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Kartikeya Dixit, Niraj Sinha
45S5 Bioglass® has been used quite extensively in the form of particulate as synthetic bone graft. However, 45S5 glass has certain limitations such as difficulty in sintering and slow and partial conversion to hydroxy carbonated apatite. In pursuit of overcoming these limitations, bioactive glasses (13-93B1) containing increased amount of B₂O₃ by partial replacement of SiO₂ have been prepared using sol-gel technique in this study. Since bioactive glasses are brittle in nature, therefore, they are unsuitable for load bearing sites...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Ioana Lese, David Alexander Graf, Catherine Tsai, Adriano Taddeo, Martin Tobias Matter, Mihai A Constantinescu, Inge Katrin Herrmann, Radu Olariu
BACKGROUND: Distal flap necrosis is a frequent complication of perforator flaps. Advances in nanotechnology offer exciting new therapeutic approaches. Anti-inflammatory and neo-angiogenic properties of certain metal oxides within the nanoparticles, including bioglass and ceria, may promote flap survival. Here, we explore the ability of various nanoparticle formulations to increase flap survival in a rat model. MATERIALS AND METHODS: A 9 x 3 cm dorsal flap based on the posterior thigh perforator was raised in 32 Lewis rats...
2018: PloS One
Manz Andrea Stefanie, Attin Thomas, Sener Beatrice, Sahrmann Philipp
BACKGROUND: Dentine hypersensitivity is especially frequent in patients with pronounced periodontal attachment loss. Aim of the treatment is an obstruction of the dentine tubules in order to inhibit liquid or osmotic motion, which is considered as trigger for pain sensations. Novel approaches aim for obstruction by calcium phosphate compounds in order to rely on biocompatible compounds. It was the aim of the study to optically investigate the morphology and to assess the fluid permeability of treated dentine surfaces...
November 21, 2018: BMC Oral Health
A Sleibi, A Tappuni, D Mills, G R Davis, A Baysan
OBJECTIVES: The objective of this in vitro study was to quantify the amount of mineral change in demineralized dentin at pH 5.5 after the application of dental varnishes containing fluoride with casein phosphopeptide-amorphous calcium phosphate, fluoride and bioglass, or fluoride alone. METHODS AND MATERIALS: A total of 12 extracted human sound mandibular premolar root samples were coated with an acid-resistant varnish, leaving a 2 × 3 mm window at the outer root surface...
November 2018: Operative Dentistry
Yanlun Zhu, Lingzhi Kong, Fatemeh Farhadi, Wei Xia, Jiang Chang, Yaohua He, Haiyan Li
Osteochondral regeneration with the formation of hyaline cartilage and subchondral bone as well as the integration between the newly formed tissues with the host tissue still remains a great challenge. In this study, a construct containing an injectable continuous stratified scaffold and multiple cell systems was designed for enhancing osteochondral regeneration. Briefly, an injectable sodium alginate(SA)/bioglass (BG) composite hydrogel containing bone marrow stem cells (BMSCs) (SA/BG + BMSCs) was used for subchondral bone regeneration and an injectable thermosensitive SA/agarose (AG) composite hydrogel with co-culture of BMSCs and articular chondrocytes (ACs) (SA/AG + ACs/BMSCs) was applied for articular cartilage regeneration...
November 13, 2018: Biomaterials
P R Gabbai-Armelin, H W Kido, M A Cruz, J P S Prado, I R Avanzi, M R Custódio, A C M Renno, R N Granito
Bone fractures characterize an important event in the medical healthcare, being related to traumas, aging, and diseases. In critical conditions, such as extensive bone loss and osteoporosis, the tissue restoration may be compromised and culminate in a non-union consolidation. In this context, the osteogenic properties of biomaterials with a natural origin have gained prominence. Particularly, marine sponges are promising organisms that can be exploited as biomaterials for bone grafts. Thus, the objectives of this study were to study the physicochemical and morphological properties of biosilica (BS) from sponges by using scanning electron microscopy, Fourier-transform infrared, X-ray diffraction (SEM, FTIR and XRD respectively), mineralization, and pH...
