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Cardiopulmonary test prediction

Kristina Nadine Heye, Valentin Rousson, Walter Knirsch, Ingrid Beck, Rabia Liamlahi, Vera Bernet, Hitendu Dave, Beatrice Latal
OBJECTIVE: To determine growth and its relationship to IQ in children with congenital heart disease (CHD) undergoing cardiopulmonary bypass surgery within the first year of life. STUDY DESIGN: Prospective single-center cohort study on 143 children (91 males) with different types of CHD (29 univentricular). Children with recognized genetic disorders were excluded. Growth (weight, height, and head circumference [HC]) was assessed at birth, before surgery, and at 1, 4, and 6 years and compared with Swiss growth charts...
October 16, 2018: Journal of Pediatrics
Oliver M Barry, Kimberlee Gauvreau, Jonathan Rhodes, Jeffrey R Reichman, Laura Bourette, Tracy Curran, Julieann O'Neill, Jennifer L Pymm, Mark E Alexander
OBJECTIVES: This study quantified the incidence of arrhythmias during pediatric exercise stress tests (ESTs) and evaluated criteria to identify patients at risk of clinically important arrhythmias. BACKGROUND: The incidence of clinically important arrhythmias during pediatric ESTs and criteria for identifying high-risk patients are poorly characterized. METHODS: A retrospective review of ESTs performed from 2013 to 2015 was studied. Arrhythmias were categorized into 4 classes based on need for test termination and intervention...
October 2018: JACC. Clinical Electrophysiology
Eleni S Nakou, Maria E Marketou, Gregory I Chlouverakis, Alexandros P Patrianakos, Panos E Vardas, Fragiskos I Parthenakis
BACKGROUND: Despite robust data on the benefits of sacubitril/ valsartan (LCZ696) in patients with chronic heart failure with reduced ejection fraction (HFrEF), there is no evidence yet on prespecified predictive markers of its efficacy. HYPOTHESIS: The objective of this study was to identify potentially prognostic factors of LCZ696 treatment response. METHODS: We included 48 symptomatic patients with chronic HFrEF (LVEF ≤ 35%) and New York Heart Association (NYHA) class II/III: Group A (N =23) received LCZ696 (105 ± 30 mg twice daily), whereas it was not prescribed in group B (N = 25) according to physician's judgement...
October 15, 2018: Clinical Cardiology
Henric Nilsson, Eva Nylander, Sabina Borg, Éva Tamás, Kristofer Hedman
Aortic valve surgery is the definitive treatment for aortic stenosis (AS). No specific recommendation is available on how exercise training should be conducted and evaluated after aortic valve replacement (AVR). This study aimed to examine the effect of aerobic exercise training on exercise capacity following AVR. In addition to our primary outcome variable, peak oxygen uptake (peakVO2 ), the effect on submaximal cardiopulmonary variables including oxygen uptake kinetics (tau), oxygen uptake efficiency slope (OUES) and ventilatory efficiency (VE/VCO2 slope) was evaluated...
October 8, 2018: Clinical Physiology and Functional Imaging
So Mi Shin, Kyung Su Kim, Gil Joon Suh, Kyuseok Kim, Woon Yong Kwon, Jonghwan Shin, You Hwan Jo, Jae Hyuk Lee, Huijai Lee, Joonghee Kim, Yoon Sun Jung, Taegyun Kim, Kyoung Min You
AIM: Although various quantitative methods have been developed for predicting neurological prognosis in patients with out-of-hospital cardiac arrest (OHCA), they are too complex for use in clinical practice. We aimed to develop a simple decision rule for predicting neurological outcomes following the return of spontaneous circulation (ROSC) in patients with OHCA using fast-and-frugal tree (FFT) analysis. METHODS: We performed a retrospective analysis of prospectively collected data archived in a multi-centre registry...
October 4, 2018: Resuscitation
Vivien M Hsu, Lorinda Chung, Laura K Hummers, Ami Shah, Robert Simms, Marcy Bolster, Faye N Hant, Richard M Silver, Aryeh Fischer, Monique E Hinchcliff, John Varga, Avram Z Goldberg, Chris T Derk, Elena Schiopu, Dinesh Khanna, Lee S Shapiro, Robyn T Domsic, Thomas Medsger, Maureen D Mayes, Daniel Furst, Mary Ellen Csuka, Jerry A Molitor, Lesley Ann Saketkoo, Christian R Salazar, Virginia D Steen
OBJECTIVE: We sought to identify predictors of mortality and cardiopulmonary hospitalizations in patients at risk for pulmonary hypertension (PH) and enrolled in PHAROS, a prospective cohort study to investigate the natural history of PH in systemic sclerosis (SSc). METHODS: The at-risk population for PH was defined by the following entry criteria: echocardiogram systolic pulmonary arterial pressure > 40 mmHg, or DLCO < 55% predicted or ratio of % forced vital capacity/%DLCO > 1...
