keyword
https://read.qxmd.com/read/36657604/orobol-3-hydroxy-genistein-suppresses-the-development-and-regrowth-of-cutaneous-scc
#1
JOURNAL ARTICLE
Eunmiri Roh, Jong-Eun Kim, Tianshun Zhang, Seung Ho Shin, Byung-Gee Kim, Jian Li, Xinli Ma, Ki Won Lee, Zigang Dong
Chronic solar ultraviolet exposure is a major risk factor for cutaneous squamous cell carcinoma (cSCC), which is the second most common type of skin cancer. Our previous data showed that total protein and phosphorylation levels of T-LAK cell-originated protein kinase (TOPK) were enhanced in solar-simulated light (SSL)-induced skin carcinogenesis and overexpressed in actinic keratosis (AK) and cSCC human skin tissues compared to those in matched normal skin. Thus, targeting TOPK activity could be a helpful approach for treating cSCC...
January 16, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/36596118/integration-of-metabolomics-and-transcriptomics-analyses-investigates-the-accumulation-of-secondary-metabolites-in-maturing-seed-plumule-of-sacred-lotus-nelumbo-nucifera
#2
JOURNAL ARTICLE
Dongli He, Xiaolan Rao, Jiao Deng, Rebecca N Damaris, Pingfang Yang
Lotus seed plumule (LP) is rich in a variety of antioxidant and anti-inflammatory secondary metabolites, making it a traditional food and medicine widely used in China. Physiological and histological evidences indicated that LP mainly accumulated metabolites in 15-24 days after pollination (DAP) during their development. To systematically investigate the dynamic accumulation of major secondary metabolites, the UPLC-HRMS-based widely targeted metabolomics analyses were performed on maturing LP at 15, 18, 21, and 24 DAP...
January 2023: Food Research International
https://read.qxmd.com/read/36575696/combined-orobol-bentonite-composite-formulation-for-effective-topical-skin-targeted-therapy-in-mouse-model
#3
JOURNAL ARTICLE
Duy-Thuc Nguyen, Min-Hwan Kim, Na-Young Yu, Min-Jun Baek, Kyung-Sun Kang, Ki Won Lee, Dae-Duk Kim
PURPOSE: Orobol is an isoflavone that has a potent skin protection effect. The objective of this study was to prepare a novel bentonite-based composite formulation of orobol to enhance topical skin delivery. METHODS: The composition was optimized based on the orobol content in the composite and the in vitro release studies, followed by the in vitro and in vivo hairless mouse skin deposition studies. Physicochemical characterizations of the composite formulation were performed by powder X-ray refractometry (XRD) and scanning electron microscopy (SEM)...
2022: International Journal of Nanomedicine
https://read.qxmd.com/read/35889386/vietnamese-dalbergia-tonkinensis-a-promising-source-of-mono-and-bifunctional-vasodilators
#4
JOURNAL ARTICLE
Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Yoshiyasu Fukuyama, Amer Ahmed, Simona Saponara, Alfonso Trezza, Beatrice Gianibbi, Ginevra Vigni, Ottavia Spiga, Fabio Fusi
Hypertension is a risk factor for cardiovascular diseases, which are the main cause of morbidity and mortality in the world. In the search for new molecules capable of targeting KCa 1.1 and CaV 1.2 channels, the expression of which is altered in hypertension, the in vitro vascular effects of a series of flavonoids extracted from the heartwoods, roots, and leaves of Dalbergia tonkinensis Prain, widely used in traditional medicine, were assessed. Rat aorta rings, tail artery myocytes, and docking and molecular dynamics simulations were used to analyse their effect on these channels...
July 14, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35381342/genus-suaeda-advances-in-phytology-chemistry-pharmacology-and-clinical-application-1895-2021
#5
REVIEW
Xueyu Wang, Xinting Shao, Wenjun Zhang, Tong Sun, Yuling Ding, Zhe Lin, Yong Li
More than 100 species of annual herb genus Suaeda widely distribute (Asia, North America, northern Africa and Europe), are rich in resources (about hundreds of millions of tons/Y) and have a long historical application. Most of them are mainly used for traditional food, feed and medicine. Recently, they have been employed to repair saline-alkali land and beautify the environment. So far, only 27 species have been reported on the bioactivity diversity, broad spectrum and effectiveness in clinical practice. Therefore, the in-depth and extensive research of Suaeda has become a research hotspot around the world...
