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https://www.readbyqxmd.com/read/30073560/changes-in-feeding-habits-promoted-the-differentiation-of-the-composition-and-function-of-gut-microbiotas-between-domestic-dogs-canis-lupus-familiaris-and-gray-wolves-canis-lupus
#1
Tianshu Lyu, Guangshuai Liu, Huanxin Zhang, Lidong Wang, Shengyang Zhou, Huashan Dou, Bo Pang, Weilai Sha, Honghai Zhang
Wolves (Canis lupus) and their domesticated and close relatives, dogs (Canis lupus familiaris), have great differences in their diets and living environments. To the best of our knowledge, the fundamental question of how the abundance and function of the gut microbiota of domestic dogs evolved to adapt to the changes in host feeding habits has yet to be addressed. In this study, our comparative analyses of gut metagenomes showed that the abundance of gut microbiota between the two species have some significant differences...
August 2, 2018: AMB Express
https://www.readbyqxmd.com/read/30060774/virgin-olive-oil-and-its-phenol-fraction-modulate-monocyte-macrophage-functionality-a-potential-therapeutic-strategy-in-the-treatment-of-systemic-lupus-erythematosus
#2
Marina Aparicio-Soto, Sergio Montserrat-de la Paz, Marina Sanchez-Hidalgo, Ana Cardeno, Beatriz Bermudez, Francisco J G Muriana, Catalina Alarcon-de-la-Lastra
Monocytes and macrophages are critical effectors and regulators of inflammation and innate immune response, which appear altered in different autoimmune diseases such as systemic lupus erythematosus (SLE). Recent studies suggested that virgin olive oil (VOO) and particularly its phenol compounds might possess preventive effects on different immune-inflammatory diseases, including SLE. Here, we evaluated the effects of VOO (and sunflower oil) on lipopolysaccharide (LPS)-activated peritoneal macrophages from a model of pristane-induced SLE in BALB/c mice, as well as those of the phenol fraction (PF) from VOO on the immune-inflammatory activity and plasticity in monocytes and monocyte-derived macrophages from healthy volunteers...
July 31, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29997049/dietary-intake-and-nutritional-status-in-patients-with-systemic-lupus-erythematosus
#3
Gabriela Pocovi-Gerardino, María Correa-Rodríguez, José Luis Callejas-Rubio, Raquel Ríos-Fernández, Norberto Ortego-Centeno, Blanca Rueda-Medina
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Despite the influence of diet on inflammation, dietary habits in patients with systemic lupus erythematosus (SLE) are not well established. The study objective was to assess dietary intake and nutritional status in SLE patients. PATIENTS AND METHODS: A cross-sectional study was conducted in 92 patients with SLE. Nutritional status was determined by body mass index (BMI) and energy/nutrient distribution of diet was analyzed and compared to a control group...
July 8, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29899295/impact-of-dietary-cholesterol-on-the-pathophysiology-of-infectious-and-autoimmune-disease
#4
REVIEW
Catherine J Andersen
Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29660305/temporomandibular-joint-reconstruction-in-patients-with-autoimmune-connective-tissue-disease
#5
Pushkar Mehra, Charles H Henry, Kamyar R Giglou
PURPOSE: To evaluate clinical outcomes in patients with autoimmune or connective tissue (CT) disease undergoing temporomandibular joint (TMJ) reconstruction. MATERIALS AND METHODS: Patients were divided into 2 groups based on type of TMJ reconstruction. Patients in group 1 (n = 9) underwent autogenous reconstruction and had a diagnosis of rheumatoid arthritis (5), lupus arthritis (1), and psoriatic arthritis (3). Patients in group 2 (n = 2l) had alloplastic reconstruction with a patient-fitted total joint prosthesis (TMJ Concepts, Ventura, CA) and had a diagnosis of rheumatoid arthritis (15), lupus (3), and psoriatic arthritis (3)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29649575/the-interaction-between-environmental-triggers-and-epigenetics-in-autoimmunity
#6
Bruce Richardson
Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. How infections and sun exposure inhibit T cell DNA methylation is unclear. DNA methylation patterns are replicated each time a cell divides in a process that requires DNA methyltransferase one (Dnmt1), which is upregulated as cells enter mitosis, as well as the methyl donor S-adenosylmethionine, created from dietary sources...
July 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29648479/dietary-intervention-and-health-in-patients-with-systemic-lupus-erythematosus-a-systematic-review-of-the-evidence
#7
Marília Cristina Santos de Medeiros, Jussara Cristina Alves Medeiros, Humberto Jefferson de Medeiros, José Carlos Gomes de Carvalho Leitão, Maria Irany Knackfuss
OBJECTIVE: The aim of this study was to evaluate the scientific evidence of dietary intervention, either through diet or supplementation, and its effects on the health of patients with systemic lupus erythematosus. METHODS: Literature searches were conducted using Scopus, PubMed, BioMed Central and Science Direct databases. The terms used for the search were diet, nutritional support, nutrition therapy and systemic lupus erythematosus. RESULTS: Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified...
