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Ovarian transplantation

Tae-Hee Kim, Jong Ho Choi, Yesl Jun, Seung Mook Lim, Sohae Park, Jin-Young Paek, Sang-Hoon Lee, Ji-Young Hwang, Gi Jin Kim
Placenta-derived mesenchymal stem cells (PD-MSCs) have numerous advantages over other adult MSCs that make them an attractive cell source for regenerative medicine. Here, we demonstrate the therapeutic effect of PD-MSCs in ovariectomized (Ovx) rats and compare their efficacy when generated via a conventional monolayer culture system (2D, naïve) and a spheroid culture system (3D, spheroid). PD-MSC transplantation significantly increased the estradiol level in Ovx rats compared with the non-transplantation (NTx) group...
October 17, 2018: Scientific Reports
Swati Agarwal, Faisal A Alzahrani, Asif Ahmed
BACKGROUND: Throughout history, menopause has been regarded as a transition in a woman's life. With the increase in life expectancy, women now spend more than a third of their lives in menopause. During these years, women may experience intolerable symptoms both physically and mentally, leading them to seek clinical advice. It is imperative for healthcare providers to improve the quality of life by reducing bothersome menopausal symptoms and preventing disorders such as osteoporosis and atherosclerosis...
October 14, 2018: International Journal of Molecular Sciences
C-H Lin, S-N Chang, C-H Chen
OBJECTIVE: Hormonal changes, in either men or women experiencing chronic kidney disease, cause decreased libido, erectile dysfunction, dysmenorrhea, and ovarian dysfunction, all of which may contribute to infertility. Patients' endocrinal and sexual function could be rapidly restored after successful renal transplantation (RTx), which may assist in achieving a successful pregnancy. However, fetuses will be exposed to the immunosuppressive agents passed on from the female recipients, which may be another potential factor leading to a poor fetal outcome...
October 2018: Transplantation Proceedings
Sara Farag, Pamela Frazzini Padilla, Katherine A Smith, Rebecca Flyckt, Michael L Sprague, Stephen E Zimberg
STUDY QUESTION: Is there perfusion to the fallopian tubes in ex-vivo and in-vivo uteri at the time of total laparoscopic hysterectomy (TLH), as observed using laser angiography with indocyanine green (ICG)? SUMMARY ANSWER: The fallopian tubes may have perfusion from the utero-ovarian vasculature alone. WHAT IS KNOWN ALREADY: The fallopian tubes are perfused by the uterine and utero-ovarian vessels. Perfusion can be measured using laser angiography with ICG...
October 10, 2018: Human Reproduction
Sevim Tuncer, Remzi Atilgan, Şehmus Pala, Tuncay Kuloğlu, Gökhan Artaş, Süleyman Aydın
OBJECTIVES: This study aimed to compare the effects of N-acetylcysteine and benfotiamine in protection of ovarian tissue from ischemia caused by slow neovascularization injury due to intraperitoneal ovarian autotransplant in rats. MATERIALS AND METHODS: Twenty-eight female rats were divided into 4 groups, each containing 7 rats. Group 1 only had the abdomen opened and closed, group 2 was the transplant-only group, group 3 received benfotiamine for 3 weeks starting 1 day before the transplant procedure, and group 4 received N-acetylcysteine for 3 weeks starting 1 day before the transplant procedure...
October 5, 2018: Experimental and Clinical Transplantation
Michael von Wolff, Nicole Sänger, Jana Liebenthron
No abstract text is available yet for this article.
October 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Yantao He, Dongmei Chen, Lingling Yang, Qiaoni Hou, Huiming Ma, Xian Xu
With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs (BMSCs) improve the ovarian reserve, which mainly depends on homing and paracrine activities. Furthermore, paracrine factors secreted by these stem cells play an important role in ovarian recovery. Relevant studies indicate that BMSC transplantation has some positive effects on the treatment of POF in animals, but BMSCs are not widely applied in clinical therapy...
October 4, 2018: Stem Cell Research & Therapy
Marjorie P David, Rajkumar Venkatramani, Dolores H Lopez-Terrada, Angshumoy Roy, Ninad Patil, Kevin E Fisher
A 12-yr-old normocalcemic female treated for a ruptured ovarian juvenile granulosa cell tumor at an outside hospital presented for exploratory laparotomy and gross surgical debulking of pelvic recurrence. Morphologically, the tumor was composed of sheets and nests of small blue cells forming cysts of various sizes and focal mucinous differentiation. Epithelial membrane antigen (EMA), patchy inhibin, and strong and diffuse p53 immunoreactivity were also observed. A revised diagnosis of mixed sex cord stromal tumor with heterologous elements was favored because of the inhibin immunoreactivity...
