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"Immunoglobulin A nephropathy"

Bin Zhu, Dong-Rong Yu, Ji-Cheng Lv, Yi Lin, Qiang Li, Jia-Zhen Yin, Yuan-Yuan Du, Xuan-Li Tang, Li-Chan Mao, Qiu-Fen Li, Yue Sun, Ling Liu, Xian-Fa Li, Dan Fei, Xin-Yi Wei, Cai-Feng Zhu, Xiao-Xia Cheng, Hong-Yu Chen, Yong-Jun Wang
BACKGROUND: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. METHODS: In a cohort of 1,965 cases with biopsy-proven IgAN, we examined the associations of SUA concentration with the primary outcome of a composite of all-cause mortality or kidney failure (defined as a reduction of estimated glomerular filtration rate [eGFR] by 40% from baseline, requirements for dialysis and transplantation), or the outcome of kidney failure alone, assessed using Cox and logistic regression models, respectively, with adjustment for confounders...
August 15, 2018: American Journal of Nephrology
Li Tan, Yi Tang, Wei Peng, Bechu Shelley Mathew, Wei Qin
BACKGROUND/AIMS: Treatment of advanced Immunoglobulin A nephropathy (IgAN) patients with estimated glomerular filtration rate (eGFR) below 45 mL/min per 1.73 m2 remains inconsistent. The aim of this study is to compare the effects of corticosteroid and immunosuppressant therapies among these patients. METHODS: A total of 201 adult patients with advanced IgAN (eGFR < 45 mL/min/1.73 m2 and proteinuria > 1 g/24h at biopsy) grouped into supportive care (SC), steroids alone (CS), and steroids plus immunosuppressant (IT) groups, were investigated between 30th December 2002 and 30th June 2016...
August 10, 2018: Kidney & Blood Pressure Research
Guangyu Zhou, Guangda Xin, Wenlong Zhang, Xiaofei Zhang
AIM: The study aimed to explore biomarkers for membranous nephropathy (MN) diagnosis, and to provide novel insights into pathogenesis of this disease. METHODS: The microarray dataset GSE73953 was used, which contained 15 immunoglobulin A nephropathy (IgAN) samples, 8 MN samples and 2 healthy controls. Pretreatments were performed for the raw data then the differentially expressed genes (DEGs) were screened out by limma package. Function and pathways of these genes were revealed through enrichment analysis...
August 7, 2018: Nephrology
Hassan Mehmood, Najwa Pervin, Muhammad Israr Ul Haq, Khushbakht Ramsha Kamal, Asghar Marwat, Muzammil Khan
Raoultella planticola is a gram-negative, aerobic, nonmotile mostly found in environments with high prevalence in soil and water. This organism is a very rare human pathogen as only 29 cases of Raoultella planticola -related infections have been reported until 2017, with only 7 cases in the United States. Only 3 cases of urinary tract infection secondary to R planticola have been reported, 1 in a pediatric patient and 2 in adults. In this article, we present a case of R planticola urinary tract infection in a 65-year-old male with immunoglobulin A nephropathy...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Yingbo Guo, Wenfeng Gao, Danyang Wang, Weijing Liu, Zhongjie Liu
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most frequent primary glomerulopathy worldwide. The study aimed to provide potential molecular biomarkers for IgAN management. METHODS: The public gene expression profiling GSE58539 was utilized, which contained 17 monocytes samples (8 monocytes samples isolated from IgAN patients and 9 monocytes samples isolated from healthy blood donors). Firstly, differentially expressed genes (DEGs) between the two kinds of samples were identified by limma package...
July 20, 2018: BMC Nephrology
Ran Luo, Shui-Ming Guo, Yue-Qiang Li, Yi Yang, Meng-Lan Li, Min Han, Xiao-Feng He, Shu-Wang Ge, Gang Xu
Background: A recognized noninvasive biomarker to improve risk stratification of immunoglobulin A nephropathy (IgAN) patients is scarce. Fractalkine has been shown to play a key role in glomerular disease as chemoattractant, adhesion and even fibrosis factor. The current study assessed the possibility of plasma fractalkine as a novel biomarker in IgAN patients. Methods: Plasma fractalkine was measured in 229 patients with renal biopsy consistent IgAN from 2012 to 2014, and clinical, pathological and prognostic relationships were analyzed...
