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Keith Poole

Sarah Stewart, Angela Brenton-Rule, Nicola Dalbeth, Ashok Aiyer, Christopher Frampton, Keith Rome
OBJECTIVE: To determine characteristics of the foot and ankle in people with systemic lupus erythematosus (SLE). METHODS: Medline, CINAHL, Sports-Discus, Scopus and Cochrane Library databases were searched up to January 2018. Studies reporting foot- and ankle-related outcomes in the following domains were included: vascular, neurological, musculoskeletal, cutaneous (skin and nail) or pain/function. The Quality Index tool was used to assess methodological quality...
August 6, 2018: Seminars in Arthritis and Rheumatism
Axel Hauschild, James Larkin, Antoni Ribas, Brigitte Dréno, Keith T Flaherty, Paolo A Ascierto, Karl D Lewis, Edward McKenna, Qian Zhu, Yong Mun, Grant A McArthur
Importance: Prognostic models may provide insight into clinical trial results and inform the clinical management of patients with BRAF V600-mutated metastatic melanoma. Objective: To identify subgroups with distinct survival outcomes based on clinical and genomic characteristics and to assess survival in identified prognostic subgroups across cohorts treated with dacarbazine, vemurafenib, or cobimetinib plus vemurafenib. Design, Setting, and Participants: This retrospective and exploratory recursive partitioning analysis (RPA) modeled associations between prespecified covariates and survival outcomes using pooled data from the BRIM-2, BRIM-3, BRIM-7, and coBRIM studies...
August 2, 2018: JAMA Oncology
Courtland S Hyatt, Chelsea E Sleep, Joanna Lamkin, Jessica L Maples-Keller, Constantine Sedikides, W Keith Campbell, Joshua D Miller
Similarity between narcissism and self-esteem seems intuitive, as both capture positive perceptions of the self. In the current undertaking, we provide a broad comparison of the nomological networks of grandiose narcissism and explicit self-esteem. Pooling data from 11 existing samples (N = 4711), we compared the relations of narcissism and self-esteem to developmental experiences, individual differences, interpersonal functioning, and psychopathology. Both constructs are positively related to agentic traits and assertive interpersonal approaches, but differ in relation to agreeableness/communion...
2018: PloS One
Keith R Martin, Kaweh Mansouri, Robert N Weinreb, Robert Wasilewicz, Christophe Gisler, Jean Hennebert, Dominique Genoud
PURPOSE: To test the hypothesis that contact lens sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open angle glaucoma (POAG) and healthy (H) eyes. DESIGN: Development and evaluation of a diagnostic test with machine learning. SUBJECTS: From 435 subjects (193 healthy and 242 POAG), 136 POAG and 136 age-matched healthy subjects were selected...
July 24, 2018: American Journal of Ophthalmology
Yuxin Liu, Keith Sigel, Michael M Gaisa
Background: High-risk human papillomavirus (hrHPV)-induced anal low-grade squamous intraepithelial lesions (LSIL) have the potential to progress to high-grade SIL (HSIL). We investigated whether anal hrHPV infections, particularly types 16 and 18, predict LSIL-to-HSIL progression. Methods: 146 HIV-infected and 22 HIV-uninfected patients with anal LSIL underwent cytology, HPV genotyping (16, 18, and pooled 12 hrHPV), and high-resolution anoscopy-guided biopsy at baseline and surveillance...
July 21, 2018: Journal of Infectious Diseases
Álvaro H Borges, Jacqueline Neuhaus, Shweta Sharma, James D Neaton, Keith Henry, Olga Anagnostou, Teresa Staub, Sean Emery, Jens D Lundgren
Background: Pooled data from SMART and START were used to compare deferred/intermittent versus immediate/continuous antiretroviral therapy (ART) on disease risk. Methods: Endpoints assessed were AIDS, serious non-AIDS (SNA), cardiovascular disease (CVD), cancer, and death. Pooled (stratified by study) hazard ratios (HRs) from Cox models were obtained for deferred/intermittent ART vs immediate/continuous ART; analyses were conducted to assess consistency of HRs across baseline-defined subgroups...
July 19, 2018: Journal of Infectious Diseases
Keith R Laws, Nicole Darlington, Tejinder K Kondel, Peter J McKenna, Sameer Jauhar
BACKGROUND: The effect of cognitive behavioural therapy for psychosis (CBTp) on the core symptoms of schizophrenia has proven contentious, with current meta-analyses finding at most only small effects. However, it has been suggested that the effects of CBTp in areas other than psychotic symptoms are at least as important and potentially benefit from the intervention. METHOD: We meta-analysed RCTs investigating the effectiveness of CBTp for functioning, distress and quality of life in individuals diagnosed with schizophrenia and related disorders...