October 1, 2018: Journal of Rheumatology
Li-Jung Tseng, Hsi-Yu Yu, Chih-Hsien Wang, Nai-Hsin Chi, Shu-Chien Huang, Heng-Wen Chou, Hsin-Chin Shih, Nai-Kuan Chou, Yih-Sharng Chen
Extracorporeal cardiopulmonary resuscitation (ECPR) has gradually come to be regarded as an effective therapy, but the hospital mortality rate after ECPR is still high and unpredictable. The present study tested whether age-adjusted Charlson comorbidity index (ACCI) can be used as an objective selection criterion to ensure the most efficient utilization of medical resources. Adult patients (age ≥ 18 years) receiving ECPR at our institution between 2006 and 2015 were included. Data regarding ECPR events and ACCI characteristics were collected immediately after the extracorporeal membrane oxygenation (ECMO) setup...
September 29, 2018: Journal of Clinical Medicine
Ricardo Fontes-Carvalho, Francisco Sampaio, Madalena Teixeira, Catarina Ruivo, José Ribeiro, Ana Azevedo, Adelino Leite-Moreira, Vasco Gama Ribeiro
INTRODUCTION: Left atrial (LA) size and function are associated with outcome after myocardial infarction (MI). In this study we aimed to assess the impact of LA function as a predictor of exercise capacity through speckle tracking echocardiography. METHODS: A total of 94 patients (mean age 54.8±11.0 years; 82% male) were enrolled one month after MI. Echocardiography was used to assess LA volumes and various indices of LA conduit, contraction and reservoir function...
September 27, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Shivani M Bhatt, Yan Wang, Okan U Elci, Elizabeth Goldmuntz, Michael McBride, Stephen Paridon, Laura Mercer-Rosa
BACKGROUND: Pulmonary insufficiency (PI) and right ventricular (RV) dysfunction are long-term complications in patients with repaired tetralogy of Fallot (rTOF). The aim of this study was to investigate RV contractile reserve and changes in PI that occur during exercise in patients with rTOF and the associations of these changes with exercise performance using stress echocardiography. METHODS: Subjects with rTOF (n = 32) and healthy control subjects (n = 10) were prospectively enrolled and underwent rest and peak exercise echocardiography during standard cardiopulmonary exercise test protocol on a cycle ergometer or treadmill...
September 27, 2018: Journal of the American Society of Echocardiography
G A Rose, R G Davies, I R Appadurai, W G Lewis, J S Cho, M H Lewis, I M Williams, D M Bailey
NEW FINDINGS: What is the central question of this study? To what extent cardiorespiratory fitness is impaired in patients with abdominal aortic aneurysmal (AAA) disease and corresponding implications for postoperative survival requires further investigation. What is the main finding and its importance? Cardiorespiratory fitness is impaired in patients with AAA disease. Patients with peak oxygen uptake of <13.1 ml O2  kg-1  min-1 and ventilatory equivalent for carbon dioxide at anaerobic threshold ≥34 are associated with increased risk of postoperative mortality at 2 years...
September 26, 2018: Experimental Physiology
Eduardo Foschini Miranda, Welton Alves Diniz, Marcos Vinicius Nogueira Gomes, Marcelo Ferreira Duarte de Oliveira, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
Chronic obstructive pulmonary disease (COPD) is characterized by dyspnea, as well as musculoskeletal and systemic manifestations. Photobiomodulation therapy (PBMT) with use of low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) is an electrophysical intervention that has been found to minimize or delay muscle fatigue. The aim of this study was to evaluate the acute effect of PBMT with combined use of lasers diodes, light-emitting diodes (LEDs), magnetic field on muscle performance, exercise tolerance, and metabolic variables during the 6-minute stepper test (6MST) in patients with COPD...
September 25, 2018: Lasers in Medical Science
Hagen Bomberg, Jonas Stroeder, Kathrin Karrenbauer, Heinrich V Groesdonk, Stefan Wagenpfeil, Matthias Klingele, Arno Bücker, Hans-Joachim Schäfers, Peter Minko
OBJECTIVE: The aim of this study was to develop clinical preoperative, intraoperative, and postoperative scores for early identification of patients who are at risk of nonocclusive mesenteric ischemia (NOMI). DESIGN: A retrospective analysis. SETTING: Single center. PARTICIPANTS: From January 2008 to December 2014, all patients from the Department of Thoracic and Cardiovascular Surgery were included on the basis of the hospital database...
August 24, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Aleksandar Sovtic, Predrag Minic, Gordana Markovic-Sovtic, Goran Z Trajkovic
Introduction: Decreased respiratory muscle strength in patients with cystic fibrosis (CF) may cause progressive exercise intolerance during cardiopulmonary exercise testing (CPET), and may contribute to the development of chronic respiratory insufficiency. The aim of this study is to evaluate exercise tolerance during CPET of children and adults with clinically stable CF who exhibit different respiratory muscle strength. Methods: Sixty-nine clinically stable CF subjects aged 8-33 years underwent spirometry, body plethysmography, CPET, and respiratory muscle strength measurement...