July 12, 2018: Nephrology, Dialysis, Transplantation
Toshiyuki Watanabe, Toshiyuki Hattori, Yayoi Ogawa, Satoshi Jodo
No abstract text is available yet for this article.
July 2018: Clinical and Experimental Rheumatology
Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Yasuhiro Okabe, Masafumi Nakamura, Takanari Kitazono, Kazuhiko Tsuruya
AIM: Recent studies have suggested that patients with post-transplant immunoglobulin A nephropathy have poor graft survival. There is limited research on the therapeutic effectiveness for post-transplant immunoglobulin A nephropathy, especially steroid pulse therapy. The present study evaluated the efficacy of steroid pulse therapy on post-transplant immunoglobulin A nephropathy. METHODS: We retrospectively analyzed patients diagnosed with de novo or recurrent immunoglobulin A nephropathy at Kyushu University Hospital between January 2013 and August 2015...
July 2018: Nephrology
Y Liu, G-M-Y Zhang, X Peng, Y Wen, W Ye, K Zheng, X Li, H Sun, L Chen
AIM: To evaluate renal fibrosis in immunoglobulin A nephropathy (IgAN) using diffusion kurtosis imaging (DKI). MATERIALS AND METHODS: Twenty patients with biopsy-proven IgAN were enrolled. DKI was performed on a clinical 3 T magnetic resonance imaging (MRI) system, and region-of-interest measurements were conducted to determine mean kurtosis (K), mean diffusivity (D), and apparent diffusion coefficient (ADC) of the kidney cortex. Renal biopsy specimens were scored based on the severity of renal fibrosis...
June 18, 2018: Clinical Radiology
Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan, Yong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. However, the relationship between IF intensities of immune proteins and the corresponding serum levels remained unclear, and seldom studies combine histopathological examination results and blood tests together for a predictive purpose...
June 20, 2018: BMC Immunology
Francesco Paolo Schena, Grazia Serino, Fabio Sallustio, Mario Falchi, Sharon N Cox
Immunoglobulin A nephropathy (IgAN) is the most common worldwide primary glomerulonephritis with a strong autoimmune component. The disease shows variability in both clinical phenotypes and endpoints and can be potentially subdivided into more homogeneous subtypes through the identification of specific molecular biomarkers. This review focuses on the role of omics in driving the identification of potential molecular subtypes of the disease through the integration of multilevel data from genomics, transcriptomics, epigenomics, proteomics and metabolomics...
June 13, 2018: Nephrology, Dialysis, Transplantation
Laurie Jansky, Pallavi Mukkamala, Deborah Jebakumar, Arundhati Rao, Tove M Goldson, Samuel N Forjuoh
Dabigatran, a new oral anticoagulant, is a direct thrombin inhibitor used as an alternative to warfarin to reduce the risk of stroke and systemic embolism with nonvalvular atrial fibrillation. We report a case of a man who resumed dabigatran after 6 weeks of prior therapy and began experiencing hematuria with worsening kidney function. Renal biopsy with immunofluorescence and electron microscopy showed mesangial deposits consistent with immunoglobulin A nephropathy. With discontinuation of dabigatran and addition of methylprednisolone, the gross hematuria cleared and urine output improved...
July 2018: Proceedings of the Baylor University Medical Center
Keren Cohen-Hagai, Sydney Benchetrit, Osnat Klein, Yona Kitay-Cohen, Ze'ev Korzets
No abstract text is available yet for this article.