July 17, 2018: BMC Psychology
Dipti Pawaskar, Michael A Tortorici, Bruce Zuraw, Timothy Craig, Marco Cicardi, Hilary Longhurst, H Henry Li, William R Lumry, Inmaculada Martinez-Saguer, Joshua Jacobs, Jonathan A Bernstein, Marc A Riedl, Constance H Katelaris, Paul K Keith, Annette Feussner, Jagdev Sidhu
BACKGROUND: Long-term prophylaxis with subcutaneous (SC) administration of a highly concentrated plasma-derived C1 esterase inhibitor (C1-INH) formulation was recently approved by the Food and Drug Administration for hereditary angioedema (HAE) attack prevention. OBJECTIVE: To characterize the population pharmacokinetics of C1-INH (SC) (HAEGARDA® ; CSL Behring) in healthy volunteers and HAE patients, and assess the variability and influence of covariates on pharmacokinetics...
July 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Michele Di Mascio, Sharat Srinivasula, Insook Kim, Gorka Duralde, Alexis St Claire, Paula DeGrange, Marisa St Claire, Keith A Reimann, Erin E Gabriel, Jorge Carrasquillo, Richard C Reba, Chang Paik, Henry C Lane
The peripheral blood represents only a small fraction of the total number of lymphocytes in the body. To develop a more thorough understanding of T cell dynamics, including the effects of SIV/SHIV/HIV infection on immune cell depletion and immune reconstitution following combination antiretroviral therapy (cART), one needs to utilize approaches that allow direct visualization of lymphoid tissues. In the present study, noninvasive in vivo imaging of the CD4+ T cell pool has revealed that the timing of the CD4+ T cell pool reconstitution following initiation of ART in SIV-infected nonhuman primates (NHPs) appears seemingly stochastic among clusters of lymph nodes within the same host...
July 12, 2018: JCI Insight
Ajai Chari, A Keith Stewart, Stuart D Russell, Philippe Moreau, Joerg Herrmann, Jose Banchs, Roman Hajek, John Groarke, Alexander R Lyon, George N Batty, Sunhee Ro, Mei Huang, Karim S Iskander, Daniel Lenihan
Carfilzomib is a selective proteasome inhibitor approved for the treatment of relapsed and/or refractory multiple myeloma (RRMM). It has significantly improved outcomes, including overall survival (OS), and shown superiority vs standard treatment with lenalidomide plus dexamethasone and bortezomib plus dexamethasone. The incidence rate of cardiovascular (CV) events with carfilzomib treatment has varied across trials. This analysis evaluated phase 1-3 trials with >2000 RRMM patients exposed to carfilzomib to describe the incidence of CV adverse events (AEs)...
July 10, 2018: Blood Advances
Nicholas R LaBonte, Peng Zhao, Keith Woeste
Chestnuts ( Castanea ) are major nut crops in East Asia and southern Europe, and are unique among temperate nut crops in that the harvested seeds are starchy rather than oily. Chestnut species have been cultivated for three millennia or more in China, so it is likely that artificial selection has affected the genome of orchard-grown chestnuts. The genetics of Chinese chestnut ( Castanea mollissima Blume) domestication are also of interest to breeders of hybrid American chestnut, especially if the low-growing, branching habit of Chinese chestnut, an impediment to American chestnut restoration, is partly the result of artificial selection...
2018: Frontiers in Plant Science
Carsten Kröger, Keith D MacKenzie, Ebtihal Y Alshabib, Morgan W B Kirzinger, Danae M Suchan, Tzu-Chiao Chao, Valentyna Akulova, Aleksandra A Miranda-CasoLuengo, Vivian A Monzon, Tyrrell Conway, Sathesh K Sivasankaran, Jay C D Hinton, Karsten Hokamp, Andrew D S Cameron
We present the first high-resolution determination of transcriptome architecture in the priority pathogen Acinetobacter baumannii. Pooled RNA from 16 laboratory conditions was used for differential RNA-seq (dRNA-seq) to identify 3731 transcriptional start sites (TSS) and 110 small RNAs, including the first identification in A. baumannii of sRNAs encoded at the 3' end of coding genes. Most sRNAs were conserved among sequenced A. baumannii genomes, but were only weakly conserved or absent in other Acinetobacter species...
July 9, 2018: Nucleic Acids Research
Joshua L Chan, Justin G Miller, Avneesh K Singh, Keith A Horvath, Philip C Corcoran, Muhammad M Mohiuddin
The field of cardiac xenotransplantation has entered an exciting era due to recent advances in the field. Although several hurdles remain, the use of rapidly evolving transgenic technology has the potential to address current allogeneic donor pool constraints and mechanical circulatory system device limitations. The success of xenotransplantation will undoubtedly be dependent on specific patient selection criteria. Defining these particular indications for xenotransplantation is important as we approach the possibility of clinical applications...
