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https://www.readbyqxmd.com/read/28534996/ginsenoside-rd-regulates-the-akt-mtor-p70s6k-signaling-cascade-and-suppresses-angiogenesis-and-breast-tumor-growth
#1
Eryun Zhang, Hailian Shi, Li Yang, Xiaojun Wu, Zhengtao Wang
Blockade of angiogenesis is an important approach for cancer treatment and prevention. In the present study, we investigated the effect of ginsenoside Rd (Rd) on angiogenesis in vitro and in vivo. Our results demonstrated that Rd inhibited vascular endothelial growth factor (VEGF)-induced migration, tube formation and proliferation of primary cultured human umbilical vascular endothelial cells (HUVECs) dose‑dependently. Furthermore, Rd abrogated VEGF-induced sprouting of the vessels from aortic rings, and inhibited vascular formation in the Matrigel plug assay in vivo...
May 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28534845/enhanced-production-of-gypenoside-lxxv-using-a-novel-ginsenoside-transforming-%C3%AE-glucosidase-from-ginseng-cultivating-soil-bacteria-and-its-anti-cancer-property
#2
Chang-Hao Cui, Da Jung Kim, Suk-Chae Jung, Sun-Chang Kim, Wan-Taek Im
Minor ginsenosides, such as compound K, Rg₃(S), which can be produced by deglycosylation of ginsenosides Rb₁, showed strong anti-cancer effects. However, the anticancer effects of gypenoside LXXV, which is one of the deglycosylated shapes of ginsenoside Rb₁, is still unknown due to the rarity of its content in plants. Here, we cloned and characterized a novel ginsenoside-transforming β-glucosidase (BglG167b) derived from Microbacterium sp. Gsoil 167 which can efficiently hydrolyze gypenoside XVII into gypenoside LXXV, and applied it to the production of gypenoside LXXV at the gram-scale with high specificity...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534819/ginsenoside-rb2-alleviates-hepatic-lipid-accumulation-by-restoring-autophagy-via-induction-of-sirt1-and-activation-of-ampk
#3
Qi Huang, Ting Wang, Liu Yang, He-Yao Wang
Although Panax ginseng is a famous traditional Chinese medicine and has been widely used to treat a variety of metabolic diseases including hyperglycemia, hyperlipidemia, and hepatosteatosis, the effective mediators and molecular mechanisms remain largely unknown. In this study we found that ginsenoside Rb2, one of the major ginsenosides in Panax ginseng, was able to prevent hepatic lipid accumulation through autophagy induction both in vivo and in vitro. Treatment of male db/db mice with Rb2 significantly improved glucose tolerance, decreased hepatic lipid accumulation, and restored hepatic autophagy...
May 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28534811/hormetic-property-of-ginseng-steroids-on-anti-oxidant-status-against-exercise-challenge-in-rat-skeletal-muscle
#4
Ming-Fen Hsu, Szu-Hsien Yu, Mallikarjuna Korivi, Wei-Horng Jean, Shin-Da Lee, Chih-Yang Huang, Yi-Hung Liao, Jessica Lu, Chia-Hua Kuo
BACKGROUND: Existing literature on anti-oxidant capacity of ginseng has been inconsistent due to variance in the profile of ginseng steroids (Ginsenosides) that is because of differences in seasons and species. METHODS: We used various doses of ginseng steroids to determine its effect on oxidative stress and anti-oxidant capacity of rat skeletal muscle against exercise. RESULTS: Under non-exercise conditions, we found increased thiobarbituric acid reactive substance (TBARS) levels and decreased reduced/oxidized glutathione ratio (GSH/GSSG) in rat skeletal muscle as dose increases (p < 0...
