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https://www.readbyqxmd.com/read/30018555/haplotypic-and-genotypic-association-of-catechol-o-methyltransferase-rs4680-and-rs4818-polymorphisms-and-treatment-resistance-in-schizophrenia
#1
Marina Sagud, Lucija Tudor, Suzana Uzun, Matea Nikolac Perkovic, Maja Zivkovic, Marcela Konjevod, Oliver Kozumplik, Bjanka Vuksan Cusa, Dubravka Svob Strac, Iva Rados, Ninoslav Mimica, Alma Mihaljevic Peles, Gordana Nedic Erjavec, Nela Pivac
Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol- O -methyltransferase (COMT). Variants of the COMT gene have been extensively studied as risk factors for schizophrenia; however, their association with TRS has been poorly investigated. The aim of the present study was to determine the haplotypic and genotypic association of COMT rs4680 and rs4818 polymorphisms with the presence of TRS...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29931536/investigation-of-the-protective-effects-of-horse-mushroom-agaricus-arvensis-schaeff-against-carbon-tetrachloride-induced-oxidative-stress-in-rats
#2
Abdulahad Dogan, Abdullah Dalar, Cemil Sadullahoglu, Abdulhamit Battal, Yusuf Uzun, Ismail Celik, Kenan Demirel
Wild and cultured mushrooms have been extensively used for food and medicinal purposes all around the world. However, there is limited information on chemical composition, health enhancing effects and contributions on diet of some mushrooms (e.g., Agaricus arvensis) widely distributed in many countries including United Kingdom, Australia, Turkey etc. Therefore, the present study was aimed to analyse the bioactive composition and ameliorative effects of A. arvensis via evaluating in vitro and in vivo antioxidant properties in CCl4 induced rat model...
June 21, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29906523/ventricular-fibromas-in-children-arrhythmia-risk-and-outcomes-a-multicenter-study
#3
John P Jones, Tristan Ramcharan, Milind Chaudhari, Vinay Bhole, Karen Mcleod, Shankar Sadagopan, Orhan Uzun, Andrew Parry, Jan Till, Colin J McMahon, Alan G Stuart, Mark A Walsh
BACKGROUND: Although ventricular fibromas are rare, they are the second most common type of cardiac tumor in children. While histologically benign, they have a propensity to cause malignant arrhythmias, with cardiac arrest often being the first presentation. OBJECTIVE: The purpose of this study was to evaluate the arrhythmia risk and management strategies for pediatric ventricular fibromas. METHODS: Fifteen centers in the British Paediatric Arrhythmia Group network were contacted to partake in the study to contribute cases...
June 12, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29803420/the-inclusion-of-fresh-forage-in-the-lactating-buffalo-diet-affects-fatty-acid-and-sensory-profile-of-mozzarella-cheese
#4
P Uzun, F Masucci, F Serrapica, F Napolitano, A Braghieri, R Romano, N Manzo, G Esposito, A Di Francia
The aim of this study was to determine the effect of inclusion of fresh forage in diet for lactating buffalo on properties of mozzarella cheese under intensive farming conditions. Thirty-two buffalo cows were equally allotted into 2 groups fed diets with (fresh group, FRS) or without (control group, CTL) fresh sorghum. The study consisted of 2 trials. In the first one, animals from group FRS were fed a diet containing 10 kg of fresh sorghum (10-FRS diet) that was doubled to 20 kg (20-FRS diet) in the second trial...
August 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29710591/deactivation-of-wastewater-derived-n-nitrosodimethylamine-precursors-with-chlorine-dioxide-oxidation-and-the-effect-of-ph
#5
Habibullah Uzun, Daekyun Kim, Tanju Karanfil
In this study, the effect of chlorine dioxide (ClO2 ) oxidation on the deactivation of wastewater (WW)-derived N-nitrosodimethylamine (NDMA) precursors was investigated under various conditions (i.e., ClO2 application pH, dose and contact time). At pH 6.0, decreases in NDMA formation potentials (FPs) or occurrences (under uniform formation conditions [UFC]) were relatively low (<25%) with ClO2 oxidation regardless of WW-impact. A negative removal was also observed after ClO2 oxidation in some of the non-impacted waters...
