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Aminoglycoside resistance

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https://www.readbyqxmd.com/read/30553930/emergence-in-japan-of-an-isolate-of-klebsiella-pneumoniae-co-harboring-bla-kpc-2-and-rmtb
#1
Hiroki Uchida, Tatsuya Tada, Mari Tohya, Yoshie Sugahara, Akira Kato, Isao Miyairi, Teruo Kirikae
OBJECTIVES: The aim of this study was to report that a clinical isolate of K. pneumoniae ST11 harbored both blaKPC-2 and rmtB in Japan. METHODS: A carbapenem and aminoglycoside-resistant Klebsiella pneumoniae was isolated from an inpatient in Japan. The whole genome was sequenced by a next generation sequencer. RESULTS: The minimum inhibitory concentrations of meropenem and amikacin were ≥512μg/ml each. Whole-genome sequence analysis revealed that the isolate harbored both blaKPC-2 and rmtB...
December 13, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/30544654/modulation-of-the-antibiotic-activity-by-the-mauritia-flexuosa-buriti-fixed-oil-against-methicillin-resistant-staphylococcus-aureus-mrsa-and-other-multidrug-resistant-mdr-bacterial-strains
#2
Yara Faustino Pereira, Maria do Socorro Costa, Saulo Relison Tintino, Janaína Esmeraldo Rocha, Fábio Fernandes Galvão Rodrigues, Maria Karine de Sá Barreto Feitosa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Erlânio Oliveira de Sousa
Mauritia flexuosa (buriti) is a typical Brazilian palm tree found in swampy regions with many plant forms. The fruit has various purposes with the pulps to the seeds being used for ice creams, sweets, creams, jellies, liqueurs, and vitamin production. A physicochemical characterization of the fixed pulp oil and its antibacterial and aminoglycoside antibiotic modifying activity against Gram-positive and Gram-negative multiresistant bacterial strains were performed using broth microdilution assays. Physical properties, such as moisture, pH, acidity, peroxide index, relative density, and refractive index, indicated oil stability and chemical quality...
December 10, 2018: Pathogens
https://www.readbyqxmd.com/read/30544256/the-application-of-antibiotics-in-broiler-production-and-the-resulting-antibiotic-resistance-in-escherichia-coli-a-global-overview
#3
Nataliya Roth, Annemarie Käsbohrer, Sigrid Mayrhofer, Ulrike Zitz, Charles Hofacre, Konrad J Domig
The increase in antibiotic resistance is a global concern for human and animal health. Resistant microorganisms can spread between food-producing animals and humans. The objective of this review was to identify the type and amount of antibiotics used in poultry production and the level of antibiotic resistance in Escherichia coli isolated from broilers. Isolate information was obtained from national monitoring programs and research studies conducted in large poultry-producing regions: US, China, Brazil, and countries of EU-Poland, United Kingdom, Germany, France, and Spain...
December 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/30543470/endemicity-of-the-high-risk-clone-klebsiella-pneumoniae-st340-coproducing-qnrb-ctx-m-15-and-kpc-2-in-a-brazilian-hospital
#4
Fernanda Modesto Tolentino, Maria Fernanda Campagnari Bueno, Gabriela Rodrigues Franscisco, Diego Diniz de Paula Barcelos, Suzana Margareth Lobo, Francieli Maira Moreira Batista Tomaz, Natal Santos da Silva, Leonardo Neves de Andrade, Tiago Casella, Ana Lucia da Costa Darini, Milena Polotto, Doroti de Oliveira Garcia, Mara Correa Lelles Nogueira
The dissemination of multiresistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing Klebsiella pneumoniae isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant K. pneumoniae isolated from 2011 to 2014 in a tertiary hospital were investigated. The blaKPC-2 gene was the only determinant for carbapenem resistance. The blaCTX-M-15 gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas aph(3')-Ia and qnrB were the most common genes associated with resistance to aminoglycosides and quinolones, respectively...
