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Papillary Tumors Of Salivary Gland

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https://www.readbyqxmd.com/read/30078266/-clinicopathologic-and-molecular-genetic-analysis-of-secretory-carcinoma-of-salivary-gland
#1
M Zhao, D H Zhao, G Cheng, Y J Yan, Z Wang, X L He
Objective: To investigate the clinicopathologic and molecular genetic features of secretory carcinoma of salivary gland (SCSG). Methods: Six cases of SCSG were collected from Zhejiang Provincial People ' s Hospital from January 2011 to March 2018. The clinical, histopathological and immunohistochemical features were analyzed and fluorescence in situ hybridization (FISH) was used to detect ETV6 gene rearrangement. Results: Four out of 6 tumors originated in the parotid gland and one of each in the minor salivary glands of soft palate and the buccal mucosa...
August 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/30046434/incidence-of-second-malignancy-in-patients-with-papillary-thyroid-cancer-from-surveillance-epidemiology-and-end-results-13-dataset
#2
Mayumi Endo, Jessica B Liu, Marcelle Dougan, Jennifer S Lee
Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O/E) of 1.16 (95% CI; 1.12-1.21). Bone and joint cancer had the highest O/E ratio of 4...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/30036439/warthin-tumor-of-the-larynx-a-case-report-and-review-of-the-literature
#3
Irit Duek, Miki Paker, Ziv Gil, Jacob T Cohen
Warthin tumor (papillary cystadenoma lymphomatosum) is a benign salivary gland tumor that occurs almost exclusively in the parotid gland. As far as we know, only 15 cases of laryngeal Warthin tumor have been previously reported worldwide. We describe the case of a 75-year-old woman with a supraglottic tumor that mimicked a mucoepidermoid carcinoma. The tumor was completely excised via a transcervical approach. Pathology identified it as a Warthin tumor. At follow-up, the patient maintained good oral intake...
July 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29900928/cystadenocarcinoma-of-the-mandible
#4
Jinisha Madathil, Nileena R Kumar, P Shiny
Papillary cystadenocarcinoma of the salivary gland is a rare malignant tumor and occurs in major and minor salivary glands. Papillary cystadenocarcinoma of the mandible is exceptionally rare. It is usually a low-grade destructive tumor with a papillary and cystic architecture. This case describes a unique presentation, location, and radiographic appearance of this lesion.
May 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29768362/intraductal-papilloma-arising-from-the-accessory-parotid-gland-a-case-report-and-literature-review
#5
REVIEW
Shuai Sun, Panpan Wang, Yufan Wang, Wen Su, Feng Wang, Hongyu Yang
RATIONALE: Intraductal papillomas of the accessory parotid glands are extremely rare benign tumors that are most commonly derived from minor salivary glands and are easily misdiagnosed as other diseases. Studying these lesions by pathology and immunohistochemistry can raise awareness of the disease, reduce the rate of misdiagnosis, and provide more precise treatments. PATIENT CONCERNS: A 35-year-old man first presented to our hospital with a 6-month history of a painless mass on his left parotid gland...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#6
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
August 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683815/salivary-secretory-carcinoma-with-a-novel-etv6-met-fusion-expanding-the-molecular-spectrum-of-a-recently-described-entity
#7
Lisa M Rooper, Theodoros Karantanos, Yi Ning, Justin A Bishop, Sarah W Gordon, Hyunseok Kang
Secretory carcinoma of the salivary glands, also known as mammary analogue secretory carcinoma, is a recently described tumor characterized by generally indolent clinical behavior and recurrent ETV6-NTRK3 fusions. However, a small subset of recent cases with high-grade histology, aggressive behavior, or alternate molecular findings are expanding the spectrum of this entity. In this case, a 59-year-old female presented with an infiltrative submandibular gland tumor that was originally classified as a high-grade acinic cell carcinoma, papillary-cystic variant...
