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GI intervention

Kelly Makielski, Jonah Cullen, Annette O'Connor, Albert E Jergens
BACKGROUND: The optimal medical treatment for chronic enteropathy (CE) in dogs and cats is controversial. Sequential treatment using diet, antimicrobials, and immunosuppressive drugs is the most common strategy used by clinicians. OBJECTIVES: To review the evidence for the effectiveness of dietary, drug, and alternative health interventions for inducing clinical remission in dogs and cats with CE. ANIMALS: Retrospective study of dogs and cats with a diagnosis of chronic enteropathy...
December 6, 2018: Journal of Veterinary Internal Medicine
Alejandra Vilanova-Sánchez, Carlos Albert Reck, Richard J Wood, Cristina Garcia Mauriño, Alessandra C Gasior, Robert E Dyckes, Katherine McCracken, Laura Weaver, Devin R Halleran, Karen Diefenbach, Dennis Minzler, Rebecca M Rentea, Christina B Ching, Venkata Rama Jayanthi, Molly Fuchs, Daniel Dajusta, Geri D Hewitt, Marc A Levitt
Aim of the study: Many patients with an anorectal malformation (ARM) or pelvic anomaly have associated urologic or gynecologic problems. We hypothesized that our multidisciplinary center, which integrates pediatric colorectal, urologic, gynecologic and GI motility services, could impact a patient's anesthetic exposures and hospital visits. Methods: We tabulated during 2015 anesthetic/surgical events, endotracheal intubations, and clinic/hospital visits for all patients having a combined procedure. Main results: Eighty two patients underwent 132 combined procedures (Table 1)...
2018: Frontiers in Surgery
Philipp Wurm, Elisabeth Dörner, Christina Kremer, Julia Spranger, Cynthia Maddox, Bettina Halwachs, Ute Harrison, Thomas Blanchard, Rainer Haas, Christoph Högenauer, Gregor Gorkiewicz, W Florian Fricke
Clinical interventions in the stomach have been linked to fecal microbiota alterations, suggesting a function of the stomach in gastrointestinal (GI) homeostasis. We sought to determine the taxonomic bacterial biogeography of the upper GI tract, including different sites within the human stomach (cardia, corpus, and antrum), adjacent upstream (esophagus) and downstream (duodenum) locations, and luminal contents (aspirate), as well as whole-stomach samples from mice and gerbils. Qualitative and quantitative DNA- and RNA-based taxonomic microbiota analyses were combined to study the relationship of relative and absolute bacterial abundances and transcriptionally active bacterial microbiota components in the stomach of humans and mice...
November 2018: MSystems
Stephen J Chapman, Joe Garner, Thomas M Drake, Mohammed Aldaffaa, David G Jayne
BACKGROUND: The management of delayed GI recovery after surgery is an unmet challenge. Uncertainty over its pathophysiology has limited previous research, but recent evidence identifies intestinal inflammation and activation of µ-opioid receptors as key mechanisms. Nonsteroidal anti-inflammatory drugs are recommended by enhanced recovery protocols for their opioid-sparing and anti-inflammatory properties. OBJECTIVES: The purpose of this study was to explore the safety and efficacy of nonsteroidal anti-inflammatory drugs to improve GI recovery and to identify opportunities for future research...
November 26, 2018: Diseases of the Colon and Rectum
Daryl Ramai, Andrew Ofosu, Jameel Singh, Febin John, Madhavi Reddy, Douglas Adler
INTRODUCTION: Ampullary cancer accounts for only 0.2% of GI cancers. The objective of this study was to investigate the incidence, demographics, tumor characteristics, treatment, and survival of patients with ampullary tumors. METHODS: Data on ampullary cancer between 2004 and 2013 was extracted from the Surveillance, Epidemiology and End Results (SEER) Registry. The clinical epidemiology of these tumors was analyzed using SEER*Stat. RESULTS: A total of 6803 patients with ampullary cancer were identified...
November 27, 2018: Minerva Gastroenterologica e Dietologica
Minji K Lee, Kathleen J Yost, Karlyn E Pierson, Amy J Schrandt, Bobbie J Skaare, Shanda H Blackmon
BACKGROUND: The purpose of this study was to establish the clinical thresholds for five domains (dysphagia, reflux, dumping-hypoglycemia, dumping-GI symptoms, pain) to support the use of the CONDUIT questionnaire as a screening tool to identify patients who might benefit from an educational or clinical intervention. METHODS: A panel of 16 experts met to develop descriptions of "poor," "moderate," and "good" conduit performance. They were trained to use the modified and extended Angoff standard-setting method...
