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METs- metabolic syndrome

Meghan E Byrne, Marian Tanofsky-Kraff, Nichole M Kelly, Anne Claire Grammer, Manuela Jaramillo, Sarah J Mi, Monika M Stojek, Lisa M Shank, Natasha L Burke, Omni Cassidy, Natasha A Schvey, Sheila M Brady, Andrew P Demidowich, Miranda M Broadney, Susan Z Yanovski, Jack A Yanovski
Objective:  Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods:  A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety...
October 18, 2018: Journal of Pediatric Psychology
Hyun Yoon, Yo Sang Yoon, Sung Gil Kim, Hye Jong Oh, Cheol Won Choi, Jeong Min Seong, Jong Park
AIMS: The present study was conducted to assess the association of metabolic syndrome (MetS) and the MetS score (MSS) with β-cell function by gender in Korean non-diabetic populations. METHODS: This study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older. RESULTS: After adjusting for related variables (with exception of body mass index [BMI]), MetS (p < 0.001) and MSS (p < 0...
October 19, 2018: Endocrine Research
Zdenka Gasparova, Pavol Janega, Peter Weismann, Hisham El Falougy, Barbara Tyukos Kaprinay, Boris Liptak, Dominika Michalikova, Ruzena Sotnikova
Fat-rich diet (FRD) triggers health complications like hypertension, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease, known as the risk factors of metabolic syndrome (MetS), which may result in neurological deficits. The impact of MetS on neuronal functions and brain morphology are poorly understood. We induced MetS-like conditions by exposing hypertriacylglycerolemic (HTG) rats to FRD for eight weeks with the aim to study possible neurological dysfunctions. HTG-FRD rats were compared to HTG rats and Wistar rats on standard diet...
October 19, 2018: General Physiology and Biophysics
Arash Aghajani Nargesi, Xiang-Yang Zhu, LaTonya J Hickson, Sabena M Conley, Andre J van Wijnen, Lilach O Lerman, Alfonso Eirin
Mesenchymal stem cells (MSCs) are currently being tested in several clinical trials. Mitochondria regulate many aspects of MSC function. Mitochondrial preproteins are rapidly translated and trafficked into the mitochondrion for assembly in their final destination, but whether coexisting cardiovascular risk factors modulate this process is unknown. We hypothesized that metabolic syndrome (MetS) modulates mitochondrial protein import in porcine MSCs. MSCs were isolated from porcine abdominal adipose tissue after 16 weeks of Lean or MetS diet (n = 5 each)...
October 18, 2018: Stem Cell Reviews
Thomas Reinehr, Christian Ludwig Roth
PURPOSE OF REVIEW: Chronic inflammation, adipokines, and hepatokines have been identified as basis of insulin resistance and β cell failure in animal models. We present our current knowledge concerning the potential relationship between these cytokines, inflammation, metabolic syndrome (MetS), and type 2 diabetes mellitus (T2DM) in the pediatric population. RECENT FINDINGS: Pro-inflammatory cytokines related to insulin resistance and MetS in children are tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A...
October 18, 2018: Current Diabetes Reports
F Akram, D Fuchs, M Daue, G Nijjar, A Ryan, M E Benros, O Okusaga, E Baca-Garcia, L A Brenner, C A Lowry, K A Ryan, M Pavlovich, B D Mitchell, S Snitker, T T Postolache
Objectives: Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods: Fasting nitrite levels were measured in 116 Old Order Amish (78% women)...
October 2018: Obesity Science & Practice
Fernanda Pedrotti Moreira, Karen Jansen, Taiane de A Cardoso, Thaíse C Mondin, Pedro V Magalhães, Flavio Kapczinski, Luciano D M Souza, Ricardo A da Silva, Jean Pierre Oses, Carolina D Wiener
OBJECTIVE: To identify the association of metabolic syndrome (MetS) and psychiatric disorders in young adults in southern Brazil. METHODS: This population based cross-sectional study involved a total of 1,023 young adults between the ages of 21 and 32 years. Current episodes of psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview - Plus version. MetS was evaluated using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III)...
