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https://www.readbyqxmd.com/read/29331795/development-and-validation-of-an-uhplc-ms-ms-approach-for-simultaneous-quantification-of-five-bioactive-saponins-in-rat-plasma-application-to-a-comparative-pharmacokinetic-study-of-aqueous-extracts-of-raw-and-salt-processed-achyranthes-bidentata
#1
Yi Tao, Yingshan Du, Weidong Li, Baochang Cai
A simple, accurate and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry approach was established for the simultaneous determination of β-ecdysterone, 25S-inokosterone, ginsenoside Ro, chikusetsusaponin IV and chikusetsusaponin IVa in rat plasma after oral administration of raw and salt-processed Achyranthes bidentata extract. The saponins were completely separated on a Waters BEH C18 UHPLC column by using acetonitrile/0.1% formic acid-water as mobile phases. The mass analysis was performed in a triple quadrupole mass spectrometer using multiple reaction monitoring (MRM) with negative scan mode...
January 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29330486/new-generation-of-drug-delivery-systems-based-on-ginsenoside-rh2-lysine-and-arginine-treated-highly-porous-graphene-for-improving-anticancer-activity
#2
Hadi Zare-Zardini, Asghar Taheri-Kafrani, Ahmad Amiri, Abdol-Khalegh Bordbar
In this study, Rh2-treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene (Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2-treated Gr-Lys (Gr-Lys-Rh2) and Rh2-treated Gr-Arg (Gr-Arg-Rh2) were synthesized. MTT assay was used for evaluation of cytotoxicity of samples on ovarian cancer (OVCAR3), breast cancer (MDA-MB), Human melanoma (A375) and human mesenchymal stem cells (MSCs) cell lines. The percentage of apoptotic cells was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329879/mir-134-modulates-chronic-stress-induced-structural-plasticity-and-depression-like-behaviors-via-downregulation-of-limk1-cofilin-signaling-in-rats
#3
Cuiqin Fan, Xiuzhi Zhu, Qiqi Song, Peng Wang, Zhuxi Liu, Shu Yan Yu
Increasing evidence has suggested that depression is a neuropsychiatric condition associated with neuroplasticity within specific brain regions. However, the mechanisms by which neuroplasticity exerts its effects in depression remain largely uncharacterized. In the present study we show that chronic stress effectively induces depression-like behaviors in rats, an effect which was associated with structural changes in dendritic spines and synapse abnormalities within neurons of the ventromedial prefrontal cortex (vmPFC)...
January 9, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29329463/ginsenoside-rh1-a-systematic-review-of-its-pharmacological-properties
#4
Dao Ngoc Hien Tam, Duy Hieu Truong, Thi Thanh Hoa Nguyen, Le Nhat Quynh, Linh Tran, Hong Duong Nguyen, Bahaa Eldin Shamandy, Thi Minh Huong Le, Dang Khoa Tran, Dina Sayed, Van Vinh Vu, Shusaku Mizukami, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29329092/effect-of-aspirin-on-the-pharmacokinetics-and-absorption-of-panax-notoginseng-saponins
#5
Zhihao Tian, Huanhuan Pang, Qiang Zhang, Shouying Du, Yang Lu, Lin Zhang, Jie Bai, Pengyue Li, Danqi Li, Mengdi Zhao, Xiaonan Chen
BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R1, ginsenoside Rg1, Rb1, Re and Rd. in blood were simultaneously measured by UPLC/MS/MS...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29328420/ginsenoside-rg3-inhibits-keloid-fibroblast-proliferation-angiogenesis-and-collagen-synthesis-in-vitro-via-the-tgf%C3%A2-%C3%AE-smad-and-erk-signaling-pathways
#6
Mengyao Tang, Weiwei Bian, Liying Cheng, Lu Zhang, Rong Jin, Wenbo Wang, Yuguang Zhang
A wide range of therapeutic options exists for the treatment of keloids, all of which have their own strengths; however, a high risk of side‑effects and frequent recurrence remains. Therefore, the present study aimed to identify improved therapeutic approaches or drugs for the treatment of keloids. Ginsenoside Rg3 (Rg3) has been reported to exert numerous antitumor effects, thus indicating that Rg3 may be a potential therapeutic agent that targets keloids. The present study determined the effects of Rg3 on human keloid fibroblasts (KFs) in vitro, and further explored the associated molecular and cellular mechanisms...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29324976/ginsenoside-rg1-inhibits-apoptosis-by-increasing-autophagy-via-the-ampk-mtor-signaling-in-serum-deprivation-macrophages
#7
Ping Yang, Lu Ling, Wenjing Sun, Junquan Yang, Ling Zhang, Guoji Chang, Jiazhi Guo, Jun Sun, Lin Sun, Di Lu
Ginsenoside Rg1 (Rg1) has been widely used in a broad range of cardiovascular and cerebral-vascular diseases because of its unique therapeutic properties. However, the underlying mechanisms of Rg1 in the treatment of atherosclerosis have not been fully explored. This study sought to determine the precise molecular mechanisms on how Rg1 might be involved in regulating apoptosis in serum deprivation-induced Raw264.7 macrophages and primary bone marrow-derived macrophages. Results demonstrated that Rg1 treatment effectively suppressed apoptosis and the expression of phosphorylation level of mTOR induced by serum deprivation in Raw264...
