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Cardiopulmonary test prediction

Cassie N Lux, William T N Culp, Matthew S Mellema, Desiree D Rosselli, Chad W Schmiedt, Ameet Singh, April Haynes, Laura E Selmic, Heidi Phillips, Milan Milovancev, Philipp D Mayhew, Dorothy C Brown
OBJECTIVE To determine the most common types of injuries in cats surgically treated for thoracic trauma, complications associated with surgical treatment, and factors associated with mortality rate and evaluate the effectiveness of the animal trauma triage (ATT) scoring system for predicting outcome. DESIGN Retrospective case series with nested observational study. ANIMALS 23 client-owned cats surgically treated for thoracic trauma at 7 veterinary teaching hospitals between 1990 and 2014. PROCEDURES Medical records were reviewed to collect data on signalment, medical history, clinical signs and physical examination findings at initial evaluation, clinicopathologic findings, initial emergency treatments and diagnostic tests performed, type of trauma sustained, imaging findings, surgery details, postoperative complications, duration of hospitalization, and cause of death, if applicable...
September 1, 2018: Journal of the American Veterinary Medical Association
Leonard A Kaminsky, Matthew P Harber, Mary T Imboden, Ross Arena, Jonathan Myers
PURPOSE: Cardiopulmonary exercise testing (CPX) provides valuable clinical information, including peak ventilation (VEpeak), which has been shown to have diagnostic and prognostic value in the assessment of patients with underlying pulmonary disease. This report provides reference standards for VEpeak derived from CPX on treadmills in apparently healthy individuals. METHODS: Nine laboratories in the United States experienced in CPX administration with established quality control procedures contributed to the Fitness Registry and the Importance of Exercise National Database from 2014 to 2017...
August 7, 2018: Medicine and Science in Sports and Exercise
Dany-Michel Marcadet, Bruno Pavy, Gilles Bosser, Frédérique Claudot, Sonia Corone, Hervé Douard, Marie-Christine Iliou, Bénédicte Vergès-Patois, Pascal Amedro, Thierry Le Tourneau, Caroline Cueff, Taniela Avedian, Alain Cohen Solal, François Carré
The exercise test is performed routinely in cardiology; its main indication is the diagnosis of myocardial ischemia, evaluated along with the subject's pretest probability and cardiovascular risk level. Other criteria, such as analysis of repolarization, must be taken into consideration during the interpretation of an exercise test, to improve its predictive value. An exercise test is also indicated for many other cardiac diseases (e.g. rhythm and conduction disorders, severe asymptomatic aortic stenosis, hypertrophic cardiomyopathy, peripheral artery disease, hypertension)...
August 6, 2018: Archives of Cardiovascular Diseases
Fernanda C Lanza, Mariana M Reimberg, Raphael Ritti-Dias, Rebeca S Scalco, Gustavo F Wandalsen, Dirceu Sole, Marco van Brussel, H J Hulzebos, Simone Dal Corso, Tim Takken
Background: Oxygen uptake (VO2 ) evaluations by cardiopulmonary exercise test is expensive and time-consuming. Estimating VO2 based on a field test would be an alternative. Objective: To develop and validate an equation to predict VO2peak based on the modified shuttle test (MST). Methods: Cross sectional study, with 97 children and adolescents with asthma. Participants were divided in two groups: the equation group (EG), to construct the equation model of VO2peak , and the cross-validation group (VG). Each subject performed the MST twice using a portable gas analyzer...