October 11, 2018: Revista Brasileira de Psiquiatria
Rawan Mohammad Al Saudi, Violet Kasabri, Randa Naffa, Nailya Bulatova, Yasser Bustanji
Background: The aim of the study was to compare and correlate glycated high-density lipoprotein (GHDL-C) and glycated low-density lipoprotein (GLDL-C) plasma levels with adiposity indices [weight/hip ratio (WHR) and body adiposity index (BAI)], lipid ratios and hematological indices [platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR)]. Methods: This was a cross-sectional study of 30 nondiabetic metabolic syndrome (MetS) patients, 30 prediabetic or type 2 diabetes mellitus (T2DM) patients and 30 normoglycemic controls...
October 2018: Therapeutic Advances in Endocrinology and Metabolism
Qutaiba Qusay Al-Heety, Violet Kasabri, Amal Akour, Randa Naffa, Samar Abu Rkhaya
Background: Paraoxonase 1 (PON1) and soluble intercellular adhesion molecule-1(sICAM-1) are intricately involved in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. This study aimed to investigate PON1 and sICAM-1 plasma levels in addition to correlating them with adiposity, atherogenicity and hematological indices in T2DM and MetS. Methods: This cross-sectional study composed of 28 healthy lean subjects (control), 29 normoglycemic MetS subjects and 30 MetS-Pre/T2DM...
October 2018: Therapeutic Advances in Endocrinology and Metabolism
Emre Bora, Roger S McIntyre, Aysegul Ozerdem
BACKGROUND: Individuals with bipolar disorder (BD) have a higher prevalence of obesity and metabolic syndrome (MetS) compared with the general population. Obesity and MetS are associated with cognitive deficits and brain imaging abnormalities in the general population. Obesity and components of MetS might potentially associate with neuroimaging and neurocognitive findings in BD. METHODS: A literature search of studies investigating the association between obesity (and other components of MetS) and neurocognitive and neuroimaging findings in BD was conducted...
October 17, 2018: Psychological Medicine
Anawin Sanguankeo, Sikarin Upala
Context: Metabolic syndrome (MetS) is documented to increase the risk of mortality in the general population. However, there are reports of lower mortality in end stage renal disease (ESRD) patients with obesity. Since obesity is a major component of MetS, this meta-analysis was conducted to determine the risk of all-cause mortality, cardiovascular disease (CVD) mortality, and cardiovascular disease events (CVE) associated with MetS in ESRD subjects. Evidence Acquisition: Eligible studies from inception to March 2017 assessing the clinical outcome of MetS in ESRD subjects were comprehensively searched in MEDLINE, EMBASE, and CENTRAL...
April 2018: International Journal of Endocrinology and Metabolism
Karrie M Butler, Joyce S Ramos, Christina A Buchanan, Lance C Dalleck
Purpose: The high prevalence of metabolic syndrome (MetS), prediabetes, and increased risk of cardiovascular diseases linked with prolonged sitting has created a need to identify options to limit sedentary behaviors. A potentially simple approach to achieve this goal in the university setting is to provide students the option to stand during courses rather than sit. The purpose of the present study was to examine the effects of standing in the college classroom setting on cardiometabolic risk factors in a cohort of college students...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Silvia Moreno-Fernández, Marta Garcés-Rimón, Gema Vera, Julien Astier, Jean François Landrier, Marta Miguel
Metabolic syndrome (MetS) is defined as a constellation of many metabolic disorders such as hypertension, impaired glucose tolerance, dyslipidemia and obesity, being this last disorder a key factor in the etiology of the syndrome. The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast. The main objective of the present study was to evaluate the MetS-associated alterations developed in a new glucose diet-induced-obesity (DIO) rodent model...
October 14, 2018: Nutrients
Miaomiao Zhao, David Chiriboga, Barbara Olendzki, Bin Xie, Yawen Li, Lisa Jo McGonigal, Ana Maldonado-Contreras, Yunsheng Ma
The American Heart Association (AHA) dietary guidelines recommend 30⁻35% of energy intake (%E) be from total fat, <7%E from saturated fatty acids (SFA), and <1%E from trans fatty acid (TFA). This study evaluates the effect of AHA dietary counselling on fat intake. Between 2009 and 2014, 119 obese adults with metabolic syndrome (MetS), (71% women, average 52.5 years of age, and 34.9 kg/m² of body mass index), received individual and group counselling on the AHA diet, over a one-year study period. Each participant attended 2 individual sessions (months 1 and 12) and 12 group sessions, at one-month intervals...
