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METs- metabolic syndrome

Xin Zhang, Seo Rin Kim, Christopher M Ferguson, Behzad Ebrahimi, Ahmad F Hedayat, Amir Lerman, Lilach O Lerman
Background: The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity-metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. Methods: Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n=7 each)...
August 9, 2018: American Journal of Hypertension
Phalakorn Suebsamran, Taksin Pimpak, Patnapa Thani, Parinya Chamnan
BACKGROUND: Although metabolic syndrome (MetS) has become a significant public health problem worldwide, little evidence exists to describe the prevalence of MetS in school children using MetS different classifications, and its association with health-related behaviors. METHODS: Using data on 393 children and adolescents aged 13-16 years participating in the Ubon Ratchathani Metabolic Syndrome in Adolescent (UMeSIA) Project, the prevalence of MetS was determined using the International Diabetes Federation (IDF) 2007 definition and other three classifications reported in the previous literature...
August 14, 2018: Metabolic Syndrome and related Disorders
Yun Kyung Cho, Yu Mi Kang, Jee Hee Yoo, Jiwoo Lee, Seung Eun Lee, Dong Hyun Yang, Joon-Won Kang, Joong-Yeol Park, Chang Hee Jung, Hong-Kyu Kim, Woo Je Lee
It is unclear whether non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease. We examined the independent impact of NAFLD on the progression of the coronary artery calcification (CAC) score, a well-known marker of atherosclerosis progression. We examined 1,173 asymptomatic participants who underwent repeated CAC score measurement during routine health examinations. The subjects were categorised into four groups based on the presence (+) or absence (-) of NAFLD and metabolic syndrome (MetS)...
August 13, 2018: Scientific Reports
David Bode, Tim Guthof, Burkert M Pieske, Frank R Heinzel, Felix Hohendanner
In this article, we describe an optimized, Langendorff-based procedure for the isolation of single-cell atrial cardiomyocytes (ACMs) from a rat model of metabolic syndrome (MetS)-related heart failure with preserved ejection fraction (HFpEF). The prevalence of MetS-related HFpEF is rising, and atrial cardiomyopathies associated with atrial remodeling and atrial fibrillation are clinically highly relevant as atrial remodeling is an independent predictor of mortality. Studies with isolated single-cell cardiomyocytes are frequently used to corroborate and complement in vivo findings...
July 26, 2018: Journal of Visualized Experiments: JoVE
Marija Polovina, Gerhard Hindricks, Aldo Maggioni, Massimo Piepoli, Panos Vardas, Milika Ašanin, Dijana Ðikic, Nemanja Ðuricic, Ivan Milinkovic, Petar M Seferovic
Aims: Evidence suggests an excess risk of non-thromboembolic major adverse cardiac events (MACE) associated with atrial fibrillation (AF), particularly in individuals free of overt coronary artery disease (CAD). Metabolic syndrome (MetS) increases cardiovascular risk in the general population, but less is known how it influences outcomes in AF patients. We aimed to assess whether MetS affects the risk of MACE in AF patients without overt CAD. Methods and results: This prospective, observational study enrolled 843 AF patients (mean-age, 62...
August 7, 2018: European Heart Journal
Aniruddha Mukherjee, Bina K Mehta, Kalyan K Sen, Sugato Banerjee
OBJECTIVE: The objective of the study was to characterize the mechanism associated with metabolic syndrome (MetS)-associated cognitive decline and determine the effect of minocycline on the above condition in mice. MATERIALS AND METHODS: We developed a HFHC diet-induced MetS model in mice. Diagnostic characteristics of MetS including waist circumference, lipid levels, blood pressure, and fasting blood glucose were measured in these Swiss albino mice. Cognitive parameters were measured using passive avoidance and elevated plus maze test...
March 2018: Indian Journal of Pharmacology
Jaqueline Garcia-Silva, María Isabel Peralta-Ramírez, Nuria Navarrete Navarrete, Daniele Silva-Silva, Vicente E Caballo
OBJECTIVE: Self-efficacy refers to beliefs in individuals' own capacities to do something. With the intent of evaluate the validity and reliability, we investigated the psychometric properties of the Self-Efficacy to Regulate Exercise Scale (SERES) in patients with metabolic syndrome (MetS). METHODS: 135 participants with medical diagnosis of MetS took part in the study (Mage=55.5, SD=7.6). We investigated sociodemographic, psychological, and life-style variables...