2018: Frontiers in Physiology
Damiano Magri, Piergiuseppe Agostoni, Gianfranco Sinagra, Federica Re, Michele Correale, Giuseppe Limongelli, Elisabetta Zachara, Vittoria Mastromarino, Caterina Santolamazza, Matteo Casenghi, Giuseppe Pacileo, Fabio Valente, Marco Morosin, Beatrice Musumeci, Erika Pagannone, Antonello Maruotti, Massimo Uguccioni, Massimo Volpe, Camillo Autore
BACKGROUND: A blunted heart rate (HR) response is associated with an impaired peak oxygen uptake (pVO2 ), a powerful outcome predictor in hypertrophic cardiomyopathy (HCM). The present multicenter study sought to determine the prognostic role for exercise-induced HR response in HCM. METHODS: A total of 681 consecutive HCM outpatients on optimized treatment were recruited. The heart failure (HF) end-point was death due to HF, cardiac transplantation, NYHA III-IV class progression, HF worsening leading to hospitalization and severe functional deterioration leading to septal reduction...
August 4, 2018: International Journal of Cardiology
Erik H Van Iterson, Sarah E Baker, Courtney M Wheatley, Wayne J Morgan, Thomas P Olson, Eric M Snyder
Cardiac hemodynamic assessment during cardiopulmonary exercise testing (CPET) is proposed to play an important role in the clinical evaluation of individuals with cystic fibrosis (CF). Cardiac catheterization is not practical for routine clinical CPET. Use of oxygen pulse (O2 pulse) as a noninvasive estimate of stroke volume (SV) has not been validated in CF. This study tested the hypothesis that peak exercise O2 pulse is a valid estimate of SV in CF. Measurements of SV via the acetylene rebreathe technique were acquired at baseline and peak exercise in 17 mild-to-moderate severity adult CF and 25 age-matched healthy adults...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
Fred M Wu, Alexander R Opotowsky, Erica R Denhoff, Russell Gongwer, Michelle Z Gurvitz, Michael J Landzberg, Keri M Shafer, Anne Marie Valente, Ahmet Z Uluer, Jonathan Rhodes
BACKGROUND: While the Fontan procedure has improved life expectancy, patients with single ventricle physiology have impaired exercise capacity due to limited increase in pulmonary blood flow during activity. Enhancing the "thoracic pump" using inspiratory muscle training (IMT) may ameliorate this impairment. METHODS: Adult non-smokers with Fontan physiology were recruited through Boston Children's Hospital's outpatient clinic. Participants underwent cardiopulmonary exercise testing and pulmonary function testing, followed by 12 weeks of IMT and then repeat testing...
July 28, 2018: Seminars in Thoracic and Cardiovascular Surgery
Sebastian Udholm, Nael Aldweib, Vibeke Elisabeth Hjortdal, Gruschen R Veldtman
Objective: Exercise impairment is common in Fontan patients. Our aim is to systematically review previous literature to determine the prognostic value of exercise capacity in older adolescent and adult Fontan patients with respect to late outcome. Additionally, we reviewed the determinants of exercise capacity in Fontan patients and changes in exercise capacity over time. Methods: PubMed, CINAHL, Embase, The Cochrane Library and Scopus were searched systematically for studies reporting exercise capacity and late outcome such as mortality, cardiac transplantation and hospitalisation...
2018: Open Heart
Peta M A Alexander, Matthew DiOrio, Kristofer Andren, Kimberlee Gauvreau, Kshitij P Mistry, Derek Mathieu, Jonathan Wright, Catherine K Allan, Meena Nathan, John E Mayer, Ravi R Thiagarajan, Lisa Bergersen
OBJECTIVES: There is increasing demand for the limited resource of Cardiac ICU care. In this setting, there is an expectation to optimize hospital resource use without restricting care delivery. We developed methodology to predict extended cardiac ICU length of stay following surgery for congenital heart disease. DESIGN: Retrospective analysis by multivariable logistic regression of important predictive factors for outcome of postoperative ICU length of stay greater than 7 days...
July 26, 2018: Pediatric Critical Care Medicine
Sara J Abdallah, Benjamin M Smith, Mark A Ware, Michelle Moore, Pei Zhi Li, Jean Bourbeau, Dennis Jensen
RATIONALE: A series of studies conducted ~40 years ago demonstrated an acute bronchodilator effect of smoked cannabis in healthy and asthmatic adults. However, the acute effects of vaporized cannabis on airway function in adults with advanced chronic obstructive pulmonary disease (COPD) remain unknown. OBJECTIVE: To test the hypothesis that inhaled vaporized cannabis would alleviate exertional breathlessness and improve exercise endurance by enhancing static and dynamic airway function in COPD...
