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L Li, X Geng, R Han, J L Men, B Zhang, S S Li, Z H Zhang
Objective: To put forward the suggestion of the occupational contact limit of tributyl phosphate in the air of the workplace. Methods: Data of production and usage, workers' basic information, occupational history, and physical examinations were collected, and the environmental and individual levels of exposure were monitored using fixed-point and individual sampling. The results of the questionnaire and health examination were statistically analyzed using exact probability method of Fisher in the workers exposed to tributyl phosphate and the control group...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
Daryl J McLeod, Christina B Ching, Yuri V Sebastião, Jason H Greenberg, Susan L Furth, Kirk M McHugh, Brian Becknell
BACKGROUND: Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. METHODS: Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases)...
October 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Weiming Wang, Yan Liu, Shaoxin Sun, Baoyan Liu, Tongsheng Su, Jing Zhou, Zhishun Liu
PURPOSE: The efficacy and safety of electroacupuncture was compared to those of sham electroacupuncture for the treatment of postmenopausal women with stress urinary incontinence (SUI). METHODS: This study was a secondary analysis of a multicenter, randomized controlled trial that recruited 504 women with SUI and randomized 349 postmenopausal women to receive 18 treatment sessions of electroacupuncture or sham electroacupuncture over 6 weeks, with a 24-week follow-up assessment...
October 13, 2018: World Journal of Urology
Reem Alfattouh, Nedaa Aldairi, Nazish Masud, Asma Awadalla
The retrospective study was planned to assess the outcome of extensive investigations done for infants admitted with apparent life-threatening event (ALTE), and comprised chart review of 275 infants admitted to King Abdul-Aziz Medical City (KAMC), Riyadh, Saudi Arabia, between 2012 and 2015. The outcome of each investigation was compared in terms of whether the test was performed or not performed, and, if performed, whether the test report was normal or abnormal. Also, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was assessed for each test...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Balwant Lal, Adil Iqbal, Nasir Farooq Butt, Fawad Ahmad Randhawa, Rabia Rathore, Tariq Waseem
OBJECTIVE: : To determine the efficacy of high-dose allopurinol in reducing left ventricular mass in patients with left ventricular hypertrophy by comparing its efficacy with febuxostat.. METHODS: The randomised controlled interventional study was conducted at Mayo Hospital, Lahore, Pakistan, from April to December 2015, comprising patients with left ventricular hypertrophy on echocardiography. They were randomly divided into two equal groups, with Group A receiving allopurinol and Group B receiving febuxostat...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Efstathios Kotidis, Iliana Stamatiou, Orestis Ioannidis, Manousos George Pramateftakis, Ioannis Kanellos, Konstantinos Tsalis
Lipomas are benign, usually asymptomatic, tumours and pelvic lipomas are extremely rare. We describe the case of a giant pelvic lipoma causing obstructive uropathy to a 66-year-old morbidly obese female treated in the 4th Surgical Department of the Medical School of Aristotle University of Thessaloniki in General Hospital "G. Papanikolaou" in March 2016. The patient presented with a history of nocturia and frequent daytime urination for 1 year. Her medical history included diffuse lipomatosis. Computer tomography revealed a giant pelvic mass which lead to left side hydronephrosis, hydrouterer and a pear-shaped bladder, with the differential diagnosis including pelvic lipoma or liposarcoma...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
October 4, 2018: International Journal of Surgery Case Reports
George Markopoulos, Dimitrios Kitridis, Konstantinos Tsikopoulos, Dimitrios Georgiannos, Ilias Bisbinas
BACKGROUND: Urinary catheters are commonly used in patients undergoing total hip and knee arthroplasty. Bladder training before catheter removal is reported to shorten the time to return to normal bladder function and reduce the incidence of urinary retention. OBJECTIVE: To evaluate the results of bladder training in patients with total hip and knee arthroplasty. DESIGN: Randomized controlled trial. SETTING: Orthopaedic Department of a tertiary Military Hospital...