August 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29594833/palatal-polymorphous-adenocarcinoma-with-high-grade-transformation-a-case-report-and-literature-review
#8
Kentaro Kikuchi, Toshitaka Nagao, Fumio Ide, Shota Takizawa, Hideaki Sakashita, Ichiro Tsujino, Tie-Jun Li, Kaoru Kusama
Polymorphous adenocarcinoma (PAC) is the second most common intraoral malignant neoplasm of the minor salivary glands. However, it is very rare for PAC to show high-grade transformation (HGT) and to our knowledge, the English literature only seven reported cases. HGT tends to be observed when PAC recurs, and it is extremely rare to be seen at initial presentation. Here we report a 43-year-old Japanese male patient with PAC of the right palate showing HGT at initial presentation. Histopathologically, the tumor was characterized by a prominent solid and papillary-cystic growth pattern, with nuclear atypia and necrosis in area of HGT...
March 29, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29403174/papillary-pattern-in-acinic-cell-carcinoma-of-parotid-gland-a-potential-diagnostic-pitfall-on-fnac
#9
Anju Bansal, Manveen Kaur, Varsha Dalal, Fouzia Siraj
Fine needle aspiration cytology (FNAC) is often the first investigation in the work up of salivary gland lesions. However, its diagnostic accuracy is limited by the high rates of false positives and false negatives. Usually, acinic cell carcinoma is prone to be underdiagnosed because of the cytological similarity of the tumor cells to normal acinar cells, however rarely, a predominant papillary architecture on cytology may cause confusion with adenocarcinomas. We present a case of a 45-year-old male with a painful swelling of the right parotid region...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29399982/warthins-tumor-cyto-histological-spectrum-with-emphasis-on-diagnostic-difficulties
#10
Neelam Sood, Parismrita Borah
Warthins tumour is characterized by the presence of epithelial proliferation in a lymphoid stroma. It has been categorized as Sieferts types: 1-4, depending on the proportions of the 2 components. Although FNA is fairly accurate in establishing the diagnosis, the cytologic diagnosis of this tumor has potential sources of error. This retrospective study was conducted in the Department of Pathology and Lab Medicine, of a tertiary care hospital. Cytology and surgical pathology records of past 15 years were screened...
July 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29228842/mammary-analogue-secretory-carcinoma-of-the-thyroid-mimicking-locally-advanced-papillary-thyroid-carcinoma-a-rare-case-report
#11
Haihui Liao, Ashraf Khan, Patricia M Miron, Kristine M Cornejo
Mammary analogue secretory carcinoma (MASC) harboring ETV6 gene rearrangements was first described in the salivary gland with a relatively favorable prognosis and a possible molecular therapeutic target with pan-Trk inhibitors. Recently, primary MASC of the thyroid gland has been reported. We report a case of a 4.0 cm MASC arising from the left thyroid of a 58-year-old female with extrathyroidal extension. Initially, it was diagnosed by fine needle aspiration as suspicious for papillary thyroid carcinoma (PTC) and subsequently called a poorly differentiated carcinoma on resection...
August 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29139086/diagnostic-approaches-for-salivary-gland-tumors-with-secretory-and-microcystic-features
#12
Ha Young Woo, Eun Chang Choi, Sun Och Yoon
Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC)...
June 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/28887760/sialadenoma-papilliferum-analysis-of-seven-new-cases-and-review-of-the-literature
#13
Craig B Fowler, Douglas D Damm
Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location...