July 27, 2018: Annals of the American Thoracic Society
Kwo-Chen Lee, Wen-Hsuan Hsu, Po-Han Chou, Jia-Jean Yiin, Chih-Hsin Muo, Yun-Ping Lin
BACKGROUND: Dementia is characterized by prolonged progressive disability. Therefore, predicting mortality is difficult. An accurate prediction tool may be useful to ensure that end-of-life patients with dementia receive timely palliative care. PURPOSE: This study aims to establish a survival prediction model for elderly patients with dementia in Taiwan. METHODS: Data from the 2001 to 2010 National Health Insurance Research Database in Taiwan were used to identify 37,289 patients with dementia aged ≥65 years for inclusion in this retrospective longitudinal study...
2018: PloS One
A De Lorenzo, C L Da Silva, F C Castro Souza, R De Souza Leao Lima
This study investigated the value of oxygen (O(2)) pulse curves obtained during cardiopulmonary exercise testing (CPET) for the diagnosis of coronary artery disease (CAD). Forty patients with known coronary anatomy (35.0 % normal, 27.0 % single-vessel and 38.0 % multivessel CAD) underwent CPET with radiotracer injection at peak exercise, followed by myocardial scintigraphy. O(2) pulse curves were classified as: A-normal, B-probably normal (normal slope with low peak value); C-probably abnormal (flat, with low peak value); or D- definitely abnormal (descending slope)...
July 25, 2018: Physiological Research
Ernesto Crisafulli, Matteo Vigna, Antonella Ielpo, Panagiota Tzani, Angelo Mangia, Elisabetta Teopompi, Marina Aiello, Veronica Alfieri, Giuseppina Bertorelli, Paolo Palange, Alfredo Chetta
Background Heart rate recovery delay is a marker of cardiac autonomic dysfunction. In chronic obstructive pulmonary disease patients, the ventilatory response to exercise during incremental cardiopulmonary exercise test may add information about dynamic hyperinflation by low values of inspiratory capacity/total lung capacity ratio (at peak) and excess ventilation by the slope of minute ventilation to carbon dioxide output ratio (VE /VCO2 slope ). We aimed to assess if the ventilatory response to exercise might be a determinant for heart rate recovery delay...
January 1, 2018: European Journal of Preventive Cardiology
Doreen DeFaria Yeh, Ada C Stefanescu Schmidt, Aaron S Eisman, John D Serfas, Mariam Naqvi, Mohamed A Youniss, Aaron D Ryfa, Asaad A Khan, Lucy Safi, Sara R Tabtabai, Ami B Bhatt, Gregory D Lewis
OBJECTIVE: The prevalence of heart failure (HF) among adult patients with congenital heart disease (ACHD) is rising. Right ventricle (RV) exercise reserve and its relationship to outcomes have not been characterised. We aim to evaluate the prognostic impact of impaired RV reserve in an ACHD population referred for cardiopulmonary exercise testing (CPET). METHODS: This retrospective study evaluates patients with ACHD who underwent CPET (n=147) with first-pass radionuclide ventriculography at a single tertiary care centre...
July 20, 2018: Heart: Official Journal of the British Cardiac Society
Hideo Ohuchi, Jun Negishi, Hikari Miike, Yuka Toyoshima, Hitomi Morimoto, Midori Fukuyama, Toru Iwasa, Heima Sakaguchi, Aya Miyazaki, Isao Shiraishi, Kenichi Kurosaki, Michikazu Nakai
OBJECTIVE: Exercise training is recommended for its possible favorable effects on Fontan pathophysiology. This study aimed to elucidate the impact of pediatric exercise capacity trajectory, which may mimic the effect of exercise training, on late adult Fontan pathophysiology. METHODS: Since 1990, 97 Fontan patients had consecutively undergone two serial cardiopulmonary exercise tests (CPX1 and CPX2) during childhood (ages 8 ± 2 and 14 ± 2 years) and one during adulthood (CPX3; age 23 ± 5 years)...
