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METs- metabolic syndrome

Qing Peng, Carrie A Karvonen-Gutierrez, John F Randolph, Bin Nan, Daniel McConnell, Siobán D Harlow
Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population. Design: Women with PCOS-like status ("PCOSp") were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index and high levels of anti-müllerian hormone...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
M D DeBoer, S L Filipp, M J Gurka
BACKGROUND: Among adolescents, obesity and the metabolic syndrome (MetS) contribute to adult cardiovascular disease risk. By parent report, obesity prevalence in the USA was highest in the South. OBJECTIVES: The aim of this study was to determine the prevalence of obesity and MetS by US division and region. METHODS: We used in-person assessment of 4600 US adolescents age 12-19 years participating in the National Health and Nutrition Examination Survey, 1999-2014...
December 4, 2018: Pediatric Obesity
Farzad Amirabdollahian, Fahimeh Haghighatdoost
Frequently reported poor dietary habits of young adults increase their risk of metabolic syndrome (MetS). Excess adiposity is the most established predictor of MetS, and numerous anthropometric measures have been proposed as proxy indicators of adiposity. We aimed to assess prevalence of MetS in young adult population and to make comparison between weight- and shape-oriented measures of adiposity to identify the best index in association with measured body fat and as a risk predictor for MetS. Healthy males and females aged 18-25 years from the Northwest of England were recruited using convenience sampling ( n =550)...
2018: Journal of Obesity
Violet Kasabri, Esraa Shawakri, Amal Akour, Randa Naffa, Nahla Khawaja, Ibrahim Al-Sarraf, Jameel Bzour
Background: Oxytocin (OXT), fetuin-A and interleukin-18 (IL-18) are involved in the development and progression of metabolic syndrome (MetS) and prediabetes (pre/T2DM). Aims participants and methods: This study aimed to compare and correlate the plasma levels of OXT, fetuin-A and IL-18 with clinical parameters, haematological indices and adiposity indices in Jordanian MetS subjects. In a cross-sectional study, 30 normoglycaemic lean study participants (control), 30 MetS study participants, and 29 MetS pre/T2DM study participants were recruited...
December 2018: Therapeutic Advances in Endocrinology and Metabolism
Jessica A Grieger, Tina Bianco-Miotto, Luke E Grzeskowiak, Shalem Y Leemaqz, Lucilla Poston, Lesley M McCowan, Louise C Kenny, Jenny E Myers, James J Walker, Gus A Dekker, Claire T Roberts
BACKGROUND: Obesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been investigated. METHODS AND FINDINGS: Low-risk, nulliparous women were recruited to the multi-centre, international prospective Screening for Pregnancy Endpoints (SCOPE) cohort between 11 November 2004 and 28 February 2011...
December 2018: PLoS Medicine
F Aghakhanian, C Wong, J S Y Tan, L F Yeo, A Ramadas, J Edo, B P Hoh, B A K Khalid, M E Phipps
OBJECTIVES: This study was undertaken to investigate the occurrence of metabolic syndrome (MetS) and cardiovascular disease (CVD) risk in Orang Asli (OA), the indigenous people of Peninsular Malaysia. OA consist of Negrito, Proto-Malay, and Senoi groups who collectively comprise only 0.76% of the population of Peninsular Malaysia. Owing to the challenges in accessing their remote villages, these groups are often excluded in larger government health surveys. Although tropical diseases were scourges in the past, with rapid national development, many OA communities have been gradually urbanized...
November 30, 2018: Public Health
Elke Parsi, Norman Bitterlich, Anne Winkelmann, Daniela Rösler, Christine Metzner
BACKGROUND: Cardiac arrhythmias (CA) are very common and may occur with or without heart disease. Causes of these disturbances can be components of the metabolic syndrome (MetS) or deficits of micronutrients especially magnesium, potassium, B vitamins and coenzyme Q10. Both causes may also influence each other. Insulin resistance (IR) is a risk factor for diastolic dysfunction. One exploratory outcome of the present pilot study was to assess the impact of a dietary intervention with specific micronutrients on the lowering of IR levels in patients with CA with the goal to improve the left ventricular (LV) function...