April 12, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29521297/the-spectrum-of-biopsy-proven-glomerular-disease-in-china-a-systematic-review
#8
REVIEW
Yue Yang, Zheng Zhang, Li Zhuo, Da-Peng Chen, Wen-Ge Li
Background: Chronic kidney disease has become a leading public health concern in China, as it is associated with increased morbidity, mortality, and costs. However, the overall situation regarding common glomerular diseases in China remains unclear. Hence, the aim of this study was to assess the national profile of the common types of glomerulonephritis in China. Methods: We searched Medline, Embase, Cochrane Library, CNKI, SinoMed, VIP, and Wanfang databases for English and Chinese language articles from inception to September 2017...
March 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29225968/metabolic-differences-between-dogs-of-different-body-sizes
#9
Rondo P Middleton, Sebastien Lacroix, Marie-Pier Scott-Boyer, Nikola Dordevic, Adam D Kennedy, Amanda R Slusky, Jerome Carayol, Christina Petzinger-Germain, Alison Beloshapka, Jim Kaput
Introduction: The domesticated dog, Canis lupus familiaris , has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives: This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods: Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29201150/differences-in-the-gut-microbiota-of-dogs-canis-lupus-familiaris-fed-a-natural-diet-or-a-commercial-feed-revealed-by-the-illumina-miseq-platform
#10
Junhyung Kim, Jae-Uk An, Woohyun Kim, Soomin Lee, Seongbeom Cho
Background: Recent advances in next-generation sequencing technologies have enabled comprehensive analysis of the gut microbiota, which is closely linked to the health of the host. Consequently, several studies have explored the factors affecting gut microbiota composition. In recent years, increasing number of dog owners are feeding their pets a natural diet i.e., one consisting of bones, raw meat (such as chicken and beef), and vegetables, instead of commercial feed. However, the effect of these diets on the microbiota of dogs ( Canis lupus familiaris ) is unclear...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29181621/monocyte-chemoattractant-protein-1-as-a-marker-of-systemic-lupus-erythematosus-an-observational-study
#11
Valentina Živković, Tatjana Cvetković, Branka Mitić, Bojana Stamenković, Sonja Stojanović, Biljana Radovanović-Dinić, Vladimir Jurišić
There is a pivotal need for new markers to be tested in every day clinical practice for systemic lupus erythematosus (SLE) and lupus nephritis (LN). The levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 SLE patients (27 with LN and 45 without LN involvement) and 30 healthy individuals were studied to establish their clinical significance. The SLE Disease Activity Index (SLEDAI) was used to establish the disease activity. Urine and serum MCP-1 was determined using the sandwich enzyme immunosorbent assay...
June 2018: Rheumatology International
https://www.readbyqxmd.com/read/29152188/prey-use-by-dingoes-in-a-contested-landscape-ecosystem-service-provider-or-biodiversity-threat
#12
Damian S Morrant, Christopher M Wurster, Christopher N Johnson, James R A Butler, Bradley C Congdon
In Australia, dingoes ( Canis lupus dingo ) have been implicated in the decline and extinction of a number of vertebrate species. The lowland Wet Tropics of Queensland, Australia is a biologically rich area with many species of rainforest-restricted vertebrates that could be threatened by dingoes; however, the ecological impacts of dingoes in this region are poorly understood. We determined the potential threat posed by dingoes to native vertebrates in the lowland Wet Tropics using dingo scat/stomach content and stable isotope analyses of hair from dingoes and potential prey species...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29141574/anti-inflammatory-activity-of-extra-virgin-olive-oil-polyphenols-which-role-in-the-prevention-and-treatment-of-immune-mediated-inflammatory-diseases
#13
Carmela Santangelo, Rosariax Vari, Beatrice Scazzocchio, Patrizia De Sanctis, Claudio Giovannini, Massimo D'Archivio, Roberta Masella
BACKGROUND AND OBJECTIVE: Altered inflammatory response characterizes chronic immunemediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such as cardiovascular diseases, type 2 diabetes and cancer...
