Maria Hellena Garcia Novais, Naiza Saraiva Farias, Andressa Guilhermino Dos Santos, Victor Juno Alencar Fonseca, Jaime Ribeiro-Filho, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga
The present article aims to evaluate the antifungal and antivirulence effect of the phytoconstituent Limonene against Candida spp. Antifungal assays were performed, where the concentration capable of inhibiting 50% of fungal growth, the growth inhibition curve, the minimum fungicidal concentration, the evaluation of the modifying effect with fluconazole, the inhibitory effect of the substances on the morphological transition of Candida spp. and the statistical analysis of the results were determined. With this study, it was seen that limonene demonstrated growth inhibition for the strains tested and when associated the natural compound with Fluconazole, there was potentiation of the effect of the drug, since the inhibition of growth by the combination occurred at lower concentrations against all strains tested, when compared to the drug alone, which inhibited growth at the highest concentration...
March 1, 2024: Acta Tropica