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Michi Recupero, Pierluigi Fulignati, Alessandro Naticchia, Silvia D'Alonzo, Francesca D'Ascenzo, Stefano Costanzi
ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. By inhibiting the activation pathway of vasopressin, they are potentially useful in euvolemic and hypervolemic hypotonic hyponatremia...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Michael A Bohl, Randall J Hlubek, Michael A Mooney, Kristina M Chapple, Mark C Preul, Steve W Chang, Jay D Turner, U Kumar Kakarla
BACKGROUND: Posterior column osteotomy (PCO) is a powerful technique for correcting lordosis, but the surgical literature lacks objective evidence on preoperative predictors of achievable lordotic correction following PCO. OBJECTIVE: To measure the correlation between disc geometry and achievable lordotic correction following Schwab grade 2 osteotomies and to describe geometric changes to disc space following lordotic correction. METHODS: Schwab grade 2 osteotomies were performed from T1 to S1 in 5 cadavers...
December 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
Ji Liu, Zhi Li
Alcohol dehydrogenase (ADH) and amine dehydrogenase (AmDH)-catalyzed one-pot cascade conversion of an alcohol to an amine provides a simple preparation of chiral amines. To enhance the cofactor recycling in this reaction, we report a new concept of coupling whole-cells with cell-free system to enable separated intra- and extra-cellular cofactor regeneration and recycling. This was demonstrated by the respective biotransformation of racemic 4-phenyl-2-butanol 1a and 1-phenyl-2-propanol 1b to (R)-4-phenylbutan-2-amine 3a and (R)-1-phenylpropan-2-amine 3b...
December 8, 2018: Biotechnology and Bioengineering
P Thakore, A E Dunbar, E B Lindsay
A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. On the day of life 29, a gradual increase in serum sodium level refractory to increasing total fluid volume was noted...
December 1, 2018: Journal of Neonatal-perinatal Medicine
Jonathan Lo, Tianyong Zheng, Shuen Hon, Daniel G Olson, Lee R Lynd
No abstract text is available yet for this article.
January 1, 2019: Journal of Bacteriology
Xiaopan Yang, Kunling Teng, Rina Su, Lili Li, Tong Zhang, Keqiang Fan, Jie Zhang, Jin Zhong
Lactobacillus plantarum is a kind of versatile bacteria that occupies a wide range of environmental niches. In this study, we found a bifunctional aldehyde-alcohol dehydrogenase encoding gene adhE was responsible for L. plantarum to utilize mannitol and sorbitol through cross-regulation by two DNA-binding regulators. In L. plantarum NF92, adhE was greatly induced and the growth of adhE disrupted strain (ΔadhE) was repressed when sorbitol or mannitol instead of glucose was used as carbon source. The results of enzyme activity and metabolite assay demonstrated that AdhE could catalyze the synthesis of ethanol in L...
December 7, 2018: Applied and Environmental Microbiology
Christoph J Rageth, Elizabeth A M O'Flynn, Katja Pinker, Rahel A Kubik-Huch, Alexander Mundinger, Thomas Decker, Christoph Tausch, Florian Dammann, Pascal A Baltzer, Eva Maria Fallenberg, Maria P Foschini, Sophie Dellas, Michael Knauer, Caroline Malhaire, Martin Sonnenschein, Andreas Boos, Elisabeth Morris, Zsuzsanna Varga
PURPOSE: The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations. METHODS: This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy. RESULTS: In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years...
November 30, 2018: Breast Cancer Research and Treatment
Krishna Adit Agarwal, Myat Han Soe
We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC...
2018: Case Reports in Oncological Medicine
Diana Ovejero, Barbara M Misof, Rachel I Gafni, David Dempster, Hua Zhou, Klaus Klaushofer, Michael T Collins, Paul Roschger
The role of the calcium-sensing receptor (CaSR) as a regulator of parathyroid hormone secretion is well established, but its function in bone is less well defined. In an effort to elucidate the CaSR's skeletal role, bone tissue and material characteristics from patients with autosomal dominant hypocalcemia (ADH), a genetic form of primary hypoparathyroidism caused by CASR gain-of-function mutations, were compared to patients with postsurgical hypoparathyroidism (PSH). Bone structure and formation/resorption indices and mineralization density distribution (BMDD), were examined in transiliac biopsy samples from PSH (n = 13) and ADH (n = 6) patients by histomorphometry and quantitative backscatter electron imaging, respectively...