2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29095019/microbiota-and-oxidant-antioxidant-balance-in-systemic-lupus-erythematosus
#14
Sonia González, Isabel Gutie Rrez-Díaz, Patricia Lo Pez, Ana Suárez, Tania Fernández-Navarro, Borja Sánchez, Abelardo Margolles
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic infl ammatory disease of autoimmune nature, in which oxidative stress is implicated. AIM: Compare the concentrations of dietary and blood antioxidants, as well as gut microbiota, with serum malondialdehyde (MDA) and C reactive protein (CRP) in 21 subjects suffering from non-active systemic lupus erythematosus (SLE) and 21 age and gender-matched controls. METHODS: General biochemical parameters and CRP were determined by enzymatic methods: copper, zinc and selenium by inductively coupled plasma mass spectrometry (ICP-MS), MDA and total antioxidant capacity (TAC) by spectrophotometric methods, gut microbiota by metagenomic analyses and dietary intake by means of food frequency questionnaire...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28951833/surrogate-hosts-hunting-dogs-and-recolonizing-grey-wolves-share-their-endoparasites
#15
Ines Lesniak, Mathias Franz, Ilja Heckmann, Alex D Greenwood, Heribert Hofer, Oliver Krone
Understanding how closely related wildlife species and their domesticated counterparts exchange or share parasites, or replace each other in parasite life cycles, is of great interest to veterinary and human public health, and wildlife ecology. Grey wolves (Canis lupus) host and spread endoparasites that can either directly infect canid conspecifics or their prey serving as intermediate hosts of indirectly transmitted species. The wolf recolonization of Central Europe represents an opportunity to study parasite transmission dynamics between wildlife and domestic species for cases when a definitive host returns after local extinction - a situation equivalent to a 'removal experiment'...
December 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28877244/the-role-of-dietary-sodium-intake-on-the-modulation-of-t-helper-17-cells-and-regulatory-t-cells-in-patients-with-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#16
Rossana Scrivo, Laura Massaro, Cristiana Barbati, Marta Vomero, Fulvia Ceccarelli, Francesca Romana Spinelli, Valeria Riccieri, Alessandra Spagnoli, Cristiano Alessandri, Giovambattista Desideri, Fabrizio Conti, Guido Valesini
We aimed at investigating whether the frequency and function of T helper 17 (Th17) and regulatory T cells (Treg) are affected by a restriction of dietary sodium intake in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We enrolled RA and SLE patients not receiving drugs known to increase urinary sodium excretion. Patients underwent a dietary regimen starting with a restricted daily sodium intake followed by a normal-sodium daily intake. The timepoints were identified at baseline (T0), after 3 weeks of low-sodium dietary regimen (T3), after 2 weeks of normal-sodium dietary regimen (T5)...
2017: PloS One
https://www.readbyqxmd.com/read/28752494/epigenetics-in-sle
#17
REVIEW
Christian Michael Hedrich
PURPOSE OF REVIEW: Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of clinically evident disease. RECENT FINDINGS: Over the past decade, epigenetic events moved into the focus of research targeting the molecular pathophysiology of SLE...
September 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28637300/commercial-rodent-diets-differentially-regulate-autoimmune-glomerulonephritis-epigenetics-and-microbiota-in-mrl-lpr-mice
#18
COMPARATIVE STUDY
Michael R Edwards, Rujuan Dai, Bettina Heid, Thomas E Cecere, Deena Khan, Qinghui Mu, Catharine Cowan, Xin M Luo, S Ansar Ahmed
The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr (MRL/MpJ-Faslpr/J) mice were subjected to the same housing conditions and given one of the three diets: Teklad 7013 containing isoflavone-rich soy and alfalfa, Harlan 2018 isoflavone-rich soy-based diet or Research Diets Inc...
June 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28473038/broad-concepts-in-management-of-systemic-lupus-erythematosus
#19
Vaidehi R Chowdhary
Systemic lupus erythematosus is a multisystem autoimmune disease with protean manifestation. Although commonly seen in young women, it can affect men as well as elderly patients. Approach to treatment is multidisciplinary, involves defining the extent of organ involvement, and distinguishing between active manifestations and damage. The mainstay of therapy is judicious use of immunosuppressive medications. Long-term follow-up to address morbidity arising from treatment complications, disease damage, and increased cardiovascular risk is essential...
May 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28364315/mucosal-healing-of-crohn-s-disease-in-a-patient-with-concurrent-systemic-lupus-erythematosus-using-infliximab
#20
Yuka Kagaya, Hirotsugu Sakamoto, Tomonori Yano, Keijiro Sunada, Alan Kawarai Lefor, Toshiro Niki, Hironori Yamamoto
We describe a patient with Crohn's disease (CD) concurrent with systemic lupus erythematosus (SLE). Continuous prednisolone and cyclosporine treatment resulted in no recurrent symptoms. However, diarrhea, vomiting, and fever occurred for approximately 3 months. A colonoscopy was then performed, which showed a discontinuous cobblestone appearance and longitudinal ulcers extending from the sigmoid colon to the descending colon and distal ileum. A biopsy revealed a noncaseating granulomatous lesion in the colonic mucosa...
June 2017: Clinical Journal of Gastroenterology
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