October 2018: Cold Spring Harbor Molecular Case Studies
Ashraf Hassanpour, Tahereh Talaei-Khozani, Elias Kargar-Abarghouei, Vahid Razban, Zahra Vojdani
BACKGROUND: The increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to find a safe and transplantable alternative ovary. A bioengineered ovary is one of the strategies on which the researchers have recently been working. An engineered ovary should be able to mimic the natural ovary aspects. Recent studies suggest that the decellularized organ-specific extracellular matrix-based scaffolds can serve as a native niche to bioengineering artificial organs...
September 26, 2018: Stem Cell Research & Therapy
Sherman J Silber, Michael DeRosa, Sierra Goldsmith, Yuting Fan, Leilani Castleman, Jeffrey Melnick
PURPOSE: To report the results of cryopreserved ovary tissue transplantation for leukemia and other cancers, in a single US center. METHODS: One hundred eight females between age 6 and (median age 24) 35 were referred for possible ovary tissue cryopreservation over a 20-year period, with either slow freeze or vitrification. Thus far 13 patients returned up to 18 years later to have their tissue transplanted back. RESULTS: All 13 patients had return of ovarian function 5 months post transplant with regular menstrual cycling...
September 25, 2018: Journal of Assisted Reproduction and Genetics
Zhanfei Li, Huibing Liu, Jinghe Lang, Guorui Zhang, Zhengxing He
Research has strongly suggested that the features of endometriosis serve as a precursor lesion of ovarian cancer. Cisplatin (CDDP) is the preferred drug against these cancer types. The present study investigated the effects of CDDP on surgically induced endometriosis in a rat model. Endometriosis was surgically induced by the autologous transplantation of endometrial tissue. A total of 36 model rats were randomly divided into three groups. The rats in Group 1 (control group, n=12) received no medication. The rats in Group 2 (n=12) and Group 3 (n=12) were administered 35 mg/m2 CDDP and 70 mg/m2 CDDP, respectively, every four days...
October 2018: Oncology Letters
Marie-Madeleine Dolmans, Diego D Manavella
BACKGROUND: Most cancer treatments like chemotherapy, radiotherapy or a combination of both are highly toxic to the gonads, putting girls and young women at risk of premature ovarian insufficiency and subsequent infertility. Non-oncological conditions may also require therapies that put women's reproductive potential at risk. Fertility preservation counseling should therefore be offered to all patients requiring gonadotoxic treatments, and to those who wish to postpone motherhood for social/personal reasons...
September 23, 2018: Journal of Obstetrics and Gynaecology Research
Lydia H Pecker, Jacqueline Y Maher, Jennie Y Law, Mary Catherine Beach, Sophie Lanzkron, Mindy S Christianson
OBJECTIVE: To highlight the risk of complications among women with sickle cell anemia (SCA) receiving fertility preservation treatment (FPT) before hematopoietic stem cell transplant (HSCT). DESIGN: Single-center case series. SETTING: Academic fertility center. PATIENT(S): Women aged 15-32 years with SCA undergoing FPT before HSCT. INTERVENTION(S): Retrospective, systematic review. MAIN OUTCOME MEASURE(S): FPT modality, SCA complications during FPT...
September 2018: Fertility and Sterility
Yodo Sugishita, Naoki Okamoto, Atsushi Uekawa, Takayuki Yamochi, Mariko Nakajima, Chie Namba, Suguru Igarashi, Takumi Sato, Sei Ohta, Makoto Takenoshita, Shu Hashimoto, Akiko Tozawa, Yoshiharu Morimoto, Nao Suzuki
PURPOSE: A device for closed vitrification was designed to reduce the risk of contamination and investigated on its efficacy for ovarian function recovery after cryopreservation and heterotopic transplantation. METHODS: Ovarian tissues from green fluorescence protein transgenic mice (10 GFP mice) were vitrified using the device, and warmed ovarian tissues were transplanted into the ovarian bursa region in wild-type female mice (6 mice). Fresh ovarian tissues were similarly transplanted as a control...