June 29, 2018: Clinical Transplantation
Ian Needleman, Raul Garcia, Nikos Gkranias, Keith L Kirkwood, Thomas Kocher, Anna Di Iorio, Federico Moreno, Aviva Petrie
BACKGROUND: Rate of progression of periodontitis has been used to inform the design of classifications of periodontal diseases. However, the evidence underpinning this topic is unclear and no systematic review has yet been conducted. OBJECTIVES: The focused question for this systematic review was: in adults, what is the progression of periodontitis in terms of clinical attachment loss, radiographic bone loss, and tooth loss? DATA SOURCES: Highly sensitive electronic search was conducted for published data in MEDLINE, EMBASE, LILACS, and unpublished grey literature in OpenGrey up to February 2016...
June 2018: Journal of Periodontology
Ian Needleman, Raul Garcia, Nikos Gkranias, Keith L Kirkwood, Thomas Kocher, Anna Di Iorio, Federico Moreno, Aviva Petrie
BACKGROUND: Rate of progression of periodontitis has been used to inform the design of classifications of periodontal diseases. However, the evidence underpinning this topic is unclear and no systematic review has yet been conducted. OBJECTIVES: The focused question for this systematic review was: in adults, what is the progression of periodontitis in terms of clinical attachment loss, radiographic bone loss, and tooth loss? DATA SOURCES: Highly sensitive electronic search was conducted for published data in MEDLINE, EMBASE, LILACS, and unpublished grey literature in OpenGrey up to February 2016...
June 2018: Journal of Clinical Periodontology
Alexander L Greninger, Pavitra Roychoudhury, Hong Xie, Amanda Casto, Anne Cent, Gregory Pepper, David M Koelle, Meei-Li Huang, Anna Wald, Christine Johnston, Keith R Jerome
Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We report the development and validation of a DNA oligonucleotide hybridization panel to recover nearly complete HSV genomes at abundances up to 50,000-fold lower than previously reported. Using copy number information on herpesvirus and host DNA background via quantitative PCR, we developed a protocol for pooling for cost-effective recovery of more than 50 HSV-1 or HSV-2 genomes per MiSeq run...
June 27, 2018: MSphere
Donagh A Healy, Shiori Kimura, David Power, Abubaker Elhaj, Yasser Abdeldaim, Keith S Cross, Gerard T McGreal, Paul E Burke, Tony Moloney, Brian J Manning, Eamon G Kavanagh
OBJECTIVES: A systematic review and meta-analysis was performed to determine the incidence of thrombotic events following great saphenous vein (GSV) endovenous thermal ablation (EVTA). METHODS: MEDLINE, Embase and conference abstracts were searched. Eligible studies were randomised controlled trials and case series that included at least 100 patients who underwent GSV EVTA (laser ablation or radiofrequency ablation [RFA]) with duplex ultrasound (DUS) within 30 days...
June 9, 2018: European Journal of Vascular and Endovascular Surgery
Dora Henriques, Keith A Browne, Mark W Barnett, Melanie Parejo, Per Kryger, Tom C Freeman, Irene Muñoz, Lionel Garnery, Fiona Highet, J Spencer Jonhston, Grace P McCormack, M Alice Pinto
The natural distribution of the honeybee (Apis mellifera L.) has been changed by humans in recent decades to such an extent that the formerly widest-spread European subspecies, Apis mellifera mellifera, is threatened by extinction through introgression from highly divergent commercial strains in large tracts of its range. Conservation efforts for A. m. mellifera are underway in multiple European countries requiring reliable and cost-efficient molecular tools to identify purebred colonies. Here, we developed four ancestry-informative SNP assays for high sample throughput genotyping using the iPLEX Mass Array system...
June 4, 2018: Scientific Reports
Aline Jelenkovic, Janne Mikkonen, Pekka Martikainen, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Eero Vuoksimaa, Esther Rebato, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Robert F Krueger, Matt McGue, Shandell Pahlen, Tracy L Nelson, Keith E Whitfield, Ingunn Brandt, Thomas S Nilsen, Jennifer R Harris, Tessa L Cutler, John L Hopper, Adam D Tarnoki, David L Tarnoki, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
BACKGROUND: There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. METHODS: The data were derived from nine twin cohorts in eight countries including 6116 complete twin pairs...
May 30, 2018: Journal of Epidemiology and Community Health
Kurtis Poole, Keith Couper, Michael A Smyth, Joyce Yeung, Gavin D Perkins
In cardiac arrest, high quality cardiopulmonary resuscitation (CPR) is a key determinant of patient survival. However, delivery of effective chest compressions is often inconsistent, subject to fatigue and practically challenging.Mechanical CPR devices provide an automated way to deliver high-quality CPR. However, large randomised controlled trials of the routine use of mechanical devices in the out-of-hospital setting have found no evidence of improved patient outcome in patients treated with mechanical CPR, compared with manual CPR...
May 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
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