September 11, 2018: International Journal of Nursing Studies
Yuanyuan Liu, Mengying Wei, Kexin Yue, Mingxin Hu, Shizhe Li, Lihui Men, Zifeng Pi, Zhiqiang Liu, Zhongying Liu
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with no effective method for its treatment so far. The pathogenesis of AD has been reported, but the endogenous metabolic profile and disease-related biomarkers are still not clear. To better understand AD, an AD model induced by injecting β-amyloid 25-35 (Aβ 25-35) solution into bilateral hippocampus was developed on Sprague-Dawley rats. After 8 weeks of modeling, the impairment of spatial learning and memory ability in AD rats were assessed by Morris water maze task...
October 11, 2018: Neuroscience
Timothy R Fennell, Scott L Watson, Suraj Dhungana, Rodney W Snyder
4-Methylimidazole (4-MeI) is a widely used chemical, also identified as a by-product of heating foods. In cancer bioassays, 4-MeI induced lung tumors in mice, but not in rats. To establish if metabolic differences could explain species difference in carcinogenicity, this study investigated metabolism of 4-MeI in rat and mouse lung and liver microsomes and S-9 fractions, and in vivo in rats and mice. No metabolites were detected in rat or mouse lung and liver microsomes, or lung S-9 fractions. Male and female F-344 rats and B6C3F1 mice were administered 50 and 150 mg/kg [14 C] 4-MeI by gavage...
October 11, 2018: Food and Chemical Toxicology
Luke Taylor, Nick Krueger, Olga Malysheva, Jeffrey Atkinson, Robert S Parker
α-Tocopherol (α-TOH) is the primary lipophilic radical trapping antioxidant in human tissues. Oxidative catabolism of α-tocopherol (αTOH) is initiated by ω-hydroxylation of the terminal carbon (C-13) of the isoprenoid sidechain followed by oxidative transformations that sequentially truncate the chain to yield the 2,5,7,8-tetramethyl(3'carboxyethyl)-6-hydroxychroman (α-CEHC). After conjugation to glucuronic acid, 3'-carboxyethyl-6-hydroxychroman glucuronide is excreted in urine. We report here that the same enzyme that accomplishes this task, the cytochrome P450 monooxygenase CYP-4F2, can also ω-hydroxylate the terminal carbon of α-tocopheryl quinone...
October 5, 2018: Bioorganic & Medicinal Chemistry
Shaun R Yockelson, Stephen B Heitner, Sarah Click, Gemechu Geleto, Miriam M Treggiari, Michael P Hutchens
OBJECTIVE: An association between central venous pressure and acute kidney injury (AKI) has been observed following cardiac surgery, but it is unknown whether this reflects intravascular volume status or impaired right ventricular (RV) myocardial performance. This study was performed to test the hypothesis that decreased RV peak longitudinal strain (PLSS), as measured by 2-dimensional speckle-tracking echocardiography, is associated with AKI following cardiac surgery. DESIGN: Retrospective observational cohort study...
September 12, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Andrea Vergara, Mariana J Fernández-Pittol, Ernesto Muñoz-Mahamud, Laura Morata, Jordi Bosch, Jordi Vila, Alex Soriano, Climent Casals-Pascual
BACKGROUND: Periprosthetic joint infection (PJI) remains a major clinical challenge. In this study, we evaluated the diagnostic performance of lipocalin-2 (LCN2), a well-characterized neutrophil protein, in synovial fluid to discriminate PJI and aseptic implant failure. METHODS: Synovial fluid from patients with acute or chronic PJI, aseptic failure, or controls was obtained during surgery. LCN2 was quantified using a modified enzyme immunoassay coupled with chemiluminescence (Architect Urine NGAL; Abbott Laboratories)...
September 22, 2018: Journal of Arthroplasty
Krithika Chennapan, Samuel Mullinax, Eric Anderson, Mark J Landau, Kimberly Nordstrom, Rawle A Seupaul, Michael P Wilson
BACKGROUND: Patients presenting to the emergency department (ED) with psychiatric complaints often require medical screening to evaluate for a medical cause of their symptoms. OBJECTIVE: We sought to evaluate the existing literature on the medical screening of psychiatric patients and establish recommendations for ideal screening practices in Western-style EDs. METHODS: PubMed, PsycINFO, and were searched for clinical studies examining the medical screening of adult psychiatric patients in the ED or inappropriate referrals to psychiatry...
