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Aya Yatsugi, Takashi Morishita, Hiroyuki Fukuda, Naoya Kotani, Kenji Yagi, Hiroshi Abe, Etsuji Shiota, Tooru Inoue
Recent studies of robotic rehabilitation have demonstrated its efficacy for neurological disorders. However, few studies have used the Hybrid Assistive Limb (HAL) during the early postoperative stage of spine disorders. We aimed to evaluate the safety and efficacy of HAL treatment during the early postoperative period for spine disorder patients. We retrospectively identified patients who underwent spine surgery and who could complete HAL treatment. We evaluated the 10-m walking test (10MWT), the modified Gait Abnormality Rating Scale (GARS-M), Barthel Index (BI), and the walking index for spinal cord injury II (WISCI II) score results before and after robotic rehabilitation...
2018: Applied Bionics and Biomechanics
Gar W Rothwell, Ignacio H Escapa, Alexandru M F Tomescu
No abstract text is available yet for this article.
August 16, 2018: American Journal of Botany
Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan N Thung, Augusto Villanueva, Carol Pena, Gerold Meinhardt, Jordi Bruix, Josep M Llovet
OBJECTIVE: Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma (HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70% 5-year recurrence rates. The phase 3 STORM trial comparing sorafenib with placebo as adjuvant treatment did not achieve its primary endpoint of improving recurrence-free survival (RFS). The biomarker companion study BIOSTORM aims to define (A) predictors of recurrence prevention with sorafenib and (B) prognostic factors with B level of evidence...
August 14, 2018: Gut
Mingyue Li, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Clara Bik-San Lau
BACKGROUND: Curcumin, a well-studied component in turmeric, exhibits potent antitumor effects in colorectal cancer. Previous studies showed that turmerones raised the accumulation of curcumin inside colonic cells, and curcumin present in turmeric ethanolic extract had enhanced anti-tumor activities in mice. Metastasis accounts for more than 90% colorectal cancer deaths. However, the anti-metastatic effect of turmeric extract on colorectal cancer is still unknown. METHODS: In the present study, colony formation, scratch, transwell and Western blot were used to assess colony formation, motility, migration and underlying mechanisms in vitro, respectively...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Xueying Yu, Bin Chen, Hefei Tang, Wei Li, Ying Fu, Zaiqiang Zhang, Yaping Yan
Glycyl-tRNA synthetase ( GARS) gene mutations have been reported to be associated with Charcot-Marie-Tooth disease 2D and distal hereditary motor neuropathy type V (dHMN-V). In this study, we report a novel GARS mutation in a Chinese family with dHMN-V. Clinical, electromyogram, genetic, and functional data were explored. The proband was an 11-year-old girl presented with progressive distal limb muscle weakness and atrophy due to peripheral motor neuropathy for 1 year. Another five members from three successive generations of the family showed similar symptoms during their first to second decades and demonstrated an autosomal dominant inheritance...
2018: Frontiers in Neurology
Melinda Randall, Kristine J Egberts, Aarti Samtani, Rob Jpm Scholten, Lotty Hooft, Nuala Livingstone, Katy Sterling-Levis, Susan Woolfenden, Katrina Williams
BACKGROUND: Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In recent years, especially following publication of the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5; APA 2013), children are given the diagnosis of ASD, rather than subclassifications of the spectrum such as autistic disorder, Asperger syndrome, or pervasive developmental disorder - not otherwise specified...
July 24, 2018: Cochrane Database of Systematic Reviews
Ichiro Sasagawa, Mikio Ishiyama, Hiroyuki Yokosuka, Masato Mikami, Shunya Oka, Hitoyata Shimokawa, Takashi Uchida
Enameloid is a well-mineralized tissue covering the tooth surface in fish and it corresponds to the outer-most layer of dentin. It was reported that both dental epithelial cells and odontoblasts are involved in the formation of enameloid. Nevertheless, the localization and timing of secretion of ectodermal enamel matrix proteins (EMPs) in enameloid are unclear. In the present study, the enameloid matrix during the stages of enameloid formation in spotted gar, Lepisosteus oculatus, an actinopterygian, was examined mainly by transmission electron microscopy-based immunohistochemistry using an anti-mammalian amelogenin (AMEL) antibody and antiserum...