November 16, 2018: Marine Biotechnology
Himanshu Tripathi, Chandana Rath, Arepalli Sampath Kumar, Partha Pratim Manna, S P Singh
Strontium based bioactive glasses have shown a better biocompatibility than calcia based bioactive glasses. In this report, we have shown that the bioactivity is found to be even more when we incorporate Al2 O3 upto 1.5 mol% in SiO2 -CaO-P2 O5 -SrO bioactive glass. We have studied the structural, physico-mechanical and bioactive properties in these glasses with varying alumina concentration from 0.5 to 2.5 mol%. The bioactivity of the glasses is evaluated by in vitro test in simulated body fluid (SBF). The formation of hydroxy carbonated apatite layer (HCA) on the surface of glasses after immersion in SBF is identified by the XRD, FTIR and SEM...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
A C Vale, P R Pereira, A M Barbosa, E Torrado, N M Alves
Bioglass nanoparticles (BGs) are of outmost importance in the biomedical field, because their unique characteristics, namely osteoconductivity and osteoinductivity, and also in certain conditions, angiogenic and bactericidal properties. In this work, novel bioglass nanoparticles containing silver (AgBGs) were synthesized by a sol-gel method, adopting different thermal treatments to obtain new nanoparticles with bioactive and antibacterial features. This is the first systematic study of the effect of the thermal treatment on the properties of AgBGs...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
Yu-Wei Ge, Jia-Wei Lu, Zhen-Yu Sun, Zhi-Qing Liu, Jun Zhou, Qin-Fei Ke, Yuan-Qing Mao, Ya-Ping Guo, Zhen-An Zhu
Bioglass scaffolds have great application potentials in orthopedics, and Ursolic acid (UA) can effectively promote in vivo new bone formation. Herein, we for the first time developed the mesoporous bioglass/chitosan porous scaffolds loaded with UA (MBG/CS/UA) for enhanced bone regeneration. The MBG microspheres with particle sizes of ~300 nm and pore sizes of ~3.9 nm were uniformly dispersed on the CS films. The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances...
November 9, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Devis Bellucci, Valeria Cannillo, Alexandre Anesi, Roberta Salvatori, Luigi Chiarini, Tiziano Manfredini, Davide Zaffe
In this work, a set of novel bioactive glasses have been tested in vivo in an animal model. The new compositions, characterized by an exceptional thermal stability and high in vitro bioactivity, contain strontium and/or magnesium, whose biological benefits are well documented in the literature. To simulate a long-term implant and to study the effect of the complete dissolution of glasses, samples were implanted in the mid-shaft of rabbits' femur and analyzed 60 days after the surgery; such samples were in undersized powder form...
November 8, 2018: Materials
Fatemeh Soltaninejad, Azam Valian, Maryam Moezizadeh, Mahdieh Khatiri, Hossein Razaghi, Hanieh Nojehdehian
PURPOSE: To evaluate the morphological properties, phase transformation, and microshear bond strength of composite cement to bioglass-coated zirconia surfaces treated with Nd:YAG laser. MATERIALS AND METHODS: Seventy-five zirconia disks were divided into five groups (n = 15). Group C received no surface treatment (control). Group S was subjected to sandblasting with 50-μm aluminum oxide particles. Group B samples were coated with bioglass 45S5. Groups BL9 and BL5 received bioglass coating and laser irradiation with 9 J/cm2 and 5 J/cm2 energy density...
October 19, 2018: Journal of Adhesive Dentistry
Vlad M Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur
Introduction: The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae...
2018: Journal of Immunology Research
Yiqun Zhang, Wei Yu, Zhaoyu Ba, Shusen Cui, Jie Wei, Hong Li
Background: Due to the increasing number of patients with bone defects, bone nonunion and osteo-myelitis, tumor and congenital diseases, bone repair has become an urgent problem to be solved. Methods: In this study, the 3D-printed scaffolds of ternary composites containing mesoporous bioglass fibers of magnesium calcium silicate (mMCS), gliadin (GA) and polycaprolactone (PCL) were fabricated using a 3D Bioprinter. Results: The compressive strength and in vitro degradability of the mMCS/GA/PCL composites (MGPC) scaffolds were improved with the increase of mMCS content...
