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C-PTSD therapies

C Rometsch-Ogioun El Sount, P Windthorst, J Denkinger, K Ziser, C Nikendei, D Kindermann, J Ringwald, V Renner, S Zipfel, F Junne
OBJECTIVE: Chronic pain in patients with posttraumatic stress disorder (PTSD) is a frequent symptom and a complicating factor in the treatment of patients. The study' purpose is to systematically review the scientific literature on patients' characteristics and the effects of specific interventions implemented for the treatment of chronic pain in traumatized refugees. METHOD: A systematic search of the current literature was conducted in PubMed and Web of Science, from 1996 to 2017...
July 30, 2018: Journal of Psychosomatic Research
Natalie E Hundt, Tracey L Smith, John C Fortney, Jeffrey A Cully, Melinda A Stanley
Many veterans do not engage in needed mental health care. To address this problem, we need to understand these patients' experiences from the very start of their care, which includes the assessment and diagnosis process and the communication of that diagnosis to the patient. The patient's reaction to this process can set the tone for the patient's relationship with the mental health system and his or her therapist, yet therapists often receive little training in how to most effectively provide a diagnosis to patients...
July 30, 2018: Psychological Services
Lisa Amaya-Jackson, Dana Hagele, John Sideris, Donna Potter, Ernestine C Briggs, Leila Keen, Robert A Murphy, Shannon Dorsey, Vanessa Patchett, George S Ake, Rebecca Socolar
BACKGROUND: A model for statewide dissemination of evidence-based treatment (EBT) for traumatized youth was piloted and taken to scale across North Carolina (NC). This article describes the implementation platform developed, piloted, and evaluated by the NC Child Treatment Program to train agency providers in Trauma-Focused Cognitive Behavioral Therapy using the National Center for Child Traumatic Stress Learning Collaborative (LC) Model on Adoption & Implementation of EBTs. This type of LC incorporates adult learning principles to enhance clinical skills development as part of training and many key implementation science strategies while working with agencies and clinicians to implement and sustain the new practice...
July 28, 2018: BMC Health Services Research
Alan L Peterson, Edna B Foa, Tabatha H Blount, Carmen P McLean, Dhiya V Shah, Stacey Young-McCaughan, Brett T Litz, Richard P Schobitz, Diane T Castillo, Timothy O Rentz, Jeffrey S Yarvis, Katherine A Dondanville, Brooke A Fina, Brittany N Hall-Clark, Lily A Brown, Bryann R DeBeer, Vanessa M Jacoby, Allison K Hancock, Douglas E Williamson, Wyatt R Evans, Samantha Synett, Casey Straud, Hunter R Hansen, Eric C Meyer, Martin A Javors, Allah-Fard M Sharrieff, Jose Lara-Ruiz, Lauren M Koch, John D Roache, Jim Mintz, Terence M Keane
Combat-related posttraumatic stress disorder (PTSD) is the most common psychological health condition in military service members and veterans who have deployed to the combat theater since September 11, 2001. One of the highest research priorities for the Department of Defense and the Department of Veterans Affairs is to develop and evaluate the most efficient and efficacious treatments possible for combat-related PTSD. However, the treatment of combat-related PTSD in military service members and veterans has been significantly more challenging than the treatment of PTSD in civilians...
July 25, 2018: Contemporary Clinical Trials
Katherine E Miller, Rachel L Micol, Joanne L Davis, Christopher C Cranston, Kristi E Pruiksma
OBJECTIVE: This report aims to extend previous findings on predictors of treatment dropout and response within nightmare treatment. METHOD: Factors predicting treatment noninitiation, dropout, and response were examined in 70 trauma-exposed individuals treated in a randomized controlled trial of 2 conditions (exposure [EX] and nonexposure) of a therapy for trauma nightmares. RESULTS: Together, treatment noninitiation and dropout was predicted by younger age for the EX condition only and by fewer nights with nightmares at baseline for both conditions...
July 19, 2018: Psychological Trauma: Theory, Research, Practice and Policy
C Van Woudenberg, E M Voorendonk, H Bongaerts, H A Zoet, M Verhagen, C W Lee, A van Minnen, A De Jongh
Background: There is room for improvement regarding the treatment of severe post-traumatic stress disorder (PTSD). Intensifying treatment to increase patient retention is a promising development. Objective: The aim of this study was to determine the effectiveness of an intensive trauma-focused treatment programme over 8 days for individuals suffering from severe PTSD. Method: Treatment was provided for 347 PTSD patients (70% women; mean age = 38.32 years, SD  = 11.69) and consisted of daily sessions of prolonged exposure and eye movement desensitization and reprocessing (EMDR) therapy (16 sessions in total), physical activity, and psycho-education...