September 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29663822/the-effect-of-intrathecal-sufentanil-preconditioning-against-myocardial-ischemia-reperfusion-injury
#6
Y Tire, G Sarkilar, H Esen, R Onoglu, S T Uzun
OBJECTIVES: We aimed to investigate the cardioprotective effect and hemodynamic response of intrathecally administered sufentanil on myocardial IR injury. BACKGROUND: Sufentanil, mu opioid receptor agonist, intravenously administered during clinical and experimental studies, has been shown to have a cardioprotective effect on myocardial ischemia-reperfusion injury. METHODS: Thirty-two New Zealand type rabbits, which were anesthetized, were divided into four equal groups: sham, ischemia-reperfusion, sufentanil and ischemia-reperfusion+sufentanil...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29627678/multiscale-analysis-of-bamboo-deformation-mechanisms-following-naoh-treatment-using-x-ray-and-correlative-microscopy
#7
E Salvati, L R Brandt, F Uzun, H Zhang, C Papadaki, A M Korsunsky
For hundreds of years, bamboo has been employed for a variety of applications ranging from load-bearing structures to textiles. Thanks to its hierarchical structure that is functionally graded and naturally optimised, bamboo displays a variation in properties across its stem that ensures exceptional flexural performance. Often, alkaline solutions are employed for the treatment of bamboo in order to alter its natural elastic behaviour and make it suitable for particular applications. In this work we study the effect of NaOH solutions of five different concentrations (up to 25%) on the elastic properties of bamboo...
May 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29526155/local-application-of-tranexamic-acid-affects-tendon-healing-negatively-in-the-late-period
#8
Alper Çıraklı, Pınar Naile Gürgör, Erdal Uzun, Havva Erdem, Soner Çankaya, Orhan Baş
OBJECTIVES: This study aims to evaluate the potential adverse effects of tranexamic acid (TA) on tendon healing. MATERIALS AND METHODS: Twelve male Wistar-Albino rats (weighing 300 g to 350 g) were used in the study. Rats were divided into two groups. Right legs of the rats were determined as the TA group and left legs as the serum physiologic (SP) group. Bilateral Achilles tenotomy was performed and surgically repaired. For the right side, 1 mL of TA and for the left side, 1 mL of SP were applied...
April 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29493778/effects-of-betamethasone-on-fetoplacental-and-maternal-hemodynamics-in-preterm-pregnancies
#9
Cihan Inan, N Cenk Sayin, Zehra N Dolgun, Selen G Erzincan, Isil Uzun, Havva Sutcu, Necdet Sut, Fusun G Varol
OBJECTIVE: To evaluate the possible effects of prenatal steroid administration on Doppler parameters of the umbilical artery, uterine artery, middle cerebral artery, and ductus venosus, the cerebroplacental ratio, and the amniotic fluid index in preterm fetuses. METHODS: The present prospective observational study was performed at the Perinatology Department of Trakya University, Edirne, Turkey, between June 1, 2015, and September 1, 2016. It included patients with healthy singleton pregnancies who had received betamethasone at 24-34 weeks of pregnancy...
June 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29316524/cholesterol-imprinted-composite-membranes-for-selective-cholesterol-recognition-from-intestinal-mimicking-solution
#10
Mehmet Odabaşı, Lokman Uzun, Gözde Baydemir, Neşe Hayat Aksoy, Ömür Acet, Demet Erdönmez
Molecularly imprinted polymers which have been extensively investigated as selective adsorbents were constructed using a template molecule during the polymerization to gain template-specific cavities. In this study, we prepared cholesterol imprinted poly(2-hydroxyethyl methacrylate-methacryloyamidotryptophan) (PHEMA-MTrp) particles embedded composite membranes. These membranes were characterized through elemental analysis, FTIR, SEM, swelling tests, and surface area measurements. Adsorption experiments were performed in a batch experimental set-up, and the adsorption medium was either a methanol or intestinal-mimicking solution...
