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https://www.readbyqxmd.com/read/30063840/telemonitoring-in-asthma-control-a-randomized-controlled-trial
#1
Tiva Nemanic, Irena Sarc, Sabina Skrgat, Matjaz Flezar, Iztok Cukjati, Mateja Marc Malovrh
OBJECTIVE: Telemonitoring seems to be a useful tool for patients' management. The aim of our project was to test the applicability and potential effects of a 12-months telemonitoring of patients with asthma supported by information and communication technologies. METHODS: We included 100 patients with asthma followed in the outpatient pulmonary clinic in a randomized controlled clinical trial. The patients' data was collected by study questionnaires and lung function tests at the inclusion and at the end of interventional period...
July 31, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/30059033/methods-for-detecting-cytotoxic-amyloids-following-infection-of-pulmonary-endothelial-cells-by-pseudomonas-aeruginosa
#2
Ron Balczon, Michael Francis, Silas Leavesley, Troy Stevens
Patients who survive pneumonia have elevated death rates in the months following hospital discharge. It has been hypothesized that infection of pulmonary tissue during pneumonia results in the production of long-lived cytotoxins that can lead to subsequent end organ failure. We have developed in vitro assays to test the hypothesis that cytotoxins are produced during pulmonary infection. Isolated rat pulmonary endothelial cells and the bacterium Pseudomonas aeruginosa are used as model systems, and the production of cytoxins following infection of the endothelial cells by the bacteria is demonstrated using cell culture followed by direct quantitation using lactate dehydrogenase assays and a novel microscopic method utilizing ImageJ technology...
July 12, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30015679/imaging-biomarkers-and-staging-in-ipf
#3
Simon L F Walsh
PURPOSE OF REVIEW: The application of computer-based imaging analysis in patients with idiopathic pulmonary fibrosis is a rapidly developing field. The purpose of this review is to provide insights into the problems associated with visual interpretation of HRCT patterns and describe some of the current technologies used to provide objective quantification of disease on HRCT. Future directions are also discussed. RECENT FINDINGS: Although there is strong evidence that visual quantification of disease on HRCT in idiopathic pulmonary fibrosis provides prognostic information, this approach is hampered by its subjective nature and interobserver variability...
September 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/30012527/a-randomized-comparison-of-radiation-therapy-techniques-in-the-management-of-node-positive-breast-cancer-primary-outcomes-analysis
#4
Reshma Jagsi, Kent A Griffith, Jean M Moran, Edward Ficaro, Robin Marsh, Robert T Dess, Eugene Chung, Adam L Liss, James A Hayman, Charles S Mayo, Kevin Flaherty, James Corbett, Lori Pierce
PURPOSE: Although inverse-planned intensity modulated radiotherapy (IMRT) and deep inspiration breath hold (DIBH) may allow for more conformal dose distributions, it is unknown whether using these technologies reduces cardiac or pulmonary toxicity of breast radiotherapy. METHODS AND MATERIALS: A randomized controlled trial compared IMRT-DIBH versus standard, free-breathing, forward-planned, three-dimensional conformal radiotherapy in patients with left-sided, node-positive breast cancer in whom the internal mammary nodal region was targeted...
August 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29983599/review-of-lung-sealant-technologies-for-lung-volume-reduction-in-pulmonary-disease
#5
REVIEW
Branislava Milenkovic, Sanja Dimic Janjic, Spasoje Popevic
Emphysema is an incurable and underdiagnosed disease with obstructive ventilatory impairment of lung function. Despite decades of research, medical treatments available so far did not significantly improve the survival benefits. Different bronchoscopic methods for lung volume reduction (LVR) in emphysema were used in the past 2 decades aiming to close the airways serving the hyperinflated lung regions and to allow the gas in the more distal bullas to be absorbed. Sealants and adhesives can be natural/biological, synthetic and semisynthetic...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29938972/current-aspects-in-sepsis-approach-turning-things-around
#6
REVIEW
F J Candel, M Borges Sá, S Belda, G Bou, J L Del Pozo, O Estrada, R Ferrer, J González Del Castillo, A Julián-Jiménez, I Martín-Loeches, E Maseda, M Matesanz, P Ramírez, J T Ramos, J Rello, B Suberviola, A Suárez de la Rica, P Vidal
The incidence and prevalence of sepsis depend on the definitions and records that we use and we may be underestimating their impact. Up to 60% of the cases come from the community and in 30-60% we obtain microbiological information. Sometimes its presentation is ambiguous and there may be a delay in its detection, especially in the fragile population. Procalcitonin is the most validated biomarker for bacterial sepsis and the one that best discriminates the non-infectious cause. Presepsin and pro-adrenomedullin are useful for early diagnosis, risk stratification and prognosis in septic patients...