2018: European Journal of Psychotraumatology
Melissa L Mehalick, Amanda C Glueck
In this review, we discuss the comorbidity of traumatic brain injury (TBI) and pain among civilians and military members, the common causes of pain resulting from TBI, and offer insight about the therapeutic management of TBI symptoms and pain. Traumatic brain injury (TBI) is a debilitating health problem and one of the most common post-TBI symptoms is pain, which can contribute to psychological issues such as Post-traumatic stress disorder (PTSD) and depression. Headache pain appears to be the most common type of pain that results from TBI, yet pain can also be more widespread...
July 11, 2018: Brain Injury: [BI]
Jennifer C Kanady, Lisa S Talbot, Shira Maguen, Laura D Straus, Anne Richards, Leslie Ruoff, Thomas J Metzler, Thomas C Neylan
STUDY OBJECTIVES: Our study aims were to examine (1) the association between fear of sleep and posttraumatic stress disorder (PTSD) symptoms, (2) the association between fear of sleep and subjective and objective insomnia symptoms and disruptive behaviors during sleep, and (3) whether fear of sleep decreases following cognitive behavioral therapy for insomnia (CBT-I). METHODS: Forty-five adults with PTSD and insomnia participated in the study. Fear of sleep was assessed using the Fear of Sleep Inventory; PTSD symptoms were assessed using the Clinician Administered PTSD Scale; and sleep disturbance symptoms were assessed using the Insomnia Severity Index, polysomnography, sleep diaries, and the Pittsburgh Sleep Quality Index Addendum for PTSD...
July 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Sadie E Larsen, C J Eubanks Fleming, Patricia A Resick
OBJECTIVE: Although there are several evidence-based treatments that are effective in mitigating the symptoms of posttraumatic stress disorder (PTSD), rates of nonresponse to treatment as well as treatment dropout remain high. In order to determine which symptoms remain most problematic at the end of treatment for PTSD, the present study examined residual symptoms in a treatment study that evaluated the effects of cognitive processing therapy (CPT) and prolonged exposure (PE). METHOD: The sample consisted of 108 female rape survivors who initially met criteria for PTSD and who were then randomized into and completed either CPT or PE...
July 2, 2018: Psychological Trauma: Theory, Research, Practice and Policy
Katie A Ragsdale, Michael A Gramlich, Deborah C Beidel, Sandra M Neer, Emily G Kitsmiller, Krystal I Morrison
Research indicates that exposure therapy is efficacious for combat-related posttraumatic stress disorder (PTSD) comorbid with traumatic brain injury (TBI) as is shown by reduced PTSD treatment outcome scores. What is unknown, however, is whether the process of fear extinction is attenuated in veterans with TBI history. Increased PTSD symptomatology and possible cognitive deficits associated with TBI sequelae may indicate additional or longer exposure sessions to achieve habituation and extinction comparable to individuals without TBI history...
July 2018: Behavior Therapy
Craig J Bryan, Feea R Leifker, David C Rozek, AnnaBelle O Bryan, Mira L Reynolds, D Nicolas Oakey, Erika Roberge
OBJECTIVE: This study aimed to examine the effectiveness of cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) when administered on a daily basis during a 2-week period of time. METHOD: In an open-label, prospective cohort pilot trial, 20 U.S. military personnel and veterans diagnosed with PTSD or subthreshold PTSD participated in 12 daily sessions of CPT. Primary outcomes included Clinician Administered PTSD Scale for DSM-5 and PTSD Checklist for DSM-5 scores...
June 19, 2018: Journal of Clinical Psychology
Jeffrey S Bedwell, Corey J Bohil, Mark B Neider, Michael A Gramlich, Sandra M Neer, John P OʼDonnell, Deborah C Beidel
There is a need for a better understanding of underlying pathology in posttraumatic stress disorder (PTSD) to develop more effective treatments. The late positive potential (LPP) amplitude from electroencephalogram has been used to assess individual differences in emotional reactivity. There is evidence that olfaction is particularly important in emotional processing in PTSD. The current study examined LPP amplitudes in response to olfactory stimuli in 24 combat veterans with PTSD and 24 nonmilitary/non-PTSD controls...
June 2018: Journal of Nervous and Mental Disease
Valerie C Joiner, Frederick P Buttell
OBJECTIVE: This study investigated the usefulness of the trauma intervention, trauma-focused cognitive behavioral therapy (TF-CBT), for adolescents in residential treatment. METHOD: The study employed a secondary analysis of 132 adolescent trauma cases collected from youth while in a residential treatment facility in Mississippi. RESULTS: Analysis indicated that clients showed significant decreases in posttraumatic stress disorder (PTSD) severity scores after receiving TF-CBT in residential care...