2018: Frontiers in Pediatrics
Filip Eckerström, Christian Emil Rex, Marie Maagaard, Sune Rubak, Vibeke Elisabeth Hjortdal, Johan Heiberg
Background: Asthma is a frequent diagnosis in competitive sports, and inhaled β2 -agonists are commonly used by athletes. Although inhaled β2 -agonists do not seem to improve performance in athletes, it has remained uncertain whether they can increase exercise performance in non-athletes. Objective: To investigate the effect of inhaled β2 -agonists on exercise performance in healthy non-athlete individuals. Methods: In a double-blinded, placebo-controlled, cross-over trial, healthy, non-asthmatic, non-athlete individuals were randomised to inhalation of either 900 µg of salbutamol or placebo...
2018: BMJ Open Sport & Exercise Medicine
Anand S Iyer, James M Wells, Surya P Bhatt, deNay P Kirkpatrick, Patricia Sawyer, Cynthia J Brown, Richard M Allman, Marie A Bakitas, Mark T Dransfield
Background: Social isolation is a common experience in patients with COPD but is not captured by existing patient-reported outcomes, and its association with clinical outcomes is unknown. Methods: We prospectively enrolled adults with stable COPD who completed the University of Alabama at Birmingham Life Space Assessment (LSA) (range: 0-120, restricted Life-Space mobility: ≤60 and a marker of social isolation in older adults); six-minute walk test (6MWT), and the University of California at San Diego Shortness of Breath Questionnaire, COPD Assessment Test, and Hospital Anxiety and Depression Scale...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Keri M Shafer, Alexander R Opotowsky, Jonathan Rhodes
OBJECTIVE: Risk prediction using cardiopulmonary exercise testing (CPET) in complex congenital heart disease tends to either focus on single diagnoses or complete cohorts. We aimed to evaluate patients with two distinct anatomies cared for at a single institution over the same time period to determine CPET variables associated with mortality. DESIGN: All Fontan and tetralogy of Fallot (TOF) subjects with CPET between November 1, 2002 and December 31, 2014 and subsequently died were identified (cases)...
September 14, 2018: Congenital Heart Disease
Katrine Rolid, Arne K Andreassen, Marianne Yardley, Elisabeth Bjørkelund, Kristjan Karason, Julia P Wigh, Christian H Dall, Finn Gustafsson, Lars Gullestad, Kari Nytrøen
AIM: To study exercise capacity and determinants of early peak oxygen consumption (VO2peak ) in a cohort of de novo heart transplant (HTx) recipients. METHODS: To determine possible central (chronotropic responses, cardiopulmonary and hemodynamic function) and peripheral factors (muscular exercise capacity and body composition) predictive of VO2peak , a number of different measurements and tests were performed, as follows: Cardiopulmonary exercise testing (CPET) was performed mean 11 wk after surgery in 81 HTx recipients > 18 years and was measured with breath by breath gas exchange on a treadmill or bicycle ergometer...
September 10, 2018: World Journal of Transplantation
Selina Hein, Fabian Aus Dem Siepen, Ralf Bauer, Hugo A Katus, Arnt V Kristen
INTRODUCTION: Cardiopulmonary exercise testing (CPET) has repeatedly been reported to reliably predict adverse outcomes in different forms of heart failure. However, it has not been elucidated in detail in cardiac amyloidosis (CA). Therefore, we evaluated the predictive value of CPET parameters in patients with CA regarding disease severity and prediction of mortality. METHODS: Twenty-seven consecutive patients with CA were assessed noninvasively, including electrocardiography, echocardiography, CPET, and laboratory tests...
September 7, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
Naoya Kakutani, Arata Fukushima, Takashi Yokota, Takashi Katayama, Hideo Nambu, Ryosuke Shirakawa, Satoshi Maekawa, Takahiro Abe, Shingo Takada, Takaaki Furihata, Kota Ono, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
BACKGROUND: Oxygen uptake (V̇O2 ) at peak workload and anaerobic threshold (AT) workload are often used for grading heart failure (HF) severity and predicting all-cause mortality. The clinical relevance of respiratory exchange ratio (RER) during exercise, however, is unknown. Methods and Results: We retrospectively studied 295 HF patients (57±15 years, NYHA class I-III) who underwent cardiopulmonary exercise testing. RER was measured at rest; at AT workload; and at peak workload...
August 31, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Ewa Kowalik, Anna Klisiewicz, Mirosław Kowalski, Justyna Rybicka, Rafał Baranowski, Elżbieta Katarzyna Biernacka, Piotr Hoffman
BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) is a rare clinical condition in which the morphologically right ventricle sustains systemic circulation. This congenital heart anomaly exposes patients with ccTGA to adverse events over time. Strategies to identify persons who are at high risk of clinical events will be crucial for improving patient outcomes. Thus the aim of this study was to identify screening tools that enable morbidity and mortality risk stratification in adults with ccTGA...
September 2018: Canadian Journal of Cardiology
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