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"Immunoglobulin A nephropathy"

Yuki Muranishi, Nobuyuki Fukuzawa, Yoshiki Wada, Takashige Abe, Nobuo Shinohara, Hiroshi Harada
We report a patient who developed urinary retention due to the presence of necrotic tissues in the bladder 5 months after kidney transplantation. The patient was a 47-year-old female who had been diagnosed with immunoglobulin A nephropathy. She requested to receive a living-donor kidney transplant from her husband, and was referred to our hospital. Given that the patient had anuria preoperatively, her bladder capacity was presumed to have decreased following the transplantation. There were no events regarding vascular anastomosis during the surgery...
October 2018: Hinyokika Kiyo. Acta Urologica Japonica
Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Xuejing Zhu, Hong Liu
BACKGROUND/AIMS: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied. METHODS: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Demographic and clinicopathological data were obtained within 1 month of renal biopsy...
December 7, 2018: Kidney & Blood Pressure Research
Rosanna Coppo
The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care...
November 26, 2018: Nephrology, Dialysis, Transplantation
Jonathan M Chemouny, Patrick J Gleeson, Lilia Abbad, Gabriella Lauriero, Erwan Boedec, Karine Le Roux, Céline Monot, Maxime Bredel, Julie Bex-Coudrat, Aurélie Sannier, Eric Daugas, Francois Vrtovsnik, Loreto Gesualdo, Marion Leclerc, Laureline Berthelot, Sanae Ben Mkaddem, Patricia Lepage, Renato C Monteiro
Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. We aimed to determine if an intervention targeting the gut microbiota could impact the development of disease in a humanized mouse model of IgAN, the α1KI-CD89Tg mice. Methods: Four- and 12-week old mice were divided into two groups to receive either antibiotics or vehicle control...
November 20, 2018: Nephrology, Dialysis, Transplantation
Denver D Brown, Kimberly J Reidy
The causes of macroscopic and microscopic hematuria overlap; both are often caused by urinary tract infections or urethral/bladder irritation. Coexistent hypertension and proteinuria should prompt investigation for glomerular disease. The most common glomerulonephritis in children is postinfectious glomerulonephritis. In most patients, and especially with isolated microscopic hematuria, the diagnostic workup reveals no clear underlying cause. In those cases whereby a diagnosis is made, the most common causes of persistent microscopic hematuria are thin basement membrane nephropathy, immunoglobulin A nephropathy, or idiopathic hypercalciuria...
February 2019: Pediatric Clinics of North America
Oana Nicoara, Katherine Twombley
Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. This article provides information on the pathogenesis, outcomes, and follow-up strategies that will aid in the diagnosis and referral of patients at risk for kidney disease.
February 2019: Pediatric Clinics of North America
Perrine Jullien, Blandine Laurent, François Berthoux, Ingrid Masson, Miriana Dinic, Guillaume Claisse, Damien Thibaudin, Christophe Mariat, Eric Alamartine, Nicolas Maillard
Background: The prognosis of IgA nephropathy (IgAN) is very heterogeneous. Predicting the nature and the rate of the disease progression is crucial for refining patient treatment. The aim of this study was to evaluate the prognostic impact of an Oxford classification-based repeat kidney tissue evaluation to predict end-stage renal disease (ESRD). Methods: Patients with biopsy-proven primary IgAN who underwent two renal biopsies at our centre were analyzed retrospectively...
November 15, 2018: Nephrology, Dialysis, Transplantation
Xiao-Li Li, Zhi-Gang Ma, Wen-Hui Huang, Er-Qing Chai, Yun-Fei Hao
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. The skin lesion began as an erythematous plaque and then became a blister. She also complained of abdominal distension and a decreasing urine volume. Laboratory data showed high proteinuria, hypoalbuminemia and hyperlipidemia...