January 9, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29324789/an-l213a-variant-of-%C3%AE-glycosidase-from-sulfolobus-solfataricus-with-increased-%C3%AE-l-arabinofuranosidase-activity-converts-ginsenoside-rc-to-compound-k
#8
Ji-Hyeon Choi, Kyung-Chul Shin, Deok-Kun Oh
Compound K (C-K) is a crucial pharmaceutical and cosmetic component because of disease prevention and skin anti-aging effects. For industrial application of this active compound, the protopanaxadiol (PPD)-type ginsenosides should be transformed to C-K. β-Glycosidase from Sulfolobus solfataricus has been reported as an efficient C-K-producing enzyme, using glycosylated PPD-type ginsenosides as substrates. β-Glycosidase from S. solfataricus can hydrolyze β-d-glucopyranoside in ginsenosides Rc, C-Mc1, and C-Mc, but not α-l-arabinofuranoside in these ginsenosides...
2018: PloS One
https://www.readbyqxmd.com/read/29316736/ginsenoside-rb2and-20-s-ginsenoside-rg3-from-koreanred-ginseng-prevent-rotavirus-infection-in-newborn-mice
#9
Hui Yang, Kwang-Hoon Oh, Hyun Jin Kim, Young Ho Cho, Yung Choon Yoo
It is well known that Korean red ginseng has various biological activities. However, there is little knowledge about antiviral activity of Korean red ginseng and its ginsenosides. In this study, we addressed whether oral administration of ginsenoside-Rb2 and -Rg3 were able to protect against rotavirus (RV) infection. Protective effect of ginsenosides against RV infection was examined using an in vivo experiment model in which newborn mice (10-day-old) were inoculated perorally (p.o.) with 1.5X106 plaque-forming units (PFU)/mouse of RV strain SA11...
January 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29307726/ginsenoside-rg1-protects-rat-bone-marrow-mesenchymal-stem-cells-against-ischemia-induced-apoptosis-through-mir-494-3p-and-rock-1
#10
Hui-Zhen Zheng, Xue-Kun Fu, Jiu-Long Shang, Rong-Xi Lu, Yong-Fang Ou, Chun-Ling Chen
This study aimed to verify the cytoprotective effect of ginsenoside Rg1 in vivo, and to elucidate the mechanism of Rg1 in the ischemic microenvironment. Male rat bone marrow mesenchymal stem cells (rBMSCs) or rBMSCs treated with Rg1 were injected into ischemic region of the arterial embolism hind limb in female rats. Behavioral and histological data, obtained one-week post injection, showed that rBMSCs with Rg1 could improve the survival rate of BMSCs and enhance the therapeutic effects. rBMSCs treated with hypoxia and serum deprivation for 24h (H/SD-rBMSCs) showed the up-regulated expression of ras homolog family member A (RhoA), Rho associated coiled-coil containing protein kinase 1 (ROCK-1), myosin light chain 2 (MLC-2), Bcl2 associated agonist of cell death (Bad) and Bcl2 associated X, apoptosis regulator (Bax); while the expression of miR-148b-3p, miR-148b-5p and miR-494-3p was down-regulated...