June 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/28551385/low-grade-intraductal-carcinoma-low-grade-cribriform-cystadenocarcinoma-with-tumor-associated-lymphoid-proliferation-of-parotid-gland
#14
Toshimitsu Nishijima, Hidetaka Yamamoto, Takafumi Nakano, Yui Hatanaka, Ken-Ichi Taguchi, Muneyuki Masuda, Yoshinao Oda
We report a rare case of low-grade intraductal carcinoma with tumor-associated lymphoid proliferation (TALP) in the parotid gland of a 75-year-old woman. Grossly, the tumor was solid and cystic. Histologically, the tumor consisted of a papillary-cystic, micropapillary, or focally cribriform proliferations of epithelial cells with low-grade cytological atypia. The interspaces between the epithelial components were filled with prominent lymphoid stroma and lymphoid follicles, superficially mimicking Warthin tumor...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28507867/low-grade-cribriform-cystadenocarcinoma-a-review-of-the-literature-and-case-report
#15
Nao Wakabayashi, Hiroki Umezawa, Noriko M Matsumoto, Yoko Endo, Zenya Naito, Rei Ogawa
Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare tumor of the salivary gland that most often arises from the parotid gland. A 51-year-old man developed a small mass on the right parotid gland 5 years ago. A preoperative magnetic resonance image showed abnormal intensity, an atypical characteristic for such a tumor; therefore, the diagnosis was difficult. Thus, a superficial parotidectomy was performed as a total excisional biopsy to remove the tumor. Histopathological analyses revealed that the tumor was composed of a single cyst comprising cells containing mucosal fluid, with proliferation of large cells...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28440555/striated-duct-adenoma-presenting-with-intra-tumoral-hematoma-and-papillary-thyroid-carcinoma-like-histology
#16
Yohei Ito, Kana Fujii, Takayuki Murase, Kosuke Saida, Yoshihide Okumura, Hisashi Takino, Ayako Masaki, Shintaro Beppu, Daisuke Kawakita, Kei Ijichi, Hiroshi Inagaki
Striated duct adenoma of the salivary gland is a rare benign tumor characterized by unilayered duct epithelium and striations of the tumor cell membranes. To the best of our knowledge, only six cases have been reported in the literature. Here we report an additional case, which was complicated by an intra-tumoral hematoma on clinical presentation and by papillary thyroid carcinoma-like histology on intra-operative frozen section diagnosis. An asymptomatic 78-year-old male presented with a two-year-history of a painless tumor of the left parotid...
June 2017: Pathology International
https://www.readbyqxmd.com/read/28408701/mucoepidermoid-parotid-gland-tumor-found-on-follow-up-radioiodine-scan-for-differentiated-papillary-thyroid-cancer
#17
Chinna Naik, Sandip Basu
This report presents a case of focal uptake in the right parotid gland found on a follow-up whole-body radioiodine scan 1 y after successful ablation of differentiated papillary thyroid carcinoma. After the parotid tumor had been excised, it was proven histopathologically to be a low-grade mucoepidermoid tumor. This case illustrates a 131 I focus that was false-positive for thyroid carcinoma. The short period between radioiodine treatment and development of this parotid tumor creates doubt about a causal relationship...
June 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28386459/pathogenesis-of-warthin-s-tumors
#18
REVIEW
Yevhen V Kuzenko, Anatoly M Romanuk, Olena Olegivna Dyachenko, Olena Hudymenko
INTRODUCTION: Warthin's tumor, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma, or adenolymphoma, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and lymph node-like stroma. It is named after the pathologist Aldred Scott Warthin, who described two cases in 1929. OBJECTIVE: The aim of this study is to analyze the pathogenesis of Warthin's tumor. METHODS: A total of 15 patients with Warthin's tumor were studied...
June 1, 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28251831/cytologic-findings-of-mammary-analogue-secretory-carcinoma-arising-in-the-thyroid
#19
Paula A Rodríguez-Urrego, Snjezana Dogan, Oscar Lin
Mammary analogue secretory carcinoma (MASC) of the salivary gland, first described by Skálová et al in 2010, is a tumor that morphologically and genetically resembles breast secretory carcinoma harboring ETV6-NTRK3 fusion gene. To date, only seven cases of primary thyroid MASC have been described. The overall findings are similar to those seen in the salivary gland counterpart including the ETV6-NTRK3 fusion gene. This is the second report describing the cytologic features of MASC at this primary location, which also showed a classical type papillary carcinoma component...
June 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28247232/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-nasopharynx
#20
Edward B Stelow, Bruce M Wenig
The current WHO classification system for tumors of the head and neck has made few changes from the previous edition with regards to tumors of the nasopharynx. The classification system is discussed here with particular attention to nasopharyngeal carcinoma, nasopharyngeal papillary adenocarcinoma, salivary gland anlage tumor, hairy polyp, juvenile angiofibroma, and other tumors.
March 2017: Head and Neck Pathology
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