August 14, 2018: Revista Española de Salud Pública
Byoungjin Park, Yong-Jae Lee
BACKGROUND: Metabolic syndrome (MetS) is clinically important because of its association with increased risk of sudden cardiac death, as well as cardiovascular disease-related mortality. Data between MetS and prolonged corrected QT (QTc) intervals, a useful predictor of sudden cardiac death, are limited in apparently healthy adults. OBJECTIVE: This study determined the association between MetS and QTc interval in apparently healthy Korean men and women. METHODS: We examined the association between MetS and QTc interval in 2157 Korean adults (1317 men and 840 women) in a health examination program but excluded participants with a history of ischemic heart disease, stroke, cardiac arrhythmia, cancer, thyroid, respiratory, renal, hepatobiliary, or rheumatologic disease...
July 20, 2018: Journal of Clinical Lipidology
Jaqueline Garcia-Silva, Nuria N Navarrete, María Isabel Peralta-Ramírez, Antonio García-Sánchez, Miguel Ángel Ferrer-González, Vicente E Caballo
OBJECTIVE: Verify the efficacy of cognitive behavioral therapy (CBT) in adherence to the Mediterranean diet (MedDiet) in metabolic syndrome (MetS) patients. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: In the Multimodal Intervention Program for Patients with Metabolic Syndrome clinical trial, 79 MetS patients completed the intervention. Of those, 48 belonged to the experimental group and 31 to the control group. The intervention received by the experimental group was CBT; the control group followed usual care and attended a workshop on healthy lifestyle...
August 9, 2018: Journal of Nutrition Education and Behavior
C S A Monção, L N Martins, M P S Penteado, R C P Reis, F M M Santos, C C D Lanna, A L Ribeiro, R W Telles
Objectives To evaluate the incidence and variability of traditional coronary artery disease (CAD) risk factors in a cohort of lupus patients and to investigate if prednisone use predicts an increase in the number of risk factors. Methods A total of 151 women, 37.8 ± 11.1 (mean ± SD) years old at baseline, were reevaluated after a median period of 39 (interquartile range 36.5-42.0) months. The cumulative incidence of traditional risk factors, the incidence rate (with 95% confidence interval) of hypertension, diabetes, dyslipidemia and hypertriglyceridemia, and the frequency of the risk factors' disappearance were calculated...
August 12, 2018: Lupus
Chandima N D Balasuriya, Astrid Kamilla Stunes, Mats P Mosti, Berit Schei, Marit S Indredavik, Ingrid K Hals, Kari Anne I Evensen, Unni Syversen
Context and objectives: Low birth weight (LBW) has emerged as a risk factor of metabolic syndrome (MetS). Whether very low birth weight (VLBW) adults born preterm are at higher risk than term-born small for gestational age (tb-SGA) individuals is not established. We assessed metabolic outcomes, including relation with skeletal parameters, in these two LBW categories. Design, participants and outcomes: This follow-up cohort study included 189 individuals (females 51%), 25 to 28 years; 55 preterm VLBW (≤1500g), 59 tb-SGA (<10th percentile), and 75 controls (>10th percentile)...
August 6, 2018: Journal of Clinical Endocrinology and Metabolism
Zobida Islam, Shamima Akter, Takeshi Kochi, Huanhuan Hu, Masafumi Eguchi, Miwa Yamaguchi, Keisuke Kuwahara, Isamu Kabe, Tetsuya Mizoue
OBJECTIVE: Social jetlag, ie, the mismatch between biological and social timing, has been suggested to induce obesity and cardiometabolic abnormalities. Yet, no study has currently linked social jetlag to metabolic syndrome (MetS) among Asians. The aim of this study was to investigate the cross-sectional association of social jetlag with MetS in a Japanese working population. METHODS: Participants were 1164 employees, aged 18-78 years, who completed a health survey at a periodic checkup...
July 12, 2018: Sleep Medicine
Zhou-Feng Chen, Xiu-Li Dong, Qing-Ke Huang, Wang-Dong Hong, Wen-Zhi Wu, Jian-Sheng Wu, Shuang Pan
BACKGROUND: This research aimed to investigate whether metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) had both individual and synergistic effects on the prognosis for female colorectal carcinoma (CRC) patients. METHODS: The relationship between CRC prognosis and NAFLD as well as MetS was evaluated in 764 female participants. Based on the NAFLD level, patients were divided into significant NAFLD (SNAFLD), "moderate" and "severe" level, and non-SNAFLD, "non" and "mild" level...