March 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29283955/effects-of-reaching-national-goals-on-hiv-incidence-by-race-and-ethnicity-in-the-united-states
#11
Evin Uzun Jacobson, Katherine A Hicks, Emily L Tucker, Paul G Farnham, Stephanie L Sansom
CONTEXT: Human immunodeficiency virus (HIV) incidence and prevalence in the United States are characterized by significant disparities by race/ethnicity. National HIV care goals, such as boosting to 90% the proportion of persons whose HIV is diagnosed and increasing to 80% the proportion of persons living with diagnosed HIV who are virally suppressed, will likely reduce HIV incidence, but their effects on HIV-related disparities are uncertain. OBJECTIVE: We sought to understand by race/ethnicity how current HIV care varies, the level of effort required to achieve national HIV care goals, and the effects of reaching those goals on HIV incidence and disparities...
July 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29173483/assessing-the-boron-nutritional-status-by-analyzing-its-cummulative-frequency-distribution-in-the-hair-and-whole-blood
#12
Juraj Prejac, Andrey A Skalny, Andrei R Grabeklis, Suzana Uzun, Ninoslav Mimica, Berislav Momčilović
Boron is a non-essential ubiquitous trace element in the human body. The aim of this study was to assess boron nutritional status by analyzing boron frequency distribution in the long-term biological indicator tissue of hair and the short-term biological indicator of whole blood. Hair samples were analyzed in 727 apparently healthy subjects (263 ♂ and 464 ♀) and the whole blood boron was analyzed in the random subsample of them (80 ♂ and 152 ♀). Samples were analyzed by the ICP-MS at the Center for Biotic Medicine, Moscow, Russia...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29061917/production-and-mechanical-properties-of-ti-5al-2-5fe-xcu-alloys-for-biomedical-applications
#13
Ridvan Yamanoglu, Erdinc Efendi, Fetiye Kolayli, Huseyin Uzuner, Ismail Daoud
In this study, the mechanical, antibacterial properties and cell toxicity response of Ti-5Al2.5Fe alloy with different copper contents were investigated. The alloys were prepared by high-energy ball milling using elemental Ti, Al, Fe, and Cu powders and consolidated by a uniaxial vacuum hot press. Staphylococcus aureus strain ATCC 29213 and Escherichia coli strain ATCC 25922 were used to determine the antibacterial properties of the sintered alloys. The in vitro cytotoxicity of the samples was evaluated with HeLa (ATTC, CCL-2) cells using thiazolyl blue tetrazolium bromide...
January 30, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/28983005/complete-genome-coding-sequences-of-artashat-burana-caspiy-chim-geran-tamdy-and-uzun-agach-viruses-bunyavirales-nairoviridae-orthonairovirus
#14
Sergey V Alkhovsky, Dmitry K Lvov, Alexey M Shchetinin, Petr G Deriabin, Mikhail Y Shchelkanov, Valeriya A Aristova, Tatyana N Morozova, Asya K Gitelman, Gustavo F Palacios, Jens H Kuhn
The bunyaviral monogeneric family Nairoviridae currently includes 12 species for 35 distinct viruses. Here, we present the complete genome coding sequences of an additional seven nairoviruses. Five of them can be assigned to established species, whereas two of them (Artashat and Chim viruses) ought to be assigned to two novel species.
October 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#15
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28881244/disinfection-byproduct-precursor-dynamics-and-water-treatability-during-an-extreme-flooding-event-in-a-coastal-blackwater-river-in-southeastern-united-states
#16
A Ruecker, H Uzun, T Karanfil, M T K Tsui, A T Chow
Coastal blackwater rivers, characterized by high concentrations of natural organic matter, are source water for millions of people in the southeastern US. In October 2015, large areas of coastal South Carolina were flooded by Hurricane Joaquin. This so-called "thousand-year" rainfall mobilized and flushed large amounts of terrestrial organic matter and associated pollutants (e.g. mercury) into source water, affecting water quality and safety of municipal water supply. To understand the dynamics of water quality and water treatability during this extreme flood, water samples were collected from Waccamaw River (a typical blackwater river in the southeastern US) during rising limb, peak discharge, falling limb, and base flow...
