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https://www.readbyqxmd.com/read/30554416/daily-oral-cyanocobalamin-supplementation-in-beagles-with-hereditary-cobalamin-malabsorption-imerslund-gr%C3%A3-sbeck-syndrome-maintains-normal-clinical-and-cellular-cobalamin-status
#1
Peter H Kook, Martin Hersberger
BACKGROUND: Efficacy of PO cobalamin (Cbl) supplementation in dogs with hereditary Cbl malabsorption (Imerslund-Gräsbeck syndrome, IGS) is unknown. OBJECTIVES: To evaluate PO Cbl supplementation in Beagles with IGS previously treated parenterally. We hypothesized that 1 mg cyano-Cbl daily PO would maintain clinical and metabolic remission. ANIMALS: Three client-owned Beagles with IGS and 48 healthy control dogs. METHODS: Prospective study...
December 15, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30554411/from-endogenous-compounds-as-biomarkers-to-plasma-derived-nanovesicles-as-liquid-biopsy-has-the-golden-age-of-translational-pk-adme-ddi-science-finally-arrived
#2
REVIEW
David Rodrigues, Andrew Rowland
It is now established that a drug's pharmacokinetics-absorption-distribution-metabolism-excretion-drug-drug interaction (PK-ADME-DDI) profile can be modulated by age, disease, and genotype. In order to facilitate subject phenotyping and clinical DDI assessment, therefore, various endogenous compounds (in plasma and urine) have been pursued as drug-metabolizing enzyme and transporter biomarkers. Compared to biomarkers, however, the topic of circulating extracellular vesicles as "liquid biopsy" has received little attention within the ADME community; most organs secrete nanovesicles (e...
December 16, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30554270/population-pharmacokinetic-modeling-of-sustained-release-lithium-in-the-serum-erythrocytes-and-urine-of-patients-with-bipolar-disorder
#3
C Couffignal, J Bertrand, S Sportiche, Marine Jarroir, S El Balkhi, N Djebrani-Oussedik, J Poupon, X Declèves, F Mentré, F Bellivier
PURPOSE: Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. The present study describes srLi PK in the serum and erythrocytes of bipolar patients. METHODS: To assess srLi PK, we studied prospectively 17 French bipolar patients on a median dose of 1000 mg (600-1600) for at least 2 years...
December 15, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30554219/a-family-with-autosomal-dominant-distal-renal-tubular-acidosis-presents-with-atypical-phenotype-caused-by-a-missence-mutation-r388c-of-the-human-kidney-anion-exchanger
#4
Dongdong Wang, Yang Yu, Renee Wang, Yitong Cai, Yacai Li, Chol Min Choe, Haixia Guan, Xiaoli Wang
Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. A 30-year-old male patient has a history of paroxysmal paralysis for 7 years, presenting with mild hypokalemia, alkalization of urine, normal blood PH value and increased urinary calcium...
December 14, 2018: Nephron
https://www.readbyqxmd.com/read/30554210/is-there-a-relation-between-serum-uric-acid-values-and-prostatic-calculi-presence
#5
Mehmet Balasar, Mehmet Giray Sönmez, Arif Aydın, Yunus Emre Göger, Mehmet Serkan Özkent, Necdet Poyraz
OBJECTIVE: We planned to examine the connection between serum uric acid (UA) values and prostatic calculi (PCal) presence and to evaluate the relation between PCal and other etiological factors. METHODS: Patients between 20 and 60 years of age who were referred to the clinic with any reason and had non-contrast abdominal tomography (NCACT) for PCal were included in the study. While the patients were separated into 2 groups based on their serum UA level as ≥7 mg/dL (Group 1) and < 7 mg/dL (Group 2), NCACT was also divided into 2 groups as PCal presence (PCal+) and lack (PCal-) serum UA, calcium, phosphorus, sodium, prostate-specific antigen levels and urinary analysis results of the patients were evaluated and compared...
December 14, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30554097/simultaneous-detection-of-atp-metabolites-in-human-plasma-and-urine-based-on-palladium-nanoparticle-and-poly-bromocresol-green-composite-sensor
#6
Mamta Raj, Jong-Min Moon, Rajendra N Goyal, Deog-Su Park, Yoon-Bo Shim
A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes...
December 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30553612/prospective-validation-of-an-mrna-based-urine-test-for-surveillance-of-patients-with-bladder-cancer
#7
F Johannes P van Valenberg, Andrew M Hiar, Ellen Wallace, Julia A Bridge, Donna J Mayne, Safedin Beqaj, Wade J Sexton, Yair Lotan, Alon Z Weizer, Godfrey K Jansz, Arnulf Stenzl, John F Danella, Barry Shepard, Kevin J Cline, Michael B Williams, Scott Montgomery, Richard D David, Richard Harris, Eric W Klein, Timothy J Bradford, Fred N Wolk, Karl R Westenfelder, Andrew F Trainer, Timothy A Richardson, Russell B Egerdie, Bernard Goldfarb, Joseph A Zadra, Sijian Ge, Suling Zhao, Iris M Simon, Scott A Campbell, Brian Rhees, Michael P Bates, Russell G Higuchi, J Alfred Witjes
BACKGROUND: A fast, noninvasive test with high sensitivity (SN) and a negative predictive value (NPV), which is able to detect recurrences in bladder cancer (BC) patients, is needed. A newly developed urine assay, Xpert Bladder Cancer Monitor (Xpert), measures five mRNA targets (ABL1, CRH, IGF2, UPK1B, and ANXA10) that are frequently overexpressed in BC. OBJECTIVE: To validate Xpert characteristics in patients previously diagnosed with non-muscle-invasive BC. DESIGN, SETTING, AND PARTICIPANTS: Voided precystoscopy urine samples were prospectively collected at 22 sites...