January 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29306188/ginsenosides-and-ginsenosidases-in-the-pathobiology-of-ginseng-cylindrocarpon-destructans-zinss-scholten
#11
Jiao Wang, Honglei Chen, Juan Gao, Jixun Guo, Xuesong Zhao, Yifa Zhou
To investigate the role that ginsenosides (and some of their metabolites) play in interactions between plants and phytopathogenic fungi (e.g. Cylindrocarpon destructans (Zinss) Scholten), we systematically determined the anti-fungal activities of six major ginsenosides (Rb1, Rb2, Rc, Rd, Re and Rg1), along with the metabolites of ginsenoside Rb1 (Gypenoside XVII (G-XVII) and F2), against the ginseng root pathogen C. destructans (Zinss) Scholten and non-ginseng pathogens Fusarium graminearum Schw., Exserohilum turcicum (Pass...
December 29, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29302971/metabonomics-approach-to-comparing-the-anti-stress-effects-of-four-panax-ginseng-components-in-rats
#12
Jingcheng Wang, Yuanlong Hou, Zhiying Jia, Xie Xie, Jiajian Liu, Yani Kang, Xin Wang, Xiaoyan Wang, Wei Jia
Different components of P. ginseng have different properties and medicinal effects. Metabonomics was a perspective approach to analyze global endogenous metabolites response to physiological and pathological processe. In this study, untargeted -metabonomics method using GC/TOFMS combined with multivariate statistical techniques was applied to compare entire metabolite differences and the anti-stress variations among four components of P. ginseng, total ginsenosides (TG), panaxadiol (PD), panaxatriol (PT) and ginseng polysaccharide (PS), in Sprague Dawley rats...
January 5, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29298510/structural-activity-relationship-of-ginsenosides-from-steamed-ginseng-in-the-treatment-of-erectile-dysfunction
#13
Ang Ying, Qing-Tao Yu, Li Guo, Wen-Song Zhang, Jin-Feng Liu, Yun Li, Hong Song, Ping Li, Lian-Wen Qi, Ya-Zhong Ge, E-Hu Liu, Qun Liu
Ginseng has been reported to have diverse pharmacological effects. One of the therapeutic claims for ginseng is to enhance sexual function. Ginsenosides are considered as the major active constituents. A steaming process can alter the ginsenoside profile of ginseng products. The structure-function relationship of ginsenosides in the treatment of erectile dysfunction (ED) has not been investigated yet. In this work, 15 different processed ginsengs are produced by steaming, and 13 major ginsensosides are quantified by liquid chromatography with UV detection, including Rg1, Re, Rf, Rb1, Rc, Rb2, Rf, Rk3, Rh4, 20S-Rg3, 20R-Rg3, Rk1, and Rg5...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29297848/ciceribacter-azotifigens-sp-nov-a-nitrogen-fixing-bacterium-isolated-from-activated-sludge
#14
Muhammad Zubair Siddiqi, Gyu-Min Choi, Wan-Taek Im
A Gram-reaction-negative, catalase- and oxidase-positive, aerobic, transparent, motile and rod-shaped bacterium that was capable of fixing dinitrogen (designated strain A.slu09T), isolated from activated sludge, was characterized by a polyphasic approach to clarify its taxonomic position. Strain A.slu09T was observed to grow optimally at 30 °C and at pH 7.0 on R2A agar medium. Strain A.slu09T showed β-glucosidase activity, converting the major ginsenoside Rd to ginsenoside F2. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain A...
January 3, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29280337/analysis-of-bioactive-components-and-multi-component-pharmacokinetics-of-saponins-from-leaves-of-panax-notoginseng-in-rat-plasma-after-oral-administration-by-lc-ms-ms
#15
Zhengcai Ju, Jia Li, Han Han, Li Yang, Zhengtao Wang
In this study, simple ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass tandem mass spectrometry was used to characterize the absorbed components in rat plasma after the oral administration of saponins from leaves of Panax notoginseng. Seventeen prototype compounds were structurally characterized. Furthermore, a simple and sensitive liquid chromatography with tandem mass spectrometry method was also used for the simultaneous determination of notoginsenoside Fc, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rb3, ginsenoside Rd and notoginsenoside Fe in rat plasma within 5 min...