July 2018: Journal of Evidence-informed Social Work
Susan Munsey, Heather E Miller, Terence Rugg
GenerateHope (GH) is a San Diego-based 501c3 nonprofit organization providing fully integrated, comprehensive rehabilitation services to adult female survivors of sex trafficking. While best practices for working with survivors of sex trafficking are slowly emerging, to date, there have been few publications on this subject and little data on either short- or long-term outcomes from the many and varied programs nationwide. This paper examines the GH residential program and provides early outcome results for residents living at the GH program between six and 12 months...
July 2018: Journal of Evidence-informed Social Work
Julian D Ford, Damion J Grasso, Carolyn A Greene, Michelle Slivinsky, Jason C DeViva
A randomized controlled trial pilot study (; NCT01228539) with N = 31 U.S. male military recent combat veterans with PTSD and severe anger problems was conducted comparing 10-session individual therapy versions of Trauma Affect Regulation: Guide for Education and Therapy (TARGET) versus prolonged exposure (PE). TARGET had fewer drop-outs than PE (i.e., 29% vs. 64%). At post-test, improvements were found for both interventions in increased emotion regulation and hope, and reduced PTSD symptoms, hostility, experiential avoidance, and mental health problems...
April 23, 2018: Clinical Psychology & Psychotherapy
Delin Sun, Sarah L Davis, Courtney C Haswell, Chelsea A Swanson, Kevin S LaBar, John A Fairbank, Rajendra A Morey
Posttraumatic stress disorder (PTSD) is a prevalent, chronic disorder with high psychiatric morbidity; however, a substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thickness correlations are associated with PTSD, but the effects of remitted symptoms on network topology remain essentially unexplored. In this cross-sectional study, US military veterans ( N  = 317) were partitioned into three diagnostic groups, current PTSD (CURR-PTSD, N  = 101), remitted PTSD with lifetime but no current PTSD (REMIT-PTSD, N  = 35), and trauma-exposed controls (CONTROL, n  = 181)...
2018: Frontiers in Psychiatry
Kim L Felmingham, Daniel V Zuj, Ken Chia Ming Hsu, Emma Nicholson, Matthew A Palmer, Kimberley Stuart, James C Vickers, Gin S Malhi, Richard A Bryant
The low expression Met allele of the BDNF Val66Met polymorphism is associated with impaired fear extinction in healthy controls, and poorer response to exposure therapy in patients with Posttraumatic Stress Disorder (PTSD). Given that fear extinction underlies exposure therapy, this raises the question of the impact of BDNFVal66Met polymorphism on fear extinction in PTSD, yet this question has not yet been examined. One hundred and six participants (22 PTSD, 46 trauma-exposed controls (TC) and 38 non-trauma exposed controls (NTC)) completed a fear conditioning and extinction task and saliva samples were taken for DNA extraction and genotyped for the BDNF Val66Met polymorphism...
May 2018: Psychoneuroendocrinology
Quang A Le, Jason N Doctor, Lori A Zoellner, Norah C Feeny
PURPOSE: Health outcomes may depend on which treatment is received, whether choice of treatment is given, and whether a received treatment is the preferred therapy. We examined the effects of these key factors on the EuroQol-5D (EQ-5D-3L) in patients with PTSD. METHODS: Two hundred patients aged 18-65 years with PTSD diagnosis enrolled in a doubly randomized preference trial (DRPT) examining treatment, choice of treatment, and treatment-preference effects of prolonged exposure therapy (PE) and pharmacotherapy with sertraline (SER) (clinicaltrials...
June 2018: Quality of Life Research
Allison A Feduccia, Michael C Mithoefer
MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying psychological and neurological mechanisms for the robust effects in mitigating PTSD are being investigated in animal models and in studies of healthy volunteers...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Eric C Meyer, Sheila B Frankfurt, Nathan A Kimbrel, Bryann B DeBeer, Suzy B Gulliver, Sandra B Morrisette
OBJECTIVES: Posttraumatic stress disorder (PTSD) strongly predicts greater disability and lower quality of life (QOL). Mindfulness-based and other third-wave behavior therapy interventions improve well-being by enhancing mindfulness, self-compassion, and psychological flexibility. We hypothesized that these mechanisms of therapeutic change would comprise a single latent factor that would predict disability and QOL after accounting for PTSD symptom severity. METHOD: Iraq and Afghanistan war veterans (N = 117) completed a study of predictors of successful reintegration...
July 2018: Journal of Clinical Psychology
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