November 29, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Monique Adakai, Michelle Sandoval-Rosario, Fang Xu, Teresa Aseret-Manygoats, Michael Allison, Kurt J Greenlund, Kamil E Barbour
Compared with other racial/ethnic groups, American Indians/Alaska Natives (AI/AN) have a lower life expectancy, lower quality of life, and are disproportionately affected by many chronic conditions (1,2). Arizona has the third largest population of AI/AN in the United States (approximately 266,000 in 2017), and is home to 22 federally recognized American Indian tribal nations.* The small AI/AN sample size in previous Behavioral Risk Factor Surveillance System (BRFSS) surveys has presented analytic challenges in making statistical inferences about this population...
November 30, 2018: MMWR. Morbidity and Mortality Weekly Report
Christoph Henzen
CME: Paraneoplastic Endocrine Syndromes Abstract. Paraneoplastic endocrine syndromes are caused by ectopic hormone production by malignant tumor cells. Knowledge of paraneoplastic endocrine syndromes may allow a timely diagnosis of the underlying cancer at a treatable stage and, on the other hand, appropriate treatment of the endocrine manifestations reduces morbidity and mortality of the affected patients. The most common endocrine syndromes are paraneoplastic hypercalcaemia, caused by the secretion of PTHrP, and hyponatremia, caused by the inadequate secretion of ADH...
November 2018: Praxis
Aimin Lv, Liantai Su, Xingchen Liu, Qiang Xing, Bingru Huang, Yuan An, Peng Zhou
BACKGROUND: Dehydrins play positive roles in regulating plant abiotic stress responses. The objective of this study was to characterize two dehydrin genes, CdDHN4-L and CdDHN4-S, generated by alternative splicing of CdDHN4 in bermudagrass. RESULTS: Overexpression of CdDHN4-L with φ-segment and CdDHN4-S lacking of φ-segment in Arabidopsis significantly increased tolerance against abiotic stresses. The growth phenotype of Arabidopsis exposed to NaCl at 100 mM was better in plants overexpressing CdDHN4-L than those overexpressing CdDHN4-S, as well as better in E...
November 26, 2018: BMC Plant Biology
Michael A Bohl, Randall J Hlubek, David S Xu, Claudio Cavallo, Mark C Preul, Steve W Chang, Jay D Turner, Juan S Uribe, U Kumar Kakarla
INTRODUCTION: Anterior column release is a powerful surgical technique for achieving spinopelvic balance in adult patients with sagittal plane deformities. We present an alternative strategy for focal deformity correction from a posterior-only approach. The purpose of this study was to evaluate the feasibility and efficacy of a novel surgical technique called posterior open-wedge diskectomy and anterior longitudinal ligament (ALL) release (POWAR). MATERIALS AND METHODS: A cadaveric torso underwent POWARs at the L1-L4 intervertebral disc spaces...
November 24, 2018: Clinical Anatomy
Naruhisa Yamaki, Sachio Matsushita, Sachiko Hara, Akira Yokoyama, Akitoyo Hishimoto, Susumu Higuchi
Heavy drinking leads to premature aging and precipitates the onset of age-related diseases. Acetaldehyde (AcH), a toxic metabolite of ethanol, has been implicated in various types of cancer. However, whether alcohol accelerates biological aging at a cellular level is controversial and the mechanism involved is unclear. We addressed these questions by measuring telomere length (TL) in peripheral blood leukocytes of Japanese patients with alcohol dependence (AD) and examined the association between TL, genetic variants of alcohol dehydrogenase (ADH)1B and aldehyde dehydrogenase (ALDH)2, and other clinical characteristics...
