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Vlad M Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur
Introduction: The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae...
2018: Journal of Immunology Research
Yiqun Zhang, Wei Yu, Zhaoyu Ba, Shusen Cui, Jie Wei, Hong Li
Background: Due to the increasing number of patients with bone defects, bone nonunion and osteo-myelitis, tumor and congenital diseases, bone repair has become an urgent problem to be solved. Methods: In this study, the 3D-printed scaffolds of ternary composites containing mesoporous bioglass fibers of magnesium calcium silicate (mMCS), gliadin (GA) and polycaprolactone (PCL) were fabricated using a 3D Bioprinter. Results: The compressive strength and in vitro degradability of the mMCS/GA/PCL composites (MGPC) scaffolds were improved with the increase of mMCS content...
2018: International Journal of Nanomedicine
Jae-Hyun Jung, Soo-Byung Park, Kyung-Hyeon Yoo, Seog-Young Yoon, Moon-Kyoung Bae, Dong Joon Lee, Ching-Chang Ko, Yong Hoon Kwon, Yong-Il Kim
OBJECTIVES: To synthesize two different sizes of bioactive glass-coated mesoporous silica nanoparticles (BGN@MSNs) and to investigate their effects on dentinal tubule occlusion and remineralization. MATERIALS AND METHODS: Two different sizes of mesoporous silica nanoparticles (MSNs) were synthesized using the Stöber method (368A, 1840A) and coated with bioactive glass nanoparticles (BGNs) using a modified quick alkali-mediated sol-gel method (368B, 1840B). Sensitive tooth disc models were prepared and divided into six groups and the following treatments were applied: group 1-no treatment, group 2-bioglass, group 3-368A, group 4-368B, group 5-1840A, and group 6-1840B...
September 30, 2018: Clinical Oral Investigations
Pawan Kumar, Brijnandan S. Dehiya, Anil Sindhu
Background: This study addressed the development of biodegradable and biocompatible scaffolds with enhanced biomechanical characteristics. The biocompatibility and the cationic nature of chitosan (CTS) make it more effective as a bone grafting material. Methods: The hydroxyapatite nanoparticles (nHA) were synthesized by hydrothermal method, and bioglass (nBG) (50% SiO2-45% CaO-5% P2O5) was synthesized using sol-gel method. The ibuprofen-loaded CTS/nHA and CTS/nBG scaffolds were fabricated by using freeze-drying method...
September 29, 2018: Iranian Biomedical Journal
B N Singh, K Pramanik
The development of bone tissue construct through tissue engineering approach offers a great promise in meeting the increasing demand for repair and regeneration of damaged and/or diseased bone tissue. For the generation of bone tissue engineered construct, polymer-ceramic composite matrices with nanostructure architecture and mesenchymal stem cells (hMSCs) of human origin are of prime requirement. Keeping these in view, in the present work a novel electrospun nanofibrous silk fibroin (SF)/carboxymethyl cellulose (CMC)/nano-bioglass (nBG) composite scaffold that mimics native bone extracellular matrix with appropriate composition was designed and fabricated by free liquid surface electrospinning technique...
September 13, 2018: Journal of Biomaterials Science. Polymer Edition
Vincenzo Farano, Jean-Christophe Maurin, Nina Attik, Phil Jackson, Brigitte Grosgogeat, Kerstin Gritsch
Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
B Aksakal, M Demirel
Selenium (Se)- and Silver (Ag)-doped Bioglass® -based biografts were synthesized using the sol-gel method. Fourier-transform infrared spectroscopy, inductively coupled plasma mass spectrometry, scanning electron microscopy and energy-dispersive X-ray analyses were carried out in order to examine mechanostructure of synthesized bioglass-based bioceramics. The effects of Se and Ag additions on cell viability were investigated via cytotoxicity and antibacterial activity analysis, respectively. The bacteria of Escherichia coli ( E...