December 12, 2018: European Urology
https://www.readbyqxmd.com/read/30553469/evaluation-of-commercial-kits-for-purification-of-circulating-free-dna
#8
Russell J Diefenbach, Jenny H Lee, Richard F Kefford, Helen Rizos
Analysis of liquid biopsies and the identification of non-invasive biomarkers for the diagnosis and prognosis of solid tumors has grown exponentially over the last few years. This has led to an increasing number of commercial kits optimised for the purification of circulating free (cf) DNA and RNA/miRNA from biofluids such as plasma, serum and urine. To optimise and standardise current practices we sought to evaluate the performance of spin column-based and magnetic bead-based commercial kits. The following commercial cfDNA purification kits were analysed in this study: QIAamp circulating nucleic acid kit (Qiagen, Germany); Plasma/serum cell-free circulating DNA Purification midi kit (Norgen Biotek, Canada); QIAamp minElute ccfDNA mini kit (Qiagen); Maxwell RSC ccfDNA plasma kit (Promega, USA); MagMAX cell-free DNA isolation kit (Applied Biosystems, USA); and NextPrep-Mag cfDNA isolation kit (Bioo Scientific, USA)...
December 2018: Cancer Genetics
https://www.readbyqxmd.com/read/30553283/discharge-materials-provided-to-patients-with-kidney-stones-in-the-emergency-department-may-be-a-source-of-misinformation
#9
Kevan M Sternberg, Andrew Pham, Theodore Cisu, Marissa L Kildow, Kristina L Penniston
INTRODUCTION: Renal colic is commonly seen in the emergency department (ED), where the focus is on diagnosis and symptom control. Educational materials are sometimes provided upon discharge, however, no standard content has been established. We characterized the educational materials given to patients reporting to EDs in different regions across the U.S. for symptomatic kidney stones, specifically evaluating disease-specific information, symptom management, prevention strategies including dietary recommendations (DRs), and patient follow up plans...
December 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/30553217/differential-exposure-to-organophosphate-flame-retardants-in-mother-child-pairs
#10
Elizabeth A Gibson, Heather M Stapleton, Lehyla Calero, Darrell Holmes, Kimberly Burke, Rodney Martinez, Boris Cortes, Amy Nematollahi, David Evans, Kim A Anderson, Julie B Herbstman
BACKGROUND: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment. OBJECTIVES: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs...
December 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/30553203/urinary-levels-of-bisphenol-a-f-and-s-and-markers-of-oxidative-stress-among-healthy-adult-men-variability-and-association-analysis
#11
Yi-Xin Wang, Chong Liu, Ying Shen, Qi Wang, An Pan, Pan Yang, Ying-Jun Chen, Yan-Ling Deng, Qing Lu, Li-Ming Cheng, Xiao-Ping Miao, Shun-Qing Xu, Wen-Qing Lu, Qiang Zeng
BACKGROUND: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. OBJECTIVE: To evaluate the variability and associations of levels of BPA, BPS, BPF and 3 oxidative stress markers [i...
December 12, 2018: Environment International
https://www.readbyqxmd.com/read/30552966/osteoarthritis-year-in-review-2018-biomarkers-biochemical-markers
#12
REVIEW
Fatemeh Saberi Hosnijeh, Sita M Bierma-Zeinstra, Anne C Bay-Jensen
OBJECTIVE: The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need. DESIGN: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded...
December 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/30552922/the-effect-of-different-post-exercise-beverages-with-food-on-ad-libitum-fluid-recovery-nutrient-provision-and-subsequent-athletic-performance
#13
Danielle McCartney, Christopher Irwin, Gregory R Cox, Ben Desbrow
This study investigated the effect of consuming either water or a carbohydrate (CHO)-electrolyte sports beverage ('Sports Drink') ad libitum with food during a 4 h post-exercise recovery period on fluid restoration, nutrient provision and subsequent endurance cycling performance. On two occasions, 16 endurance-trained cyclists; 8 male [M] (age: 31 ± 9 y; VO2max : 54 ± 6 mL·kg-1 ·min-1 ) and 8 female [F] (age: 33 ± 8 y; VO2max : 50 ± 7 mL·kg-1 ·min-1 ); lost 2.3 ± 0.3% and 1...