December 3, 2018: BMC Cardiovascular Disorders
Neetu K Sodhi, Anita L Nelson
Background: Women with a history of gestational diabetes (GDM) are at risk for development of both overt Type 2 diabetes (T2DM) and cardiovascular disease (CVD) at higher rates and at earlier ages than control women. Current guidelines recommend longitudinal testing of glucose tolerance for women with prior GDM, but no formal assessments of cardiovascular disease are suggested. This study estimated the prevalence of metabolic syndrome in women with GDM in recent pregnancy who were followed for at least 1 year postpartum to quantify their cardiovascular risks...
2018: Contraception and Reproductive Medicine
Carolina A Carvalho, Antônio Augusto M Silva, Maria Cecília F Assunção, Poliana Cristina A Fonseca, Marco Antonio Barbieri, Heloisa Bettiol, Nitin Shivappa, James R Hébert
OBJECTIVE: The aim of this study was to assess the association between the inflammatory potential of diet, as measured by the dietary inflammatory index (DII) and insulin resistance (IR) or metabolic syndrome (MetS). METHODS: A cross-sectional study (nested within a cohort) was conducted on 2017 adults 23 to 25 y of age in Ribeirão Preto, Brazil. Food consumption was assessed using a validated food frequency questionnaire. DII scores were calculated from 35 available food parameters...
August 23, 2018: Nutrition
Omorogieva Ojo, Xiao-Hua Wang, Osarhumwese Osaretin Ojo, Jude Ibe
Background : People who abuse substances are at increased risk of metabolic syndrome and diabetes resulting partly from increased cell damage and due to the effects of opioids on glucose homeostasis. Therefore, people with diabetes who abuse substances may carry greater health risks than the general population resulting from their effect on glucose metabolism. These substances may be in the form of cannabis, hallucinogens, opioids, and stimulants. Therefore, the aim of this review was to evaluate the effects of substance abuse on blood glucose parameters in patients with diabetes...
November 29, 2018: International Journal of Environmental Research and Public Health
Dong Wang, Xiao-Hong Yang, Ji-Dong Zhang, Rui-Bin Li, Min Jia, Xiao-Ran Cui
BACKGROUND & AIMS: Ticagrelor has been acknowledged as a new oral antagonist of P2Y12-adenosine diphosphate receptor, as a strategy with more rapid onset as well as more significant platelet inhibition function in acute coronary syndrome (ACS) patients. The clinical benefit of ticagrelor compared with clopidogrel remains controversial. The current meta-analysis was conducted to better evaluate the role of ticagrelor in comparison of clopidogrel in treating ACS patients. METHODS: The publications involving the safety as well as the efficacy of clopidogrel versus ticagrelor were screened and identified updated to June 2018...
November 29, 2018: BMC Cardiovascular Disorders
Thomas Jensen, Amanda Wieland, Melanie Cree-Green, Kristen Nadeau, Shelby Sullivan
Nonalcoholic fatty liver disease (NAFLD) is quickly emerging as a global epidemic in parallel with the rise in obesity and the Metabolic Syndrome. NAFLD, once seen simply as a passive consequence of the Metabolic Syndrome (MetS), has been found to interact with other features of MetS to exacerbate insulin resistance, diabetes, and cardiovascular disease. NAFLD is also becoming the top indication for liver transplant and an important risk factor for hepatocellular carcinoma. Treatment of this disorder is limited mainly to lifestyle modifications to promote weight loss along with consideration for off-label use of certain medications, but recent progression in clinical trials means more effective treatments are on the horizon...
November 29, 2018: Postgraduate Medicine
Musa Moh'd Waleed Al-Batsh, Abla Albsoul-Younes, Violet Kasabri, Maysa Suyagh, Sundos Alalawi, Nada Yasin
Background Pentraxin-3 (PXT-3) and cystatin-C (Cys-C) are robustly related with central obesity and insulin resistance in prediabetes/metabolic syndrome (preDM-MetS). Materials and methods This cross-sectional study aimed to compare and correlate PXT-3 and Cys-C plasma levels in 29 normoglycemic MetS patients, 30 newly diagnosed drug naive preDM-MetS cases vs. 29 normoglycemic lean controls. Results Unlike PXT-3; Cys-C level was significantly higher in normoglycemic MetS (but not preDM-MetS) vs. healthy controls...
