Gian Pal, Graziella Mangone, Emily J Hill, Bichun Ouyang, Yuanqing Liu, Vanessa Lythe, Debra Ehrlich, Rachel Saunders-Pullman, Vicki Shanker, Susan Bressman, Roy N Alcalay, Priscilla Garcia, Karen S Marder, Jan Aasly, M Maral Mouradian, Samantha Link, Marc Rosenbaum, Sharlet Anderson, Bryan Bernard, Robert Wilson, Glenn Stebbins, William C Nichols, Marie-Laure Welter, Sepehr Sani, Mitra Afshari, Leo Verhagen, Rob M A de Bie, Tom Foltynie, Deborah Hall, Jean-Christophe Corvol, Christopher G Goetz
OBJECTIVE: This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS: Clinical and genetic data from 12 datasets were examined. Global cognition was assessed using the Mattis Dementia Rating Scale (MDRS). Subjects were examined for mutations in GBA and categorized as GBA carriers with or without DBS (GBA+DBS+, GBA+DBS-), and noncarriers with or without DBS (GBA-DBS+, GBA-DBS-)...
March 2022: Annals of Neurology