May 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/35355022/orobol-from-enzyme-biotransformation-attenuates-dermatophagoides-farinae-induced-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#6
JOURNAL ARTICLE
Chang Hyung Lee, Hee Yang, Jung Han Yoon Park, Jong-Eun Kim, Ki Won Lee
Orobol, a metabolite of genistein, is rare in natural soybean. Several studies have revealed the immune-controlling effects of orobol on inflammatory diseases. Furthermore, a few studies have demonstrated that orobol decreases pro-inflammatory compounds resulting in the alleviation of allergic reactions. However, the relationship between orobol and atopic dermatitis (AD) in animal models has not been revealed. Therefore, we sought to investigate the effects of orobol on AD-like symptoms. AD-like symptoms and skin lesions were induced by repeated topical application of Dermatophagoides farinae extract (DFE) on the skin of NC/Nga mice...
March 31, 2022: Food & Function
https://read.qxmd.com/read/34881488/antioxidant-capacity-and-fragmentation-features-of-c-glycoside-isoflavones-by-high-resolution-electrospray-ionization-tandem-mass-spectrometry-using-collision-induced-and-high-energy-collisional-dissociation-techniques
#7
JOURNAL ARTICLE
Patricia Homobono Brito de Moura, Andrea Porzel, Rafaela Machado Nunes, Leopoldo Clemente Baratto, Ludger A Wessjohann, Roberto Carlos Campos Martins, Ivana Correa Ramos Leal
The rapid annotation and identification by mass spectrometry techniques of flavonoids remains a challenge, due to their structural diversity and the limited availability of reference standards. This study applies a workflow to characterize two isoflavonoids, the orobol-C-glycosides analogs, using high-energy collisional dissociation (HCD)- and collision-induced dissociation (CID)-type fragmentation patterns, and also to evaluate the antioxidant effects of these compounds by ferric reducing antioxidant power (FRAP), 2,2'-azino-bis(3-ethylbenzothiazolin acid) 6-sulfonic acid (ABTS), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods...
November 9, 2021: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/34500290/structural-requirements-of-flavonoids-for-the-selective-inhibition-of-%C3%AE-amylase-versus-%C3%AE-glucosidase
#8
JOURNAL ARTICLE
Jongbin Lim, Mario G Ferruzzi, Bruce R Hamaker
In the present study, 14 structurally unique flavonoids were screened to systematically investigate structural requirements for selectively inhibiting human α-amylase versus α-glucosidase to obtain a slow but complete starch digestion for health benefit. The selective inhibition property of three flavonoids chosen against the two classes of starch digestive enzymes was confirmed through various analytical techniques - in vitro inhibition assay, fluorescence quenching, kinetic study, and molecular modeling...
August 30, 2021: Food Chemistry
https://read.qxmd.com/read/32899309/lipid-nanoparticles-for-enhancing-the-physicochemical-stability-and-topical-skin-delivery-of-orobol
#9
JOURNAL ARTICLE
Min-Hwan Kim, Yae-Eun Jeon, Soobeen Kang, Jae-Young Lee, Ki Won Lee, Ki-Taek Kim, Dae-Duk Kim
Orobol is one of the major soy isoflavones, and has been reported to have various pharmacological activities, including an anti-skin-aging effect. However, since it has low solubility in water and physicochemical instability, the formulation of orobol for delivery into the dermal layer of the skin could be challenging. The objective of this study was to prepare lipid nanoparticles formulations of orobol to enhance its stability as well as its deposition into the skin. Formulations of orobol-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were characterized in terms of their mean particle size, entrapment efficiency, and morphology...
September 3, 2020: Pharmaceutics
https://read.qxmd.com/read/32627753/orobol-a-derivative-of-genistein-inhibits-heat-killed-propionibacterium-acnes-induced-inflammation-in-hacat-keratinocytes
#10
JOURNAL ARTICLE
Yunsil Oh, Hwan Ju Hwang, Hee Yang, Jong Hun Kim, Jung Han Yoon Park, Jong-Eun Kim, Ki Won Lee
Acne is a chronic skin disease that typically occurs in the teens and twenties, and its symptoms vary according to age, sex, diet, and lifestyle. Acne is characterized by hyperproliferation of keratinocytes in the epidermis, sebum overproduction, growth of Propionibacterium acnes , and P. acnes induced skin inflammation. Interleukin (IL)-1α and IL-6 are predominant in the inflammatory lesions of acne vulgaris. These cytokines induce an inflammatory reaction in the skin in the presence of pathogens or stresses...
June 22, 2020: Journal of Microbiology and Biotechnology
https://read.qxmd.com/read/32285655/correction-to-orobol-an-isoflavone-exhibiting-regulatory-multifunctionality-against-four-pathological-features-of-alzheimer-s-disease
#11
Geewoo Nam, Yonghwan Ji, Hyuck Jin Lee, Juhye Kang, Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim
No abstract text is available yet for this article.