August 10, 2018: World Journal of Surgical Oncology
Heidi Hakkarainen, Hanna Huopio, Henna Cederberg, Raimo Voutilainen, Seppo Heinonen
BACKGROUND: Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring. METHODS: Eight hundred seventy six women treated for their pregnancies in Kuopio University Hospital in 1989-2009 underwent a follow-up study (mean follow-up time 7...
August 10, 2018: BMC Pregnancy and Childbirth
Catherine M Phillips, Nitin Shivappa, James R Hébert, Ivan J Perry
Accumulating evidence identifies diet and inflammation as potential mechanisms contributing to cardiometabolic risk. However, inconsistent reports regarding dietary inflammatory potential, biomarkers of cardiometabolic health and metabolic syndrome (MetS) risk exist. Our objective was to examine the relationships between a food frequency questionnaire (FFQ)-derived dietary inflammatory index (DII® ), biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis and MetS risk in a cross-sectional sample of 1992 adults...
August 8, 2018: Nutrients
PreyaJanubhai Patel, Fabrina Hossain, Leigh Ula Horsfall, Xuan Banh, Kelly Lee Hayward, Suzanne Williams, Tracey Johnson, Anne Bernard, Nigel Neil Brown, Guy Lampe, Lyndall Buck, Nivene Saad, Anthony William Russell, Patricia Casarolli Valery, Katharine Margaret Irvine, Andrew Donald Clouston, Katherine Anne Stuart, William Rosenberg, Elizabeth Ellen Powell
Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], fibrosis 4 score [FIB-4], or enhanced liver fibrosis [ELF] test) are recommended as first-line tools to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease. We aimed to assess the utility of a pragmatic approach to screening for clinically significant fibrosis in primary care and diabetes clinics. We recruited 252 patients from an endocrine clinic or primary care facility. Anthropometric measurements, ELF test, ultrasound, and liver stiffness measurements (LSMs) were performed...
August 2018: Hepatology communications
Ryszard Ślęzak, Przemysław Leszczyński, Magdalena Warzecha, Łukasz Łaczmański, Błażej Misiak
BACKGROUND: Accumulating evidence indicates the potential involvement of the FTO gene polymorphisms in the etiology of metabolic syndrome (MetS) and related disorders. OBJECTIVES: In this study, we aimed to investigate whether the FTO gene polymorphisms are associated with the risk of MetS and its simple components in a homogeneous sample of males. MATERIAL AND METHODS: Anthropometric and biochemical parameters were assessed in 192 males. A total of 100 males met the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria for a diagnosis of MetS...
August 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Tetyana Kendzerska, Lauren K King, Lorraine Lipscombe, Ruth Croxford, Ian Stanaitis, Gillian A Hawker
AIMS/HYPOTHESIS: This study examined the relationship between hip/knee osteoarthritis and incident diabetes. We hypothesised that hip/knee osteoarthritis would be independently related to an increased risk of incident diabetes and that this relationship would be due, at least in part, to walking difficulty. We also hypothesised a stronger relationship with incident diabetes for knee than hip osteoarthritis because of the higher prevalence in the former of obesity/the metabolic syndrome...
August 8, 2018: Diabetologia
Eman Mokbel Alissa
Objectives: The objective of this study was to examine the associations of serum gamma-glutamyltransferase (GGT) levels with the metabolic syndrome (MetS) and its components in Saudi adults. Methods: The study comprised 400 participants (70 men and 330 women), aged between 40 and 88 years, randomly selected from the medicine clinics at the King Abdulaziz University Hospital in Jeddah, Saudi Arabia, in a cross-sectional study design. A standardized questionnaire was used to determine demographics variables, general health, lifestyle habits, and medical history...
March 2018: Journal of Family Medicine and Primary Care
Samim Ali Mondal, Deep Dutta, Manoj Kumar, Pankaj Singh, Madhurima Basu, Chitra Selvan, Satinath Mukhopadhyay
Background and Objectives: Nonalcoholic fatty liver disease (NAFLD) and dysglycemia are public health challenges. There is urgent need for anthropometric surrogates for NAFLD screening. This study evaluated role of neck circumference (NC) and neck-height ratio (NHtR) as predictors of liver stiffness measure (LSM) in individuals with prediabetes (IPD). Methods: In a cross-sectional study, 188 IPD from 1130 screened individuals underwent anthropometry, ultrasonography, Fibroscan® for LSM, dyslipidemia, insulin resistance (IR), and fetuin-A assessment...
May 2018: Indian Journal of Endocrinology and Metabolism
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