August 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29903487/improved-lung-nodule-diagnosis-accuracy-using-lung-ct-images-with-uncertain-class
#7
Zhiqiong Wang, Junchang Xin, Peishun Sun, Zhixiang Lin, Yudong Yao, Xiaosong Gao
BACKGROUND AND OBJECTIVE: Among all malignant tumors, lung cancer ranks in the top in mortality rate. Pulmonary nodule is the early manifestation of lung cancer, and plays an important role in its discovery, diagnosis and treatment. The technology of medical imaging has encountered a rapid development in recent years, thus the amount of pulmonary nodules can be discovered are on the raise, which means even tiny or minor changes in lung can be recorded by the CT images. This paper proposes a pulmonary nodule computer aided diagnosis (CAD) based on semi-supervised extreme learning machine(SS-ELM)...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29878283/preoperative-assessment-in-pulmonary-resection-surgery
#8
Nozha Ben Salah, Dorra Bejar, Houda Snene, Yacine Ouahchi, Nadia Mehiri, Bechir Louzir
Pulmonary resection can be associated with a significant risk of morbidity and mortality, which depends on the nature and extent of pulmonary resection but also on the patient himself. This risk can be apprehended by a preoperative assessment which estimates the immediate operative risk as well as the physiological state and the post-operative quality of life which can require more conservative therapies. Currently, preoperative exploration of a patient is based on various technological tools, which can range from simple electrocardiogram or simple spirometry to a complex exploration such as a cardiorespiratory effort test...
December 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29869625/microrna-708-3p-as-a-potential-therapeutic-target-via-the-adam17-gata-stat3-axis-in-idiopathic-pulmonary-fibrosis
#9
Bo Liu, Rongrong Li, Jinjin Zhang, Chao Meng, Jie Zhang, Xiaodong Song, Changjun Lv
MicroRNAs (miRNAs) are important diagnostic markers and therapeutic targets for many diseases. However, the miRNAs that control the pathogenesis of idiopathic pulmonary fibrosis (IPF) and act as potential therapeutic targets for the disease are rarely studied. In the present study, we analyzed the function and regulatory mechanism of microRNA-708-3p (miR-708-3p) and evaluated this marker's potential as a therapeutic target in IPF. The clinical and biological relevance of fibrogenesis for miR-708-3p was assessed in vivo and in vitro, specifically in matching plasma and tissue samples from 78 patients with IPF...
March 30, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29861632/airspace-dimension-assessment-with-nanoparticles-reflects-lung-density-as-quantified-by-mri
#10
H Laura Aaltonen, Simon S Kindvall, Jonas K Jakobsson, Jakob Löndahl, Lars E Olsson, Sandra Diaz, Sophia Zackrisson, Per Wollmer
Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29790581/the-pharmacokinetics-pharmacodynamics-and-tolerability-of-pur0200-a-novel-tiotropium-formulation-in-chronic-obstructive-pulmonary-disease
#11
Dave Singh, Arjun Ravi, Katie Kane, Tess Schmalbach, David L Hava
AIMS: PUR0200 is a tiotropium bromide formulation engineered with the iSPERSE dry powder delivery technology. PUR0200 is being developed as a bioequivalent alternative to tiotropium bromide, delivered using Spiriva® HandiHaler® (HH). We investigated the bronchodilator effects, pharmacokinetics and safety of PUR0200 in patients with chronic obstructive pulmonary disease (COPD). METHODS: This was a randomized, placebo-controlled, crossover study using different PUR0200 doses and the comparator tiotropium HH...
May 23, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29788482/a-telehealth-system-for-automated-diagnosis-of-asthma-and-chronical-obstructive-pulmonary-disease
#12
Lejla Gurbeta, Almir Badnjevic, Mirjana Maksimovic, Enisa Omanovic-Miklicanin, Ervin Sejdic
This paper presents the development and real-time testing of an automated expert diagnostic telehealth system for the diagnosis of 2 respiratory diseases, asthma and Chronic Obstructive Pulmonary Disease (COPD). The system utilizes Android, Java, MATLAB, and PHP technologies and consists of a spirometer, mobile application, and expert diagnostic system. To evaluate the effectiveness of the system, a prospective study was carried out in 3 remote primary healthcare institutions, and one hospital in Bosnia and Herzegovina healthcare system...