October 24, 2018: Journal of patient-reported outcomes
Bo Shen, Gursimran Kochhar, Tracy L Hull
No abstract text is available yet for this article.
November 21, 2018: American Journal of Gastroenterology
M I Zafar, K E Mills, J Zheng, M M Peng, X Ye, L L Chen
OBJECTIVES: Low glycaemic index (GI) diets may aid in weight loss by reducing postprandial blood glucose excursions, leading to more stable blood glucose concentrations and therefore a reduction in hunger. To test this hypothesis, we conducted a systematic review and meta-analysis of randomized controlled trials comparing low GI diets with other diet types. METHODS: We included 101 studies involving 109 study arms and 8,527 participants. We meta-analysed the studies using a random-effects model and conducted subgroup analyses and meta-regression based on control diet, blood glucose control, baseline BMI and dietary GI...
November 20, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Carmen Olmedo Lucerón, Ana María Pérez Meixeira, Andrés Iriso Calle, Emiliano Aránguez Ruiz, Isabel Abad Sanz
OBJECTIVE: Leishmaniasis is a zoonotic disease, widely spread all over the world, and an endemic disease in some Spanish regions. Within the Autonomous Region of Madrid, some south populations were affected by an outbreak from 2009. This outbreak had special features and implications related to epidemiology, reservoir and environment intervention. An increased rate in rural areas bordering the outbreak area was detected by epidemiological surveillance. This area has the same environment characteristics...
November 20, 2018: Revista Española de Salud Pública
Yassmin Mansela Musthaffa, Vikas Goyal, Margaret-Anne Harris, Nitin Kapur, Juliane Leger, Mark Harris
Background Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic control. A hypoglycaemic seizure in a 4-year-old girl with CCHS led to a more detailed examination of glycaemic control in a cohort of children with CCHS. Methods We conducted an observational cohort study of glucose homeostasis in seven children (3 months to 12 years) with genetically confirmed CCHS using a combination of continuous glucose monitoring (CGM), fasting studies and oral glucose tolerance test (OGTT). CGM was used to compare the effect of diazoxide and dietary intervention in the index patient...
November 17, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Zsuzsanna H McMahan, Tracy Frech, Veronica Berrocal, David Lim, Cosimo Bruni, Marco Matucci-Cerinic, Vanessa Smith, Karin Melsens, Susanna Proudman, Jinyu Zhang, Fabian Mendoza, Melanie Woods, Dinesh Khanna
OBJECTIVE: Validated gastrointestinal (GI) symptoms scales are used in clinical practice to assess patient-reported GI involvement. We sought to determine whether University of California, Los Angeles (UCLA) GI Tract Questionnaire (GIT) 2.0 Reflux scale, Patient-Reported Outcomes Measurement Information System (PROMIS) Reflux scale, and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) are sensitive to identifying changes in GI symptoms following therapeutic intervention in participants with systemic sclerosis (SSc) and gastroesophageal reflux disease (GERD)...
November 15, 2018: Journal of Rheumatology
Xiao-Li Li, Ming-Yu Liu, Liang Cheng, Hong-Fei Zhu, Dan Cui
PURPOSE: To assess the impact of oral health promotion project on periodontal condition and life quality of the elderly in long-term care institutions. METHODS: Elder people from 5 nursing homes in Wuhan city were selected and assigned to either the experimental group or the control group by random cluster grouping method. A six-month oral health promotion project was provided to the experimental group. The changes of geriatric oral health assessment index (GOHAI), oral hygiene index-simplified (OHI-S), gingival index (GI), bleeding on probing (BOP) and probing depth (PD) were compared with student's t test and repetitive measure analysis of variance using SPSS21...
June 2018: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Lin-Hai Yan, Zhi-Ning Chen, Chun-Jun Li, Jia Chen, Yu-Zhou Qin, Jian-Si Chen, Wei-Zhong Tang
Background: Imatinib has been regarded as the first successful synthetic small molecule targeting at blocking tyrosine kinase. Its high efficacy stabilized disease in above 80% of chronic myeloid leukemia (CML) patients over 10 years survival. Due to the similar canceration of gastrointestinal stromal tumor (GIST) as to CML, imatinib has been approved to be used as first-line treatment. Study design: Our retrospective study was proposed to enroll 191 GIST patients with larger tumor size (≥8 cm) who preoperative accepted imatinib from those with direct operation...