March 2018: Archives of Rheumatology
Yamei Wang, Yuhong Tao
Immunoglobulin A nephropathy (IgAN) is the most frequent pathological diagnosis of tuberculosis (TB)-associated glomerulonephritis. Diagnosing TB-associated IgAN (TB-IgAN) is difficult because of its non-specific and insidious symptoms. An inaccurate diagnosis of TB-IgAN could result in the spread of TB and reduced renal function. Haematuria and proteinuria in conjunction with TB should be assessed because of the potential for diagnosis of IgAN. Renal biopsy is important in securing an accurate diagnosis prior to initiating treatment...
July 2018: Journal of International Medical Research
Richard A Lafayette, Ellie Kelepouris
BACKGROUND: Immunoglobulin A (IgA) nephropathy is the most common form of primary glomerulonephritis and has clinical associations with a wide range of inflammatory and infectious diseases. There is a substantial variation in clinical course and outcomes, with many patients not diagnosed until they present with sequelae, which may include gross hematuria, hypertension, renal insufficiency, and/or significant proteinuria. Treatment options are currently limited and directed mainly toward control of these sequelae and have limited ability to reduce the incidence of end-stage renal disease or treat the primary IgA defect...
2018: American Journal of Nephrology
Lu Yang, Yan Wang, Aobulikasimu Nuerbiye, Ping Cheng, Jin-Hui Wang, Rena Kasimu, Hong Li
Periostracum cicadae, the cast-off shell of the cicada Cryptotympana pustulata Fabricius, is used in traditional Chinese medicine for its diaphoretic, anticonvulsive, sedative, antipyretic, and antiallergic effects. However, the exact pathogenesis of immunoglobulin A nephropathy (IgAN) remains unclear, thereby hindering investigations to identify novel therapeutic agents. A rat IgAN model was established by administration of bovine serum albumin, lipopolysaccharide, and carbon tetrachloride, which simultaneously established blood stasis and a heat syndrome model...
May 29, 2018: International Journal of Molecular Sciences
Yasuhiro Kawai, Kosuke Masutani, Kumiko Torisu, Ritsuko Katafuchi, Shigeru Tanaka, Akihiro Tsuchimoto, Koji Mitsuiki, Kazuhiko Tsuruya, Takanari Kitazono
Serum albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum albumin level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum albumin level: Low, Middle, and High group (≤3...
2018: PloS One
Mariana Gaya da Costa, Felix Poppelaars, Stefan P Berger, Mohamed R Daha, Marc A Seelen
The complement system is composed of a network of at least 40 proteins, which significantly contributes to health and disease. The lectin pathway (LP) is one of three pathways that can activate the complement system. Next to protection of the host against pathogens, the LP has been shown to play a crucial role in multiple renal diseases as well as during renal replacement therapy. Therefore, several complement-targeted drugs are currently being explored in clinical trials. Among these complement inhibitors, specific LP inhibitors are also being tested in renal abnormalities such as in immunoglobulin A nephropathy and lupus nephritis...
April 26, 2018: Nephrology, Dialysis, Transplantation
Ying Zhang, Lili Sun, Suhan Zhou, Qihe Xu, Qiannan Xu, Dongyu Liu, Lu Liu, Ruimin Hu, Songxia Quan, Guolan Xing
BACKGROUND/AIMS: Arterial fibrotic intimal thickening and arteriolar hyaline are considered common pathological features in immunoglobulin A nephropathy (IgAN), whereas little is known about the acute pathological manifestations of endothelial cell injury. The aim of this study was to investigate characteristics of intrarenal arterial lesions and to estimate their prognostic values in patients with IgAN. The primary renal endpoint was a 50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD)...
2018: Kidney & Blood Pressure Research
Shankar Prasad Nagaraju, Dharshan Rangaswamy, Aswani Srinivas Mareddy, Srikanth Prasad, Sindhu Kaza, Srinivas Shenoy, Karan Saraf, Ravindra Prabhu Attur, Rajeevalochana Parthasarathy, Srinivas Kosuru, Uday Venkat Mateti, Vasudeva Guddattu, Sindhura Lakshmi Koulmane Laxminarayana
The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
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