October 10, 2018: Journal of Emergency Medicine
Milad Ghani, Sayed Mehdi Ghoreishi, Mostafa Azamati
The objective of the present study was to develop a simple, sensitive and cost-effective sample pretreatment technique to extract and determine caffeine in different samples of beverage as well as urine. An anodized aluminum bar was electrochemically prepared and employed as nanoporous substrate for in-situ growth of crystals of the zeolitic imidazole framework-67 (ZIF-67). The above-mentioned sorbent, too, was applied as a stir bar sorptive extraction (SBSE) device along with HPLC-UV. Under predetermined experimental condition, the detection limit of the aimed method was 0...
September 27, 2018: Journal of Chromatography. A
R T Pate, D M Paulus Compart, F C Cardoso
Mitigation strategies are vital in minimizing the health and economic risks associated with dairy cattle exposure to aflatoxin (AF). The objective of this study was to determine the effects of a commercially available aluminosilicate clay in a lactation diet on production responses, blood chemistry, and liver inflammatory markers of multiparous lactating Holstein cows during an AF challenge. Sixteen multiparous lactating Holstein cows [body weight (mean ± SD) = 758 ± 76 kg; days in milk = 157 ± 43 d] were assigned to 1 of 4 treatments in a replicated 4 × 4 Latin square design with 21-d periods: no adsorbent and no AF challenge (CON), no adsorbent and an AF challenge (POS), 113 g of aluminosilicate clay top-dressed on the total mixed ration (adsorbent; FloMatrix, PMI Nutritional Additives, Arden Hills, MN) with an AF challenge (F4), or 227 g of adsorbent with an AF challenge (F8)...
October 10, 2018: Journal of Dairy Science
Pahriya Ashrap, Deborah J Watkins, Antonia M Calafat, Xiaoyun Ye, Zaira Rosario, Phil Brown, Carmen M Vélez-Vega, Akram Alshawabkeh, José F Cordero, John D Meeker
BACKGROUND: Understanding important sources and pathways of exposure to common chemicals known or suspected to impact human health is critical to eliminate or reduce the exposure. This is particularly important in areas such as Puerto Rico, where residents have higher exposures to numerous chemicals, as well as higher rates of many adverse health outcomes, compared to the mainland US. OBJECTIVE: The aim of this study was to assess distributions, time trends, and predictors of urinary triclocarban, phenol, and paraben biomarkers measured at multiple times during pregnancy among women living in Northern Puerto Rico...
October 10, 2018: Environment International
Anna R Kahkoska, Scott Isom, Jasmin Divers, Elizabeth J Mayer-Davis, Lawrence Dolan, Amy S Shah, Maryam Afkarian, David J Pettitt, Jean M Lawrence, Santica Marcovina, Sharon H Saydah, Dana Dabelea, David M Maahs, Amy K Mottl
AIMS: To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression. METHODS: Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later)...
October 4, 2018: Journal of Diabetes and its Complications
S Jung, K-M Park, J Hah, K C Hong, S-D Hwang, J Song
Focal segmental glomerulosclerosis (FSGS) is the most common form of post-transplant glomerulonephritis. We describe a case where a biopsy proved that early recurrence of FSGS on postoperative day 1 was the cause of delayed graft function. A 39-year-old man, on hemodialysis for 15 years due to polycystic kidney disease, received a cadaveric renal transplantation. On postoperative day 1, his hourly urine output decreased from 700-800 mL to 50 mL. The graft biopsy showed a mild acute kidney injury confusing nephrotic syndrome...
October 2018: Transplantation Proceedings
Y Kihara, O Konno, T Yokoyama, Y Nakamura, T Ueno, H Iwamoto
INTRODUCTION: The number of young women who wish to become pregnant opting for kidney transplants is increasing, as becoming pregnant under hemodialysis or peritoneal dialysis is associated with many risks. However, there have been reports indicating that these patients are subject to a higher risk of miscarriage compared to women with normal renal function. We examine and report cases of patients that experienced pregnancy after undergoing kidney transplantation at our hospital. SUBJECTS AND METHOD: Of the kidney transplantation cases that were performed at our hospital between 1985 and 2016, there were 7 cases of pregnancy...
October 2018: Transplantation Proceedings
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