2018: Journal of Cancer
Emily Neuhaus, Raphael A Bernier, See Wan Tham, Sara J Webb
Individuals with autism spectrum disorder (ASD) are at heightened risk of psychiatric comorbidities across the lifespan, including elevated rates of internalizing, externalizing, and self-injurious behaviors. Identification of medical comorbidities that contribute to these concerns may elucidate mechanisms through which psychiatric concerns arise, as well as offer additional avenues for intervention. Gastrointestinal (GI) conditions are of particular interest, as they are prevalent among those with ASD, may share genetic or neurobiological etiologies with the core features of ASD, and are linked with psychiatric difficulties in the general population...
2018: Frontiers in Psychiatry
Rui Manuel Rodrigues Pereira, Niedje Siqueira, Edna Costa, Dione do Vale, Nivaldo Alonso
BACKGROUND: Adequate dentofacial growth is an objective of unilateral cleft lip and palate treatment. No study exists, comparing the dental arch of 5-year-old relationship after 2 treatment protocols: one with single-stage palatoplasty and another with delayed hard palate closure (DHPC). The authors hypothesized that the DHPC protocol provides better dentofacial growth. METHODS: A single-center, single-surgeon Randomized Clinical Trial was performed to evaluate the maxillomandibular relationships in 2 groups...
September 2018: Journal of Craniofacial Surgery
Bo Shen, Gursimran Kochhar, Udayakumar Navaneethan, Xiuli Liu, Francis A Farraye, Yago Gonzalez Lama, David Bruining, Darrell S Pardi, Martin Lukas, Martin Bortlik, Kaicun Wu, Ajit Sood, David A Schwartz, William J Sandborn
Interventional (or therapeutic) inflammatory bowel disease (IBD) endoscopy has an expanding role in the treatment of disease and surgical adverse events. Endoscopic therapy has been explored and used in the management of strictures, fistulas/abscesses, colitis-associated neoplasia, post-surgical acute or chronic leaks, and obstructions. The endoscopic therapeutic modalities include balloon dilation, stricturotomy, stent placement, fistulotomy, fistula injection and clipping, sinusotomy, endoscopic mucosal resection, and endoscopic submucosal dissection...
October 23, 2018: Gastrointestinal Endoscopy
Derek Richards
Data sourcesPubMed, the Cochrane Library and Web of Science databases.Study selectionRandomised controlled trials (RCTs) providing information on the effectiveness of oral sprays on plaque or gingival inflammation and published in English were considered.Data extraction and synthesisTwo reviewers independently screened the studies, abstracted data and assessed risk of bias using the Cochrane tool. Disagreements were resolved by discussion and consensus. Estimates from suitable studies were pooled using a random effects meta-analysis...
October 2018: Evidence-based Dentistry
Yi-Hua Lee, Gi-Ming Lai, De-Chih Lee, Lee-Jang Tsai Lai, Yuan-Ping Chang
OBJECTIVES: Cancer-related fatigue and fear of recurrence (FOR) are the most common symptoms in cancer survivors and severely affect quality of life (QOL). This study aims to promote and evaluate the effectiveness of physical and psychological rehabilitation activities for cancer survivors. METHODS: A longitudinal study with an interventional research design was conducted. A total of 80 participants were randomly assigned to experimental groups E1 (Qigong exercise [QE]) or E2 (stress management [SM]) or the control group...
December 2018: Integrative Cancer Therapies
Małgorzata Woźniewicz, Paulina M Nowaczyk, Anna Kurhańska-Flisykowska, Marzena Wyganowska-Świątkowska, Małgorzata Lasik-Kurdyś, Jarosław Walkowiak, Joanna Bajerska
Periodontal disease is highly prevalent worldwide, and consumption of certain foods, such as fruits, seem to improve the effectiveness of periodontal therapy (PT) due to their antiadhesive, immunomodulatory, and antioxidative properties. We hypothesized that the cranberry functional beverage (CFB) consumed for eight weeks improves gingival inflammation indices via inhibition of dental plaque, and alterations in antioxidant status, and systemic inflammation in patients with gingivitis. In this two-arm randomized controlled study, fifty participants were divided into an experimental group (CFB), administered daily with 750 ml CFB, or a control group administered the same amount of water...
October 2018: Nutrition Research
Bruce A Griffin, Celia G Walker, Susan A Jebb, Carmel Moore, Gary S Frost, Louise Goff, Tom A B Sanders, Fiona Lewis, Margaret Griffin, Rachel Gitau, Julie A Lovegrove
We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial ('RISCK' study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of high or low glycaemic index (GI) on CVD risk factors and insulin sensitivity. We tested the impact of APOE genotype (carriage of E2 and E4 alleles versus E3/E3), determined retrospectively, on plasma lipids, lipoproteins and glucose homeostasis at baseline ( n = 469), and on the change in these variables after 24 weeks of dietary intervention ( n = 389)...
October 17, 2018: Nutrients
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