July 31, 2018: Connective Tissue Research
Marcel Schulz, Adrian Gehl, Jakob Schlenkrich, Hendrik Albert Schulze, Stefan Zimmermann, Andreas Schaate
A calixarene-based metal-organic framework (Zr-cal,[Zr6O4(OH)4(FA)6]2(cal)3], FA=formate, cal=1,3-alt-25,26,27,28-Tetrakis-[(carboxy)methoxy]-calixarene) was synthesized and its structure was characterized with single-crystal X-ray diffraction. The three-dimensional framework is a 4,6-connected network of gar topology and exhibits two equal but nonintersecting three-dimensional pore systems. It has a specific BET surface area of 670 m2 g-1 and the calixarene linkers are accessible through the pore systems. The exposed calixarene can be used for the visual detection and encapsulation of NO2 by forming deeply colored charge transfer complexes inside the MOF...
July 20, 2018: Angewandte Chemie
Andrés Elgorriaga, Ignacio H Escapa, Gar W Rothwell, Alexandru M F Tomescu, N Rubén Cúneo
PREMISE OF THE STUDY: Equisetum is the sole living representative of Sphenopsida, a clade with impressive species richness, a long fossil history dating back to the Devonian, and obscure relationships with other living pteridophytes. Based on molecular data, the crown group age of Equisetum is mid-Paleogene, although fossils with possible crown synapomorphies appear in the Triassic. The most widely circulated hypothesis states that the lineage of Equisetum derives from calamitaceans, but no comprehensive phylogenetic studies support the claim...
July 19, 2018: American Journal of Botany
Petra C Siemonsma, Jeanet W Blom, Hedwig Hofstetter, Ariëtte T H van Hespen, Jacobijn Gussekloo, Yvonne M Drewes, Nico L U van Meeteren
BACKGROUND: A physically active lifestyle in older people contributes to the preservation of good health. We assessed the influence of physiotherapy on daily functioning among community dwelling older people (75+) with complex health problems identified with screening, versus usual care. We also compared functional task exercise (FTE), with problems prioritized by older people, trained in the home environment, versus usual preventive physical therapy (PPT). METHODS: Design: FTE and PPT were compared in a randomized controlled trial (RCT)...
July 17, 2018: BMC Geriatrics
Jolin Wong, John Song En Lee, Theodore Gar Ling Wong, Rehana Iqbal, Patrick Wong
Since the first use of the flexible fibreoptic bronchoscope, a plethora of new airway equipment has become available. It is essential for clinicians to understand the role and limitations of the available equipment to make appropriate choices. The recent 4th National Audit Project conducted in the United Kingdom found that poor judgement with inappropriate choice of equipment was a contributory factor in airway morbidity and mortality. Given the many modern airway adjuncts that are available, we aimed to define the role of flexible fibreoptic intubation in decision-making and management of anticipated and unanticipated difficult airways...
July 16, 2018: Singapore Medical Journal
Daniel Lozano, Agustín González, Jesús M López
Holosteans form a small group of actinopterygian fishes considered the sister group of teleosts. Despite this proximity to the biggest group of vertebrates, relatively few studies have been conducted to investigate the organization of the central nervous system of this group of fishes. In this study, the neuroanatomical distribution of orexin/hypocretin-like immunoreactive (OX-ir) cell bodies and fibers was analyzed in the brain of 3 representative species of the 2 orders of extant holosteans, the spotted gar Lepisosteus oculatus, the Florida gar Lepisosteus platyrhincus, and the bowfin Amia calva...
July 13, 2018: Brain, Behavior and Evolution
Gar W Rothwell, Michael A Millay, Ruth A Stockey
PREMISE OF THE STUDY: Recent clarification of the distribution of Marattiales through time provides the impetus for "total evidence" phylogenetic analyses of a major fern clade with a rich fossil record. These analyses serve as empirical tests for results from systematic analyses of living species and also of the belief that relationships among living species accurately reflect the overall pattern of phylogeny for clades with an extensive fossil record and a large percentage of extinction...