May 19, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28532223/preliminary-study-on-fabrication-characterization-and-synergistic-anti-lung-cancer-effects-of-self-assembled-micelles-of-covalently-conjugated-celastrol-polyethylene-glycol-ginsenoside-rh2
#5
Peng Li, XiaoYue Zhou, Ding Qu, Mengfei Guo, Chenyi Fan, Tong Zhou, Yang Ling
The aim of this study was to develop an amphipathic polyethylene glycol (PEG) derivative that was bi-terminally modified with celastrol and ginsenoside Rh2 (Celastrol-PEG-G Rh2). Such derivative was capable of forming novel, celastrol-loaded polymeric micelles (CG-M) for endo/lysosomal delivery and thereby synergistic treatment of lung cancer. Celastrol-PEG-G Rh2 with a yield of 55.6% was first synthesized and characterized. Its critical micellar concentration was 1 × 10(-5 )M, determined by pyrene entrapment method...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28525898/ginsenoside-rg3-inhibits-the-senescence-of-prostate-stromal-cells-through-down-regulation-of-interleukin-8-expression
#6
Yanfei Peng, Ran Zhang, Lingfei Kong, Yongmei Shen, Da Xu, Fang Zheng, Jianwei Liu, Qian Wu, Bona Jia, Ju Zhang
Senescent stromal cells support the development of prostate cancer and are considered potential therapeutic targets. This research evaluated the regulatory effects of ginsenoside Rg3 on the senescence of prostatic stromal cells pre-incubated in medium supplemented with 0.5% fetal bovine serum. The results revealed that ginsenoside Rg3 decreased the number of stromal cells positively stained with a senescent cell marker (senescence-associated β-galactosidase). Ginsenoside Rg3 also increased the viability of stromal cells and promoted cell cycle transition from G0/G1 to S phase, as well as inhibited the carcinoma-associated fibroblast-like phenotype in prostate stromal cells, through the up-regulation of smooth muscle cell markers SM22 and smooth muscle myosin heavy chain...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523344/role-of-g3bp1-in-glucocorticoid-receptor-mediated-microrna-15b-and-microrna-23a-biogenesis-in-endothelial-cells
#7
Hoi-Hin Kwok, Po-Ying Poon, Kylie Hin-Man Mak, Lin-Yao Zhang, Pei Liu, Huoming Zhang, Nai-Ki Mak, Patrick Ying-Kit Yue, Ricky Ngok-Shun Wong
MicroRNAs (miRNAs) are a family of non-coding RNAs that play crucial roles in regulating various normal cellular responses. Recent studies revealed that the canonical miRNA biogenesis pathway is subject to sophisticated regulation. Hormonal control of miRNA biogenesis by androgen and estrogen has been demonstrated, but the direct effects of the glucocorticoid receptor (GR) on miRNA biogenesis are unknown. This study revealed the role of GR in miRNA maturation. We showed that two GR agonists, dexamethasone and ginsenoside-Rg1 rapidly suppressed the expression of mature miR-15b, miR-23a, and miR-214 in human endothelial cells...
May 18, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28505464/treatment-of-the-cardiac-hypertrophic-response-and-heart-failure-with-ginseng-ginsenosides-and-ginseng-related-products
#8
Morris Karmazyn, Tracey Gan
Heart failure is a major medical as well as economic burden throughout the world. Although various treatment options are available to treat heart failure, death rates in both men and women remain high. Potential adjunctive therapies may lie with use of herbal medications many of which possess potent pharmacological properties. Among the most widely studied is ginseng, a member of the genus Panax which is grown in many parts of the world and which has been used as a medical treatment for a variety of conditions for thousands of years, particularly in Asian societies...
May 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28485547/pseudoginsenoside-f11-attenuates-cerebral-ischemic-injury-by%C3%A2-alleviating-autophagic-lysosomal-defects
#9
Yue-Yang Liu, Tian-Yu Zhang, Xue Xue, Dong-Mei Liu, Hao-Tian Zhang, Lin-Lin Yuan, Ying-Lu Liu, Han-Lin Yang, Shi-Bo Sun, Cheng Zhang, He-Song Xu, Chun-Fu Wu, Jing-Yu Yang
AIMS: Pseudoginsenoside-F11 (PF11), an ocotillol-type ginsenoside, has been reported to exert wide-ranging neuroprotective properties. The aim of this study was to investigate the effect and potential mechanisms of PF11 on the autophagic/lysosomal pathway following ischemic stroke. METHODS: Male Sprague-Dawley rats underwent permanent middle cerebral artery occlusion (pMCAO). Cerebral ischemia outcome, TUNEL staining, Fluoro-Jade B staining were carried out 24 hours poststroke...
May 9, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28482410/-therapeutic-efficacy-and-mechanism-of-action-of-ginsenoside-rg1-in-treating-acute-hepatic-failure-in-mice
#10
H Luo, W X Huang, C Yang, J Q Zhao, S Liu, Y S Xu, C W Liu
Objective: To examine the regulatory effect of ginsenoside Rg1 (G-Rg1) on endoplasmic reticulum stress and its effect on hepatocellular apoptosis in carbon tetrachloride (CCl(4))-induced acute liver failure (ALF). Methods: Forty healthy, adult male C57/BL mice were randomly divided into normal saline control (NS) group, G-Rg1 blank control (G-Rg1) group, CCl(4) model (CCl(4)) group, and G-Rg1 preventive treatment (CCl(4)+G-Rg1) group, and an ALF mouse model was established by CCl(4) induction. Blood and liver specimens were collected from all mice upon sacrifice at 12 hours post-intraperitoneal injection...