July 4, 2018: International Journal of Cardiology
Oded Volovelsky, Tara C Terrell, Hayley Swain, Michael R Bennett, David S Cooper, Stuart L Goldstein
BACKGROUND: Early detection of acute kidney injury (AKI) after cardiac surgery has improved recently with the discovery and validation of novel urinary biomarkers. However, objective tools to predict the risk of AKI before the insult are still missing. We tested the hypothesis that pre-operative serum fibroblast growth factor 23 (FGF23) concentrations would be elevated in children who develop AKI after heart surgery with cardiopulmonary bypass (CPB). We also compared post-operative FGF23 concentrations to other biomarkers for early detection of AKI...
July 19, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Alberto Salas Ballestín, Juan Carlos de Carlos Vicente, Guillem Frontera Juan, Artur Sharluyan Petrosyan, Cristina M Reina Ferragut, Amelia González Calvar, Maria Del Carmen Clavero Rubio, Andrea Fernández de la Ballina
OBJECTIVE: The aim of this study was to evaluate the prognostic factors of patients admitted to a pediatric intensive care unit (PICU) after drowning. METHODS: Retrospective observational study from January 1992 to December 2004 and prospective study from January 2005 to December 2015 were conducted in a tertiary children's hospital PICU. The data analyzed refer to the patient, event, type of resuscitation performed, and clinical situation after resuscitation and at arrival to the PICU; results of additional tests; and clinical evolution and neurological status at discharge from the PICU (categorized as death, severe encephalopathy, or normal)...
July 16, 2018: Pediatric Emergency Care
J A Peterson, S A Maroney, W Zwifelhofer, J P Wood, K Yan, R S Bercovitz, R K Woods, A E Mast
BACKGROUND: Neonates undergoing cardiopulmonary bypass (CPB) are at risk for excessive bleeding. Blood is anticoagulated with heparin during CPB. Heparin activity is reversed with protamine at the end of CPB. Paradoxically, protamine also inhibits blood coagulation when it is dosed in excess of heparin. OBJECTIVES: To evaluate heparin-protamine balance in neonates undergoing CPB using research and clinical assays and determine their association with post-operative bleeding...
July 17, 2018: Journal of Thrombosis and Haemostasis: JTH
Qinglin Yang, Huijuan Meng, Zhong Li, Chuntao Lai, Jiawei Wang, Yingying Su
OBJECTIVE: To compare the accuracy of electroencephalography (EEG) grading scale with amplitude-integrated electroencephalography (aEEG) in predicting poor outcomes (3-month), who sustained coma after cardiopulmonary resuscitation (CPR) in adults. METHODS: A retrospective study was conducted. The patients with post-anoxic coma admitted to intensive care unit (ICU) of Tongren Hospital, Capital Medical University from March 2010 to June 2017 were enrolled. EEG was registered and recorded at least once within 7 days of coma after CPR, while not being subjected to therapeutic hypothermia...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Mathieu Gruet, Laurent Mely, Jean-Marc Vallier
PURPOSE: We evaluated the validity of predicting peak oxygen uptake ([Formula: see text]O2peak ) from submaximal ratings of perceived exertion (RPE) during incremental cardiopulmonary exercise test (CPET) in patients with cystic fibrosis (CF) and compared the predictive accuracy between overall and differentiated RPE scores. METHODS: Thirty-five adults with CF (FEV1  = 58 ± 23%) performed a CPET on cycle ergometer with gas exchange measurements. Leg, chest and overall RPE were collected every minute throughout the test...
July 9, 2018: European Journal of Applied Physiology
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