December 2017: Chemosphere
https://www.readbyqxmd.com/read/28613136/biosorption-of-basic-blue-7-by-fungal-cells-immobilized-on-the-green-type-biomatrix-of-phragmites-australis-spongy-tissue
#17
Tamer Akar, Cansu Uzun, Sema Çelik, Sibel Tunali Akar
Biosorption is an effective alternative method for the control of water pollution caused by different pollutants such as synthetic dyes and metals. A new and efficient biomass system was developed from the passively immobilized fungal cells. The spongy tissue of Phragmites australis was considered as the carrier for the immobilization of Neurospora sitophila cells employed for the biosorption of Basic Blue 7. This plant tissue was used for the first time as a carrier for fungal cells. The biosorption was examined through batch- and continuous-mode operations...
January 28, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28412383/a-prospective-international-aspergillus-terreus-survey-an-efisg-isham-and-ecmm-joint-study
#18
MULTICENTER STUDY
B Risslegger, T Zoran, M Lackner, M Aigner, F Sánchez-Reus, A Rezusta, A Chowdhary, S J Taj-Aldeen, M C Arendrup, S Oliveri, D P Kontoyiannis, A Alastruey-Izquierdo, K Lagrou, G Lo Cascio, J F Meis, W Buzina, C Farina, M Drogari-Apiranthitou, A Grancini, A M Tortorano, B Willinger, A Hamprecht, E Johnson, L Klingspor, V Arsic-Arsenijevic, O A Cornely, J Meletiadis, W Prammer, V Tullio, J-J Vehreschild, L Trovato, R E Lewis, E Segal, P-M Rath, P Hamal, M Rodriguez-Iglesias, E Roilides, S Arikan-Akdagli, A Chakrabarti, A L Colombo, M S Fernández, M T Martin-Gomez, H Badali, G Petrikkos, N Klimko, S M Heimann, J Houbraken, O Uzun, M Edlinger, S de la Fuente, C Lass-Flörl
OBJECTIVES: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. METHODS: A total of 370 cases from 21 countries were evaluated. RESULTS: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0...
October 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28371864/a-multicentre-study-of-patients-with-timothy-syndrome
#19
Mark A Walsh, Christian Turner, Katherine W Timothy, Neil Seller, Dominic L Hares, Andrew F James, Jules C Hancox, Orhan Uzun, Dean Boyce, Alan G Stuart, Paul Brennan, Caroline Sarton, Karen McGuire, Ruth A Newbury-Ecob, Karen Mcleod
Aims: Timothy syndrome (TS) is an extremely rare multisystem disorder characterized by marked QT prolongation, syndactyly, seizures, behavioural abnormalities, immunodeficiency, and hypoglycaemia. The aim of this study was to categorize the phenotypes and examine the outcomes of patients with TS. Methods and results: All patients diagnosed with TS in the United Kingdom over a 24-year period were reviewed. Fifteen centres in the British Congenital Arrhythmia Group network were contacted to partake in the study...
February 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28256482/the-antifungal-activity-and-cytotoxicity-of-silver-containing-denture-base-material
#20
A Kurt, G Erkose-Genc, M Uzun, Z Emrence, D Ustek, G Isik-Ozkol
OBJECTIVE: Denture base materials are susceptible to fungal adhesion, which is an important etiological issue in the pathogenesis of denture stomatitis. The purpose of this in vitro study was to evaluate the antifungal activity and cytotoxicity of denture base material containing silver microparticles. MATERIALS AND METHODS: The polymethyl methacrylate (PMMA) denture base material was used, and silver microparticles were added to the polymer powder in different concentrations by volume (0%, 0...
March 2017: Nigerian Journal of Clinical Practice
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