April 14, 2020: ACS Chemical Neuroscience
https://read.qxmd.com/read/31665823/translating-in-vitro-acrolein-trapping-capacities-of-tea-polyphenol-and-soy-genistein-to-in-vivo-situation-is-mediated-by-the-bioavailability-and-biotransformation-of-individual-polyphenols
#12
JOURNAL ARTICLE
Qiju Huang, Yingdong Zhu, Lishuang Lv, Shengmin Sang
SCOPE: Acrolein is a highly toxic unsaturated aldehyde. Humans are both endogenously and exogenously exposed to acrolein. Long-term exposure to acrolein leads to various chronic diseases. Dietary polyphenols have been reported to be able to attenuate acrolein-induced toxicity in vitro via formation of acrolein-polyphenol conjugates. However, whether in vitro acrolein-trapping abilities of polyphenols can be maintained under in vivo environments is still unknown. METHODS AND RESULTS: Two most commonly consumed dietary polyphenols, (-)-epigallocatechin-3-gallate (EGCG) from tea and genistein from soy, were used to evaluate for their anti-acrolein behaviors both in vitro and in mice...
October 30, 2019: Molecular Nutrition & Food Research
https://read.qxmd.com/read/31222064/orobol-an-enzyme-convertible-product-of-genistein-exerts-anti-obesity-effects-by-targeting-casein-kinase-1-epsilon
#13
JOURNAL ARTICLE
Hee Yang, Sang-Hyuk Lee, Hae Ji, Jong-Eun Kim, Ra Yoo, Jong Hun Kim, Sujin Suk, Chul Sung Huh, Jung Han Yoon Park, Yong-Seok Heo, Han-Seoung Shin, Byung-Gee Kim, Ki Won Lee
Soy isoflavones, particularly genistein, have been shown to exhibit anti-obesity effects. When compared with the isoflavones genistin, daidzin, coumestrol, genistein, daidzein, 6-o-dihydroxyisoflavone, equol, 3'-o-dihydroxyisoflavone, and 8-o-dihydroxyisoflavone, a remarkably higher inhibitory effect on lipid accumulation was observed for orobol treatment during adipogenesis in 3T3-L1 cells. To identify the cellular target of orobol, its pharmacological effect on 395 human kinases was analyzed. Of the 395 kinases, orobol showed the lowest half maximal inhibitory concentration (IC50 ) for Casein Kinase 1 epsilon (CK1ε), and bound to this target in an ATP-competitive manner...
June 20, 2019: Scientific Reports
https://read.qxmd.com/read/31199606/orobol-an-isoflavone-with-regulatory-multifunctionality-against-four-pathological-factors-of-alzheimer-s-disease
#14
JOURNAL ARTICLE
Geewoo Nam, Yonghwan Ji, Hyuck Jin Lee, Juhye Kang, Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim
We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-β, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of acetylcholinesterase. Such framework with multifunctionality could be useful for developing chemical reagents to advance our understanding of multi-faceted pathologies of neurodegenerative disorders, including Alzheimer's disease.
June 14, 2019: ACS Chemical Neuroscience
https://read.qxmd.com/read/30365230/flavonoids-as-putative-modulators-of-%C3%AE-4-%C3%AE-5-and-%C3%AE-6-desaturases-studies-in-cultured-hepatocytes-myocytes-and-adipocytes
#15
JOURNAL ARTICLE
Gianna Kühn, Kathrin Pallauf, Carsten Schulz, Gerald Rimbach
This study was conducted to screen flavonoids for affecting expression of desaturases involved in omega-3 fatty acid synthesis and ceramide (CER) metabolism. To this end, cultured HepG2 hepatocytes, C2C12 myocytes, and 3T3-L1 adipocytes were treated with nontoxic concentrations of 12 selected flavonoids and expression of Δ4-, Δ5-, and Δ6-desaturases (DEGS1, FADS1, and FADS2, respectively) was determined. The flavonoids tested were more cytotoxic to HepG2 and 3T3-L1 than to C2C12 cells. In HepG2 cells, FADS1 was induced by quercetin and FADS2 expression was increased by daidzein, genistein, and pratensein treatment...
September 2018: BioFactors
https://read.qxmd.com/read/30011063/circular-permutation-of-a-bacterial-tyrosinase-enables-efficient-polyphenol-specific-oxidation-and-quantitative-preparation-of-orobol
#16
JOURNAL ARTICLE
Pyung-Gang Lee, Sang-Hyuk Lee, Eun Young Hong, Stefan Lutz, Byung-Gee Kim
Tyrosinase is a type-3 copper oxygenase that catalyzes a phenol moiety into ortho-diphenol, and subsequently to ortho-quinone. Diverse tyrosinases have been observed across the kingdom including Animalia, Bacteria, Plantae, and Fungi. Among the tyrosinases, bacterial and mushroom tyrosinases have been extensively exploited to prepare melanin, ortho-hydroxy-polyphenols or novel plant secondary metabolites during the past decade. And their use as a biocatalyst to prepare various functional bio-compounds have drawn great attention worldwide...