2018: International Journal of Nanomedicine
Jae-Hyun Jung, Soo-Byung Park, Kyung-Hyeon Yoo, Seog-Young Yoon, Moon-Kyoung Bae, Dong Joon Lee, Ching-Chang Ko, Yong Hoon Kwon, Yong-Il Kim
OBJECTIVES: To synthesize two different sizes of bioactive glass-coated mesoporous silica nanoparticles (BGN@MSNs) and to investigate their effects on dentinal tubule occlusion and remineralization. MATERIALS AND METHODS: Two different sizes of mesoporous silica nanoparticles (MSNs) were synthesized using the Stöber method (368A, 1840A) and coated with bioactive glass nanoparticles (BGNs) using a modified quick alkali-mediated sol-gel method (368B, 1840B). Sensitive tooth disc models were prepared and divided into six groups and the following treatments were applied: group 1-no treatment, group 2-bioglass, group 3-368A, group 4-368B, group 5-1840A, and group 6-1840B...
September 30, 2018: Clinical Oral Investigations
Pawan Kumar, Brijnandan S. Dehiya, Anil Sindhu
Background: This study addressed the development of biodegradable and biocompatible scaffolds with enhanced biomechanical characteristics. The biocompatibility and the cationic nature of chitosan (CTS) make it more effective as a bone grafting material. Methods: The hydroxyapatite nanoparticles (nHA) were synthesized by hydrothermal method, and bioglass (nBG) (50% SiO2-45% CaO-5% P2O5) was synthesized using sol-gel method. The ibuprofen-loaded CTS/nHA and CTS/nBG scaffolds were fabricated by using freeze-drying method...
September 29, 2018: Iranian Biomedical Journal
B N Singh, K Pramanik
The development of bone tissue construct through tissue engineering approach offers a great promise in meeting the increasing demand for repair and regeneration of damaged and/or diseased bone tissue. For the generation of bone tissue engineered construct, polymer-ceramic composite matrices with nanostructure architecture and mesenchymal stem cells (hMSCs) of human origin are of prime requirement. Keeping these in view, in the present work a novel electrospun nanofibrous silk fibroin (SF)/carboxymethyl cellulose (CMC)/nano-bioglass (nBG) composite scaffold that mimics native bone extracellular matrix with appropriate composition was designed and fabricated by free liquid surface electrospinning technique...
October 29, 2018: Journal of Biomaterials Science. Polymer Edition
Vincenzo Farano, Jean-Christophe Maurin, Nina Attik, Phil Jackson, Brigitte Grosgogeat, Kerstin Gritsch
Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
B Aksakal, M Demirel
Selenium (Se)- and Silver (Ag)-doped Bioglass® -based biografts were synthesized using the sol-gel method. Fourier-transform infrared spectroscopy, inductively coupled plasma mass spectrometry, scanning electron microscopy and energy-dispersive X-ray analyses were carried out in order to examine mechanostructure of synthesized bioglass-based bioceramics. The effects of Se and Ag additions on cell viability were investigated via cytotoxicity and antibacterial activity analysis, respectively. The bacteria of Escherichia coli ( E...
October 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Nicholas H Cohrs, Konstantin Schulz-Schönhagen, Dirk Mohn, Petra Wolint, Gabriella Meier Bürgisser, Wendelin J Stark, Johanna Buschmann
Silicone is an important material family used for various medical implants. It is biocompatible, but its bioinertness prevents cell attachment, and thus tissue biointegration of silicone implants. This often results in constrictive fibrosis and implant failure. Bioglass 45S5® (BG) could be a suitable material to alter the properties of silicone, render it bioactive and improve tissue integration. Therefore, BG micro- or nanoparticles were blended into medical-grade silicone and 2D as well as 3D structures of the resulting composites were analyzed in ovo by a chick chorioallantoic membrane (CAM) assay...
September 6, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Lucas Souza, João Henrique Lopes, Davi Encarnação, Italo Odone Mazali, Richard Alan Martin, José Angelo Camilli, Celso Aparecido Bertran
The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical reactivity and the bioactivity of Nb-substituted glass in simulated body fluid (SBF) by 31 P MASNMR spectroscopy, (ii) determination of ionic leaching profiles in buffered solution by inductively coupled plasma optical emission spectrometry (ICP-OES), and (iii) assessment of the compatibility and osteogenic differentiation of human embryonic stem cells (hESCs) treated with dissolution products of different compositions of Nb-substituted glass...
August 24, 2018: Scientific Reports
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