November 8, 2018: Journal of Psychiatric Research
Elena Diana Salagean, Elzbieta Slodkowska, Sharon Nofech-Mozes, Wedad Hanna, Carlos Parra-Herran, Fang-I Lu
BACKGROUND: Although the rate of carcinoma upgrade for atypical ductal hyperplasia (ADH) diagnosed on core needle biopsy (CNB) is variable, current standard treatment consists of surgical excision (SE) for all ADH CNB diagnoses. Our objective was to identify features of ADH on CNB that may stratify carcinoma upgrade risk on SE. METHODS: We retrospectively analyzed cases diagnosed as ADH on CNB. An independent slide review and detailed analysis of radiological and clinical data was performed...
November 20, 2018: Breast Journal
Ahkeel Allen, Allison Cauthen, Paul Dale, Christopher Jean-Louis, Allison Lord, Betsy Smith
Excision of high-risk breast lesions (HRL) continues to be standard of care. Previous studies have shown that HRLs can be upgraded to carcinoma in situ (CIS) or invasive carcinoma (IC) upon excision. A single institution retrospective review was conducted to determine the rate of upgrade of HRLs and ductal carcinoma in situ (DCIS) identified on image-guided biopsy upon excision. Eight hundred and fifty-seven patients who underwent core needle biopsy (CNB) following the detection of suspicious lesions (BI-RADS IV) on mammograms were identified...
November 20, 2018: Breast Journal
Shunsuke Yamada, Hokuto Arase, Toshifumi Morishita, Akihiro Tsuchimoto, Kumiko Torisu, Takehiro Torisu, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13.4 mg/dL. Plasma concentrations of adrenocorticotropic hormone and cortisol and serum luteinizing hormone were under the detection level...
November 19, 2018: CEN Case Reports
Changqing Liu, Kai Zhang, Wenyan Cao, Ge Zhang, Guoqiang Chen, Haiyan Yang, Qian Wang, Haobao Liu, Mo Xian, Haibo Zhang
Background: 2-Phenylethanol (2-PE) is a higher aromatic alcohol that is widely used in the perfumery, cosmetics, and food industries and is also a potentially valuable next-generation biofuel. In our previous study, a new strain Enterobacter sp. CGMCC 5087 was isolated to produce 2-PE from glucose through the phenylpyruvate pathway. Results: In this study, candidate genes for 2-PE biosynthesis were identified from Enterobacter sp. CGMCC 5087 by draft whole-genome sequence, metabolic engineering, and shake flask fermentation...
2018: Biotechnology for Biofuels
Evangelia Liakoni, Hallam Gugelmann, Delia A Dempsey, Timothy J Wiegand, Christopher Havel, Peyton Jacob, Neal L Benowitz
1,4-Butanediol (BDO) - used as solvent, and abused for its euphoric effects - is converted to gamma-hydroxybutyrate (GHB) by the enzyme alcohol dehydrogenase (ADH). This double-blind, placebo-controlled crossover study with six healthy volunteers is the first to date investigating the role of the ADH inhibitor fomepizole (4MP) in moderating this conversion in humans. Participants received on two different days either intravenous placebo or 15 mg/kg 4MP, followed by oral administration of 25 mg/kg BDO. Pretreatment with 4MP resulted in significantly higher BDO maximal plasma concentration (p=0...
November 19, 2018: Clinical Pharmacology and Therapeutics
Reda M Gaafar, Maha M Seyam
In order to investigate the salt tolerance mechanism in Egyptian lentils, five cultivars were grown under different salinity levels. The results indicated that Giza 9 is salt-tolerant, while Giza 4 is a salt-sensitive lentil cultivar, as Giza 9 showed the highest germination percentage and relative water content, the lowest decline in root and shoot length, and the highest proline content. Relative gene expression of ADH , CYS3 , APX , SOD , and GR was significantly upregulated in Giza 9 roots after 24 h of high salt treatment (250 mM), while CAT transcripts level was non-significantly reduced (0...
November 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
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