December 13, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30540076/characterisation-of-plasmid-mediated-rmtb-1-in-enterobacteriaceae-clinical-isolates-from-s%C3%A3-o-paulo-brazil
#5
Dandara Cassu-Corsi, Willames Mbs Martins, Adriana G Nicoletti, Luiz Gp Almeida, Ana Tr Vasconcelos, Ana C Gales
OBJECTIVES The emergence of 16S rRNA methyltranferases (16 RMTAses) has jeopardised the clinical use of aminoglycosides. RmtB is one of the most frequently reported in Gram-negatives worldwide. In this study, we aimed to estimate the frequency of 16S RMTAses encoding genes in Enterobacteriaceae isolated in a three-month period from a tertiary Brazilian hospital. METHODS All Gram-negatives classified as resistant to amikacin, gentamicin, and tobramycin by agar screening were selected for analysis. The presence of 16SRMTases encoding genes was verified by polymerase chain reaction (PCR)...
December 10, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/30532201/a-genome-wide-association-analysis-reveals-a-potential-role-for-recombination-in-the-evolution-of-antimicrobial-resistance-in-burkholderia-multivorans
#6
Julio Diaz Caballero, Shawn T Clark, Pauline W Wang, Sylva L Donaldson, Bryan Coburn, D Elizabeth Tullis, Yvonne C W Yau, Valerie J Waters, David M Hwang, David S Guttman
Cystic fibrosis (CF) lung infections caused by members of the Burkholderia cepacia complex, such as Burkholderia multivorans, are associated with high rates of mortality and morbidity. We performed a population genomics study of 111 B. multivorans sputum isolates from one CF patient through three stages of infection including an early incident isolate, deep sampling of a one-year period of chronic infection occurring weeks before a lung transplant, and deep sampling of a post-transplant infection. We reconstructed the evolutionary history of the population and used a lineage-controlled genome-wide association study (GWAS) approach to identify genetic variants associated with antibiotic resistance...
December 7, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/30530220/biofilms-in-hospital-effluents-as-a-potential-crossroads-for-carbapenemase-encoding-strains
#7
J Ory, G Bricheux, F Robin, A Togola, C Forestier, O Traore
Bacterial resistance to carbapenem, which is mainly due to the successful dissemination of carbapenemase-encoding genes, has become a major health problem. Few studies have aimed to characterize the level of resistance in the environment, notably in hospital wastewater, which is a likely hotspot for exchange of antibiotic resistance genes. In this work, we looked for the presence of imipenem-resistant bacteria and imipenem in the effluent of the teaching hospital of Clermont-Ferrand, France. Selective growth of bacteria from 14-day old biofilms formed in the pipe sewer showed that 22...
December 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30530174/synthesis-antimicrobial-activity-attenuation-of-aminoglycoside-resistance-in-mrsa-and-ribosomal-a-site-binding-of-pyrene-neomycin-conjugates
#8
Sandra Story, Michael J Skriba, Krishnagopal Maiti, Nihar Ranjan, Natalya N Degtyareva, Keith D Green, Verjine Khodaverdian, Adegboyega K Oyelere, Sylvie Garneau-Tsodikova, Dev P Arya
The development of new ligands that have comparable or enhanced therapeutic efficacy relative to current drugs is vital to the health of the global community in the short and long term. One strategy to accomplish this goal is to functionalize sites on current antimicrobials to enhance specificity and affinity while abating resistance mechanisms of infectious organisms. Herein, we report the synthesis of a series of pyrene-neomycin B (PYR-NEO) conjugates, their binding affinity to A-site RNA targets, resistance to aminoglycoside-modifying enzymes (AMEs), and antibacterial activity against a wide variety of bacterial strains of clinical relevance...
November 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30523288/the-prevalence-of-mitochondrial-mutations-associated-with-aminoglycoside-induced-deafness-in-ethnic-latvian-population-the-appraisal-of-the-evidence
#9
Viktorija Igumnova, Lauma Veidemane, Anda Vīksna, Valentina Capligina, Egija Zole, Renate Ranka
Aminoglycosides are potent antibiotics which are used to treat severe gram-negative infections, neonatal sepsis, and multidrug-resistant tuberculosis. Ototoxicity is a well-known side effect of aminoglycosides, and a rapid, profound, and irreversible hearing loss can occur in predisposed individuals. MT-RNR1 gene encoding the mitochondrial ribosomal 12S subunit is a hot spot for aminoglycoside-induced hearing loss mutations, however, a variability in the nature and frequency of genetic changes in different populations exists...