July 16, 2018: Biotechnology and Bioengineering
https://read.qxmd.com/read/29737209/inhibitory-effects-of-amentoflavone-and-orobol-on-daclatasvir-induced-resistance-associated-variants-of-hepatitis-c-virus
#17
JOURNAL ARTICLE
Wei-Ping Lee, Keng-Li Lan, Shi-Xian Liao, Yi-Hsiang Huang, Ming-Chih Hou, Keng-Hsin Lan
Hepatitis C virus (HCV) is recognized as a major causative agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite rapid progress in the development of direct-acting antivirals (DAA) against HCV infection in recent years, cost-effective antiviral drugs with more affordable prices still need to be developed. In this study, we screened a library of natural compounds to identify natural HCV inhibitors. The library of the pure compounds extracted from Chinese herbs deposited in the chemical bank of National Research Institute of Chinese Medicine (NRICM), Taiwan was screened in the cell culture-derived HCV (HCVcc) system...
2018: American Journal of Chinese Medicine
https://read.qxmd.com/read/29381070/probing-the-antiallergic-and-anti-inflammatory-activity-of-biflavonoids-and-dihydroflavonols-from-dietes-bicolor
#18
JOURNAL ARTICLE
Iriny M Ayoub, Michal Korinek, Tsong-Long Hwang, Bing-Hung Chen, Fang-Rong Chang, Mohamed El-Shazly, Abdel Nasser B Singab
Dietes bicolor (Iridaceae) is an ornamental plant used by African local healers to treat diarrhea and dysentery. A new dihydroflavonol, (2R,3R)-3,5,7-trihydroxy-8-methoxyflavanone (1); two known dihydroflavonols, trans-3-hydroxy-5-methoxy-6,7-methylenedioxyflavanone (2) and trans-3-hydroxy-5,7-dimethoxyflavanone (3); the known isoflavone orobol 7,3'-di-O-methyl ether (4); the known biflavones lanaroflavone (5), robustaflavone (6), and amentoflavone (7); and β-sitosterol (8) were isolated from the CH2 Cl2 fraction of D...
February 23, 2018: Journal of Natural Products
https://read.qxmd.com/read/28958517/antioxidant-phenolic-compounds-isolated-from-wild-pyrus-ussuriensis-maxim-fruit-peels-and-leaves
#19
JOURNAL ARTICLE
Daren Qiu, Jie Guo, Huimei Yu, Jiao Yan, Shengxiang Yang, Xiang Li, Yamei Zhang, Jinzhu Sun, Jie Cong, Shuliang He, Dongsheng Wei, Jian-Chun Qin
Thirteen phenolic compounds were isolated from pear (Pyrus ussuriensis Maxim.) peels and leaves extracts by using various column chromatography techniques with a guided DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging assay, the result of antioxidant activity of phenolic compounds is then verified by measurement of ROS (reactive oxygen species). The isolated compounds were identified as rutin (1), (-)-catechin (2), orobol (3), daidzein (4), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (5), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl-9″-O-acetyl)-glyceryl] ether (6), 5,7,3',5'-tetrahydroxyflavanone (7), artselaeroside A (8), trilobatin (9), 3-(2,4,6-trihydroxyphenyl)-1-(4-hydroxyphenyl)-propan-1-one (10), quercetin-3-O-(3″-O-galloyl)-α-l-rhamnopyranoside (11), apigenin (12) and quercetin (13) on the basis of nuclear magnetic resonance spectroscopy along with comparison with literature data...
February 15, 2018: Food Chemistry
https://read.qxmd.com/read/28357634/bioactive-flavonoids-from-flos-sophorae
#20
JOURNAL ARTICLE
Wenzhong Shi, Lili Liu, Jian Li, Lu Qu, Xu Pang, Haiyang Yu, Yi Zhang, Tao Wang
Three new flavonoid glycosides-soyaflavonosides A (1), B (2), and C (3)-together with 23 known ones were obtained from the 70% EtOH extract of Flos Sophorae (Sophora japonica, Leguminosae). Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14, 18, 20, 22, and 26 were isolated from the Sophora genus for the first time; 12, 19, 24, and 25 were obtained from the species firstly. Moreover, NMR data for compounds 18 and 26 are reported for the first time here. Meanwhile, compounds 4, 8-13, 15, 16, 19, 21, and 22 presented obvious inhibitory effects on TG accumulation in HepG2 cells...
July 2017: Journal of Natural Medicines
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