December 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29247225/ginsenoside-rg3-decreases-fibrotic-and-invasive-nature-of-endometriosis-by-modulating-mirna-27b-in-vitro-and-in-vivo-studies
#16
Min Kyoung Kim, Seung Kyun Lee, Ji Hyun Park, Jae Hoon Lee, Bo Hyon Yun, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi
This research aimed to evaluate the potential therapeutic effects of Rg3 on endometriosis and identify target miRNAs. We designed an in vitro study using human endometrial stromal cells (HESCs) obtained from patients with endometriosis and an in vivo study using mouse models. HESCs were treated with Rg3-enhanced red ginseng extract (Rg3E); real-time PCR and microarray profiling, transfection, and western blot were performed. Mouse endometriosis models were developed and supplemented with Rg3E for 8 weeks. Gross lesion size and fibrotic character were analyzed in the mouse models...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29245089/metabolic-analysis-of-panax-notoginseng-saponins-with-gut-microbiota-mediated-biotransformation-by-hplc-dad-q-tof-ms-ms
#17
Man-Yun Chen, Li Shao, Wei Zhang, Chong-Zhi Wang, Hong-Hao Zhou, Wei-Hua Huang, Chun-Su Yuan
Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that are potential bioactive substances. In this study, we aimed to characterize the metabolic profiles of P. notoginseng saponins (PNS) by incubating them with human gut microbiota. The notoginsenosides, ginsenosides and related metabolites were separated and identified using a highly sensitive and selective high-performance liquid chromatography coupled with diode array detection/quadrupole tandem time-of-flight mass spectrometry (HPLC-DAD-Q-TOF-MS/MS)...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29243439/-identification-of-saponins-from-panax-notoginseng-in-metabolites-of-rats
#18
Wen-Wen Shen, Yin Zhang, Shou-Bei Qiu, Fen-Xia Zhu, Xiao-Bin Jia, Dao-Quan Tang, Bin Chen
UPLC-QTOF-MS/MS was used to identify metabolites in rat blood, urine and feces after the administration of n-butanol extract derived from steamed notoginseng. The metabolic process of saponins came from steamed notoginseng was analyzed. The metabolites were processed by PeakView software, and identified according to the structural characteristics of prototype compounds and the accurate qualitative and quantitative changes of common metabolic pathways. Four saponins metabolites were identified based on MS/MS information of metabolites, namely ginsenoside Rh₄, Rk₃, Rk₁, Rg₅,and their 15 metabolites were verified...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29242997/synergistic-production-of-20-s-protopanaxadiol-from-protopanaxadiol-type-ginsenosides-by-%C3%AE-glycosidases-from-dictyoglomus-turgidum-and-caldicellulosiruptor-bescii
#19
Ji-Hyeon Choi, Min-Ju Seo, Kyung-Chul Shin, Ki Won Lee, Deok-Kun Oh
20(S)-Protopanaxadiol (APPD) has potential uses in the pharmaceutical, cosmetic, and food industries because of its anti-stress, anti-fatigue, anti-cancer, anti-inflammatory, and anti-wrinkle properties. However, APPD production is difficult because β-glycosidases that convert the protopanaxadiol (PPD)-type ginsenoside compound K to APPD are rare. β-Glycosidase from Dictyoglomus turgidum (DT-bgl) has the highest specific activity for converting compound K to APPD, but exhibits no activity towards the α-L-arabinopyranoside moiety in compound Y...
December 14, 2017: AMB Express
https://www.readbyqxmd.com/read/29241654/ginsenoside-rb1-confers-neuroprotection-via-promotion-of-glutamate-transporters-in-a-mouse-model-of-parkinson-s-disease
#20
Yun-Long Zhang, Yan Liu, Xin-Pan Kang, Chun-Yan Dou, Ren-Gong Zhuo, Shu-Qiong Huang, Li Peng, Lei Wen
Ginsenoside Rb1 has been demonstrated to protect dopaminergic (DA) neurons from death in vitro. However, the neuroprotective effects and underlying mechanism of Rb1 in treating Parkinson's disease (PD) remain uncharacterized. In this study, we explored the effects of Rb1 on the movement disorder and the underlying mechanisms based on the glutamatergic transmission and excitotoxicity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Here, for the first time, we report that Rb1 treatment ameliorates motor deficits, prevents DA neuron death, and suppresses α-synuclein expression and astrogliosis in the MPTP mouse model of PD...
December 12, 2017: Neuropharmacology
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