December 6, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/30511766/plazomicin-a-next-generation-aminoglycoside
#10
Kristy M Shaeer, Monika T Zmarlicka, Elias B Chahine, Nicholas Piccicacco, Jonathan C Cho
Plazomicin is a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thus inhibiting protein synthesis via a concentration-dependent manner. Plazomicin displays a broad spectrum of activity against aerobic gram-negative bacteria, including extended-spectrum β-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, and organisms with aminoglycoside-modifying enzymes. In a large phase III clinical trial, plazomicin was shown to be noninferior to meropenem in the treatment of complicated urinary tract infections (cUTI) with respect to the coprimary efficacy endpoints of the microbiologically modified intent-to-treat composite cure rate at day 5 (plazomicin 88% [n=168/191] vs meropenem 91...
December 4, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30511216/co-production-of-ampc-and-extended-spectrum-beta-lactamases-in-cephalosporin-resistant-acinetobacter-baumannii-in-egypt
#11
Heba Shehta Said, Abdalbagi Basheer Benmahmod, Ramadan Hassan Ibrahim
Acinetobacter baumannii is an opportunistic pathogen that has been held responsible for a lot of infections worldwide. Infections caused by this pathogen are difficult to control because of the widespread of antimicrobial resistance mechanisms. The aim of the present study is to assess the prevalence of extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases among isolates of A. baumannii collected from different clinical sources in Mansoura University Hospitals, Egypt. Antimicrobial susceptibility testing has demonstrated elevated resistance level to β-lactams, quinolones and aminoglycosides...
December 3, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/30511081/troxerutin-down-regulates-kim-1-modulates-p38-mapk-signaling-and-enhances-renal-regenerative-capacity-in-a-rat-model-of-gentamycin-induced-acute-kidney-injury
#12
Samir A Salama, Hany H Arab, Ibrahim A Maghrabi
Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas species. The clinical use of gentamycin is substantially limited by its side effects particularly acute kidney injury (AKI). The aim of the current study was to investigate the protective effect of the plant flavonoid troxerutin (150 mg kg-1 day-1 for 15 days) against gentamycin-induced AKI using Wistar rats as an experimental mammalian model...
December 4, 2018: Food & Function
https://www.readbyqxmd.com/read/30507374/characterization-of-a-multidrug-resistant-klebsiella-pneumoniae-st607-k25-clone-responsible-for-a-nosocomial-outbreak-in-a-neonatal-intensive-care-unit
#13
F Peltier, M Choquet, V Decroix, C C Adjidé, S Castelain, R Guiheneuf, E Pluquet
PURPOSE: Multidrug-resistant Klebsiella pneumoniae strains are regularly involved in hospital outbreaks. This study describes an ESBL-producing K. pneumoniae clone (ST607-K25) responsible for a nosocomial outbreak in a neonatal intensive care unit. METHODOLOGY: Fourteen strains isolated from 13 patients were included. Antimicrobial susceptibility testing was performed by the agar diffusion method. A clonal link was first investigated by fingerprinting (ERIC-PCR and REP-PCR) then confirmed by MLST...
December 3, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/30499420/high-level-aminoglycoside-resistance-in-enterococcus-faecalis-and-enterococcus-faecium-as-a-serious-threat-in-hospitals
#14
Mahmoud Khodabandeh, Mohsen Mohammadi, Mohammad Reza Abdolsalehi, Meysam Hasannejad-Bibalan, Mehrdad Gholami, Azadeh Alvandimanesh, Abazar Pournajaf, Ramazan Rajabnia
The present work aimed to evaluate the frequency of aminoglycoside-modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. A total of 305 different clinical samples were subjected for identification and antibiotic susceptibility test. High level aminoglycoside resistance was identified by MIC and Kirby Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')-Ia genes were determined by multiplex- PCR. In total 100 enterococci strains were isolated...
November 29, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/30499362/adverse-effects-of-aminoglycosides-in-children-with-drug-resistant-tuberculosis
#15
Ira Shah, Anmol Goyal, Naman S Shetty
No abstract text is available yet for this article.