October 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Nicholas H Cohrs, Konstantin Schulz-Schönhagen, Dirk Mohn, Petra Wolint, Gabriella Meier Bürgisser, Wendelin J Stark, Johanna Buschmann
Silicone is an important material family used for various medical implants. It is biocompatible, but its bioinertness prevents cell attachment, and thus tissue biointegration of silicone implants. This often results in constrictive fibrosis and implant failure. Bioglass 45S5® (BG) could be a suitable material to alter the properties of silicone, render it bioactive and improve tissue integration. Therefore, BG micro- or nanoparticles were blended into medical-grade silicone and 2D as well as 3D structures of the resulting composites were analyzed in ovo by a chick chorioallantoic membrane (CAM) assay...
September 6, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Lucas Souza, João Henrique Lopes, Davi Encarnação, Italo Odone Mazali, Richard Alan Martin, José Angelo Camilli, Celso Aparecido Bertran
The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical reactivity and the bioactivity of Nb-substituted glass in simulated body fluid (SBF) by 31 P MASNMR spectroscopy, (ii) determination of ionic leaching profiles in buffered solution by inductively coupled plasma optical emission spectrometry (ICP-OES), and (iii) assessment of the compatibility and osteogenic differentiation of human embryonic stem cells (hESCs) treated with dissolution products of different compositions of Nb-substituted glass...
August 24, 2018: Scientific Reports
Meng He, Xiaoyi Chen, Kui Cheng, Lingqing Dong, Wenjian Weng, Huiming Wang
Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2 /Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2 /Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2 /BG)...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Lingzhi Kong, Zhi Wu, Huakun Zhao, Haomin Cui, Ji Shen, Jiang Chang, Haiyan Li, Yaohua He
Diabetic wound is hard to heal mainly because of the difficulty in vascularization in the wound area. Accumulating results have shown that desferrioxamine (DFO) can promote secretion of hypoxia inducible factor-1 (HIF-1α), thereby upregulating the expression of angiogenic growth factors and facilitating revascularization. Our preliminary study has demonstrated that Si ions in bioglass (BG) can upregulate vascular endothelial growth factor (VEGF) expression, thus promoting revascularization. It is hypothesized that the combined use of BG and DFO may have a synergistic effect in promoting VEGF expression and revascularization...
September 12, 2018: ACS Applied Materials & Interfaces
Olinto Santos Cardoso, Meire Coelho Ferreira, Edilausson Moreno Carvalho, Paulo Vitor Campos Ferreira, José Bauer, Ceci Nunes Carvalho
Introduction: The use of bioactive glasses to re-establish or increase mechanical properties of the root dentin may be an interesting alternative. The aim of this study was to evaluate the effect of root repair materials and bioactive glasses on the microhardness of human root dentin. Methods and Materials: Sixty-four sectioned palatal roots of human molars were prepared and two slices were obtained of the middle third of each root (one corresponding to the control group, without treatment, and the other to the experimental group)...
2018: Iranian Endodontic Journal
Basam A E Ben-Arfa, Isabel M Miranda Salvado, José M F Ferreira, Robert C Pullar
Novel quaternary (67Si-24Ca-10Na-8P) glass powders were successfully synthesised by sol-gel followed by two alternative drying schedules, conventional drying (CD) and an innovative fast drying (FD) process (200 times quicker). The glasses were thermally stabilised at 550 °C, and then characterised by different complementary techniques. The samples showed very similar silica network structures, with the FD one having slightly lower degree of polymerisation than the CD sample. This less polymerised, more open, network structure exhibited an improved bioactivity in simulated body fluid (SBF), probably also due to the apparent presence of poorly crystalline HAp in the stabilised glass powder...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Amirhossein Moghanian, Sadegh Firoozi, Mohammadreza Tahriri, Arman Sedghi
Lithium and strontium up to 10 mol% have been substituted for calcium in 58S bioactive glasses in order to enhance specific biological properties such as proliferation, alkaline phosphatase (ALP) activity of cells as well as antibacterial activity. In-vitro formation of hydroxyapatite was studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), inductively coupled plasma atomic emission spectrometry (ICP-AES) and scanning electron microscopy (SEM). Substitution of either Li or Sr for Ca in the composition had a retarding effect on the bioactivity while Li decreased and Sr increased the rate of ion release in the simulated body fluid solution...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Zhaoyu Ba, Zhaoxiong Chen, Yufeng Huang, Du Feng, Qinghui Zhao, Jianguang Zhu, Desheng Wu
Introduction: It is predicted that with increased life expectancy in the whole world, there will be a greater demand for synthetic biomedical materials to repair or regenerate lost, injured or diseased tissues. Natural polymers, as biomedical materials, have been widely applied in the field of regenerative medicine. Materials and methods: By incorporation of nanoporous diopside bioglass (nDPB) into glia-din (GL) matrix, macro-nanoporous scaffolds of nDPB/GL composites (DGC) were fabricated by method of solution compressing and particles leaching...
