins. Two novel fungal endophytes, Fusarium sp. PN8 and Aspergillus sp. PN17, were isolated from traditional Chinese medicinal herb P. notoginseng. After eight days of fermentation, the total saponins produced in the culture broth of PN8 and PN17 were 1.061 and 0.583 mg mL(-1), respectively...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28273939/microbial-transformation-of-ginsenoside-rb1-re-and-rg1-and-its-contribution-to-the-improved-anti-inflammatory-activity-of-ginseng
#14
Shanshan Yu, Xiaoli Zhou, Fan Li, Chunchun Xu, Fei Zheng, Jing Li, Huanxi Zhao, Yulin Dai, Shuying Liu, Yan Feng
Microbial transformation of ginsenosides to increase its pharmaceutical effect is gaining increasing attention in recent years. In this study, Cellulosimicrobium sp. TH-20, which was isolated from soil samples on which ginseng grown, exhibited effective ginsenoside-transforming activity. After protopanaxadiol (PPD)-type ginsenoside (Rb1) and protopanaxatriol (PPT)-type ginsenosides (Re and Rg1) were fed to C. sp. TH20, a total of 12 metabolites, including 6 new intermediate metabolites, were identified. Stepwise deglycosylation and dehydrogenation on the feeding precursors have been observed...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261091/ginsenoside-rg5-inhibits-succinate-associated-lipolysis-in-adipose-tissue-and-prevents-muscle-insulin-resistance
#15
Na Xiao, Le-Le Yang, Yi-Lin Yang, Li-Wei Liu, Jia Li, Baolin Liu, Kang Liu, Lian-Wen Qi, Ping Li
Endoplasmic reticulum (ER) stress, inflammation, and lipolysis occur simultaneously in adipose dysfunction and contribute to insulin resistance. This study was designed to investigate whether ginsenoside Rg5 could ameliorate adipose dysfunction and prevent muscle insulin resistance. Short-term high-fat diet (HFD) feeding induced hypoxia with ER stress in adipose tissue, leading to succinate accumulation due to the reversal of succinate dehydrogenase (SDH) activity. Rg5 treatment reduced cellular energy charge, suppressed ER stress and then prevented succinate accumulation in adipose tissue...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28260016/effects-of-r-type-and-s-type-ginsenoside-rg3-on-dna-methylation-in-human-hepatocarcinoma-cells
#16
Siying Teng, Yi Wang, Pingya Li, Jinhua Liu, Anhui Wei, Haotian Wang, Xiangkun Meng, Di Pan, Xinmin Zhang
Ginsenoside Rg3, a bioactive constituent isolated from Panax ginseng, exhibits antitumorigenic, antioxidative, antiangiogenic, neuroprotective and other biological activities are associated with the regulation of multiple genes. DNA methylation patterns, particularly those in the promoter region, affect gene expression, and DNA methylation is catalyzed by DNA methylases. However, whether ginsenoside Rg3 affects DNA methylation is unknown. High performance liquid chromatography assay, MspI/HpaII polymerase chain reaction (PCR) and reverse transcription‑quantitative PCR were performed to assess DNA methylation...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28257788/antidepressant-like-effects-of-ginsenoside-rg5-in-mice-involving-of-hippocampus-bdnf-signaling-pathway
#17
Dawei Xu, Chengniu Wang, Wei Zhao, Shengfeng Gao, Zhiming Cui
Ginsenoside Rg5 is one of the major bioactive ingredients of Panax ginseng with little toxicity and has been shown to have pharmacological effects on the central nervous system. In this study, we investigated the antidepressant effects of Rg5 in mice models of depression. The effects of Rg5 were first assessed in the forced swimming test (FST) and tail suspension test (TST), and then investigated in the chronic social defeat stress (CSDS) model of depression. The changes in hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and Rg5 treatment were also examined...
March 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28257666/pharmacokinetic-herb-drug-interaction-of-xuesaitong-dispersible-tablet-and-aspirin-after-oral-administration-in-blood-stasis-model-rats
#18
Guoliang Dai, Zhitao Jiang, Yongtao Bai, Qian Zhang, Lei Zhu, Xiaohui Bai, Wenzheng Ju, Ronghua Pan
BACKGROUND: Xuesaitong dispersible tablet (XST) product has been clinically proven to be effective for treating cardio-cerebrovascular disease. Furthermore, herb-drug interactions between the XST product and drugs that are commonly co-administered, such as aspirin (ASA), must be explored to ensure safe clinical use. STUDY DESIGN AND METHODS: The current study aims to investigate whether the XST product interacts with ASA when they are administered concomitantly to ensure safety and efficacy...
March 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28256039/biotransformation-of-ginsenoside-rb1-to-ginsenoside-rg3-by-endophytic-bacterium-burkholderia-sp-ge-17-7-isolated-from-panax-ginseng
#19
Yu Fu, Zhenhao Yin, Chengri Yin
AIMS: To isolate a novel endophytic bacteriums from Panax ginseng that could have excellent properties on converting ginsenoside Rb1 to ginsenoside Rg3. METHODS AND RESULTS: Based on 16S rDNA gene sequence, the strain named GE 17-7 was identified as Burkholderia sp. This strain have showed the highest activity in convertion ginsenosides Rb1 into 20(S)-ginsenoside Rg3. During the biotransformation of ginsenoside Rb1, the final metabolite was identified by Nuclear Magnetic Resonance (NMR) analysis and the transformation pathway of ginsenoside Rb1 was also identified by Thin-layer chromatography (TLC) and high performance liquid chromatography (HPLC) analysis in this study...
March 3, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28244297/therapeutic-effects-of-korean-red-ginseng-extract-in-a-murine-model-of-atopic-dermatitis-anti-pruritic-and-anti-inflammatory-mechanism
#20
Hyun Joo Lee, Sang Hyun Cho
Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, including anti-inflammatory and anti-allergic. We aimed to investigate the therapeutic effect of KRG in a murine model of atopic dermatitis (AD) is mediated whether by diminishing the pruritus or by suppressing the inflammation. Thirty NC/Nga mice were randomly divided to 5 groups. AD-like skin lesions were induced by percutaneous challenge with 2,4,6-trinitro-1-chrolobenzene (TNCB) on the ears and backs of NC/Nga mice. KRG extract, evening primrose oil, cyclosporine, and phosphate-buffered saline were administered orally by a gastric tube...
April 2017: Journal of Korean Medical Science
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