September 1, 2018: Journal of Assisted Reproduction and Genetics
F Fabregues, J Ferreri, J M Calafell, V Moreno, A Borrás, D Manau, F Carmona
BACKGROUND: The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to review the pertinent literature. METHODS: We present a case in wich a 32 - years old patient with POI became pregnant after IVA without tissue culture and with ovarian tissue transplantation. We also reviewed the literature using Pubmed database. CASE PRESENTATION: Pretreatment with estradiol/progesterone stopped the day before surgery...
August 31, 2018: Journal of Ovarian Research
Senta Hutter, Wouter T van Haaften, Anouk Hünerwadel, Katharina Baebler, Neel Herfarth, Tina Raselli, Céline Mamie, Benjamin Misselwitz, Gerhard Rogler, Bruce Weder, Gerard Dijkstra, Chantal Florence Meier, Cheryl de Vallière, Achim Weber, Pedro H Imenez Silva, Carsten A Wagner, Isabelle Frey-Wagner, Pedro A Ruiz, Martin Hausmann
Background and aims: pH-sensing ovarian cancer G-protein coupled receptor-1 (OGR1/GPR68) is regulated by key inflammatory cytokines. Patients suffering from inflammatory bowel diseases (IBD) express increased mucosal levels of OGR1 compared to non-IBD controls. pH-sensing may be relevant for progression of fibrosis, as extra-cellular acidification leads to fibroblast activation and extracellular matrix remodeling. We aimed to determine OGR1 expression in fibrotic lesions in the intestine of Crohn's disease (CD) patients, and the effect of Ogr1 deficiency in fibrogenesis...
August 25, 2018: Journal of Crohn's & Colitis
Roman Chmel, Marta Novackova, Libor Janousek, Jan Matecha, Zlatko Pastor, Jana Maluskova, Milos Cekal, Jakub Kristek, Michael Olausson, Jiri Fronek
While uterus transplantation is still in the experimental stage, it has promising potential as a treatment for women with absolute uterine factor infertility based on the childbirths from living donor trials conducted in Sweden and the United States. We report the main characteristics and perioperative and postoperative courses of both recipients and donors following four deceased donor and five living donor uterus transplantations. Three main priorities differentiate this study from the previously reported uterus transplantations...
August 27, 2018: American Journal of Transplantation
Jaewang Lee, Eun Jung Kim, Hyun Sun Kong, Hye Won Youm, Seul Ki Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
In vitro follicle growth (IVFG) is an emerging alternative option for fertility preservation in women instead of ovarian tissue cryopreservation and transplantation. To widen the application of this technique, follicle cryopreservation should be established prior to clinical use. In the present study, we tried to determine the optimal vitrification protocol of mouse ovarian follicle for in vitro culture and oocyte maturation by comparing four different compositions of cryoprotective agents (CPA). Secondary follicles were mechanically isolated from 2-week-old BDF-1 mice and randomly assigned to fresh control and four different groups by the composition of CPAs (ES, EDS, EFS and EPS groups; E: ethylene glycol, D: dimethyl sulfoxide, S: sucrose, F: ficoll, P: 1,2-propanediol (PROH))...
November 2018: Theriogenology
Luã Barbalho de Macêdo, Muriel Magda Lustosa Pimentel, Fernanda Araujo Dos Santos, Marcelo Barbosa Bezerra, Fernando Vagner Lobo Ladd, Carlos Eduardo Bezerra de Moura
The objective of this study was to evaluate effects of eCG on vascularization and development of feline ovarian tissue xenografted to immunosuppressed mice. Feline ovarian fragments (∼1 mm3 ) were transplanted under the renal capsule of 20 adult, ovariectomized, C57BL/6 SCID female mice. At 45 d after transplantation, 10 mice (controls) were euthanized and the remainder given 10 IU of eCG (and sacrificed 48 h later). Transplants were recovered immediately after death, fixed, sectioned, and stained with periodic acid-Schiff (PAS)...
November 2018: Theriogenology
Xiangyan Ruan
In order to promote the standard application of ovarian tissue cryopreservation in China, and to provide effective scientific medical services of fertility preservation for patients, the First Chinese Guideline of Ovarian Tissue Cryopreservation and Transplantation is established according to the agreements between gynecologists, embryologists, oncologists, pediatricians, breast oncologists, hematologists, and experts on Traditional Chinese Medicine (TCM), based on already successful treated cases within Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China, and based on already existing international guidelines on fertility preservation including important publications in this field...
August 21, 2018: Gynecological Endocrinology
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