2018: International Journal of Nanomedicine
Swati Midha, Sumit Kumar, Aarushi Sharma, Kulwinder Kaur, Xiaomeng Shi, Parichart Naruphontjirakul, Julian R Jones, Sourabh Ghosh
A major challenge in Bone tissue engineering is to develop patient-specific, defect-site specific grafts capable of triggering specific cell signaling pathways. We could programmably fabricate the 3D printed bone constructs via direct ink writing of silk-gelatin-bioactive glass (SF-G-BG) hybrids using two different compositions of melt-derived bioactive glasses (with and without strontium) and compared against commercial 45S5 Bioglass®. Physico-chemical characterization revealed that released ions from bioactive glasses inhibited the conformational change of Bombyx mori silk fibroin protein (from random coil to β-sheet conformation), affecting printability of the SF-G-BG ink...
July 11, 2018: Biomedical Materials
Seyed Mohammad Ahmadi, Aliasghar Behnamghader, Azadeh Asefnejaad
BACKGROUND: Bioactive glasses with different compositions have been extensively used as bone tissue engineering. Preparation, development and characterization of alginate pastes containing bioglass for bone repair applications were the purpose of this study. OBJECTIVE: The injectable bone pastes were produced from sol-gel derived bioactive glass nanoparticles with various CaO/P2O5 ratios of 19, 9.5 and 4.75 and sodium alginate solutions with different concentrations of 1, 2 and 4 wt...
July 3, 2018: Current Stem Cell Research & Therapy
Faezeh Azizi, Hamidreza Jalil, Zohreh Nasiri, Jamal Moshtaghian, Fariba Esmaeili, Ali Doostmohammadi, Leila Shabani, Esmaeil Ebrahimie
Tissue engineering, as a novel transplantation therapy, aims to create biomaterial scaffolds resembling the extracellular matrix in order to regenerate the damaged tissues. Adding bioactive factors to the scaffold would improve cell-tissue interactions. In this study, the effect of chitosan polyvinyl alcohol nanofibres containing carbon nanotube scaffold with or without active bioglass (BG+ /BG- ), in combination with neonatal rat brain extract on cell viability, proliferation, and neural differentiation of P19 embryonic carcinoma stem cells was investigated...
June 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
Yanling Zhou, Long Gao, Jinliang Peng, Min Xing, Yan Han, Xiaoya Wang, Yuhong Xu, Jiang Chang
In this study, a novel Bioglass/albumin composite hydrogel with controllable injectability, good adhesiveness, and bioactivity, is developed by utilizing dual-functional bioactive ions released from Bioglass, which on one side controls the gelling time by creating an alkaline environment to regulate the cross-linking reaction between human serum albumin and succinimidyl succinate modified poly(ethylene glycol), and on the other side stimulates wound healing. The composite hydrogel exhibits adhesive property that is superior to clinically used fibrin and cyanoacrylate glues...
August 2018: Advanced Healthcare Materials
D Durgalakshmi, R Ajay Rakkesh, M Kesavan, S Ganapathy, T G Ajithkumar, S Karthikeyan, S Balakumar
In the present work, a crystallization-induced strontium-bioactive material, with a composition similar to Bioglass 45S5 system, was obtained using a sol-gel-assisted microwave method with nanorod morphologies of 30-80 nm in size. The effect of crystallization induced in the glass network, and its influence on the bioactivity and mechanical properties of bone and dentin regeneration, were the main novel findings of this work. Rietveld analysis of X-ray diffraction spectra showed the best fit with sodium (combeite, Na2Ca2Si3O9) and calcium (clinophosinaite, Ca2Na6O14P2Si2; calcium strontium silicate, Ca1...
June 25, 2018: Biomaterials Science
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