October 12, 2018: Nutrients
Nicolle Kränkel, Martin Bahls, Emeline M Van Craenenbroeck, Volker Adams, Luis Serratosa, Erik Ekker Solberg, Dominique Hansen, Marcus Dörr, Hareld Kemps
Metabolic syndrome (MetS) - a clustering of pathological conditions, including abdominal obesity, hypertension, dyslipidemia and hyperglycaemia - is closely associated with the development of type 2 diabetes mellitus (T2DM) and a high risk of cardiovascular disease. A combination of multigenetic predisposition and lifestyle choices accounts for the varying inter-individual risk to develop MetS and T2DM, as well as for the individual amount of the increase in cardiovascular risk in those patients. A physically active lifestyle can offset about half of the genetically mediated cardiovascular risk...
October 15, 2018: European Journal of Preventive Cardiology
Mauro Finicelli, Tiziana Squillaro, Francesca Di Cristo, Anna Di Salle, Mariarosa Anna Beatrice Melone, Umberto Galderisi, Gianfranco Peluso
Metabolic syndrome (MetS) is defined as the co-occurrence of metabolic risk factors that includes insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and visceral obesity. The clinical significance of MetS consists of identifying a subgroup of patients sharing a common physiopathological state predisposing to chronic diseases. Clinical and scientific studies pinpoint lifestyle modification as an effective strategy aiming to reduce several features accountable for the risk of MetS onset...
October 14, 2018: Journal of Cellular Physiology
K-M Lee, M-C Lee, C-J Lee, Y-C Chen, B-G Hsu
BACKGROUND: Low levels of natriuretic peptide may activate the renin-angiotensin-aldosterone system, which may contribute to the development of obesity. Therefore, in study we aim to evaluate the relationship between metabolic syndrome (MetS) and serum N-terminal pro‒B-type natriuretic peptide (NT-proBNP) concentration in kidney transplant recipients. METHODS: Fasting blood samples were obtained from 66 kidney transplant recipients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation...
October 2018: Transplantation Proceedings
Han Shen, Jing Lu, Ting-Ting Shi, Cheng Cheng, Jing-Yi Liu, Jian-Ping Feng, Jin-Kui Yang
Serum alanine aminotransferase (ALT) is a biomarker of hepatocyte damage. However, the relationship between normal range of serum ALT level and metabolic syndrome (MetS) has not been completely understood. This study aimed to investigate the correlation between normal range of serum ALT level and MetS.A total of 2453 participants from the Beijing Community Pre-Diabetes study were enrolled. Multiple linear regression analysis was performed to calculate the regression coefficient. Normal serum ALT levels were divided into quartiles...
October 2018: Medicine (Baltimore)
Mei-Zhen Yuan, Qin Fang, Guang-Wei Liu, Min Zhou, Jian-Mei Wu, Chun-Yun Pu
BACKGROUND: The incidence of depression is very common among patients with post-acute coronary syndrome (ACS) and leads to adverse outcomes. AIMS: The aim of this meta-analysis was to detect risk factors for depression among patients with ACS and to provide clinical evidence for its prevention. METHODS: The authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline to search the PubMed, Web of Science, EMBASE, and EBSCO databases from January 1996 to March 2018...
October 11, 2018: Journal of Cardiovascular Nursing
Renato Casana, Chiara Malloggi, Valerio Stefano Tolva, Andrea Odero, Richard Bulbulia, Alison Halliday, Vincenzo Silani
AIMS: The metabolic syndrome (MetS) is composed of a cluster of related cardiovascular risk factors. The aim of the present study was to determine how MetS contributes to short- (30-day) and long-term complications and restenosis after carotid endarterectomy (CEA) or stenting (CAS). METHODS: A consecutive cohort of 752 patients undergoing CEA (n = 314) and CAS (n = 438) in a single institution were examined, of which 296 (39.4%) were identified as having MetS. All patients were followed-up with carotid duplex ultrasound scan of the supraaortic vessels and a neurological assessment of symptoms status at 30 days post-procedure and at 3, 6 and 12 months, with annual follow-up thereafter for 3 years...
October 12, 2018: Diabetes/metabolism Research and Reviews
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