November 30, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/30497989/screening-of-tropical-estuarine-water-in-south-west-coast-of-india-reveals-emergence-of-args-harboring-hypervirulent-escherichia-coli-of-global-significance
#16
Sukumaran P Divya, A A Mohamed Hatha
The goal of this study was to investigate the involvement of a tropical Indian estuary in the emergence of antibiotic resistance genes (ARGs)-harboring hypervirulent E. coli of global significance. A total of 300 E. coli isolates was tested for antibiotic susceptibility to β-lactams, aminoglycosides, chloramphenicol, quinolones, sulphonamides, tetracyclines, and trimethoprim. The E. coli isolates were screened for the presence of antibiotic resistance genes (blaTEM , blaCTX-M , tetA, tetB, sul1, sul2, strA, aphA2, catI, dhfr1, and dhfr7), integrase (int1, int2, and int3), Shiga toxin genes (stx1 and stx2) and extraintestinal virulence genes (papAH, papC, sfa/focDE, kpsMT II, and iutA)...
November 26, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/30496227/development-of-actionable-quality-indicators-and-an-action-implementation-toolbox-for-appropriate-antibiotic-use-at-intensive-care-units-a-modified-rand-delphi-study
#17
Marlot C Kallen, Marie-Jose Roos-Blom, Dave A Dongelmans, Jeroen A Schouten, Wouter T Gude, Evert de Jonge, Jan M Prins, Nicolette F de Keizer
INTRODUCTION: Extensive antibiotic use makes the intensive care unit (ICU) an important focus for antibiotic stewardship programs. The aim of this study was to develop a set of actionable quality indicators for appropriate antibiotic use at ICUs and an implementation toolbox, which can be used to assess and improve the appropriateness of antibiotic use in the treatment of adult patients at an ICU. METHODS: A four round modified-RAND Delphi procedure was used. Potential indicators were identified by a multidisciplinary panel of 15 Dutch experts, from international literature and guidelines...
2018: PloS One
https://www.readbyqxmd.com/read/30486311/multidrug-resistant-gram-negative-bacilli-a-retrospective-study-of-trends-in-a-tertiary-healthcare-unit
#18
Delia Muntean, Florin-George Horhat, Luminița Bădițoiu, Victor Dumitrașcu, Iulia-Cristina Bagiu, Delia-Ioana Horhat, Dan A Coșniță, Anca Krasta, Dorina Dugăeşescu, Monica Licker
Background and objective: Bacterial multidrug resistance is particularly common in Gram-negative bacilli (GNB), with important clinical consequences regarding their spread and treatment options. The aim of this study was to investigate the trend of multidrug-resistant GNB (MDR-GNB) in high-risk hospital departments, between 2000⁻2015, in intervals of five years, with the intention of improving antibiotic therapy policies and optimising preventive and control practices. Materials and methods: This is an observational, retrospective study performed in three departments of the most important tertiary healthcare unit in the southwestern part of Romania: the Intensive Care Unit (ICU), the General Surgery Department (GSD), and the Nutrition and Metabolic Diseases Department (NMDD)...
November 26, 2018: Medicina
https://www.readbyqxmd.com/read/30481921/-preliminary-study-on-resistance-mechanism-and-virulence-features-in-carbapenems-resistant-klebsiella-pneumoniae-from-burn-patients
#19
Z Chen, J Xiang
Objective: To investigate resistance mechanism and virulence features of carbapenems-resistant Klebsiella pneumoniae (CRKP) and to provide theoretical foundation for the prevention and control of nosocomial infections in burn wards as well as clinical therapy of CRKP. Methods: Strains of Klebsiella pneumoniae isolated from clinical samples of burn patients hospitalized in our unit from February to December 2016 were collected. The diameters of inhibition zone of imipemen or meropenem susceptibility disk of the above strains were≤22 mm...
November 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/30481054/salmonella-prevalence-and-antimicrobial-drug-resistance-in-dual-purpose-cattle-operations-in-the-eastern-region-of-zulia-state-venezuela
#20
Yrimar Fuenmayor, Argenis Rodas-González, Gabriela Carruyo, Armando E Hoet, Thomas Wittum, Claudia Narváez-Bravo
To evaluate the Salmonella prevalence and its antimicrobial susceptibility in dual-purpose cattle farms, fecal (n = 3964; from cows and calves) and environmental samples (n = 334; personnel, feed, and water sources) were collected over a 1-year period at six farms in the eastern region of Zulia State, Venezuela. Salmonella detection was carried out using standard microbiological culture methods. From 453 isolated Salmonella, antimicrobial susceptibility was tested using a panel of 10 antibiotics by the disk diffusion test method...
November 27, 2018: Foodborne Pathogens and Disease
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