March 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28479739/preparation-of-ginseng-extract-with-enhanced-levels-of-ginsenosides-rg1-and-rb1-using-high-hydrostatic-pressure-and-polysaccharide-hydrolases
#11
Sasikumar Arunachalam Palaniyandi, Joo-Won Suh, Seung Hwan Yang
BACKGROUND: Ginsenosides are the principal components responsible for the pharmacological activities of ginseng. Ginsenosides Rg1 and Rb1 are the major compounds recognized as marker substances for quality control of ginseng-based products. These major compounds can be transformed to several pharmacologically active minor ginsenosides by chemical, microbial, and enzymatic means. MATERIALS AND METHODS: In the present study, a combination of polysaccharide hydrolases and high hydrostatic pressure (HHP) were used to extract ginseng saponins enriched with ginsenosides Rg1 and Rb1...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28479731/simultaneous-determination-of-multiple-ginsenosides-in-panax-ginseng-herbal-medicines-with-one-single-reference-standard
#12
Chunwei Wu, Qingxiao Guan, Shumei Wang, Yueying Rong
BACKGROUND: Root of Panax ginseng C. A. Mey (Renseng in Chinese) is a famous Traditional Chinese Medicine. Ginsenosides are the major bioactive components. However, the shortage and high cost of some ginsenoside reference standards make it is difficult for quality control of P. ginseng. OBJECTIVE: A method, single standard for determination of multicomponents (SSDMC), was developed for the simultaneous determination of nine ginsenosides in P. ginseng (ginsenoside Rg1, Re, Rf, Rg2, Rb1, Rc, Rb2, Rb3, Rd)...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28479190/biosynthesis-of-plant-derived-ginsenoside-rh2-in-yeast-via-repurposing-a-key-promiscuous-microbial-enzyme
#13
Yu Zhuang, Guangyu Yang, Xiaohui Chen, Qian Liu, Xueli Zhang, Zixin Deng, Yan Feng
Ginsenoside Rh2 is a potential anticancer drug isolated from medicinal plant ginseng. Fermentative production of ginsenoside Rh2 in yeast has recently been investigated as an alternative strategy compared to extraction from plants. However, the titer was quite low due to low catalytic capability of the key ginseng glycosyltransferase in microorganisms. Herein, we have demonstrated high-level production of ginsenoside Rh2 in Saccharomyces cerevisiae via repurposing an inherently promiscuous glycosyltransferase, UGT51...
May 4, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28478866/inhibition-of-amyloid-%C3%AE-aggregation-and-protective-effect-on-sh-sy5y-cells-by-triterpenoid-saponins-from-the-cactus-polaskia-chichipe
#14
Koji Fujihara, Shin Koike, Yuki Ogasawara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshita
Alzheimer's disease (AD) destroys brain function, especially in the hippocampus, and is a social problem worldwide. A major pathogenesis of AD is related to the accumulation of amyloid beta (Aβ) peptides, resulting in neuronal cell death in the brain. Here, we isolated four saponins (1-4) and elucidated their structures from 1D and 2D NMR and HRFABMS spectral data. The structures of 1 and 2 were determined as new saponins which have cochalic acid as the aglycon, and 3 was determined as a new saponin with oleanolic acid as the aglycon...
April 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28474065/-ginsenoside-rg1-regulates-the-proliferation-and-migration-of-human-periodontal-ligament-cells-via-akt-enos-signaling-under-nicotine-stress
#15
Cai-Hong Liu, Li DU
PURPOSE: To explore the effects and molecular mechanisms of ginsenoside Rg1 on the proliferation and migration of human periodontal ligament cells (HPDLCs) under nicotine stress. METHODS: HPDLCs were isolated and cultured by method of explant cell culture. The cells were cultured under nicotine stress for 7 days, and treated respectively with ginsenoside Rg1 (0.01 μmol/L), ginsenoside Rg1 and LY294002 (PI3K inhibitor, 0.5 μmol/L), ginsenoside Rg1 and Tricirbine (Akt inhibitor, 5 μmol/L), ginsenoside Rg1 and L-NAME (Akt inhibitor, 1 mmol/L) from 3rd day after nicotine stress to 7th day...
