keyword
MENU ▼
Read by QxMD icon Read
search

Ovarian transplantation

keyword
https://www.readbyqxmd.com/read/30112413/fertility-preservation-current-and-future-perspectives-for-oncologic-patients-at-risk-for-iatrogenic-premature-ovarian-insufficiency
#1
REVIEW
Sara Pinelli, Stefano Basile
Progress in recent years in the efficacy of oncologic treatment and early diagnosis of cancer has determined an increase in life expectance in cancer patients. About 10% of all cancer cases affect women younger than 45 years; therefore nowadays approximately 5-6% of the population in childbearing age consists in cancer survivors. A crucial issue is the high risk of premature ovarian insufficiency due to possible gonadotoxic effects of oncologic treatments. Considering combined chemotherapy, radiation therapy, and bone marrow transplantation, this risk can reach 92-100%, depending on the age and ovarian reserve of the patient, as well as the schedule and type of therapy...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30092819/exosomes-derived-from-human-adipose-mesenchymal-stem-cells-improve-ovary-function-of-premature-ovarian-insufficiency-by-targeting-smad
#2
Boxian Huang, Jiafeng Lu, Chenyue Ding, Qinyan Zou, Wei Wang, Hong Li
BACKGROUND: Although many reports show that various kinds of stem cells have the ability to recover the function of premature ovarian insufficiency (POI), few studies are associated with the mechanism of stem cell treatment of POI. We designed this experimental study to investigate whether human adipose stem cell-derived exosomes (hADSC-Exos) retain the ability to restore ovarian function and how hADSC-Exos work in this process. METHODS: A POI mouse model was established and human ovarian granule cells (hGCs) collected from individuals with POI were prepared to assess the therapeutic effects and illuminate the mechanism of hADSCs in curing POI...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30059567/role-of-autophagy-in-ovarian-cryopreservation-by-vitrification
#3
Y Xian, B Li, P Pan, Y Wang, X Pei, Y Yang
BACKGROUND: Ovarian cryopreservation by vitrification and transplantation are useful methods to recover female fertility after radiotherapy and chemotherapy. As type II programmed cell death, autophagy plays important roles in ovarian follicle development, ovarian follicle atresia and anti-stress injury. OBJECTIVE: The potential role of autophagy in ovarian vitrification was investigated. MATERIALS AND METHODS: Mouse ovaries were cryopreserved by vitrification, and autophagy was treated, after which the ovarian histology was checked, and ovarian follicles were counted...
May 2018: Cryo Letters
https://www.readbyqxmd.com/read/30058682/functional-role-of-sirt1-induced-hmgb1-expression-and-acetylation-in-migration-invasion-and-angiogenesis-of-ovarian-cancer
#4
W Jiang, P Jiang, R Yang, D-F Liu
OBJECTIVE: Ovarian cancer is a commonly occurred tumor in females. High motility group box-1 protein (HHMB1) is a chromosome-related protein with multiple functions. A recent study revealed critical roles of HMGB1 in occurrence and progression of ovarian cancer. Sirtuin 1 (SIRT1) is a recently identified novel molecule, which regulates acetylation of HMGB1. Whether SIRT1 is involved in migration, invasion or angiogenesis of ovarian cancer is unclear. This study aims to investigate the role of SIRT1-induced HMGB1 acetylation in migration, invasion, and angiogenesis in ovarian cancer...
July 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30045213/acog-committee-opinion-no-747-gynecologic-issues-in-children-and-adolescent-cancer-patients-and-survivors
#5
(no author information available yet)
The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexuality; contraception; ovarian function, including fertility preservation; breast and cervical cancer screening; hormone therapy; and graft-versus-host disease...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30045207/acog-committee-opinion-no-747-summary-gynecologic-issues-in-children-and-adolescent-cancer-patients-and-survivors
#6
(no author information available yet)
The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexuality; contraception; ovarian function, including fertility preservation; breast and cervical cancer screening; hormone therapy; and graft-versus-host disease...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30043336/xenotransplantation-of-pre-pubertal-ovarian-cortex-and-prevention-of-follicle-depletion-with-anti-m%C3%A3-llerian-hormone-amh
#7
Laura Detti, Nicole M Fletcher, Ghassan M Saed, Trevor W Sweatman, Rebecca A Uhlmann, Alberto Pappo, Irene Peregrin-Alvarez
OBJECTIVE: To determine whether recombinant AMH (rAMH) could prevent post-transplant follicular depletion by acting on the stemness markers Oct-4, Sox2, and NANOG. MATERIALS AND METHODS: This was an experimental study where 12 ovariectomized nude mice were xenotransplanted with vitrified/warmed ovarian cortex obtained from a pre-pubertal girl and Alzet pumps delivering rAMH, or placebo (control), were inserted intra-abdominally. Previously vitrified/warmed ovarian cortex fragments were transplanted after 7 days and then harvested after 14 days from pump placement...
