keyword
https://read.qxmd.com/read/38195073/efficacy-and-safety-of-parp-inhibitor-in-non-small-cell-lung-cancer-a-systematic-review-with-meta-analysis
#1
JOURNAL ARTICLE
Alejandro Olivares-Hernández, Jonnathan Roldán-Ruiz, José Pablo Miramontes-González, Irene Toribio-García, Juan Luis García-Hernández, Luis Posado-Domínguez, Lorena Bellido-Hernández, Juan Jesús Cruz-Hernández, Emilio Fonseca-Sánchez, Edel Del Barco-Morillo
BACKGROUND: Non-small cell lung cancer (NSCLC) has undergone a major change in the last decade in terms of survival and prognosis due to the introduction of new drugs in the last 10 years. One of the drugs with the most promising preliminary results in NSCLC are PARP inhibitors (iPARPs), whose clinical trials have very heterogeneous results. The use of iPARPs in NSCLC may lead to increased survival in several selected patients, and their use may become a standard in the coming years. However, there is currently controversy about the efficacy and safety of these drugs in NSCLC...
December 2023: Chinese Clinical Oncology
https://read.qxmd.com/read/37122963/the-relationship-between-parp-inhibitors-with-the-relapse-and-leukemisation-of-lymphomas-a-case-report
#2
Marta Navalón-Jiménez, Alejandro Olivares-Hernández, Luis Figuero-Pérez, José Pablo Miramontes-González, Enrique Montero-Mateos, Juan Jesús Cruz-Hernández, Emilio Fonseca-Sánchez
BACKGROUND: Nowadays the poly-ADP ribose polymerase inhibitors (iPARPs) are the mainly treatment for the ovarian cancer and other solid tumours. However, given its recent use, long-term toxicity is still under study. The occurrence of acute leukaemias and myelodysplastic syndromes (MDS) secondarily to iPARPs is known (0.5-1%). CASE DESCRIPTION: We present the case of a 78-year-old patient with a serous carcinoma of ovary in maintenance treatment with Niraparib after response to platinum...
2023: AME Case Reports
https://read.qxmd.com/read/30103829/brca1-and-brca2-mutations-and-clinical-interpretation-in-398-ovarian-cancer-patients-comparison-with-breast-cancer-variants-in-a-similar-population
#3
JOURNAL ARTICLE
Florencia C Cardoso, Susana Goncalves, Pablo G Mele, Natalia C Liria, Leonardo Sganga, Ignacio Diaz Perez, Ernesto J Podesta, Angela R Solano
BACKGROUND: Ovarian cancer is the leading cause of death worldwide among gynecologic malignancies. The recent approval of inhibitors of poly (ADP-ribose) polymerase (iPARP) in the treatment of ovarian cancer in the presence of a BRCA1/2 mutation has sparked the analysis of women with such diagnosis, which can further benefit from the detection of carriers in the family. Germline sequence and large rearrangements for BRCA1/2 were tested in 398 consecutive epithelial ovarian cancer (EOC) patients...
August 13, 2018: Human Genomics
https://read.qxmd.com/read/22450359/-parp-inhibitors-and-breast-cancer-update-and-perspectives
#4
REVIEW
Anthony Gonçalves
Poly(ADP-ribose) polymerase (PARP) family has become a promising therapeutic target in various malignancies including breast cancer. When homologous recombination repair is deficient, as it is observed in BRCA1/2-mutated tumor models, inhibition of PARP was shown to induce massive and selective tumor cell death (the so-called "synthetic lethality"). In breast cancer, PARP inhibitors have been developed as single-agent in BRCA1/2-mutated tumors or in combination with chemotherapy. Recently, a randomized phase III clinical trial failed to demonstrate any survival improvement by combining the iPARP iniparib to chemotherapy in triple-negative metastatic breast cancer patients...
April 1, 2012: Bulletin du Cancer
1
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.