November 6, 2018: World Journal of Clinical Cases
Rosanna Coppo, Graziella D'Arrigo, Giovanni Tripepi, Maria Luisa Russo, Ian S D Roberts, Shubha Bellur, Daniel Cattran, Terence H Cook, John Feehally, Vladimir Tesar, Dita Maixnerova, Licia Peruzzi, Alessandro Amore, Sigrid Lundberg, Anna Maria Di Palma, Loreto Gesualdo, Francesco Emma, Cristiana Rollino, Manuel Praga, Luigi Biancone, Antonello Pani, Sandro Feriozzi, Rosaria Polci, Jonathan Barratt, Lucia Del Vecchio, Francesco Locatelli, Alessandro Pierucci, Yasar Caliskan, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Elisabetta Moggia, José C Ballarin, Jack F M Wetzels, Dimitris Goumenos, Marios Papasotiriou, Kresimir Galesic, Luka Toric, Aikaterini Papagianni, Maria Stangou, Luisa Benozzi, Stefano Cusinato, Ulla Berg, Rezan Topaloglu, Milena Maggio, Mai Ots-Rosenberg, Marco D'Amico, Colin Geddes, Olga Balafa, Marco Quaglia, Raffaella Cravero, Calogero Lino Cirami, Bengt Fellstrom, Jürgen Floege, Jesus Egido, Francesca Mallamaci, Carmine Zoccali
Background: It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up. Methods: In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4...
November 9, 2018: Nephrology, Dialysis, Transplantation
Xuan Zhao, Daw-Yang Hwang, Hung-Ying Kao
Glucocorticoid receptor (GC), a founding member of the nuclear hormone receptor superfamily, is a glucocorticoid-activated transcription factor that regulates gene expression and controls the development and homeostasis of human podocytes. Synthetic glucocorticoids are the standard treatment regimens for proteinuria (protein in the urine) and nephrotic syndrome (NS) caused by kidney diseases. These include minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN) and immunoglobulin A nephropathy (IgAN) or subsequent complications due to diabetes mellitus or HIV infection...
2018: Nuclear Receptor Research
Jakub Ruszkowski, Katarzyna A Lisowska, Małgorzata Pindel, Zbigniew Heleniak, Alicja Dębska-Ślizień, Jacek M Witkowski
BACKGROUND: Immunoglobulin A nephropathy (IgAN), the most frequent cause of primary glomerulonephritis worldwide, is an autoimmune disease with complex pathogenesis. In this review, we focus on T cells and summarize knowledge about their involvement in pathophysiology and treatment of IgAN METHODS: We reviewed the literature for (1) alterations of T cell subpopulations in IgAN, (2) experimental and clinical proofs for T cells' participation in IgAN pathogenesis, (3) clinical correlations with T cell-associated alterations, and (4) influence of drugs used in IgAN therapy on T cell subpopulations...
November 7, 2018: Clinical and Experimental Nephrology
Stacey G Browning
Two autoimmune diseases that can negatively affect kidney function are systemic lupus erythematosus (SLE) and immunoglobulin A (IgA) nephropathy. Autoimmune diseases occur when autoantibodies attack intrinsic tissue and generate inflammation in multiple body tissues, sometimes targeting specific organs. There is no cure for either SLE or IgA nephropathy, but both disorders may be medically managed.
December 2018: Nursing Clinics of North America
Chen Huang, Xuemei Li, Jinghua Wu, Wei Zhang, Shiren Sun, Liya Lin, Xie Wang, Hongmei Li, Xiaolei Wu, Peng Zhang, Guoshuang Xu, Hanmin Wang, Hongbao Liu, Yuzhen Liu, Dapeng Chen, Li Zhuo, Wenge Li, Huanming Yang, Jian Wang, Ling Wang, Xiao Liu
Immunoglobulin A Nephropathy (IgAN) is the most common glomerulonephritis worldwide. The pathologic hallmark of IgAN is immune complex deposited in glomerular mesangium, which induces inflammation and affects the kidney's normal functions. The exact pathogenesis of IgAN, however, remains obscure. Further, in current clinical practice, the diagnosis relies on needle biopsy of renal tissue. Therefore, a non-invasive method for diagnosis and prognosis surveillance of the disease is highly desirable. To this end, we investigated the T cell receptor beta chain (TCRB) and immunoglobulin heavy chain (IGH) repertoire in circulating lymphocytes and compared them with kidney infiltrating lymphocytes using immune repertoire high throughput sequencing...
October 29, 2018: Journal of Autoimmunity
Ping Fan, Jianmin Song, Qun Chen, Xiaohong Cheng, Xusheng Liu, Chuan Zou, Bin Xie
OBJECTIVES: The effects of regional characteristics of IgAN patients in different areas of China were investigated. METHODS: Patients who were identified to have primary IgAN by renal biopsy diagnosis were recruited both from Shaanxi province hospital of traditional Chinese medicine and Guangdong province hospital of traditional Chinese medicine. Besides renal histopathology data, a number of clinical and laboratory data were collected. RESULTS: It was shown that the frequency of the patients with no mucosal infection in the urinary tract was higher in the Guangzhou group, while the frequencies of upper respiratory tract and biliary infections were lower when compared with those in the Xi'an group...