December 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/30552306/urinary-neutrophil-gelatinase-associated-lipocalin-kidney-injury-molecule-1-uromodulin-and-cystatin-c-concentrations-in-an-experimental-rat-model-of-ascending-acute-kidney-injury-induced-by-pyelonephritis
#14
B Skowron, A Baranowska, L Dobrek, K Ciesielczyk, J Kaszuba-Zwoinska, G Wiecek, A Malska-Wozniak, M Strus, K Gil
Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 105 CFU/ml), pyelonephritis-induced AKI (group 2, 107 CFU/ml), or AKI and urosepsis (group 3, 109 CFU/ml)...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30551942/facile-synthesis-of-molecularly-imprinted-polymers-for-selective-extraction-of-tyrosine-metabolites-in-human-urine
#15
Xianyu Liang, Fan Liu, Yiqun Wan, Xiaoying Yin, Weiting Liu
In this study a method is developed for quantitative analysis of three potential biomarkers, including 4-hydroxyphenyl acetic acid (PHPAA), 4-hydroxyphenyl lactic acid (PHPLA) and 3,4-hydroxyphenylpropionic acid (PHPA), in human urine. Molecular imprinted polymers (MIPs) as the sample clean up materials were applied to selectively extract these tyrosine metabolites, followed by precise detection using ultra-high performance liquid chromatography coupled with a fluorescence detector (UHPLC-FLD). The MIP was prepared by precipitation polymerization adopting PHPAA as the template molecule, 1-vinylimidazole (1-vinyl) as functional monomer, trimethylolpropane triacrylate (TRIM) as crosslinker, 2-methylpropionitrile (AIBN) as initiator and acetonitrile as a porogen...
December 10, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30551739/pancreatic-carcinoma-underlying-a-complex-presentation-in-late-pregnancy-a-case-report
#16
Ai-Wu Shi, Xiao-Feng Shen, Hong-Juan Ding, Yao-Qiu Liu, Li Meng, Bill Kalionis
BACKGROUND: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Pancreatic adenocarcinoma is one of the most common malignancies associated with thromboembolic events. A clinical study showed that thromboembolic events were detected in 36% of patients diagnosed as having pancreatic cancer...
December 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30551434/pterostilbene-a-bioactive-component-of-blueberries-alleviates-renal-fibrosis-in-a-severe-mouse-model-of-hyperuricemic-nephropathy
#17
Jing Pan, Min Shi, Lingzhi Li, Jing Liu, Fan Guo, Yanhuan Feng, Liang Ma, Ping Fu
Accumulating evidences indicated that hyperuricemia was an independent risk factor for kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases. In the study, pterostilbene (PTE) as a bioactive component of blueberries was confirmed to possess lowering serum uric acid and renal protective functions by the decrease of serum creatinine, BUN, urine albumin, and urine albumin-to-creatinine ratio (uACR) in a mouse model of hyperuricemic nephropathy (HN)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551387/zengye-decoction-induces-alterations-to-metabolically-active-gut-microbiota-in-aged-constipated-rats
#18
Deliang Liu, Lei Lin, Yixuan Lin, Yuping Zhong, Shaobao Zhang, Wen Liu, Baorong Zou, Qiongfeng Liao, Zhiyong Xie
Zengye decoction (ZYD), a traditional Chinese medicinal formula, has been used in the treatment of various chronic diseases, such as constipation and skin dryness syndrome. Clinically, the specific mechanisms and targets of ZYD for treating disease remain unclear. The present study was undertaken to investigate the effects of ZYD on the gut microbiota and host metabolites in aged constipated rats and the relationship between the intestinal microbiota and the host. Rats were divided randomly into three groups, the control group (n = 10), recovery group (n = 10) and ZYD group (n = 10)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551216/uromodulin-in-a-pathway-between-decreased-renal-urate-excretion-and-albuminuria
#19
Alena Krajcoviechova, Francois-Christophe Marois-Blanchet, Stephan Troyanov, Francois Harvey, Pierre Dumas, Johanne Tremblay, Renata Cifkova, Philip Awadalla, Francois Madore, Pavel Hamet
Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e., SLC2A9, SLC22A12, ABCG2) on the association between fractional excretion of uric acid (FEUA) and urinary albumin/creatinine ratio (uACR). Second, we examined uromodulin and sodium excretion as mediators of the association between FEUA and uACR. Methods: We performed cross-sectional analysis of 737 French Canadians from the CARTaGENE cohort, a random sample of the Quebec population aged 40-69 years (a total of 20,004 individuals)...
December 14, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30551159/elagolix-for-endometriosis-all-that-glitters-is-not-gold
#20
Paolo Vercellini, Paola Viganò, Giussy Barbara, Laura Buggio, Edgardo Somigliana
Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with elagolix is dose-dependent, pain relief may be achieved by modulating the level of hypo-oestrogenism while limiting side effects. Elagolix may thus be considered a novelty in terms of its endocrine and pharmacological properties but not for its impact on the pathogenic mechanisms of endometriosis, as the target of this new drug is, yet again, alteration of the hormonal milieu...
December 14, 2018: Human Reproduction
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