November 29, 2018: Hormone Molecular Biology and Clinical Investigation
S Moreno-Fernández, M Garcés-Rimón, J A Uranga, J Astier, J F Landrier, M Miguel
Nutritional compounds could be a safe and less expensive treatment for complications associated with obesity and metabolic syndrome (MetS). The aim of this study was to investigate the mechanism of action and the target tissues of a pepsin egg white hydrolysate (EWH) which had previously been demonstrated to improve some obesity-related disorders on a high-fat/high-glucose rat model. Wistar rats were used and divided into 3 groups: Control group (C), High-fat/high-glucose diet (MS) and high-fat/high-glucose diet + EWH (MSH)...
November 29, 2018: Food & Function
Ayeeshik Kole, Yingchun Cao, Jie Hui, Islam A Bolad, Mouhamad Alloosh, Ji-Xin Cheng, Michael Sturek
Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology...
November 28, 2018: Journal of Cardiovascular Translational Research
Melissa D Olfert, Amanda Dent, Rachel A Wattick
Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Virginia University. The prevalence of MetS in this population was 15%. There was no difference in MetS prevalence between male students and female students (18.8% males and 11.1% females, p -value = 0...
November 27, 2018: Journal of Clinical Medicine
Toru Shimizu, Hiroshi Hori, Masanori Umeyama, Kentaro Shimizu
OBJECTIVE: To clarify the clinical and laboratory characteristics of nephrolithiasis in gout by computed tomography (CT). METHODS: In 350 gout patients, unenhanced CT was performed at the 1st visit to hospital. Calculus density spots exceeding 1 mm in diameter with a CT value >120 Hounsfield units in the kidneys were defined as kidney stones. The association between laterality and the number of stones was investigated in each stone carrier. The 350 patients were classified into three groups (bilateral, unilateral and non-stone carriers)...
November 28, 2018: International Journal of Rheumatic Diseases
Amaya Lopez-Pascual, Jéssica Arévalo, J Alfredo Martínez, Pedro González-Muniesa
Background: Metabolic syndrome (MetS) is characterized by the clustering of hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol levels and central adiposity. Altitude has been proposed as a protective factor to prevent the development of MetS and its components. Aim: To determine whether living at geographical elevation is associated with MetS and its individual components after adjustment for potential confounders in an Ecuadoran population. Methods: The study included 260 Ecuadoran university graduates over 20 years of age, from the coastal or the Andean Altiplano region...
2018: Frontiers in Endocrinology
Alireza Ostadrahimi, Zeinab Nikniaz, Elnaz Faramarzi, Asghar Mohammadpoorasl, Khalil Ansarin, Mohammad Hossein Somi
Background: We decided to assess the correlation between metabolic syndrome (MetS) risks,sleep and napping duration in Azar cohort population according to the increasing incidence of MetS in the world and inconsistence results about sleep duration and MetS. Methods: In this cross-sectional study, MetS and sleep habits of 14916 subjects (35-70 years old) who inhabited in Shabestar city were determined by ATPIII and Pittsburg questionnaire respectively. Inclusion criteria were subjects with 35-70 years old and living in Shabestar for at least 9 months of the year...
2018: Health Promotion Perspectives
Trevor T Nyakudya, Emmanuel Mukwevho, Kennedy H Erlwanger
Background: Consumption of fructose-rich diets has been implicated in the increasing global prevalence of metabolic syndrome (MetS). Interventions during periods of early ontogenic developmental plasticity can cause epigenetic changes which program metabolism for positive or negative health benefits later in life. The phytochemical oleanolic acid (OA) possesses anti-diabetic and anti-obesity effects. We investigated the potential protective effects of neonatal administration of OA on the subsequent development of high fructose diet-induced metabolic dysfunction in rats...
2018: Nutrition & Metabolism
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