November 2018: Renal Failure
Hideo Okonogi, Tetsuya Kawamura, Kensuke Joh, Kentaro Koike, Yoichi Miyazaki, Makoto Ogura, Nobuo Tsuboi, Keita Hirano, Masato Matsushima, Takashi Yokoo, Satoshi Horikoshi, Yusuke Suzuki, Takashi Yasuda, Sayuri Shirai, Takanori Shibata, Motoshi Hattori, Yuko Akioka, Ritsuko Katafuchi, Akinori Hashiguchi, Satoshi Hisano, Akira Shimizu, Kenjiro Kimura, Shoichi Maruyama, Seiichi Matsuo, Yasuhiko Tomino
Histological classification is essential in the clinical management of immunoglobulin A nephropathy (IgAN). However, there are limitations in predicting the prognosis of IgAN based on histological information alone, which suggests the need for better prognostic models. Therefore, we defined a prognostic model by combining the grade of clinical severity with the histological grading system by the following processes. We included 270 patients and explored the clinical variables associated with progression to end-stage renal disease (ESRD)...
October 26, 2018: Clinical and Experimental Nephrology
Alaa A Ali, Dana A Sharif, Safa E Almukhtar, Kais Hasan Abd, Zana Sidiq M Saleem, Michael D Hughson
BACKGROUND: Estimates of the incidence of glomerulonephritis (GN) and end-stage renal disease (ESRD) in an Iraqi population are compared with the United States (US) and Jordan. METHODS: The study set consist of renal biopsies performed in 2012 and 2013 in the Kurdish provinces of Northern Iraq. The age specific and age standardized incidence of GN was calculated from the 2011 population. ESRD incidence was estimated from Sulaimaniyah dialysis center records of patient's inititating hemodialysis in 2017...
October 11, 2018: BMC Nephrology
Hea Min Jang, Hee Sun Baek, Jung-Eun Kim, Ju Young Kim, Yeon Hee Lee, Hee Yeon Cho, Yon Ho Choe, Ben Kang, Byung-Ho Choe, Bong Seok Choi, Min Hyun Cho
PURPOSE: The incidence of inflammatory bowel disease (IBD) is rapidly increasing, and several reports have described the renal complications of IBD. We sought to evaluate the clinical manifestations of renal complications in children with IBD in order to enable early detection and prompt treatment of the complications. METHODS: We retrospectively reviewed the medical records of 456 children and adolescents aged <20 years who had been diagnosed with IBD since 2000...
October 2018: Korean Journal of Pediatrics
F B Vincent, R Kandane-Rathnayake, A Y Hoi, L Slavin, J D Godsell, A R Kitching, J Harris, C L Nelson, A J Jenkins, A Chrysostomou, M L Hibbs, P G Kerr, M Rischmueller, F Mackay, E F Morand
INTRODUCTION: We examined the clinical relevance of urinary concentrations of B-cell-activating factor of the tumour necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) in systemic lupus erythematosus (SLE). METHODS: We quantified urinary BAFF (uBAFF) by enzyme-linked immunosorbent assay in 85 SLE, 28 primary Sjögren syndrome (pSS), 40 immunoglobulin A nephropathy (IgAN) patients and 36 healthy controls (HCs). Urinary APRIL (uAPRIL) and monocyte chemoattractant protein 1 (uMCP-1) were also quantified...
November 2018: Lupus
Ming Li, Xueqing Yu
Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulonephritis throughout the world and a major cause of end-stage renal disease among East Asian population. It is widely considered that genetic factors play an important role in the pathogenesis of IgAN. The genetic studies of IgAN, is from the association studies of candidate genes and family-based designs, to the genome-wide association studies. Altogether there are five large genome-wide association studies performed, which have identified multiple susceptibility loci for IgAN, including several novel loci found in Chinese population...
October 2018: Nephrology
Yue-Miao Zhang, Hong Zhang
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and the most common cause of end-stage renal disease in young adults. However, there are still no specific therapies capable of targeting key pathways involved in disease pathogenesis. Recently, many large randomized controlled trials have been reported, such as Supportive Versus Immunosuppressive Therapy for the Treatment of Progressive IgA Nephropathy, Targeted-release Budesonide Versus Placebo in Patients with IgA Nephropathy and Therapeutic Evaluation of Steroids in IgA Nephropathy Global, which are considered to update the 2012 Kidney Disease: Improving Global Outcomes Guideline...
October 2018: Nephrology
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