February 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28471389/dynamic-changes-in-neutral-and-acidic-ginsenosides-with-different-cultivation-ages-and-harvest-seasons-identification-of-chemical-characteristics-for-panax-ginseng-quality-control
#16
Zhi Liu, Chong-Zhi Wang, Xing-You Zhu, Jin-Yi Wan, Jing Zhang, Wei Li, Chang-Chun Ruan, Chun-Su Yuan
In this study, dynamic changes in ginsenoside content and ratios in the Panax ginseng root were investigated with different cultivation ages and different collection months, using high-performance liquid chromatography (HPLC). Our data indicate that changes in ginsenoside Ro and malonyl ginsenosides content were dependent on the ginseng cultivation age (p < 0.05); especially, the Ro content varied from 0.16 to 4.91 mg/g, with a difference about 30-fold. Further, we found that the samples of 5 and 6-year-old P...
May 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28471118/ginsenoside-rg1-promotes-neural-differentiation-of-mouse-adipose-derived-stem-cells-via-the-mirna-124-signaling-pathway
#17
Juan Dong, Guo Zhu, Tian-Cheng Wang, Fu-Shan Shi
We have explored the role of ginsenoside Rg1 in promoting the differentiation of mouse adipose-derived stem cells (mADSC) towards the neuronal lineage. The central nervous system has long been regarded as incapable of self-repair; therefore neuronal differentiation from stem cells is of great interest. However, the use of embryonic stem cells is limited due to their inaccessibility and for ethical reasons, so the search is on for alternative pluripotent cells capable of differentiating into neuronal cells. Adipose-derived stem cells (ADSC) can differentiate into different cell types, including neuronal cells: their accessibility, low risk, and capacity for long-term growth and self-renewal have made them the preferred stem cell type for clinical applications...
May 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28468295/chemical-comparison-of-two-drying-methods-of-mountain-cultivated-ginseng-by-uplc-qtof-ms-ms-and-multivariate-statistical-analysis
#18
Xin-Fang Xu, Shu-Ya Xu, Ying Zhang, Hui Zhang, Meng-Nan Liu, Huan Liu, Yan Gao, Xue Xue, Hui Xiong, Rui-Chao Lin, Xiang-Ri Li
In traditional Chinese medicine practice, drying method is an essential factor to influence the components of Chinese medicinal herbs. In this study, an ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS/MS)-based approach was used to compare the content of chemical compounds of mountain cultivated ginseng that had been natural air dried (LX-P) and vacuum freeze-dried (LX-L). Multivariate statistical analysis such as principal component analysis (PCA) and supervised orthogonal partial least squared discrimination analysis (OPLS-DA) were used to select the influential components of different samples...
April 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28462122/rg3-enriched-korean-red-ginseng-enhances-blood-pressure-stability-in-spontaneously-hypertensive-rats
#19
Harsha Nagar, Sujeong Choi, Saet-Byel Jung, Byeong Hwa Jeon, Cuk-Seong Kim
BACKGROUND: Korean Red Ginseng (Panax ginseng) has been shown to exert antihypertensive effects. In particular, ginsenoside Rg3 is thought to be a potent modulator of vascular function. The present study was performed to examine the antihypertensive efficacy of Korean Red Ginseng (KRG) extract and Rg3-enriched KRG (REKRG) extract. METHODS: Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) were divided into six groups (WKY control, WKY-KRG, WKY-REKRG, SHR control, SHR-KRG, and SHR-REKRG), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at the carotid artery, followed by injection of 3 mg/kg KRG or 3 mg/kg REKRG...
September 2016: Integr Med Res
https://www.readbyqxmd.com/read/28461003/ginsenoside-rg3-exerts-anti-depressive-effect-on-an-nmda-treated-cell-model-and-a-chronic-mild-stress-animal-model
#20
Hualin Zhang, Zhongliu Zhou, Ziming Chen, Zhiyong Zhong, Zhong Li
Depression is a common mental disorder and a leading cause of disability. At its most severe, it can lead to suicide. Recently, there has been growing interest in the application of natural herbs for the prevention and treatment of depression. In this report, we found that the ginsenoside active component Rg3 has an apparent antidepressant effect. In N-methyl-d-aspartic acid (NMDA)-treated HT22 murine hippocampal neuronal cells, Rg3 recovered proliferation and inhibited apoptosis by altering the cell cycle...
April 12, 2017: Journal of Pharmacological Sciences
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