Anthony J Swerdlow, Rosie Cooke, Andrew Bates, David Cunningham, Stephen J Falk, Dianne Gilson, Barry W Hancock, Sarah J Harris, Alan Horwich, Peter J Hoskin, David C Linch, Andrew Lister, Helen H Lucraft, John Radford, Andrea M Stevens, Isabel Syndikus, Michael V Williams
BACKGROUND: Modern treatment of Hodgkin's lymphoma (HL) has transformed its prognosis but causes late effects, including premature menopause. Cohort studies of premature menopause risks after treatment have been relatively small, and knowledge about these risks is limited. METHODS: Nonsurgical menopause risk was analyzed in 2127 women treated for HL in England and Wales at ages younger than 36 years from 1960 through 2004 and followed to 2003 through 2012. Risks were estimated using Cox regression, modified Poisson regression, and competing risks...
September 2014: Journal of the National Cancer Institute