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Bipolar type 2

Lucy Sykes, Josephine Haddon, Thomas M Lancaster, Arabella Sykes, Karima Azzouni, Niklas Ihssen, Anna L Moon, Tzu-Ching E Lin, David E Linden, Michael J Owen, Michael C O'Donovan, Trevor Humby, Lawrence S Wilkinson, Kerrie L Thomas, Jeremy Hall
Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic variation in CACNA1C contributes to risk for these disorders is however not fully known. Both schizophrenia and bipolar disorder are associated with impairments in reversal learning (RL), which may contribute to symptoms seen in these conditions. We used a translational RL paradigm to investigate whether genetic variation in CACNA1C affects RL in both humans and transgenic rats...
October 10, 2018: Schizophrenia Bulletin
Shen-Li Chen, Yi-Cih Wu
High-voltage n-channel lateral-diffused metal-oxide-semiconductor field-effect transistor (nLDMOS) components, fabricated by a TSMC 0.25-m 60-V bipolar-CMOS-DMOS (BCD) process with drain-side embedded silicon-controlled rectifier (SCR) of the n-p-n-arranged and p-n-p-arranged types, were investigated, in order to determine the devices' electrostatic discharge (ESD)-sensing behavior and capability by discrete anode engineering. As for the drain-side n-p-n-arranged type with discrete-anode manners, transmission⁻line⁻pulse (TLP) testing results showed that the ESD ability (It2 value) was slightly upgraded...
October 6, 2018: Sensors
Yusuke Kawamura, Kenji Ikeda, Junichi Shindoh, Yuta Kobayashi, Kayoko Kasuya, Shunichiro Fujiyama, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Masaji Hashimoto, Hiromitsu Kumada
BACKGROUND & AIMS: The aim of this study was to clarify the utility of a no-touch pincer ablation procedure that uses bipolar electrodes to prevent intrasubsegmental tumor recurrence after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC) compared to surgical resection. METHODS: We evaluated 175 consecutive patients with HCC (single nodule, tumor diameter ≤30 mm) who underwent surgical resection (146 received partial resection) and 313 patients who received RFA; 277 patients received touch ablation using a monopolar or bipolar RFA device, and 36 received no-touch ablation using a bipolar RFA device...
October 2, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Brian M Quigley, Rebecca J Houston, Daniel Antonius, Maria Testa, Kenneth E Leonard
Diagnosis of mental illness (MI) inconsistently predicts aggressive behavior although co-occurrence of substance use appears to increase the frequency of aggression in MI populations. We propose that alcohol use should moderate the relationship between mental disorders marked by deficits in self-control and aggression and victimization. In the present study, alcohol use, physical aggression perpetration, physical aggression victimization, injury and psychiatric symptoms were assessed in a sample of 297 substance use disorder patients (102 women; M age = 38...
September 27, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Júlia Fonseca de Morais Caporali, Ludimila Labanca, Kyonis Rodrigues Florentino, Bárbara Oliveira Souza, Denise Utsch Gonçalves
BACKGROUND: The vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) has been used to assess the function of the vestibulospinal motor tract and is a candidate biomarker to predict and monitor the human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy (HAM). This study determined the agreement and reliability of this exam. METHODS: Galvanic-VEMP was performed in 96 participants, of which 24 patients presented HAM, 27 HTLV-1-asymptomatic carriers, and 45 HTLV-1-negative asymptomatic controls...
2018: PloS One
Shinji Ueno, Daiki Inooka, Ayami Nakanishi, Satoshi Okado, Shunsuke Yasuda, Taro Kominami, Akira Sayo, Takeshi Morimoto, Mineo Kondo, Satoshi Katagiri, Takaaki Hayashi, Hiroko Terasaki
PURPOSE: To report the clinical course of eyes with paraneoplastic retinopathy caused by an autoantibody against transient receptor potential cation channel, subfamily M, member 1 (TRPM1). METHODS: Ten paraneoplastic retinopathy patients with retinal ON-bipolar cell dysfunction, including six melanoma-associated retinopathy, from eight institutions in Japan were evaluated for the presence of an anti-TRPM1 antibody. The results of ophthalmic examinations and the presence of anti-TRPM1 antibody were analyzed...