July 25, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30039911/ovarian-sertoli-leydig-tumor-after-bone-marrow-transplant-for-sickle-cell-disease
#8
Lia Neu Phillips, Lakshmanan Krishnamurti, Heather Rytting, Thomas A Olson
As bone marrow transplant for sickle cell disease becomes increasingly common, long-term outcomes including secondary malignancies are beginning to be described. Here, we report a case of ovarian Sertoli-Leydig tumor that occurred after allogeneic bone marrow transplant for sickle cell disease.
July 24, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30031170/selective-anti-tumor-activity-of-wogonin-targeting-the-warburg-effect-through-stablizing-p53
#9
Yikai Zhao, Lulu Zhang, Yifan Wu, Qinsheng Dai, Yuxin Zhou, Zhiyu Li, Lin Yang, Qinglong Guo, Na Lu
Most cancer cells generate energy through aerobic glycolysis to enable their rapid growth and proliferation, which is a phenomenon known as Warburg effect. Inhibition of aerobic glycolysis reduces lactate and ATP generation in cancer cells, and ultimately kills tumor cells. Increasing evidence suggests that wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro. However, the role of wogonin in the aerobic glycolysis of tumor cells has not yet been elucidated...
July 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30018898/fertility-preservation-for-adolescent-and-young-adult-cancer-patients-in-japan
#10
REVIEW
Yodo Sugishita, Nao Suzuki
Adolescent and young adult (AYA) patients are generally defined as being from 15 to 39 years old. For preservation of fertility in AYA cancer patients, the best-known guideline in this field was released by the American Society of Clinical Oncology (ASCO) in 2006. However, the ASCO guideline is not necessarily applicable to Japanese cancer patients. The Japan Society for Fertility Preservation (JSFP) was formed in 2012, and a system and guideline for fertility preservation in Japanese AYA cancer patients plus children was released in July 2017...
July 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/30018897/ovarian-tissue-cryopreservation-and-transplantation-in-patients-with-cancer
#11
REVIEW
Sooyoung Kim, Younji Lee, Sanghoon Lee, Tak Kim
Chemotherapy and radiotherapy improved survival rates of patients with cancer. However, they can cause ovarian failure and infertility in women of reproductive age. Infertility following cancer treatment is considered a major quality of life issue. Ovarian tissue cryopreservation and transplantation is an important option for fertility preservation in adult patients with cancer who need immediate chemotherapy or do not want to undergo ovarian stimulation. Ovarian tissue freezing is the only option for preserving the fertility of prepubertal patients with cancer...
July 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/30017605/robot-assisted-laparoscopic-transplant-to-native-ureteroureterostomy-of-an-intraperitoneal-renal-allograft
#12
Belinda Li, Dennis B Liu, Edward M Gong
OBJECTIVE: The objective is to describe our experience with robot-assisted laparoscopic transplant-to-native ureteroureterostomy (UU) in a pediatric patient with an intraperitoneal renal allograft. We have previously demonstrated this technique for an extraperitoneal allograft. METHODS: The patient is a 17-year-old female who had undergone a deceased donor renal transplant at 5 years of age. She developed acute kidney injury and hydronephrosis because of a ureteral stricture that developed after a right ovarian cyst excision...
June 30, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30015147/an-optimized-controlled-rate-slow-cooling-protocol-for-bovine-ovarian-tissue-cryopreservation-by-means-of-x-ray-computed-tomography
#13
Ariadna Corral, Marcin Balcerzyk, Miguel Gallardo, Christiani A Amorim, Ángel Parrado-Gallego, Ramón Risco
Cryopreservation and subsequent transplantation of ovarian tissue is the only option to preserve fertility in certain patients facing gonadotoxic treatment. So far, cryopreservation of ovarian tissue has been carried out mostly by a controlled rate slow cooling process, typically known as slow freezing. Even though there are still some concerns about the iatrogenic damage on the follicle population, this technique has been used in the more than 100 live births reported to date. It is well known that the control of the cryoprotectant loading in the tissue is crucial to in a cryopreservation procedure...
July 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/30003329/gdf9-%C3%AE-promotes-folliculogenesis-in-sheep-ovarian-transplantation-onto-the-chick-embryo-chorioallantoic-membrane-cam-in-cryopreservation-programs
#14
Mahboubeh Vatanparast, Mohammad Ali Khalili, Nahid Yari, Bryan Woodward, Mehdi Mohsenzadeh
PURPOSE: Ovarian tissue (OT) cryopreservation is a treatment option for fertility preservation among young cancer patients. However, the procedure may involve a reduction in the GDF9-β expression and a delay in follicular growth after thawing and transplantation. The aim of this study was to evaluate whether supplementation of GDF9-β can compensate the reduction of this factor during the cryopresevation process and promote folliculogenesis after transplantation of thawed sheep ovarian tissue...