July 12, 2018: American Journal of Botany
Alan J Rogers, Gar-Hing A Lee, Peter Boan
No abstract text is available yet for this article.
July 16, 2018: Medical Journal of Australia
Chung-Yu Chang, Wei-Yao Hsieh, Gar-Yang Chau, Ping-Hsien Chen, Chien-Wei Su, Ming-Chih Hou, Hao-Jan Lei, Teh-Ia Huo, Yi-Hsiang Huang, Han-Chieh Lin, Jaw-Ching Wu
OBJECTIVE: The predictive value of esophageal varices (EV) in determining the patient outcome in hepatocellular carcinoma (HCC) remains unresolved. We aimed to assess the impact of EV on the prognosis of HCC patients after surgical resection. MATERIALS AND METHODS: We consecutively enrolled 446 treatment-naive HCC patients who underwent surgical resection and esophagogastroduodenoscopy from 2003 to 2015. Prognostic factors were analyzed using the Cox proportional hazards model and a propensity score matching analysis...
July 9, 2018: European Journal of Gastroenterology & Hepatology
Hanaa Mahmoud Ali
BACKGROUND: Lead acetate (Led) and mercury chloride (Mer) represent important ecological and public health concerns due to their hazardous toxicities. Naturally found products play a vital role in chemopreventive agent innovation. The current study aimed to assess the modifying effect of garlic (Gar) and/or vitamin E (Vit E) against the half-maximal inhibitory concentration (IC50) Led and/or Mer-induced cytotoxic, genotoxic and apoptotic effects. METHODS: Human lung cells (WI-38) were pretreated with Gar and/or Vit E for 24 h and then treated with Led and/or Mer either alone or with their combination for 24 h...
February 5, 2018: Pharmacological Reports: PR
Anna Oda, Michaela Hynie, Andrew Tuck, Branka Agic, Brenda Roche, Kwame McKenzie
Between November 2015 and January 2017, the Government of Canada resettled over 40,000 Syrian refugees through different sponsorship programs (GAR and PSR). Timely access to healthcare is essential for good health and successful integration. However, refugee support differs depending on sponsorship program, which may lead to differences in healthcare service access and needs. A cross-sectional study with a sample of Syrian refugees was conducted to assess healthcare access, and perceived physical and mental health status...
June 29, 2018: Journal of Immigrant and Minority Health
Anne-Lene Kjældgaard, Katrine Pilely, Karsten Skovgaard Olsen, Stephen Wørlich Pedersen, Anne Øberg Lauritsen, Kirsten Møller, Peter Garred
Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the last decade, basic research within the innate immune system, and in particular the complement system, has revealed new, important roles of the innate immune system during development, homeostasis, and ageing within as well as outside the central nervous system...
June 19, 2018: Molecular Immunology
Naoko Takezaki
This study investigated long-term substitution rate differences using three calibration points, divergences between lobe-finned vertebrates and ray-finned fish, between mammals and sauropsids, and between holosteans (gar and bowfin) and teleost fish with amino acid sequence data of 625 genes for 25 bony vertebrates. The result showed that the substitution rate was two to three times higher in the stem branches of lobe-finned vertebrates before the mammal-sauropsid divergence than in amniotes. The rate in the stem branch of ray-finned fish before the holostean-teleost fish divergence was also a few times higher than the holostean rate, whereas it was similar to or somewhat slower than the teleost fish rate...
July 1, 2018: Genome Biology and Evolution
Yuzuru Satake, Yuki Kuwano, Tatsuya Nishikawa, Kinuyo Fujita, Saki Saijo, Miki Itai, Hiroki Tanaka, Kensei Nishida, Kazuhito Rokutan
Transcribed-ultraconserved regions (T-UCRs), which contain conserved sequences with 100% identity across human, rat and mouse species, are a novel category of functional RNAs. The human transformer 2β gene ( TRA2B ) encodes a UCR that spans exon 2 (276 bp) and its neighboring introns. Among five spliced RNA variants ( TRA2β1-5 ) transcribed from the TRA2B gene, only TRA2β4 contains the conserved exon 2. TRA2β4 is overexpressed in colon cancer cells and accelerates cell growth by blocking the transcription of CDKN1A ...
June 1, 2018: Oncotarget
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