September 26, 2018: Retina
Y Zhang, K M Hansson, T Liu, K Magnell, Y Huang, N G Carlson, B K Kishore
AIM: Therapeutic use of lithium in bipolar disorder is limited by the development of nephrogenic diabetes insipidus (NDI). We reported that pharmacological blockade of P2Y12 receptor (R) with clopidogrel or prasugrel significantly ameliorated lithium-induced NDI in rodents. Using mice genetically lacking P2Y12 -R we evaluated whether the observed amelioration is mediated through P2Y12 -R. METHODS: P2ry12-/- mouse line (C57/BL6) was rederived from cryopreserved embryos of the knockout (KO) mice generated by Deltagen Inc...
September 26, 2018: Acta Physiologica
Qi Chen, Catharina A Hartman, Jan Haavik, Jaanus Harro, Kari Klungsøyr, Tor-Arne Hegvik, Rob Wanders, Cæcilie Ottosen, Søren Dalsgaard, Stephen V Faraone, Henrik Larsson
Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with other psychiatric conditions in adults. Yet, less is known about its relationship with common metabolic disorders and how sex and ageing affect the overall comorbidity patterns of adult ADHD. We aimed to examine associations of adult ADHD with several common psychiatric and metabolic conditions. Through the linkage of multiple Swedish national registers, 5,551,807 adults aged 18 to 64 years and living in Sweden on December 31, 2013 were identified and assessed for clinical diagnoses of adult ADHD, substance use disorder (SUD), depression, bipolar disorder, anxiety, type 2 diabetes mellitus (T2DM), and hypertension...
2018: PloS One
Jaime Osuna-Luque, Ángel Rodríguez-Ramos, María Del Mar Gámez-Del-Estal, Manuel Ruiz-Rubio
The neurotransmitters dopamine and serotonin participate in specific behavioral neuromuscular mechanisms in the nematode Caenorhabditis elegans . Dopamine is involved in the gentle touch response and serotonin in the pharyngeal pumping rate. In its genome, the worm presents genes encoding dopamine and serotonin receptors orthologous to those of human genes. Risperidone and aripiprazole are a class of drugs known as atypical antipsychotics commonly used to treat schizophrenia, bipolar disorder, and irritability associated with autism...
2018: Journal of Experimental Neuroscience
Macrene Alexiades, Gilly Munavalli, David Goldberg, Dany Berube
BACKGROUND: A bipolar fractional radiofrequency (RF) device was developed to generate cutaneous thermal injuries using a temperature-controlled microneedle electrode array. OBJECTIVE: Evaluate safety and efficacy of a novel subcutaneous microneedle RF for treatment of posterolateral thigh cellulite. METHODS: The study design was an institutional review board-approved multicenter clinical trial after a per-protocol analysis. Fifty subjects with Nurnberger-Muller Grade II or III cellulite were enrolled at 4 treatment centers and received 1 subcutaneous microneedle RF treatment (67°C/4-second duration)...
October 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Kürşat Altınbaş, Dilek Yeşilbaş, Bahri İnce, Alparslan Cansız, Fatma Sılan, Öztürk Özdemir, Sinan Gülöksüz
OBJECTIVE: There is a lack of evidence regarding clinical predictors for the treatment response to lithium, which is the main stay treatment option for bipolar disorder. Studies that examined the mechanistic action of lithium revealed that glycogen synthase kinase 3β (GSK-3β) enzymeinhibition was important in regard to treatment responses. Based on this background, we aimed to investigate the association between responses to lithium treatment and five different polymorphisms of GSK-3β...
2018: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt, Per Ivar Finseth
BACKGROUND: About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition (BD due to TBI). We investigated whether these patients have similar clinical characteristics as previously described in BD due to TBI (i.e. more aggression and irritability and an increased hypomania/mania:depression ratio) and other distinct clinical characteristics...
September 10, 2018: International Journal of Bipolar Disorders
Michael S Broder, Mallik Greene, Eunice Chang, Ann Hartry, Maëlys Touya, Jennifer Munday, Tingjian Yan
PURPOSE: Schizophrenia (SCZ) and bipolar disorder (BD) are typically viewed as nonconcurrent psychiatric disorders, yet patients may experience mood and SCZ symptoms simultaneously. Several studies have shown overlap between SCZ and BD symptoms and susceptibility genes. This study explored the following: (1) patterns of administrative claims; (2) demographic characteristics and comorbidities; (3) health care resource use; and (4) health care costs in patients with diagnoses of SCZ, type I BD (BD-I), and both in a real-world setting...