July 12, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/30002647/cryopreservation-of-ovarian-tissue-opportunities-beyond-fertility-preservation-and-a-positive-view-into-the-future
#15
REVIEW
Stine G Kristensen, Claus Y Andersen
In current years, ovarian tissue cryopreservation (OTC) and transplantation is gaining ground as a successful method of preserving fertility in young women with primarily cancer diseases, hereby giving them a chance of becoming biological mothers later on. However, OTC preserves more than just the reproductive potential; it restores the ovarian endocrine function and thus the entire female reproductive cycle with natural levels of essential hormones. In a female population with an increased prevalence in the loss of ovarian function due to induced primary ovarian insufficiency (POI) and aging, there is now, a need to develop new treatments and provide new opportunities to utilize the enormous surplus of follicles that most females are born with and overcome major health issues associated with the lack of ovarian hormones...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29999288/update-on-oogenesis-in-vitro
#16
Raffaella Fabbri, Chiara Zamboni, Rossella Vicenti, Maria Macciocca, Roberto Paradisi, Renato Seracchioli
INTRODUCTION: Ovarian tissue is increasingly being collected from cancer patients and cryopreserved for fertility preservation. Alternately to the autologous transplantation, the development of culture systems that support oocyte development from the primordial follicle stage represent a valid strategy to restore fertility. The aim of this study is to review the most recent data regarding oogenesis in vitro and to provide an up-to-date on the contemporary knowledge of follicle growth and development in vitro...
July 10, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29998469/effect-of-sustained-release-of-basic-fibroblast-growth-factor-using-biodegradable-gelatin-hydrogels-on-frozen-thawed-human-ovarian-tissue-in-a-xenograft-model
#17
Ayaka Tanaka, Hitomi Nakamura, Yasuhiko Tabata, Yuka Fujimori, Keiichi Kumasawa, Tadashi Kimura
AIM: Ovarian tissue cryopreservation before cancer treatment is the only option to preserve fertility under some circumstances. However, tissue ischemia after transplantation while awaiting angiogenesis induces dysfunctional folliculogenesis and reduces ovarian reserve and is one of the disadvantages of frozen-thawed ovarian tissue transplantation. Basic fibroblast growth factor (bFGF) is a major regulator of angiogenesis. However, bFGF rapidly loses biological activity when its free form is injected in vivo...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29986747/establishment-and-molecular-characterization-of-a-human-ovarian-clear-cell-carcinoma-cell-line-fdov1
#18
Wei Jiang, Shuang Ye, Libing Xiang, Wentao Yang, Tiancong He, Xuan Pei, Lin Guo, Huijuan Yang
BACKGROUND: Ovarian clear cell carcinoma is a distinct histologic subtype with grave survival. The underlying molecular mechanism is not fully elucidated. However, we don't have many cell lines, which are useful experimental tools for research. We describe the establishment and characterization of a new ovarian clear cell carcinoma cell line from a Chinese patient. RESULTS: FDOV1 has been subcultured for more than 80 generations. Monolayer cultured cells are polygonal in shape, showing a transparent cytoplasm full of vacuoles...
July 9, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29960702/in-vivo-characterization-of-metabolic-activity-and-oxidative-stress-in-grafted-human-ovarian-tissue-using-microdialysis
#19
Luciana Cacciottola, Diego Daniel Manavella, Christiani Andrade Amorim, Jacques Donnez, Marie-Madeleine Dolmans
OBJECTIVE: To characterize oxidative stress and metabolic activity in xenografted human ovarian tissue using microdialysis. DESIGN: Prospective experimental study. SETTING: Gynecology research unit at a university hospital. PATIENT(S): Cryopreserved ovarian cortex from five women 27-35 years of age. INTERVENTION(S): Frozen-thawed human ovarian tissue fragments were xenografted to the back muscle of ten nude mice...
June 27, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29960701/autologous-stem-cell-ovarian-transplantation-to-increase-reproductive-potential-in-patients-who-are-poor-responders
#20
Sonia Herraiz, Mónica Romeu, Anna Buigues, Susana Martínez, César Díaz-García, Inés Gómez-Seguí, José Martínez, Nuria Pellicer, Antonio Pellicer
OBJECTIVE: To evaluate effects of autologous stem cell ovarian transplant (ASCOT) on ovarian reserve and IVF outcomes of women who are poor responders with very poor prognosis. DESIGN: Prospective observational pilot study. SETTING: University hospital. PATIENT(S): Seventeen women who are poor responders. INTERVENTION(S): Ovarian infusion of bone marrow-derived stem cells. MAIN OUTCOME MEASURE(S): Serum antimüllerian hormone levels and antral follicular count (AFC), punctured follicles, and oocytes retrieved after stimulation (controlled ovarian stimulation) were measred...
June 27, 2018: Fertility and Sterility
keyword
keyword
171519
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"