May 18, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29779393/a-new-method-for-visualizing-pulmonary-artery-microvasculature-using-synchrotron-radiation-pulmonary-microangiography-the-measurement-of-pulmonary-arterial-blood-flow-velocity-in-the-high-pulmonary-blood-flow-rat-model
#13
Chiho Tokunaga, Shonosuke Matsushita, Hiroaki Sakamoto, Kazuyuki Hyodo, Misao Kubota, Kenkichi Tanioka, Yuji Hiramatsu
Background Increased pulmonary blood flow (PBF) and shear stress may provoke irreversible vascular remodeling, yet invasive visualization of the microvasculature complicates monitoring. A non-invasive imaging methodology would therefore safely provide mechanistic insights into the progression of high PBF-induced vascular remodeling. Purpose To establish a novel microvasculature visualization method using synchrotron radiation pulmonary microangiography (SRPA) that can also calculate PBF velocity in vivo. Material and Methods A high PBF rat model was established by making a fistula between the abdominal aorta and inferior vena cava...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29755982/clinical-genetics-in-interstitial-lung-disease
#14
REVIEW
Chad A Newton, Philip L Molyneaux, Justin M Oldham
Interstitial lung disease (ILD) comprises a heterogeneous group of diffuse parenchymal lung processes with overlapping clinical, radiographic, and histopathologic features. Among the most common and deadly ILDs are idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP). As the name implies, the cause of IPF remains elusive, but a variety of genetic and infectious risk factors have been identified. CHP results from chronic inhalation of an organic antigen, usually of avian or mold origin, and may occur in patients with a genetic predisposition...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29747662/progressive-mobility-program-and-technology-to-increase-the-level-of-physical-activity-and-its-benefits-in-respiratory-muscular-system-and-functionality-of-icu-patients-study-protocol-for-a-randomized-controlled-trial
#15
Debora Stripari Schujmann, Adriana Claudia Lunardi, Carolina Fu
BACKGROUND: Enhanced mobility in the Intensive Care Unit (ICU) could minimize the negative effects of critical illness, such as declines in cognitive, muscular, respiratory, and functional capacity. We aim to compare the functional status at ICU discharge of patients who underwent a progressive mobilization protocol versus patients who received conventional physiotherapy. We also examine the level of physical activity in the ICU, the degree of pulmonary and muscle function, and the length of stay to analyze correlations between these variables...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29743347/computational-modeling-guides-tissue-engineered-heart-valve-design-for-long-term-in-vivo-performance-in-a-translational-sheep-model
#16
Maximilian Y Emmert, Boris A Schmitt, Sandra Loerakker, Bart Sanders, Hendrik Spriestersbach, Emanuela S Fioretta, Leon Bruder, Kerstin Brakmann, Sarah E Motta, Valentina Lintas, Petra E Dijkman, Laura Frese, Felix Berger, Frank P T Baaijens, Simon P Hoerstrup
Valvular heart disease is a major cause of morbidity and mortality worldwide. Current heart valve prostheses have considerable clinical limitations due to their artificial, nonliving nature without regenerative capacity. To overcome these limitations, heart valve tissue engineering (TE) aiming to develop living, native-like heart valves with self-repair, remodeling, and regeneration capacity has been suggested as next-generation technology. A major roadblock to clinically relevant, safe, and robust TE solutions has been the high complexity and variability inherent to bioengineering approaches that rely on cell-driven tissue remodeling...
May 9, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29686661/molecular-imaging-of-invasive-pulmonary-aspergillosis-using-immunopet-mri-the-future-looks-bright
#17
REVIEW
Christopher R Thornton
Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mold Aspergillus . Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision making, and so is used in many hematology units to drive antifungal treatment...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29675789/experimental-platform-utilising-melting-curve-technology-for-detection-of-mutations-in-mycobacterium-tuberculosis-isolates
#18
Agnieszka Broda, Vlad Nikolayevskyy, Nicki Casali, Huma Khan, Richard Bowker, Gemma Blackwell, Bhakti Patel, James Hume, Waqar Hussain, Francis Drobniewski
Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB...
July 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29670881/impact-of-transcriptomics-on-our-understanding-of-pulmonary-fibrosis
#19
REVIEW
Milica Vukmirovic, Naftali Kaminski
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung resident cells. The introduction of transcriptomics, genome scale profiling of thousands of RNA transcripts, caused a significant inversion in IPF research. Instead of generating hypotheses based on animal models of disease, or biological plausibility, with limited validation in humans, investigators were able to generate hypotheses based on unbiased molecular analysis of human samples and then use animal models of disease to test their hypotheses...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29650248/prevalence-and-risk-factors-of-chronic-obstructive-pulmonary-disease-in-china-the-china-pulmonary-health-cph-study-a-national-cross-sectional-study
#20
Chen Wang, Jianying Xu, Lan Yang, Yongjian Xu, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Wanzhen Yao, Tieying Sun, Guangliang Shan, Ting Yang, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Jianping Zhao, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Ting Yang, Yahong Chen, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Chung-Shiuan Chen, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Bin Cao, Huaping Dai, Lirong Liang, Jiang He
BACKGROUND: Although exposure to cigarette smoking and air pollution is common, the current prevalence of chronic obstructive pulmonary disease (COPD) is unknown in the Chinese adult population. We conducted the China Pulmonary Health (CPH) study to assess the prevalence and risk factors of COPD in China. METHODS: The CPH study is a cross-sectional study in a nationally representative sample of adults aged 20 years or older from ten provinces, autonomous regions, and municipalities in mainland China...
April 28, 2018: Lancet
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