September 4, 2018: Clinical Therapeutics
Alfredo Ardila
Acquired brain pathology can be associated with diverse psychiatric manifestations. Three major types of psychiatric disorders potentially found in cases of acquired brain pathology are examined: (1) psychosis, (2) mood disorders, and (3) personality disorders with special emphasis in so-called "acquired psychopathy." Two types of psychotic manifestations are reviewed: (a) Schizophrenia-like psychosis; (b) Other delusional disorder, specifically, somatoparaphrenia and delusional misidentification syndromes, which include reduplicative paramnesias, Capgras syndrome, Frégoli syndrome, and "doubles of the self-syndrome...
September 5, 2018: Applied Neuropsychology. Adult
Samantha Meltzer-Brody, Helen Colquhoun, Robert Riesenberg, C Neill Epperson, Kristina M Deligiannidis, David R Rubinow, Haihong Li, Abdul J Sankoh, Christine Clemson, Amy Schacterle, Jeffrey Jonas, Stephen Kanes
BACKGROUND: Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently needed. We assessed brexanolone injection (formerly SAGE-547 injection), a positive allosteric modulator of γ-aminobutyric-acid type A (GABAA ) receptors, for the treatment of moderate to severe post-partum depression. METHODS: We did two double-blind, randomised, placebo-controlled, phase 3 trials, at 30 clinical research centres and specialised psychiatric units in the USA...
September 22, 2018: Lancet
Daniel G Ehlinger, Kathryn G Commons
Human genetic variation in the gene CACNA1C, which codes for the alpha-1c subunit of Cav1.2 L-type calcium channels (LTCCs), has been broadly associated with enhanced risk for neuropsychiatric disorders including major depression, bipolar and schizophrenia. Little is known about the specific neural circuits through which CACNA1C and Cav1.2 LTCCs impact disease etiology. However, serotonin (5-HT) neurotransmission has been consistently implicated in these neuropsychiatric disorders and Cav1.2 LTCCs may influence 5-HT neuron activity during relevant behavioral states such as stress...
August 31, 2018: Neuropharmacology
Jian-Ping He, Diana Paksarian, Kathleen R Merikangas
OBJECTIVE: To estimate associations between physical activity (PA) and a broad range of lifetime mental disorders among adolescents, and to evaluate whether the context of sports participation impacts these associations. METHODS: The sample included 6,483 13-18 year-olds from the National Comorbidity Survey Adolescent Supplement. Adolescents completed face-to-face psychiatric interviews and a parent provided diagnostic and other family-level information on the participating adolescent by completing a self-administered questionnaire...
August 28, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Zaid Tanvir, Ralph F Nelson, Kathleen DeCicco-Skinner, Victoria P Connaughton
Prolonged hyperglycemia can alter retinal function ultimately resulting in blindness. Zebrafish adults exposed to alternating 2% glucose conditions display a 3x increase in blood sugar levels. After 4 weeks of treatment, electroretinograms (ERGs) were recorded from isolated, perfused, in vitro eyecups. Control animals were exposed either to alternating 2% mannitol (osmotic control) or alternating water (handling control). Two types of ERGs were recorded: (1) native ERGs measured using white light stimuli and media without synaptic blockers and (2) spectral ERGs measured with an AMPA/KA antagonist, isolating photoreceptor-to-ON-bipolar cell synapses, and a spectral protocol that separated R, G, B, and UV cone signals...
August 29, 2018: Disease Models & Mechanisms
Gordon Parker, Stacey McCraw, Gabriela Tavella, Dusan Hadzi-Pavlovic
Mood disorders may lead to major life consequences. This study builds on our preliminary examination of the impact of an extensive set of consequences and was undertaken in a larger clinical sample. Two hundred and forty four adults diagnosed with either unipolar depressive disorder or a bipolar disorder (type I or II) were administered an online survey of 60 items, listing potential consequences of having a mood disorder. Participants estimated the degree of impact (0-100) of each consequence on their life initially, and in the longer term...
August 12, 2018: Psychiatry Research
Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima
Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele...
August 15, 2018: Cerebral Cortex
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